299,273 results match your criteria Lymphomas Endocrine Mesenchymal and Other Rare Tumors of the Mediastinum

Introducing innovative cellular therapies into the clinic: a 2-year retrospective experience of a chimeric antigen receptor T-cell programme at a single centre in Switzerland.

Swiss Med Wkly 2022 Jun 20;152:w30186. Epub 2022 Jun 20.

Department of Medical Oncology and Haematology, University Hospital Zurich, Switzerland.

Aim Of The Study: Chimeric antigen receptor T (CAR-T) cells are a powerful form of immune-cell therapy for patients with relapsed/refractory B-cell lymphoma and acute B lymphoblastic leukaemia. CAR-T cells have been commercially available in Switzerland since 2018. Because of the complexity and costs of this treatment it is critical to review patient outcomes in real-world settings, to examine whether the promising results from pivotal trials can be reproduced and to identify clinical parameters that determine their efficacy. Read More

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CD30 + Primary intestinal T-cell lymphoma (unclassified) masquerading as chronic inflammation: a case report.

Diagn Pathol 2022 Jun 25;17(1):53. Epub 2022 Jun 25.

Department of Pathology, University of Illinois at Chicago, 840 S. Wood Street, 260 CMET, Chicago, USA.

Background: Primary intestinal T-cell lymphomas are uncommon malignancies that pose a diagnostic dilemma, because the clinical features and imaging findings commonly overlap with those encountered in inflammatory bowel diseases.

Case Presentation: The current clinical case report describes the clinical history, laboratory findings and histopathological analysis from a patient with non-specific gastrointestinal symptoms with a presumptive clinical diagnosis of inflammatory bowel disease, and two intestinal biopsy specimens with non-specific findings. Due to the persistent symptoms a third biopsy was consistent with primary intestinal T-cell lymphoma, a diagnosis that was elusive for months after the initial presentation. Read More

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Evaluation of the putative lymphoma-associated point mutation D427H in the STAT3 transcription factor.

BMC Mol Cell Biol 2022 Jun 25;23(1):23. Epub 2022 Jun 25.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Centre Göttingen, 37073, Göttingen, Germany.

Background: Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor that promotes cell proliferation and immunomodulation in untransformed cells and maintains stemness of transformed cells, facilitating invasion and metastasis. Numerous point mutations in the STAT3 protein have been identified that drive malignancy in various tumor entities. The missense mutation D427H localized in the STAT3 DNA-binding domain has been previously reported in patients with NK/T cell lymphomas. Read More

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Concomitant hepatocellular carcinoma recurrence and mantle cell lymphoma.

Hepatobiliary Pancreat Dis Int 2022 Jun 16. Epub 2022 Jun 16.

Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. Electronic address:

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Apoptotic and autophagic death union by Thuja occidentalis homeopathic drug in cervical cancer cells with thujone as the bioactive principle.

J Integr Med 2022 Jun 15. Epub 2022 Jun 15.

Department of Botany, University of Calcutta, Kolkata, West Bengal 700019, India. Electronic address:

Objective: "Multi-targeting" drugs can prove fruitful to combat drug-resistance of multifactorial disease-cervical cancer. This study envisioned to reveal if Thuja homeopathic mother tincture (MT) and its bioactive component could combat human papillomavirus (HPV)-16-infected SiHa cervical cancer cells since it is globally acclaimed for HPV-mediated warts.

Methods: Thuja MT was studied for its antiproliferative and antimigratory properties in SiHa cells followed by microscopic determination of reactive oxygen species (ROS) generation by 2',7'-dichlorodihydrofluorescein diacetate (DCFDA) staining and loss in mitochondrial membrane potential (MtMP) by rhodamine 123 (Rh123) staining. Read More

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Cardiopulmonary predictors of mortality in patients with COVID-19: What are the findings?

Arch Cardiovasc Dis 2022 Jun 8. Epub 2022 Jun 8.

Advanced Thoracic Research Centre, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Since 2019, coronavirus disease 2019 (COVID-19) has been the leading cause of mortality worldwide.

Aims: To determine independent predictors of mortality in COVID-19, and identify any associations between pulmonary disease severity and cardiac involvement.

Methods: Clinical, laboratory, electrocardiography and computed tomography (CT) imaging data were collected from 389 consecutive patients with COVID-19. Read More

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FNA 2.0: Value of cytopathologist-performed ultrasound-guided core-needle biopsy.

David Lieu

Semin Diagn Pathol 2022 Jun 13. Epub 2022 Jun 13.

University of California, Los Angeles/Fine Needle Aspiration Medical Group, 320 S. Garfield Ave. # 278, Alhambra, CA 91801 United States. Electronic address:

In the late 20 century, pathologist-performed palpation-guided fine-needle aspiration (PG-FNA) of superficial masses was popularized in the United States. It brought pathologists out of the laboratory to see patients and the hope of decreasing the need for surgical biopsy for diagnostic purposes. This first iteration of minimally invasive tissue sampling could be informally called FNA 1. Read More

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Progression-Free Survival at 24 Months as A Landmark After Autologous Stem Cell Transplant in Relapsed or Refractory Diffuse Large B-cell Lymphoma.

Transplant Cell Ther 2022 Jun 22. Epub 2022 Jun 22.

Division of Hematology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) who achieve progression-free survival (PFS) at 24 months (PFS24) following immunochemotherapy (IC) have excellent overall survival (OS) comparable to that of the age- and sex-matched general population. However, a similar landmark has not been established for patients with relapsed or refractory (RR) DLBCL following frontline IC who are subsequently treated with salvage therapy followed by autologous stem cell transplant (ASCT).

Objective: To evaluate the role of PFS24 as a landmark after ASCT in patients with RR DLBCL. Read More

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Dural Marginal Zone Lymphoma With Extensive Crystal Storing Histiocytosis: Spotting the Zebra Among the Horses.

J Neuropathol Exp Neurol 2022 Jun 25. Epub 2022 Jun 25.

Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

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Primary Breast Lymphoma Mimicking Metastatic Breast Cancer on 18F-FDG PET-CT.

J Pak Med Assoc 2022 Jun;72(6):1241-1242

Department of Hematology, Kuwait Cancer Control Center, Kuwait.

18F-Fluorodeoxyglucose (FDG) PET-CT is an excellent imaging modality for the evaluation of non-Hodgkin lymphoma (NHL). We report a case of a 45-year-old woman presented with a large right breast mass and suspicious right axillary lymph nodes referred for 18F-FDG PET-CT for staging. 18F-FDG PET-CT images show large hypermetabolic right breast mass infiltrating the skin, multiple hypermetabolic right axillary and subpectoral lymph nodes, along with multiple hypermetabolic bone lesions at axial and appendicular skeleton. Read More

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Ocular recurrence of primary central nervous system diffuse large B-cell lymphoma: A case report.

Asian J Surg 2022 Jun 21. Epub 2022 Jun 21.

Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, PR China. Electronic address:

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Prognostic Impact of Adiposity in Hematological Malignancies: A Systematic Review and Meta-analysis.

Clin Lymphoma Myeloma Leuk 2022 May 29. Epub 2022 May 29.

Sarah Cannon - Nashville TN.

It has been proposed that direct measurement of adiposity has a greater accuracy as a prognostic factor in various malignancies than anthropometric measures such as BMI. We evaluated the association of visceral and subcutaneous adiposity with outcomes in patients with hematological malignancies with a systematic review and meta-analysis. This systematic review included patients with hematological malignancies who had the analysis of overall mortality and progression-free survival according to their adiposity status. Read More

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Nivolumab in patients with relapsed or refractory peripheral T-cell lymphoma: modest activity and cases of hyperprogression.

J Immunother Cancer 2022 Jun;10(6)

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Peripheral T-cell lymphomas (PTCL), a heterogeneous group of mature aggressive non-Hodgkin's lymphomas, carry a worse prognosis for most subtypes when compared with their B-cell counterparts. Despite recent approval of newer therapies, the outlook for patients with relapsed/refractory (RR) PTCL remains poor and new treatment strategies are clearly needed. Targeting the profoundly immunosuppressive tumor microenvironment in PTCL is one such approach. Read More

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BCL10 loss-of-function novel mutation leading to atypical severe combined immunodeficiency.

Clin Immunol 2022 Jun 21:109067. Epub 2022 Jun 21.

Department of Clinical Genetics, Sultan Qaboos University Hospital, Muscat, Oman; Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.

Background: Severe combined immunodeficiency (SCID) is characterized by severe, early-onset infection in infants. B-cell lymphoma/leukemia (BCL) 10 defects causing SCID have been reported previously in two patients.

Material & Methods: A seven-month-old female infant was admitted with bilateral pneumonia requiring ventilatory support. Read More

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Environmental co-exposure of high temperature and Cu induce hormonal disturbance of cortisol signaling and altered responses of cellular defense genes in zebrafish.

Sci Total Environ 2022 Jun 21:156555. Epub 2022 Jun 21.

Fisheries Science Institute, Chonnam National University, Yeosu 59626, South Korea; Department of Ocean Integrated Science, Chonnam National University, Yeosu 59626, South Korea. Electronic address:

Global warming is causing a continuous increase in environmental temperatures, which simultaneously activates toxic environmental stresses, such as heavy metal exposure, in aquatic ecosystems. The present study aimed at evaluating the effects of Cu toxicity along with increased temperature during zebrafish embryogenesis. Decreased survival rates were observed following combined exposure to high temperature and Cu. Read More

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Senescence in pulmonary arterial hypertension: is there a link?

Curr Opin Pulm Med 2022 Jul;28(4):303-306

Maastricht University Campus Venlo, Venlo.

Purpose Of Review: Cellular senescence has been recognized as a promising target in the treatment of many cardiovascular diseases. The pathways involved in the development of senescence share many similarities with pathobiological mechanisms of pulmonary arterial hypertension (PAH). But the potential of senolytics to improve pulmonary hemodynamics and to reduce vascular remodelling in PAH has thus far not been investigated in depth. Read More

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3,5,7-Substituted Pyrazolo[4,3-]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.

J Med Chem 2022 Jun 24. Epub 2022 Jun 24.

Department of Experimental Biology, Faculty of Science, Palacký University Olomouc, Šlechtitelů 27, 78371 Olomouc, Czech Republic.

3,5,7-Trisubstituted pyrazolo[4,3-]pyrimidines have been identified as potent inhibitors of cyclin-dependent kinases (CDKs), which are established drug targets. Herein, we describe their further structural modifications leading to novel nanomolar inhibitors with strong antiproliferative activity. We determined the crystal structure of fully active CDK2/A2 with 5-(2-amino-1-ethyl)thio-3-cyclobutyl-7-[4-(pyrazol-1-yl)benzyl]amino-1(2)-pyrazolo[4,3-]pyrimidine () at 1. Read More

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Improved overall survival over time in advanced stage mycosis fungoides: a cross-sectional study.

Leuk Lymphoma 2022 Jun 24:1-8. Epub 2022 Jun 24.

Department of Radiation Oncology, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT, USA.

Mycosis Fungoides (MF) is a rare T-cell lymphoma and evidence on treatment practices, and outcomes are limited. We evaluated changes in practice patterns and corresponding effects on overall survival (OS) in MF using a cross-sectional study of patients diagnosed with MF from 2004 to 2016 in the National Cancer Database. Outcomes evaluated included patterns of care and OS across treatment eras. Read More

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Outcomes after initial refusal of curative treatment in patients with classic Hodgkin lymphoma.

Leuk Lymphoma 2022 Jun 24:1-4. Epub 2022 Jun 24.

Centre for Lymphoid Cancer and Division of Medical Oncology, BC Cancer and the University of British Columbia, Vancouver, Canada.

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Pathway importance by graph convolutional network and Shapley additive explanations in gene expression phenotype of diffuse large B-cell lymphoma.

PLoS One 2022 24;17(6):e0269570. Epub 2022 Jun 24.

Department of Biomedical Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Deep learning techniques have recently been applied to analyze associations between gene expression data and disease phenotypes. However, there are concerns regarding the black box problem: it is difficult to interpret why the prediction results are obtained using deep learning models from model parameters. New methods have been proposed for interpreting deep learning model predictions but have not been applied to genetics. Read More

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Neurofibromatosis from Head to Toe: What the Radiologist Needs to Know.

Radiographics 2022 Jun 24:210235. Epub 2022 Jun 24.

From the Department of Radiology (M.X.W., C.T.J., K.M.E.) and Department of Lymphoma and Myeloma (S.K.), University of Texas MD Anderson Cancer Center, Pickens Academic Tower, 1400 Pressler St, Houston, TX 77030-4009; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio (J.R.D.); Department of Radiology, Stanford University, Stanford, Calif (J.G.); Department of Radiology (A.H.) and Faculty of Medicine (M.M.), Alexandria University, Alexandria, Egypt; and Department of Radiology, Mayo Clinic Arizona, Phoenix/Scottsdale, Ariz (P.M.P.).

Neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2) are autosomal dominant inherited neurocutaneous disorders or phakomatoses secondary to mutations in the and tumor suppressor genes, respectively. Although they share a common name, NF1 and NF2 are distinct disorders with a wide range of multisystem manifestations that include benign and malignant tumors. Imaging plays an essential role in diagnosis, surveillance, and management of individuals with NF1 and NF2. Read More

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Pegylated asparaginase in feline high-grade lymphoma: clinical results of single injection and continued incorporation into a modified COP regimen.

J Feline Med Surg 2022 Jun 24:1098612X221101533. Epub 2022 Jun 24.

Department of Clinical Sciences, Veterinary Faculty, Utrecht University, CM Utrecht, the Netherlands.

Objectives: The aim of this retrospective study was to determine the response to a single injection of pegylated asparaginase ('pegaspargase') and to assess the tolerability and outcome of prolonged incorporation of pegaspargase into a modified COP (cyclophosphamide, vincristine, prednisolone) regimen in pegaspargase sensitive cats.

Methods: Fifty-six client-owned cats with confirmed macroscopic high-grade lymphoma at any anatomical site were included. Treatment was commenced with a single pegaspargase injection. Read More

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Multi-omics analysis reveals the panoramic picture of necroptosis-related regulators in pan-cancer.

Aging (Albany NY) 2022 Jun 21;14(undefined). Epub 2022 Jun 21.

Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

Background: Unlike apoptosis, necroptosis is a tightly regulated form of programmed cell death (PCD) that occurs in a caspase-independent manner and is mainly triggered by receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 and the RIPK3 substrate mixed-lineage kinase domain-like protein (MLKL). A growing body of evidence has documented that necroptosis, as a novel therapeutic strategy to overcome apoptosis resistance, has potential pro- or anti-tumoral effects in tumorigenesis, metastasis, and immunosurveillance. However, comprehensive multi-omics studies on regulators of necroptosis from a pan-cancer perspective are lacking. Read More

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Treatments of Ph-like acute lymphoblastic leukemia: a real-world retrospective analysis from a single large center in China.

Leuk Lymphoma 2022 Jun 24:1-11. Epub 2022 Jun 24.

Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Collaborative Innovation Center of Hematology, The First Affiliated Hospital of Soochow University, Institute of Blood and Marrow Transplantation, Soochow University, Suzhou, P.R. China.

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk subtype of ALL. We retrospectively studied 70 cases with Ph-like ALL and here present the largest study of CAR-T cell treatment and haplo-HSCT for this leukemia. Median age was 26 years and median leukocyte count was 31. Read More

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Primary pancreatic lymphoma: thinking beyond pancreatic adenocarcinoma.

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Gastroenterología y Endoscopia Digestiva, Universidad Autónoma de Nuevo León, Mexico.

Primary pancreatic lymphoma is one of the rare primary pancreatic tumors with a low incidence compared to adenocarcinoma, which is the most frequent. Currently there are diagnostic tools such as percutaneous biopsy and endoscopic ultrasound to reach its diagnosis. Primary lymphoma of the pancreas has defined therapeutic targets as well as a better prognosis compared to other tumors. Read More

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Cost-effectiveness of ensartinib for patients with anaplastic lymphoma kinase-positive non-small-cell lung cancer in China.

J Comp Eff Res 2022 Jun 24. Epub 2022 Jun 24.

College of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 230000, China.

Crizotinib and ensartinib improved survival in patients with arrangement non-small-cell lung cancer (NSCLC); however, the economic outcomes of using ensartinib versus crizotinib are still unclear. The objective of this study was to assess the cost-effectiveness of ensartinib versus crizotinib for -positive NSCLC patients from the perspective of China's healthcare system. A partitioned survival model with three health states (stable, progressive and death) was developed. Read More

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Multifocal lymphadenopathies with polyclonal reactions primed after EBV infection in a mRNA-1273 vaccine recipient.

Swiss Med Wkly 2022 05 23;152:w30188. Epub 2022 May 23.

Service of Infectious Diseases, University Hospital Centre (CHUV), Lausanne, Switzerland.

We report a case of recurrent tender, multifocal lymphadenopathies associated with B-symptoms, clinically mimicking lymphoma in a mRNA-1273 vaccine recipient after a recent Epstein-Barr virus (EBV) infection. In the lymph node biopsy, monocytoid B-cell hyperplasia, TH2 (GATA3+) predominance, and hyperplasia of interferon-gamma-producing plasmacytoid dendritic cells were observed along with sustained neutralising antibody production against SARS-CoV-2 wild-type and five variants. High titres of anti-S antibodies and neutralising antibodies were observed, excepted for variant B. Read More

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Immunological differences between heart- and kidney-transplanted children: a cross-sectional study.

Cardiol Young 2022 Jun 24:1-6. Epub 2022 Jun 24.

Department of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Post-transplantation lymphoproliferative is a potentially mortal complication after heart transplantation in children. As the immune system plays a crucial role in the development of lymphoma, we explored the influence of thymus function in relation to immunosuppressive treatment in organ-transplanted children and healthy control subjects. A prospective case-control study was performed at a single centre, in which 36 children who had undergone heart transplantation were compared to two control groups: 34 kidney-transplanted children and 33 healthy age- and sex-matched children. Read More

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