6,364 results match your criteria Lymphoma Mediastinal


Molecular classification of aggressive lymphomas-past, present, future.

Hematol Oncol 2021 Jun;39 Suppl 1:24-30

Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany.

Aggressive large B-cell lymphomas (LBCLs) represent a frequent but clinically and molecularly heterogeneous group of tumors. Technological advances over the last decades prompted the development of different classification schemas to either sharpen diagnoses, dissect molecular heterogeneity, predict outcome, or identify rational treatment targets. Despite increased diagnostic precision and a noticeably improved molecular understanding of these lymphomas, clinical perspectives of patients largely remain unchanged. Read More

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Generalised lymphadenopathy in a patient with fever of unknown origin as a differential diagnostic challenge - case report.

J Pak Med Assoc 2021 May;71(5):1489-1492

Department of Infectious diseases, Faculty of Medical Sciences, University of Kragujevac, Serbia.

Fever of unknown origin (FUO) presents a major diagnostic challenge as it is a consequence of many infectious as well as malignant, rheumatologic and other diseases. Here we present the case of a woman with mediastinal and abdominal lymphadenopathy who was initially suspected to have lymphoproliferative disease, but our histopathologic examination revealed sarcoidosis. Sarcoidosis, especially chronic, is a rare cause of FUO, because it usually manifests as a febrile condition. Read More

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Pemphigus Vulgaris After COVID-19: a Case of Induced Autoimmunity.

SN Compr Clin Med 2021 May 27:1-5. Epub 2021 May 27.

Department of Pathology, Federal University of Pernambuco, Recife, PE Brazil.

Bullae autoimmune diseases can be induced by environmental factors in a genetically susceptible individual, and viruses may be important triggers for this process. Coronavirus disease 2019 (COVID-19) is a multisystemic disease known for developing many types of skin lesions. However, little is known about post-COVID-19 manifestations. Read More

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Mediastinal Lymphoproliferative Disorders.

Adv Anat Pathol 2021 Jun 2. Epub 2021 Jun 2.

Department of Pathology and Laboratory Services, University of Arkansas for Medical Sciences, Little Rock, AR.

Lymphoproliferative disorders comprise 50% to 60% of all mediastinal malignancies in both children and adults. Primary mediastinal involvement is rare (∼5%), whereas secondary mediastinal involvement by systemic disease is more common (10% to 25%). Primary mediastinal disease is defined as involvement by a lymphoproliferative disorder of mediastinal lymph nodes, the thymus, and/or extranodal mediastinal organs without evidence of systemic disease at presentation. Read More

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Sarcoid-Like Reaction in Non-Hodgkin's Lymphoma-A Diagnostic Challenge for Deauville Scoring on F-FDG PET/CT Imaging.

Diagnostics (Basel) 2021 May 31;11(6). Epub 2021 May 31.

Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.

The sarcoid-like reaction represents an autoinflammatory cause of mediastinal and hilar lymphadenopathy but may also involve other lymph node regions and organs. This rare phenomenon has mainly been reported in patients with Hodgkin's lymphoma (HL) or solid tumors (particularly melanoma) undergoing immunotherapy and chemotherapy. Cases in non-Hodgkin's lymphoma (NHL) are very uncommon. Read More

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Chronic Chest Pain Control after Trans-Thoracic Biopsy in Mediastinal Lymphomas.

Healthcare (Basel) 2021 May 18;9(5). Epub 2021 May 18.

Pain Department, AORN Dei Colli-V. Monaldi, 80131 Naples, Italy.

Chest pain following a trans-thoracic biopsy often has multiple etiologies, especially in patients with lymphomas. Pathological neuronal mechanisms integrate with an overproduction of IL-6, TNF-α, IL1-β by macrophages and monocytes, which amplifies inflammation and pain. In consideration of this complex pathogenesis, international guidelines recommend diversified analgesia protocols: thoracic epidural, paravertebral block, and systemic administration of opioids. Read More

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Peripheral T-Cell Lymphoma Possibly Due to Unrecognized Celiac Disease in an Elderly Patient: A Case Report.

Medicina (Kaunas) 2021 May 11;57(5). Epub 2021 May 11.

Department of Internal Diseases, Metabolic Disorders and Hypertension, Poznań University of Medical Sciences, Szamarzewskiego 84, 60-569 Poznań, Poland.

Celiac disease (CD) is widely perceived as a childhood disorder. However, it has been demonstrated that 19-34% of new CD cases are diagnosed in patients over 60 years of age and lack the typical presentation. A 76-year-old female was admitted to the clinic due to a recurrent fever that had lasted over a year accompanied by progressive weakness, weight loss of about 10 kg, dehydration, and malnutrition. Read More

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Syncytial Variant of Nodular Sclerosis Hodgkin Lymphoma: An Under-emphasized Variant.

Hum Pathol 2021 May 28. Epub 2021 May 28.

Department of Hematopathology, The University of MD Anderson Cancer Center, Houston, TX, 77030, USA;. Electronic address:

Syncytial variant nodular sclerosis Hodgkin lymphoma (HL) is a variant that was described over 40 years ago, but has received relatively little attention in the literature. Earlier studies emphasized the predominance of Hodgkin (also known as lacunar) and Reed-Sternberg (HRS) cells in this variant. Here we emphasize that the HRS cells in syncytial variant nodular sclerosis HL have a cohesive appearance, form confluent sheets, and have an immunophenotype typical of classic HL. Read More

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Outcome of first relapse of Hodgkin lymphoma: single institution experience.

J Pak Med Assoc 2021 Mar;71(3):883-888

Department of Pediatric Hematology Division, Tawam Hospital, Alain, Abu Dhabi, UAE.

Objective: To determine outcome of first relapse of Hodgkin lymphoma with standard dose chemotherapy, and to identify the prognostic factors predicting survival outcome in paediatric patients.

Methods: The retrospective study was conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised data of Hodgkin lymphoma patients who relapsed at least 3 months after the completion of initial treatment from January 2001 to December 2010. Probabilities of overall survival, event-free survival and cumulative incidence were calculated. Read More

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Isolated Splenic Tuberculosis Masquerading as Disease Progression of Hodgkin's Lymphoma on InterimF-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Scan.

Indian J Nucl Med 2021 Jan-Mar;36(1):100-102. Epub 2021 Mar 4.

Department of Pathology, Sir Ganga Ram Hospital, New Delhi, India.

F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) scan is the imaging modality of choice in the management of lymphoma. However, 18F-FDG is a nonspecific tracer for tumoral metabolic activity and infective pathology, thus posing a challenge in accurate response assessment. Here, we present a case of Hodgkin's lymphoma, referred for staging PET/CT scan which showed FDG-avid disease in the mediastinum, and on interim F-FDG PET/CT in addition to the mediastinal mass lesion, a FDG-avid lesion was also noted in the spleen suggestive of disease progression. Read More

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Diffuse Large B-cell Lymphoma: Unexpected Uptake Observed on Cardiac 123I-MIBG Scintigraphy.

Clin Nucl Med 2021 May 26. Epub 2021 May 26.

From the Departments of Diagnostic Imaging and Nuclear Medicine Diagnostic Pathology Neurology, Graduate School of Medicine, Kyoto University, Kyoto City, Japan.

Abstract: A 77-year-old man with parkinsonism was referred to the department of neurology for further examination. Cardiac 123I-MIBG scintigraphy unexpectedly showed strong uptake in the left shoulder, suggestive of MIBG-avid tumors including paraganglioma. MRI revealed multiple nodules suggestive of lymphoma. Read More

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Testicular Plasmablastic Lymphoma in an HIV-Negative Patient: A Rare Case Presentation.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211017423

Marshall University, Huntington, WV, USA.

Plasmablastic lymphoma (PBL) is a very rare disease and it is usually considered a human immunodeficiency virus (HIV)-related B-cell lymphoma that carries a poor prognosis. It mostly involves the oral cavity, lungs, nasal cavity, gastrointestinal tract, lymph node, and skin. Therapeutic regimens like dose-adjusted etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone (DA-EPOCH) have shown better results in these aggressive lymphomas. Read More

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Real-world data on treatment and outcomes of patients with primary mediastinal large B-cell lymphoma: a Swedish lymphoma register study.

Blood Cancer J 2021 May 21;11(5):100. Epub 2021 May 21.

Department of Medicine Solna, Division of Clinical Epidemiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

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EBUS in optimizing non-small cell lung cancer diagnosis and treatment.

Med Pharm Rep 2021 Apr 29;94(2):176-184. Epub 2021 Apr 29.

Leon Daniello Pulmonology Hospital, Cluj-Napoca, Romania.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a commonly used minimally invasive method for the diagnosis and staging of lung cancer. In order to improve its diagnostic accuracy, rapid on-site cytologic evaluation (ROSE) is being utilized in some institutions. ROSE, performed by a cytopathologist in the examination room, allows the assessment of the adequacy of the collected samples, identifies malignant cells and sometimes establishes diagnosis on the spot, thus improving diagnostic sensitivity. Read More

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STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology.

Pathol Res Pract 2021 May 11;223:153477. Epub 2021 May 11.

Pathology Department, University Hospital of Saint-Etienne, France.

Signal Transducer and Activator of Transcription 6 (STAT6), belonging to a family of seven similar members is primarily stimulated by interleukin(IL)-4 and IL-13, and acts as a T helper type 2 (Th2)-inducing factor. Thus, it is implicated in the pathophysiology of various allergic conditions, such as asthma, atopic dermatitis, eosinophilic esophagitis and food allergies, but also in tumor microenvironment regulation. Furthermore, certain forms of lymphomas, notably the Hodgkin lymphoma group, the primary mediastinal and primary central nervous system lymphoma, as well as some follicular and T cell lymphomas are associated with dysregulation of the STAT6 pathway. Read More

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HTLV-1-Associated Lymphoma Presented as Massive Lymphadenopathy.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211013235

Brookdale University Hospital Medical Center, Brooklyn, NY, USA.

Adult T-cell leukemia/lymphoma is an aggressive T-cell malignancy caused by the long-term infection of human T-cell lymphotropic virus type 1 (HTLV-1). Our understanding of clinical features still largely relies on the Shimoyama classification developed 30 years ago, which described the 4 clinical subtypes (the smoldering, chronic, lymphoma, and acute types) based on the manifestations of lymphocytosis, elevated lactate dehydrogenase, hypercalcemia, lymphadenopathy, and involvement of the skin, lung, liver, spleen, central nervous system, bone, ascites, pleural effusion, and gastrointestinal tract. HTLV-1-associated lymphoma has a variety of presentations but the presentation of massive lymphadenopathy and compression symptoms is rare and has not been emphasized in the literature. Read More

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Sarcoidosis mimicking metastases in an echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase positive non-small-lung cancer patient: A case report.

World J Clin Cases 2021 May;9(13):3140-3146

Department of Respiratory Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Background: Rearrangements of the anaplastic lymphoma kinase (ALK) gene (ALK-positive) represent an oncogenic driver in approximately 3%-5% of non-small-lung cancer (NSCLC) patients. Sarcoidosis is a multisystem disease, and its reported incidence in Asia is 1 or less per 100000 people per year. The co-occurrence of sarcoidosis and ALK-positive NSCLC is rare, and ALK-positive lung cancer is likely to spread quickly. Read More

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ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature.

Autops Case Rep 2021 Jan 28;11:e2020231. Epub 2021 Jan 28.

Postgraduate Institute of Medical Education and Research, Department of Gastroenterology, Chandigarh, India.

Cardiac lymphoma is a rare entity. In this setting, the secondary involvement of the heart is far more frequent than the primary cardiac lymphoma. Herein, we present an autopsy case of a disseminated anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma with a dominant mediastinal involvement. Read More

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January 2021

[Diffuse large B-cell lymphoma with mediastinal bulky mass associated with complication of repeated sinus arrest].

Rinsho Ketsueki 2021 ;62(4):262-266

Department of Internal Medicine, Kohsei Chuo General Hospital.

A 71-year-old woman presented to a clinic with the chief complaint of facial edema and dyspnea; chest radiography showed mediastinal mass shadow and right pleural effusion. Computed tomography guided biopsy of the mediastinal mass had been performed by her previous doctor, and she was diagnosed with diffuse large B-cell lymphoma. She was referred to our hospital for chemotherapy. Read More

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Diffuse large B-cell lymphoma in the liver accompanied by primary biliary cholangitis: A rare and difficult-to-diagnose tumor with portal venous thrombosis.

Int J Surg Case Rep 2021 May 30;82:105936. Epub 2021 Apr 30.

Department of Surgery, Shiga General Hospital, Moriyama, 5-4-30 Moriyama, Moriyama, Shiga 524-8524, Japan. Electronic address:

Introduction And Importance: The most common liver malignancies are hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and metastatic tumors. Hepatocellular carcinoma and intrahepatic cholangiocarcinoma may invade the portal vein (PV). An association between diffuse large B-cell lymphoma (DLBCL) and primary biliary cholangitis (PBC) remains unclear. Read More

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Examination of endobronchial ultrasound-guided transbronchial needle aspiration using a puncture needle with a side trap.

Sci Rep 2021 May 7;11(1):9789. Epub 2021 May 7.

Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is useful for diagnosing hilar and mediastinal lymph node enlargement; however, specimens obtained are often small and inadequate for pathologic diagnosis. In June 2017, EchoTip ProCore, a puncture needle with a side trap, was launched in Japan. In this single-center prospective interventional study, 57 patients with lymph nodes, intrapulmonary tumor or pleural mass were diagnosed using EBUS-TBNA with EchoTip ProCore between June 2017 and February 2020. Read More

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Paraneoplastic Limbic Encephalitis Secondary to SCLC on 18F-FDG PET/CT.

Clin Nucl Med 2021 Jun;46(6):494-496

From the Nuclear Medicine Department, NOVA Diagnóstico por Imagem.

Abstract: A 67-year-old man with rapidly neurologic deterioration and 15 kg weight loss in 2 months was extensively evaluated by several medical specialties and conventional image examinations, with no diagnostic definition. 18F-FDG PET/CT was performed, showing glycolytic hypermetabolism in the hippocampus, cerebral hypometabolism with posterior temporoparietal pattern, multiple cervical and supraclavicular lymph nodes, and mediastinal hypermetabolic and enlarged lymph nodes, suggesting paraneoplastic limbic encephalitis, Alzheimer dementia, and lymphoma. Lymph node biopsy resulted in small cell lung carcinoma. Read More

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On the Importance of Individualized, Non-Coplanar Beam Configurations in Mediastinal Lymphoma Radiotherapy, Optimized With Automated Planning.

Front Oncol 2021 15;11:619929. Epub 2021 Apr 15.

Department of Radiotherapy, Erasmus MC Cancer Institute, Rotterdam, Netherlands.

Background And Purpose: Literature is non-conclusive regarding selection of beam configurations in radiotherapy for mediastinal lymphoma (ML) radiotherapy, and published studies are based on manual planning with its inherent limitations. In this study, coplanar and non-coplanar beam configurations were systematically compared, using a large number of automatically generated plans.

Material And Methods: An autoplanning workflow, including beam configuration optimization, was configured for young female ML patients. Read More

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Lymphoma Masquerading as an Ear Mass.

Cureus 2021 Mar 29;13(3):e14180. Epub 2021 Mar 29.

Internal Medicine, University of Texas Health Science Center at Houston, Houston, USA.

Due to the infrequently reported location, malignancies of the ear are usually misdiagnosed at the time of first presentation. To the best of our knowledge, there have been no reports in literature regarding diffuse large B-cell lymphoma (DLBCL) presenting as an ear mass, as was seen in our patient. We describe a case of a 38-year-old gentleman who presented with four months of worsening dyspnea on exertion and nonproductive cough. Read More

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Brentuximab vedotin maintenance after autologous stem cell transplantation for refractory gray zone lymphoma with long-term remission.

Mol Clin Oncol 2021 Jun 23;14(6):125. Epub 2021 Apr 23.

Department of Hematology, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan.

Gray zone lymphoma (GZL) is a rare type of B-cell lymphoma characterized by features of both diffuse large B-cell lymphoma and classical Hodgkin lymphoma (cHL). The prognosis of GZL is poorer than that of cHL and mediastinal large B-cell lymphoma. However, an optimal treatment strategy for relapsed/refractory (R/R) GZL has not been established in the clinical setting. Read More

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Treatment and Outcome Analysis of 639 Relapsed Non-Hodgkin Lymphomas in Children and Adolescents and Resulting Treatment Recommendations.

Cancers (Basel) 2021 Apr 25;13(9). Epub 2021 Apr 25.

Department of Pediatric Hematology, Oncology and BMT, University Hospital Muenster, 48149 Münster, Germany.

Despite poor survival, controversies remain in the treatment for refractory or relapsed pediatric non-Hodgkin lymphoma (r/r NHL). The current project aimed to collect international experience on the re-induction treatment of r/r NHL, hematopoietic stem cell transplantation (HSCT), risk factors associated with outcome, and to suggest treatment recommendations. Inclusion criteria were (i) refractory disease, disease progression or relapse of any NHL subtype except anaplastic large cell lymphoma, (ii) age < 18 years at initial diagnosis, (iii) diagnosis in/after January 2000. Read More

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Mediastinal diffuse large B-cell lymphoma mimicking invasive thymoma on Ga-FAPI PET/CT.

J Nucl Cardiol 2021 Apr 28. Epub 2021 Apr 28.

Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No. 25 TaiPing St, Jiangyang District, Luzhou, 646000, Sichuan, People's Republic of China.

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Chemotherapy During Active SARS-CoV2 Infection: A Case Report and Review of the Literature.

Front Oncol 2021 12;11:662211. Epub 2021 Apr 12.

Department of Oncology, Medical University of Warsaw, Warsaw, Poland.

COVID-19 has become the biggest public health problem and one of the most important causes of death in many countries in the world. SARS-CoV-2 infection is most likely to be fatal in elderly patients with concomitant diseases. In this article we present two cases of asymptomatic SARS-CoV-2-positive patients suffering from cancer who were treated with chemotherapy. Read More

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