290 results match your criteria Lymphoma Malignant Small Noncleaved


Feline Lymphoma and a High Correlation with Feline Leukaemia Virus Infection in Brazil.

J Comp Pathol 2019 Jan 29;166:20-28. Epub 2018 Nov 29.

Laboratory of Animal Pathology, Agroveterinary Sciences Center, Brazil. Electronic address:

Lymphoma is the most important haemopoietic tumour in cats and has been associated with feline leukaemia virus (FeLV) infection. In Brazil, no studies have established a correlation between FeLV infection and lymphoma. The aim of this study was to characterize lymphomas arising in cats in Brazil anatomically and microscopically, and to correlate these data with FeLV infection as determined by immunohistochemistry for the FeLV gp70 antigen. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.10.171DOI Listing
January 2019
2 Reads

Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature.

Radiat Oncol 2013 Jun 20;8:147. Epub 2013 Jun 20.

Primary cutaneous follicle center lymphoma is an indolent primary cutaneous B-cell lymphoma originating from the follicle center cells, composed of a combination of centrocytes (small and large cleaved cells) and centroblasts (large noncleaved cells) with a follicular, follicular/diffuse, or diffuse growth pattern. Lesions are mostly located on the head, neck and trunk. A case is presented of a 56-year-old male patient with primary cutaneous follicle center lymphoma, with lesions involving the skin of the back, shoulders, presternal area and right forearm. Read More

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http://dx.doi.org/10.1186/1748-717X-8-147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702489PMC
June 2013
9 Reads

Post-transplant Burkitt lymphoma is a more aggressive and distinct form of post-transplant lymphoproliferative disorder.

Cancer 2011 Oct 28;117(19):4540-50. Epub 2011 Mar 28.

Department of Pediatric Pathology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background: Although the literature reports a low incidence of Burkitt lymphoma (BL) as a post-transplant lymphoproliferative disorder (PTLD), this entity appears to be different from other monomorphic PTLDs (M-PTLDs), both in its aggressive clinical presentation and its distinct pathologic profile.

Methods: Patients with BL, diagnosed in the post-transplant setting, (patients aged ≤ 18 years) were retrieved from the pathology archives at Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center from 1982 to 2010. Clinical outcomes were obtained along with pathologic review. Read More

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http://dx.doi.org/10.1002/cncr.26001DOI Listing
October 2011
6 Reads
9 Citations
4.890 Impact Factor

Retrospective study of 82 cases of canine lymphoma in Austria based on the Working Formulation and immunophenotyping.

J Comp Pathol 2007 Feb-Apr;136(2-3):186-92

Central Laboratory, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria.

In human beings the prevalence of different non-Hodgkin's lymphoma (NHL) subtypes varies according to geographical region. The aim of this study was to classify canine lymphomas in Austria and to compare the results with those of similar studies in other countries. Eighty-two NHLs were classified according to their morphology (based on the Working Formulation) and their immunophenotype (determined with anti-T-cell and anti-B-cell antibodies). Read More

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http://dx.doi.org/10.1016/j.jcpa.2007.01.009DOI Listing
June 2007
3 Reads

The feasibility of gene expression profiling generated in fine-needle aspiration specimens from patients with follicular lymphoma and diffuse large B-cell lymphoma.

Cancer 2006 Feb;108(1):10-20

Department of Lymphoma and Myeloma, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

Lymphoma of germinal center cell (GC) origin generally is an indolent malignancy that transforms progressively into a more aggressive disease. According to the World Health Organization classification, lymphomas of follicular center cell origin are classified as either large B-cell lymphoma (LBCL) or follicular lymphoma (FL). The authors tested the feasibility of performing gene expression profiling using amplified RNA from fine-needle aspirates (FNA) obtained from lymph nodes. Read More

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http://dx.doi.org/10.1002/cncr.21500DOI Listing
February 2006
16 Reads

Human immunodeficiency virus-associated lymphoma.

Clin Adv Hematol Oncol 2003 May;1(5):295-301

Albert Einstein College of Medicine, USA.

Infection with the human immunodeficiency virus (HIV) is associated with an increased risk of systemic non-Hodgkin's lymphoma, Hodgkin's disease, and primary central nervous system lymphoma (PCNSL). Systemic lymphoma usually involves extranodal sites (80%-90%) and is usually of intermediate-grade (diffuse large-cell or immunoblastic( or high-grade (diffuse small noncleaved) histology. Approximately one third to one half of patients are cured with the cytotoxic treatment regimens that are used in immunocompetent patients with lymphoma. Read More

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May 2003
6 Reads

Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas of children and adolescents: a report from Children's Cancer Group Study CCG-E08.

J Pediatr Hematol Oncol 2004 Mar;26(3):169-78

Pathology Department, Children's Hospital of Orange County/St. Joseph Hospital, Orange, California, USA.

Among pediatric non-Hodgkin lymphomas, the most frequent type is small noncleaved-cell lymphoma (including Burkitt and Burkitt-like). Specific chromosome abnormalities are associated with prognosis in childhood acute lymphoblastic leukemia (ALL); however, chromosome abnormalities have not been evaluated for prognostic value in pediatric Burkitt and Burkitt-like lymphomas. For Children's Cancer Group protocol CCG-E-08 Etiologic Study of Non-Hodgkin Lymphoma in Childhood, 19 patients were enrolled with cytogenetic analysis of Burkitt or Burkitt-like lymphoma and simultaneously enrolled on treatment protocols CCG-503 or CCG-552. Read More

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http://pdfs.journals.lww.com/jpho-online/2004/03000/Chromoso
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March 2004
38 Reads
8 Citations

The adequacy of gross pathological examination of routine tonsils and adenoids in patients 21 years old and younger.

Hum Pathol 2003 Oct;34(10):1053-7

Department of Patholgoy, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610, USA.

Most hospitals microscopically examine all routine tonsil and adenoid specimens from healthy pediatric patients with recurrent infections or obstructive sleep apnea. Concern over missing the rare unsuspected, significant diagnosis propagates this practice. Careful gross examination for asymmetry and clinical findings should obviate the need for routine microscopic examination of tonsil and adenoid specimens in patients age 21 years and younger. Read More

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October 2003
8 Reads

Clinical perspectives of primary cardiac lymphoma.

Angiology 2003 Sep-Oct;54(5):599-604

Division of Cardiology, Long Island College Hospital, Brooklyn, NY, USA.

Primary cardiac lymphoma is a very rare malignancy, which is typically of a non-Hodgkin type, and involves only the heart and pericardium with no or minimal evidence of extracardiac involvement. Primary cardiac lymphoma account for about 1% of the primary cardiac tumors and 0.5% of the extranodal lymphomas. Read More

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http://journals.sagepub.com/doi/10.1177/000331970305400510
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http://dx.doi.org/10.1177/000331970305400510DOI Listing
November 2003
11 Reads

Burkitt's lymphoma in the base of the tongue: differential diagnosis and management.

ORL J Otorhinolaryngol Relat Spec 2003 Jul-Aug;65(4):226-9

Otorhinolaryngology Department, Ippokration Hospital, Athens University, Athens, Greece.

Burkitt's lymphoma is the most common malignancy in African children but can occur sporadically in every country. It is one of the most aggressive malignancies in the human body, and in the past the prognosis was very poor. However, complex chemotherapy regimens can now cure approximately 50-80% of adult patients with Burkitt's lymphoma or small noncleaved lymphoma, and in pediatric populations the cure rate is even higher. Read More

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http://dx.doi.org/10.1159/000073121DOI Listing
March 2004
3 Reads

Challenges in the management of Burkitt's lymphoma.

Clin Lymphoma 2002 Dec;3 Suppl 1:S19-25

Norris Cancer Hospital, University of Southern California, Los Angeles 90033-1048, USA.

Burkitt's lymphoma and small noncleaved Burkitt's-like lymphoma are rare and are highly aggressive forms of non-Hodgkin's lymphoma that are characterized by dysregulation of the c-myc oncogene. Patients with human immunodeficiency virus (HIV) also appear to be at risk for developing Burkitt's lymphomas. Treatment options for Burkitt's lymphoma involve complex chemotherapy regimens that contain as many as 10 cytotoxic agents. Read More

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December 2002
15 Reads

B-cell activation and lymphoma in patients with HIV.

Curr Opin Oncol 2002 Sep;14(5):528-32

Department of Microbiology, David Geffen School of Medicine, University of California-Los Angeles, 90095, USA.

The risk of developing non-Hodgkin lymphoma (AIDS lymphoma) is greatly increased in HIV infection. Disruption of immune function by HIV infection may contribute to lymphomagenesis by inducing (1) loss of immunoregulation of Epstein-Barr virus-infected B cells [immunoblastic and central nervous system (CNS) lymphoma] caused by loss of T-cell function, and (2) chronic B-cell hyperactivation enhancing the generation of genetic lesions (c- :immunoglobulin gene translocation, -6 overexpression) associated with some forms of AIDS lymphoma (Burkitt lymphoma-like small noncleaved cell lymphoma and large noncleaved cell lymphoma). Also, the overproduction of B-cell-stimulatory cytokines (interleukin 10 and 6) has the potential to contribute to tumor development by supporting the growth and viability of nascent lymphoma cell clones. Read More

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September 2002
2 Reads

Non-Hodgkin's lymphoma arising in bone in children and adolescents is associated with an excellent outcome: a Children's Cancer Group report.

J Clin Oncol 2002 May;20(9):2293-301

Pathology Department, Children's Hospital of Orange County/St Joseph Hospital, Orange, CA, USA.

Purpose: Non-Hodgkin's lymphoma (NHL) arising in bone is a heterogeneous histologic type of NHL that includes large-cell lymphoma, lymphoblastic lymphoma, and small noncleaved-cell lymphoma. NHL arising in bone is well recognized in adults but is less well characterized and infrequent in children and adolescents.

Patients And Methods: We performed a retrospective review of Children's Cancer Group (CCG) studies treating children and adolescents with NHL over a 20-year period (CCG-551, CCG-501, CCG-502, CCG-503, CCG-552, CCG-5911, and CCG-5941) and determined the response and event-free survival (EFS) rates in 31 patients with NHL arising in bone. Read More

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http://dx.doi.org/10.1200/JCO.2002.06.017DOI Listing
May 2002
8 Reads

Second malignancy after treatment of childhood non-Hodgkin lymphoma.

Cancer 2001 Oct;92(7):1959-66

St. Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105-2794, USA.

Background: The objective of this report was to determine the cumulative incidence of and risk factors for second malignancy and the competing risk of death due to any other cause among patients who were treated for childhood non-Hodgkin lymphoma (NHL).

Methods: The authors retrospectively reviewed a cohort of 497 patients with NHL who were treated at St. Jude Children's Research Hospital between 1970 and 1997. Read More

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October 2001
5 Reads

Treatment of high-grade lymphoid malignancies in adults.

Authors:
C A Schiffer

Semin Hematol 2001 Oct;38(4 Suppl 10):22-6

Division of Hematology/Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.

High-grade, B-lineage lymphoproliferative disorders can have a leukemic (acute lymphocytic leukemia [ALL] French-American-British [FAB] stage L-3), a lymphomatous (Burkitt's or small noncleaved [SNC]), or often a mixed clinical presentation in adults. Manifestations of these diseases in both adults and children include a propensity for abdominal and CNS involvement and a high incidence of metabolic abnormalities due to rapid cell growth and turnover, which are acutely exacerbated by treatment. Numerous studies show that FAB L-3, Burkitt's lymphoma (BL), and SNC are among the most curable of the multiple leukemia/lymphoma subtypes if treated appropriately. Read More

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October 2001
5 Reads

Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251.

J Clin Oncol 2001 Oct;19(20):4014-22

Department of Medicine, the Alvin and Lois Lapidus Cancer Institute, Sinai Hospital, Baltimore, MD, USA.

Purpose: To define the activity and feasibility of brief-duration high-intensity chemotherapy for adults with small noncleaved, non-Hodgkin's lymphoma (SNC) and the L3 variant of acute lymphocytic leukemia (L3 ALL).

Patients And Methods: Seventy-five adults with either SNC or L3 ALL (median age, 44 years) were treated with an aggressive regimen that consisted of one cycle of cyclophosphamide and prednisone followed by cycles containing either ifosfamide or cyclophosphamide; high-dose methotrexate, vincristine, dexamethasone, and either doxorubicin or etoposide/cytarabine; or intrathecal triple therapy with prophylactic CNS irradiation.

Results: All 24 patients with L3 ALL and the 30 of 51 patients with SNC confirmed by central histologic review were included in this analysis. Read More

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http://dx.doi.org/10.1200/JCO.2001.19.20.4014DOI Listing
October 2001
5 Reads

Clinical, immunologic, and pathologic correlates of bone marrow involvement in 291 patients with acquired immunodeficiency syndrome-related lymphoma.

Blood 2001 Oct;98(8):2358-63

Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA.

Bone marrow involvement is reported in approximately 25% of patients with newly diagnosed acquired immunodeficiency syndrome-related lymphoma (ARL). Studied were 291 patients with ARL, diagnosed and treated at one medical center between 1984 and 1998. Clinical, immunologic, and pathologic characteristics of patients with bone marrow involvement were compared with those of patients without marrow involvement. Read More

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October 2001
9 Reads

Evolving characteristics of AIDS-related lymphoma.

Blood 2000 Dec;96(13):4084-90

Division of Hematology, Department of Medicine, and Division of Hematopathology, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Over time, the epidemiologic and demographic characteristics of AIDS have changed in the United States, while the use of highly active antiretroviral therapy has changed the natural history of the disease. The goal of the study was to ascertain any changes in the epidemiologic, immunologic, pathologic, or clinical characteristics of AIDS-related lymphoma (ARL) over the course of the AIDS epidemic. Records of 369 patients with ARL diagnosed or treated at a single institution from 1982 through 1998 were reviewed. Read More

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December 2000
6 Reads

Toxicity of high-dose sequential chemotherapy and purged autologous hematopoietic cell transplantation precludes its use in refractory/recurrent non-Hodgkin's lymphoma.

Biol Blood Marrow Transplant 2000 ;6(5A):555-62

Division of Bone Marrow Transplantation, Stanford University, California 94305, USA.

We conducted a pilot study in 20 patients with high-risk or recurrent/refractory non-Hodgkin's lymphoma (NHL) using high-dose sequential chemotherapy (HDSC) and autologous hematopoietic cell transplantation (AHCT). After cytoreduction with standard salvage therapy, HDSC/AHCT was administered in 4 phases at 2- to 4-week intervals. Phase 1 consisted of cyclophosphamide 7 g/m2 followed by granulocyte colony-stimulating factor (G-CSF) at 10 microg/kg per day and leukapheresis upon recovery from white blood cell nadir. Read More

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March 2001
4 Reads

Bcl-2 molecular analysis in paraffin-embedded biopsies from diffuse large B-cell lymphomas.

Medicina (B Aires) 2000 ;60(3):305-10

Departamento de Genética, Academia Nacional de Medicina, Buenos Aires.

Translocation t(14; 18) has been observed in 50-85% of follicular and in 30% of diffuse non-Hodgkin lymphomas. About half of follicle center lymphoma (FCL) undergo histological conversion at relapse to more aggressive diffuse large B-cell lymphoma (DLBCL). This report correlates the molecular bcl-2/IgH rearrangement by PCR and Bcl-2 immunohistochemical (IHC) expression in a series of high grade DLBCLs with and without FCL remnant. Read More

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November 2000
4 Reads

Primary colorectal lymphoma.

Dis Colon Rectum 2000 Sep;43(9):1277-82

Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan.

Purpose: The purpose of this study was to review the clinical presentation and characteristics of primary colorectal lymphoma, analyze the prognostic factors, and assess the results of treatment with adjuvant chemotherapy.

Methods: We identified 37 cases at our institution between 1980 and 1996. They comprised 0. Read More

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September 2000
6 Reads

Primary colonic lymphoma.

J Surg Oncol 2000 Aug;74(4):257-62

Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75235, USA.

Background And Objectives: The colon is a rare location for gastrointestinal non-Hodgkin's lymphoma (NHL). This study was undertaken to identify risk factors, presentation, treatment, and prognosis for primary colonic lymphoma (PCL) through review of a large tertiary care hospital system experience.

Methods: A retrospective review of all patients with colonic malignancy and NHL was performed using pathology and cancer registry databases from January 1989 to December 1998. Read More

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August 2000
6 Reads

CNS involvement in children with newly diagnosed non-Hodgkin's lymphoma.

J Clin Oncol 2000 Aug;18(16):3018-24

Departments of Hematology/Oncology, Radiation Therapy, Pathology and Laboratory Medicine, and Biostatistics, St Jude Children's Research Hospital, and University of Tennessee at Memphis, College of Medicine, Memphis, TN, USA.

Purpose: To determine the frequency of CNS involvement at diagnosis of non-Hodgkin's lymphoma (NHL), to characterize its pattern of presentation, and to determine its prognostic significance.

Patients And Methods: We reviewed the records of 445 children (1975 through 1995) diagnosed with NHL (small noncleaved cell NHL/B-cell acute lymphoblastic leukemia [SNCC NHL/B-ALL], 201 patients; lymphoblastic, 113; large cell, 119; other, 12). Tumor burden was estimated by serum lactate dehydrogenase (LDH) measurement and reclassification of disease stage irrespective of CNS involvement (modified stage). Read More

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http://dx.doi.org/10.1200/JCO.2000.18.16.3018DOI Listing
August 2000
4 Reads

The histologic classification of 602 cases of feline lymphoproliferative disease using the National Cancer Institute working formulation.

J Vet Diagn Invest 2000 Jul;12(4):295-306

College of Veterinary Medicine, University of Illinois, Urbana 61802, USA.

Case information and histologic slides for 688 admissions of feline tissues from 12 veterinary institutions were assembled and reviewed to determine tissues obtained by biopsy or necropsy, age and sex of cat, tumor topography, feline leukemia viral antigen status, histologic frequency of mitoses, diagnosis, presence of necrosis, and presence and degree of sclerosis. Histologic sections were examined to place the lesions in one of the diagnostic categories of the National Cancer Institute working formulation (NCI WF) for lymphomas or lymphoid leukemia. Correlations between the various factors determined were tested using contingency tables and chi-square analysis to provide a statistical comparison between the levels of observations determined by case examination with the numbers expected from chance alone. Read More

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http://dx.doi.org/10.1177/104063870001200401DOI Listing
July 2000
4 Reads

[Burkitt's lymphoma occurring as a primary lymphomatous effusion].

Rinsho Ketsueki 2000 Apr;41(4):329-33

Division of Transfusion Medicine, Yamagata University Hospital.

A 39-year-old man was admitted with massive ascites. Specimens of ascitic fluid contained numerous cells with a FAB-L3 appearance, and small noncleaved cell lymphoma morphology. These cells expressed CD10, CD19, CD20, CD38, CD45, HLA-DR, and IgM antigens, and were positive for IgM and c-myc protein in cytoplasmic immunostaining tests. Read More

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April 2000
3 Reads

Predictive factors for central nervous system involvement in non-Hodgkin's lymphoma: significance of very high serum LDH concentrations.

Leuk Lymphoma 2000 Jul;38(3-4):335-43

Department of Hematology and Chemotherapy, Kanagawa Cancer Center, Yokohama, Japan.

Factors predictive for central nervous system (CNS) involvement at presentation were investigated in 152 patients with non-Hodgkin's lymphoma (NHL) except for lymphoblastic cell lymphoma and small noncleaved cell lymphoma. Twelve patients developed CNS involvement during their disease course. The incidence was 7. Read More

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http://dx.doi.org/10.3109/10428190009087024DOI Listing
July 2000
3 Reads

Outcome of CNS disease at diagnosis in disseminated small noncleaved-cell lymphoma and B-cell leukemia: a Children's Cancer Group study.

J Clin Oncol 2000 May;18(10):2017-25

Memorial Sloan-Kettering Cancer Center and New York University Medical Center, New York, NY, USA.

Purpose: To examine the impact of initial CNS involvement on outcome and patterns of failure in patients with disseminated small noncleaved-cell lymphoma and B-cell leukemia who were treated in four successive Children's Cancer Group trials.

Patients And Methods: Of 462 patients with disseminated disease, 49 (10.6%) had CNS disease at diagnosis (CNS+). Read More

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http://dx.doi.org/10.1200/JCO.2000.18.10.2017DOI Listing
May 2000
8 Reads

[AIDS-related malignant lymphoma].

Authors:
T Nakamura

Nihon Rinsho 2000 Mar;58(3):669-72

Division of Infectious Diseases and Applied Immunology, University of Tokyo.

Patients with HIV-1 infection have high risk for malignant lymphoma(AIDS lymphoma). In Japanese patients, more than 90% of AIDS lymphoma are related to EBV. All 22 cases which we have experienced are non-Hodgkin's lymphoma and their histological classification is either diffuse large or diffuse immunoblastic. Read More

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March 2000
3 Reads

Molecular and virologic characteristics of lymphoid malignancies in children with AIDS.

J Acquir Immune Defic Syndr 2000 Feb;23(2):152-9

Baylor College of Medicine, Texas Children's Cancer Center, Hematology Service, Houston, USA.

Purpose: To characterize AIDS-associated lymphoid malignancies in children.

Patients And Methods: We studied lymphomas and B-cell leukemias from 25 children with AIDS for immunoglobulin heavy chain gene clonality, c-myc oncogene abnormalities, and presence of HIV and Epstein-Barr virus.

Results: Monoclonal immunoglobulin gene rearrangements were identified in 22 of 23 cases tested, the single exception being one of mucosa-associated lymphoid tissue. Read More

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February 2000
2 Reads

Lack of expression of surface immunoglobulin light chains in B-cell non-Hodgkin lymphomas.

Am J Clin Pathol 2000 Mar;113(3):399-405

Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University Medical Center, St Louis, MO 63110, USA.

We describe 10 cases of B-cell non-Hodgkin lymphoma (NHL) that did not express immunoglobulin kappa or lambda light chains by dual-color flow cytometry. Cases were identified from 298 consecutive cases of B-cell NHL and included follicular center cell lymphoma, diffuse large B-cell lymphoma, small noncleaved cell lymphoma, and small lymphocytic lymphoma. One case did not express any immunoglobulin heavy chain (IgH) as well; however, isolated expression of IgG heavy chain was seen in another case. Read More

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http://dx.doi.org/10.1309/28ED-MM0T-DT3B-MT4PDOI Listing
March 2000
4 Reads

The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia.

Blood 2000 Jan;95(2):627-32

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

Chemotaxis in leukocytes is mediated through binding of soluble chemokines to transmembrane G-protein coupled receptors. The chemokine receptor CXCR3 has been previously shown to be widely expressed on activated T cells and to mediate T-cell chemotaxis on binding to various ligands, including Mig, IP-10, and ITAC. By using immunohistochemical and flow cytometric analysis, we report that CXCR3 is also expressed on a subset of peripheral blood B cells and in distinct subtypes of B-cell lymphoma. Read More

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http://www.bloodjournal.org/content/95/2/627.full.pdf
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January 2000
3 Reads

Serum sCD23 level in patients with AIDS-related non-Hodgkin's lymphoma is associated with absence of Epstein-Barr virus in tumor tissue.

Clin Immunol 1999 Dec;93(3):239-44

Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland, USA.

The cytokine soluble CD23 (sCD23) acts as a B cell growth factor and is associated with Epstein-Barr virus (EBV) infection. To elucidate the role sCD23 might play in the pathogenesis of AIDS-related non-Hodgkin's lymphoma (AIDS NHL), 101 AIDS NHL patients from the Multicenter AIDS Cohort Study were studied. Serum sCD23 within 18 months prior to lymphoma diagnosis was measured for all patients and EBV in tumor tissue was ascertained for 49 patients. Read More

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http://dx.doi.org/10.1006/clim.1999.4793DOI Listing
December 1999
4 Reads

Large proportion of Epstein-Barr virus-associated small noncleaved cell lymphomas among children with non-Hodgkin's lymphoma at a single institution in Moscow, Russia.

Am J Clin Oncol 1999 Oct;22(5):523-5

Department of Hematology-Oncology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis 38101, USA.

To evaluate clinical and biologic features of children with non-Hodgkin's lymphoma (NHL) treated in Moscow, Russia, we studied 53 cases treated in the Republican Children's Hospital from 1990 to 1994. Histologic examination disclosed a predominance of the small noncleaved cell subtype (32 cases, 60%); a smaller percentage of the lymphoblastic and large-cell subtypes (14 cases, 26% and 7 cases, 13%, respectively) were identified. The frequencies of primary sites of involvement in descending order included 60% in abdomen, 19% in mediastinum, 15% in head/neck, and 4% in peripheral nodes. Read More

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October 1999
3 Reads

The development of AIDS-associated Burkitt's/small noncleaved cell lymphoma is preceded by elevated serum levels of interleukin 6.

Clin Immunol 1999 Sep;92(3):293-9

Department of Microbiology, Immunology, and Molecular Genetics, UCLA School of Medicine, Los Angeles, California, 90095, USA.

B cell hyperactivation accompanies HIV infection and is believed to contribute to the increased incidence of B cell lymphoma in persons with AIDS. To examine B cell activation which precedes the development of AIDS-associated lymphoma, we measured levels of two B cell stimulatory molecules, soluble CD23 (sCD23) and interleukin 6 (IL6), in the serum of HIV-infected individuals prior to the diagnosis of lymphoma. Serum sCD23 was elevated in those subjects who developed lymphoma, compared to AIDS, HIV+, and HIV- controls (P = 0. Read More

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http://dx.doi.org/10.1006/clim.1999.4760DOI Listing
September 1999
6 Reads

Fine-needle aspiration with flow cytometric immunophenotyping for primary diagnosis of intra-abdominal lymphomas.

Diagn Cytopathol 1999 Aug;21(2):98-104

Division of Cytopathology, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Cytomorphology in conjunction with immunophenotypic characterization is becoming increasingly used for the primary diagnosis of non-Hodgkin's lymphomas (NHL). This combination is especially advantageous for the diagnosis of intra-abdominal and intrathoracic lymphomas, since unlike superficial lesions, open biopsy of deep-seated tissues is more invasive and more costly, and is associated with a higher risk. We report the cytologic and immunophenotypic features of intra-abdominal NHL obtained by fine-needle aspiration (FNA). Read More

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August 1999
3 Reads

Small noncleaved, non-Burkitt's (Burkit-Like) lymphoma: cytogenetics predict outcome and reflect clinical presentation.

J Clin Oncol 1999 May;17(5):1558-67

Division of Medical Oncology, British Columbia Cancer Agency and University of British Columbia, Vancouver, Canada.

Purpose: To correlate cytogenetic abnormalities with clinical presentation and outcome in Burkitt-like, small noncleaved non-Burkitt's lymphoma (SNC-NB).

Patients And Methods: Thirty-nine patients with SNC-NB lymphoma and a clonal karyotype were evaluated between January 1989 and January 1996. All were from British Columbia, Canada, underwent uniform clinical staging, and were treated on investigational protocols by a small group of clinicians. Read More

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http://dx.doi.org/10.1200/JCO.1999.17.5.1558DOI Listing
May 1999
4 Reads

Treatment of localized primary non-Hodgkin's lymphoma of bone in children: a Pediatric Oncology Group study.

J Clin Oncol 1999 Feb;17(2):456-9

Department of Pediatrics, Stanford University School of Medicine, and Lucile Salter Packard Children's Hospital at Stanford, CA 94305-5208, USA.

Purpose: The treatment of primary lymphoma of bone (PLB) in children has traditionally included radiotherapy to the primary site; more recently, it has included systemic chemotherapy. Because of concern about the untoward effects of treatment in a disease that is curable, we attempted to determine whether radiotherapy can be safely excluded from treatment.

Patients And Methods: The results of three consecutive Pediatric Oncology Group (POG) studies were examined to determine the impact on outcome of radiotherapy as adjunctive treatment in children and adolescents receiving chemotherapy for early-stage primary lymphoma of bone. Read More

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http://dx.doi.org/10.1200/JCO.1999.17.2.456DOI Listing
February 1999
2 Reads

[Small noncleaved cell lymphoma, non-Burkitt's type].

Authors:
M Mizuki Y Kanakura

Ryoikibetsu Shokogun Shirizu 1998 (22 Pt 3):265-7

Department of Hematology and Oncology, Osaka University Medical School.

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March 1999
3 Reads

[Small noncleaved cell lymphoma, Burkitt's type].

Authors:
M Mizuki Y Kanakura

Ryoikibetsu Shokogun Shirizu 1998 (22 Pt 3):262-4

Department of Hematology and Oncology, Osaka University Medical School.

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March 1999
3 Reads

Management of high-grade lymphomas.

Authors:
I T Magrath

Oncology (Williston Park) 1998 Oct;12(10 Suppl 8):40-8

Lymphoma Biology Section, National Cancer Institute, Bethesda, Maryland, USA.

High-grade non-Hodgkin's lymphomas generally refer to immunoblastic lymphoma, lymphoblastic lymphoma, and small-noncleaved-cell lymphoma, three histological subtypes that were associated with the worst prognosis at the time of categorization 16 years ago in the Working Formulation for Clinical Usage. Small-noncleaved-cell lymphoma was classified further into Burkitt's lymphoma and non-Burkitt's lymphoma. The treatment of high-grade lymphomas in adults remains somewhat unfavorable today. Read More

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October 1998
6 Reads

Malignant lymphoma in Thailand: changes in the frequency of malignant lymphoma determined from a histopathologic and immunophenotypic analysis of 425 cases at Siriraj Hospital.

Cancer 1998 Sep;83(6):1197-204

Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Analysis of malignant lymphoma in a single institution at different periods of time can determine the changing status of the disease in the region.

Methods: To compare with the large series of 1095 lymphoma cases reported between 1957-1971 at Siriraj Hospital, the largest hospital in Thailand, a similar study was performed through histopathologic evaluation of 425 lymphoma cases diagnosed consecutively at the same institution between August 1993 and October 1995. Phenotypic analysis was performed by paraffin section-immunoperoxidase studies. Read More

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September 1998
6 Reads

Chromosomal abnormalities and molecular genetics of non-Hodgkin's lymphoma.

Authors:
S T Ong M M Le Beau

Semin Oncol 1998 Aug;25(4):447-60

Section of Hematology/Oncology, and the Cancer Research Center, The University of Chicago, IL 60637, USA.

A number of recurring cytogenetic abnormalities have been identified in lymphomas that correlate with clinical, morphologic, and immunophenotypic features. For example, the t(14;18) is observed in a high proportion of follicular small cleaved cell lymphomas, most patients with translocations involving 3q27 have diffuse large cell lymphomas (B cell), and patients with a t(8;14) have either small noncleaved cell or diffuse large cell lymphomas. In contrast, a large proportion of neoplasms of T-cell origin are characterized by rearrangements that involve 14q11, 7q34-35, or 7p15. Read More

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August 1998
4 Reads

The clonal relationship between nodular sclerosis Hodgkin's disease with a clonal Reed-Sternberg cell population and a subsequent B-cell small noncleaved cell lymphoma.

Mod Pathol 1998 May;11(5):485-90

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135, USA.

We evaluated the clonal relationship between a case of nodular sclerosis Hodgkin's disease (NSHD) and a small noncleaved cell (SNC) lymphoma that subsequently developed. Single Hodgkin and Reed-Sternberg (H-RS) cells were isolated from immunostained sections of the NSHD by micromanipulation, and the immunoglobulin heavy chain gene (IgH) complementarity determining region (CDR) III of the cells was amplified by the polymerase chain reaction (PCR). A clonal population of H-RS cells was found in the NSHD tumor. Read More

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May 1998
5 Reads

Immunohistochemical detection of E2F-1 in non-Hodgkin's lymphomas: a survey of 124 cases.

Mod Pathol 1998 May;11(5):457-63

Division of Pathology, City of Hope National Medical Center, Duarte, California, USA.

E2F-1 is a transcription factor that mediates cell cycle progression from the G1 to S phase and is normally regulated by a group of proteins, including cyclin D1. Although deregulation of E2F-1 is implicated in neoplastic transformation, in situ examination of this protein has not been performed to date. Using an immunohistochemical technique applied to routinely fixed, paraffin-embedded tissue sections, we evaluated E2F-1 expression in reactive lymphoid tissues and in 124 cases of non-Hodgkin's lymphoma (NHL) of various types. Read More

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May 1998
4 Reads

Detection of t(8;14)(q24;q32) by polymerase chain reaction for long DNA targets: a report of two patients with B-cell non-Hodgkin's lymphoma.

Int J Hematol 1998 Jan;67(1):75-9

First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.

We developed a novel technique for long-distance polymerase chain reaction (LD-PCR) to detect t(8;14)(q24;q32). LD-PCR can amplify up to 12 kb of DNA encompassing the c-MYC and constant regions of the immunoglobulin heavy chain gene. In this report, we present two patients with B-cell non-Hodgkin's lymphoma. Read More

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January 1998
2 Reads

Systemic small noncleaved cell lymphoma presenting as a posterior choroidal mass.

Am J Ophthalmol 1998 Apr;125(4):560-2

Department of Ophthalmology and Visual Science, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.

Purpose: To describe a patient with intraocular involvement by systemic, small noncleaved cell lymphoma.

Methods: Case report and review of the literature.

Results: A patient presented with a diffusely elevated choroidal mass. Read More

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April 1998
2 Reads

Differential expression of BCL-6, CD138/syndecan-1, and Epstein-Barr virus-encoded latent membrane protein-1 identifies distinct histogenetic subsets of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas.

Blood 1998 Feb;91(3):747-55

Division of Pathology, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.

This study was aimed at defining the histogenesis of the pathologic spectrum of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas (AIDS-NHL), including AIDS-related small noncleaved cell lymphoma (AIDS-SNCCL), AIDS-related large noncleaved cell lymphoma (AIDS-LNCCL), AIDS-related large cell immunoblastic lymphoma plasmacytoid (AIDS-IBLP), and AIDS-related primary effusion lymphoma (AIDS-PEL). Forty-six cases of AIDS-NHL were investigated for the expression pattern of BCL-6, a protein specifically expressed by germinal center (GC) B-cells, and CD138/syndecan-1 (syn-1), a marker of post-GC B-cell differentiation. Expression of BCL-6 and syn-1 segregated two major phenotypic patterns among AIDS-NHL: (1) the BCL-6+/syn-1- pattern associated with AIDS-SNCCL and AIDS-LNCCL; (2) the BCL-6-/syn-1+ pattern associated with AIDS-IBLP and AIDS-PEL. Read More

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February 1998
2 Reads

Clinical quiz. Non-Burkitt, small noncleaved cell-type malignant lymphoma.

J Pediatr Gastroenterol Nutr 1998 Jan;26(1):118, 120

Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana, USA.

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January 1998
2 Reads

Non-African Burkitt lymphoma presenting with oral thrush and an orbital mass in a child.

Am J Ophthalmol 1997 Dec;124(6):859-61

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Purpose: To report an unusual case of orbital involvement with non-African Burkitt lymphoma in a child.

Methods: A 26-month-old boy developed oral thrush and painless right proptosis with eyelid swelling. Magnetic resonance imaging disclosed a diffuse mass involving the inferior, lateral, and superior right orbit and both maxillary sinuses. Read More

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December 1997
2 Reads

Intravascular lymphomatosis presenting as adult respiratory distress syndrome.

Am J Hematol 1997 Nov;56(3):155-60

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

An unusual case of intravascular lymphomatosis caused by small noncleaved, non-Burkitt's lymphoma, which presented with adult respiratory distress syndrome, is described. Extensive invasion of the small- and medium-size blood vessels of the lung, liver, spleen, kidneys, heart, esophagus, stomach, small and large intestines, bladder, and brain-but not the bone marrow or peripheral blood-is documented. The possible mechanism and the unusual features of this case are discussed in comparison with previously reported cases. Read More

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November 1997
3 Reads