144 results match your criteria Lymphomas of the Head and Neck NK-Cell


Extranodal NK/T-Cell Lymphoma, Nasal Type in Guatemala: An 86-Case Series Emphasizing Clinical Presentation and Microscopic Characteristics.

Head Neck Pathol 2019 Mar 21. Epub 2019 Mar 21.

Centro Clínico de Cabeza y Cuello, Guatemala City, Guatemala.

Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is a lymphoid malignancy that mainly affects the nasopharynx and is associated with the Epstein-Barr virus (EBV). Increased incidence is seen in some Latin American and Asian countries. In this study, we describe a case series of 86 Guatemalan patients with ENKTCL-NT from a single diagnostic head and neck center. Read More

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http://dx.doi.org/10.1007/s12105-019-01027-zDOI Listing
March 2019
1 Read

Extranodal NK/T cell lymphoma, nasal type, with retrobulbar extraconal phlegmon and naso-oral fistula.

BMJ Case Rep 2019 Mar 9;12(3). Epub 2019 Mar 9.

Department of Otolaryngology, Head and Neck Surgery, Barwon Health, Geelong, Victoria, Australia.

Extranodal natural killer (NK-)/T cell lymphoma, nasal type (ENKL), is a rare disease that often mimics rheumatological and infectious conditions and can therefore be difficult to diagnose. The authors present a case of a 55-year-old Vietnamese woman who was misdiagnosed with severe atrophic rhinitis and chronic sinus osteitis. Over a period of 8 months from initial referral, she underwent multiple biopsies and was treated with various antimicrobial regimens until the histopathological diagnosis of ENKL was finally made. Read More

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http://dx.doi.org/10.1136/bcr-2018-227160DOI Listing
March 2019
1 Read

[Effectiveness of P-Gemox chemotherapy combined with radiotherapy in newly diagnosed,stage ⅠE to ⅡE, extranodal nasal type natural killer/T-cell lymphoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;33(2):132-137

The First Clinical Medical College of Lanzhou University.

To investigate the efficacy and safety of pegaspargase, gemcitabine, and oxaliplatin(P-Gemox) chemotherapy combined with radiotherapy in the treatment of newly diagnosed, stage IE to IIE of Extranodal nasal type natural killer/T-cell lymphoma(ENKTL) patients. P-Gemox chemotherapy combined with radiotherapy was used to analyze its clinical value and the factors affecting the prognosis in the treatment of 43 newly diagnosed ENKTL patients. In addition, toxicity related to chemotherapy was assessed. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2019.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.02.010DOI Listing
February 2019
5 Reads

Prognostic indicators of survival in sinonasal extranodal natural killer/T-cell lymphoma.

Laryngoscope 2019 Feb 23. Epub 2019 Feb 23.

Department of Otorhinolaryngology-Head and Neck Surgery, Rush Sinus Program, Rush University Medical Center, Rush University Medical Center, Chicago, Illinois, U.S.A.

Objectives: Extranodal natural killer/T-cell lymphoma (ENKTL) is a highly aggressive tumor of the sinonasal tract associated with poor overall survival (OS). This study expands upon epidemiologic, prognostic, and treatment factors for OS and disease-specific survival (DSS), incorporating newly accessible chemotherapy data.

Methods: Retrospective population-based cohort study performed on cases of sinonasal ENKTL identified through the Surveillance, Epidemiology, and End Results database. Read More

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http://dx.doi.org/10.1002/lary.27886DOI Listing
February 2019
2 Reads

Extranodal NK/T-cell lymphoma in adolescents: imaging findings of a consecutive 7-year case series.

J Int Med Res 2019 Mar 6;47(3):1210-1220. Epub 2019 Feb 6.

1 Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Objectives: Extranodal NK/T-cell lymphoma is reportedly a rare but emerging type of lymphoma in adolescents. The present study was performed to specify its imaging characteristics.

Methods: Our hospital's picture archiving and communication systems were searched from January 2009 to December 2016. Read More

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http://dx.doi.org/10.1177/0300060518822406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421368PMC
March 2019
2 Reads

Cyclin-dependent kinase 1 and survivin as potential therapeutic targets against nasal natural killer/T-cell lymphoma.

Lab Invest 2019 Jan 21. Epub 2019 Jan 21.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.

Nasal natural killer/T-cell lymphoma (NNKTL) is closely associated with Epstein-Barr virus (EBV) and is characterized by poor prognosis, resulting from rapid progression of lesions in the affected organs. Recent data have shown that NNKTL is associated with the aberrant expression of cyclin-dependent kinase 1 (CDK1) and its downstream target survivin, but little is known about the functional roles of CDK1 and survivin in NNKTL. In the current study, we show that knockdown of the EBV-encoded oncoprotein latent membrane protein 1 (LMP1) induces downregulation of CDK1 and survivin in NNKTL cells. Read More

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http://dx.doi.org/10.1038/s41374-018-0182-9DOI Listing
January 2019
2 Reads
3.676 Impact Factor

A Survival Analysis of Pediatric Tonsillar Malignancies and Review of a Rare Case.

Int J Pediatr Otorhinolaryngol 2019 Mar 28;118:160-164. Epub 2018 Dec 28.

University of Central Florida College of Medicine, Orlando, FL, USA; Division of Otolaryngology, Nemours Children's Hospital, Orlando, FL, USA. Electronic address:

Objective: To examine the survival of pediatric tonsillar cancer patients and review a rare case of pediatric tonsillar cancer.

Methods: Pediatric patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of tonsillar malignancy using the ICD O-3 tonsil primary site codes of: C09.0, C09. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183064
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http://dx.doi.org/10.1016/j.ijporl.2018.12.033DOI Listing
March 2019
4 Reads

Acute Epstein-Barr virus-positive cytotoxic T cell lymphoid hyperplasia in the upper aerodigestive tract, mimicking extranodal natural killer/T cell lymphoma, nasal type.

Virchows Arch 2019 Feb 28;474(2):219-226. Epub 2018 Nov 28.

Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.

To describe the clinicopathological features of nine patients with acute Epstein-Barr virus (EBV)-positive cytotoxic T cell lymphoid hyperplasia (EBV+TLH) in the upper aerodigestive tract, in which initial findings led to a preliminary misdiagnosis of extranodal NK/T cell lymphoma, nasal type (ENKTL). A series of nine cases of EBV+TLH in one Chinese institution over a 9-year interval was retrospectively analyzed. Median age was 16 years (range 5-29 years) with a M:F ratio of 5:4. Read More

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http://dx.doi.org/10.1007/s00428-018-2498-7DOI Listing
February 2019
2 Reads

Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer.

Oncoimmunology 2018 1;7(9):e1471440. Epub 2018 Aug 1.

National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

Head and neck squamous cell carcinomas (HNSCCs) frequently harbor genomic mutations in cell death pathways. Nearly 30% of HNSCCs overexpress Fas-Associated Death Domain (FADD), with or without BIRC2/3 genes encoding cellular Inhibitor of Apoptosis Proteins 1/2 (cIAP1/2), critical components of the Tumor Necrosis Factor (TNF) Receptor signaling pathways. ASTX660 is a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP under evaluation in a clinical trial for advanced solid tumors and lymphomas. Read More

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1
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http://dx.doi.org/10.1080/2162402X.2018.1471440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209421PMC
August 2018
8 Reads

Extranodal lymphomas in the public health system in Chile: Analysis of 1251 patients from the National Adult Cancer Program.

Hematol Oncol 2019 Feb 14;37(1):47-53. Epub 2018 Sep 14.

Medicine Service, Hematology Section, Hospital del Salvador, University of Chile, Santiago, Chile.

The aim of the study was to describe the clinical and epidemiological characteristics, anatomic and histologic distribution, and treatment results of extranodal lymphomas (ENLs), diagnosed and treated in the public health system in Chile. We included patients with ENL diagnosed from 1998 to 2014, in 17 cancer centers, registered prospectively in the database of the National Adult Cancer Program (PANDA) of the Ministry of Health. Treatment was based on the local protocols for each lymphoma subtype. Read More

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http://doi.wiley.com/10.1002/hon.2547
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http://dx.doi.org/10.1002/hon.2547DOI Listing
February 2019
14 Reads

Lymphoma associated hemophagocytic syndrome: A single-center retrospective study.

Oncol Lett 2018 Jul 22;16(1):1275-1284. Epub 2018 May 22.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

To improve the understanding of lymphoma associated hemophagocytic syndrome (LAHS) and find an effective treatment for this fatal disease, 57 patients with LAHS were retrospectively reviewed. The most common histopathological type was extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKL) (45.61%). Read More

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http://dx.doi.org/10.3892/ol.2018.8783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063042PMC
July 2018
8 Reads
0.990 Impact Factor

[Laryngeal NK/T cell lymphoma mainly manifested as sore throat, hoarseness, fever: a case report].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jun;53(6):448-449

Department of Otorhinolaryngology Head and Neck Surgery, the Third Hospital of Peking University, Beijing100191, China.

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2018.06.012DOI Listing

Clinical manifestation of malignant lymphomas of the head and neck region.

Otolaryngol Pol 2017 Dec;71(6):14-21

Department of Otorhinolaryngology, Medical University of Lodz, Poland.

Introduction: Malignant lymphoma (ML) is a neoplasm caused by clonal expansion of undifferentiated B, T and NK-lymphoid cells. WHO classification divides lymphomas into two main types, i.e. Read More

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http://dx.doi.org/10.5604/01.3001.0010.7192DOI Listing
December 2017
6 Reads

Systemic Non-Hodgkin T Cell Lymphomas Presenting in the Head and Neck Region: An Institutional Experience of a Rare Entity.

Head Neck Pathol 2018 Dec 4;12(4):481-487. Epub 2018 Jan 4.

Department of Pathology, University of Alabama at Birmingham, 1802 6th Ave S, NP 3545, Birmingham, AL, 35233-7331, USA.

T cell lymphoma (TCL) is a group of rare and aggressive diseases. TCL primary to head and neck organs often present as extranodal NK/T cell lymphoma, nasal type. Systemic TCL with initial head and neck presentation is extremely rare. Read More

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http://link.springer.com/10.1007/s12105-017-0881-3
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http://dx.doi.org/10.1007/s12105-017-0881-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232224PMC
December 2018
4 Reads

Copanlisib: First Global Approval.

Authors:
Anthony Markham

Drugs 2017 Dec;77(18):2057-2062

Springer, Private Bag 65901, Mairangi Bay, 0754, Auckland, New Zealand.

Bayer are developing copanlisib (Aliqopa™)-a pan-class I phosphoinositide 3-kinase (PI3K) inhibitor-as a treatment for various haematological and solid malignancies. The US FDA has granted copanlisib accelerated approval for the treatment of adults with relapsed follicular lymphoma who have received at least two prior systemic therapies based on the results of a phase II trial. Phase III trials are underway evaluating copanlisib as treatment for relapsed/refractory diffuse large B-cell lymphoma and in combination with rituximab or rituximab-based chemotherapy or standard immunochemotherapy in patients with relapsed indolent B-cell non-Hodgkin's lymphoma. Read More

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http://dx.doi.org/10.1007/s40265-017-0838-6DOI Listing
December 2017
5 Reads

Autologous hematopoietic stem cell transplantation may improve long-term outcomes in patients with newly diagnosed extranodal natural killer/T-cell lymphoma, nasal type: a retrospective controlled study in a single center.

Int J Hematol 2018 Jan 30;107(1):98-104. Epub 2017 Aug 30.

Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Dong Jiao Min Xiang Street, No.1, Dong Cheng District, Beijing, 10073, China.

Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a rare disease with a poor prognosis. The long-term effect of autologous hematopoietic stem cell transplantation (auto-HSCT) on ENKTL has been reported occasionally but needs further investigation. In this retrospective study from a single center, 20 ENKTL patients who received induction chemotherapy followed by auto-HSCT ± involved-field radiotherapy (IFRT) ± additional chemotherapy were enrolled as a study group. Read More

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http://dx.doi.org/10.1007/s12185-017-2324-zDOI Listing
January 2018
10 Reads

Successful treatment with anti-programmed-death-1 antibody in a relapsed natural killer/T-cell lymphoma patient with multi-line resistance: a case report.

BMC Cancer 2017 Jul 28;17(1):507. Epub 2017 Jul 28.

Department of oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.

Background: Extranodal natural killer/T-cell lymphoma (NKTCL), nasal type, is an aggressive malignancy with poor prognosis. Currently, there is no recommended standard therapy for relapsed NKTCL.

Case Presentation: A 37-year-old woman with lymphadenopathy was diagnosed with NKTCL by biopsy of an enlarged lymph node on the right side of her neck. Read More

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http://dx.doi.org/10.1186/s12885-017-3501-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534108PMC
July 2017
23 Reads

Deceptive nasal NK/T-cell lymphoma.

Trop Doct 2017 Jul 20;47(3):268-271. Epub 2016 Dec 20.

3 Professor, Department of Otolaryngology-Head and Neck Surgery (ENT), Indira Gandhi Medical College, Shimla, HP, India.

Nasal NK/T cell lymphoma is rare and it easily masquerades as chronic rhinosinusitis. It has a very poor prognosis and hence early diagnosis, although difficult, is necessary for better outcome. We present a case of a 30-year-old man who presented with nasal obstruction, facial oedema and crusts. Read More

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http://dx.doi.org/10.1177/0049475516684088DOI Listing
July 2017
9 Reads

Usefulness of NKX2.2 Immunohistochemistry for Distinguishing Ewing Sarcoma from Other Sinonasal Small Round Blue Cell Tumors.

Head Neck Pathol 2018 Mar 14;12(1):89-94. Epub 2017 Jun 14.

Department of Pathology, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Pathology Building, Room 401, Baltimore, MD, 21287, USA.

NKX2.2 is a new immunohistochemical marker that has been reported to be sensitive and specific for Ewing sarcoma (ES). It has not, however, been investigated specifically in the sinonasal small round blue cell tumor (SRBCT) differential diagnosis which includes many tumors specific to that site. Read More

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http://dx.doi.org/10.1007/s12105-017-0830-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873485PMC
March 2018
10 Reads

Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy.

Cancer Immunol Immunother 2017 Jul 27;66(7):877-890. Epub 2017 Mar 27.

Department of Pathology, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, 078-8510, Japan.

Nasal natural killer/T-cell lymphoma (NNKTL) is an aggressive neoplasm with poor therapeutic responses and prognosis. The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) pathway plays an important role in immune evasion of tumor cells through T-cell exhaustion. The aim of the present study was to examine the expression of PD-L1 and PD-1 molecules in NNKTL. Read More

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http://dx.doi.org/10.1007/s00262-017-1987-xDOI Listing
July 2017
19 Reads

Epidemiology of Nasopharyngeal Lymphoma in the United States: A Population-Based Analysis of 1119 Cases.

Otolaryngol Head Neck Surg 2017 05 21;156(5):870-876. Epub 2017 Mar 21.

1 Department of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California, USA.

Objectives To describe the incidence and determinants of survival of patients with nasopharyngeal lymphoma (NPL) between 1973 and 2012 using the Surveillance, Epidemiology, and End Results (SEER) database. Study Design Retrospective cohort study using a national database. Methods The SEER registry was used to calculate survival trends for patients with NPL between 1973 and 2012. Read More

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http://dx.doi.org/10.1177/0194599817695808DOI Listing
May 2017
16 Reads

[Extranodal NK/T-cell lymphoma, nasal type: a clinical analysis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Mar;31(5):327-333

Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.

To explore the clinical diagnosis and treatment characteristics and clinical factors of extranodal NK/T-cell lymphoma, nasal type and provide the basis for clinical individual therapy and experience.The 25 cases personal data of ENKTL received from December in 2009 to July in 2016 by our department including clinical manifestation, the serum EBV-DNA detection, imaging examination, Ann-Arbor staging, histological grade, treatment, and prognosis, etc. were retrospectively analyzed. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2017.05.001DOI Listing

Nasal Type Extranodal Natural Killer/T (NK/T) Cell Lymphoma Presenting as Periorbital Cellulitis: A Case Report.

Am J Case Rep 2016 Dec 9;17:934-938. Epub 2016 Dec 9.

Department of Otolaryngology, Hamad Medical Corporation, Doha, Qatar.

BACKGROUND Extranodal lymphoma of the paranasal sinuses is a rare clinical entity seen in only 5-8% of extranodal lymphomas of the head and neck. Nasal natural killer/T cell lymphoma (Nasal NKTCL), which is a subtype of peripheral T cell lymphoma, constitutes about 1.4% of all lymphomas. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153321PMC
December 2016
8 Reads

Characterizing CD137 upregulation on NK cells in patients receiving monoclonal antibody therapy.

Ann Oncol 2017 02;28(2):415-420

Department of Medicine, Division of Oncology, Stanford University , Stanford, CA, USA.

Background: In the era of personalized cancer medicine, identifying techniques for effectively matching patients to efficacious treatments is a critical step in the treatment process. The advent of anti-cancer immunotherapies necessitates novel approaches to biomarker identification beyond traditional genomic profiling. One promising approach is incorporation of nomograms into treatment decisions. Read More

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http://dx.doi.org/10.1093/annonc/mdw570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246233PMC
February 2017
3 Reads

Circulating Epstein-Barr virus-encoded micro-RNAs as potential biomarkers for nasal natural killer/T-cell lymphoma.

Hematol Oncol 2017 Dec 6;35(4):655-663. Epub 2016 Oct 6.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.

Nasal natural killer/T-cell lymphoma (NNKTL) is an Epstein-Barr virus (EBV)-associated malignancy and is characterized by local invasion and widespread dissemination, with a consequent poor prognosis. Micro-RNAs (miRNAs) play roles in the pathogenesis of several malignancies by regulating gene expression and have been recently identified as stable entities in serum. Here, we investigated the value of circulating EBV-miRNAs as biomarkers for NNKTL. Read More

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http://dx.doi.org/10.1002/hon.2360DOI Listing
December 2017
17 Reads

A 14-year-old boy with extranodal natural killer cell lymphoma of the nose, nasopharynx, larynx, and trachea in remission 6years after primary diagnosis. A longitudinal case report.

Am J Otolaryngol 2016 Nov - Dec;37(6):563-566. Epub 2016 Aug 12.

Department of Pediatric Hematology and Oncology, LSUHSC-Shreveport, Shreveport, LA, United States.

Nasal type extranodal natural killer/T-cell lymphoma (ENKTL) is a rare lymphoma in the USA and Europe but endemic in East Asia and in areas of South and Central America. Clinically natural killer cell lymphomas are divided into three categories; nasal, non-nasal and aggressive lymphoma/leukemia subtypes. ENKTL, nasal type occurs in the nose and can extend to the upper aero-digestive tract as reported in this longitudinal case study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960709163022
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http://dx.doi.org/10.1016/j.amjoto.2016.08.004DOI Listing
September 2017
8 Reads

[Role of radiotherapy in the treatment of NK/T-cell nasal type and primary cerebral lymphomas].

Cancer Radiother 2016 Oct 7;20(6-7):535-42. Epub 2016 Sep 7.

Département d'oncologie radiothérapie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France; Université Paris Saclay, 15, rue Georges-Clemenceau, 91400 Orsay, France. Electronic address:

The head and neck are common sites for extranodal non-Hodgkin lymphomas. Radiotherapy plays an important role in the treatment of low-grade lymphomas, with curative or palliative intent. In the case of high-grade lymphomas, its combination with chemotherapy is debated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12783218163035
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http://dx.doi.org/10.1016/j.canrad.2016.07.078DOI Listing
October 2016
3 Reads

Delayed diagnosis of sinonasal lymphoma due to bilateral manifestation.

Eur Arch Otorhinolaryngol 2017 Feb 31;274(2):823-827. Epub 2016 Aug 31.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich and University of Zurich, Frauenklinikstr. 24, 8091, Zurich, Switzerland.

The objective of this study is to analyze the presenting symptoms, the time to correct diagnosis and outcome of a European patient cohort with sinonasal lymphoma focusing on unilateral vs. bilateral sinonasal involvement. In a retrospective setting in a European tertiary referral center, eleven patients (9 males, 2 females) with sinonasal lymphoma diagnosed between 2002 and 2015 were identified and divided into a unilateral and bilateral group according to their CT finding. Read More

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http://link.springer.com/10.1007/s00405-016-4275-z
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http://dx.doi.org/10.1007/s00405-016-4275-zDOI Listing
February 2017
8 Reads

A combinational therapy of EGFR-CAR NK cells and oncolytic herpes simplex virus 1 for breast cancer brain metastases.

Oncotarget 2016 May;7(19):27764-77

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

Breast cancer brain metastases (BCBMs) are common in patients with metastatic breast cancer and indicate a poor prognosis. These tumors are especially resistant to currently available treatments due to multiple factors. However, the combination of chimeric antigen receptor (CAR)-modified immune cells and oncolytic herpes simplex virus (oHSV) has not yet been explored in this context. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053686PMC
http://dx.doi.org/10.18632/oncotarget.8526DOI Listing
May 2016
31 Reads

Chemoradiotherapy for localized extranodal natural killer/T-cell lymphoma, nasal type, using a shrinking-field radiation strategy: multi-institutional experience.

Jpn J Radiol 2016 Apr 6;34(4):292-9. Epub 2016 Feb 6.

Department of Radiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.

Purposes: The prognosis of localized extranodal natural killer/T-cell lymphoma, nasal type (ENKTL), has improved with the development of chemoradiotherapy. However, conventional extended-field radiotherapy may cause optic disorders. Our group has employed smaller radiation fields in an attempt to avoid toxicity. Read More

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http://dx.doi.org/10.1007/s11604-016-0524-8DOI Listing
April 2016
18 Reads

[Extranodal natural killer/T-cell lymphoma, nasal type developing central nervous system and epididymis involvement immediately after concurrent chemoradiotherapy].

Rinsho Ketsueki 2015 Dec;56(12):2472-6

Department of Hematology, Kokura Memorial Hospital.

A 66-year-old man showed central nervous system (CNS) and epididymis involvement after concurrent chemoradiotherapy for extranodal natural killer/T-cell lymphoma, nasal type (ENKL). The patient experienced continuous nasal obstruction. CT revealed a mass in the nasal cavity and paranasal sinuses. Read More

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http://dx.doi.org/10.11406/rinketsu.56.2472DOI Listing
December 2015
12 Reads

Novel treatment for early-stage nasal natural killer/T-cell lymphoma: intra-maxillary arterial infusion chemotherapy with concomitant radiotherapy.

Hematol Oncol 2017 Jun 13;35(2):158-162. Epub 2015 Nov 13.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, 078-8510, Japan.

Nasal natural killer (NK)/T-cell lymphoma (NNKTL) displays unusual clinicopathological features, and the prognosis is very poor, even in the early stages of the disease. For early stage NNKTL, we have developed a novel chemoradiotherapy regimen incorporating arterial infusion chemotherapy, administered via the superficial temporal artery, in combination with radiotherapy. The novel arterial infusion regimen consists of ifosfamide, carboplatin, methotrexate, peplomycin, and etoposide (MPVIC-P). Read More

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http://dx.doi.org/10.1002/hon.2273DOI Listing
June 2017
15 Reads

A comparison of volumetric modulated arc therapy and sliding-window intensity-modulated radiotherapy in the treatment of Stage I-II nasal natural killer/T-cell lymphoma.

Med Dosim 2016 1;41(1):42-6. Epub 2015 Oct 1.

Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, PR China. Electronic address:

This article is aimed to compare the dosimetric differences between volumetric modulated arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) for Stage I-II nasal natural killer/T-cell lymphoma (NNKTL). Ten patients with Stage I-II NNKTL treated with IMRT were replanned with VMAT (2 arcs). The prescribed dose of the planning target volume (PTV) was 50Gy in 25 fractions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09583947150010
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http://dx.doi.org/10.1016/j.meddos.2015.07.003DOI Listing
December 2016
10 Reads

A TNM Staging System for Nasal NK/T-Cell Lymphoma.

PLoS One 2015 22;10(6):e0130984. Epub 2015 Jun 22.

Stage Key Laboratory of Oncology in South China, Guangzhou, Guangdong, China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China; Medical Imaging Department, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.

Ann Arbor stage has limited utility in the prognostication and treatment decision making in patients with NK/T-cell lymphoma (NKTCL), as NKTCL is almost exclusively extranodal and the majority is localized at presentation for which radiotherapy is the most important treatment and local invasiveness is the most important prognostic factor. In this study, we attempted to establish a TNM (Tumor-Node-Metastasis) staging system for nasal NKTCL (N-NKTCL). The staging rules of other head and neck cancers were used as reference along with the data of our 271 eligible patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130984PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476596PMC
March 2016
31 Reads

Nasal endoscopic evaluation and its impact on survival in patients with stage I/II extranodal natural killer/T-cell lymphoma, nasal type.

Int Forum Allergy Rhinol 2015 Oct 3;5(10):960-6. Epub 2015 Jun 3.

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Endoscopic findings of extranodal natural killer/T-cell lymphoma (ENKTL), nasal type, are heterogeneous, but not fully understood. The objective of this study was to evaluate the role of nasal endoscopic examination and its implications for treatment of stage I/II ENKTL.

Methods: This retrospective study included 60 consecutive patients diagnosed with stage I/II ENKTL, nasal type, from 2000 to 2011. Read More

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http://dx.doi.org/10.1002/alr.21564DOI Listing
October 2015
15 Reads

Long-term Outcome of Extranodal NK/T Cell Lymphoma Patients Treated With Postremission Therapy Using EBV LMP1 and LMP2a-specific CTLs.

Mol Ther 2015 Aug 28;23(8):1401-1409. Epub 2015 May 28.

Department of Microbiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address:

Extranodal NK/T-cell lymphoma (ENKTCL) is associated with latent Epstein-Barr virus (EBV) infection and frequent relapse even after complete response (CR) to intensive chemotherapy and radiotherapy. The expression of EBV proteins in the tumor provides targets for adoptive immunotherapy with antigen-specific cytotoxic T cells (CTL). To evaluate the efficacy and safety of EBV latent membrane protein (LMP)-1 and LMP-2a-specific CTLs (LMP1/2a CTLs) stimulated with LMP1/2a RNA-transferred dendritic cells, we treated 10 ENKTCL patients who showed complete response to induction therapy. Read More

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http://dx.doi.org/10.1038/mt.2015.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817864PMC
August 2015
44 Reads

c-Met is a novel tumor associated antigen for T-cell based immunotherapy against NK/T cell lymphoma.

Oncoimmunology 2015 Feb 6;4(2):e976077. Epub 2015 Mar 6.

Department of Pathology; Asahikawa Medical University ; Asahikawa, Japan.

The expression of c-Met and its ligand HGF plays a critical role in cell proliferation and is involved in numerous malignancies. Because c-Met expression and its role in NK/T-cell lymphoma remain unclear, we studied the expression and function of c-Met in NK/T-cell lymphoma cells. In addition, we investigated the possibility that c-Met could function as a tumor-associated antigen for helper T lymphocytes (HTLs). Read More

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http://dx.doi.org/10.4161/2162402X.2014.976077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404796PMC
February 2015
7 Reads

CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma.

Cancer Immunol Immunother 2015 Jun 10;64(6):697-705. Epub 2015 Mar 10.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, 078-8510, Japan.

Nasal natural killer/T-cell lymphoma (NNKTL) is associated with Epstein-Barr virus and has a poor prognosis because of local invasion and/or multiple dissemination. Various chemokines play a role in tumor proliferation and invasion, and chemokine receptors including the C-C chemokine receptor 4 (CCR4) are recognized as potential targets for treating hematologic malignancies. The aim of the present study was to determine whether specific chemokines are produced by NNKTL. Read More

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http://link.springer.com/10.1007/s00262-015-1675-7
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http://dx.doi.org/10.1007/s00262-015-1675-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648286PMC
June 2015
25 Reads

Nasal type natural killer T-cell lymphoma involving nasooropharynx and larynx.

Kulak Burun Bogaz Ihtis Derg 2014 Nov-Dec;24(6):364-7

Department of Otolaryngology, Medical Faculty of Abant İzzet Baysal University, 14280 Gölköy, Bolu, Turkey.

Lymphoma is one of the malignant non-squamous tumors involving the head and neck. Lymphomas in this region are mostly B-cell type in origin and usually seen in Waldeyer's ring. In this article, we report a 45-year-old female case of primary natural killer T cell lymphoma-nasal type involving the nasooropharynx and larynx. Read More

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http://dx.doi.org/10.5606/kbbihtisas.2014.86619DOI Listing
October 2015
6 Reads

A comparative population-based analysis of sinonasal diffuse large B-cell and extranodal NK/T-cell lymphomas.

Laryngoscope 2015 May 27;125(5):1077-83. Epub 2014 Dec 27.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, U.S.A.

Objective/hypothesis: Diffuse large B-cell lymphoma (DLBCL) and extranodal natural killer/T-cell lymphoma (ENKTL) are aggressive tumors. ENTKL is very rare in the United States and often affects the nasal cavity and paranasal sinuses; DLBCL, although more common, rarely occurs in these locations. Our study aims to compare incidence and survival of these lymphomas in the sinonasal cavity. Read More

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http://dx.doi.org/10.1002/lary.25111DOI Listing
May 2015
24 Reads
3 Citations
2.032 Impact Factor

An unusual presentation of NK/T-cell lymphoma, nasal-type in the United States.

Am J Otolaryngol 2015 Jan-Feb;36(1):80-3. Epub 2014 Jul 24.

Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Introduction: NK/T-cell lymphoma (NKCL), nasal-type is rare in the United States, representing only 1.5% of non-Hodgkin lymphomas. Classically, patients initially present with nasal obstruction (70%), caused by invasion of the localized lesion into the sinuses and nasal cavities. Read More

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http://dx.doi.org/10.1016/j.amjoto.2014.07.012DOI Listing
August 2015
29 Reads

Clinical characteristics, pathological distribution, and prognostic factors in non-Hodgkin lymphoma of Waldeyer's ring: nationwide Korean study.

Korean J Intern Med 2014 May 29;29(3):352-60. Epub 2014 Apr 29.

Division of Hematology-Oncology, Department of Internal Medicine, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

Background/aims: In Asia, the incidence of non-Hodgkin lymphoma (NHL) has increased in recent decades. Waldeyer's ring (WR) is the most common site of NHL involving the head and neck. In this study, the pathological distribution of WR-NHL and its clinical features were analyzed retrospectively. Read More

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http://dx.doi.org/10.3904/kjim.2014.29.3.352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028525PMC
May 2014
22 Reads

Nasal T cell lymphoma: a rare entity.

J Coll Physicians Surg Pak 2014 Mar;24 Suppl 1:S50-1

Department of ENT- Head and Neck Surgery, Jinnah Medical and Dental College, Karachi.

Nasal type of Natural Killer (NK)/T cell lymphoma manifests in the nasal cavity. Approximately 95% of them are associated with EBV(Ebstein Barr Virus) with a strong predilection for the Asian population. It has certain systemic and localized symptoms which aid in diagnosis of the condition. Read More

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http://dx.doi.org/03.2014/JCPSP.S50S51DOI Listing
March 2014
3 Reads

Orbital and central nervous system extension of nasal natural killer/T-cell lymphoma.

Ophthalmic Plast Reconstr Surg 2014 Jan-Feb;30(1):20-3

*School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil; †King Khaled Eye Specialist Hospital, Johns Hopkins University; ‡Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, §Department of Pathology, and ‖Department of Radiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.

Background: To describe a case series of nasal natural killer (NK)/T-cell lymphoma (NKTL) with orbital and central nervous system extension.

Methods: This is a retrospective study. The medical records of 9 patients with a diagnosis of NKTL were reviewed. Read More

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http://dx.doi.org/10.1097/IOP.0b013e3182a7500eDOI Listing
June 2014
2 Reads

Extranodal natural killer/T-Cell lymphoma: A population-based comparison of sinonasal and extranasal disease.

Laryngoscope 2014 Apr 7;124(4):888-95. Epub 2013 Oct 7.

Department of Otolaryngology-Head and Neck Surgery, Newark, New Jersey, U.S.A.

Objectives/hypothesis: Extranodal natural killer/T-cell Lymphoma (ENKTL) is a rare, aggressive malignancy that preferentially affects the paranasal region. This study analyzes the demographic, clinicopathologic, incidence, and survival characteristics of sinonasal ENKTL (SN-ENKTL) and extranasal ENKTL (EN-ENKTL) in a comparative fashion.

Study Design: Retrospective analysis. Read More

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http://dx.doi.org/10.1002/lary.24371DOI Listing
April 2014
4 Reads

Increased expression of Trop2 correlates with poor survival in extranodal NK/T cell lymphoma, nasal type.

Virchows Arch 2013 Nov 25;463(5):713-9. Epub 2013 Aug 25.

Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Nanjing Medical University, No.121 Jiang jia yuan, Nanjing, 210011, China.

Human trophoblastic cell surface antigen 2 (Trop2) has been suggested to play an important role in the development of solid tumors. However, the expression of Trop2 in extranodal NK/T cell lymphoma, nasal type (ENKTL) and the relationship with the clinical characteristics of this disease remain poorly understood. In this study, one-step quantitative PCR reverse transcription-polymerase chain reaction and immunohistochemical staining with tissue sections were employed to evaluate the expression of Trop2 in ENKTL. Read More

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http://link.springer.com/content/pdf/10.1007/s00428-013-1475
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http://link.springer.com/10.1007/s00428-013-1475-4
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http://dx.doi.org/10.1007/s00428-013-1475-4DOI Listing
November 2013
6 Reads

Downregulation of miR-15a due to LMP1 promotes cell proliferation and predicts poor prognosis in nasal NK/T-cell lymphoma.

Am J Hematol 2014 Jan 30;89(1):25-33. Epub 2013 Sep 30.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Midorigaoka-higashi 2-1-1-1, Asahikawa, Japan.

Nasal NK/T-cell lymphoma (NNKTL) is an Epstein-Barr virus (EBV)-associated malignancy and has distinct clinical and histological features. However, its genetic features are hitherto unclear. MicroRNAs (miRNAs) play a crucial role in the pathogenesis of several malignancies via regulating gene expression. Read More

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http://dx.doi.org/10.1002/ajh.23570DOI Listing
January 2014
11 Reads

Novel and simple prognostic index for nasal natural killer/T-cell lymphoma.

Head Neck 2014 Apr 18;36(4):551-6. Epub 2013 Jun 18.

Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background: Few studies have investigated the prognostic factors for nasal natural killer (NK)/T-cell lymphoma.

Methods: This was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T-cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals. Read More

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http://dx.doi.org/10.1002/hed.23322DOI Listing
April 2014
19 Reads

Radiation recall reaction: two case studies illustrating an uncommon phenomenon secondary to anti-cancer agents.

Cancer Biol Med 2012 Sep;9(3):202-4

Department of Radiation Oncology, Xiangya Medical College Affiliated Cancer Hospital of Hu'nan Province, Zhongnan University, Changshan 410013, China.

Radiation recall phenomenon is a tissue reaction that develops throughout a previously irradiated area, precipitated by the administration of certain drugs. Radiation recall is uncommon and easily neglected by physicians; hence, this phenomenon is underreported in literature. This manuscript reports two cases of radiation recall. Read More

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http://dx.doi.org/10.7497/j.issn.2095-3941.2012.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643667PMC
September 2012
28 Reads

Extranodal lymphomas of head and neck with emphasis on NK/T-cell lymphoma, nasal type.

J Craniomaxillofac Surg 2014 Mar 18;42(2):149-52. Epub 2013 May 18.

Department of Ophthalmology (Head: Janjetovic Zeljka, MD), General Hospital "Dr. Josip Bencevic", Slavonski Brod, Croatia.

Purpose: To determine the occurrence, clinical course and outcome of our patients with natural killer/T-cell lymphoma (NKTCL), nasal type. The nasal type of natural killer/T-cell lymphoma (NKTCL), is rare in the European population but is more frequent in Asia, Central and South America where it accounts for 15-20% of all non-Hodgkin lymphomas (NHL). This type of lymphoma is characterized by tissue necrosis and destruction of the nasal cavity and upper aero-digestive tract. Read More

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http://dx.doi.org/10.1016/j.jcms.2013.04.004DOI Listing
March 2014
14 Reads