261,485 results match your criteria Lymphomas Endocrine Mesenchymal and Other Rare Tumors of the Mediastinum


Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, 475000, Henan, China. Electronic address:

Rheumatoid arthritis fibroblast-like synoviocytes play an essential role in the occurrence and progression of rheumatoid arthritis. As the main pharmacologically active components of Aralia taibaiensis, total saponins, particularly triterpenoid saponins, have been shown to possess multiple pharmacological activities including relieving rheumatism. However, the effect of araloside A, a triterpenoid saponin extracted from the root bark of Aralia taibaiensis, on rheumatoid arthritis remains unknown. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.025DOI Listing

Lymph node fine-needle cytology in the era of personalized medicine. Is there a role?

Cytopathology 2019 Apr 20. Epub 2019 Apr 20.

Universita degli Studi di Salerno, Medicine and Surgery, Fisciano, Campania, IT.

The 2016 WHO revised classification of lymphoma has sub-classified well defined entities and added a number of provisional entities on the basis of new knowledge on genetic, epigenetics and phenotypical data; prognostic and predictive features are also part of this classification. New knowledge on well-defined entities further enlightens the mechanisms of lymphomagenesis, which are more complex and multifactorial than once believed. Therapies are also more complex because traditional clinical trials have been integrated with new drugs and compounds with unique mechanisms of actions against distinct molecular targets. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cyt.12708
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http://dx.doi.org/10.1111/cyt.12708DOI Listing
April 2019
1 Read

Ingenol mebutate for mycosis fungoides.

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Ingenol mebutate is a macrocyclic diterpene ester, naturally found in the sap of the Australian plant Euphorbia peplus, which proved efficacious for actinic keratosis. In clinical routine, we observed local improvement of MF upon application of ingenol mebutate in MF patients treated for coincidental actinic keratosis within direct proximity of/overlapping with MF skin lesions. Hence, the objective of this study was to assess the effect of topical ingenol mebutate on MF skin lesions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18018
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http://dx.doi.org/10.1111/bjd.18018DOI Listing
April 2019
5 Reads

Pleomorphic mantle cell lymphoma mimicking diffuse large B cell lymphoma in peripheral blood and bone marrow.

Am J Hematol 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1002/ajh.25491DOI Listing
April 2019
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[Ga]Pentixafor PET/MR imaging of chemokine receptor 4 expression in the human carotid artery.

Eur J Nucl Med Mol Imaging 2019 Apr 19. Epub 2019 Apr 19.

Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Purpose: Type 4 chemokine receptor (CXCR4) plays an important role in immune cell migration during the atherosclerosis progression. We aimed to evaluate [Ga]Pentixafor positron emission tomography (PET) in combination magnetic resonance imaging (MRI) for in vivo quantification of CXCR4 expression in carotid plaques.

Methods: Seventy-two patients with lymphoma were prospectively scheduled for whole body [Ga]Pentixafor PET/MRI with an additional T2-weighted carotid sequence. Read More

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http://link.springer.com/10.1007/s00259-019-04322-7
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http://dx.doi.org/10.1007/s00259-019-04322-7DOI Listing
April 2019
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Serum GM3(d18:1-16:0) and GM3(d18:1-24:1) levels may be associated with lymphoma: An exploratory study with haematological diseases.

Sci Rep 2019 Apr 19;9(1):6308. Epub 2019 Apr 19.

Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.

GM3 (monosialodihexosylganglioside) is a type of ganglioside, which is a molecule composed of ceramide and oligosaccharide containing one or more sialic acids. Since GM3 is abundantly expressed in blood cells, we investigated the association between GM3 molecular species and haematological diseases. We measured the serum levels of seven GM3 molecular species in subjects with various haematological diseases (n = 52) and healthy subjects (n = 24) using a liquid chromatography tandem-mass spectrometry technique as an exploratory study. Read More

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http://dx.doi.org/10.1038/s41598-019-42817-3DOI Listing

Co-targeting of BCL2 with venetoclax and MCL1 with S63845 is synthetically lethal in relapsed mantle cell lymphoma.

Clin Cancer Res 2019 Apr 19. Epub 2019 Apr 19.

Institute of Pathological Physiology and First Dept. of Medicine- Hematology, Charles University General Hospital and First Faculty of Medicine

Purpose: Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell non-Hodgkin lymphomas characterized by (over)expression of BCL2. A BCL2-targeting drug venetoclax (VTX) has promising anticancer activity in MCL. We analyzed molecular mechanisms of VTX resistance in MCL cells, and tested strategies to overcome it. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3275DOI Listing

Abdominal Lymphoma Presenting as Terminal Ileitis: A Case Report.

J Emerg Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, Cincinnati Children's Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Background: Most pediatric patients with lymphoma do not have classic symptoms of fever, night sweats, and weight loss. Lymphoma can present as vague symptoms and may mimic common pediatric abdominal emergencies. In this case report, we present a child who presented with abdominal pain and who was initially misdiagnosed as having a surgical emergency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679193013
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http://dx.doi.org/10.1016/j.jemermed.2019.03.004DOI Listing
April 2019
2 Reads

Prenylated Rab acceptor RABAC1 inhibits anti-apoptotic protein BCL2A1 and induces apoptosis.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

The B cell lymphoma 2 (BCL2) family of proteins constitutes a critical intracellular checkpoint in the intrinsic apoptosis pathway. Among BCL2 members, the anti-apoptotic protein BCL2A1 mediates the resistance to BCL2 inhibitors and may be considered as a target for anti-cancer therapy. Here, we report that prenylated Rab acceptor 1 (RABAC1 or PRA1) inhibits the anti-apoptotic activity of BCL2A1 and induces apoptosis in AGS gastric cancer cells. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.080DOI Listing

Pixantrone, etoposide, bendamustine, rituximab (P[R]EBEN) as an effective salvage regimen for relapsed/refractory aggressive non-Hodgkin lymphoma-Polish Lymphoma Research Group real-life analysis.

Pharmacol Rep 2019 Feb 6;71(3):473-477. Epub 2019 Feb 6.

Department of Hematology, Jagiellonian University, Kraków, Poland.

Background: Despite a significant improvement in treatment outcomes, 30-40% of aggressive non-Hodgkin lymphomas (NHL) patients are refractory or relapse after the first line therapy. Half of them are not eligible to autologous stem cell transplantation (ASCT) due to failure of platinum-based salvage regimens. Pixantrone is conditionally approved in Europe in patients with R/R aggressive NHL failing at least 2 previous lines of therapy. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.001DOI Listing
February 2019

Cisplatin: The first metal based anticancer drug.

Authors:
Sumit Ghosh

Bioorg Chem 2019 Apr 11;88:102925. Epub 2019 Apr 11.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India. Electronic address:

Cisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways which finally lead to apoptosis. However, side effects and drug resistance are the two inherent challenges of cisplatin which limit its application and effectiveness. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.102925DOI Listing
April 2019
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CD30 Aptamer-functionalized PEG-PLGA nanoparticles for the superior delivery of doxorubicin to anaplastic large cell lymphoma cells.

Int J Pharm 2019 Apr 16. Epub 2019 Apr 16.

School of Biological Science and Engineering, South China University of Technology, Guangzhou 510640, China; Wenzhou Institute of Biomaterials and Engineering, CNITECH, Chinese Academy of Sciences, Wenzhou, Zhejiang Province, 325001, PR China. Electronic address:

Nanoparticles (NPs) conjugated with aptamers have been extensively in recent years, which can efficiently target cancer cells that improve the therapeutic effect. Aptamers (Apt) are small oligonucleotide molecule ligands have specific high-affinity. In this work, we developed a PEG-PLGA nanoparticles (NPs) encapsulated with doxorubicin. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.013DOI Listing

JAK3/STAT3 oncogenic pathway and PRDM1 expression stratify clinicopathologic features of extranodal NK/T‑cell lymphoma, nasal type.

Oncol Rep 2019 Apr 12. Epub 2019 Apr 12.

Department of Pathology, Peking University First Hospital, Beijing 100034, P.R. China.

The inactivation of tumor suppressor gene positive regulatory domain containing I (PRDM1) and activation of signal transducer and activator of transcription 3 (STAT3) have been detected in the majority of extranodal NK/T‑cell lymphoma, nasal type (EN‑NK/T‑NT) cases. In the present study, their association with and effects on the clinicopathologic features of EN‑NK/T‑NT are described. PRDM1 was revealed to be expressed in 19 out of 58 patients (32. Read More

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http://www.spandidos-publications.com/10.3892/or.2019.7112
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http://dx.doi.org/10.3892/or.2019.7112DOI Listing
April 2019
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Association of Occupational Pesticide Exposure With Immunochemotherapy Response and Survival Among Patients With Diffuse Large B-Cell Lymphoma.

JAMA Netw Open 2019 Apr 5;2(4):e192093. Epub 2019 Apr 5.

Department of Biostatistics, Clinical Epidemiology, Public Health, and Innovation in Methodology, Nîmes University Hospital, University of Montpellier, Montpellier, France.

Importance: Professional use of pesticides is a risk factor for non-Hodgkin lymphoma. The main biological mechanisms of pesticides and chemotherapy are genotoxicity and reactive oxygen species generation. Cellular adaptation among patients exposed to low doses of genotoxic and oxidative compounds might hinder chemotherapy efficiency in patients with lymphoma. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2093DOI Listing

Investigating the potential benefit of second biopsy of residual mass in pediatric mature B cell non-Hodgkin lymphoma.

Pediatr Hematol Oncol 2019 Apr 19:1-9. Epub 2019 Apr 19.

a Department of Hematology/Oncology , Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine , Shanghai , China.

Objectives: To assess the impact of second-look biopsy of residual mass during or after chemotherapy in pediatric mature B-cell NHL.

Methods: Patients with mature B-cell non-Hodgkin lymphoma (NHL) who were suspicious of radiological residual mass at mid or end of treatment and subjected to second biopsy were treated at our center between January 2001 and December 2015. Their clinical characteristics, imaging findings, pathological changes, management, and prognosis were reviewed retrospectively. Read More

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https://www.tandfonline.com/doi/full/10.1080/08880018.2019.1
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http://dx.doi.org/10.1080/08880018.2019.1597231DOI Listing
April 2019
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Effect of IL-6-mediated STAT3 signaling pathway on myocardial apoptosis in mice with dilated cardiomyopathy.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3042-3050

Department of Geriatrics, Quanzhou First Hospital of Fujian Medical University, Quanzhou, China.

Objective: To investigate the effect of interleukin-6 (IL-6) gene knockout on apoptosis of myocardial cells in mice with Coxsackievirus B3 (CVB3)-induced dilated cardiomyopathy (DCM) and its potential mechanism, so as to provide certain references for the clinical prevention and treatment of DCM.

Materials And Methods: A total of 40 male C57 mice were randomly divided into Sham group (n=20) and DCM group (n=20) using a random number table. Another 20 mice with IL-6 gene knockout were enrolled into DCM+IL-6 KO group (n=20). Read More

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http://www.europeanreview.org/article/17586
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http://dx.doi.org/10.26355/eurrev_201904_17586DOI Listing
April 2019
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Influence of miR-34a on myocardial apoptosis in rats with acute myocardial infarction through the ERK1/2 pathway.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3034-3041

Department of Cardiovascular Medicine, Linyi No. 3 People's Hospital, Linyi, China.

Objective: To study the influence of micro-ribonucleic acid (miR)-34a on myocardial apoptosis in rats with acute myocardial infarction (AMI) through the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway.

Materials And Methods: A total of 24 Sprague-Dawley (SD) rats were randomly divided into sham group (n=12) and model group (n=12). The heart was exposed in the sham group, while the AMI model was established in the model group. Read More

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http://www.europeanreview.org/article/17585
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http://dx.doi.org/10.26355/eurrev_201904_17585DOI Listing
April 2019
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Pre-diagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore.

Int J Cancer 2019 Apr 19. Epub 2019 Apr 19.

Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Rockville, MD, USA.

Specific organochlorines (OCs) have been associated with non-Hodgkin lymphoma (NHL) with varying degrees of evidence. These associations have not been evaluated in Asia, where the high exposure and historical environmental contamination of certain OC pesticides (e.g. Read More

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http://dx.doi.org/10.1002/ijc.32350DOI Listing

Improved prognosis of extranodal NK/T cell lymphoma, nasal type of nasal origin but not extranasal origin.

Ann Hematol 2019 Apr 19. Epub 2019 Apr 19.

Department of Hematology and Oncology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Extranodal NK/T cell lymphoma (NKTCL), nasal type (ENKL) that shows no apparent nasal involvement, is termed extranasal NKTCL or non-nasal NKTCL. In this study, we aimed to explore therapeutic approaches and outcomes in patients with extranasal NKTCL in current clinical practice. A data set of patients with newly diagnosed NKTCL who were diagnosed at 31 institutes in Japan between 2000 and 2013 was used for analysis. Read More

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http://dx.doi.org/10.1007/s00277-019-03689-9DOI Listing
April 2019
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Meningeal enhancement depicted by magnetic resonance imaging in tumor patients: neoplastic meningitis or therapy-related enhancement?

Neuroradiology 2019 Apr 18. Epub 2019 Apr 18.

Diagnostic and Interventional Neuroradiology, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

Purpose: To assess the prevalence of false-positive meningeal contrast enhancement in patients with solid tumors who were undergoing chemotherapy.

Methods: A total of 2572 magnetic resonance imaging (MRI) examinations of the brain were retrospectively evaluated by two readers for the presence of pathological meningeal contrast enhancement conspicuous for neoplastic meningitis. These patients either had malignant melanoma, breast or lung cancer, or lymphoma. Read More

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http://link.springer.com/10.1007/s00234-019-02215-y
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http://dx.doi.org/10.1007/s00234-019-02215-yDOI Listing
April 2019
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Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells.

J Immunol Res 2019 14;2019:9678098. Epub 2019 Mar 14.

Subdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), México City, Mexico.

Valproic acid (VPA) is widely recognized for its use in the control of epilepsy and other neurological disorders in the past 50 years. Recent evidence has shown the potential of VPA in the control of certain cancers, owed in part to its role in modulating epigenetic changes through the inhibition of histone deacetylases, affecting the expression of genes involved in the cell cycle, differentiation, and apoptosis. The direct impact of VPA in cells of the immune system has only been explored recently. Read More

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https://www.hindawi.com/journals/jir/2019/9678098/
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http://dx.doi.org/10.1155/2019/9678098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437734PMC
March 2019
1 Read

Development of a Transplantable GFP+ B-Cell Lymphoma Tumor Cell Line From MHC-Defined Miniature Swine: Potential for a Large Animal Tumor Model.

Front Oncol 2019 2;9:209. Epub 2019 Apr 2.

Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, United States.

The lack of a reliable and reproducible large animal tumor model for the study of hemolymphatic malignancies limits the ability to explore the underlying pathophysiology and testing of novel therapies. The goal of this study was to develop an aggressive, trackable swine tumor cell line in mice for adoptive transfer into MHC matched swine. Two tumor cell lines, post-transplant lymphoproliferative disease (PTLD) 13271 and chronic myelogenous leukemia (CML) 14736, were previously established from the Massachusetts General Hospital (MGH) miniature swine herd. Read More

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http://dx.doi.org/10.3389/fonc.2019.00209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454861PMC

BayesPI-BAR2: A New Python Package for Predicting Functional Non-coding Mutations in Cancer Patient Cohorts.

Front Genet 2019 2;10:282. Epub 2019 Apr 2.

Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Most of somatic mutations in cancer occur outside of gene coding regions. These mutations may disrupt the gene regulation by affecting protein-DNA interaction. A study of these disruptions is important in understanding tumorigenesis. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2019.00282
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http://dx.doi.org/10.3389/fgene.2019.00282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454009PMC
April 2019
1 Read

Multimodality imaging features of primary breast lymphoma - A rare entity.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):85-88

Department of Pathology, Command Hospital, Kolkata, West Bengal, India.

Primary lymphoma of breast is very rare which has no tell-tale imaging characteristics. Multimodality imaging helps not only in suggesting the possibility of lymphoma but also in its management. We present here one such case which was extensively worked up with various imaging modalities and was histologically proven as primary breast lymphoma. Read More

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http://www.ijri.org/text.asp?2019/29/1/85/255227
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http://dx.doi.org/10.4103/ijri.IJRI_344_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467037PMC
April 2019
1 Read

Primary bilateral non-Hodgkin's lymphoma of the adrenal gland.

Indian J Urol 2019 Apr-Jun;35(2):173-174

Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.

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http://dx.doi.org/10.4103/iju.IJU_359_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458806PMC

Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses.

Proc Natl Acad Sci U S A 2019 Apr 18. Epub 2019 Apr 18.

Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;

The IRF and Ets families of transcription factors regulate the expression of a range of genes involved in immune cell development and function. However, the understanding of the molecular mechanisms of each family member has been limited due to their redundancy and broad effects on multiple lineages of cells. Here, we report that double deletion of floxed and (encoding PU. Read More

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http://dx.doi.org/10.1073/pnas.1901258116DOI Listing

MDM4 is targeted by 1q gain and drives disease in Burkitt lymphoma.

Cancer Res 2019 Apr 18. Epub 2019 Apr 18.

University Hospital and University of Zurich

Oncogenic MYC activation promotes proliferation in Burkitt lymphoma (BL), but also induces cell cycle arrest and apoptosis mediated by p53, a tumor suppressor that is mutated in 40% of BL cases. To identify molecular dependencies in BL, we performed RNAi-based, loss-of-function screening in eight BL cell lines and integrated non-BL RNAi screens and genetic data. We identified 76 genes essential to BL, including genes associated with hematopoietic cell differentiation (FLI1, BCL11A) or B cell development and activation (PAX5, CDKN1B, JAK2, CARD11) and found a number of context-specific dependencies including oncogene addiction in cell lines with TCF3/ID3 or MYD88 mutation. Read More

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-3438DOI Listing
April 2019
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Correlations Between Imaging Biomarkers and Proliferation Index Ki-67 in Lymphomas: A Systematic Review and Meta-Analysis.

Clin Lymphoma Myeloma Leuk 2019 Mar 11. Epub 2019 Mar 11.

Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.

Background: Few studies investigated relationships between positron emission tomography (PET) as well as diffusion-weighted imaging (DWI) with proliferating index Ki-67 in lymphomas. The aim of the present analysis was to review the published results and perform a meta-analysis to provide data on the associations between standardized uptake values (SUV) derived from PET as well as apparent diffusion coefficient (ADC) derived from DWI with Ki-67 index in lymphomas.

Materials And Methods: The MEDLINE library was screened for relationships between PET and DWI with Ki-67 in lymphoma up to October 2018. Read More

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http://dx.doi.org/10.1016/j.clml.2019.03.005DOI Listing

Assessment of epigenetic mechanisms and DNA double-strand break repair using laser micro-irradiation technique developed for hematological cells.

EBioMedicine 2019 Apr 15. Epub 2019 Apr 15.

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA; Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address:

Background: Certain tumors rely heavily on their DNA repair capability to survive the DNA damage induced by chemotherapeutic agents. Therefore, it is important to monitor the dynamics of DNA repair in patient samples during the course of their treatment, in order to determine whether a particular drug regimen perturbs the DNA repair networks in cancer cells and provides therapeutic benefits. Quantitative measurement of proteins and/or their posttranslational modification(s) at DNA double strand breaks (DSBs) induced by laser microirradiation provides an applicable diagnostic approach to examine DNA repair and its dynamics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193022
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http://dx.doi.org/10.1016/j.ebiom.2019.03.083DOI Listing
April 2019
1 Read

Bowenoid papulosis unveiling a rare cause of immunosuppression.

Int J STD AIDS 2019 Apr 4;30(5):522-525. Epub 2019 Feb 4.

Department of Dermatology & Venereology, Govt. Medical College, Thrissur, Kerala.

Bowenoid papulosis (BP) is a premalignant condition usually caused by oncogenic types of human papillomavirus (HPV) presenting clinically as warty genital papules. Adult T-cell leukaemia-lymphoma (ATLL) is a peripheral T-cell leukaemia-lymphoma caused by the retrovirus, human T-cell lymphotropic virus 1 (HTLV-1). We report a case of BP initially mistaken as genital warts; on detailed evaluation the patient had features of chronic immunosuppression. Read More

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http://dx.doi.org/10.1177/0956462418813057DOI Listing
April 2019
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Analysis of preventability of malignancy related maternal death from the nationwide registration syste19m of maternal deaths in Japan.

J Matern Fetal Neonatal Med 2019 Apr 18:1-191. Epub 2019 Apr 18.

b Department of Obstetrics and Gynecology , Mie University School of Medicine , Mie , Japan.

Objective: We reviewed malignancy related maternal deaths in Japan to ascertain if there were avoidable factors.

Methods: Malignancy related maternal death in Japan reported to the Maternal Death Exploratory Committee, from 2010 to 2016 inclusive.

Results: There were 12 cases of maternal death caused by malignancy. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609930DOI Listing

Novel Insights of Lymphomagenesis of -Dependent Gastric Mucosa-Associated Lymphoid Tissue Lymphoma.

Cancers (Basel) 2019 Apr 17;11(4). Epub 2019 Apr 17.

Cancer Research Center, National Taiwan University College of Medicine, Taipei 100, Taiwan.

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is the most common subtype of gastric lymphoma. Most gastric MALT lymphomas are characterized by their association with the (HP) infection and are cured by first-line HP eradication therapy (HPE). Several studies have been conducted to investigate why most gastric MALT lymphomas remain localized, are dependent on HP infection, and show HP-specific intratumoral T-cells (e. Read More

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http://dx.doi.org/10.3390/cancers11040547DOI Listing

Discovery of 7H-pyrrolo[2,3-d]pyrimidine derivatives as selective covalent irreversible inhibitors of interleukin-2-inducible T-cell kinase (Itk).

Eur J Med Chem 2019 Mar 26;173:167-183. Epub 2019 Mar 26.

State Key Laboratory of Chemical Oncogenomics, Engineering Laboratory for Chiral Drug Synthesis, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, 518055, China. Electronic address:

Interleukin-2-inducible T-cell kinase (Itk) plays an important role in multiple signal transduction pathways in T and mast cells, and is a potential drug target for treating inflammatory diseases, autoimmune diseases, and T cell leukemia/lymphoma. Herein, we describe the discovery of a series of covalent Itk inhibitors based on the 7H-pyrrolo[2,3-d]pyrimidine scaffold. Placing an appropriate substitution group at a hydration site of the ATP binding pocket of Itk and using a saturated heterocyclic ring as a linker to the reactive group were crucial for selectivity. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.055DOI Listing

Belizatinib: Novel reactive intermediates and bioactivation pathways characterized by LC-MS/MS.

J Pharm Biomed Anal 2019 Apr 6;171:132-147. Epub 2019 Apr 6.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt. Electronic address:

Belizatinib (BZB; TSR-011) is a next-generation anaplastic lymphoma kinase inhibitor that also inhibits tropomyosin-related kinases A/B/C. In this in-vitro study, we examined the formation of reactive metabolites from BZB using rat liver microsomes or human liver microsomes in the presence of a trapping agent (potassium cyanide) to generate iminium reactive intermediates. Identification of the in vitro BZB metabolites indicated that the major in-vitro metabolic reaction involved hydroxylation of the piperidine moiety. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07317085193001
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http://dx.doi.org/10.1016/j.jpba.2019.04.006DOI Listing
April 2019
2 Reads

Intravascular large B-cell lymphoma with initial presentation in skin: a rare mimicker of cellulitis.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.03.035DOI Listing

"A Prospective Approach to Inform and Treat 1,340 Patients at Risk for BIA-ALCL."

Plast Reconstr Surg 2019 Apr 9. Epub 2019 Apr 9.

Background: Breast implant-associated anaplastic large cell lymphoma's increasing incidence and associated mortality has become alarming. However, many patients remain unaware of their risk for BIA-ALCL and may overlook early warning signs of the cancer. The authors aim to contact all breast implant patients at a single institution to educate them on the disease and provide screening and treatment as indicated. Read More

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http://Insights.ovid.com/crossref?an=00006534-900000000-9756
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http://dx.doi.org/10.1097/PRS.0000000000005703DOI Listing
April 2019
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Presumed Choroidal Granuloma Annulare Mimicking Choroidal Lymphoma.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e128-e132

A 71-year-old white male presented with unilateral trace vitreous cell and hypopigmented choroidal lesions, corresponding to hyporeflective areas on optical coherence tomography (OCT). The lesions grew slowly during a period of 2.5 years, but the patient remained asymptomatic. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2019
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http://dx.doi.org/10.3928/23258160-20190401-18DOI Listing
April 2019
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Staging of primary cutaneous follicle centre B-cell lymphoma: bone marrow biopsy, CD10, BCL2 and t(14;18) are not relevant prognostic factors.

Eur J Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Dermatologie, Institut Universitaire du Cancer de Toulouse, Université Paul Sabatier, Hôpital Larrey et Oncopole, Toulouse.

Background: There is a certain degree of controversy as to whether bone marrow biopsy is required during the staging procedures for primary cutaneous follicle centre B-cell lymphoma (PCFCCL).

Objectives: Firstly, to determine extra-cutaneous involvement at initial diagnosis, in particular, based on bone marrow biopsy, and secondly, evaluate the phenotypic features associated with extra-cutaneous involvement during follow-up (in particular, the predictive value of BCL2 and CD10 coexpression and identification of t[14;18] in skin lesions, as well as bone marrow biopsy involvement at initial staging) in a cohort of patients with PCFCCL.

Materials & Methods: A bicentric retrospective study was established to investigate 75 cases of PCFCCL, for which 44 bone marrow biopsies were performed. Read More

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http://dx.doi.org/10.1684/ejd.2018.3489DOI Listing
April 2019
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[Value of MYC, BCL-2 and BCL-6 for Evaluation of Prognosis in Patients with Diffuse Large B Cell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):452-457

Department of Hematology, Hainan Provincial People's Hospital, Haikou 571100, Hainan Province, China.

Objective: To analyze the prognostic value of BCL-2, BCL-6 and MYC in patients with diffuse large B cell lymphoma (DLBCL).

Methods: One hundred and sixty three cases of DLBCL in our hospital from March 2012 to March 2015 were selected. The specimens of lymphoma tissue of patients were collected. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.023DOI Listing

[Expression of MiR-155 in Tissue of Patients with Diffuse Large B-Cell Lymphoma and Its Effect on Cell Biological Characteristics].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):445-451

Department of Hemotology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province ,

Objective: To investigate the expression of miR-155 in patients with diffuse large B-cell lymphoma (DLBCL), and to explore the effect of transfection of miR-155 inhibitor on the biological characteristics of DLBCL cells.

Methods: A total of 76 patients with DLBCL treated in our hospital were selected from April 2013 to December 2017. In the same time, 40 cases of lymph node reactive hyperplasia (LNRH) were selected as control group. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.022DOI Listing

[Exploration of the Role of Tumor Suppressor Genes Foxo1 and PTEN in the Tumorigenesis of Mouse Natural Killer-Cell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):439-444

Clinical College of 307 Hospital, PLA, Anhui Medical University; Hefei 230032, Anhui Province, China,Department of Lymphoma, General Hospital of PLA Fifth Medical Center, Beijing 100071,

Objective: To explore whether tumor suppressor gene Foxo1 and PTEN play a critical role in the tumorigenesis of mouse natural killer-cell lymphoma.

Methods: NKp46-iCre mice were crossed with mice carrying floxed Foxo1 alleles (Foxo1) as well as floxed PTEN alleles (PTEN) to generate mice in which Foxo1 and PTEN in NK cells were knock-out, referred as Foxo1PTEN. The growth and development of the mice and tumor formation were observed. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.021DOI Listing
April 2019
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[Silencing Calreticulin Expression Inhibits Invasion Ability of SNK6 Cells in Vitro via Down-Regulating Expression of VEGF and MMP2/9].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):433-438

Department of Hematology, The Quanzhou First Hospital Affilited to Fujian Medical University, Quanzhou 362000, Fujian Province, China.

Objective: To investigate the effect of steadily down-regulating the expression of calreticulin (CALR) on the invasion of natural killer/T-cell lymphoma SNK6 cells, and explore its possible mechanism.

Methods: The sequences of specific short hairpin RNA (shRNA) targeting on human CALR were designed, and were inserted into pLKO.1-puro lentivirus vector, and the reconbinant lentivirus vector was obtained; the lentivirus particles were backed by three-plasmid system and transfected into SNK6 cells, the SNK6 cells stably down-regulating the CALR expression were sercened by puromytain, the CALR-silencing effect was verified by real-time PCR and Western blot. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.020DOI Listing

[Clinical Analysis of 37 Patients with Primary Tonsil Diffuse Large B Cell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):426-432

Department of Hematology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People's Hospital) , Nanjing 210029, Jiangsu province, China,E-mail:

Objective: To investigate the clinical manifestation, immunophenotypes and prognostic factors of patients with primary tonsil afftive large B cell lymphoma ( PT-DLBCL ).

Methods: The clinical data including clinical characterstics, typing, staging, treatment efficacy and prognostic factors of PT-DLBCL patients were collected and analyzed restrospectively.

Results: Out of 36 cases with the detinite cell origin, 24 cases (66. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.019DOI Listing

[Clinical role of Morphology in Diagnosing Bone Marrow Involvement of Diffuse Large B Bell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):421-425

Department of Hematology, Peking Union Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China,E-mail:

Objective: To determine the significance of morphology of bone marrow smear for diagnosis of bone marrow involvement in patients with diffuse large B-cell lymphoma (DLBCL), and to study the morphological characteristics of DLBCL cells involved in bone marrow.

Methods: Four hundred and twenty cases of DLBCL diagnosed at Peking Union Hospital from 2006 to 2016 were analyzed and identified.

Results: Blinded analysis of bone marrow smear and bone marrow biopsy data showed involvement in 42 cases on smears (S), in 47cases by biopsy (B) and the in 49 cases by (S+B). Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.018DOI Listing

Clinical value of molecular MRD monitoring by next-generation sequencing in patients with IDH2 mutated AML.

Leuk Lymphoma 2019 Apr 18:1-3. Epub 2019 Apr 18.

c University Department of Hematology and Central Hematology Laboratory , Inselspital, Bern University Hospital , Bern , Switzerland.

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http://dx.doi.org/10.1080/10428194.2019.1585838DOI Listing

The impact of JAK/STAT inhibitor ruxolitinib on the genesis of lymphoproliferative diseases

Turk J Med Sci 2019 Apr 18;49(2):661-674. Epub 2019 Apr 18.

Background/aim: Ruxolitinib, a JAK/STAT signaling pathway inhibitor targeted drug, has been approved for the controlling of disease symptoms and splenomegaly in patients with myeloproliferative neoplastic diseases. Recently, it has been proposed that ruxolitinib-induced JAK/STAT pathway inhibition in myelofibrosis is associated with an elevated frequency of aggressive B-cell lymphomas. However, the biological basis and significance of this pharmacobiological adverse event is unknown. Read More

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http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=s
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http://dx.doi.org/10.3906/sag-1807-152DOI Listing
April 2019
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Long-term results with the adapted LMB 96 protocol in children with B-cell non Hodgkin lymphoma treated in Iraq: comparison in two subsequent cohorts of patients.

Leuk Lymphoma 2019 May;60(5):1224-1233

b College of Medicine-Iraq, Department of Pediatrics , Children's Welfare Teaching Hospital-Baghdad , Baghdad , Iraq.

Since 2000, an adapted LMB 96 protocol was implemented at the Children-Welfare-Teaching-Hospital in Baghdad for the treatment of childhood B-cell non-Hodgkin lymphoma. The first experience (2000-2005) demonstrated efficacy and feasibility of this protocol in Iraq. In 2006, further adjustments were made in an attempt to reduce therapy-related toxicities. Read More

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https://www.tandfonline.com/doi/full/10.1080/10428194.2018.1
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http://dx.doi.org/10.1080/10428194.2018.1519810DOI Listing
May 2019
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