3,853 results match your criteria Lymphomas of the Head and Neck


Diagnostic and prognostic value of a 7-panel mutation testing in thyroid nodules with indeterminate cytology: the SWEETMAC study.

Endocrine 2020 Jul 7. Epub 2020 Jul 7.

Thyroid and Endocrine Tumors Unit, Institute of Endocrinology, Pitié Salpêtrière Hospital, IUC Sorbonne University, Paris, France.

Purpose: The aim of this prospective study (ClinicalTrials.gov: NCT01880203) was to evaluate the diagnostic and prognostic value of a 7-panel mutation testing in the aspirates of thyroid nodules with indeterminate cytology (IC).

Methods: Eligible patients had a thyroid nodule ≥15 mm with IC (Bethesda III-V) for which surgery had been recommended. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-020-02411-4DOI Listing

Cancer survival in kidney transplant recipients in Ireland.

Nephrol Dial Transplant 2020 Jul 8. Epub 2020 Jul 8.

Department of Nephrology & Transplantation, Beaumont Hospital, Dublin, Ireland.

Background: Transplantation is a well-known risk factor for malignancy. However, outcomes of cancer in transplant recipients compared with non-transplant recipients are less well studied. We aim to study the survival in kidney transplant recipients who develop cancer and compare this with cancer outcomes in the general population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gfaa109DOI Listing

Negative-Pressure Vacuum Therapy for High-Output Chyle Leak Following Neck Dissection.

Innovations (Phila) 2020 Jul 5:1556984520935535. Epub 2020 Jul 5.

The Hebrew University Medical School, Jerusalem, Israel.

Chyle fistula is a challenging complication following neck dissection carrying a high morbidity and mortality rate. Herein we present a challenging case of successful management of high-output left-sided cervical chyle fistula with negative-pressure vacuum (VAC) therapy in a case where all conservative treatments failed. A 40-year-old man with lymphoma and supraglottic carcinoma underwent endoscopic resection and bilateral neck dissections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1556984520935535DOI Listing

A multidisciplinary consensus on the morphological and functional responses to immunotherapy treatment.

Clin Transl Oncol 2020 Jul 4. Epub 2020 Jul 4.

Radiology Department, Ramón y Cajal University Hospital, Madrid, Spain.

The implementation of immunotherapy has radically changed the treatment of oncological patients. Currently, immunotherapy is indicated in the treatment of patients with head and neck tumors, melanoma, lung cancer, bladder tumors, colon cancer, cervical cancer, breast cancer, Merkel cell carcinoma, liver cancer, leukemia and lymphomas. However, its efficacy is restricted to a limited number of cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12094-020-02442-3DOI Listing

Clinical Characteristics of and Cancer Incidence in Children Evaluated for Lymphadenoapthy Referred to Pediatric Oncology Clinics.

Sisli Etfal Hastan Tip Bul 2020 10;54(2):222-226. Epub 2019 Oct 10.

Department of Pediatrics, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Objectives: In our study, we aimed to investigate the clinical characteristics and cancer frequency in patients referred to our pediatric oncology outpatient clinic for lymphadenopathy.

Methods: The charts of patients admitted to our pediatric oncology outpatient clinics for lymphadenopathy between January 2014, and December 2016 were retrospectively reviewed in this study. Age, gender, duration of complaints, previous therapies, systemic signs and symptoms, lymph node characteristics and laboratory findings were recorded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14744/SEMB.2018.34603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326673PMC
October 2019

Gallium-67 SPECT-CT for the evaluation of head and neck: preliminary study on maximum standardised uptake value in lesions, and in the parotid and submandibular glands.

Pol J Radiol 2020 6;85:e224-e229. Epub 2020 May 6.

Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan.

Purpose: The aim of this study was to investigate the gallium-67 (Ga) single-photon emission-computed tomography (SPECT-CT) for the evaluation of head and neck, especially maximum standardised uptake value (SUV) in lesions, and in the parotid and submandibular glands.

Material And Methods: Fourteen patients with head and neck lesions who underwent SPECT-CT at 72 hours after injection of Ga were included in this study. The Ga SPECT-CT parameters SUV were compared between the parotid glands and submandibular glands. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/pjr.2020.95458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315049PMC

[Clinicopathological characteristics of pediatric-type follicular lymphomas: an analysis of 37 cases].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):681-685

Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

To study the clinicopathologic features, immunophenotype and prognosis of pediatric-type follicular lymphoma (PTFL). Thirty-seven cases of PTFL at the Beijing Friendship Hospital, Capital Medical University, from January 2012 to March 2018 were analyzed using light microscopy, immunohistochemistry, and polymerase chain reaction (PCR), and 13 cases were also examined using fluorescence in situ hybridization (FISH). The male to female ratio was 35∶2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112151-20200214-00096DOI Listing

Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome.

J Exp Med 2020 Oct;217(10)

Institute for Cancer Genetics, Columbia University, New York, NY.

In response to T cell-dependent antigens, mature B cells are stimulated to form germinal centers (GCs), the sites of B cell affinity maturation and the cell of origin (COO) of most B cell lymphomas. To explore the dynamics of GC B cell development beyond the known dark zone and light zone compartments, we performed single-cell (sc) transcriptomic analysis on human GC B cells and identified multiple functionally linked subpopulations, including the distinct precursors of memory B cells and plasma cells. The gene expression signatures associated with these GC subpopulations were effective in providing a sc-COO for ∼80% of diffuse large B cell lymphomas (DLBCLs) and identified novel prognostic subgroups of DLBCL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20200483DOI Listing
October 2020

FDG PET Hybrid Imaging.

Recent Results Cancer Res 2020 ;216:625-667

Department of Nuclear Medicine, University Medicine Rostock, Gertrudenplatz 1, 18057, Rostock, Germany.

Molecular imaging with positron emission tomography (PET) using tumour-seeking radiopharmaceuticals has gained wide acceptance in oncology with many clinical applications. The hybrid imaging modality PET/CT (computed tomography) allows assessing molecular as well as morphologic information at the same time. Therefore, PET/CT represents an efficient tool for whole-body staging and re-staging within one imaging modality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-42618-7_19DOI Listing
January 2020

Extranodal NK/T Cell Lymphoma, Nasal Type with Palatal Involvement: A Rare Case Report and Literature Review.

Head Neck Pathol 2020 Jun 25. Epub 2020 Jun 25.

Department of Oral Medicine and Pathology, Department of Dentistry, School of Health Sciences, National and Kapodistrian University of Athens, 2 Thivon Street, 11527, Athens, Goudi, Greece.

T-cell lymphomas are infrequently encountered in the head and neck area, with the most common subtype being Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT). ENKTL-NT shows a predilection for midline facial structures presenting with ulcerative destructive lesions, whereas palatal involvement is one of the most prominent signs from the oral cavity. Herein, we describe a case of a 76-year-old Greek man with nasal obstruction and an extensive painful necrotic ulcer with ragged borders on the left distal portion of the soft palate and palatine tonsil of 4-months duration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12105-020-01182-8DOI Listing

Extranodal site of diffuse large B-cell lymphoma and the risk of R-CHOP chemotherapy resistance and early relapse.

Int J Clin Pract 2020 Jun 24:e13594. Epub 2020 Jun 24.

Department of Medicine, Faculty of Medicine, University of Malaya, Malaysia.

Background: About 20% to 30% of diffuse large B-cell lymphoma (DLBCL) patients experience early disease progression despite R-CHOP chemotherapy treatment. Revised-international-prognostic-index-score could risk stratify DLBCL patients but does not identify exactly which patient will be resistant to R-CHOP therapy or experience early relapse.

Aims Of The Study: To analyse pre-treatment clinical features of DLBCL patients that are predictive of R-CHOP therapy resistance and early disease relapse after R-CHOP therapy treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijcp.13594DOI Listing

Cavernous sinus lesions.

Clin Imaging 2020 Jun 18;68:71-89. Epub 2020 Jun 18.

NYU Langone Health, Department of Radiology, New York, NY, United States of America. Electronic address:

The cavernous sinus is a complex structure susceptible to a wide variety of vascular, neoplastic and inflammatory pathologies. Vascular pathologies include ICA aneurysms, carotid-cavernous fistulas, cavernous sinus thrombosis, and cavernous hemangioma. Neoplasms that involve the cavernous sinus include pituitary adenoma, meningioma, schwannoma, lymphoma, perineural tumor spread, metastases, and direct tumor invasion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinimag.2020.06.029DOI Listing

Types of occult cancer in stroke and the relation to smoking.

Acta Neurol Scand 2020 Jun 19. Epub 2020 Jun 19.

Danish Cancer Society Research Center, Bispebjerg University Hospital, Copenhagen, Denmark.

Objectives: Stroke is associated with a higher risk of occult cancer. We studied the types of occult cancer most often associated with stroke.

Materials & Methods: All patients with incident stroke in Denmark 2003-2015 were identified through the Danish Stroke Registry (n=85 893) and matched 1:10 on age and sex to the Danish background population without history of stroke (n=858 740). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ane.13299DOI Listing

Differential diagnosis of sinonasal extranodal NK/T cell lymphoma and diffuse large B cell lymphoma on MRI.

Neuroradiology 2020 Jun 19. Epub 2020 Jun 19.

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.

Purpose: To evaluate whether imaging features on conventional magnetic resonance imaging (MRI) can differentiate sinonasal extranodal natural killer/T cell lymphomas (ENKTL) from diffuse large B cell lymphoma (DLBCL).

Methods: Consecutively, pathology-proven 59 patients with ENKTL and 27 patients with DLBCL in the sinonasal region were included in this study. Imaging features included tumor side, location, margin, pre-contrast T1 and T2 signal intensity and homogeneity, post-contrast enhancement degree and homogeneity, septal enhancement pattern, internal necrosis, mass effect, and adjacent involvements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00234-020-02471-3DOI Listing

Primary Sinonasal Lymphoma: A Rare Cause of Cranial Neuropathies.

Cureus 2020 May 15;12(5):e8135. Epub 2020 May 15.

Medicine/Hematology, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.

Primary sinonasal lymphomas are a rare type of non-Hodgkin lymphoma (NHL) with an overall incidence of about 1% of all head and neck cancers. Diffuse large B-cell lymphoma (DLBCL) is the most common type of NHL and it most commonly occurs in elderly men. The diagnosis of such a lymphoma is difficult because of its varied presentation, which usually occurs late after a significant mass effect has taken place. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294899PMC

Transoral robotic surgery in head and neck district: a retrospective study on 67 patients treated in a single center.

Infect Agent Cancer 2020 15;15:40. Epub 2020 Jun 15.

Maxillofacial & ENT surgery Unit, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", via M. Semmola, Naples, Italy.

Background: The anatomical complexity of the oropharynx and the difficulty in reaching its distal portion have always conditioned the surgical accessibility.Robotic surgery represents an excellent alternative in the treatment of cervico-facial oncological diseases.

Methods: This series comprises all patients managed for head and neck cancer by Trans Oral Robotic Surgery TORS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13027-020-00306-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296635PMC

Shift in indications for radiotherapy during the COVID-19 pandemic? A review of organ-specific cancer management recommendations from multidisciplinary and surgical expert groups.

Authors:
Dirk Vordermark

Radiat Oncol 2020 Jun 3;15(1):140. Epub 2020 Jun 3.

Department of Radiation Oncology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 30, 06120, Halle / Saale, Germany.

To examine, if a shift in indications for radiotherapy is to be expected in the context of the COVID-19 pandemic, the database Pubmed was searched for multidisciplinary or surgical expert recommendations on the role of radiotherapy in modified treatment concepts. Increased use of radiotherapy or chemoradiation instead of surgical treatment was recommended for defined patient groups with head-and-neck cancer, lung cancer, cervix cancer, esophageal cancer and prostate cancer. Omission of radiotherapy was considered in elderly patients with low-risk breast cancer and in early-stage Hodgkin's lymphoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-020-01579-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267761PMC

Vena cava superior syndrome in the children with mediastinal tumors: Single-center experience.

North Clin Istanb 2020 9;7(3):255-259. Epub 2020 Apr 9.

Division of Pediatric Hematology-Oncology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Objective: Vena cava superior syndrome comprises various symptoms of compression of vena cava superior. The results of increased venous pressure in the upper body may cause edema of the head and neck associated with cyanosis, plethora and distended subcutaneous vessels. Vena cava superior syndrome is rare in childhood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14744/nci.2019.46354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251265PMC

Pan‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19.

Int J Oncol 2020 Aug 26;57(2):533-539. Epub 2020 May 26.

Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.

Severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV2) is the cause of a new disease (COVID‑19) which has evolved into a pandemic during the first half of 2020. Older age, male sex and certain underlying diseases, including cancer, appear to significantly increase the risk for severe COVID‑19. SARS‑CoV‑2 infection of host cells is facilitated by the angiotensin‑converting enzyme 2 (ACE‑2), and by transmembrane protease serine 2 (TMPRSS2) and other host cell proteases such as cathepsin L (CTSL). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijo.2020.5071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307597PMC

Second cancer risk after primary cancer treatment with three-dimensional conformal, intensity-modulated, or proton beam radiation therapy.

Cancer 2020 Aug 19;126(15):3560-3568. Epub 2020 May 19.

Department of Radiation Oncology, Stanford University, Stanford, California, USA.

Background: The comparative risks of a second cancer diagnosis are uncertain after primary cancer treatment with 3-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), or proton beam radiotherapy (PBRT).

Methods: Pediatric and adult patients with a first cancer diagnosis between 2004 and 2015 who received 3DCRT, IMRT, or PBRT were identified in the National Cancer Database from 9 tumor types: head and neck, gastrointestinal, gynecologic, lymphoma, lung, prostate, breast, bone/soft tissue, and brain/central nervous system. The diagnosis of second cancer was modeled using multivariable logistic regression adjusting for age, follow-up duration, radiotherapy (RT) dose, chemotherapy, sociodemographic variables, and other factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncr.32938DOI Listing

Inflammatory myofibroblastic tumor in the head and neck-a neoplasm with both tumor features and inflammation.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 May 12. Epub 2020 May 12.

Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Objective: The aim of this study was to unveil the reciprocal relation of tumor characteristics and inflammation in inflammatory myofibroblastic tumor in the head and neck.

Study Design: The study included a retrospective cohort of patients with inflammatory myofibroblastic tumors treated between 2005 and 2017 in a tertiary hospital. Tumor features and inflammation were assessed through the expression of anaplastic lymphoma kinase (ALK), the degree of inflammation and cyclooxygenase-2 (COX-2) expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2020.02.008DOI Listing

Comparison of Clinical Characteristics and Magnetic Resonance Imaging of Salivary Glands With Magnetic Resonance Sialography in Sjögren's Syndrome.

Laryngoscope 2020 May 15. Epub 2020 May 15.

Department of Allergology and Clinical Immunology, Geneva University Hospitals, Geneva, Switzerland.

Objectives/hypothesis: To compare the results of magnetic resonance imaging with magnetic resonance sialography (MRSIAL) and the clinical and laboratory characteristics in a well-characterized cohort of patients with primary or secondary Sjögren's syndrome (SS) meeting the American-European Consensus Group criteria.

Study Design: Retrospective, observational, monocentric study.

Methods: Thirty-six patients (81% female, mean age = 48 ± 35 years) with primary or secondary SS who underwent MRSIAL were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.28742DOI Listing

Osteosarcoma of the jaw: report of 3 cases (including the rare epithelioid variant) with review of literature.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 May 11. Epub 2020 May 11.

Department of Pathology, University of New Mexico, School of Medicine, Albuquerque, NM, USA. Electronic address:

Osteosarcoma of the jaw (OSJ) is a rare malignancy, accounting for less than 1% of head and neck malignancies. OSJ can arise as a primary malignancy or secondary to locoregional radiation treatment. Radiologically, these tumors show large, destructive growth with periosteal reaction, which can suggest the diagnosis of osteosarcoma (OS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2020.03.044DOI Listing

Cancer incidence attributable to tuberculosis in 2015: global, regional, and national estimates.

BMC Cancer 2020 May 12;20(1):412. Epub 2020 May 12.

Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Background: Tuberculosis is associated with increased risk of cancer. However, the impact of tuberculosis on global cancer burden is unknown.

Methods: We performed random-effects meta-analyses and meta-regressions of studies reporting the association between tuberculosis and cancer risks by searching PubMed, Web of Science, Embase, Cochrane library, and CINAHL from inception to 1 June 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-020-06891-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218646PMC
May 2020
3.362 Impact Factor

Primary Presentation of Pediatric Hematopoietic Malignancy in the Temporal Bone: Case Report and Review of the Literature.

Ear Nose Throat J 2020 May 8:145561320924146. Epub 2020 May 8.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of New Mexico Hospital, NM, USA.

Malignancy of hematopoietic origin comprises a large portion of all pediatric malignancies; however, it is uncommon for patients with this condition to present only with symptoms related to temporal bone involvement. Here, we report a case of Burkitt Lymphoma of the temporal bone in an 8-year-old patient who initially presented with symptoms of acute otitis media. Additionally, we review the current literature on pediatric hematopoietic malignancy with primary temporal bone involvement and discuss the clinical presentation, management, and outcomes of these rare cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0145561320924146DOI Listing
May 2020
0.881 Impact Factor

Plasmablastic lymphoma as a manifestation of the human immunodeficiency virus: Case report.

J Clin Exp Dent 2020 Apr 1;12(4):e429-e432. Epub 2020 Apr 1.

Hospital El Carmen Dr. Luis Valentin Ferrada, Maipú, Chile.

Plasmablastic lymphoma is a rare subtype of non-Hodgkin's lymphoma, which generally presents an aggressive clinical course and low survival rates. It is strongly associated with HIV infection and the most common site of involvement of the territory of the head and neck is Waldeyer's lymphatic ring, followed by the gastrointestinal tract, lymph nodes and skin. The morphological characteristics of PBL in the oral cavity / jaw in the context of HIV infection show diffuse sheets of large immunoblastic cells with abundant cytoplasm, vesicular chromatin and prominent nucleus, a small located in the center with plasma cells differentiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4317/jced.56482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195680PMC

The Value of CEUS in Distinguishing Cancerous Lymph Nodes From the Primary Lymphoma of the Head and Neck.

Front Oncol 2020 21;10:473. Epub 2020 Apr 21.

Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.

The purpose of this study was to assess the ability of contrast-enhanced ultrasonography (CEUS) in the differential diagnosis of cancerous lymph nodes. Contrast-enhanced ultrasonography was performed in the cervical nodules of included patients, and the diagnoses were confirmed by pathological examination. Contrast-enhanced ultrasonography images and parameters of head and neck lymphomas were compared with those of cancerous lymph nodes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2020.00473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186353PMC

Treatment Response Monitoring in Patients with Advanced Malignancies Using Cell-Free SHOX2 and SEPT9 DNA Methylation in Blood: An Observational Prospective Study.

J Mol Diagn 2020 Jul 30;22(7):920-933. Epub 2020 Apr 30.

Department of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany. Electronic address:

Patients with incurable cancer usually receive palliative treatment with significant toxicity and limited efficacy. Methylation analysis of circulating cell-free DNA (ccfDNA) in blood from cancer patients represents a promising approach for minimally invasive, real-time monitoring of treatment response. Short stature homeobox 2 (SHOX2) and septin 9 (SEPT9) methylation was analyzed in N = 8865 malignant and N = 746 normal adjacent tissues across 33 different malignancies from The Cancer Genome Atlas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2020.04.205DOI Listing

Risk of second primary cancers in individuals diagnosed with index smoking- and non-smoking- related cancers.

J Cancer Res Clin Oncol 2020 Jul 30;146(7):1765-1779. Epub 2020 Apr 30.

Department of Clinical Analytics and Insights, Center for Clinical Excellence, SSM Health, Saint Louis, MO, USA.

Purpose: As the number of cancer survivors in the United States increases, quantifying the risks and burden of second primary cancers (SPCs) among cancer survivors will help develop long-term prevention and surveillance strategies. We describe the risk of developing a SPC among survivors of 10 cancer sites with the highest survival rates in the United States.

Methods: Adult patients diagnosed with an index smoking-related (urinary bladder, kidney and renal pelvis, uterine cervix, oral cavity and pharynx, and colon and rectum) and index non-smoking-related (prostate, thyroid, breast, corpus and uterus, and non-Hodgkin lymphoma) cancers were identified from Surveillance, Epidemiology, and End Results (2000-2015). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-020-03232-8DOI Listing

Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms.

Vet Comp Oncol 2020 Apr 30. Epub 2020 Apr 30.

Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, USA.

Tonsillar metastasis from distant primary tumours has not been described in dogs, and reports are rare in humans. The aims of this study were to determine whether tumour metastasis occurs to the canine palatine tonsils and evaluate whether afferent lymphatics drain to the palatine tonsils via skull indirect computed tomography lymphangiography (ICTL). Retrospective review of the diagnostic laboratory tonsillar histopathology submissions was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vco.12604DOI Listing

Characterization of hepatitis B virus infection and viral DNA integration in non-Hodgkin lymphoma.

Int J Cancer 2020 Apr 29. Epub 2020 Apr 29.

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Hepatitis B virus (HBV) infection has been reported to be associated with non-Hodgkin lymphoma (NHL). However, the evidence is limited to the seroepidemiological study. There is a lack of evidence showing the HBV infection and integration in NHL cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.33027DOI Listing
April 2020
5.085 Impact Factor

Lymphoma Mimicking Chronic Active Epstein-Barr Virus: A Case Report.

Head Neck Pathol 2020 Apr 29. Epub 2020 Apr 29.

Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, Box 1189, One Gustave L Levy Place, NY, 10029, New York, USA.

Epstein-Barr virus (EBV) is the main cause of infectious mononucleosis (IM), a self-limiting infection among immunocompetent patients. EBV is also implicated in the development of several malignancies. We describe a case of a previously healthy 34-year-old man who presented with non-tender, enlarging, right cervical lymphadenopathy for over a year that was associated with significant weight loss, fevers, and night sweats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12105-020-01154-yDOI Listing

Clinical and Histopathological Characteristics of Cutaneous Lymphoid Hyperplasia: A Comparative Study According to Causative Factors.

J Clin Med 2020 Apr 23;9(4). Epub 2020 Apr 23.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Cutaneous lymphoid hyperplasia (CLH) is a heterogeneous type of reactive lymphocytic infiltration resembling cutaneous lymphoma clinically and histopathologically. Few studies describe the relationship between the causative agents and histopathological and immunohistochemical characteristics of CLH. We investigated the clinical and histopathological characteristics of 50 patients with cutaneous CLH and analyzed them according to causative factors and predominant cell types (B or T cells). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9041217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230858PMC

Head and neck squamous cell cancer associated with lymphoproliferative malignancies is aggressive.

J Laryngol Otol 2020 May 20;134(5):460-462. Epub 2020 Apr 20.

Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK.

Background: Patients with non-Hodgkin's lymphoma and chronic lymphocytic leukaemia are at an elevated risk of further malignancy. Head and neck squamous cell carcinoma often presents with cervical lymph node metastasis, and can pose a diagnostic challenge in patients with non-Hodgkin's lymphoma or chronic lymphocytic leukaemia who may have pre-existing palpable neck nodes.

Methods: A retrospective case review of a health board was conducted to identify patients with head and neck squamous cell carcinoma with a previous diagnosis of non-Hodgkin's lymphoma or chronic lymphocytic leukaemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0022215120000729DOI Listing

[Diagnosis, prognosis and treatment of sinonasal carcinomas (excluding melanomas, sarcomas and lymphomas)].

Bull Cancer 2020 May 15;107(5):601-611. Epub 2020 Apr 15.

French Rare Head and Neck Cancer Expert Network, France.

Sinonasal carcinomas account for 3% of ENT cancers. They are subdivided into squamous cell carcinomas (50%), adenocarcinomas [20%, mostly of intestinal type (ITAC)], and more rarely, adenoid cystic carcinomas, olfactory neuroblastomas (=esthesioneuroblastomas), neuroendocrine carcinomas or undifferentiated sinonasal carcinomas (SNUC). The 5-year survival rates are, in descending order, 72% for neuroblastomas, 63% for adenocarcinomas, 50-60% for large-cell neuroendocrine carcinomas, 53% for squamous cell carcinomas, 25-50% for adenoid cystic, 35% for small-cell neuroendocrine carcinomas and 35% for SNUC and newly discovered histologies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bulcan.2020.02.013DOI Listing
May 2020
0.635 Impact Factor

Efficacy of B7-H3-Redirected BiTE and CAR-T Immunotherapies Against Extranodal Nasal Natural Killer/T Cell Lymphoma.

Transl Oncol 2020 May 13;13(5):100770. Epub 2020 Apr 13.

Department of Otolaryngology, Head and Neck Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan province, PR China. Electronic address:

Extranodal nasal natural killer (NK)/T cell lymphoma (ENKTCL) is a rare but highly aggressive subtype of non-Hodgkin lymphoma (NHL). Nevertheless, despite extensive research, the estimated 5-year overall survival of affected patients remains low. Therefore, new treatment strategies are needed urgently. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tranon.2020.100770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160598PMC

Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorders: A Clinical, Pathologic, and Molecular Study of 60 Cases Presenting With a Single Lesion: A Multicenter Study of the French Cutaneous Lymphoma Study Group.

Am J Surg Pathol 2020 Jul;44(7):862-872

INSERM U1053 Team 3 Oncogenesis of Cutaneous Lymphomas, Bordeaux Univsersity, Bordeaux.

Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder (PCSMLPD) is a recently recognized entity in the 2017 World Health Organization (WHO) classification. It belongs to the T-follicular helper (TFH) lymphoproliferations. The clinical, pathologic, and molecular features of this localized disease are underresearched. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001470DOI Listing

-induced follicular mucinosis of the head and neck mimicking folliculotropic mycosis fungoides.

JAAD Case Rep 2020 Apr 24;6(4):266-272. Epub 2020 Mar 24.

Columbia University Irving Medical Center, Department of Dermatology, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2020.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109359PMC

PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer.

Comput Struct Biotechnol J 2020 19;18:668-675. Epub 2020 Mar 19.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Microsatellite instability (MSI) is a genomic property of the cancers with defective DNA mismatch repair and is a useful marker for cancer diagnosis and treatment in diverse cancer types. In particular, MSI has been associated with the active immune checkpoint blockade therapy response in cancer. Most of computational methods for predicting MSI are based on DNA sequencing data and a few are based on mRNA expression data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.csbj.2020.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113609PMC

Erratum: Primary cardiac lymphoma mimicking atrial myxoma in an HIV and EBV-positive patient: a case report.

Int J Clin Exp Pathol 2019;12(3):1115. Epub 2019 Mar 1.

Department of Pathology, Xiangya Hospital, Central South University Changsha, Hunan, People's Republic of China.

[This corrects the article on p. 5497 in vol. 11, PMID: 31949636. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090247PMC

Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status.

Diagn Pathol 2020 Apr 1;15(1):30. Epub 2020 Apr 1.

Department of Pathology and Otolaryngology, UC Irvine School of Medicine, UC Irvine Medical Center, Irvine, USA.

Objectives: Non-Hodgkin's lymphoma (NHL) primarily derived from the base of the tongue, is rare. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. This study describes the clinicopathological features of NHL in the tongue base and the status of HPV and EBV in these cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13000-020-00936-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110811PMC

Evaluation of the introduction of a 'traffic light protocol' for dose-volume histogram constraints of organs at risk in definitive radiotherapy at Liverpool and Macarthur Cancer Therapy Centres.

J Med Imaging Radiat Oncol 2020 Jun 31;64(3):427-434. Epub 2020 Mar 31.

Radiation Oncology, Liverpool Cancer Therapy Centre, Sydney, New South Wales, Australia.

Introduction: Protocols have been developed in our department with recommended dose constraints for organs at risk (OAR) for each tumour site receiving definitive radiotherapy. We have developed a colour coding system to indicate when constraints are meeting objectives (green), have minor variation from planning objectives (yellow) and have major variation from planning objectives (red). We performed a quality audit to assess adherence to the protocol and to determine the rate of acute and subacute toxicities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1754-9485.13023DOI Listing

Apatinib Inhibits Cell Proliferation and Induces Autophagy in Human Papillary Thyroid Carcinoma via the PI3K/Akt/mTOR Signaling Pathway.

Front Oncol 2020 11;10:217. Epub 2020 Mar 11.

Key Laboratory of Cancer Prevention and Therapy, Department of Thyroid and Neck Tumor, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Patients with metastatic radioiodine-refractory papillary thyroid carcinoma (PTC) have limited treatment options and a poor prognosis. There is an urgent need to develop new drugs targeting PTC for clinical application. Apatinib, a novel small-molecule tyrosine kinase inhibitor (TKI), is highly selective for vascular endothelial growth factor receptor-2 (VEGFR2) and exhibits antitumor effects in a variety of solid tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2020.00217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078169PMC

Over expression of CDK4 and MDM2 in a patient with recurrent ALK-negative mediastinal inflammatory myofibroblastic tumor: A case report.

Medicine (Baltimore) 2020 Mar;99(12):e19577

Division of Hematology and Medical Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.

Rationale: The diagnosis of anaplastic lymphoma kinase (ALK)-negative inflammatory myofibroblastic tumors (IMT) remains challenging because of their morphological resemblance with spindle cell sarcoma with myofibroblastic characteristics.

Patient Concerns: A 69-year-old female patient presented with loco-regional recurrent IMT several times within 8 years after primary treatment and neck lymph node metastasis 3.5 years after last recurrence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000019577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220190PMC

Diffused mixed B-cell non-Hodgkin lymphoma of mandible.

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S77-S81. Epub 2020 Feb 28.

Department of Oral Pathology, MM College of Dental Sciences and Research, Ambala, Haryana, India.

Lymphomas are the third-most common cancer of the oral cavity after squamous cell carcinomas and salivary gland tumors. It is characterized by proliferation of lymphoid cells and their precursor. Diffuse B-cell non-Hodgkin lymphoma is the most common histological type of lymphoma in the head-and-neck region and most commonly affects older men in their seventh decade of life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jomfp.JOMFP_310_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069130PMC
February 2020

Spatiotemporal Changes in Checkpoint Molecule Expression.

Adv Exp Med Biol 2020 ;1248:167-200

Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Immune checkpoint inhibitors (ICIs), particularly PD-1/PD-L1 blockade, have led to therapeutic breakthrough in patients with advanced malignancy, covering the lung, breast, gastrointestinal, head and neck, urinary system, lymphoma, and solid tumor harboring MSI/dMMR. In certain cancer types, the expression level of immune checkpoint molecule will be required if the immune-based approaches are considered, especially the PD-L1 expression. However, in other types, survival benefit has been proven regardless of PD-L1 expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-981-15-3266-5_8DOI Listing

High-grade B-cell Lymphoma with and Rearrangement Arising from Follicular Lymphoma: Presentation as a Large Peripancreatic Mass.

Diagnostics (Basel) 2020 Mar 14;10(3). Epub 2020 Mar 14.

Department of Pathology, University of California, Irvine, CA 92868, USA.

Follicular lymphoma, the second most common non-Hodgkin lymphoma (NHL), primarily affects adults and shows an indolent clinical course. Rare cases of follicular lymphoma transform to a high-grade B-cell lymphoma with and rearrangements or "double-hit lymphoma". Transformation to a "double-hit lymphoma" portends a worse prognosis and requires aggressive treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/diagnostics10030157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151221PMC

Comprehensive metagenomic analysis of blastic plasmacytoid dendritic cell neoplasm.

Blood Adv 2020 Mar;4(6):1006-1011

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a hematologic malignancy believed to originate from plasmacytoid dendritic cells (pDCs), the immune cells responsible for producing type 1 interferons during infection. Nearly all patients with BPDCN have prominent skin involvement, with cutaneous infiltration occupying the dermis and subcutis. One half of patients present with BPDCN cells only in the skin, with no evidence of disease elsewhere. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/bloodadvances.2019001260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094006PMC

Lymphoma on the Nasal Dorsum: Report of a Rare Case.

Indian J Dermatol 2020 Mar-Apr;65(2):145-147

Department of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin University, Changchun, Jilin Province, China.

Lymphoma over the nasal dorsum has never been reported. Herein, we report the case of a 74-year-old man who presented with a rapid swelling on the nasal dorsum. A physical examination revealed a firm, immobile, non-tender mass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijd.IJD_559_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059467PMC