6,610 results match your criteria Lymphoma Mediastinal

High efficacy of intensive immunochemotherapy for primary mediastinal B-cell lymphoma with prolonged follow up.

Sci Rep 2022 Jun 22;12(1):10551. Epub 2022 Jun 22.

Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, 5 WK Roentgen Str, 02-781, Warsaw, Poland.

Primary mediastinal B-cell lymphoma (PMBL) is currently curable in 85-95% of patients. Treatment regimens frequently used include RCHOP ± radiotherapy, DAEPOCH-R, or occasionally more intensive protocols. Here we present results of treatment of 124 patients with PMBL over a period between 2004 and 2017 with the use of a protocol designed for aggressive B-cell lymphoma GMALL/B-ALL/NHL2002 including 6 cycles of alternating immunochemotherapy with intermediate-dose methotrexate in each cycle, and reduced total doxorubicin dose (100 mg/m for whole treatment). Read More

View Article and Full-Text PDF

Long-term remission of primary refractory ALK-positive anaplastic large cell lymphoma after allogeneic hematopoietic stem cell transplantation.

J Clin Exp Hematop 2022 Jun 22. Epub 2022 Jun 22.

Department of Hematology, Tohoku University Hospital, Sendai, Japan.

ALK-positive anaplastic large cell lymphoma (ALK+ ALCL) has a favorable prognosis in general; however, some cases are resistant to chemotherapy, which leads to a poor clinical outcome. We herein report the case of a 32-year-old male with aggressive ALK+ ALCL who presented with hemorrhage from a large tumor in the duodenum and multiple tumors in the lungs, mediastinum, and peritoneal cavity. Although induction chemotherapy resulted in a marked reduction of the tumor lesions, premature progression with massive pulmonary infiltration and central nervous system invasion occurred immediately after the completion of chemotherapy. Read More

View Article and Full-Text PDF

[Lisocabtagene maraleucel for patients with relapsed or refractory diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma or follicular lymphoma grade 3B after two or more lines of systemic treatment].

Bull Cancer 2022 Jun 15. Epub 2022 Jun 15.

CHU de Nice, service d'hématologie clinique, Nice, France; Université Côte d'Azur, centre méditerranéen de médecine moléculaire (Inserm U1065), Nice, France. Electronic address:

View Article and Full-Text PDF

Precursor T-Lymphoblastic Lymphoma Presenting With a Cough: A Case Report.

Cureus 2022 May 15;14(5):e25011. Epub 2022 May 15.

Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, IND.

Lymphoblastic lymphoma (LBL) is a rare subtype of non-Hodgkin lymphoma (NHL) and the majority (85-90%) of the cases are comprised of precursor T-lymphoblastic lymphoma (T-LBL). We report a case of a 17-year-old male who presented with a productive cough for one month along with complaints of difficulty in breathing (unrelated to exertion) for four days and chest pain (left-sided, non-radiating) for two days. On clinical examination, lymphadenopathy was observed; mid jugular cervical lymph nodes were palpable on the left side, which were non-tender, matted, and approximately 1 x 1 cm in diameter. Read More

View Article and Full-Text PDF

Less Intensive Regimens May Still Be Suitable for the Initial Treatment of Primary Mediastinal B-Cell Lymphoma in Resource-Limited Settings.

J Oncol 2022 6;2022:2099456. Epub 2022 Jun 6.

Instituto do Cancer do Estado de São Paulo, São Paulo, SP, Brazil.

Primary mediastinal B-cell lymphoma (PMBCL) is an uncommon disease, consisting of 2-4% of non-Hodgkin lymphomas. Radiotherapy-free DA-EPOCH-R and R-CHOP plus radiotherapy (RT) have been the upfront standard regimens worldwide. However, performing DA-EPOCH-R in resource-constrained settings can be burdensome, especially in low/middle-income countries, where data on PMBCL are still largely unknown. Read More

View Article and Full-Text PDF

A Rare Case of Aggressive Peripheral T-cell Lymphoma-Not Otherwise Specified.

Cureus 2022 May 9;14(5):e24857. Epub 2022 May 9.

Internal Medicine, Drexel University College of Medicine, Philadelphia, USA.

Peripheral T-cell lymphomas are an offshoot of non-Hodgkin's lymphomas and usually carry a poor prognosis. Their clinical manifestations could be very variable and can mimic an infectious or autoimmune etiology. Here, we present a case of a 58-year-old healthy female who presented with fever, cough, and shortness of breath for several days. Read More

View Article and Full-Text PDF

Analysis of misdiagnosis and 18F-FDG PET/CT findings of lymph node tuberculosis.

J Xray Sci Technol 2022 Jun 5. Epub 2022 Jun 5.

Department of Radiology, Jiangxi Provincial People's Hospital, he First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.

Objective: To investigate 18F-FDG PET/CT findings of tuberculous lymphadenitis and analyze the causes of misdiagnosis.

Method: Between 2013 and 2021, a retrospective review was conducted on 22 patients at Jiangxi Provincial People's Hospital Affiliated with Nanchang University who had lymph node tuberculosis confirmed by histology or clinical investigation. Subjective judgment and quantitative analysis were adopted. Read More

View Article and Full-Text PDF

Novel HIVEP1-ALK fusion in a patient with lung adenocarcinoma demonstrating sensitivity to alectinib: a case report.

Transl Lung Cancer Res 2022 May;11(5):902-909

Department of Thoracic Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.

Background: Anaplastic lymphoma kinase (ALK) fusion is an important oncogenic driver in non-small cell lung cancer (NSCLC). Reports on the intergenic region (IGR) as an ALK fusion partner are rare. Here, we report the case of a patient with advanced NSCLC harboring a human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1)-ALK fusion that responded effectively to alectinib. Read More

View Article and Full-Text PDF

Cardiotoxicity model-based patient selection for Hodgkin lymphoma proton therapy.

Acta Oncol 2022 Jun 6:1-8. Epub 2022 Jun 6.

Radiation Oncology Clinical Department, Centro Nazionale di Adronterapia Oncologica (CNAO), Pavia, Italia.

Introduction: Hodgkin lymphoma (HL) is a highly curable hematological malignancy. Consolidation radiation therapy techniques have made significant progresses to improve organ-at-risk sparing in order to reduce late radiation-induced toxicity. Recent technical breakthroughs notably include intensity modulated proton therapy (IMPT), which has demonstrated a major dosimetric benefit at the cardiac level for mediastinal HL patients. Read More

View Article and Full-Text PDF

Case Report: Primary Mediastinal Large B-Cell Lymphoma Invasion of Extranodal Thyroid Tissue Mimicking Tuberculosis and Confounded by Similar Ultrasonic Appearance.

Front Oncol 2022 18;12:879295. Epub 2022 May 18.

Department of Ultrasonography, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine. Chinese and Western Hospital of Zhejiang Province (Hangzhou Red Cross Hospital), Hangzhou, China.

Background: Primary mediastinal large B-cell lymphoma (PMBCL) is a rare type of diffuse large B-cell lymphoma, which has significant features that overlap with those of Hodgkin's lymphoma. Ultrasound is a commonly used modality to characterize superficial lymph no5des, and ultrasonic findings are often used to distinguish lymphoma from lymph node tuberculosis in daily clinical practice. Although a common malignancy, lymphoma rarely involves extranodal tissues. Read More

View Article and Full-Text PDF

Multimodality Imaging Guided Diagnosis and Treatment Response Evaluation in a Patient with Lymphoma with Right Atrioventricular Involvement.

Curr Probl Cardiol 2022 Jun 2:101273. Epub 2022 Jun 2.

Department of Cardio-oncology, Gill Heart & Vascular Institute, University of Kentucky, Gill Heart & Vascular Institute, University of Kentucky, Lexington, KY, USA. Electronic address:

A 42-year-old female was transferred to our center from a regional hospital with 5-day history of flushing, fatigue, and chest pressure. On initial presentation to the regional hospital, computed tomography (CT) of chest revealed a large mediastinal mass with cardiac involvement. Supraclavicular lymph node biopsy demonstrated non-germinal center diffuse large B-cell lymphoma with Ki67 index near 100%. Read More

View Article and Full-Text PDF

Computed Tomography-Based Radiomics for Differentiation of Thymic Epithelial Tumors and Lymphomas in Anterior Mediastinum.

Front Oncol 2022 13;12:869982. Epub 2022 May 13.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Objective: To investigate the differential diagnostic performance of computed tomography (CT)-based radiomics in thymic epithelial tumors (TETs) and lymphomas in anterior mediastinum.

Methods: There were 149 patients with TETs and 93 patients with lymphomas enrolled. These patients were assigned to a training set (n = 171) and an external validation set (n = 71). Read More

View Article and Full-Text PDF

High-risk stage IIB Hodgkin lymphoma treated in the H10 and AHL2011 trials: TMTV is a useful risk factor to stratify patients at baseline.

Haematologica 2022 05 31. Epub 2022 May 31.

Department of Hematology, Dijon-Bourgogne University Hospital, Dijon; INSERM unit 1231, University of Burgundy Franche-Comté, France.

Stage IIB Hodgkin lymphoma (HL) patients, with a mediastinum-to-thorax (M/T) ratio of ≥0.33 or extranodal localization have a poor prognosis and are treated either as limited or advanced stage. We compared these two approaches in patients included in two randomized phase III trials enrolling previously untreated early (H10) or advanced stage HL (AHL2011). Read More

View Article and Full-Text PDF

Ectopic Cervical Thymic Hyperplasia In A Patient Treated For Hodgkin Lymphoma.

Ear Nose Throat J 2022 May 29:1455613221106214. Epub 2022 May 29.

Department of Otorhinolaryngology, 518993Habib Bourguiba hospital, Sfax, Tunisia.

True thymic hyperplasia results from stressful situations such as chemotherapy. It commonly presents as an anterior mediastinal mass; cervical location is exceptional. Here we report a case of a cervical true thymic hyperplasia in a 12-year-old girl who had a Hodgkin lymphoma treated by radiotherapy and chemotherapy. Read More

View Article and Full-Text PDF

The Influence of Radiotherapy on the Function of the Left and Right Ventricles in Relation to the Radiation Dose Administered to the Left Anterior Descending Coronary Artery-From a Cardiologist's Point of View.

Cancers (Basel) 2022 May 13;14(10). Epub 2022 May 13.

Second Department of Cardiology, Medical University of Gdansk, 80-210 Gdańsk, Poland.

The aim of this study was to assess the effects of radiotherapy involving the heart on LV and RV function using modern speckle-tracking echocardiography (STE), and in relation to the radiation dose applied to the LAD. This retrospective, single-centre study included 12 patients after a median of 51 months after irradiation for mediastinal lymphoma, in whom we were able to delineate the LAD. Correlations between doses of ionising radiation and echocardiographic parameters reflecting the systolic function of the LV and RV were analysed. Read More

View Article and Full-Text PDF

Unilateral recurrent laryngeal nerve palsy detected by PET/CT in a patient with mediastinal T-cell lymphoblastic lymphoma.

Int J Hematol 2022 Jul 27;116(1):3-4. Epub 2022 May 27.

Department of Hematology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita‑ku, Sapporo, 060‑8638, Japan.

View Article and Full-Text PDF

STR Profiling Reveals Tumor Genome Instability in Primary Mediastinal B-Cell Lymphoma.

Curr Oncol 2022 05 10;29(5):3449-3459. Epub 2022 May 10.

National Medical Research Center for Hematology, Ministry of Health of Russian Federation, 125167 Moscow, Russia.

Primary mediastinal B-cell lymphoma (PMBCL) is the only non-Hodgkin's lymphoma variant responding to immune checkpoint inhibitor (ICI) therapy, approximately in half of the cases; however, no molecular markers predicting a response to ICI therapy in PMBCL have been described so far. In this study, we assessed the incidence of the loss of heterozygosity (LOH), elevated microsatellite alteration at selected tetranucleotides (EMAST), and microsatellite instability (MSI) in the tumor genomes of 72 patients with PMBCL undergoing high-dose chemotherapy treatment at the National Research Center for Hematology (Moscow, Russia). Tumor DNA was isolated from biopsy samples taken at diagnosis. Read More

View Article and Full-Text PDF

Primary mediastinal large B-cell lymphoma is characterized by large-scale copy-neutral loss of heterozygosity.

Genes Chromosomes Cancer 2022 May 25. Epub 2022 May 25.

Centre for Human Genetics, KU Leuven, Leuven, Belgium.

Development of primary mediastinal B-cell lymphoma (PMBL) is driven by cumulative genomic aberrations. We discovered a unique copy-neutral loss of heterozygosity (CN-LOH) landscape of PMBL which distinguishes this tumour from other B-cell malignancies, including the biologically related diffuse large B-cell lymphoma. Using single nucleotide polymorphism array analysis we identified large-scale CN-LOH lesions in 91% (30/33) of diagnostic PMBLs and both investigated PMBL-derived cell lines. Read More

View Article and Full-Text PDF

Rare Case of Mixed Phenotype Acute Leukemia Presenting as a Myeloid Sarcoma Without Leukemic Involvement.

Perm J 2022 Apr 5;26(1):132-136. Epub 2022 Apr 5.

Department of Oncology/Hematology, Kaiser Permanente Santa Clara, Santa Clara, CA, USA.

Introduction: Mixed phenotype acute leukemia (MPAL) is a rare type of acute leukemia with immunophenotypic features of both myeloid-derived and lymphoid-derived lineages.

Case Presentation: We present an atypical case of a 32-year-old woman presenting with an anterior mediastinal mass and pericardial/pleural involvement that was initially diagnosed as primary mediastinal diffuse large B-cell lymphoma. However, flow cytometry on pleural fluid confirmed the diagnosis of MPAL of B-cell/myeloid lineage without peripheral blood/bone marrow involvement. Read More

View Article and Full-Text PDF

What Lies Behind the Cannonball Pulmonary Metastases: Hodgkin's Lymphoma?

Cureus 2022 Apr 21;14(4):e24351. Epub 2022 Apr 21.

Pediatric Hematology, Faculty of Medicine and Pharmacy/Mohammed VI University Hospital, Oujda, MAR.

The cannonball pulmonary appearance is hematogenous dissemination of various primary tumors but rarely a Hodgkin's lymphoma, a disease that most commonly manifests with lymphadenopathy, often affecting the mediastinum and supraclavicular or cervical lymph nodes. To date, to the best of our knowledge, no case has been reported where the investigation of a cannonball pulmonary appearance led to the diagnosis of Hodgkin's lymphoma. Hence, in our case report, we attempt to highlight the uncommon presentation of this disease in a 14-year-old girl who initially presented with dyspnea before her chest x-ray revealed a cannonball pulmonary appearance, which was later linked with Hodgkin's lymphoma after performing a biopsy of her axillary node. Read More

View Article and Full-Text PDF

Massive Calcification of the Ascending Aorta Secondary to Irradiation for Hodgkin's Disease Decades Earlier in Association with Aortic Valve Stenosis.

Am J Cardiol 2022 Jul 21;175:170-174. Epub 2022 May 21.

Baylor Scott & White Heart and Vascular Institute, Baylor University Medical Center, Baylor Scott & White Health, Dallas, Texas.

Described herein are findings in 2 men who developed massively calcified non-dilated ascending aortas decades after receiving mediastinal irradiation for treatment of Hodgkin's disease associated with aortic valve stenosis. The quantity of the intimal aortic calcium was remarkable and much greater than in other aortic conditions. The ascending aorta had to be excised in one patient in order to replace the stenotic aortic valve. Read More

View Article and Full-Text PDF

First-Time Diagnosis and Ultrasound Features of Extranodal Lymphoma in Children.

J Oncol 2022 12;2022:4229112. Epub 2022 May 12.

Department of Ultrasound, Xi'an Children Hospital, Xi'an 710003, Shaanxi Province, China.

Objective: To assess the diagnostic value of ultrasound for extranodal lymphoma in children.

Methods: In this retrospective study, the first diagnostic clinical manifestation, ultrasound sonograms, and puncture pathology of 40 cases of pediatric lymphoma treated in Xi'an Children's Hospital from August 2018 to March 2020 were analyzed.

Results: The first diagnostic clinical manifestation varied from jaundice to gastrointestinal, motor, neurological, respiratory, circulatory skin, and soft tissue multisystem disorders. Read More

View Article and Full-Text PDF

Otalgia and Facial Nerve Palsy: Common Symptoms Revealing the Uncommon Pathology of Middle Ear Lymphoma.

Cureus 2022 May 15;14(5):e25023. Epub 2022 May 15.

Otolaryngology - Head and Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

Lymphoma of the middle ear and mastoid is uncommon and is rarely diagnosed early. The clinical presentation occurs due to consequences of extensive progressive disease. It can manifest as benign middle ear pathologies such as otitis media; other presentations include facial nerve palsy, hearing loss, and vestibular dysfunction. Read More

View Article and Full-Text PDF

Symptomatic ovarian involvement as the initial presentation of primary mediastinal large b-cell lymphoma.

Gynecol Oncol Rep 2022 Jun 30;41:100988. Epub 2022 Apr 30.

Department of Haematology and Bone Marrow Transplantation, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, Greece.

Primary mediastinal large B- cell lymphoma (PMLBCL) is a mature aggressive B-cell lymphoma which affects mainly young and middle-aged women. The majority of patients present with bulky mediastinal lymphadenopathy. Extranodal involvement is a rare phenomenon at disease presentation. Read More

View Article and Full-Text PDF

Radiation-induced coronary artery disease: a difficult clinical conundrum.

Clin Med (Lond) 2022 05;22(3):251-256

Royal Free Hospital, London, UK.

Accelerated coronary artery disease seen following radiation exposure is termed 'radiation-induced coronary artery disease' (RICAD) and results from both the direct and indirect effects of radiation exposure. Long-term data are available from survivors of nuclear explosions and accidents, nuclear workers as well as from radiotherapy patients. The last group is, by far, the biggest cause of RICAD presentation. Read More

View Article and Full-Text PDF

Cytologic manifestations of Hodgkin lymphoma in serous effusions.

Diagn Cytopathol 2022 May 17. Epub 2022 May 17.

Cytology Unit, Dubai Hospital, Dubai, United Arab Emirates.

Serous effusions occur in a small group of patients with classic Hodgkin lymphoma (cHL). Most effusions are benign inflammatory fluids. Malignant effusions predominantly in patients with treated relapsed diseases or rarely as a primary manifestation are diagnostically challenging to cytopathologists. Read More

View Article and Full-Text PDF

Tamponade with recurrent chylopericardium in patient with non-Hodgkin's lymphoma: chemotherapy is the key management after pericardiocentesis.

BMJ Case Rep 2022 May 17;15(5). Epub 2022 May 17.

Department of Cardiology and Vascular Medicine, Universitas Airlangga Hospital, Surabaya, East Java, Indonesia.

Cardiac tamponade, the accumulation of fluid in the pericardial space, leads to impaired venous return, loss of left ventricular preload and haemodynamic collapse. Chylopericardium is an unusual cause of the pericardial effusion. This is often secondary to malignancy. Read More

View Article and Full-Text PDF

Primary Mediastinal Large B-Cell Lymphoma Achieved by Non-Cautery Assisted Transbronchial Mediastinal Cryobiopsy.

Respiration 2022 May 16:1-5. Epub 2022 May 16.

Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China.

Transbronchial mediastinal cryobiopsy is a novel sampling strategy that shows improved diagnostic utility for mediastinal lesions, particularly in rare tumors and benign disorders, as compared to standard endobronchial ultrasound-guided transbronchial needle aspiration. During this procedure, electrocautery incision is frequently needed to advance the cryoprobe through the airway into the mediastinal lesion, which however results in increased operative difficulty and prolonged procedural time. Here we present a case of mediastinal large B-cell lymphoma successfully diagnosed by transbronchial mediastinal cryobiopsy without cautery-induced airway incision. Read More

View Article and Full-Text PDF

Site-Specific Survival of Extra Nodal Diffuse Large B-Cell Lymphoma and Comparison With Gastrointestinal Diffuse Large B-Cell Lymphoma.

J Hematol 2022 Apr 22;11(2):45-54. Epub 2022 Apr 22.

Department of Hematology and Oncology, Jersey Shore University Medical Center, Neptune, NJ, USA.

Background: Diffuse large B-cell lymphoma (DLBCL) constitutes 30% of all non-Hodgkin's lymphomas. It can present as a nodal disease or as an extra nodal disease. Based on the site of origin, extra nodal DLBCL (EN-DLBCL) may have a distinct clinical outcome. Read More

View Article and Full-Text PDF

Recurrent Syncope in a Case with Mediastinal Lymphoma.

Int Heart J 2022 May 14;63(3):647-650. Epub 2022 May 14.

Department of Cardiovascular Medicine, Kumamoto University School of Medicine.

An 83-year-old man suddenly lost consciousness, and his blood pressure dropped. Results of blood analysis were within normal range. A chest radiograph showed enlargement of the left mediastinum. Read More

View Article and Full-Text PDF