3,602 results match your criteria Lymphomas of the Head and Neck


Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1-ALK fusion: a case report.

Invest New Drugs 2019 Feb 21. Epub 2019 Feb 21.

Department of Clinical Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681, Japan.

An inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm that typically develops in the lungs and seldom in the head and neck region. It is often related to the anaplastic lymphoma kinase (ALK) fusion gene. Crizotinib, a first-generation ALK inhibitor, has been shown to have a notable response in patients with ALK-positive IMT. Read More

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http://dx.doi.org/10.1007/s10637-019-00742-2DOI Listing
February 2019

Clinical management of localized undifferentiated sinonasal carcinoma: our experience and review of the literature.

Anticancer Drugs 2019 Mar;30(3):308-312

Departments of Head and Neck and Sarcoma Oncology.

Undifferentiated sinonasal carcinoma (SNUC) is defined as a small round blue cell tumor that is immunohistochemically distinct from other sinonasal malignancies, such as lymphoma, mucosal melanoma, nasopharyngeal carcinoma, neuroendocrine carcinoma, and olfactory neuroblastoma. SNUCs are very aggressive malignancies, provoking quick destruction of the splanchnocranium structures. Being a very rare neoplasm, there are no prospective clinical trials assessing their treatment strategies, so lots of data are derived by small retrospective trials. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000707DOI Listing

Lymphomas of the head and neck region: an update.

Virchows Arch 2019 Feb 18. Epub 2019 Feb 18.

International Head and Neck Scientific Group, Padua, Italy.

The field of haematopathology is rapidly evolving and for the non-specialized pathologist receiving a specimen with the possibility of a lymphoid malignancy may be a daunting experience. The coincidence of the publication, in 2017, of the WHO monographies on head and neck and haematopoietic and lymphoid tumours prompted us to write this review. Although not substantially different from lymphomas elsewhere, lymphomas presenting in this region pose some specific problems and these are central to the review. Read More

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http://dx.doi.org/10.1007/s00428-019-02543-7DOI Listing
February 2019

Application of diffusion-weighted MR imaging with ADC measurement for distinguishing between the histopathological types of sinonasal neoplasms.

Clin Imaging 2019 Feb 7;55:76-82. Epub 2019 Feb 7.

Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN, USA. Electronic address:

Purpose: To evaluate the potential contribution of quantitative DWI parameters including ADC and ADC values to help in distinguishing the histopathological types of sinonasal neoplasms.

Methods: This retrospective study included 83 patients (50 males, 33 females; mean age 61 years) with pathologically proven untreated sinonasal neoplasms who have undergone diffusion-weighted MRI imaging from February 2010 to August 2017. Diffusion-weighted MRI was performed on a 3 T unit with b factors of 0 and 1000 s/mm, and ADC maps were generated. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.02.004DOI Listing
February 2019

Extranodal NK/T-cell lymphoma in adolescents: imaging findings of a consecutive 7-year case series.

J Int Med Res 2019 Feb 6:300060518822406. Epub 2019 Feb 6.

1 Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Objectives: Extranodal NK/T-cell lymphoma is reportedly a rare but emerging type of lymphoma in adolescents. The present study was performed to specify its imaging characteristics.

Methods: Our hospital's picture archiving and communication systems were searched from January 2009 to December 2016. Read More

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http://dx.doi.org/10.1177/0300060518822406DOI Listing
February 2019
1 Read

The utility of MRI histogram and texture analysis for the prediction of histological diagnosis in head and neck malignancies.

Cancer Imaging 2019 Feb 4;19(1). Epub 2019 Feb 4.

Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-Ku, Sapporo, 0608638, Japan.

Background: To assess the utility of histogram and texture analysis of magnetic resonance (MR) fat-suppressed T2-weighted imaging (Fs-T2WI) for the prediction of histological diagnosis of head and neck squamous cell carcinoma (SCC) and malignant lymphoma (ML).

Methods: The cases of 57 patients with SCC (45 well/moderately and 12 poorly differentiated SCC) and 10 patients with ML were retrospectively analyzed. Quantitative parameters with histogram features (relative mean signal, coefficient of variation, kurtosis and skewness) and gray-level co-occurrence matrix (GLCM) features (contrast, correlation, energy and homogeneity) were calculated using Fs-T2WI data with a manual tumor region of interest (ROI). Read More

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http://dx.doi.org/10.1186/s40644-019-0193-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360729PMC
February 2019

Cancer Site and Adverse Events Induced by Immune Checkpoint Inhibitors: A Retrospective Analysis of Real-life Experience at a Single Institution.

Anticancer Res 2019 Feb;39(2):781-790

Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, U.S.A.

Background: Data on the characteristics of patients who are likely to experience adverse events, both immune-related and non-immune-related, from programmed cell death-1 (PD1) inhibitors are limited.

Patients And Methods: Data from patients who received ≥1 dose of single-agent PD1 inhibitor between August 3, 2011 and August 31, 2016 were obtained from our Institution's pharmacy database. AEs were graded using Common Terminology Criteria for Adverse Events version 4. Read More

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http://dx.doi.org/10.21873/anticanres.13175DOI Listing
February 2019
2 Reads

microRNA-539 functions as a tumor suppressor in papillary thyroid carcinoma via the transforming growth factor β1/Smads signaling pathway by targeting secretory leukocyte protease inhibitor.

J Cell Biochem 2019 Jan 31. Epub 2019 Jan 31.

Department of Otolaryngology - Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, P. R. China.

Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with growing incidence every year. microRNAs (miRs) are known to regulate the physiological and pathological processes of cancers, such as proliferation, migration, invasion, survival, and epithelial-mesenchymal transition (EMT). Herein, this study aimed to investigate the effect of miR-539 on cell proliferation, apoptosis, and EMT by targeting secretory leukocyte protease inhibitor (SLPI) via the transforming growth factor β1 (TGF-β1)/Smads signaling pathway in PTC. Read More

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http://dx.doi.org/10.1002/jcb.28374DOI Listing
January 2019
2 Reads

[Clinicopathological features of follicular lymphoma in children].

Zhonghua Bing Li Xue Za Zhi 2019 Feb;48(2):132-136

Department of Pathology, the First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, China; Institute of Pathology, China Three Gorges University, Yichang 443003, China.

To investigate the clinicopathologic features of follicular lymphoma (FL) in children. One female and one male patients with FL diagnosed in the First College of Clinical Medical Science, China Three Gorges University and Beijing Friendship Hospital of the Capital University of Medical Science in February 2016 and June 2015 were studied by HE immunohistochemistry, EBER in situ hybridization, IgH and IgK gene rearrangement analysis and IRF4 fusion gene detection. The two patients' age were 6. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.02.011DOI Listing
February 2019
1 Read

Identification of a Chemical Modulator of EZH2-mediated Silencing by Cell-based High-throughput Screening Assay.

J Biochem 2019 Jan 25. Epub 2019 Jan 25.

Division of Cancer Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Dysregulation of enhancer of zeste homolog 2 (EZH2), a methyltransferase component of polycomb repressive complex 2 (PRC2), is found in many types of cancers especially those that are highly progressive and aggressive. Specific catalytic inhibitors of EZH2 have high anti-tumor activity, particularly in lymphomas with EZH2 activating mutations. However, the clinical benefits of EZH2 catalytic inhibitors in tumors overexpressing EZH2 are still limited. Read More

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http://dx.doi.org/10.1093/jb/mvz007DOI Listing
January 2019

Immune-related adverse events predict the therapeutic efficacy of anti-PD-1 antibodies in cancer patients.

Eur J Cancer 2019 Jan 22;109:21-27. Epub 2019 Jan 22.

Medical Oncology Department, Instituto de Investigación Sanitaria la Princesa, HU La Princesa, Madrid, Spain. Electronic address:

Background: Cancer immune therapy has shown remarkable benefit in the treatment of a range of cancer types, although it may initiate autoimmune-related disorders in some patients. We have attempted to establish whether the incidence of irAEs after the use of anti-PD-1 antibodies nivolumab or pembrolizumab in advanced malignancies is associated with anti-PD-1 treatment efficacy.

Patients And Methods: We studied patients treated with single-agent nivolumab or pembrolizumab for advanced cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183145
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http://dx.doi.org/10.1016/j.ejca.2018.10.014DOI Listing
January 2019
5 Reads

Risk of cancer in HIV-infected patients in Spain, 2004-2015. The CoRIS cohort study.

Enferm Infecc Microbiol Clin 2019 Jan 22. Epub 2019 Jan 22.

Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital General Universitario de Elche y Universidad Miguel Hernández, Alicante, España.

Introduction: Cancer is a leading cause of death in individuals with HIV.

Methods: The incidence of cancer in HIV patients of the CoRIS cohort in the 2004-2009 and 2010-2015 periods has been analysed and compared to the incidence in the Spanish general population, estimated from data of the Spanish Cancer Registry Network.

Results: Between January 2004 and November 2015, 12,239 patients were included in CoRIS and 338 incident cancer cases were diagnosed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0213005X183038
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http://dx.doi.org/10.1016/j.eimc.2018.11.011DOI Listing
January 2019
4 Reads

Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity.

Oman Med J 2019 Jan;34(1):74-77

Department of Otorhinolaryngology-Head and Neck Surgery, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia.

Mantle cell lymphoma (MCL) is a rare, aggressive subtype of non-Hodgkin lymphoma with a poor prognosis and high recurrence rate. It seldom affects the Waldeyer's ring let alone the nasopharynx. Patients usually present at late stages of the disease leading to poor failure-free and overall survival rates. Read More

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http://omjournal.org/articleDetails.aspx?coType=1&aId=24
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http://dx.doi.org/10.5001/omj.2019.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330188PMC
January 2019
6 Reads

ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions.

Nat Cell Biol 2019 Feb 21;21(2):179-189. Epub 2019 Jan 21.

MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China.

Loss of TGF-β tumour suppressive response is a hallmark of human cancers. As a central player in TGF-β signal transduction, SMAD4 (also known as DPC4) is frequently mutated or deleted in gastrointestinal and pancreatic cancer. However, such genetic alterations are rare in most cancer types and the underlying mechanism for TGF-β resistance is not understood. Read More

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http://www.nature.com/articles/s41556-018-0264-3
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http://dx.doi.org/10.1038/s41556-018-0264-3DOI Listing
February 2019
9 Reads

Cyclin-dependent kinase 1 and survivin as potential therapeutic targets against nasal natural killer/T-cell lymphoma.

Lab Invest 2019 Jan 21. Epub 2019 Jan 21.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.

Nasal natural killer/T-cell lymphoma (NNKTL) is closely associated with Epstein-Barr virus (EBV) and is characterized by poor prognosis, resulting from rapid progression of lesions in the affected organs. Recent data have shown that NNKTL is associated with the aberrant expression of cyclin-dependent kinase 1 (CDK1) and its downstream target survivin, but little is known about the functional roles of CDK1 and survivin in NNKTL. In the current study, we show that knockdown of the EBV-encoded oncoprotein latent membrane protein 1 (LMP1) induces downregulation of CDK1 and survivin in NNKTL cells. Read More

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http://dx.doi.org/10.1038/s41374-018-0182-9DOI Listing
January 2019
1 Read
3.676 Impact Factor

Repairing effect of Schwann cells combined with mesenchymal stem cells on optic nerve injury in rats.

Eur Rev Med Pharmacol Sci 2019 Jan;23(1):277-288

Department of Otolaryngology Head and Neck Surgery, the Affiliated Hospital of Qingdao University, Qingdao, China.

Objective: To investigate the effect and the underlying mechanisms of combined transplantation of Schwann cells (Scs) and Mesenchymal stem cells (MSCs) on optic nerve injury in rats.

Materials And Methods: A total of 160 normal healthy adult rats were randomly divided into 4 groups: optic nerve injury group, optic nerve injury + Sc transplantation group, optic nerve injury + MSC transplantation group and optic nerve injury + Sc + MSC transplantation group. The optic nerve in the left eye of each rat was damaged via clamping to establish a model of optic nerve injury, and the right eye was used as self-control. Read More

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http://www.europeanreview.org/article/16774
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http://dx.doi.org/10.26355/eurrev_201901_16774DOI Listing
January 2019
4 Reads

MicroRNA-153 affects nasopharyngeal cancer cell viability by targeting TGF-β.

Oncol Lett 2019 Jan 12;17(1):646-651. Epub 2018 Oct 12.

Department of Otolaryngology Head and Neck Surgery, Beijing Army General Hospital, Beijing 100700, P.R. China.

The aim of the present study was to determine the function of microRNA-153 (miR-153) in the viability of nasopharyngeal cancer (NPC) cells and determine the underlying molecular mechanism. The expression of miR-153 in patients with NPC was markedly decreased compared with that in paracarcinoma tissue. miR-153 upregulation observably decreased cell viability, induced apoptosis, increased caspase-3 and -9 activity, and increased the B-cell lymphoma 2 (Bcl-2)-associated X protein/Bcl-2 protein expression ratio in 13-9B cells. Read More

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http://dx.doi.org/10.3892/ol.2018.9570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313159PMC
January 2019
1 Read

Acute Left Internal Carotid Artery and Right Popliteal Artery Occlusion Related to Cisplatin-Gemcitabine Based Chemotherapy.

Case Rep Neurol Med 2018 17;2018:9281918. Epub 2018 Dec 17.

Division of Hematology and Medical Oncology, Einstein Medical Center, Philadelphia, USA.

Objectives: The increased risk of thromboembolic complications with active cancer is well known. We present this case to highlight that chemotherapy may increase the risk of thromboembolic events even further in cancer patients.

Methods: We report a case of a 64-year-old male with Diffuse Large B-Cell Non-Hodgkin's Lymphoma who presented with left-sided headache and right calf pain two weeks after starting Rituximab/Gemcitabine/Cisplatin/Dexamethasone chemotherapy. Read More

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http://dx.doi.org/10.1155/2018/9281918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311804PMC
December 2018
3 Reads

A Survival Analysis of Pediatric Tonsillar Malignancies and Review of a Rare Case.

Int J Pediatr Otorhinolaryngol 2019 Mar 28;118:160-164. Epub 2018 Dec 28.

University of Central Florida College of Medicine, Orlando, FL, USA; Division of Otolaryngology, Nemours Children's Hospital, Orlando, FL, USA. Electronic address:

Objective: To examine the survival of pediatric tonsillar cancer patients and review a rare case of pediatric tonsillar cancer.

Methods: Pediatric patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of tonsillar malignancy using the ICD O-3 tonsil primary site codes of: C09.0, C09. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183064
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http://dx.doi.org/10.1016/j.ijporl.2018.12.033DOI Listing
March 2019
2 Reads

Clinical presentation and characteristics of lymphoma in the head and neck region.

Head Face Med 2019 Jan 3;15(1). Epub 2019 Jan 3.

Department of ENT, Head and Neck Surgery, Klinikum Rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany.

Background: The study analyses clinical characteristics of histologically defined head and neck (H&N) lymphoma to raise the awareness of ENT specialists to the leading symptoms.

Method: From 2003 to 2011, all patients with histologically defined H&N lymphoma from our clinic were evaluated.

Results: This study identified 221 patients with H&N lymphoma comprising 193 non-Hodgkin lymphomas (NHL) and 28 Hodgkin lymphomas (HL). Read More

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https://head-face-med.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13005-018-0186-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317257PMC
January 2019
4 Reads
0.867 Impact Factor

Use of ALK Immunohistochemistry for Optimal Therapeutic Strategy of Pulmonary Large-cell Neuroendocrine Carcinoma and Identification of a Novel Fusion Oncokinase.

Anticancer Res 2019 Jan;39(1):413-420

Department of Diagnostic Pathology and Laboratory Medicine, Kindai University Nara Hospital School of Medicine, Nara, Japan.

Background: Patients with adenocarcinoma of the lung are routinely screened for anaplastic lymphoma kinase (ALK) rearrangement because they can be treated by ALK-specific targeted therapy. The clinical and molecular characteristics of large-cell neuroendocrine carcinoma (LCNEC) associated with ALK rearrangement are still unclear. Herein, we assessed the ALK status in a series of patients with LCNEC by testing methods commonly used for adenocarcinoma. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13127DOI Listing
January 2019
6 Reads

Low-Grade Cutaneous B-cell Lymphoma in African American Patients

J Drugs Dermatol 2018 Dec;17(12):1334 - 1337

Introduction: Cutaneous marginal zone lymphoma (CMZL) and cutaneous follicle center lymphoma (CFCL) are rare indolent cutaneous B-cell lymphomas (CBCL). Their incidence in African American (AA) patients is extremely low. While cutaneous T-cell lymphomas appear to be more aggressive in AA individuals, there is no data on the presentation and course of disease of CBCL in this group. Read More

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December 2018
4 Reads

Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study.

Acta Oncol 2019 Feb 26;58(2):227-231. Epub 2018 Dec 26.

a Childhood Cancer Research Group , Danish Cancer Society Research Center , Copenhagen , Denmark.

Background: Hyperthyroidism is a rare disorder which may negatively affect health and quality of life. Its occurrence in childhood cancer survivors has not previously been investigated in detail.

Material And Methods: In the hospital registers of the five Nordic countries, 32,944 childhood cancer survivors and 212,675 population comparisons were followed for the diagnosis of hyperthyroidism. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2018.1
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http://dx.doi.org/10.1080/0284186X.2018.1535187DOI Listing
February 2019
9 Reads

Occult malignancy in pediatric tonsil and adenoid surgeries - A national survey.

Int J Pediatr Otorhinolaryngol 2019 Feb 1;117:171-174. Epub 2018 Dec 1.

Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel; Department of Otolaryngology - Head and Neck Surgery, Galilee Medical Center, Nahariya, Israel. Electronic address:

Objective: To evaluate the incidence of tonsil and adenoid malignancy in pediatric patients in Israel compared to the known literature and to revisit the common practice of routine histopathologic examination of tonsils and adenoids.

Methods: Analysis of the Israel National Cancer Registry data on pediatric tonsil and adenoid malignancies between the years 2005 and 2015, and a systematic literature review of all relevant articles that reported on malignancies amongst pediatric patients who underwent tonsillectomy with or without adenoidectomy.

Results: Only seven cases of tonsillar malignancies were documented out of 152,352 (0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183059
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http://dx.doi.org/10.1016/j.ijporl.2018.11.031DOI Listing
February 2019
5 Reads

Epidemiologic, prognostic, and treatment factors in sinonasal diffuse large B -cell lymphoma.

Laryngoscope 2018 Dec 20. Epub 2018 Dec 20.

Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, U.S.A.

Objectives: To further characterize the epidemiology, prognostic disease-specific factors, and treatment outcomes-including newly available chemotherapy data-for patients with sinonasal diffuse large B-cell lymphoma (DLBCL).

Methods: The Surveillance, Epidemiology, and End Results registry was queried from 1973 to 2015 for patients with DLBCL of the nasal cavity and paranasal sinuses. Demographic and disease parameters were collected. Read More

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http://doi.wiley.com/10.1002/lary.27639
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http://dx.doi.org/10.1002/lary.27639DOI Listing
December 2018
8 Reads

Human papillomavirus and the landscape of secondary genetic alterations in oral cancers.

Genome Res 2019 01 18;29(1):1-17. Epub 2018 Dec 18.

Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Human papillomavirus (HPV) is a necessary but insufficient cause of a subset of oral squamous cell carcinomas (OSCCs) that is increasing markedly in frequency. To identify contributory, secondary genetic alterations in these cancers, we used comprehensive genomics methods to compare 149 HPV-positive and 335 HPV-negative OSCC tumor/normal pairs. Different behavioral risk factors underlying the two OSCC types were reflected in distinctive genomic mutational signatures. Read More

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http://genome.cshlp.org/lookup/doi/10.1101/gr.241141.118
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http://dx.doi.org/10.1101/gr.241141.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314162PMC
January 2019
27 Reads
14.630 Impact Factor

Molecular Biology of EBV in Relationship to HIV/AIDS-Associated Oncogenesis.

Cancer Treat Res 2019 ;177:81-103

Department of Otorhinolaryngology-Head and Neck Surgery and Tumor Virology and Global Cancer Programs, Abramson Cancer Center, Philadelphia, USA.

Herpesvirus-induced disease is one of the most lethal factors which leads to high mortality in HIV/AIDS patients. EBV, also known as human herpesvirus 4, can transform naive B cells into immortalized cells in vitro through the regulation of cell cycle, cell proliferation, and apoptosis. EBV infection is associated with several lymphoma and epithelial cancers in humans, which occurs at a much higher rate in immune deficient individuals than in healthy people, demonstrating that the immune system plays a vital role in inhibiting EBV activities. Read More

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http://link.springer.com/10.1007/978-3-030-03502-0_4
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http://dx.doi.org/10.1007/978-3-030-03502-0_4DOI Listing
January 2019
9 Reads

Extranodal lymphoma of the tongue, a very rare entity-report of two cases with literature review.

Int J Surg Case Rep 2019 30;54:70-74. Epub 2018 Nov 30.

Department of Otorhinolaryngology and Head and Neck Surgery, San Fernando Teaching Hospital, Trinidad and Tobago; Department of Clinical Surgical Science, University of the West Indies, St. Augustine, Trinidad and Tobago.

Background: Lymphomas are malignant neoplasms of the lymphocyte cell lines affecting the lymph nodes, spleen and other nonhemopoietic tissues. Of the extranodal lymphomas found in the head and neck region, 3-5% of malignant lymphomas arise in the oral and paraoral region, mainly from Waldeyer's ring. The involvement of the base of the tongue is extremely rare. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.09.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289947PMC
November 2018
1 Read

Image Quality and ADC Assessment in Turbo Spin-Echo and Echo-Planar Diffusion-Weighted MR Imaging of Tumors of the Head and Neck.

Acad Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

Rationale And Objectives: We aimed to compare the distortion ratio (DR), signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) between turbo spin-echo (TSE)-diffusion-weighted imaging (DWI) and echo-planar imaging (EPI)-DWI of the orofacial region and prove the usefulness of TSE-DWI for the differential diagnosis of orofacial lesions.

Materials And Methods: The DR, SNR, and CNR of both sequences were compared in 42 cases. Then, the apparent diffusion coefficient (ADC) of various orofacial lesions obtained by TSE-DWI was investigated in 143 lesions. Read More

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http://dx.doi.org/10.1016/j.acra.2018.11.016DOI Listing
December 2018
2 Reads

Correction to: Extranodal lymphoma arising within the maxillary alveolus: a systematic review.

Oral Radiol 2018 May;34(2):185

Division of Oral and Maxillofacial Radiology, Faculty of Dentistry, UBC, 2199 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.

Objectives: Extranodal lymphomas affecting the head and neck infrequently arise within the jaw bones. Although clinical examination and conventional radiography may initially suffice for such lesions arising within the mandible, those arising within the maxillary alveolus generally require cross-sectional imaging because of the complex anatomy of this region. This study was performed to determine the prevalence, demographic characteristics, and clinical presentations of these lesions and the imaging modalities used for their diagnosis. Read More

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http://dx.doi.org/10.1007/s11282-018-0312-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096548PMC

Vascular malformation of the sphenoid and temporal bone: A diagnostic dilemma.

Am J Otolaryngol 2018 Sep 18. Epub 2018 Sep 18.

Department of Otolaryngology - Head & Neck Surgery, Emory University, Medical Office Tower (MOT), 9th Floor, 550 Peachtree Street NE, Atlanta, GA 30308, United States of America. Electronic address:

We present a rare case of a vascular anomaly of the sphenoid and temporal bones causing an expandable mass of the temporal region with dependent patient positioning and characteristic osseous changes on imaging. Initial diagnosis considerations included multiple myeloma (MM), fibrous dysplasia (FD), Paget's disease, lymphoma, meningoencephalocele (MEC), and vascular malformation (VaM). VaMs of the head and neck are rare and typically arise in the mandible and maxilla. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960709183085
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http://dx.doi.org/10.1016/j.amjoto.2018.09.013DOI Listing
September 2018
10 Reads

Diffuse Large B Cell Lymphoma of Larynx.

J Assoc Physicians India 2018 May;66(5):91-3

Department of Pathology, Homi Bhabha Cancer Hospital, Sangrur, Punjab (a unit of Tata Memorial Hospital, Mumbai).

Extranodal lymphomas of the larynx are very rare, accounting for less than 1% of laryngeal tumours. This study aims to report a case of diffuse large B cell lymphoma of the larynx treated at a newly commissioned cancer centre in semi-urban part of northern India. The case record of a patient of diffuse large B cell lymphoma of larynx was retrospectively reviewed. Read More

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May 2018
1 Read

Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.

Head Neck Pathol 2018 Nov 22. Epub 2018 Nov 22.

Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.

Head and neck pathology present a unique set of challenges including the morphological diversity of the neoplasms and presentation of metastases of unknown primary origin. The detection of human papillomavirus and Epstein-Barr virus associated with squamous cell carcinoma and newer entities like HPV-related carcinoma with adenoid cystic like features have critical prognostic and management implications. In salivary gland neoplasms, differential diagnoses can be broad and include non-neoplastic conditions as well as benign and malignant neoplasms. Read More

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http://dx.doi.org/10.1007/s12105-018-0988-1DOI Listing
November 2018
10 Reads

Endobronchial ultrasound-guided transbronchial needle aspiration cytology in patients with known or suspected extra-pulmonary malignancies: A cytopathology-based study.

Cytopathology 2019 Jan 21;30(1):82-90. Epub 2018 Dec 21.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the primary modality for mediastinal lymph node staging in lung carcinoma. We aimed to evaluate its utility in extra-pulmonary malignancies (EPM).

Methods: Database search of EBUS-TBNA aspirations (2013-2017) done in patients with known/suspected EPMs and mediastinal lymphadenopathy/masses was performed. Read More

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http://dx.doi.org/10.1111/cyt.12656DOI Listing
January 2019
4 Reads
1.481 Impact Factor

Non-Hodgkin's Lymphoma of the Middle Ear Presenting as Mastoiditis.

Case Rep Otolaryngol 2018 17;2018:7639784. Epub 2018 Oct 17.

Department of ENT, Zain and Al Sabah Hospitals, Kuwait City, Kuwait.

Lymphoma originating from the middle ear is rare. The diagnosis of lymphoma as with other cancers of the temporal bone is often made late, and this has a negative implication on the treatment and prognosis of the condition. The delay of diagnosis is mainly due to the similar presentation shared with other benign conditions of the middle ear. Read More

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http://dx.doi.org/10.1155/2018/7639784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207856PMC
October 2018
13 Reads

Systemic Diffuse Large B-Cell Lymphoma Presenting as Bilateral Orbital Vasculopathy.

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e6-e8

From the Division of Oculoplastics and Orbit, Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

The authors report a case of a 58-year-old man with bilateral proptosis and signs of orbital inflammation without any associated systemic findings. MRI showed diffuse orbital infiltration. An intraconal orbital biopsy revealed polyclonal lymphoplasmacytic infiltration and non-necrotizing lymphoid small-vessel vasculopathy. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001274DOI Listing
November 2018
5 Reads

Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer.

Oncoimmunology 2018 1;7(9):e1471440. Epub 2018 Aug 1.

National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

Head and neck squamous cell carcinomas (HNSCCs) frequently harbor genomic mutations in cell death pathways. Nearly 30% of HNSCCs overexpress Fas-Associated Death Domain (FADD), with or without BIRC2/3 genes encoding cellular Inhibitor of Apoptosis Proteins 1/2 (cIAP1/2), critical components of the Tumor Necrosis Factor (TNF) Receptor signaling pathways. ASTX660 is a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP under evaluation in a clinical trial for advanced solid tumors and lymphomas. Read More

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1
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http://dx.doi.org/10.1080/2162402X.2018.1471440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209421PMC
August 2018
6 Reads

The pervasive crisis of diminishing radiation therapy access for vulnerable populations in the United States-Part 4: Appalachian patients.

Adv Radiat Oncol 2018 Oct-Dec;3(4):471-477. Epub 2018 Aug 10.

Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida.

Purpose: Compared with the rest of the United States, the population of Appalachia has lower education levels, higher rates of poverty, and limited access to health care. The presence of disparities in radiation therapy (RT) access for Appalachian patients with cancer has rarely been examined.

Methods And Materials: The National Cancer Institute initiatives toward addressing disparities in treatment access for rural populations were examined. Read More

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http://dx.doi.org/10.1016/j.adro.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200890PMC
August 2018
3 Reads

Myeloid Sarcoma of the Paranasal Sinuses in a Patient with Acute Myeloid Leukemia.

Tohoku J Exp Med 2018 10;246(2):141-146

Department of Otolaryngology-Head and Neck Surgery, Tohoku University School of Medicine.

Myeloid sarcoma (MS) is an uncommon extramedullary malignant tumor, and often represents a subgroup of acute myeloid leukemia (AML). MS of paranasal sinus origin is extremely rare. We report an uncommon case of sinonasal MS associated with AML, who was successfully treated with hematopoietic stem-cell transplantation. Read More

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https://www.jstage.jst.go.jp/article/tjem/246/2/246_141/_art
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http://dx.doi.org/10.1620/tjem.246.141DOI Listing
October 2018
12 Reads

Head and Neck Cancer in Haiti: A Case Series from Hopital de L'Universite d'Etat d'Haiti.

Int J Otolaryngol 2018 1;2018:9429287. Epub 2018 Oct 1.

Department of Otolaryngology/Head & Neck Surgery, Stanford University, Stanford, CA, USA.

This manuscript characterizes the demographics, presenting symptoms and risk factors of patients diagnosed with head and neck cancer at Hopital de L'Universite d'Etat d'Haiti (HUEH), Haiti's single largest healthcare facility. We conducted a prospective study of patients who presented to HUEH between January and March of 2016 with a lesion of the head or neck suspicious for cancer. All patients who met eligibility criteria received a biopsy, which was interpreted by a Haitian pathologist and when the specimen was available was confirmed by a team of pathologists from Stanford University. Read More

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http://dx.doi.org/10.1155/2018/9429287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188769PMC
October 2018
5 Reads

Molecular Imaging Using PET/CT for Radiation Therapy Planning for Adult Cancers: Current Status and Expanding Applications.

Int J Radiat Oncol Biol Phys 2018 Nov 21;102(4):783-791. Epub 2018 Mar 21.

Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; School of Cancer Medicine, Latrobe University, Melbourne, Victoria, Australia; Faculty of Medicine, University of Melbourne, Melbourne, Victoria, Australia; Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia.

Accurate tumor delineation is a priority in radiation therapy (RT). Metabolic imaging has a key and evolving role in target volume selection and delineation. This is especially so for non-small cell lung cancer, squamous cell cancer of the head and neck, and lymphoma, for which positron emission tomography/computed tomography (PET/CT) is complimentary to structural imaging modalities, not only in delineating primary tumors, but also often in revealing previously undiagnosed regional nodal disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016183054
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http://dx.doi.org/10.1016/j.ijrobp.2018.03.013DOI Listing
November 2018
7 Reads

Clinicopathological characteristics and prognostic factors for primary thyroid lymphoma: report on 28 Chinese patients and results of a population-based study.

Cancer Manag Res 2018 10;10:4411-4419. Epub 2018 Oct 10.

Department of Head and Neck Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China,

Objectives: Few studies on prognostic indicators for primary thyroid lymphoma (PTL) have been presented due to the uncommon nature of the tumor. This is the first study to explore the independent prognostic factors in the 2 PTL subtypes.

Methods: We retrospectively reviewed 1,653 cases of PTL. Read More

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https://www.dovepress.com/clinicopathological-characteristic
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http://dx.doi.org/10.2147/CMAR.S155170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188115PMC
October 2018
8 Reads

Prolymphocytic transformation of Lymphoplasmacytic lymphoma; an extremely unusual event.

Hum Pathol 2018 Oct 17. Epub 2018 Oct 17.

Department of Pathology and Laboratory Medicine, Hematology/Oncology Division, University of California Irvine (UCI) Medical Center, Orange, California. Electronic address:

Although rare cases of prolymphocytic transformation from splenic B-cell lymphomas and follicular lymphoma have been reported, prolymphocytic transformation from lymphoplasmacytic lymphoma has not been previously reported. We report a case of 76-year old male patient with a history of Waldenström's Macroglobulinemia diagnosed in 2010 and treated with infusion chemotherapy. He was in clinical remission for 5years. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.09.021DOI Listing
October 2018
3 Reads

HIV-related Malignancies and Mimics: Imaging Findings and Management.

Radiographics 2018 Nov-Dec;38(7):2051-2068. Epub 2018 Oct 19.

From the Departments of Diagnostic Radiology (S.J., K.S., A.O., C.T.J., K.M.E.) and Interventional Radiology (N.K.), University of Texas MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030; Department of Diagnostic Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.); Department of Radiology, University of Utah, Salt Lake City, Utah (A.S.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (M.G.L.); and Department of Radiology, University of Missouri Health Care, Columbia, Mo (A.H.G.).

The risk of developing malignancy is higher in patients with human immunodeficiency virus (HIV) infection than in non-HIV-infected patients. Several factors including immunosuppression, viral coinfection, and high-risk lifestyle choices lead to higher rates of cancer in the HIV-infected population. A subset of HIV-related malignancies are considered to be acquired immunodeficiency syndrome (AIDS)-defining malignancies, as their presence confirms the diagnosis of AIDS in an HIV-infected patient. Read More

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http://pubs.rsna.org/doi/10.1148/rg.2018180149
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http://dx.doi.org/10.1148/rg.2018180149DOI Listing
October 2018
20 Reads
2.602 Impact Factor

The role of protein p16 in non-oropharyngeal head and neck squamous cell carcinoma in Southern China.

Oncol Lett 2018 Nov 23;16(5):6147-6155. Epub 2018 Aug 23.

Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.

Cyclin-dependent kinase inhibitor 2A (p16) protein is a surrogate immunohistochemical marker of human papillomavirus infection in oropharynx squamous cell carcinoma (OPSCC). However, the effects of p16 in non-OPSCC require additional analysis. In addition, major gaps remain in the literature, including small volumes of data for China. Read More

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http://dx.doi.org/10.3892/ol.2018.9353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176411PMC
November 2018

Sinonasal cancer in The Netherlands: Follow-up of a population-based study 1989-2014 and incidence of occupation-related adenocarcinoma.

Head Neck 2018 Nov 15;40(11):2462-2468. Epub 2018 Oct 15.

Comprehensive Cancer Centre The Netherlands (IKNL), Department of Research, Utrecht, The Netherlands.

Background: Long-term trends of sinonasal cancer in The Netherlands have been investigated with particular attention on adenocarcinoma for which wood or leather dust is a well-known risk factor.

Methods: All 4345 patients (1989-2014) registered in the Netherlands Cancer Registry were included. Standardized 3-year moving incidence rates per 1 000 000/person-years, and estimated annual percentage change (EAPC) were calculated. Read More

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http://doi.wiley.com/10.1002/hed.25374
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http://dx.doi.org/10.1002/hed.25374DOI Listing
November 2018
8 Reads

Interferon γ suppresses dentin sialophosphoprotein in oral squamous cell carcinoma cells resulting in antitumor effects, via modulation of the endoplasmic reticulum response.

Int J Oncol 2018 Dec 10;53(6):2423-2432. Epub 2018 Oct 10.

Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX 77054, USA.

The expression of proinflammatory cytokines in various malignant neoplasms is widely considered to represent the host immune response to tumor development. The role of interferon (IFN)γ in head and neck squamous cell carcinoma, and its association with endoplasmic reticulum (ER) stress pathways, remains a subject of ongoing investigation. Dentin sialophosphoprotein (DSPP), which is a member of the small integrin‑binding N‑linked glycoproteins family, has been implicated in malignant transformation and invasion of oral squamous cell carcinoma (OSCC). Read More

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http://www.spandidos-publications.com/10.3892/ijo.2018.4590
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http://dx.doi.org/10.3892/ijo.2018.4590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203152PMC
December 2018
4 Reads

Nivolumab for the treatment of hepatocellular carcinoma.

Expert Rev Anticancer Ther 2018 Dec 22;18(12):1169-1175. Epub 2018 Oct 22.

a Medizinische Klinik 1 , Universitätsklinikum Frankfurt, Goethe-Universität , Frankfurt/Main , Germany.

Introduction: T-cell checkpoint inhibition as a cancer treatment approach has been the main breakthrough in cancer treatment during the last years. Since the approval of the first commercial CTLA-4 antibody ipilimumab in 2011 for the treatment of melanoma, research and drug development in this field has accelerated massively. In 2014, the US Food and Drug Administration (FDA) approved the first PD-1 targeting agent, namely pembrolizumab, shortly followed by nivolumab. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737140.2018.1
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http://dx.doi.org/10.1080/14737140.2018.1535315DOI Listing
December 2018
3 Reads

Histopathological pattern of skin cancer in Western region of Saudi Arabia. An 11 years experience.

Saudi Med J 2018 Oct;39(10):994-998

Department of Pathology, Taibah University, Madinah, Kingdom of Saudi Arabia. E-mail.

Objectives: To determine the histopathological pattern of skin cancer in Madinah region of Kingdom of Saudi Arabia (KSA). Methods: This is a retrospective study including all cases with a histological diagnosis of skin cancer diagnosed at the Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia, between January 2006 and December 2017. Data included  age, gender, site and histology of the tumor were collected from histopathological reports and analyzed using Statistical Package for the Social Sciences  (SPSS) Version 21. Read More

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http://dx.doi.org/10.15537/smj.2018.10.22679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201021PMC
October 2018
7 Reads