3,633 results match your criteria Lymphomas of the Head and Neck


Prognostic significance of locally invaded sites and tissue types in patients with nasal extranodal natural-killer/T-cell lymphoma: a single-center, retrospective analysis.

Chin Med J (Engl) 2019 Jan 10. Epub 2019 Jan 10.

Key Laboratory of Head and Neck Molecular Pathological Diagnosis, Capital Medical University, Beijing 100730, China.

Background: Extranodal natural-killer/T-cell lymphoma (ENKTL), nasal-type, is an aggressive entity within the World Health Organization (WHO) classification of lymphoid tumors. The International Prognostic Index (IPI) is reported to be prognostically meaningful for ENKTL, but lacks discriminatory power for stage I/II ENKTL with extensive local invasion. This study aimed to evaluate the prognostic effects of local invasion by site and tissue type in patients with ENKTL. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000263DOI Listing
January 2019

Cisplatin: The first metal based anticancer drug.

Authors:
Sumit Ghosh

Bioorg Chem 2019 Apr 11;88:102925. Epub 2019 Apr 11.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India. Electronic address:

Cisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways which finally lead to apoptosis. However, side effects and drug resistance are the two inherent challenges of cisplatin which limit its application and effectiveness. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.102925DOI Listing
April 2019
2 Reads

Investigation of lymphoid lesions of the Head and Neck using combined fine needle aspiration cytology and flow cytometry: accuracy and pitfalls.

Cytopathology 2019 Apr 15. Epub 2019 Apr 15.

Cytology Department, Sullivan Nicolaides Pathology, 24 Hurworth St, Bowen Hills, 4006.

Objective: We reviewed the diagnostic utility of combined fine needle aspiration cytology (FNAC) and flow cytometry (FC) in the diagnosis of lymphoid lesions of the head and neck.

Method: 1402 patients with combined FNAC-FC reports were correlated with follow-up information. Rapid on-site evaluation (ROSE) of cytological specimens was performed in 52% of cases. Read More

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http://dx.doi.org/10.1111/cyt.12706DOI Listing
April 2019
2 Reads

[Clinical features of mucosa-associated lymphoid tissue lymphoma in head and neck].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):362-366

To summarize the clinical features, diagnosis and treatment of mucosa-associated lymphoid tissue(MALT) lymphoma in head and neck. The clinical data of 22 hospitalizedpatients with MALT lymphoma in head and neck during the recent 18 years were analyzed retrospectively. Among the 22 cases, 13 patients showed salivary gland lesions, 4 showed larynx and trachea lesions,3 showed nasopharynx lesions and 2 showed thyroid gland lesions. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.018DOI Listing
April 2019
7 Reads

[Application of nuclear magnetic dispersion weighted imaging and apparent diffusion coefficient in the identification of benign].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):342-346

Department of Head and Neck Surgery, Shanxi Province Tumor Hospital,Taiyuan,030013,China.

To determine the diagnostic role of diffusionweighted imaging(DWI) and apparent diffusion coefficient(ADC) under different b values in differentiating benign and malignant thyroid nodules by using postoperative histopathological results were taken as the reference standard. From January 2017 to June 2018, 64 patients with thyroid nodules diagnosed by ultrasound in the head and neck surgery of Shanxi Cancer Hospital were collected, and a total of 80 nodules were collected. The Philips 3. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.013DOI Listing
April 2019
1 Read

Evaluation of a case of diffuse large B-cell lymphoma.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):7-11

Department of Oral and Maxillofacial Pathology and Microbiology, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.

Lymphomas are a group of malignant blood cell tumors that develop from lymphocytes representing 2.2% of all malignant neoplasms of the head and neck. Two main categories of lymphomas are Hodgkin's lymphoma and non-Hodgkin's lymphoma (NHL) of which 90% are of the NHL type. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_100_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421931PMC
February 2019
4 Reads

Loss of exosomal miR-3188 in cancer-associated fibroblasts contributes to HNC progression.

J Exp Clin Cancer Res 2019 Apr 8;38(1):151. Epub 2019 Apr 8.

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China.

Background: Head and neck cancer (HNC) is one of the most common deadly diseases worldwide. An increasing number of studies have recently focused on the malignant functions of cancer-associated fibroblasts (CAFs) in numerous cancers. However, the underlying mechanisms by which CAF-derived exosomes promote tumor progression need to be further elucidated. Read More

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http://dx.doi.org/10.1186/s13046-019-1144-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454737PMC
April 2019
1 Read

Identification of rare variants predisposing to thyroid cancer.

Thyroid 2019 Apr 8. Epub 2019 Apr 8.

The Ohio State University, Human Cancer Genetics Program , 460 W.12th Ave , Columbus, Ohio, United States , 432310 ;

Background: Familial non-medullary thyroid cancer (FNMTC) accounts for a relatively small proportion of thyroid cancer cases, but it displays strong genetic predisposition. So far, only a few of NMTC susceptible genes and low-penetrance variants contributing to NMTC have been described. In this study, we aim to identify rare germline variants that may predispose individuals to non-medullary thyroid carcinoma (NMTC) by sequencing a cohort of 17 NMTC families. Read More

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http://dx.doi.org/10.1089/thy.2018.0736DOI Listing
April 2019
2 Reads
4.493 Impact Factor

Enhancing value of quality assurance rounds in improving radiotherapy management: a retrospective analysis from King Hussein Cancer Center in Jordan.

Radiat Oncol J 2019 Mar 31;37(1):60-65. Epub 2019 Mar 31.

Department of Radiation Oncology, King Hussein Cancer Center, Amman, Jordan.

Purpose: The quality assurance (QA) chart rounds are multidisciplinary meetings to review radiation therapy (RT) treatment plans. This study focus on describing the changes in RT management based on QA round reviews in a single institution.

Materials And Methods: After 9 full years of implementation, a retrospective review of all patients whose charts passed through departmental QA chart rounds from 2007 to 2015. Read More

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http://e-roj.org/journal/view.php?doi=10.3857/roj.2019.00080
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http://dx.doi.org/10.3857/roj.2019.00080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453807PMC
March 2019
5 Reads

Sox11 promotes head and neck cancer progression via the regulation of SDCCAG8.

J Exp Clin Cancer Res 2019 Mar 29;38(1):138. Epub 2019 Mar 29.

School of Dentistry, University of California, Los Angeles, CA, 90095, USA.

Background: SOX11 is a transcription factor that plays an important role in mantle cell lymphoma development. However, its functional role in head and neck squamous cell carcinoma (HNSCC) remains unknown.

Methods: Protein expression was measured with Western blotting, immunohistochemistry or quantitative proteomics, and gene expression was measured with quantitative RT-PCR. Read More

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http://dx.doi.org/10.1186/s13046-019-1146-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440126PMC
March 2019
1 Read

Tonsillar and Adenoid Noncaseating, Epithelioid Granulomas in a Young Girl.

J Craniofac Surg 2019 Mar 9. Epub 2019 Mar 9.

Department of Otolaryngology-Head and Neck Surgery, Samson Assuta Ashdod University Hospital, Ben Gurion University Faculty of Health Sciences, Ashdod, Israel.

Waldeyer's lymphatic ring granulomas in children are infrequent, and may represent an underlying systemic disease, often nondiagnosed before adenotonsillectomy is performed. The authors report on a 5-year-old otherwise healthy girl presented with remarkable tonsillar asymmetry as well as adenoid hypertrophy, with no systemic signs or complaints. Adenotonsillectomy was performed to rule out malignancy. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005415DOI Listing
March 2019
1 Read
0.676 Impact Factor

Orphan disease status of cancer cachexia in the USA and in the European Union: a systematic review.

J Cachexia Sarcopenia Muscle 2019 Feb;10(1):22-34

Division of Cardiology and Metabolism, Department of Cardiology & Berlin-Brandenburg Center for Regenerative Therapies (BCRT), DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Charité-Universitätsmedizin Berlin (CVK), Berlin, Germany.

Background: Cachexia has significant impact on the patients' quality of life and prognosis. It is frequently observed in patients with cancer, especially in advanced stages, but prevalence data for the overall population are lacking. Good quality estimates of cancer cachexia in general and for each of the major cancer types would be highly relevant for potential treatment development efforts in this field. Read More

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http://dx.doi.org/10.1002/jcsm.12402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438416PMC
February 2019
2 Reads

Immunological Agents Used in Cancer Treatment.

Eurasian J Med 2019 Feb 30;51(1):90-94. Epub 2018 Nov 30.

Department of Medical Oncology, Atatürk University School of Medicine, Erzurum, Turkey.

Immune checkpoint inhibitors (ICI) are monoclonal antibodies targeting cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed cell death protein-1 (PD-1), or PD-1 ligand (PD-L1). ICI are approved for the treatment of malign melanoma, non-small cell lung cancer, classical Hodgkin lymphoma, head and neck squamous cell carcinoma, urothelial carcinoma, and renal cell carcinoma. They can lead to long-term anti-tumor responses by deactivating the brake mechanism in the immune system. Read More

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http://dx.doi.org/10.5152/eurasianjmed.2018.18194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422631PMC
February 2019
2 Reads

Extranodal NK/T-Cell Lymphoma, Nasal Type in Guatemala: An 86-Case Series Emphasizing Clinical Presentation and Microscopic Characteristics.

Head Neck Pathol 2019 Mar 21. Epub 2019 Mar 21.

Centro Clínico de Cabeza y Cuello, Guatemala City, Guatemala.

Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is a lymphoid malignancy that mainly affects the nasopharynx and is associated with the Epstein-Barr virus (EBV). Increased incidence is seen in some Latin American and Asian countries. In this study, we describe a case series of 86 Guatemalan patients with ENKTCL-NT from a single diagnostic head and neck center. Read More

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http://dx.doi.org/10.1007/s12105-019-01027-zDOI Listing
March 2019
1 Read

Rhinologic manifestations of Burkitt Lymphoma in a pediatric population: Case series and systematic review.

Int J Pediatr Otorhinolaryngol 2019 Mar 13;121:127-136. Epub 2019 Mar 13.

Department of Otolaryngology - Head and Neck Surgery, McGill University, Montreal, Canada. Electronic address:

Introduction: Burkitt lymphoma (BL), an aggressive form of B-cell non-Hodgkin's lymphoma, arising from the nose and paranasal sinuses is relatively rare. It can present with various symptoms leading to potential misdiagnosis and delayed treatment. BL is fatal if left untreated, while early identification and treatment can improve prognosis. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.03.013DOI Listing
March 2019
1 Read

A Supraglottic Mass in a Pediatric Patient: An Unusual Presentation of Lymphoma.

Ann Otol Rhinol Laryngol 2019 Mar 20:3489419838544. Epub 2019 Mar 20.

1 Otolaryngology-Head and Neck Surgery, Madigan Army Medical Center, Tacoma, Washington, USA.

Objective:: To present a case of laryngeal lymphoma in a pediatric patient and perform a literature review of this rare entity.

Patient:: A 13-year-old male presented with a rapidly enlarging right neck mass. Work-up of the neck mass included a computed tomography scan of the neck with contrast and revealed a 2. Read More

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http://dx.doi.org/10.1177/0003489419838544DOI Listing
March 2019
2 Reads

Noncancer mortality among adolescents and young adults with cancer.

Cancer 2019 Mar 20. Epub 2019 Mar 20.

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.

Background: Relative to the general population, cancer patients and survivors may have an elevated risk of mortality from noncancer causes, such as cardiovascular disease and infections, but few studies have examined rates of noncancer mortality among patients diagnosed as adolescents and young adults (AYAs) (ages 15-39 years).

Methods: The Surveillance, Epidemiology, and End Results database was used to identify AYA patients who were diagnosed with a first malignant cancer between 1973 and 2015. Rates of mortality from noncancer causes among AYAs with cancer were compared with those in the general US population using standardized mortality ratios (SMRs), adjusted for age, sex, race, and calendar year. Read More

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http://dx.doi.org/10.1002/cncr.32063DOI Listing
March 2019
1 Read

Unusual presentation for small lymphocytic lymphoma: Case report of a man with bilateral ear involvement and review of the literature.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 14. Epub 2019 Mar 14.

Otorhinolaryngoloy service, department of surgery, centre hospitalier de l'université de Montreal, 1560, Sherbrooke Est, H2L 4M1 Montreal, QC, Canada. Electronic address:

Introduction: Ear involvement by non-Hodgkin lymphoma is quite rare and can be mistaken for other common lesions encountered in otolaryngology. The literature on this subject is also limited.

Case Summary: A 45-year-old man with bilateral ear nodules that progressed over two years. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.10.017DOI Listing
March 2019
7 Reads

Otolaryngologist and pediatric oncologist perspectives on the role of fine needle aspiration in diagnosing pediatric head and neck masses.

Int J Pediatr Otorhinolaryngol 2019 Mar 7;121:34-40. Epub 2019 Mar 7.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, United States. Electronic address:

Objective: To determine how otolaryngologists and pediatric oncologists differ in their initial approach to diagnosing head and neck masses in children and adolescents.

Methods: We designed an electronic 28-question survey consisting of 4 clinical cases and one referral case varying by patient age, history, and physical exam findings. The survey was sent anonymously to pediatric oncologists and otolaryngologists at institutions in the United States and Canada. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193011
Publisher Site
http://dx.doi.org/10.1016/j.ijporl.2019.03.003DOI Listing
March 2019
9 Reads

Extranodal NK/T cell lymphoma, nasal type, with retrobulbar extraconal phlegmon and naso-oral fistula.

BMJ Case Rep 2019 Mar 9;12(3). Epub 2019 Mar 9.

Department of Otolaryngology, Head and Neck Surgery, Barwon Health, Geelong, Victoria, Australia.

Extranodal natural killer (NK-)/T cell lymphoma, nasal type (ENKL), is a rare disease that often mimics rheumatological and infectious conditions and can therefore be difficult to diagnose. The authors present a case of a 55-year-old Vietnamese woman who was misdiagnosed with severe atrophic rhinitis and chronic sinus osteitis. Over a period of 8 months from initial referral, she underwent multiple biopsies and was treated with various antimicrobial regimens until the histopathological diagnosis of ENKL was finally made. Read More

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http://dx.doi.org/10.1136/bcr-2018-227160DOI Listing
March 2019
1 Read

Clinical features and outcome of the patients with sinonasal tract diffuse large B-cell lymphoma in the pre-rituximab and rituximab eras.

Eur J Haematol 2019 Mar 4. Epub 2019 Mar 4.

Department of Oncology, Helsinki University Hospital Comprehensive Cancer Center and Research Program in Applied Tumor Genomics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Purpose: Sinonasal tract diffuse large B-cell lymphoma (SNT-DLBCL), a rare extranodal lymphoma, is not well characterized. We performed a population-based study to determine cell-of-origin, clinical presentation and impact of rituximab (R) and central nervous system (CNS) directed chemotherapy on survival.

Patients And Methods: Patients with SNT-DLBCL were identified from pathology databases. Read More

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http://doi.wiley.com/10.1111/ejh.13225
Publisher Site
http://dx.doi.org/10.1111/ejh.13225DOI Listing
March 2019
7 Reads

Kikuchi-Fujimoto Disease in Michigan: A Rare Case Report and Review of the Literature.

Clin Med Insights Ear Nose Throat 2019 27;12:1179550619828680. Epub 2019 Feb 27.

Department of Otolaryngology/Head and Neck Surgery, McLaren Oakland Hospital, Pontiac, MI, USA.

Background: Kikuchi-Fujimoto Disease (KFD), also known as Histiocytic Necrotizing Lymphadenitis, is a rare cause of prolonged cervical lymphadenopathy in both the pediatric and adult populations. It was first reported in Japan in 1972, and since, this disease has been described worldwide, although most cases have been reported in Asia. The etiology of KFD is not fully understood, although there are 2 theories that are described in detail in this review. Read More

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http://dx.doi.org/10.1177/1179550619828680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393831PMC
February 2019
3 Reads

Skull Base Manifestations of Erdheim-Chester Disease: A Case Series and Systematic Review.

Neurosurgery 2019 Mar 4. Epub 2019 Mar 4.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis. Up to 50% of patients develop central nervous system involvement, and a subset of these patients can present with isolated tumor-like masses.

Objective: To describe the skull base manifestations of ECD with an emphasis on aspects most pertinent to surgeons who may be referred such patients for primary evaluation. Read More

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http://dx.doi.org/10.1093/neuros/nyz027DOI Listing
March 2019
5 Reads

Pleomorphic Mantle Cell Lymphoma of the Tongue Base Presenting With Dysphagia.

Clin Med Insights Ear Nose Throat 2019 24;12:1179550619831058. Epub 2019 Feb 24.

Division of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University, Durham, NC, USA.

Objectives: We aim to increase awareness of pleomorphic mantle cell lymphoma as a rare, but aggressive form of lymphoma with propensity for recurrence in secondary locations.

Methods: We report the case of a 70-year-old man who presented with chronic post-nasal drainage, dysphagia, and voice changes caused by a tongue base mass.

Results: Partial excision and pathology showed a pleomorphic mantle cell lymphoma, and radiation treatment was completed. Read More

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http://dx.doi.org/10.1177/1179550619831058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390209PMC
February 2019
3 Reads

[Effectiveness of P-Gemox chemotherapy combined with radiotherapy in newly diagnosed,stage ⅠE to ⅡE, extranodal nasal type natural killer/T-cell lymphoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;33(2):132-137

The First Clinical Medical College of Lanzhou University.

To investigate the efficacy and safety of pegaspargase, gemcitabine, and oxaliplatin(P-Gemox) chemotherapy combined with radiotherapy in the treatment of newly diagnosed, stage IE to IIE of Extranodal nasal type natural killer/T-cell lymphoma(ENKTL) patients. P-Gemox chemotherapy combined with radiotherapy was used to analyze its clinical value and the factors affecting the prognosis in the treatment of 43 newly diagnosed ENKTL patients. In addition, toxicity related to chemotherapy was assessed. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2019.
Publisher Site
http://dx.doi.org/10.13201/j.issn.1001-1781.2019.02.010DOI Listing
February 2019
5 Reads

Prognostic indicators of survival in sinonasal extranodal natural killer/T-cell lymphoma.

Laryngoscope 2019 Feb 23. Epub 2019 Feb 23.

Department of Otorhinolaryngology-Head and Neck Surgery, Rush Sinus Program, Rush University Medical Center, Rush University Medical Center, Chicago, Illinois, U.S.A.

Objectives: Extranodal natural killer/T-cell lymphoma (ENKTL) is a highly aggressive tumor of the sinonasal tract associated with poor overall survival (OS). This study expands upon epidemiologic, prognostic, and treatment factors for OS and disease-specific survival (DSS), incorporating newly accessible chemotherapy data.

Methods: Retrospective population-based cohort study performed on cases of sinonasal ENKTL identified through the Surveillance, Epidemiology, and End Results database. Read More

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http://dx.doi.org/10.1002/lary.27886DOI Listing
February 2019
2 Reads

Risk of subsequent primary neoplasms in survivors of adolescent and young adult cancer (Teenage and Young Adult Cancer Survivor Study): a population-based, cohort study.

Lancet Oncol 2019 Apr 21;20(4):531-545. Epub 2019 Feb 21.

Centre for Childhood Cancer Survivor Studies, Institute of Applied Health Research, University of Birmingham, Birmingham, UK. Electronic address:

Background: Few studies have investigated the risks of subsequent primary neoplasms after adolescent and young adult (AYA) cancer. We investigated the risks of specific subsequent primary neoplasms after each of 16 types of AYA cancer.

Methods: The Teenage and Young Adult Cancer Survivor Study is a population-based cohort of 200 945 survivors of cancer diagnosed when aged 15-39 years in England and Wales from Jan 1, 1971, to Dec 31, 2006. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30903-3DOI Listing
April 2019
1 Read

Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1-ALK fusion: a case report.

Invest New Drugs 2019 Feb 21. Epub 2019 Feb 21.

Department of Clinical Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681, Japan.

An inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm that typically develops in the lungs and seldom in the head and neck region. It is often related to the anaplastic lymphoma kinase (ALK) fusion gene. Crizotinib, a first-generation ALK inhibitor, has been shown to have a notable response in patients with ALK-positive IMT. Read More

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http://dx.doi.org/10.1007/s10637-019-00742-2DOI Listing
February 2019
5 Reads

Clinical management of localized undifferentiated sinonasal carcinoma: our experience and review of the literature.

Anticancer Drugs 2019 Mar;30(3):308-312

Departments of Head and Neck and Sarcoma Oncology.

Undifferentiated sinonasal carcinoma (SNUC) is defined as a small round blue cell tumor that is immunohistochemically distinct from other sinonasal malignancies, such as lymphoma, mucosal melanoma, nasopharyngeal carcinoma, neuroendocrine carcinoma, and olfactory neuroblastoma. SNUCs are very aggressive malignancies, provoking quick destruction of the splanchnocranium structures. Being a very rare neoplasm, there are no prospective clinical trials assessing their treatment strategies, so lots of data are derived by small retrospective trials. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000707DOI Listing
March 2019
1 Read

Lymphomas of the head and neck region: an update.

Virchows Arch 2019 Feb 18. Epub 2019 Feb 18.

International Head and Neck Scientific Group, Padua, Italy.

The field of haematopathology is rapidly evolving and for the non-specialized pathologist receiving a specimen with the possibility of a lymphoid malignancy may be a daunting experience. The coincidence of the publication, in 2017, of the WHO monographies on head and neck and haematopoietic and lymphoid tumours prompted us to write this review. Although not substantially different from lymphomas elsewhere, lymphomas presenting in this region pose some specific problems and these are central to the review. Read More

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http://dx.doi.org/10.1007/s00428-019-02543-7DOI Listing
February 2019
3 Reads
2.651 Impact Factor

Application of diffusion-weighted MR imaging with ADC measurement for distinguishing between the histopathological types of sinonasal neoplasms.

Clin Imaging 2019 Feb 7;55:76-82. Epub 2019 Feb 7.

Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN, USA. Electronic address:

Purpose: To evaluate the potential contribution of quantitative DWI parameters including ADC and ADC values to help in distinguishing the histopathological types of sinonasal neoplasms.

Methods: This retrospective study included 83 patients (50 males, 33 females; mean age 61 years) with pathologically proven untreated sinonasal neoplasms who have undergone diffusion-weighted MRI imaging from February 2010 to August 2017. Diffusion-weighted MRI was performed on a 3 T unit with b factors of 0 and 1000 s/mm, and ADC maps were generated. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.02.004DOI Listing
February 2019

Extranodal NK/T-cell lymphoma in adolescents: imaging findings of a consecutive 7-year case series.

J Int Med Res 2019 Mar 6;47(3):1210-1220. Epub 2019 Feb 6.

1 Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Objectives: Extranodal NK/T-cell lymphoma is reportedly a rare but emerging type of lymphoma in adolescents. The present study was performed to specify its imaging characteristics.

Methods: Our hospital's picture archiving and communication systems were searched from January 2009 to December 2016. Read More

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http://dx.doi.org/10.1177/0300060518822406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421368PMC
March 2019
2 Reads

The utility of MRI histogram and texture analysis for the prediction of histological diagnosis in head and neck malignancies.

Cancer Imaging 2019 Feb 4;19(1). Epub 2019 Feb 4.

Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-Ku, Sapporo, 0608638, Japan.

Background: To assess the utility of histogram and texture analysis of magnetic resonance (MR) fat-suppressed T2-weighted imaging (Fs-T2WI) for the prediction of histological diagnosis of head and neck squamous cell carcinoma (SCC) and malignant lymphoma (ML).

Methods: The cases of 57 patients with SCC (45 well/moderately and 12 poorly differentiated SCC) and 10 patients with ML were retrospectively analyzed. Quantitative parameters with histogram features (relative mean signal, coefficient of variation, kurtosis and skewness) and gray-level co-occurrence matrix (GLCM) features (contrast, correlation, energy and homogeneity) were calculated using Fs-T2WI data with a manual tumor region of interest (ROI). Read More

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http://dx.doi.org/10.1186/s40644-019-0193-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360729PMC
February 2019

Cancer Site and Adverse Events Induced by Immune Checkpoint Inhibitors: A Retrospective Analysis of Real-life Experience at a Single Institution.

Anticancer Res 2019 Feb;39(2):781-790

Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, U.S.A.

Background: Data on the characteristics of patients who are likely to experience adverse events, both immune-related and non-immune-related, from programmed cell death-1 (PD1) inhibitors are limited.

Patients And Methods: Data from patients who received ≥1 dose of single-agent PD1 inhibitor between August 3, 2011 and August 31, 2016 were obtained from our Institution's pharmacy database. AEs were graded using Common Terminology Criteria for Adverse Events version 4. Read More

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http://dx.doi.org/10.21873/anticanres.13175DOI Listing
February 2019
4 Reads

microRNA-539 functions as a tumor suppressor in papillary thyroid carcinoma via the transforming growth factor β1/Smads signaling pathway by targeting secretory leukocyte protease inhibitor.

J Cell Biochem 2019 Jun 31;120(6):10830-10846. Epub 2019 Jan 31.

Department of Otolaryngology - Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, P. R. China.

Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with growing incidence every year. microRNAs (miRs) are known to regulate the physiological and pathological processes of cancers, such as proliferation, migration, invasion, survival, and epithelial-mesenchymal transition (EMT). Herein, this study aimed to investigate the effect of miR-539 on cell proliferation, apoptosis, and EMT by targeting secretory leukocyte protease inhibitor (SLPI) via the transforming growth factor β1 (TGF-β1)/Smads signaling pathway in PTC. Read More

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http://dx.doi.org/10.1002/jcb.28374DOI Listing
June 2019
3 Reads

[Clinicopathological features of follicular lymphoma in children].

Zhonghua Bing Li Xue Za Zhi 2019 Feb;48(2):132-136

Department of Pathology, the First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, China; Institute of Pathology, China Three Gorges University, Yichang 443003, China.

To investigate the clinicopathologic features of follicular lymphoma (FL) in children. One female and one male patients with FL diagnosed in the First College of Clinical Medical Science, China Three Gorges University and Beijing Friendship Hospital of the Capital University of Medical Science in February 2016 and June 2015 were studied by HE immunohistochemistry, EBER in situ hybridization, IgH and IgK gene rearrangement analysis and IRF4 fusion gene detection. The two patients' age were 6. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.02.011DOI Listing
February 2019
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Identification of a Chemical Modulator of EZH2-mediated Silencing by Cell-based High-throughput Screening Assay.

J Biochem 2019 Jan 25. Epub 2019 Jan 25.

Division of Cancer Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Dysregulation of enhancer of zeste homolog 2 (EZH2), a methyltransferase component of polycomb repressive complex 2 (PRC2), is found in many types of cancers especially those that are highly progressive and aggressive. Specific catalytic inhibitors of EZH2 have high anti-tumor activity, particularly in lymphomas with EZH2 activating mutations. However, the clinical benefits of EZH2 catalytic inhibitors in tumors overexpressing EZH2 are still limited. Read More

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http://dx.doi.org/10.1093/jb/mvz007DOI Listing
January 2019

Immune-related adverse events predict the therapeutic efficacy of anti-PD-1 antibodies in cancer patients.

Eur J Cancer 2019 Mar 22;109:21-27. Epub 2019 Jan 22.

Medical Oncology Department, Instituto de Investigación Sanitaria la Princesa, HU La Princesa, Madrid, Spain. Electronic address:

Background: Cancer immune therapy has shown remarkable benefit in the treatment of a range of cancer types, although it may initiate autoimmune-related disorders in some patients. We have attempted to establish whether the incidence of irAEs after the use of anti-PD-1 antibodies nivolumab or pembrolizumab in advanced malignancies is associated with anti-PD-1 treatment efficacy.

Patients And Methods: We studied patients treated with single-agent nivolumab or pembrolizumab for advanced cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183145
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http://dx.doi.org/10.1016/j.ejca.2018.10.014DOI Listing
March 2019
7 Reads

Risk of cancer in HIV-infected patients in Spain, 2004-2015. The CoRIS cohort study.

Enferm Infecc Microbiol Clin 2019 Jan 22. Epub 2019 Jan 22.

Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital General Universitario de Elche y Universidad Miguel Hernández, Alicante, España.

Introduction: Cancer is a leading cause of death in individuals with HIV.

Methods: The incidence of cancer in HIV patients of the CoRIS cohort in the 2004-2009 and 2010-2015 periods has been analysed and compared to the incidence in the Spanish general population, estimated from data of the Spanish Cancer Registry Network.

Results: Between January 2004 and November 2015, 12,239 patients were included in CoRIS and 338 incident cancer cases were diagnosed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0213005X183038
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http://dx.doi.org/10.1016/j.eimc.2018.11.011DOI Listing
January 2019
9 Reads

Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity.

Oman Med J 2019 Jan;34(1):74-77

Department of Otorhinolaryngology-Head and Neck Surgery, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia.

Mantle cell lymphoma (MCL) is a rare, aggressive subtype of non-Hodgkin lymphoma with a poor prognosis and high recurrence rate. It seldom affects the Waldeyer's ring let alone the nasopharynx. Patients usually present at late stages of the disease leading to poor failure-free and overall survival rates. Read More

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http://omjournal.org/articleDetails.aspx?coType=1&aId=24
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http://dx.doi.org/10.5001/omj.2019.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330188PMC
January 2019
8 Reads

ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions.

Nat Cell Biol 2019 02 21;21(2):179-189. Epub 2019 Jan 21.

MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China.

Loss of TGF-β tumour suppressive response is a hallmark of human cancers. As a central player in TGF-β signal transduction, SMAD4 (also known as DPC4) is frequently mutated or deleted in gastrointestinal and pancreatic cancer. However, such genetic alterations are rare in most cancer types and the underlying mechanism for TGF-β resistance is not understood. Read More

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http://www.nature.com/articles/s41556-018-0264-3
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http://dx.doi.org/10.1038/s41556-018-0264-3DOI Listing
February 2019
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Cyclin-dependent kinase 1 and survivin as potential therapeutic targets against nasal natural killer/T-cell lymphoma.

Lab Invest 2019 Jan 21. Epub 2019 Jan 21.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.

Nasal natural killer/T-cell lymphoma (NNKTL) is closely associated with Epstein-Barr virus (EBV) and is characterized by poor prognosis, resulting from rapid progression of lesions in the affected organs. Recent data have shown that NNKTL is associated with the aberrant expression of cyclin-dependent kinase 1 (CDK1) and its downstream target survivin, but little is known about the functional roles of CDK1 and survivin in NNKTL. In the current study, we show that knockdown of the EBV-encoded oncoprotein latent membrane protein 1 (LMP1) induces downregulation of CDK1 and survivin in NNKTL cells. Read More

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http://dx.doi.org/10.1038/s41374-018-0182-9DOI Listing
January 2019
2 Reads
3.676 Impact Factor

Repairing effect of Schwann cells combined with mesenchymal stem cells on optic nerve injury in rats.

Eur Rev Med Pharmacol Sci 2019 Jan;23(1):277-288

Department of Otolaryngology Head and Neck Surgery, the Affiliated Hospital of Qingdao University, Qingdao, China.

Objective: To investigate the effect and the underlying mechanisms of combined transplantation of Schwann cells (Scs) and Mesenchymal stem cells (MSCs) on optic nerve injury in rats.

Materials And Methods: A total of 160 normal healthy adult rats were randomly divided into 4 groups: optic nerve injury group, optic nerve injury + Sc transplantation group, optic nerve injury + MSC transplantation group and optic nerve injury + Sc + MSC transplantation group. The optic nerve in the left eye of each rat was damaged via clamping to establish a model of optic nerve injury, and the right eye was used as self-control. Read More

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http://www.europeanreview.org/article/16774
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http://dx.doi.org/10.26355/eurrev_201901_16774DOI Listing
January 2019
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MicroRNA-153 affects nasopharyngeal cancer cell viability by targeting TGF-β.

Oncol Lett 2019 Jan 12;17(1):646-651. Epub 2018 Oct 12.

Department of Otolaryngology Head and Neck Surgery, Beijing Army General Hospital, Beijing 100700, P.R. China.

The aim of the present study was to determine the function of microRNA-153 (miR-153) in the viability of nasopharyngeal cancer (NPC) cells and determine the underlying molecular mechanism. The expression of miR-153 in patients with NPC was markedly decreased compared with that in paracarcinoma tissue. miR-153 upregulation observably decreased cell viability, induced apoptosis, increased caspase-3 and -9 activity, and increased the B-cell lymphoma 2 (Bcl-2)-associated X protein/Bcl-2 protein expression ratio in 13-9B cells. Read More

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http://dx.doi.org/10.3892/ol.2018.9570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313159PMC
January 2019
1 Read

Acute Left Internal Carotid Artery and Right Popliteal Artery Occlusion Related to Cisplatin-Gemcitabine Based Chemotherapy.

Case Rep Neurol Med 2018 17;2018:9281918. Epub 2018 Dec 17.

Division of Hematology and Medical Oncology, Einstein Medical Center, Philadelphia, USA.

Objectives: The increased risk of thromboembolic complications with active cancer is well known. We present this case to highlight that chemotherapy may increase the risk of thromboembolic events even further in cancer patients.

Methods: We report a case of a 64-year-old male with Diffuse Large B-Cell Non-Hodgkin's Lymphoma who presented with left-sided headache and right calf pain two weeks after starting Rituximab/Gemcitabine/Cisplatin/Dexamethasone chemotherapy. Read More

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http://dx.doi.org/10.1155/2018/9281918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311804PMC
December 2018
7 Reads

A Survival Analysis of Pediatric Tonsillar Malignancies and Review of a Rare Case.

Int J Pediatr Otorhinolaryngol 2019 Mar 28;118:160-164. Epub 2018 Dec 28.

University of Central Florida College of Medicine, Orlando, FL, USA; Division of Otolaryngology, Nemours Children's Hospital, Orlando, FL, USA. Electronic address:

Objective: To examine the survival of pediatric tonsillar cancer patients and review a rare case of pediatric tonsillar cancer.

Methods: Pediatric patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of tonsillar malignancy using the ICD O-3 tonsil primary site codes of: C09.0, C09. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183064
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http://dx.doi.org/10.1016/j.ijporl.2018.12.033DOI Listing
March 2019
4 Reads

Clinical presentation and characteristics of lymphoma in the head and neck region.

Head Face Med 2019 Jan 3;15(1). Epub 2019 Jan 3.

Department of ENT, Head and Neck Surgery, Klinikum Rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany.

Background: The study analyses clinical characteristics of histologically defined head and neck (H&N) lymphoma to raise the awareness of ENT specialists to the leading symptoms.

Method: From 2003 to 2011, all patients with histologically defined H&N lymphoma from our clinic were evaluated.

Results: This study identified 221 patients with H&N lymphoma comprising 193 non-Hodgkin lymphomas (NHL) and 28 Hodgkin lymphomas (HL). Read More

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https://head-face-med.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13005-018-0186-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317257PMC
January 2019
6 Reads
0.867 Impact Factor

Use of ALK Immunohistochemistry for Optimal Therapeutic Strategy of Pulmonary Large-cell Neuroendocrine Carcinoma and Identification of a Novel Fusion Oncokinase.

Anticancer Res 2019 Jan;39(1):413-420

Department of Diagnostic Pathology and Laboratory Medicine, Kindai University Nara Hospital School of Medicine, Nara, Japan.

Background: Patients with adenocarcinoma of the lung are routinely screened for anaplastic lymphoma kinase (ALK) rearrangement because they can be treated by ALK-specific targeted therapy. The clinical and molecular characteristics of large-cell neuroendocrine carcinoma (LCNEC) associated with ALK rearrangement are still unclear. Herein, we assessed the ALK status in a series of patients with LCNEC by testing methods commonly used for adenocarcinoma. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13127DOI Listing
January 2019
13 Reads