273,894 results match your criteria Lymphomas Endocrine Mesenchymal and Other Rare Tumors of the Mediastinum


Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.

N Engl J Med 2020 06;382(23):2207-2219

From the Departments of Pediatric and Adolescent Oncology (V.M.-C., C.P.) and Clinical Research (G.V.), INSERM Unité 1015 (V.M.-C.), and the Unit of Biostatistics and Epidemiology and INSERM Unité 1018 (A.A.), Gustave Roussy, Université Paris-Saclay, Villejuif, France; the Department of Pediatric Hematology and Oncology, University of Padua, Padua, Italy (M.P.); the Department of Paediatric Haematology, Oncology, and Palliative Care, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge (G.A.A.B.), Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham (K.W.), and the Department of Histopathology, Royal Marsden NHS Foundation Trust, London (A.W.) - all in the United Kingdom; the Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles (D.A.B.); the Department of Pediatric Hematology and Oncology, University of Valencia, Valencia, Spain (R.F.D.); the Division of Haematology-Oncology, Hospital for Sick Children, Toronto (S.A.); the Department of Pediatric Hematology and Oncology, University Hospitals Leuven, Leuven, Belgium (A.U.); the Center for Cancer and Immunology Research, Children's National Health System and George Washington University, Washington, DC (C.M.B.); Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands (J.Z.); the Department of Pediatric Hematology and Oncology, Semmelweis University, Budapest, Hungary (M.C.); the Department of Pediatric Bone Marrow Transplantation, Oncology, and Hematology, Wroclaw Medical University, Wroclaw, Poland (B.K.); the Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong (A.K.C.); the Department of Pathology, University of Utah, Salt Lake City (R.R.M.); Children's Hospital of Philadelphia, Philadelphia (P.C.A.); and the National Cancer Institute, Center for Global Health, Rockville, MD (T.G.G.).

Background: Rituximab added to chemotherapy prolongs survival among adults with B-cell cancer. Data on its efficacy and safety in children with high-grade, mature B-cell non-Hodgkin's lymphoma are limited.

Methods: We conducted an open-label, international, randomized, phase 3 trial involving patients younger than 18 years of age with high-risk, mature B-cell non-Hodgkin's lymphoma (stage III with an elevated lactate dehydrogenase level or stage IV) or acute leukemia to compare the addition of six doses of rituximab to standard lymphomes malins B (LMB) chemotherapy with standard LMB chemotherapy alone. Read More

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http://dx.doi.org/10.1056/NEJMoa1915315DOI Listing

A case of classical Hodgkin Lymphoma-type of Richter Transformation with prolonged survival: Fine-Needle Aspiration findings and mimickers.

Cytopathology 2020 Jun 3. Epub 2020 Jun 3.

Centro Hospitalar Universitário de São João, Porto, Portugal.

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is an indolent lymphoma that has the potential to develop into a more aggressive lymphoma, known as Richter transformation (RT) . RT dramatically changes the course of CLL/SLL requiring urgent recognition and appropriate treatment. Read More

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http://dx.doi.org/10.1111/cyt.12870DOI Listing

Suppressed microRNA-195-5p expression in mycosis fungoides promotes tumor cell proliferation.

Exp Dermatol 2020 Jun 3. Epub 2020 Jun 3.

Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.

Background: Several cancers, including mycosis fungoides (MF), have reported dysregulation of miR-195-5p. miR-195-5p plays a role in cell cycle regulation in several malignant diseases.

Objectives: This study aimed to investigate: i) the expression level of miR-195-5p in lesional MF skin biopsies and II) the potential regulatory roles of miR-195-5p in MF. Read More

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http://dx.doi.org/10.1111/exd.14124DOI Listing

The role of apoptosis in the complex pathogenesis of the most common obstetrics and gynaecology diseases.

Physiol Int 2020 Mar;107(1):106-119

2Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.

Purpose: We aimed to assess the etiological role of apoptotic genes Bcl-2 and Bax in the background of major obstetric and gynaecological diseases.

Methods: Placental tissue samples were collected from 101 pregnancies with intrauterine growth restriction and 104 pregnancies with premature birth with 140 controll samples from term, eutrophic newborns. In addition, gene expression assessment of the genes Bax and Bcl-2 was performed in 101 uterine leiomyoma tissue samples at our disposal with 110 control cases. Read More

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http://dx.doi.org/10.1556/2060.2020.00014DOI Listing

Anaplastic large cell lymphoma: Report of two cases with rare patterns (carcinomatous and sarcomatous) in fine needle aspiration cytology and histopathology.

Diagn Cytopathol 2020 Jun 3. Epub 2020 Jun 3.

Faculty of Medicine, Department of Pathology, Kuwait University, Safat, Kuwait.

Anaplastic large cell lymphoma (ALCL) is a non-Hodgkin lymphoma of T-cell or null-cell lineage with variable cytomorphology. We report two rare ALCL cases with carcinomatous and sarcomatous patterns, respectively, in fine needle aspiration (FNA) cytology and histopathology. The first case was a 56-year-old man with enlarged left inguinal lymph node. Read More

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http://dx.doi.org/10.1002/dc.24477DOI Listing

Liver involvement in pediatric Hodgkin lymphoma: A systematic review by an international collaboration on Staging Evaluation and Response Criteria Harmonization (SEARCH) for Children, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL).

Pediatr Blood Cancer 2020 Jun 3:e28365. Epub 2020 Jun 3.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.

Hepatic involvement in Hodgkin lymphoma (HL) is uncommon (∼5% of patients) but always implies stage IV disease. Accurate staging is mandatory for making the appropriate risk assignment and treatment decisions. The Staging Evaluation and Response Criteria Harmonization for Childhood, Adolescent and Young Adult Hodgkin Lymphoma (SEARCH for CAYAHL) international working group conducted a systematic literature review of liver involvement in HL patients with the aim to propose a universally acceptable definition for liver involvement in pediatric HL. Read More

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http://dx.doi.org/10.1002/pbc.28365DOI Listing

Real-World Treatment Patterns and Progression-Free Survival Associated with Anaplastic Lymphoma Kinase (ALK) Tyrosine Kinase Inhibitor Therapies for ALK+ Non-Small Cell Lung Cancer.

Oncologist 2020 Jun 3. Epub 2020 Jun 3.

Florida Hospital Cancer Institute, Orlando, Florida, USA.

Background: Little is known about real-world treatment and outcomes of patients with anaplastic lymphoma kinase-positive (ALK+) advanced non-small cell lung cancer (NSCLC).

Materials And Methods: This retrospective study of the Flatiron Health EHR-derived deidentified database included patients with a lung cancer diagnosis and confirmed advanced NSCLC who received ALK tyrosine kinase inhibitor (TKI) therapy (January 1, 2011, to June 30, 2018). Patient characteristics and treatment patterns were characterized. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0011DOI Listing

Generalized granuloma annulare heralding relapse of non-Hodgkin lymphoma.

JAAD Case Rep 2020 Jun 24;6(6):534-536. Epub 2020 Apr 24.

Department of Internal Medicine, East Tennessee State University Quillen College of Medicine, Johnson City, Tennessee.

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http://dx.doi.org/10.1016/j.jdcr.2020.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256230PMC

Lymphomatoid papulosis successfully managed with excimer laser maintenance therapy.

JAAD Case Rep 2020 Jun 18;6(6):495-497. Epub 2020 Apr 18.

Department of Dermatology, University of California, San Francisco, California.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256238PMC

A rare association of bullous pemphigoid with mycosis fungoides and Sézary syndrome.

JAAD Case Rep 2020 Jun 1;6(6):486-488. Epub 2020 May 1.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256241PMC

Caspase Dependent and Independent Anti-hematological Malignancy Activity of AMHA1 Attenuated Newcastle Disease Virus.

Int J Mol Cell Med 2019 ;8(3):211-223

Experimental Therapy Department, Iraqi Center for cancer and medical genetics research, Mustansiriyah University, Baghdad, Iraq.

Hematological malignancies remain one of the leading causes of death worldwide despite advances in cancer therapeutics. Newcastle disease virus (NDV) is a member of that elicits considerable interest as an anticancer agent because it can replicate up to 10 000 times faster in human cancer cells than in most normal cancer cells. Several NDV strains reportedly induce the cytolysis of cancerous cell lines. Read More

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http://dx.doi.org/10.22088/IJMCM.BUMS.8.3.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241843PMC
January 2019

Burkitt lymphoma initially mimicking varicella zoster infection.

IDCases 2020 14;21:e00818. Epub 2020 May 14.

Hematology Unit, Medical Specialty Center, Bangkok Hospital Hat Yai, Bangkok Dusit Medical Services, Hat Yai, Songkhla, Thailand.

Burkitt lymphoma is an aggressive type of nodal non-Hodgkin lymphoma. This disease commonly involves the gastrointestinal tract, bone marrow, central nervous system, and in rare instances, the skin. We report the case of a 78-year-old Asian man who had experienced subacute fever and significant weight loss. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256308PMC

Prevalence of Cancer in Rheumatoid Arthritis: Epidemiological Study Based on the National Health and Nutrition Examination Survey (NHANES).

Cureus 2020 Apr 28;12(4):e7870. Epub 2020 Apr 28.

Internal Medicine, University of Pittsburgh Medical Center (UPMC) Pinnacle, Lancaster, USA.

Rheumatoid arthritis (RA) is a multi-system autoimmune disease with significant morbidity and healthcare burden. It is an inflammatory condition and has been associated with lymphomas, with or without the presence of immunosuppressive therapy. However, the association of rheumatoid arthritis with other malignancies has been inconsistent. Read More

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http://dx.doi.org/10.7759/cureus.7870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255534PMC

Frequency and Molecular Identification of Species among Immunocompromised Patients Referred to Hospitals, Central Iran, 2015-16.

Iran J Parasitol 2020 Jan-Mar;15(1):31-39

Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The purpose of this study was to determine the prevalence and genotype of spp. in different groups of immunocompromised patients admitted to the referral hospitals in center of Iran during 2015-2016.

Methods: This cross-sectional study was conducted on 346 immunocompromised patients (HIV/AIDS, Lymphoma, Leukemia and organ transplants) in referred hospitals from central parts of Iran including Isfahan, Markazi, Yazd and Chaharmahale Bakhtiari provinces. Read More

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Pruritic cutaneous lesions mimicking dermatitis artefacta in the course of mediastinal gray-zone lymphoma.

Postepy Dermatol Alergol 2020 Apr 6;37(2):280-282. Epub 2020 May 6.

Department of Dermatology, University Hospital, Krakow, Poland.

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http://dx.doi.org/10.5114/ada.2020.94850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262819PMC

Updates from the American Society of Hematology 2019 annual meeting: practice-changing studies in treatment-naïve chronic lymphocytic leukemia.

Curr Oncol 2020 Apr 1;27(2):e231-e245. Epub 2020 May 1.

McGill University Health Centre, Montreal, QC.

The 2019 annual meeting of the American Society of Hematology took place 7-10 December in Orlando, Florida. At the meeting, results from key studies in treatment-naïve chronic lymphocytic leukemia (cll) were presented. Of those studies, phase iii oral presentations focused on the efficacy and safety of therapy with inhibitors of Bruton tyrosine kinase (btk) and Bcl-2. Read More

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http://dx.doi.org/10.3747/co.27.6291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253738PMC

Update on the subcutaneous administration of rituximab in Canadian cancer centres.

Curr Oncol 2020 Apr 1;27(2):113-116. Epub 2020 May 1.

Hoffmann-La Roche, Mississauga, ON.

Results of studies comparing subcutaneous (sc) with intravenous (iv) rituximab indicate that the two formulations are comparable in efficacy, but most patients and health care professionals prefer the sc route, commonly because of shorter chair time and reduced risk of infusion-related reactions. Recent Canadian data, including those from the scuba study reported here, support the results of earlier international studies showing a reduction in preparation and administration time with the sc formulation, lower cost of administration, and reduced drug wastage because of the fixed sc dosing. Given the significant time and cost savings of the sc formulation, that formulation is generally preferred over the iv formulation for the treatment of follicular lymphoma, diffuse large B cell lymphoma, and chronic lymphocytic leukemia. Read More

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http://dx.doi.org/10.3747/co.27.6041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253745PMC

Epidemiology of adult and pediatric Burkitt lymphoma in Canada: sequelae of the HIV epidemic.

Curr Oncol 2020 Apr 1;27(2):83-89. Epub 2020 May 1.

Division of Dermatology, McGill University, Montreal, QC.

Background: Although the pathogenesis and epidemiology of endemic Burkitt lymphoma (bl) have been extensively studied, the epidemiologic landscape of sporadic and immunodeficiency-associated bl in North America remains poorly understood.

Methods: We used 3 distinct population-based cancer registries to retrospectively study bl incidence and mortality in Canada. Data for patient sex; age at the time of diagnosis; and reporting province, city, and forward sortation area (fsa, the first three characters of a postal code) were analyzed. Read More

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http://dx.doi.org/10.3747/co.27.5775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253744PMC

Lenalidomide plus rituximab Vs rituximab alone in relapsed or refractory indolent lymphoma: A cost-effectiveness analysis.

Cancer Med 2020 Jun 2. Epub 2020 Jun 2.

Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Background: The aim of the study was to evaluate the cost-effectiveness of lenalidomide plus rituximab vs rituximab alone in patients with relapsed or refractory indolent lymphoma.

Methods: A Markov decision model was established to carry out the cost-effectiveness analysis. Three discrete health states, progression-free survival (PFS), progressive disease (PD), and death, were included. Read More

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http://dx.doi.org/10.1002/cam4.3121DOI Listing

Atrial fibrillation in patients with chronic lymphocytic leukemia (CLL) treated with ibrutinib: risk prediction, management, and clinical outcomes.

Ann Hematol 2020 Jun 1. Epub 2020 Jun 1.

Division of Hematology, Department of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Background: Ibrutinib therapy is associated with an increased risk of atrial fibrillation (AF) in chronic lymphocytic leukemia (CLL). Risk assessment tools and outcomes of AF in these patients are not well described.

Methods: We performed a retrospective review of patients with CLL treated with ibrutinib at Mayo Clinic between October 2012 and November 2018. Read More

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http://dx.doi.org/10.1007/s00277-020-04094-3DOI Listing

Immunosuppression therapy is effective for both acquired tumor-associated and primary pure red cell aplasia: a match pair case-control study.

Ann Hematol 2020 Jun 1. Epub 2020 Jun 1.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

No agreement had been reached on the treatment of patients with pure red cell aplasia (PRCA) secondary to indolent malignancies. Data was collected from patients with acquired PRCA from May, 2014 to May, 2018 in Peking Union Medical College Hospital. Tumor-associated PRCA and primary PRCA patients were matched at a ratio of 1:2 with compatible baseline characteristics. Read More

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http://dx.doi.org/10.1007/s00277-020-04105-3DOI Listing

Impact of ABVD chemotherapy on ovarian reserve after fertility preservation in reproductive-aged women with Hodgkin lymphoma.

J Assist Reprod Genet 2020 Jun 2. Epub 2020 Jun 2.

Accredited Group on Reproductive Medicine, Institute of Health Investigation La Fe, University Hospital La Fe, Valencia, Spain.

Research Question: How is ovarian reserve affected by chemotherapy in patients with Hodgkin lymphoma (HL) who undergo fertility preservation (FP)?

Methods: A retrospective study was conducted by reviewing medical records of 105 HL patients referred to the FP unit before starting adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy. Ovarian reserve was evaluated before chemotherapy and at the last follow-up using anti-Müllerian hormone (AMH) and antral follicle count (AFC) measurements. The decrease in AMH was compared with that expected from normograms. Read More

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http://dx.doi.org/10.1007/s10815-020-01844-0DOI Listing

Cutaneous Involvement in Waldenström's Macroglobulinaemia.

Acta Derm Venereol 2020 May 25. Epub 2020 May 25.

Department of Oncodermatology, Robert Debré Hospital, avenue du Général Koenig, FR-51092 Reims Cedex, France. E-mail:

Cutaneous involvement in Waldenström's macroglobulinaemia (WM) has been poorly characterized. To describe this involvement, a retrospective study of 19 patients with WM and cutaneous involvement of tumour B-cells was performed. Twelve patients (group 1) had lymphoplasmocytic, non-transformed cutaneous proliferation, while in 7 cases (group 2) cutaneous involvement corresponded to histological transformation. Read More

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http://dx.doi.org/10.2340/00015555-3535DOI Listing

Comparative Effects of Alpha- and Gamma-Tocopherol on Mitochondrial Functions in Alzheimer's Disease In Vitro Model.

Sci Rep 2020 Jun 2;10(1):8962. Epub 2020 Jun 2.

Department of Biochemistry, Level 17, Preclinical Building, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia.

Vitamin E acts as an antioxidant and reduces the level of reactive oxygen species (ROS) in Alzheimer's disease (AD). Alpha-tocopherol (ATF) is the most widely studied form of vitamin E besides gamma-tocopherol (GTF) which also shows beneficial effects in AD. The levels of amyloid-beta (Aβ) and amyloid precursor protein (APP) increased in the brains of AD patients, and mutations in the APP gene are known to enhance the production of Aβ. Read More

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http://dx.doi.org/10.1038/s41598-020-65570-4DOI Listing

[Clinical features and imaging analysis of primary bone lymphoma of the jaw].

Zhonghua Kou Qiang Yi Xue Za Zhi 2020 Jun;55(6):383-387

Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinical characteristics and imaging manifestations of primary bone lymphoma (PBL) located in the jaw. Clinical data of 14 PBL patients admitted to The First Affiliated Hospital of Zhengzhou University from January 2014 to April 2019 were retrospectively analyzed, which including age, gender, location, chief complaint, laboratory test, imaging manifestations and so on. Among the 14 PBL patients, 10 were male and 4 were female. Read More

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http://dx.doi.org/10.3760/cma.j.cn112144-20200105-00003DOI Listing

[Mediastinal T lymphoblastic lymphoma/leukemia: clinicopathological and prognostic analyses of 61 cases].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):601-606

Department of Pathology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinicopathologic features and prognosis of mediastinal T lymphoblastic lymphoma/leukemia (T-LBL/ALL). Sixty-one patients with mediastinal T-LBL/ALL diagnosed at First Affiliated Hospital of Zhengzhou University from August 1, 2011 to December 31, 2018 were enrolled. Their clinical, pathological, imaging features and prognosis were retrospectively analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20190929-00538DOI Listing

[Expression of CDK6 and FOXM1 in peripheral T-cell lymphoma and their significance].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):594-600

Cancer Prevention and Treatment Institute, Yangquan 045000, China.

To investigate the expression of CDK6 and FOXM1 in peripheral T-cell lymphoma (PTCL), and its correlation with clinicopathologic features and patient prognosis. The Oncomine was used for data mining and analyzing the expression levels of CDK6 and FOXM1 in PTCL. Immunohistochemistry (IHC) of EnVision method was used to detect the expression of CDK6 and FOXM1 proteins in 166 cases of PTCL diagnosed at Shanxi Provincial Cancer Hospital from January 2016 to December 2018, and 30 cases of lymph node with reactive hyperplasia as control. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20191104-00710DOI Listing

Beneficial Effects of Inflammatory Cytokine-Targeting Aptamers in an Animal Model of Chronic Prostatitis.

Int J Mol Sci 2020 May 31;21(11). Epub 2020 May 31.

Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.

Non-bacterial prostatitis is an inflammatory disease that is difficult to treat. Oligonucleotide aptamers are well known for their stability and flexibility in conjugating various inflammatory molecules. In this study, we investigated the effects of inflammatory cytokine-targeting aptamers (ICTA), putative neutralizers of TNF-alpha and IL-1 beta activation, on local carrageenan-induced prostate inflammation, allodynia, and hyperalgesia in rats. Read More

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http://dx.doi.org/10.3390/ijms21113953DOI Listing

Virulence Potential of a Multidrug-Resistant Strain Belonging to the Emerging Clonal Group ST101-B1 Isolated from Bloodstream Infection.

Microorganisms 2020 May 30;8(6). Epub 2020 May 30.

Disciplina de Microbiologia, Departamento de Microbiologia, Imunologia e Parasitologia-DMIP, Universidade Federal de São Paulo-Escola Paulista de Medicina (UNIFESP-EPM), São Paulo-SP 04023-062, Brazil.

Escherichia coli EC121 is a multidrug-resistant (MDR) strain isolated from a bloodstream infection of an inpatient with persistent gastroenteritis and T-zone lymphoma that died due to septic shock. Despite causing an extraintestinal infection, previous studies showed that it did not have the usual characteristics of an extraintestinal pathogenic Instead, it belonged to phylogenetic group B1 and harbored few known virulence genes. To evaluate the pathogenic potential of strain EC121, an extensive genome sequencing and in vitro characterization of various pathogenicity-associated properties were performed. Read More

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http://dx.doi.org/10.3390/microorganisms8060827DOI Listing

Mitochondria: A Galaxy in the Hematopoietic and Leukemic Stem Cell Universe.

Int J Mol Sci 2020 May 30;21(11). Epub 2020 May 30.

Department of Clinical and Biological Sciences, University of Turin, Orbassano, 10043, Italy.

Mitochondria are the main fascinating energetic source into the cells. Their number, shape, and dynamism are controlled by the cell's type and current behavior. The perturbation of the mitochondrial inward system via stress response and/or oncogenic insults could activate several trafficking molecular mechanisms with the intention to solve the problem. Read More

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http://dx.doi.org/10.3390/ijms21113928DOI Listing

CAR-T Cell Therapies: An Overview of Clinical Studies Supporting Their Approved Use against Acute Lymphoblastic Leukemia and Large B-Cell Lymphomas.

Int J Mol Sci 2020 May 30;21(11). Epub 2020 May 30.

Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.

Chimeric Antigen Receptor (CAR)-T cell therapy is an exciting development in the field of cancer immunology, wherein immune T-cells from patients are collected, engineered to create 'CAR'-T cells, and infused back into the same patient. Currently, two CAR-T-cell-based therapies, Tisagenlecleucel and Axicabtagene ciloleucel, are approved by FDA for the treatment of hematological malignancies, acute lymphoblastic leukemia and large B-cell lymphomas. Their approval has been a culmination of several phase I and II clinical studies, which are the subject of discussion in this review article. Read More

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http://dx.doi.org/10.3390/ijms21113906DOI Listing

Synthetic ()-3-Phenyl-5-(phenylamino)-2-styryl-1,3,4-thiadiazol-3-ium Chloride Derivatives as Promising Chemotherapy Agents on Cell Lines Infected with HTLV-1.

Molecules 2020 May 29;25(11). Epub 2020 May 29.

Instituto de Química, Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropédica, Rio de Janeiro 23.890-000, Brazil.

Synthesis of four compounds belonging to mesoionic class, (E)-3-phenyl-5-(phenylamino)-2-styryl-1,3,4-thiadiazol-3-ium chloride derivatives (-) and their biological evaluation against MT2 and C92 cell lines infected with human T-cell lymphotropic virus type-1 (HTLV-1), which causes adult T-cell leukemia/lymphoma (ATLL), and non-infected cell lines (Jurkat) are reported. The compounds were obtained by convergent synthesis under microwave irradiation and the cytotoxicity was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Results showed IC values of all compounds in the range of 1. Read More

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http://dx.doi.org/10.3390/molecules25112537DOI Listing

Novel aspects on gonadotoxicity and fertility preservation in lymphoproliferative neoplasms.

Crit Rev Oncol Hematol 2020 May 15;151:102981. Epub 2020 May 15.

Haematology Unit, National Cancer Center, IRCCS Istituto Tumori "Giovanni Paolo II", viale O. Flacco 65, Bari, Italy. Electronic address:

The topic of fertility preservation in patients with a lymphoproliferative disease offers new aspects of debate, due to the introduction of novel chemotherapeutic regimens and small molecules in the clinical landscape. Cancer related infertility is mostly dependent on gonadotoxic treatments and fertile female patients are today addressed to the oocyte cryopreservation or to ovarian cortex fragment cryopreservation. These methods present advantages and disadvantages, which will be discussed in the present review, together with the options for male patients. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102981DOI Listing

A novel methodology of the myeloid-derived suppressor cells (MDSCs) generation with splenic stroma feeder cells.

Exp Cell Res 2020 May 30:112119. Epub 2020 May 30.

Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, PR China. Electronic address:

Myeloid-derived suppressor cells (MDSCs) are a significant obstacle for immunotherapy of cancer. It is of great clinical relevance to study the mechanism of MDSCs accumulation in mouse spleens and establish a stable method to obtain high-purity MDSCs in vitro for further research. Here, we established a new method for amplifying a large number of highly pure MDSCs in vitro. Read More

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http://dx.doi.org/10.1016/j.yexcr.2020.112119DOI Listing

Post-mortem diagnosis of intravascular large B-cell lymphoma.

J Int Med Res 2020 Jun;48(6):300060520924262

Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.

Intravascular large B-cell lymphoma (IVLBCL) is a rare (<1%), typically aggressive extranodal variant of mature non-Hodgkin B-cell lymphoma. IVLBCL is characterized by malignant lymphoid cells lodged within blood vessels, particularly capillary channels. Herein, we present a case of a 50-year-old man with a history of myeloradiculitis (∼1 year) and paraparesis requiring hospitalization. Read More

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http://dx.doi.org/10.1177/0300060520924262DOI Listing

Elimination of dormant, autophagic ovarian cancer cells and xenografts through enhanced sensitivity to anaplastic lymphoma kinase inhibition.

Cancer 2020 Jun 2. Epub 2020 Jun 2.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Poor outcomes for patients with ovarian cancer relate to dormant, drug-resistant cancer cells that survive after primary surgery and chemotherapy. Ovarian cancer (OvCa) cells persist in poorly vascularized scars on the peritoneal surface and depend on autophagy to survive nutrient deprivation. The authors have sought drugs that target autophagic cancer cells selectively to eliminate residual disease. Read More

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http://dx.doi.org/10.1002/cncr.32985DOI Listing

Long-term survival among 5-year survivors of adolescent and young adult cancer.

Cancer 2020 Jun 2. Epub 2020 Jun 2.

Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Although there are a growing number of survivors of adolescent and young adult (AYA) cancer, to the authors' knowledge the long-term overall survival (OS) patterns for AYA cancer survivors are underreported. The objective of the current study was to assess the long-term survival of AYA cancer survivors and identify factors associated with diminished long-term survival.

Methods: The authors used The University of Texas MD Anderson Cancer Center's tumor registry to identify 5-year survivors of cancer diagnosed as AYAs (ages 15-39 years) between the years 1970 and 2005, and who were alive 5 years after diagnosis. Read More

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http://dx.doi.org/10.1002/cncr.33003DOI Listing

Maculopathy Associated With Osmotic Blood- Brain Barrier Disruption and Chemotherapy in Patients With Primary CNS Lymphoma.

Ophthalmic Surg Lasers Imaging Retina 2020 May;51(5):S5-S12

Background And Objective: To describe the incidence, characteristics, and risk factors of a pigmentary maculopathy in patients with primary central nervous system (CNS) lymphoma treated with blood-brain barrier disruption (BBBD) therapy.

Patients And Methods: This retrospective chart review included patients with biopsy-proven primary CNS lymphoma treated with or without BBBD therapy who underwent an ophthalmic examination after starting systemic treatment. Clinical data and all available retinal imaging were analyzed. Read More

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http://dx.doi.org/10.3928/23258160-20200108-01DOI Listing

Multiple mutations at exon 2 of RHOA detected in plasma from patients with peripheral T-cell lymphoma.

Blood Adv 2020 Jun;4(11):2392-2403

Leicester Cancer Research Centre and.

The mutational landscape of peripheral T-cell lymphoma (PTCL) is being revealed through sequencing of lymph node samples, but there has been little work on the mutational load that is present in cell-free DNA (cfDNA) from plasma. We report targeted sequencing of cfDNA from PTCL patients to demonstrate c.50G>T (p. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019001075DOI Listing

Activation of CAR and non-CAR T cells within the tumor microenvironment following CAR T-cell therapy.

JCI Insight 2020 May 28. Epub 2020 May 28.

Department of Pathology, Brigham & Women's Hospital, Boston, United States of America.

The mechanisms of CAR-T cell mediated anti-tumor immunity and toxicity remain poorly characterized due to few studies examining the intact tumor microenvironment (TME) following CAR T-cell infusion. Axicabtagene ciloleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy approved for patients with large B-cell lymphoma. We devised multiplex immunostaining and in-situ hybridization assays to interrogate CAR T cells and other immune cell infiltrates in biopsies of diffuse large B-cell lymphoma following axicabtagene ciloleucel infusion. Read More

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http://dx.doi.org/10.1172/jci.insight.134612DOI Listing

Pityriasis Lichenoides Chronica in a Patient With Ankylosing Spondylitis Treated With Etanercept.

J Drugs Dermatol 2020 May;19(5):560-561

Background: Pityriasis lichenoides chronica, a papulosquamous disorder often considered a subtype of pityriasis lichenoides. It is considered a clonal T-cell disorder, which may be associated with cutaneous T-cell lymphoma that may develops in response to foreign antigens.

Case Presentation: We present a 38-year-old male patient with ankylosing spondylitis who was on treatment with etanercept. Read More

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The changing investment in translational science by academic medical centers: HOPE in the Valley of Death.

J Clin Invest 2020 Jun 2. Epub 2020 Jun 2.

Comprehensive Cancer Center and Beckman Research Institute.

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http://dx.doi.org/10.1172/JCI138640DOI Listing

Nonclinical Safety Assessment of Zanubrutinib: A Novel Irreversible BTK Inhibitor.

Int J Toxicol 2020 May/Jun;39(3):232-240

BeiGene (Beijing) Co., Ltd, Changping District, Beijing, People's Republic of China.

Zanubrutinib an oral irreversible Bruton's tyrosine kinase (BTK) inhibitor, is under development for the treatment of a variety of B-cell malignancies and has received accelerated approval by the US Food and Drug Administration for treatment of adult patients with mantel cell lymphoma who have received at least one prior therapy. Zanubrutinib moderately inhibited the human ether- à -go-go-related gene channel with half maximal inhibition concentration (IC) of 9.11 µM and showed neither effects on the cardiovascular system functions in telemetry-implanted dogs nor on the respiratory and central nervous system functions in rats. Read More

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http://dx.doi.org/10.1177/1091581820918511DOI Listing

Third time's a charm? Mobilization of autologous peripheral blood stem cells in patients with two previous failed mobilizations with plerixafor.

Transfusion 2020 Jun 1. Epub 2020 Jun 1.

Division of Transfusion Medicine, Department of Pathology, City of Hope National Medical Center, Duarte, California, USA.

Background: Patients who respond inadequately to plerixafor salvage during autologous peripheral blood stem cell (PBSC) collection are frequently remobilized with plerixafor to collect additional stem cells. However, in patients who fail remobilization, it is unclear whether additional mobilization efforts with plerixafor are useful.

Study Design And Methods: We retrospectively examined the PBSC collections of 15 consecutive patients with lymphoma and multiple myeloma who underwent three mobilizations with plerixafor. Read More

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http://dx.doi.org/10.1111/trf.15853DOI Listing

A case of cutaneous extranodal natural killer/T-cell lymphoma clinically and histopathologically mimicking interface dermatitis.

Australas J Dermatol 2020 Jun 2. Epub 2020 Jun 2.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Extranodal natural killer/T-cell lymphoma (ENKTL) is a rare but aggressive cancer characterised by angiocentric and angiodestructive infiltration by NK-cells, or cytotoxic T-cell types. Histopathologically, ENKTL shows a multinodular or diffuse infiltration localised to vascular structures, resulting in angiodestruction and necrosis. We present a patient with an initially suspected diagnosis of benign interface dermatitis with a differential diagnosis of mycosis fungoides that was later found to be an aggressive extranodal natural killer/T-cell lymphoma of a nasal type and with a dismal prognosis. Read More

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http://dx.doi.org/10.1111/ajd.13304DOI Listing

Follicular lymphoma Grade 1 of the minor duodenal papilla successfully diagnosed by endoscopic papillectomy.

Endoscopy 2020 May 29. Epub 2020 May 29.

Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.

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http://dx.doi.org/10.1055/a-1173-8418DOI Listing

Changes in the Activity of Genes Involved in the Regulation of Hematopoiesis during Tumorigenesis in Irradiated Mice.

Dokl Biol Sci 2020 Mar 1;491(1):57-59. Epub 2020 Jun 1.

Burnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of the Russian Federation, 123098, Moscow, Russia.

We used 183 F1 CBA×C57Bl hybrid mice to study the delayed effects of low-power long-term γ-irradiation at a dose of 12.6 Gy (10 mGy/min) 8 and 10 months after the treatment. Eight months after the treatment we found the increased expression of the transcription factor NFκB and its target genes iNOS and G-SCF in the bone marrow (BM). Read More

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http://dx.doi.org/10.1134/S0012496620020106DOI Listing