5,844 results match your criteria Lymphoma Mediastinal


Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1-ALK fusion: a case report.

Invest New Drugs 2019 Feb 21. Epub 2019 Feb 21.

Department of Clinical Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681, Japan.

An inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm that typically develops in the lungs and seldom in the head and neck region. It is often related to the anaplastic lymphoma kinase (ALK) fusion gene. Crizotinib, a first-generation ALK inhibitor, has been shown to have a notable response in patients with ALK-positive IMT. Read More

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http://dx.doi.org/10.1007/s10637-019-00742-2DOI Listing
February 2019

Ibrutinib Caused Mediastinal Emphysema and Pneumothorax in the Treatment of a Patient with Mantle Cell Lymphoma.

Drug Saf Case Rep 2019 Feb 21;6(1). Epub 2019 Feb 21.

Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

A 70-year-old Japanese man with mantle cell lymphoma underwent extensive chemotherapy and radiation because of the relapse of mantle cell lymphoma. He developed mediastinal emphysema and a pneumothorax 14 days after treatment with 560 mg of ibrutinib. The mediastinal emphysema and the right pneumothorax disappeared after the ibrutinib treatment was tapered off. Read More

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http://dx.doi.org/10.1007/s40800-019-0098-3DOI Listing
February 2019

Can we differentiate malignant peripheral nerve sheath tumor from benign neurofibroma without invasive sampling.

World J Nucl Med 2019 Jan-Mar;18(1):66-68

Department of Nuclear Medicine, Elazig Medical Park Hospital, Elazığ, Turkey.

One of the most important benign tumors in neurofibromatosis type 1 (NF1) is plexiform neurofibroma, and there is a risk of developing malignant peripheral nerve sheath tumor (MPNST) throughout life approximately 10%. However lesion characterization by anatomical imaging methods are not possible. Because of that most of cases goes to biopsy. Read More

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http://dx.doi.org/10.4103/wjnm.WJNM_11_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357707PMC
February 2019

Imaging features of SMARCA4-deficient thoracic sarcomas: a multi-centric study of 21 patients.

Eur Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Institut Bergonié, Comprehensive Cancer Center, 229, cours de l'Argonne, F-33000, Bordeaux, France.

Objectives: SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently identified aggressive subtype of sarcoma. The aim of this study was to characterize the CT imaging features of SMARCA4-DTS.

Methods: From June 2011 to May 2017, 21 adult patients with histologically proven SMARCA4-DTS were identified in the radiological database of 2 French sarcoma reference centers with at least one chest CT scan available. Read More

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http://dx.doi.org/10.1007/s00330-019-06017-xDOI Listing
February 2019
2 Reads

Biology and therapy of primary mediastinal B-cell lymphoma: current status and future directions.

Br J Haematol 2019 Feb 10. Epub 2019 Feb 10.

Blood Cancer Research Group, Mater Research, University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.

Primary mediastinal B-cell lymphoma (PMBCL) is a distinct disease closely related to classical nodular sclerosing Hodgkin lymphoma. Conventional diagnostic paradigms utilising clinical, morphological and immunophenotypical features can be challenging due to overlapping features with other B-cell lymphomas. Reliable diagnostic and prognostic biomarkers that are applicable to the conventional diagnostic laboratory are largely lacking. Read More

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http://dx.doi.org/10.1111/bjh.15778DOI Listing
February 2019
1 Read

The optimal chemotherapy regimen for primary mediastinal B-cell lymphoma: we may never know.

Authors:
Peter Martin

Leuk Lymphoma 2019 Feb 8:1-2. Epub 2019 Feb 8.

a Department of Medicine , Weil Cornell Medicine , New York , NY , USA.

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http://dx.doi.org/10.1080/10428194.2018.1535119DOI Listing
February 2019
2 Reads

[Ring-shaped lesions on a lung scan].

Ned Tijdschr Geneeskd 2019 Jan 30;163. Epub 2019 Jan 30.

Radboudumc, afd. Hematologie, Nijmegen.

A 25-year-old man was treated with pembrolizumab for a relapsed-refractory primary mediastinal large B-cell lymphoma. On an evaluation PET-CT scan multiple 'reversed halo signs' were noticed. No infectious cause was established and we diagnosed the lesions as pembrolizumab-induced pneumonitis, an immune-related adverse event. Read More

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January 2019
2 Reads

A PET Radiomics Model to Predict Refractory Mediastinal Hodgkin Lymphoma.

Sci Rep 2019 Feb 4;9(1):1322. Epub 2019 Feb 4.

Department of Radiation Oncology, Division of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.

First-order radiomic features, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), are associated with disease progression in early-stage classical Hodgkin lymphoma (HL). We hypothesized that a model incorporating first- and second-order radiomic features would more accurately predict outcome than MTV or TLG alone. We assessed whether radiomic features extracted from baseline PET scans predicted relapsed or refractory disease status in a cohort of 251 patients with stage I-II HL who were managed at a tertiary cancer center. Read More

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http://www.nature.com/articles/s41598-018-37197-z
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http://dx.doi.org/10.1038/s41598-018-37197-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361903PMC
February 2019
2 Reads
5.078 Impact Factor

Primary central nervous system Hodgkin Lymphoma: A case discussion and a hypothesis on the etiology.

Avicenna J Med 2019 Jan-Mar;9(1):28-31

Hematogenix Laboratory Services, Tinley Park, IL, USA.

Hodgkin Lymphoma (HL) is a systemic disease with involvement of the cervical, supraclavicular, and mediastinal lymph nodes. It is commonly diagnosed in patients within the second and third decades of their lives. Diagnosis is usually made based on the distinct morphological and immunohistochemical characteristics, with the tissue biopsy being the cornerstone of workup. Read More

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http://www.avicennajmed.com/preprintarticle.asp?id=240257
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http://dx.doi.org/10.4103/ajm.AJM_104_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335883PMC
January 2019
5 Reads

Feline Lymphoma and a High Correlation with Feline Leukaemia Virus Infection in Brazil.

J Comp Pathol 2019 Jan 29;166:20-28. Epub 2018 Nov 29.

Laboratory of Animal Pathology, Agroveterinary Sciences Center, Brazil. Electronic address:

Lymphoma is the most important haemopoietic tumour in cats and has been associated with feline leukaemia virus (FeLV) infection. In Brazil, no studies have established a correlation between FeLV infection and lymphoma. The aim of this study was to characterize lymphomas arising in cats in Brazil anatomically and microscopically, and to correlate these data with FeLV infection as determined by immunohistochemistry for the FeLV gp70 antigen. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.10.171DOI Listing
January 2019
1 Read

Cutaneous involvement as the first manifestation of T-lymphoblastic lymphoma and review of the literature.

J Cutan Pathol 2019 Jan 24. Epub 2019 Jan 24.

Department of Pathology, Hospital Universitario de La Princesa, Madrid, Spain.

Lymphoblastic lymphomas (LBL) are uncommon malignant neoplasms derived from immature T- or B- lymphoid progenitor cells. Although cutaneous involvement may reach 33% in B-LBL, only twelve cutaneous cases of T- LBL have been published. We report the case of a 49-year-old woman with 2-month history of erythematous-violaceous plaques in the sternal region and breasts. Read More

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http://dx.doi.org/10.1111/cup.13431DOI Listing
January 2019
1 Read

Spontaneous Regression of Clinically Indolent Lymphomas Revealed by 18F-FDG PET/CT.

Clin Nucl Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.

A 48-year-old man and a 55-year-old woman, who were diagnosed with follicular lymphoma and small B lymphocytic cell lymphoma, respectively, underwent initial "watch-and-wait" approach against lymphoma. The initial F-FDG PET/CT of both patients showed multiple FDG-avid lymph nodes in the neck, mediastinum, abdomen, and inguinal regions. During their active surveillance, the follow-up PET/CT of both patients revealed spontaneous regression of lymphoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002457DOI Listing
January 2019
3 Reads

Parapharyngeal Ganglioneuroma Detected by 18F-FDG PET/CT in a Patient With Hodgkin Lymphoma.

Clin Nucl Med 2019 Mar;44(3):240-243

Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan.

A 38-year-old woman with anterior mediastinal Hodgkin lymphoma underwent F-FDG PET/CT, revealing abnormal uptake at the left retrostyloid parapharyngeal space. After chemotherapy, follow-up PET/CT showed regression of previously avid lesions but not the left retropharyngeal mass. Subsequent MRI revealed findings suggestive of neurogenic tumor. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002444DOI Listing
March 2019
3 Reads

PET-adapted treatment for newly diagnosed advanced Hodgkin lymphoma (AHL2011): a randomised, multicentre, non-inferiority, phase 3 study.

Lancet Oncol 2019 Feb 15;20(2):202-215. Epub 2019 Jan 15.

LYSA Imaging, Hôpital H Mondor, Creteil, France.

Background: Increased-dose bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) improves progression-free survival in patients with advanced Hodgkin lymphoma compared with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD), but is associated with increased risks of haematological toxicity, secondary myelodysplasia or leukaemia, and infertility. We investigated whether PET monitoring during treatment could allow dose de-escalation by switching regimen (BEACOPP to ABVD) in early responders without loss of disease control compared with standard treatment without PET monitoring.

Methods: AHL2011 is a randomised, non-inferiority, phase 3 study done in 90 centres across Belgium and France. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30784-8DOI Listing
February 2019
4 Reads
24.690 Impact Factor

R-CHOP without radiation in frontline management of primary mediastinal B-cell lymphoma.

Leuk Lymphoma 2019 Jan 18:1-5. Epub 2019 Jan 18.

a Department of Oncology , Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine , Baltimore , MD , USA.

Prior to the introduction of rituximab, primary mediastinal B-cell lymphoma (PMBCL) had high rates of treatment failure with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), prompting the use of consolidative mediastinal radiation or more intensive chemotherapy regimens. Cure rates improved dramatically with rituximab, but mediastinal radiation was still commonly employed with R-CHOP. We performed a retrospective review of patients treated with R-CHOP alone without radiation for PMBCL. Read More

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http://dx.doi.org/10.1080/10428194.2018.1519812DOI Listing
January 2019
5 Reads

ROS1-rearranged high-PD-L1-expressing lung adenocarcinoma manifesting as mediastinal tumor: A case report.

Oncol Lett 2019 Jan 25;17(1):488-491. Epub 2018 Oct 25.

Division of Thoracic Surgery, Graduate School of Medicine, Kobe University, Kobe, Hyogo 650-0017, Japan.

ROS proto-oncogene 1 receptor tyrosine kinase (ROS1)-rearranged lung cancer is rare and comprises only 1% of lung adenocarcinoma cases. It has recently been reported to have good response to crizotinib, a tyrosine kinase inhibitor of anaplastic lymphoma kinase. Driver oncogene mutations with approved therapies seldom coexist with a high expression of Programmed death-ligand 1 (PD-L1). Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9622
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http://dx.doi.org/10.3892/ol.2018.9622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313173PMC
January 2019
6 Reads

Mediastinal follicular dendritic cell sarcoma: a rare, potentially under-recognized, and often misdiagnosed disease.

Diagn Pathol 2019 Jan 15;14(1). Epub 2019 Jan 15.

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Background: Mediastinal follicular dendritic cell sarcoma (FDCS) is extremely rare. Due to potential under-recognization of this disease, it happens to be misdiagnosed, especially on core needle biopsy. We report 3 cases of mediastinal FDCS and provide a literature review to improve better understanding of the tumor and to reduce misdiagnosis. Read More

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http://dx.doi.org/10.1186/s13000-019-0779-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334468PMC
January 2019
2 Reads

Six-year-old boy with mediastinal mass.

J Pak Med Assoc 2019 Jan;69(1):135

Department of Pediatric Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Lymphoblastic lymphomas account for 20-30% of all non-Hodgkin lymphomas (NHL) in children, and most cases of childhood lymphoblastic lymphoma are T-cell type (T-LL). T-LL occurs most frequently in late childhood and adolescence; with male predominance of 2:1.We present a paediatric case with a right sided mediastinal mass causing mediastinal shift diagnosed as T-LL. Read More

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January 2019
3 Reads

Predictive Factors for Inaccurate Diagnosis of Swollen Lymph Nodes in Endoscopic Ultrasound-Guided Fine Needle Aspiration.

Clin Endosc 2019 Jan 7. Epub 2019 Jan 7.

Department of Gastroenterology, Sendai City Medical Center, Sendai, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.

Background/aims: This study aimed to identify the predictive factors for inaccurate endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) diagnosis of swollen lymph nodes without rapid on-site cytopathological evaluation.

Methods: Eighty-three consecutive patients who underwent EUS-FNA for abdominal or mediastinal lymph nodes from January 2008 to June 2017 were included from a prospectively maintained EUS-FNA database and retrospectively reviewed. The sensitivity, specificity, and accuracy of EUS-FNA for the detection of neoplastic diseases were calculated. Read More

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http://dx.doi.org/10.5946/ce.2018.125DOI Listing
January 2019
1 Read

Six versus eight doses of rituximab in patients with aggressive B cell lymphoma receiving six cycles of CHOP: results from the "Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas" (PETAL) trial.

Ann Hematol 2019 Jan 4. Epub 2019 Jan 4.

Klinik für Hämatologie, Universitätsklinikum Essen, Essen, Germany.

Standard first-line treatment of aggressive B cell lymphoma comprises six or eight cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus eight doses of rituximab (R). Whether adding two doses of rituximab to six cycles of R-CHOP is of therapeutic benefit has not been systematically investigated. The Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL) trial investigated the ability of [F]-fluorodesoxyglucose PET scanning to guide treatment in aggressive non-Hodgkin lymphomas. Read More

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http://dx.doi.org/10.1007/s00277-018-3578-0DOI Listing
January 2019
3 Reads

The management of primary mediastinal B-cell lymphoma: a British Society for Haematology Good Practice Paper.

Br J Haematol 2019 Jan 4. Epub 2019 Jan 4.

Department of Medical Oncology, Southampton General Hospital, Southampton, UK.

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http://dx.doi.org/10.1111/bjh.15731DOI Listing
January 2019
2 Reads

Secondary Thymoma among Adult Treated For Acute Lymphoblastic Lymphoma/Leukemia: Report of a Case and Review of the Literature.

Open Access Maced J Med Sci 2018 Dec 14;6(12):2373-2375. Epub 2018 Dec 14.

Hematology and Pediatric Oncology Center, Hospital 20 Aout Pediatric, Casablanca, Morocco.

Background: Concomitant thymoma and T- lymphoblastic/leukaemia lymphoma is possible. Secondary thymoma after treatment for T-lymphoblastic/leukaemia lymphoma was also occasionally reported, although this is quite rare.

Case Report: We report a case of 44-year-old women with secondary thymoma after chemotherapy treatment for T Acute Lymphoblastic leukaemia/lymphoma. Read More

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http://dx.doi.org/10.3889/oamjms.2018.396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311490PMC
December 2018
2 Reads

Crazy paving pattern as a rare radiological manifestation of peripheral T-cell lymphoma (PTCL) with lung involvement: A case report.

Respir Med Case Rep 2018 26;25:253-256. Epub 2018 Sep 26.

3rd Department of Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

We report on a 70-year old woman with dyspnea, systemic lymphadenopathy and abnormal chest computed tomography (CT) findings. A complete laboratory testing as well as mediastinal tissue sampling via Endobronchial Ultrasound (EBUS)-guided Transbronchial Needle Biopsy (TBNB) did not reveal a definite diagnosis. After experiencing acute respiratory failure which led to intensive care unit, the patient underwent a cervical lymph node biopsy which revealed peripheral T-cell lymphoma not otherwise specified (PTCL-NOS). Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308371PMC
September 2018
2 Reads

Dyspnea in Pregnancy: A Case Report of a Third Trimester Mediastinal Mass in Pregnancy.

Am J Case Rep 2018 Dec 28;19:1536-1540. Epub 2018 Dec 28.

Department of Obstetrics, University of Tennessee, Knoxville, TN, USA.

BACKGROUND Dyspnea in pregnancy is common and attributable to a variety of etiologies including normal physiology. The obstetric provider is challenged with distinguishing between physiologic versus pathologic dyspnea. CASE REPORT A 31-year-old G2 P1001 female at 34 weeks gestation presented with dyspnea, tachycardia, and inability to lie supine. Read More

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http://dx.doi.org/10.12659/AJCR.910725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322058PMC
December 2018
2 Reads

Retrospective Analysis of 9 Cases of Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma and Literature Review.

Med Sci Monit Basic Res 2018 Dec 24;24:233-240. Epub 2018 Dec 24.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland).

BACKGROUND Primary pulmonary mucosa-associated lymphoma tissue lymphoma is rare and is often misdiagnosed because of its diverse and nonspecific clinical features. The aim of this study was to raise awareness among clinicians and to share our experience of treating and managing such patients. MATERIAL AND METHODS This retrospective study was conducted between 1 January 2009 and 31 October 2017 at the First Affiliated Hospital of Guangxi Medical University. Read More

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http://dx.doi.org/10.12659/MSMBR.912762DOI Listing
December 2018
2 Reads

I-MIBG for detection of subacute doxorubicin-induced cardiotoxicity in patients with malignant lymphoma.

J Nucl Cardiol 2018 Dec 19. Epub 2018 Dec 19.

Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Doxorubicin is the mainstay of curative lymphoma treatment but is associated with a dose-dependent cardiotoxicity that is often recognized too late to avoid substantial irreversible cardiac injury. Iodine-123 metaiodobenzylguanidine (I-MIBG) is a gamma-emitting tracer that mimics noradrenaline uptake, storage, and release mechanisms in adrenergic presynaptic neurons. I-MIBG scintigraphy can be used for assessment of doxorubicin-induced injury to myocardial adrenergic neurons during treatment and could be the tool for early detection of doxorubicin cardiotoxicity, which is currently lacking. Read More

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http://dx.doi.org/10.1007/s12350-018-01566-yDOI Listing
December 2018
3 Reads

Comparison of F FDG PET-CT AND CECT in pretreatment staging of adults with Hodgkin's lymphoma.

Leuk Res 2019 Jan 5;76:48-52. Epub 2018 Dec 5.

Hematology, Department of Translation and Precision Medicine, "Sapienza" University of Rome, Italy; Hematology Unit, S. Maria Goretti Hospital, AUSL Latina, Italy. Electronic address:

We compared 2-[fluorine-18] fluoro-2-deoxy-d-glucose PET-CT and contrast-enhanced computed tomography (CECT) in 62 consecutive patients with newly diagnosed Hodgkin Lymphoma (HL), aiming to provide evidences that may spare CECT from the staging procedures of HL patients. Among a total of 1448 nodal sites examined, disease involvement was detected in 232 (16%) and 280 (19.3%) nodal areas by CECT and PET-CT, respectively (P < 0. Read More

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http://dx.doi.org/10.1016/j.leukres.2018.11.018DOI Listing
January 2019
2 Reads

Gadolinium-enhanced imaging of pediatric thoracic lymphoma: is intravenous contrast really necessary?

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Germany.

Objectives: Increasing awareness of potential side effects from gadolinium-based contrast agents has underlined the need for contrast-free magnetic resonance imaging (MRI). Numerous recent articles evaluated the risk of potential brain deposits, with the result that research is putting the focus more on alternative unenhanced imaging techniques. The aim of this study was to determine the need for contrast media for chest MRI in primary staging and follow-up care of lymphoma. Read More

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http://link.springer.com/10.1007/s00330-018-5859-3
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http://dx.doi.org/10.1007/s00330-018-5859-3DOI Listing
December 2018
10 Reads

Reversal of resistance to chemotherapy following anti-programmed cell death-1 immunotherapy in metastatic lung adenocarcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13427

Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China.

Rationale: For metastatic non-small cell lung cancer with no epidermal growth factor receptor mutations or anaplastic lymphoma kinase gene rearrangements, programmed cell death-1 (PD-1) blockade is preferentially recommended post first-line chemotherapy. However, still many patients do not respond to these agents. After development of resistance to PD-1 blockade, further evaluation of chemotherapy regimen will be necessary. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812070-0005
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http://dx.doi.org/10.1097/MD.0000000000013427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310537PMC
December 2018
8 Reads

Use of Fludarabine for the Treatment of Indolent Lymphoma with Chylothorax.

Klin Onkol 2018 ;31(4):301-304

Background: Although chylothorax is rare in patients with malignant lymphoma, it has been reported in cases with mediastinal lymphadenopathy, a bulky retroperitoneal mass, or thoracic ducts blocked by lymphocytes in chronic lymphocytic leukemia (CLL). The clinical picture is not specific. Patients become more immunocompromised and malnourished after repeated evacuations. Read More

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http://dx.doi.org/10.14735/amko2018301DOI Listing
January 2018
3 Reads

Gray-zone Lymphoma Between cHL and Large B-Cell Lymphoma: A Histopathologic Series From the LYSA.

Am J Surg Pathol 2019 Mar;43(3):341-351

INSERM1052, CNRS 5286, Lyon-Sud Charles Mérieux Lyon-1 Faculty, Claude Bernard University.

Gray-zone lymphoma (GZL) with features intermediate between classic Hodgkin lymphoma (cHL) and large B-cell lymphoma (LBCL) was introduced as a provisional entity into the World Health Organization classification in 2008. However, as diagnostic criteria are imprecise, reliable identification of GZL cases remains challenging. Here, we describe the histopathologic features of 139 GZL cases from a retrospective Lymphoma Study Association (LYSA) study with the goal to improve classification accuracy. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001198DOI Listing
March 2019
12 Reads

Successful Localization Using Ga-DOTATOC PET/CT of a Phosphaturic Mesenchymal Tumor Causing Osteomalacia in a Patient with Concurrent Follicular Lymphoma.

Nucl Med Mol Imaging 2018 Dec 12;52(6):462-467. Epub 2018 Sep 12.

1Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505 South Korea.

Diagnosing tumor-induced osteomalacia is often challenging because conventional imaging modalities may fail to locate the responsible tumor. This report describes the ability of Ga-DOTATOC PET/CT to successfully distinguish between the responsible phosphaturic mesenchymal tumor and concurrent lymphoma lesions. A 52-year-old man with bone pain for several years was diagnosed with a vitamin D-resistant hypophosphatemic osteomalacia. Read More

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http://link.springer.com/10.1007/s13139-018-0546-5
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http://dx.doi.org/10.1007/s13139-018-0546-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261860PMC
December 2018
6 Reads

Predictors for reactive thymic hyperplasia and its prognostic value in children and adolescents with lymphoma.

Eur J Radiol 2018 Dec 5;109:108-113. Epub 2018 Oct 5.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Department of Nuclear Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. Electronic address:

Background: Reactive thymic hyperplasia (RTH) is seen in children and adolescents receiving chemotherapy for various malignancies. However, it is not clear why this occurs only in some patients. The aim of this study was to identify the predictors for RTH in children and adolescents receiving chemotherapy for lymphoma and to determine the effect of RTH on prognosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183035
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http://dx.doi.org/10.1016/j.ejrad.2018.10.004DOI Listing
December 2018
13 Reads

Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.

Lancet Oncol 2019 Jan 2;20(1):31-42. Epub 2018 Dec 2.

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Axicabtagene ciloleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. In the previous analysis of the ZUMA-1 registrational study, with a median follow-up of 15·4 months (IQR 13·7-17·3), 89 (82%) of 108 assessable patients with refractory large B-cell lymphoma treated with axicabtagene ciloleucel achieved an objective response, and complete responses were noted in 63 (58%) patients. Here we report long-term activity and safety outcomes of the ZUMA-1 study. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30864-7DOI Listing
January 2019
11 Reads
24.690 Impact Factor

Value of CT spectral imaging in the differential diagnosis of thymoma and mediastinal lymphoma.

Br J Radiol 2019 Mar 3;92(1095):20180598. Epub 2018 Dec 3.

1 Department of Radiology, Lanzhou University Second Hospital , Lanzhou , PR China.

Objective:: To investigate the imaging characteristics of thymoma and mediastinal lymphoma using spectral CT and evaluate whether the quantitative information can improve the differential diagnosis of these diseases.

Methods:: This retrospective study was approved by the institutional review board, and written informed consent was obtained from all patients. Overall, 39 patients with mediastinal tumors (24 thymomas and 15 mediastinal lymphomas) were examined with CT spectral imaging during the arterial phase (AP) and venous phase (VP). Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180598
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http://dx.doi.org/10.1259/bjr.20180598DOI Listing
March 2019
3 Reads

Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia.

Case Rep Hematol 2018 30;2018:6154709. Epub 2018 Oct 30.

Department of Hematology/Oncology, Joan C. Edwards School of Medicine Marshall University, 1600 Medical Center Dr, Huntington, WV 25701, USA.

Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is a hematologic malignancy characterized by an over accumulation of incompetent neoplastic lymphocytes. Bone metastasis in CLL/SLL is very rare. We report a case of a 76-year-old Caucasian female presented with an unresolving pulmonary infiltrate with mediastinal lymphadenopathy concerning for malignancy. Read More

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http://dx.doi.org/10.1155/2018/6154709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232806PMC
October 2018
4 Reads

Is SUVmax Helpful in the Differential Diagnosis of Enlarged Mediastinal Lymph Nodes? A Pilot Study.

Contrast Media Mol Imaging 2018 28;2018:3417190. Epub 2018 Oct 28.

Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Objective: To explore the diagnostic value of maximum standard uptake value (SUVmax) from F-FDG PET/CT images in enlarged mediastinal lymph nodes of unknown etiology.

Methods: We performed a retrospective study of patients with enlarged mediastinal lymph nodes on F-FDG PET/CT scans. SUVmax and the short axis and long axis of lymph nodes were recorded. Read More

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http://dx.doi.org/10.1155/2018/3417190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230427PMC
October 2018
3 Reads

Role of consolidative radiation therapy for patients with mediastinal diffuse large B-cell lymphoma in the rituximab era.

J Cancer Res Ther 2018 Oct-Dec;14(6):1397-1402

Department of Radiation Oncology, Ege University Medical Faculty, Izmir, Turkey.

Background: The most common subtype of aggressive non-Hodgkin Lymphomas is diffuse large B-cell lymphoma (DLBCL). Mediastinal DLBCL is a distinct entity with unique clinical, pathologic, and genetic features and accepted as a subtype of DLBCL. The aim of this study is to evaluate the patients treated with consolidative radiotherapy (RT) after rituximab-containing chemotherapy for mediastinal DLBCL regarding treatment outcomes and relapse patterns. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_3_17DOI Listing
February 2019
3 Reads

Dosimetric comparison of anterior posterior-posterior anterior 2-field three-dimensional conformal radiotherapy, 4-field three-dimensional conformal radiotherapy and "forward" plan intensity modulated radiotherapy techniques in female lymphoma patients irradiated to neck and mediastinum.

J Cancer Res Ther 2018 Oct-Dec;14(6):1389-1396

Department of Radiation Oncology, Dokuz Eylül University Medical Faculty, Izmir, Turkey.

Aim: Dosimetric comparison of three different techniques in female lymphoma patients who had radiotherapy (RT) to the neck and mediastinum.

Setting And Design: Retrospective clinical study.

Materials And Methods: Computerized tomography-simulator images of eight patients were obtained retrospectively. Read More

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http://dx.doi.org/10.4103/0973-1482.193108DOI Listing
February 2019
4 Reads

Unusual behavior of diffuse large B-cell lymphoma as cardiac invasion with rapid spontaneous regression after fine needle aspiration cytology.

J Exp Ther Oncol 2018 Nov;12(4):287-290

Cardiology Department, Mansoura Faculty of Medicine, Mansoura University, Egypt.

Objective: Spontaneous regression (SR) of lymphoma is a rare phenomenon. While the precise mechanism of SR remains unknown, apoptosis may be associated with its process. Here, we present a case of a 52-year-old woman was admitted to our hospital with cough and orthopnea for 2 weeks. Read More

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November 2018
13 Reads

Thymic inflammatory pseudotumor with multilocular thymic cyst caused by immunoglobulin G4-related disease.

Thorac Cancer 2019 Jan 23;10(1):116-119. Epub 2018 Nov 23.

Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

A 44-year-old man was referred to our hospital after an anterior mediastinal tumor was noted on computed tomography during follow-up observation after left testicular seminoma resection. Chest computed tomography revealed an enhanced mass measuring 33 x 16 x 15 mm at the anterior mediastinum. Chest magnetic resonance imaging revealed high signal intensity on T2-weighted imaging, and F  fluorodeoxyglucose-positron emission tomography showed a maximum standardized uptake of 12. Read More

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http://dx.doi.org/10.1111/1759-7714.12914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312835PMC
January 2019
16 Reads

Distinguishing thymoma from T-lymphoblastic leukaemia/lymphoma: a case-based evaluation.

J Clin Pathol 2019 Mar 22;72(3):251-257. Epub 2018 Nov 22.

Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA

T-lymphoblastic lymphoma and thymoma are distinct primary mediastinal neoplasms that can have similar clinical presentations and overlapping histological features. Microscopic distinction is occasionally difficult because the immature lymphocytes associated with thymoma may resemble T-lymphoblastic leukaemia/lymphoma cells, morphologically and immunohistochemically. An accurate diagnosis assumes particular importance since the treatment approaches for these two entities differ considerably. Read More

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http://dx.doi.org/10.1136/jclinpath-2018-205399DOI Listing
March 2019
14 Reads

Quantitative assessment of 18F-FDG PET in patients with Hodgkin lymphoma: is it significantly affected by contrast-enhanced computed tomography attenuation correction?

Nucl Med Commun 2019 Mar;40(3):249-257

Departments of Nuclear Medicine.

Objective: The reliability of visual and quantitative response assessment may be impaired owing to inconsistent scanning protocols and image reconstruction methods of 2-deoxy-2-[F]fluoro-D-glucose (F-FDG) PET. Hence, this study investigates the effect of contrast-enhanced computed tomography (CT) attenuation correction in patients with Hodgkin lymphoma.

Patients And Methods: In 10 consecutive patients undergoing either staging or response assessment, F-FDG PET images were attenuation-corrected once on the basis of unenhanced CT and additionally using contrast-enhanced CT. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000956DOI Listing
March 2019
3 Reads

[Left-sided Chylothorax and Tumor of the Right Anterior Mediastinum].

Pneumologie 2018 Dec 19;72(12):851-854. Epub 2018 Nov 19.

Thoraxchirurgische Abteilung des LungenZentrums Saar, SHG-Kliniken, Völklingen.

An 82-year-old male patient presented with a left-sided spontaneous chylothorax. A computed tomographic scan of the chest revealed a cystic tumor in the right upper anterior mediastinum and nodules in the left mediastinum that we interpreted as enlarged lymph nodes. On suspicion of lymphoma and for therapy of chylothorax, we performed a left-sided thoracotomy. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0767-7882
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http://dx.doi.org/10.1055/a-0767-7882DOI Listing
December 2018
9 Reads

HLA genotype and response to nivolumab therapy in relapsed refractory primary mediastinal B-cell lymphoma.

Curr Res Transl Med 2019 Feb 14;67(1):31-33. Epub 2018 Nov 14.

Division of Hematology & HSCT, Department of Oncology, King Abdulaziz Medical City, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24523186183005
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http://dx.doi.org/10.1016/j.retram.2018.11.001DOI Listing
February 2019
16 Reads

Early Changes in Cardiovascular Biomarkers with Contemporary Thoracic Radiation Therapy for Breast Cancer, Lung Cancer, and Lymphoma.

Int J Radiat Oncol Biol Phys 2019 Mar 14;103(4):851-860. Epub 2018 Nov 14.

Department of Medicine, Division of Cardiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Purpose: We characterized the early changes in cardiovascular biomarkers with contemporary thoracic radiation therapy (RT) and evaluated their associations with radiation dose-volume metrics including mean heart dose (MHD), V5, and V30.

Methods And Materials: In a prospective longitudinal study of 87 patients with breast cancer, lung cancer, or mediastinal lymphoma treated with photon or proton thoracic RT, blood samples were obtained pre-RT and after completion of RT (median, 20 days; interquartile range [IQR], 1-35). High-sensitivity cardiac troponin T, N-terminal pro-B-type natriuretic peptide, placental growth factor (PIGF), and growth differentiation factor 15 (GDF-15) were measured. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016183399
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http://dx.doi.org/10.1016/j.ijrobp.2018.11.013DOI Listing
March 2019
11 Reads
4.258 Impact Factor

Endobronchial ultrasound-guided transbronchial needle aspiration cytology in patients with known or suspected extra-pulmonary malignancies: A cytopathology-based study.

Cytopathology 2019 Jan 21;30(1):82-90. Epub 2018 Dec 21.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the primary modality for mediastinal lymph node staging in lung carcinoma. We aimed to evaluate its utility in extra-pulmonary malignancies (EPM).

Methods: Database search of EBUS-TBNA aspirations (2013-2017) done in patients with known/suspected EPMs and mediastinal lymphadenopathy/masses was performed. Read More

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http://dx.doi.org/10.1111/cyt.12656DOI Listing
January 2019
4 Reads
1.481 Impact Factor