6,130 results match your criteria Lymphoma Mediastinal


Processing and Reporting of Cytology Specimens from Mediastinal Lymph Nodes Collected using Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A State-of-the-Art Review.

J Cytol 2020 Apr-Jun;37(2):72-81. Epub 2020 Apr 2.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) is presently the preferred modality for sampling mediastinal lymph nodes. There is an unmet need for standardization of processing and reporting of cytology specimens obtained by EBUS-TBNA. The manuscript is a state-of-the-art review on the technical aspects of processing and reporting of EBUS-TBNA specimens. Read More

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http://dx.doi.org/10.4103/JOC.JOC_100_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315917PMC

Outcome of Primary Mediastinal Large B-cell Lymphoma Using R-CHOP: Impact of a PET Adapted Approach.

Blood 2020 Jun 30. Epub 2020 Jun 30.

BC Cancer, Vancouver, British Columbia, Canada.

Cure rates for primary mediastinal large B-cell lymphoma (PMBCL) have improved with the integration of rituximab. However, the type of primary therapy and role of radiotherapy (RT) remains ill-defined. Herein, we evaluated the outcome of PMBCL primarily treated with R-CHOP and the impact of an end-of-treatment (EOT) FDG-PET scan to guide consolidative RT. Read More

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http://dx.doi.org/10.1182/blood.2019004296DOI Listing

Daily computed tomography image guidance: dosimetric advantages outweigh low-dose radiation exposure for treatment of mediastinal lymphoma.

Radiother Oncol 2020 Jun 25. Epub 2020 Jun 25.

Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

CT-guided treatment delivery can improve target localization in mediastinal lymphoma patients treated with "butterfly" intensity-modulated radiotherapy and deep-inspiration breath hold. Although daily CT imaging adds additional radiation exposure, its use may be justified given the greater normal tissue sparing enabled by PTV margin reduction. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.06.028DOI Listing

Value of metabolic parameters in distinguishing primary mediastinal lymphomas from thymic epithelial tumors.

Cancer Biol Med 2020 May;17(2):468-477

Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

A high rate of unnecessary thymectomies has been reported. This study aimed to distinguish primary mediastinal lymphomas (PMLs) from thymic epithelial tumors (TETs) by evaluating volumetric and metabolic parameters with F-FDG PET/CT. A total of 136 patients who were pathologically diagnosed with TETs or PMLs were enrolled, and F-FDG PET/CT was performed before therapy. Read More

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http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309468PMC

Irradiating Residual Disease to 30 Gy with Proton Therapy in Pediatric Mediastinal Hodgkin Lymphoma.

Int J Part Ther 2020 27;6(4):11-16. Epub 2020 Apr 27.

Department of Radiation Oncology, Emory University, Atlanta, GA, USA.

Background: Local relapse is a predominant form of recurrence among pediatric patients with Hodgkin lymphoma (PHL). Although PHL radiotherapy doses have been approximately 20 Gy, adults with Hodgkin lymphoma receiving 30 to 36 Gy experience fewer in-field relapses. We investigated the dosimetric effect of such a dose escalation to the organs at risk (OARs). Read More

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http://dx.doi.org/10.14338/IJPT-19-00077.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302731PMC

Pediatric thoracic mass lesions: Beyond the common.

Eur J Radiol Open 2020 11;7:100240. Epub 2020 Jun 11.

Edward B. Singleton Department of Radiology, Texas Children's Hospital, 6701 Fannin Street, Houston, TX, 77030 United States.

Thoracic mass lesions can be categorized as originating in one of the three major compartments: a) chest wall and pleura, b) lung parenchyma and airways, c) mediastinum. While some of these, such as lymphoma, are common in both children and adults, others are rare and unique to childhood. The goal of this review is to familiarize radiologists with unusual mass lesions of the pediatric thorax. Read More

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http://dx.doi.org/10.1016/j.ejro.2020.100240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300149PMC

Management of central nervous system relapse in a young patient affected by primary mediastinal large B-cell lymphoma: A case report.

Clin Case Rep 2020 Jun 8;8(6):933-937. Epub 2020 Apr 8.

Institute of Hematology "L. e A. Seràgnoli" University of Bologna Bologna Italy.

In primary mediastinal large B-cell lymphoma, central nervous system (CNS) relapse is an uncommon event with a dismal prognosis. We report about the successful management of CNS relapse with chemoimmunotherapy according to MATRix (methotrexate, cytarabine, thiotepa, and rituximab) protocol followed by autologous stem cell transplant. Read More

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http://dx.doi.org/10.1002/ccr3.2706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303876PMC

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children With Non-Hodgkin Lymphoma.

J Pediatr Hematol Oncol 2020 Jul;42(5):e310-e314

Departments of Pediatric Hematology and Oncology.

The aim of this study is to evaluate the clinical and laboratory findings of pediatric patients with non-Hodgkin lymphoma (NHL) who developed Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Between 2006 and 2018, the medical records of child patients with NHL who developed SJS and TEN were reviewed retrospectively. SJS/TEN developed in 7 of 70 patients with NHL (10%). Read More

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http://dx.doi.org/10.1097/MPH.0000000000001851DOI Listing

A Primary Mediastinal Large B-Cell Lymphoma Patient With COVID-19 Infection After Intensive Immunochemotherapy: A Case Report.

Front Oncol 2020 22;10:924. Epub 2020 May 22.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The outbreak of coronavirus disease 2019 (COVID-19) had become a global public health event. Lymphoma patients need to be distinguished from the general population because of their deficient immune status and intensive anti-tumor treatment. The impacts of cancer subtypes and treatment on COVID-19 infection are unclear. Read More

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http://dx.doi.org/10.3389/fonc.2020.00924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256193PMC

An Unusual Cause of Mediastinal Mass and Chylothorax.

Int J Appl Basic Med Res 2020 Apr-Jun;10(2):143-146. Epub 2020 Apr 2.

Department of Pulmonary Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Mediastinal masses are commonly encountered in clinical practice. The commonly encountered anterior mediastinal masses include those of thymic or thyroid origin, teratomas, and lymphoma. Establishing the diagnosis by histopathology is essential considering the wide range of differential diagnosis and to exclude malignancies. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_6_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289211PMC

Valvular Damage.

J Cardiovasc Echogr 2020 Apr 10;30(Suppl 1):S26-S32. Epub 2020 Apr 10.

Department of Heart, University Hospital of Salerno, Salerno, Italy.

Valvular heart diseases (VHD) may be observed in patients with cancer for several reasons, including preexisting valve lesions, radiotherapy, infective endocarditis, and secondary to the left ventricle dysfunction. The incidence of VHD is especially in younger survivors treated with thoracic radiation therapy for certain malignancies, such as Hodgkin's lymphoma and breast cancer. The mechanism of radiation-induced damage to heart valves is not clear and includes diffuse fibrocalcific thickening of the valve. Read More

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http://dx.doi.org/10.4103/jcecho.jcecho_5_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293871PMC

Adoption of expansion margins to reduce the dose received by the coronary arteries and the risk of cardiovascular events in lymphoma patients.

Pract Radiat Oncol 2020 Jun 18. Epub 2020 Jun 18.

Department of Oncology, University of Torino, Torino, Italy.

Purpose: Mediastinal radiotherapy (RT) in lymphoma patients implies involuntary coronary artery (CA) exposure, resulting in an increased risk of coronary artery disease (CAD). Accurate delineation of CAs may favor their sparing from higher RT doses. However, heart motion impacts on the estimation of the dose received by CAs. Read More

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http://dx.doi.org/10.1016/j.prro.2020.06.005DOI Listing

Extensive multifocal and pleomorphic pulmonary lesions in Waldenström macroglobulinemia: A case report.

World J Clin Cases 2020 Jun;8(11):2305-2311

Department of Hematology, Navy General Hospital of PLA, Beijing 100048, China.

Background: Waldenström macroglobulinemia (WM) is a type of small lymphocytic lymphoma that mainly affects the bone marrow, spleen, and lymph nodes. A subset of patients with WM demonstrates extramedullary involvement (4.4%), and the most frequent extramedullary disease site involved is the lungs (30%). Read More

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http://dx.doi.org/10.12998/wjcc.v8.i11.2305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281034PMC

Primary Resistance to Brigatinib in a Patient with Lung Adenocarcinoma Harboring G1202R Mutation and Rearrangement.

Onco Targets Ther 2020 22;13:4591-4595. Epub 2020 May 22.

Oncology Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, People's Republic of China.

Purpose: Anaplastic lymphoma kinase () inhibitors have transformed the management of non-small-cell lung cancer (NSCLC) patients with gene rearrangement. This paper reports a new resistance mechanism to a second-generation ALK inhibitor, brigatinib.

Case Report: A 43-year-old woman who had no history of smoking was diagnosed with stage IVa (T2bN2M1b) lung adenocarcinoma. Read More

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http://dx.doi.org/10.2147/OTT.S249652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250292PMC

Venoarterial-ECMO-Support Rescue of Obstructive Shock Caused by Bulky Compressive Mediastinal Cancer.

Am J Respir Crit Care Med 2020 Jun 16. Epub 2020 Jun 16.

1Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Médecine Intensive Réanimation, 75651 Paris, France, Pairs, France;

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http://dx.doi.org/10.1164/rccm.202001-0193LEDOI Listing

HHV8-positive, EBV-positive Hodgkin lymphoma-like large B cell lymphoma: expanding the spectrum of HHV8 and EBV-associated lymphoproliferative disorders.

Int J Hematol 2020 Jun 11. Epub 2020 Jun 11.

Hematopathology Unit, Department of Pathology, Hospital Clinic of Barcelona, Barcelona, Spain.

Human herpesvirus type 8 (HHV8) is a gamma herpesvirus known for its role in lymphoid neoplasms, especially in immunosuppressed patients. We describe the case of a 64-year-old male, without known immunodeficiency, with 1-year-long clinical history of mediastinal and abdominal lymphadenopathies and recurrent pulmonary infections. Histopathological evaluation of a mediastinal lymph node revealed the presence of scattered atypical large cells with Hodgkin and Reed-Sternberg morphology in a background of lymphocytes and extensive areas of fibrosis. Read More

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http://dx.doi.org/10.1007/s12185-020-02897-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287409PMC

Gene expression profiling of gray zone lymphoma.

Blood Adv 2020 Jun;4(11):2523-2535

Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada.

Gray zone lymphoma (GZL), a B-cell lymphoma with features intermediate between large B-cell lymphoma (LBCL) and classic Hodgkin lymphoma (cHL), is a rare and poorly defined entity. Alongside GZL, a subset of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) has been described with polymorphic/GZL-like morphology (polymorphic-EBV-L). To fill the important gap in our understanding of the pathogenic process underlying these entities, we performed a gene expression study of a large international cohort of GZL and polymorphic-EBV-L, combined with cHL and primary mediastinal large B-cell lymphoma (PMBCL) cases. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284085PMC

Camrelizumab plus gemcitabine, vinorelbine and pegylated liposomal doxorubicin in relapsed/refractory primary mediastinal B-cell lymphoma: a single-arm, open-label, phase 2 trial.

Clin Cancer Res 2020 Jun 4. Epub 2020 Jun 4.

Department of Bio-therapeutic, Chinese PLA General Hospital

Purpose: Patients with relapsed/refractory primary mediastinal B-cell lymphoma (rrPMBCL) represent a particularly challenging population to treat, with few life-saving treatment options in the context of a dismal prognosis.

Experimental Design: In this open-label, single-arm, phase 2 study, the safety and efficacy of combined regimen of chemotherapy consisting of gemcitabine, vinorelbine and pegylated liposomal doxorubicin (GVD) plus anti-PD-1 antibody camrelizumab was assessed in rrPMBCL. Patients received chemo-immunotherapy every 3 weeks until the second confirmed complete response or up to 12 cycles, followed by camrelizumab monotherapy for up to 1 year. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-20-0514DOI Listing

Molecular Classification and Treatment of Diffuse Large B-Cell Lymphoma and Primary Mediastinal B-Cell Lymphoma.

Cancer J 2020 May/Jun;26(3):195-205

From the Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Diffuse large B-cell lymphoma (DLBCL) encompasses a group of aggressive B-cell non-Hodgkin lymphomas with striking genetic heterogeneity and variable clinical presentations. Among these is primary mediastinal B-cell lymphoma (PMBL), which has unique clinical and molecular features resembling Hodgkin lymphoma. Treatment of DLBCL is usually curative, but identifiable subsets at highest risk for treatment failure may benefit from intensified chemotherapy regimens and/or targeted agents added to frontline therapy. Read More

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http://dx.doi.org/10.1097/PPO.0000000000000450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285963PMC

Pruritic cutaneous lesions mimicking dermatitis artefacta in the course of mediastinal gray-zone lymphoma.

Postepy Dermatol Alergol 2020 Apr 6;37(2):280-282. Epub 2020 May 6.

Department of Dermatology, University Hospital, Krakow, Poland.

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http://dx.doi.org/10.5114/ada.2020.94850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262819PMC

[Mediastinal T lymphoblastic lymphoma/leukemia: clinicopathological and prognostic analyses of 61 cases].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):601-606

Department of Pathology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinicopathologic features and prognosis of mediastinal T lymphoblastic lymphoma/leukemia (T-LBL/ALL). Sixty-one patients with mediastinal T-LBL/ALL diagnosed at First Affiliated Hospital of Zhengzhou University from August 1, 2011 to December 31, 2018 were enrolled. Their clinical, pathological, imaging features and prognosis were retrospectively analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20190929-00538DOI Listing

Vena cava superior syndrome in the children with mediastinal tumors: Single-center experience.

North Clin Istanb 2020 9;7(3):255-259. Epub 2020 Apr 9.

Division of Pediatric Hematology-Oncology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Objective: Vena cava superior syndrome comprises various symptoms of compression of vena cava superior. The results of increased venous pressure in the upper body may cause edema of the head and neck associated with cyanosis, plethora and distended subcutaneous vessels. Vena cava superior syndrome is rare in childhood. Read More

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http://dx.doi.org/10.14744/nci.2019.46354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251265PMC

Primary mediastinal large B-cell lymphoma in paediatric and adolescent patients: emerging questions in the era of immunotherapy.

Br J Haematol 2020 May 29. Epub 2020 May 29.

Division of Pediatrics, Pediatric Stem Cell Transplantation and Cellular Therapy, CARTOX Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1111/bjh.16761DOI Listing

Biology and Treatment Paradigms in T Cell Acute Lymphoblastic Leukemia in Older Adolescents and Adults.

Curr Treat Options Oncol 2020 May 28;21(7):57. Epub 2020 May 28.

Department of Medicine, Section of Hematology-Oncology, The University of Chicago Medicine, 5841 S. Maryland Avenue, MC 2115, Chicago, IL, 60637, USA.

Opinion Statement: T cell acute lymphoblastic leukemia (T-ALL) occurs in approximately 25-30% of adult ALL diagnoses. Historically, B cell ALL (B-ALL) and T-ALL have been treated in the same fashion despite differences in the biology of disease. Outcomes in the adolescent/young adult (AYA) population have improved significantly with the utilization of pediatric-based regimens. Read More

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http://dx.doi.org/10.1007/s11864-020-00757-5DOI Listing

High metabolic heterogeneity on baseline 18FDG-PET/CT scan as a poor prognostic factor for newly diagnosed diffuse large B-cell lymphoma.

Blood Adv 2020 May;4(10):2286-2296

Department of Hematology, Faculty of Medicine, and.

Metabolic heterogeneity (MH) can be measured using 18F-fluorodeoxyglucose (18FDG) positron emission tomography/computed tomography (PET/CT), and it indicates an inhomogeneous tumor microenvironment. High MH has been shown to predict a worse prognosis for primary mediastinal B-cell lymphoma, whereas its prognostic value in diffuse large B-cell lymphoma (DLBCL) remains to be determined. In the current study, we investigated the prognostic values of MH evaluated in newly diagnosed DLBCL. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252551PMC

Lymphomas of the Mediastinum and Their Differential Diagnosis.

Semin Diagn Pathol 2020 May 15. Epub 2020 May 15.

Department of Pathology, Massachusetts General Hospital, Boston, MA.

Lymphoma is the most common malignancy involving the mediastinum but can be challenging to diagnose on small biopsy specimens. This review provides a pattern-based approach to help triage small tissue samples for the diagnosis of mediastinal lymphoid proliferations, with focus on the main primary mediastinal lymphomas. The use of ancillary studies is highlighted, along with considerations to avoid misdiagnosis and scenarios to request additional tissue. Read More

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http://dx.doi.org/10.1053/j.semdp.2020.04.005DOI Listing

Percussion assisted radiation therapy in Hodgkin lymphoma allows a marked reduction in heart dose.

Radiother Oncol 2020 May 21. Epub 2020 May 21.

Department of Oncology, Division of Radiation Oncology, Lausanne University Hospital and University of Lausanne, Switzerland.

Background And Purpose: Early-stage Hodgkin lymphoma (HL) is a highly curable disease but the treatment can induce late complications many years later. Irradiation of the healthy heart is inevitable during radiation treatment of mediastinal sites. We developed a novel method to induce a prolonged apnea-like state that can help decrease the dose to organs at risk during radiation therapy. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.11.009DOI Listing
May 2020
4.363 Impact Factor

Primary Pulmonary B-cell Lymphoma.

Semin Diagn Pathol 2020 May 19. Epub 2020 May 19.

Mayo Clinic Arizona, Division of Hematopathology, Department of Laboratory Medicine and Pathology, Phoenix, Arizona.

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http://dx.doi.org/10.1053/j.semdp.2020.04.002DOI Listing

Venous Thromboembolism in Lymphoma: Risk Stratification and Antithrombotic Prophylaxis.

Cancers (Basel) 2020 05 20;12(5). Epub 2020 May 20.

Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Lymphoma is listed among the neoplasias with a high risk of venous thromboembolism (VTE). Risk factors for VTE appear to differ from risk factors in solid tumors. We review the literature of the last 20 years for reports identifying these risk factors in cohorts consisting exclusively of lymphoma patients. Read More

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http://dx.doi.org/10.3390/cancers12051291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281118PMC

Large-cell lymphoma with features intermediate between Hodgkin's, primary mediastinal B-cell and grey-zone lymphoma: a conundrum on fine needle aspiration cytology.

Cytopathology 2020 May 17. Epub 2020 May 17.

Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno, Italy.

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http://dx.doi.org/10.1111/cyt.12865DOI Listing

Brentuximab vedotin in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone as frontline treatment for patients with CD30-positive B-cell lymphomas.

Haematologica 2020 May 15. Epub 2020 May 15.

University of Pennsylvania, Philadelphia, PA, USA.

We conducted a phase I/II multicenter trial using 6 cycles of brentuximab vedotin (BV) in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) for treatment of patients with CD30-positive (+) B-cell lymphomas. Thirty-one patients were evaluable for toxicity and 29 for efficacy including 22 with primary mediastinal B-cell lymphoma (PMBCL), 5 with diffuse large B-cell lymphoma (DLBCL), and 2 with gray zone lymphoma (GZL). There were no treatment-related deaths; 32% of patients had non-hematological grade 3/4 toxicities. Read More

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http://dx.doi.org/10.3324/haematol.2019.238675DOI Listing
May 2020
5.868 Impact Factor

Two distinct prognostic groups in advanced-stage Hodgkin lymphoma revealed by the presence and site of bulky disease.

Blood Adv 2020 May;4(9):2064-2072

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.

Controversy exists regarding the definition and prognostic significance of bulk in advanced-stage (stage III/IV) Hodgkin lymphoma (ASHL), and bulk location (mediastinum vs other sites) further complicated the setting. This retrospective, multi-institutional study comprised 814 ASHL patients between 2000 and 2010 and aimed to evaluate the significance of bulk in ASHL. End points of interest included progression-free survival (PFS) and overall survival (OS). Read More

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http://dx.doi.org/10.1182/bloodadvances.2019001265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218436PMC

Mucosa-associated lymphoid tissue (MALT) lymphoma developing in ectopic mediastinal thyroid tissue: a case report.

Surg Case Rep 2020 May 11;6(1):97. Epub 2020 May 11.

Department of pathology, Matsue City Hospital, 32-1, Noshira-cho, Matsue, Shimane, 690-8509, Japan.

Background: Normally located in the neck, ectopic mediastinal thyroid tissue consists of very rare ectopic thyroid tissue that does not connect to the thyroid gland. A patient with mucosa-associated lymphoid tissue (MALT) lymphoma that has developed in mediastinal thyroid tissue, to our best knowledge, has not been previously reported.

Case Presentation: A 67-year-old woman presented with a superior mediastinal mass that was revealed by chest computed tomography (CT), an optional examination she hoped, during a medical checkup. Read More

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http://dx.doi.org/10.1186/s40792-020-00857-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214558PMC

Prognostic factors, therapeutic approaches, and distinct immunobiologic features in patients with primary mediastinal large B-cell lymphoma on long-term follow-up.

Blood Cancer J 2020 May 4;10(5):49. Epub 2020 May 4.

Duke University Medical Center, Division of Hematopathology and Department of Pathology, Durham, NC, USA.

Primary mediastinal large B-cell lymphoma (PMBCL) is a rare and distinct subtype of diffuse large B-cell lymphoma (DLBCL) without prognostic factors or a single standard of treatment clearly defined. In this study we performed retrospective analysis for clinical outcomes of 166 patients with PMBCL. In overall PMBCL, higher International Prognostic Index, stage, Ki-67 proliferation index, and positron emission tomography (PET) maximum standardized uptake values (SUVmax) at diagnosis were significantly associated with poorer survival, whereas MUM1 expression and higher peripheral blood lymphocyte/monocyte ratios were significantly associated with better survival. Read More

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http://dx.doi.org/10.1038/s41408-020-0312-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198569PMC

Brentuximab vedotin demonstrates an objective response in a patient with refractory CD30+ primary mediastinal B-cell lymphoma.

J Cancer Res Ther 2020 Jan-Mar;16(1):183-185

Division of Hematology/Oncology, Department of Internal Medicine, Texas Tech University of Health Sciences Center, El Paso, Texas, USA.

Diffuse large B-cell lymphomas (DLBCL) with MYC translocations combined with translocations involving BCL-2 or BCL-6 are referred to as double-hit lymphomas. These lymphomas are generally refractory to currently available therapies and have a poor prognosis. Primary mediastinal B-cell lymphoma (PMBL) is a rare subtype of DLBCL, which shares clinical, pathologic, and genetic similarities with classical Hodgkin's lymphoma. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_696_16DOI Listing

[A tularemia mimicking lymphoma].

Rev Med Interne 2020 Apr 29. Epub 2020 Apr 29.

Service de médecine interne, hôpital Ambroise-Paré, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.

Introduction: Adenopathies are a frequent cause of recourse in internal medicine. When histological analysis reveals the presence of granuloma, multiple infectious or non-infectious etiologies are considered. If diagnoses of lymphoma, sarcoidosis or tuberculosis are easily mentioned, tularemia should also be considered in the differential diagnosis. Read More

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http://dx.doi.org/10.1016/j.revmed.2020.03.008DOI Listing

Residual Site Radiotherapy After Immunochemotherapy in Primary Mediastinal B-Cell Lymphoma: A Monoinstitutional Retrospective Study.

In Vivo 2020 May-Jun;34(3):1407-1413

Radiotherapy Oncology, Department of Medicine and Surgery and Translational Medicine, Sapienza University of Rome, S. Andrea Hospital, Rome, Italy.

Aim: To evaluate the efficacy of residual site radiation therapy (RSRT) on local control (LC), progression-free (PFS) and overall (OS) survival in patients with primary mediastinal lymphoma (PMBCL), following rituximab and chemotherapy treatment (ICHT).

Patients And Methods: The study included 34 patients with PMBCL treated between 2006 and 2014 with ICHT with/without autologous stem cell transplantation and RSRT. Between the end of ICHT/stem cell transplantation and RSRT, patients were evaluated with F-fluorodeoxyglucose positron-emission tomography. Read More

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http://dx.doi.org/10.21873/invivo.11921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279787PMC
February 2020

EMA Review of Axicabtagene Ciloleucel (Yescarta) for the Treatment of Diffuse Large B-Cell Lymphoma.

Oncologist 2020 Apr 27. Epub 2020 Apr 27.

European Medicines Agency, Amsterdam, The Netherlands.

On June 28, 2018, the Committee for Advanced Therapies and the Committee for Medicinal Products for Human Use adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Yescarta for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma, after two or more lines of systemic therapy. Yescarta, which was designated as an orphan medicinal product and included in the European Medicines Agency's Priority Medicines scheme, was granted an accelerated review timetable. The active substance of Yescarta is axicabtagene ciloleucel, an engineered autologous T-cell immunotherapy product whereby a patient's own T cells are harvested and genetically modified ex vivo by retroviral transduction using a retroviral vector to express a chimeric antigen receptor (CAR) comprising an anti-CD19 single chain variable fragment linked to CD28 costimulatory domain and CD3-zeta signaling domain. Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0646DOI Listing

[Clinical Characteristics and Prognostic Factors of Children with Non-Hodgkin's Lymphoma of Different Pathological Subtypes].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Apr;28(2):500-506

Department of Pediatric Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China,E-mail:

Objective: To investigate the clinical characteristics and prognostic factors of children with non-Hodgkin's lymphoma of different pathological subtypes.

Methods: Ninety-three patients with newly-diagnosed childhood NHL in Fujian Medical University Union Hospital from March 2011 to September 2017 were salected. The diagnosis of patients was performed according to the World Health Organization classification of tumors 2008 ys. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.02.024DOI Listing

[Clinical Characteristics and Prognosis of 56 Lymphoma Patients with Mediastinal Masses].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Apr;28(2):495-499

Department of Hematology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People Hospital), Nanjing 210029, Jiangsu Province, China,E-mail:

Objective: To analyze the incidence, clinical characteristics, treatment efficacy and prognosis of lymphoma patients with mediastinal masses.

Methods: The clinical data of 56 lymphoma patients with mediastinal masses treated in our hospital from February 2007 to January 2018 were collected, and the clinical characteristics, typing, staging, treatment efficacy as well as prognosis analyzed retrospectively.

Results: Among the 56 patients, male and female were 25 (45%) cases and 31(55%) cases, respectively. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.02.023DOI Listing

[The prognostic significance of POD24 in 106 cases with splenic marginal lymphoma with bone marrow invasion].

Zhonghua Xue Ye Xue Za Zhi 2020 Mar;41(3):228-233

State Key Laboratory of Experimental Hematology, National Clinical Research Centre for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

To explore the effect of progression of disease within 24 months (POD24) on overall survival (OS) of splenic marginal lymphoma (SMZL) with bone marrow invasion, and to compare the clinical characteristics between POD24 SMZL with non-POD24 SMZL patients. The SMZL patients with bone marrow invasions were retrospectively analyzed between January 2002 and January 2017 treated in our institute, and the patients with sufficient follow-up time to judge POD24 were evaluated the clinical characteristics and prognosis, patients who died of non-progressive factors were excluded. 106 patients were enrolled with a median age of 57 (25-79) years old. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.03.008DOI Listing

[Autologous hematopoietic stem cell transplantation treatment for T cell lymphoblastic lymphoma].

Zhonghua Xue Ye Xue Za Zhi 2020 Mar;41(3):198-203

Department of Hematology, The First Affiliiliated Hospital of Soochow University, Jiangsu Insititute of Hematology, Suzhou 215006, China.

To investigate the efficacy and predictors of autologous hematopoietic stem cell transplantation (auto-HSCT) in the treatment of T lymphoblastic lymphoma (T-LBL) . 41 patients with T-LBL who underwent auto-HSCT from April 2006 to July 2017 in the Department of Hematology, the First Affiliated Hospital of Soochow University and the Department of Lymphoma, Peking University Cancer Hospital were analyzed retrospectively. ①Among 41 patients, there were 30 males and 11 females with median age of 24 (11-53) years old. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.03.003DOI Listing

Diagnostic performance of 19-gauge endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in suspected lymphoma: A prospective cohort study.

Clin Respir J 2020 Apr 19. Epub 2020 Apr 19.

Department of Respiratory Medicine, Royal Melbourne Hospital, Parkville, VIC, Australia.

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) represents a minimally invasive approach in the evaluation of mediastinal/hilar lymphadenopathy. Diagnostic performance of EBUS-TBNA in lymphoma using standard 22-gauge (22G) needle is limited by sample volumes that are often inadequate for histopathological assessment.

Objectives: To evaluate the diagnostic utility of 19-gauge (19G) EBUS-TBNA needle in the evaluation of suspected lymphoma. Read More

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http://dx.doi.org/10.1111/crj.13198DOI Listing

The cytological evaluation of ascitic fluid led to the diagnosis of mediastinal T lymphoblastic lymphoma- A simplified algorithmic approach to diagnosis of lymphoid cell rich effusion.

Cytopathology 2020 Apr 18. Epub 2020 Apr 18.

Department of Medical Oncolog, JIPMER, Puducherry, India.

Serous effusions in cases of lymphoma are a known and expected phenomenon in the late stages of the disease. The frequency is highest in pleural fluid (20-30%), followed by peritoneal and pericardial involvement. (1) Lymphoblastic lymphoma/leukemia is the most frequent culprit to involve serous fluids. Read More

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http://dx.doi.org/10.1111/cyt.12837DOI Listing
April 2020
1.481 Impact Factor

Computed tomography (CT)-derived radiomic features differentiate prevascular mediastinum masses as thymic neoplasms versus lymphomas.

Radiol Med 2020 Apr 18. Epub 2020 Apr 18.

Department of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini, 4, 20090, Pieve Emanuele, Milano, Italy.

Objectives: We aimed to assess the ability of radiomics, applied to not-enhanced computed tomography (CT), to differentiate mediastinal masses as thymic neoplasms vs lymphomas.

Methods: The present study was an observational retrospective trial. Inclusion criteria were pathology-proven thymic neoplasia or lymphoma with mediastinal localization, availability of CT. Read More

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http://dx.doi.org/10.1007/s11547-020-01188-wDOI Listing

Subclinical Cardiac Dysfunction in Childhood Cancer Survivors on 10-Years Follow-Up Correlates With Cumulative Anthracycline Dose and Is Best Detected by Cardiopulmonary Exercise Testing, Circulating Serum Biomarker, Speckle Tracking Echocardiography, and Tissue Doppler Imaging.

Front Pediatr 2020 31;8:123. Epub 2020 Mar 31.

Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.

Survivors of childhood cancer are at risk for anthracycline- and/or radiotherapy-induced cardiotoxicity. The aim of this study was to assess clinical, laboratory, and imaging parameters of subclinical cardiovascular disease in childhood cancer survivors. Patients underwent cardiopulmonary exercise test (CPET), laboratory testing, transthoracic echocardiography (TTE) with tissue doppler imaging (TDI) and speckle tracking. Read More

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http://dx.doi.org/10.3389/fped.2020.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136405PMC

Diagnostic yield of rapid on-site evaluation transbronchial needle aspiration versus conventional transbronchial needle aspiration: a single center experience.

Monaldi Arch Chest Dis 2020 Apr 15;90(1). Epub 2020 Apr 15.

Department of Thoracic Surgery, Monaldi Hospital, A.O. dei Colli, Naples.

Trans-bronchial needle aspiration allows lymph node sampling in several thoracic conditions; the ability of Rapid On-Site Evaluation (ROSE) to predict the final diagnosis in this setting has not been well characterized. We performed a retrospective study to establish the utility of ROSE in the diagnosis of thoracic diseases with mediastinal lymph node involvement. We retrospectively reviewed 297 patients with hilar-mediastinal lymph node enlargement detected at CT scan from January 2013 to April 2016. Read More

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http://dx.doi.org/10.4081/monaldi.2020.1144DOI Listing

Novel Findings on SPECT-CT Tc-99 Sestamibi Imaging for Primary Hyperparathyroidism.

J Surg Res 2020 Aug 11;252:216-221. Epub 2020 Apr 11.

Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:

Background: The addition of SPECT-CT to Tc-99 sestamibi has become a valuable tool for parathyroid localization in primary hyperparathyroidism (PHP). However, the enhanced sensitivity of this test can lead to unexpected and significant findings. We sought to identify the frequency and types of nonparathyroid detections by SPECT-CT. Read More

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http://dx.doi.org/10.1016/j.jss.2020.03.014DOI Listing

Pre-Intubation Veno-Venous Extracorporeal Membrane Oxygenation in Patients at Risk for Respiratory Decompensation.

J Extra Corpor Technol 2020 Mar;52(1):52-57

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Veno-venous extracorporeal membrane oxygenation (VV-ECMO) has emerged as a potential life-saving treatment for patients with acute respiratory failure. Given the accumulating literature supporting the use of VV-ECMO without therapeutic levels of anticoagulation, it might be feasible to use it for planned intubation before surgical procedures. Here, we report consecutive series of patients who underwent planned initiation of VV-ECMO, without anticoagulation, before induction of general anesthesia for anticipated difficult airways or respiratory decompensation. Read More

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http://dx.doi.org/10.1182/JECT-1900035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138124PMC