259,732 results match your criteria Lymphomas Endocrine Mesenchymal and Other Rare Tumors of the Mediastinum


Critical Review of Styrene Genotoxicity Focused on the Mutagenicity/Clastogenicity Literature and Using Current OECD Guidance.

Environ Mol Mutagen 2019 Feb 20. Epub 2019 Feb 20.

Ramboll, 124 West Capitol Avenue, Suite 1605, Little Rock, AR 72201, USA.

Styrene is an important high production volume chemical used to manufacture polymeric products. In 2018, IARC classified styrene as probably carcinogenic to humans; NTP lists styrene as reasonably anticipated to be a human carcinogen. The genotoxicity literature for styrene and its primary metabolite, styrene 7,8-oxide (SO), begins in the 1970s. Read More

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http://dx.doi.org/10.1002/em.22278DOI Listing
February 2019

Ibrutinib increases the risk of hypertension and atrial fibrillation: Systematic review and meta-analysis.

PLoS One 2019 20;14(2):e0211228. Epub 2019 Feb 20.

Serviço de Cardiologia, Hospital Universitário de Santa Maria (CHLN), CAML, Centro Cardiovascular da Universidade de Lisboa-CCUL, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Lisboa, Portugal.

Introduction: Ibrutinib is an oral covalent inhibitor of Bruton's tyrosine kinase approved for the treatment of patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma and Waldenstrӧm's macroglobulinemia. Ibrutinib has an increased risk of atrial fibrillation but the mechanism is unknown, and hypertension may play a role in the pathogenesis of this adverse drug reaction.

Methods: We aimed to review the risk of hypertension and atrial fibrillation as adverse events associated with ibrutinib through a systematic review with meta-analysis of randomized controlled trials (RCTs) retrieved in December 2018 on MEDLINE, EMBASE, CENTRAL and ClinicalTrials. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211228PLOS
February 2019
3.234 Impact Factor

Radiotherapy or Autologous Stem-Cell Transplantation for Primary CNS Lymphoma in Patients 60 Years of Age and Younger: Results of the Intergroup ANOCEF-GOELAMS Randomized Phase II PRECIS Study.

J Clin Oncol 2019 Feb 20:JCO1800306. Epub 2019 Feb 20.

3 Institut Curie, Site Saint-Cloud, Saint-Cloud, France.

Purpose: To determine the efficacy and toxicity of chemoimmunotherapy followed by either whole-brain radiotherapy (WBRT) or intensive chemotherapy and autologous stem-cell transplantation (ASCT) as a first-line treatment of primary CNS lymphoma (PCNSL).

Patients And Methods: Immunocompetent patients (18 to 60 years of age) with untreated PCNSL were randomly assigned to receive WBRT or ASCT as consolidation treatment after induction chemotherapy consisting of two cycles of R-MBVP (rituximab 375 mg/m day (D) 1, methotrexate 3 g/m D1; D15, VP16 100 mg/m D2, BCNU 100 mg/m D3, prednisone 60 mg/kg/d D1-D5) followed by two cycles of R-AraC (rituximab 375 mg/m D1, cytarabine 3 g/m D1 to D2). Intensive chemotherapy consisted of thiotepa (250 mg/m/d D9; D8; D7), busulfan (8 mg/kg D6 through D4), and cyclophosphamide (60 mg/kg/d D3; D2). Read More

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http://dx.doi.org/10.1200/JCO.18.00306DOI Listing
February 2019

Ruxolitinib treatment reduces monocytic superoxide radical formation without affecting hydrogen peroxide formation or systemic oxidative nucleoside damage in myelofibrosis.

Leuk Lymphoma 2019 Feb 20:1-9. Epub 2019 Feb 20.

b Institute for Inflammation Research (IIR), Center for Rheumatology and Spine Diseases, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.

The role of excess reactive oxygen species (ROS) with consequent DNA/RNA damage is now recognized as a hallmark of cancer. In JAK2V617F mutated myeloproliferative neoplasms, ROS have been suggested to be important factors in disease initiation and progression. Ruxolitinib is the most widely used drug for myelofibrosis, because it improves symptom-score. Read More

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http://dx.doi.org/10.1080/10428194.2019.1579323DOI Listing
February 2019

Mass Cytometry Analysis Reveals that Specific Intratumoral CD4 T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma.

Cell Rep 2019 Feb;26(8):2178-2193.e3

Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address:

Follicular lymphoma (FL) is an indolent B cell malignancy characterized by an extensive but poorly functional T cell infiltrate in the tumor microenvironment. Using mass cytometry, we identified at least 12 subsets of intratumoral CD4 T cells, 3 of which were unique to FL biopsies versus control tissues. Of these subsets, the frequency of naive T cells correlated with improved patient survival. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.085DOI Listing
February 2019

Safety profile of baricitinib in Japanese patients with active rheumatoid arthritis with over 1.6 years median time in treatment: an integrated analysis of Phase 2 and 3 trials.

Mod Rheumatol 2019 Feb 20:1-23. Epub 2019 Feb 20.

g First Department of Internal Medicine , School of Medicine, University of Occupational and Environmental Health , Kitakyushu , Japan.

Objectives: Baricitinib is a selective oral inhibitor of JAK1/JAK2 for patients with moderately-to-severely active rheumatoid arthritis (RA). Baricitinib's safety profile in Japanese patients was evaluated using 6 studies (5 Ph2/Ph3 trials, 1 long-term extension study thru 01-Sept-2016) from an integrated database (9 RA studies).

Methods: Incidence rates (IRs) or exposure-adjusted IRs (EAIRs) of adverse events (AEs) per 100 patient-years (PY) were calculated using data which included RA patients exposed to any baricitinib dose. Read More

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http://dx.doi.org/10.1080/14397595.2019.1583711DOI Listing
February 2019

Hodgkin's lymphoma, nephrotic syndrome, and echinococcosis cysts: an unusual association and literature review.

Pediatr Hematol Oncol 2019 Feb 20:1-6. Epub 2019 Feb 20.

a Pediatrics Department A, Soroka University Medical Center, and Faculty of Health Sciences , Ben-Gurion University of the Negev , Beer Sheva , Israel.

We present a 5-year-old female with minimal change nephrotic syndrome (MCNS). Within several months, she became steroid-dependent with progression of edema and ascites. Imaging studies revealed abnormal solid mass and liver cysts and she was diagnosed with both abdominal Hodgkin's lymphoma (cHD) and large hepatic cystic echinococcosis (CE). Read More

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http://dx.doi.org/10.1080/08880018.2019.1571541DOI Listing
February 2019

Prevalence of pulmonary nodules in dogs with malignant neoplasia as determined by CT.

Vet Radiol Ultrasound 2019 Feb 19. Epub 2019 Feb 19.

Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, United Kingdom.

In order to estimate the prevalence of pulmonary nodules in dogs with nonpulmonary malignant neoplasia, medical record descriptions of CT findings in dogs diagnosed with nonpulmonary malignant neoplasia were reviewed retrospectively. A total of 536 dogs were sampled from a single hospital. For malignant neoplasms with >10 affected individuals, prevalence of multiple pulmonary nodules at first CT was hemangiosarcoma 24 of 58 (41%), osteosarcoma 14 of 55 (26%), carcinoma 20 of 80 (25%), histiocytic sarcoma five of twenty-one (24%), soft tissue sarcoma 13 of 57 (23%), adenocarcinoma 11 of 60 (18%), melanoma five of thirty-seven (14%), lymphoma 10 of 76 (13%), mast cell tumor two of forty-seven (4%), and squamous cell carcinoma zero of seventeen (0%). Read More

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http://dx.doi.org/10.1111/vru.12723DOI Listing
February 2019

Evaluation of duodenal perfusion by contrast-enhanced ultrasonography in dogs with chronic inflammatory enteropathy and intestinal lymphoma.

J Vet Intern Med 2019 Feb 19. Epub 2019 Feb 19.

Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Background: Contrast-enhanced ultrasonography (CEUS) can be used to evaluate intestinal perfusion in healthy dogs. It is helpful for diagnosing and monitoring inflammatory bowel disease in humans and could be useful for dogs with chronic intestinal diseases.

Objectives: To examine duodenal perfusion in dogs with chronic inflammatory enteropathy (CIE) and intestinal lymphoma. Read More

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http://dx.doi.org/10.1111/jvim.15432DOI Listing
February 2019

Short Survival and Frequent Transformation in Extranodal Marginal Zone Lymphoma with Multiple Mucosal Sites Presentation.

Am J Hematol 2019 Feb 19. Epub 2019 Feb 19.

Department of Medicine, Division of Hematology, University of Miami, Miller School of Medicine, Miami, FL, USA.

Between 11-37% of extranodal marginal zone lymphoma (EMZL) patients present with disease involvement in multiple mucosal sites (MMS). We analyzed 405 EMZL patients seen between 1995 and 2017. 265 (65. Read More

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http://dx.doi.org/10.1002/ajh.25446DOI Listing
February 2019

KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR-1470 and epidermal growth factor receptor.

J Cell Physiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China.

Long noncoding RNAs have been reported to play important roles in the pathogenesis of diabetic retinopathy (DR), which has been considered as the most common disease leading to vision loss. However, it is still unclear whether KCNQ1 overlapping transcript 1 (KCNQ1OT1) could affect DR. In this study, regarding quantitative reverse transcription polymerase chain reaction assay, KCNQ1OT1 level was upregulated while microRNA-1470 (miR-1470) was decreased in DR patients and human retinal endothelial cells. Read More

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http://dx.doi.org/10.1002/jcp.28344DOI Listing
February 2019

Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study.

Br J Haematol 2019 Feb 19. Epub 2019 Feb 19.

Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19. Read More

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http://dx.doi.org/10.1111/bjh.15799DOI Listing
February 2019

Lymphoma diagnostics: getting more from less.

Br J Haematol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, University of Utah and ARUP Laboratories, Salt Lake City, UT, USA.

In the modern era, clinicians and pathologists increasingly make challenging diagnoses in patients with suspected lymphoma using minimal amounts of diagnostic material. The increase in utilization of minimally invasive procedures, such as fine needle aspiration or needle core biopsies, lead to challenges in our ability to make accurate histopathological assessments of disease, including the integration of new diagnostic and prognostic testing, with smaller amounts of material. The trend towards minimally invasive diagnostics is also often in conflicting interest with researchers seeking to study tissue specimens to better understand the biology and genetics of these diseases to move the field forward. Read More

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http://dx.doi.org/10.1111/bjh.15788DOI Listing
February 2019

CAR T-Cell Therapy in Non-Hodgkin Lymphoma Patients.

Authors:
Edward A Copelan

Oncology (Williston Park) 2019 Feb 15;33(2). Epub 2019 Feb 15.

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February 2019

Helicobacter pylori infection and gastric cancer biology: tempering a double-edged sword.

Cell Mol Life Sci 2019 Feb 19. Epub 2019 Feb 19.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527, Athens, Greece.

Helicobacter pylori (H. pylori) infection affects an estimated 4.4 billion people globally. Read More

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http://link.springer.com/10.1007/s00018-019-03044-1
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http://dx.doi.org/10.1007/s00018-019-03044-1DOI Listing
February 2019
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HOXA1 upregulation is associated with poor prognosis and tumor progression in breast cancer.

Exp Ther Med 2019 Mar 28;17(3):1896-1902. Epub 2018 Dec 28.

Department of Breast Surgery, Dalian Central Hospital Affiliated to Dalian Medical University, Dalian, Liaoning 116033, P.R. China.

Breast cancer (BC) is the most commonly diagnosed cancer and the second leading cause of cancer-associated mortality among females worldwide. As a member of the homeobox (HOX) gene family, HOXA1 is involved in tumor progression and prognosis in several types of human cancer. However, the clinical significance and biological functions of HOXA1 in BC remains unknown. Read More

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http://dx.doi.org/10.3892/etm.2018.7145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364196PMC

Correlation of the expression of inflammatory factors with expression of apoptosis-related genes and , in burned rats.

Exp Ther Med 2019 Mar 20;17(3):1790-1796. Epub 2018 Dec 20.

Department of Burn Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252601, P.R. China.

Correlation of the expression of inflammatory factors with expression of apoptosis-related genes, B-cell lymphoma 2 () and Bcl-2 associated X protein (), in burned rats was investigated. Forty healthy Sprague-Dawley rats were selected and randomly divided into SHAM group (n=10), I° burn group (n=10), II° burn group (n=10) and III° burn group (n=10). Changes in tumor necrosis factor-α (TNF-α), Bax messenger ribonucleic acid (mRNA), Bcl-2 mRNA, Bax protein and Bcl-2 protein expression levels were detected. Read More

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http://dx.doi.org/10.3892/etm.2018.7118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364214PMC

Downregulation of miR-183 inhibits the growth of PANC-1 pancreatic cancer cells and , and increases chemosensitivity to 5-fluorouracil and gemcitabine.

Exp Ther Med 2019 Mar 19;17(3):1697-1705. Epub 2018 Dec 19.

Department of General Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, P.R. China.

Pancreatic cancer (PC) is a common malignancy with a poorly understood pathogenesis. Currently, the efficacy of anti-PC therapies is insufficient, partially due to the chemoresistance of cancer cells. The present study aimed to elucidate the role of miR-183 in the proliferation, apoptosis, and chemosensitivity to 5-fluorouracil and gemcitabine of human PC cells and the associated mechanisms. Read More

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http://dx.doi.org/10.3892/etm.2018.7112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364144PMC

Novel triazole analogs of apigenin-7-methyl ether exhibit potent antitumor activity against ovarian carcinoma cells via the induction of mitochondrial-mediated apoptosis.

Exp Ther Med 2019 Mar 28;17(3):1670-1676. Epub 2018 Dec 28.

Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

Ovarian cancer is one of the main causes of cancer-associated mortality across the world. Currently, ovarian cancer is mainly treated with chemotherapy. However, ovarian cancer is detected at advanced stages and chemotherapy has numerous side effects. Read More

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http://dx.doi.org/10.3892/etm.2018.7138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364180PMC

Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy combined with ganciclovir induces hepatoma cell apoptosis.

Exp Ther Med 2019 Mar 2;17(3):1649-1655. Epub 2019 Jan 2.

Department of General Surgery, Beijing Youan Hospital, Capital Medical University, Beijing 100069, P.R. China.

The present study aimed to examine the apoptotic effects of adenovirus (ADV)-mediated herpes simplex virus thymidine kinase (ADV-TK) combined with ganciclovir (GCV) in tissues obtained from patients with hepatocellular carcinoma in order to provide a theoretical basis for the development of this gene therapy program. Apoptosis detection was conducted using the terminal deoxynucleotidyl-transferase-mediated dUTP nick end labelling assay and the apoptosis index was compared between the experimental; and control groups. Furthermore, the protein expression levels of caspase-3, B-cell lymphoma-2 (Bcl-2), Bcl-2-assoicated protein X (Bax) and nuclear factor (NF)-κB were examined in pathological specimens using immunohistochemical staining. Read More

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http://dx.doi.org/10.3892/etm.2019.7147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364201PMC

Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology.

Oncogene 2019 Feb 19. Epub 2019 Feb 19.

Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria, Farmacología Molecular y Traslacional - BIOPharm, Las Palmas de G.C., 35016, Las Palmas, Spain.

The signal transducer and activator of transcription (STAT) are transcription factors that work via JAK/STAT pathway regulating the expression of genes involved in cell survival, proliferation, differentiation, development, immune response, and, among other essential biological functions, hematopoiesis. JAK/STAT signaling is strictly regulated under normal physiological conditions. However, a large group of diverse diseases has been associated to an aberrant regulation of STAT factors. Read More

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http://dx.doi.org/10.1038/s41388-019-0752-3DOI Listing
February 2019

Reverse signaling via PD-L1 supports malignant cell growth and survival in classical Hodgkin lymphoma.

Blood Cancer J 2019 Feb 19;9(3):22. Epub 2019 Feb 19.

Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Treatment with programmed death-1 (PD-1) blocking antibodies results in high overall response rates in refractory and relapsed classical Hodgkin lymphoma (cHL) patients, indicating that PD-1/PD-1 ligand interactions are integral to progression of this disease. Given the genetically driven increased PD-L1/2 expression in HL, we hypothesized that reverse signaling through PD-1 ligands may be a potential mechanism contributing to the growth and survival of Hodgkin Reed-Sternberg (HRS) cells in cHL. Our data show that engagement of PD-L1 using an agonistic monoclonal antibody increases cell survival and proliferation and reduces apoptosis in HL cell lines. Read More

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http://dx.doi.org/10.1038/s41408-019-0185-9DOI Listing
February 2019

Primary CNS Lymphoma in the Elderly: The Challenge.

Acta Haematol 2019 Feb 15;141(3):138-145. Epub 2019 Feb 15.

Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.

Primary central nervous system (CNS) lymphoma is an aggressive brain tumor sensitive to chemotherapy and radiotherapy. Its incidence has increased in the elderly, and they account for the majority of patients. The median survival of patients older than 70 years did not change over the last 40 years and remained in the range of 6-7 months. Read More

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http://dx.doi.org/10.1159/000495284DOI Listing
February 2019

Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma.

MBio 2019 Feb 19;10(1). Epub 2019 Feb 19.

UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA

Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). PEL has a highly active mTOR pathway, which makes mTOR a potential therapeutic target. MLN0128 is an ATP-competitive inhibitor of mTOR that has entered clinical trials for solid tumors. Read More

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http://dx.doi.org/10.1128/mBio.02871-18DOI Listing
February 2019

The response to lymphodepletion impacts PFS in aggressive non-Hodgkin lymphoma patients treated with CD19 CAR-T cells.

Blood 2019 Feb 19. Epub 2019 Feb 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.

Factors associated with durable remission after CD19 chimeric antigen receptor (CAR)-modified T cell immunotherapy for aggressive B-cell non-Hodgkin lymphoma (NHL) have not been identified. We report multivariable analyses of factors impacting response and progression-free survival (PFS) in aggressive NHL patients treated with cyclophosphamide and fludarabine (Cy/Flu) lymphodepletion followed by 2x10 CD19 CAR-T cells/kg. The best overall response rate (ORR) was 51%, with 40% of patients achieving complete remission (CR). Read More

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http://dx.doi.org/10.1182/blood-2018-11-887067DOI Listing
February 2019

Viral, immunologic, and clinical features of primary effusion lymphoma.

Blood 2019 Feb 19. Epub 2019 Feb 19.

HIV & AIDS Malignancy Branch, Center for Cancer Research (CCR), NCI, Bethesda, MD, United States;

Primary effusion lymphoma (PEL) is an aggressive HIV-associated lymphoma with a relatively poor prognosis in the era of effective HIV therapy. Kaposi sarcoma herpesvirus (KSHV) is the etiologic agent, and approximately 80% of tumors are Epstein Barr virus (EBV) co-infected. A better understanding of how KSHV-related immune dysregulation contributes to the natural history of PEL will improve outcomes. Read More

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http://dx.doi.org/10.1182/blood-2019-01-893339DOI Listing
February 2019

Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma.

Blood 2019 Feb 19. Epub 2019 Feb 19.

Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States;

Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities, often associated with an aggressive clinical course. Angioimmunoblastic T-cell lymphoma (AITL) and PTCL-not otherwise specified (PTCL-NOS) are the two most frequent categories accounting for more than 50% of PTCLs. Gene expression profiling (GEP) defined molecular signatures for AITL and delineated biological and prognostic subgroups within PTCL-NOS (PTCL-GATA3 and PTCL-TBX21). Read More

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http://dx.doi.org/10.1182/blood-2018-09-872549DOI Listing
February 2019

Gastric MALT lymphoma presented with primary perforation in an adolescent: a case report.

BMC Pediatr 2019 Feb 19;19(1):63. Epub 2019 Feb 19.

Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, 80756, Taiwan.

Background: Primary lymphomas of the gastrointestinal tract are rare, accounting for only 1 to 4% of malignancies arising in the stomach, small intestine, or colon. The stomach is the most common extranodal site of lymphoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma accounts for 40% of primary gastric lymphoma. Gastric MALT lymphoma reaches its peak incidence between 50 to 60 years of age, therefore, it is rarely encountered in pediatric population. Read More

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http://dx.doi.org/10.1186/s12887-019-1431-9DOI Listing
February 2019

New directions in treating peripheral T-cell lymphomas (ptcl): leveraging epigenetic modifiers alone and in combination.

Expert Rev Hematol 2019 Feb 20. Epub 2019 Feb 20.

a Center for Lymphoid Malignancies, Division of Hematology and Oncology, Department of Medicine , Columbia University Medical Center, College of Physicians and Surgeons , New York , N.Y. , USA.

Introduction: The peripheral T-cell lymphomas (PTCL) are a rare and heterogeneous group of non-Hodgkin lymphomas originating from mature T- and NK-cells. They are aggressive diseases often resistant to chemotherapy. Areas Covered: The methodology of this review involves a literature search of data published on PubMed, abstracts from international conferences, and our own research. Read More

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http://dx.doi.org/10.1080/17474086.2019.1583102DOI Listing
February 2019

Baseline PET as prognostic index in diffuse large B-cell lymphoma and grade IIIb follicular lymphoma: a retrospective study of a single-centre experience.

Q J Nucl Med Mol Imaging 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Background: International guidelines support performing baseline positron emission tomography (PET) in lymphoma. Metabolic tumor volume (MTV) measurement has been proposed as a good measurement of disease burden. We investigated if MTV at baseline PET can be predictive of complete response (CR) to first line standard chemotherapy in diffuse large B-cell lymphoma (DLBCL) and in follicular lymphoma (FL) grade 3b. Read More

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http://dx.doi.org/10.23736/S1824-4785.19.03130-3DOI Listing
February 2019

The renoprotective effects of naringin and trimetazidine on renal ischemia/reperfusion injury in rats through inhibition of apoptosis and downregulation of micoRNA-10a.

Biomed Pharmacother 2019 Feb 16;112:108568. Epub 2019 Feb 16.

Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; The Persian Gulf Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Renal Ischemia-Reperfusion (IR) injury occurs due to circulatory shock and renal transplantation, leading to mortality and morbidity worldwide. The primary purpose of the current study was to evaluate the renoprotective effects of the naringin (NAR) and trimetazidine (TMZ) on IR injury, renal hemodynamics, antioxidant capacity, microRNA-10a, and expression of apoptosis factors. Forty rats were divided into five groups randomly: Sham, IR injury, (TMZ, 5 mg/kg), (NAR pretreatment, 100 mg/kg), and TMZ plus NAR. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.029DOI Listing
February 2019

Comparison of outcomes of free-hand 2-dimensional ultrasound-guided versus navigated 3-dimensional ultrasound-guided biopsy for supratentorial tumours: a single-institution experience with 125 cases.

Ultrasonography 2018 Dec 8. Epub 2018 Dec 8.

Division of Neurosurgery, Department of Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.

Purpose: The purpose of this study was to evaluate the relative utility and benefits of free-hand 2-dimensional intraoperative ultrasound (FUS) and navigated 3-dimensional intraoperative ultrasound (NUS) as ultrasound-guided biopsy (USGB) techniques for supratentorial lesions.

Methods: All patients who underwent USGB for suspected supratentorial tumours from January 2008 to December 2017 were retrospectively analyzed. The charts and electronic medical records of these patients were studied. Read More

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http://dx.doi.org/10.14366/usg.18036DOI Listing
December 2018

Epstein-Barr virus-associated gastric ulcer mimicking gastric neoplasia: a case report.

Med Ultrason 2019 Feb;21(1):96-98

Department of Gastroenterology, Regional Institute of Gastroenterology and Hepatology Prof. Dr. Octavian Fodor, Cluj-Napoca, Romania.

We describe a rare case of a severe gastric ulcer of a 66-year-old immunocompetent man who was associated with primary Epstein-Barr virus (EBV) infection and temporarily misdiagnosed with gastric lymphoma. A contrast-enhanced computed tomography (CT-scan) of the thorax, abdomen and pelvis followed by EUS revealed a neoplastic infiltrative-ulcerative semicircumferentialgastric mass and a 1 cm large satellite adenopathy, being classified as T3N1M0 gastric neoplasia. The histological analysis of the ¾ distal stomach and lymph node sthat were resected contradicted the initial biopsy report, suggesting EBV gastric ulcer, etiology confirmed by the in situ hybridization technique. Read More

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http://dx.doi.org/10.11152/mu-1560DOI Listing
February 2019

Human IFIT proteins inhibit lytic replication of KSHV: A new feed-forward loop in the innate immune system.

PLoS Pathog 2019 Feb 19;15(2):e1007609. Epub 2019 Feb 19.

Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.

Kaposi's sarcoma-associated herpesvirus (KSHV) is causally associated with Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The IFIT family of proteins inhibits replication of some viruses, but their effects on KSHV lytic replication was unknown. Here we show that KSHV lytic replication induces IFIT expression in epithelial cells. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007609DOI Listing
February 2019

Clinical management of localized undifferentiated sinonasal carcinoma: our experience and review of the literature.

Anticancer Drugs 2019 Mar;30(3):308-312

Departments of Head and Neck and Sarcoma Oncology.

Undifferentiated sinonasal carcinoma (SNUC) is defined as a small round blue cell tumor that is immunohistochemically distinct from other sinonasal malignancies, such as lymphoma, mucosal melanoma, nasopharyngeal carcinoma, neuroendocrine carcinoma, and olfactory neuroblastoma. SNUCs are very aggressive malignancies, provoking quick destruction of the splanchnocranium structures. Being a very rare neoplasm, there are no prospective clinical trials assessing their treatment strategies, so lots of data are derived by small retrospective trials. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000707DOI Listing

Evaluation of the extent of neoplastic infiltration in small intestinal tumours in dogs.

Vet Med Sci 2019 Feb 19. Epub 2019 Feb 19.

Bridge Pathology Ltd., Bristol, UK.

There is currently a lack of evidence-based guidance when determining surgical margins for small intestinal tumours in dogs. The purpose of this study is to help the surgeon make informed clinical decisions about margins when confronted with a small intestinal mass. Twenty-seven canine small intestinal tumours were histologically diagnosed and then had further histological assessment at every centimeter from the edge of the palpable tumour to the surgical margin in oral, aboral and mesenteric directions. Read More

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http://dx.doi.org/10.1002/vms3.147DOI Listing
February 2019

A recurrent clonally distinct burkitt lymphoma case highlights genetic key events contributing to oncogenesis.

Genes Chromosomes Cancer 2019 Feb 18. Epub 2019 Feb 18.

INSERM U1245, Centre Henri Becquerel and Rouen University, Rouen, France.

Burkitt lymphoma (BL) is characterized by a translocation of the MYC oncogene that leads to the upregulation of MYC expression, cell growth and proliferation. It is well-established that MYC translocation is not a sufficient genetic event to cause BL. Next-generation sequencing has recently provided a comprehensive analysis of the landscape of additional genetic events that contribute to BL lymphomagenesis. Read More

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http://dx.doi.org/10.1002/gcc.22743DOI Listing
February 2019

CD30 expression in a case of intravascular large B-cell lymphoma, cutaneous variant.

J Cutan Pathol 2019 Feb 18. Epub 2019 Feb 18.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.

Intravascular large B-cell lymphoma (IVLBCL) is one of the rarest B-cell non Hodgkin lymphomas (NHL), with an aggressive clinical behavior and a poor prognosis; in fact, its treatment is still an unmet clinical need, with a 3-year overall survival (OS) rate of 60-81%, and a central nervous system relapse rate of 25%. It usually presents as a widespread disease at diagnosis with multi-organ involvement. Previously considered as a diffuse large B-cell lymphoma variant, it now represents a different extranodal large B-cell lymphoma entity in the last WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Read More

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http://dx.doi.org/10.1111/cup.13446DOI Listing
February 2019

Correlations of mouse lymphoma xenografts with the expressions of MMP-9 and Bcl-2.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1176-1183

Department of Hematology, Qingdao Center Hospital, Qingdao, Shandong, P.R. China.

Objective: To establish a mouse lymphoma xenograft model so as to investigate the correlation between the expression of matrix metallopeptidase-9 (MMP-9) and that of B-cell lymphoma 2 (Bcl-2) in lymphomas.

Materials And Methods: Diffuse large Bcl (DLBCL) cells were cultured, and a mouse lymphoma xenograft model was established via the subcutaneous injection. Mouse lymphoma tissues were extracted, and the expressions of MMP-9 and Bcl-2 messenger ribonucleic acids (mRNAs) in the xenograft tumor were detected using Real-time polymerase chain reaction (PCR). Read More

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http://dx.doi.org/10.26355/eurrev_201902_17010DOI Listing
February 2019

Breast cancer in women living with HIV.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1158-1164

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

With the introduction of HAART, the life expectancy of the patients infected with HIV almost approached that of the general population. The incidence of certain HIV-Associated cancers as Kaposi Sarcoma (KS) and Non-Hodgkin Lymphoma (NHL) decreased, while an increase in Non-AIDS-Defining cancers (NADCs) has been documented. HIV infection is a risk factor for numerous cancers in PLWH. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17007DOI Listing
February 2019

Ultrasensitive Detection of Circulating Tumor DNA in Lymphoma via Targeted Hybridization Capture and Deep Sequencing of Barcoded Libraries.

Methods Mol Biol 2019 ;1956:383-435

Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.

Liquid biopsies are rapidly emerging as powerful tools for the early detection of cancer, noninvasive genomic profiling of localized or metastatic tumors, prompt detection of treatment resistance-associated mutations, and monitoring of therapeutic response and minimal residual disease in patients during clinical follow-up. Growing evidence strongly supports the utility of circulating tumor DNA (ctDNA) as a biomarker for the stratification and clinical management of lymphoma patients. However, ctDNA is diluted by variable amounts of cell-free DNA (cfDNA) shed by nonneoplastic cells causing a background signal of wild-type DNA that limits the sensitivity of methods that rely on DNA sequencing. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_20DOI Listing
January 2019

Phosphoproteomic Analysis of Signaling Pathways in Lymphomas.

Methods Mol Biol 2019 ;1956:371-381

Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany.

Cell fate decisions are controlled by complex signal transduction processes that transmit information via posttranslational protein modifications such as phosphorylation. In lymphoma, as in other cancer types, these signaling networks are often dysregulated and thus contribute to malignant transformation and tumor maintenance. For example, B-cell antigen receptor signals are rewired in certain lymphoma types, such as diffuse large B-cell lymphomas, to promote cell growth and survival of the malignant cell clones. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_19DOI Listing
January 2019

Proximity Ligation Assay.

Authors:
Ryan M Young

Methods Mol Biol 2019 ;1956:363-370

Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Many methods exist to study oncogenic signaling in lymphoma cells, each with certain strengths and weaknesses. The proximity ligation assay (PLA) is a technique used to examine protein-protein interactions in situ. PLA offers many advantages over traditional biochemical approaches to signaling in that it can detect both transient interactions, which are hard to capture otherwise, as well as protein interactions within large supramolecular signaling platforms that are often intractable to traditional biochemical methodologies. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_18DOI Listing
January 2019

Lymphoma and Leukemia Cell Vulnerabilities and Resistance Identified by Compound Library Screens.

Methods Mol Biol 2019 ;1956:351-362

Department of Haematology, Center for Oncology and Haematology, University Hospital and University of Zurich, Zurich, Switzerland.

Response to anticancer agents is often restricted to subsets of patients. The recognition of factors underlying this heterogeneity and the identification of biomarkers associated with response to drugs would greatly improve the efficacy of drug treatment. Platforms that can comprehensively map drug response in high-throughput ex vivo provide a unique tool to identify associated biomarkers and provide hypotheses for mechanisms underlying variable response. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_17DOI Listing
January 2019

Protocols for CRISPR-Cas9 Screening in Lymphoma Cell Lines.

Methods Mol Biol 2019 ;1956:337-350

Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Genome-wide screens are a powerful technique to dissect the complex network of genes regulating diverse cellular phenotypes. The recent adaptation of the CRISPR-Cas9 system for genome engineering has revolutionized functional genomic screening. Here, we present protocols used to introduce Cas9 into human lymphoma cell lines, produce high-titer lentivirus of a genome-wide sgRNA library, transduce and culture cells during the screen, isolate genomic DNA, and prepare a custom library for next-generation sequencing. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_16DOI Listing
January 2019

Evaluation of Whole Genome Sequencing Data.

Methods Mol Biol 2019 ;1956:321-336

Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Whole genome sequencing (WGS) can provide comprehensive insights into the genetic makeup of lymphomas. Here we describe a selection of methods for the analysis of WGS data, including alignment, identification of different classes of genomic variants, the identification of driver mutations, and the identification of mutational signatures. We further outline design considerations for WGS studies and provide a variety of quality control measures to detect common quality problems in the data. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_15DOI Listing
January 2019