290 results match your criteria Lymphoma Malignant Small Noncleaved

Feline Lymphoma and a High Correlation with Feline Leukaemia Virus Infection in Brazil.

J Comp Pathol 2019 Jan 29;166:20-28. Epub 2018 Nov 29.

Laboratory of Animal Pathology, Agroveterinary Sciences Center, Brazil. Electronic address:

Lymphoma is the most important haemopoietic tumour in cats and has been associated with feline leukaemia virus (FeLV) infection. In Brazil, no studies have established a correlation between FeLV infection and lymphoma. The aim of this study was to characterize lymphomas arising in cats in Brazil anatomically and microscopically, and to correlate these data with FeLV infection as determined by immunohistochemistry for the FeLV gp70 antigen. Read More

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January 2019

Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature.

Radiat Oncol 2013 Jun 20;8:147. Epub 2013 Jun 20.

Primary cutaneous follicle center lymphoma is an indolent primary cutaneous B-cell lymphoma originating from the follicle center cells, composed of a combination of centrocytes (small and large cleaved cells) and centroblasts (large noncleaved cells) with a follicular, follicular/diffuse, or diffuse growth pattern. Lesions are mostly located on the head, neck and trunk. A case is presented of a 56-year-old male patient with primary cutaneous follicle center lymphoma, with lesions involving the skin of the back, shoulders, presternal area and right forearm. Read More

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Post-transplant Burkitt lymphoma is a more aggressive and distinct form of post-transplant lymphoproliferative disorder.

Cancer 2011 Oct 28;117(19):4540-50. Epub 2011 Mar 28.

Department of Pediatric Pathology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background: Although the literature reports a low incidence of Burkitt lymphoma (BL) as a post-transplant lymphoproliferative disorder (PTLD), this entity appears to be different from other monomorphic PTLDs (M-PTLDs), both in its aggressive clinical presentation and its distinct pathologic profile.

Methods: Patients with BL, diagnosed in the post-transplant setting, (patients aged ≤ 18 years) were retrieved from the pathology archives at Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center from 1982 to 2010. Clinical outcomes were obtained along with pathologic review. Read More

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October 2011

Retrospective study of 82 cases of canine lymphoma in Austria based on the Working Formulation and immunophenotyping.

J Comp Pathol 2007 Feb-Apr;136(2-3):186-92

Central Laboratory, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria.

In human beings the prevalence of different non-Hodgkin's lymphoma (NHL) subtypes varies according to geographical region. The aim of this study was to classify canine lymphomas in Austria and to compare the results with those of similar studies in other countries. Eighty-two NHLs were classified according to their morphology (based on the Working Formulation) and their immunophenotype (determined with anti-T-cell and anti-B-cell antibodies). Read More

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The feasibility of gene expression profiling generated in fine-needle aspiration specimens from patients with follicular lymphoma and diffuse large B-cell lymphoma.

Cancer 2006 Feb;108(1):10-20

Department of Lymphoma and Myeloma, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

Lymphoma of germinal center cell (GC) origin generally is an indolent malignancy that transforms progressively into a more aggressive disease. According to the World Health Organization classification, lymphomas of follicular center cell origin are classified as either large B-cell lymphoma (LBCL) or follicular lymphoma (FL). The authors tested the feasibility of performing gene expression profiling using amplified RNA from fine-needle aspirates (FNA) obtained from lymph nodes. Read More

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February 2006

Human immunodeficiency virus-associated lymphoma.

Clin Adv Hematol Oncol 2003 May;1(5):295-301

Albert Einstein College of Medicine, USA.

Infection with the human immunodeficiency virus (HIV) is associated with an increased risk of systemic non-Hodgkin's lymphoma, Hodgkin's disease, and primary central nervous system lymphoma (PCNSL). Systemic lymphoma usually involves extranodal sites (80%-90%) and is usually of intermediate-grade (diffuse large-cell or immunoblastic( or high-grade (diffuse small noncleaved) histology. Approximately one third to one half of patients are cured with the cytotoxic treatment regimens that are used in immunocompetent patients with lymphoma. Read More

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Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas of children and adolescents: a report from Children's Cancer Group Study CCG-E08.

J Pediatr Hematol Oncol 2004 Mar;26(3):169-78

Pathology Department, Children's Hospital of Orange County/St. Joseph Hospital, Orange, California, USA.

Among pediatric non-Hodgkin lymphomas, the most frequent type is small noncleaved-cell lymphoma (including Burkitt and Burkitt-like). Specific chromosome abnormalities are associated with prognosis in childhood acute lymphoblastic leukemia (ALL); however, chromosome abnormalities have not been evaluated for prognostic value in pediatric Burkitt and Burkitt-like lymphomas. For Children's Cancer Group protocol CCG-E-08 Etiologic Study of Non-Hodgkin Lymphoma in Childhood, 19 patients were enrolled with cytogenetic analysis of Burkitt or Burkitt-like lymphoma and simultaneously enrolled on treatment protocols CCG-503 or CCG-552. Read More

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The adequacy of gross pathological examination of routine tonsils and adenoids in patients 21 years old and younger.

Hum Pathol 2003 Oct;34(10):1053-7

Department of Patholgoy, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610, USA.

Most hospitals microscopically examine all routine tonsil and adenoid specimens from healthy pediatric patients with recurrent infections or obstructive sleep apnea. Concern over missing the rare unsuspected, significant diagnosis propagates this practice. Careful gross examination for asymmetry and clinical findings should obviate the need for routine microscopic examination of tonsil and adenoid specimens in patients age 21 years and younger. Read More

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October 2003

Clinical perspectives of primary cardiac lymphoma.

Angiology 2003 Sep-Oct;54(5):599-604

Division of Cardiology, Long Island College Hospital, Brooklyn, NY, USA.

Primary cardiac lymphoma is a very rare malignancy, which is typically of a non-Hodgkin type, and involves only the heart and pericardium with no or minimal evidence of extracardiac involvement. Primary cardiac lymphoma account for about 1% of the primary cardiac tumors and 0.5% of the extranodal lymphomas. Read More

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November 2003

Burkitt's lymphoma in the base of the tongue: differential diagnosis and management.

ORL J Otorhinolaryngol Relat Spec 2003 Jul-Aug;65(4):226-9

Otorhinolaryngology Department, Ippokration Hospital, Athens University, Athens, Greece.

Burkitt's lymphoma is the most common malignancy in African children but can occur sporadically in every country. It is one of the most aggressive malignancies in the human body, and in the past the prognosis was very poor. However, complex chemotherapy regimens can now cure approximately 50-80% of adult patients with Burkitt's lymphoma or small noncleaved lymphoma, and in pediatric populations the cure rate is even higher. Read More

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Challenges in the management of Burkitt's lymphoma.

Clin Lymphoma 2002 Dec;3 Suppl 1:S19-25

Norris Cancer Hospital, University of Southern California, Los Angeles 90033-1048, USA.

Burkitt's lymphoma and small noncleaved Burkitt's-like lymphoma are rare and are highly aggressive forms of non-Hodgkin's lymphoma that are characterized by dysregulation of the c-myc oncogene. Patients with human immunodeficiency virus (HIV) also appear to be at risk for developing Burkitt's lymphomas. Treatment options for Burkitt's lymphoma involve complex chemotherapy regimens that contain as many as 10 cytotoxic agents. Read More

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December 2002

B-cell activation and lymphoma in patients with HIV.

Curr Opin Oncol 2002 Sep;14(5):528-32

Department of Microbiology, David Geffen School of Medicine, University of California-Los Angeles, 90095, USA.

The risk of developing non-Hodgkin lymphoma (AIDS lymphoma) is greatly increased in HIV infection. Disruption of immune function by HIV infection may contribute to lymphomagenesis by inducing (1) loss of immunoregulation of Epstein-Barr virus-infected B cells [immunoblastic and central nervous system (CNS) lymphoma] caused by loss of T-cell function, and (2) chronic B-cell hyperactivation enhancing the generation of genetic lesions (c- :immunoglobulin gene translocation, -6 overexpression) associated with some forms of AIDS lymphoma (Burkitt lymphoma-like small noncleaved cell lymphoma and large noncleaved cell lymphoma). Also, the overproduction of B-cell-stimulatory cytokines (interleukin 10 and 6) has the potential to contribute to tumor development by supporting the growth and viability of nascent lymphoma cell clones. Read More

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September 2002

Non-Hodgkin's lymphoma arising in bone in children and adolescents is associated with an excellent outcome: a Children's Cancer Group report.

J Clin Oncol 2002 May;20(9):2293-301

Pathology Department, Children's Hospital of Orange County/St Joseph Hospital, Orange, CA, USA.

Purpose: Non-Hodgkin's lymphoma (NHL) arising in bone is a heterogeneous histologic type of NHL that includes large-cell lymphoma, lymphoblastic lymphoma, and small noncleaved-cell lymphoma. NHL arising in bone is well recognized in adults but is less well characterized and infrequent in children and adolescents.

Patients And Methods: We performed a retrospective review of Children's Cancer Group (CCG) studies treating children and adolescents with NHL over a 20-year period (CCG-551, CCG-501, CCG-502, CCG-503, CCG-552, CCG-5911, and CCG-5941) and determined the response and event-free survival (EFS) rates in 31 patients with NHL arising in bone. Read More

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Second malignancy after treatment of childhood non-Hodgkin lymphoma.

Cancer 2001 Oct;92(7):1959-66

St. Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105-2794, USA.

Background: The objective of this report was to determine the cumulative incidence of and risk factors for second malignancy and the competing risk of death due to any other cause among patients who were treated for childhood non-Hodgkin lymphoma (NHL).

Methods: The authors retrospectively reviewed a cohort of 497 patients with NHL who were treated at St. Jude Children's Research Hospital between 1970 and 1997. Read More

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October 2001

Treatment of high-grade lymphoid malignancies in adults.

C A Schiffer

Semin Hematol 2001 Oct;38(4 Suppl 10):22-6

Division of Hematology/Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.

High-grade, B-lineage lymphoproliferative disorders can have a leukemic (acute lymphocytic leukemia [ALL] French-American-British [FAB] stage L-3), a lymphomatous (Burkitt's or small noncleaved [SNC]), or often a mixed clinical presentation in adults. Manifestations of these diseases in both adults and children include a propensity for abdominal and CNS involvement and a high incidence of metabolic abnormalities due to rapid cell growth and turnover, which are acutely exacerbated by treatment. Numerous studies show that FAB L-3, Burkitt's lymphoma (BL), and SNC are among the most curable of the multiple leukemia/lymphoma subtypes if treated appropriately. Read More

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October 2001

Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251.

J Clin Oncol 2001 Oct;19(20):4014-22

Department of Medicine, the Alvin and Lois Lapidus Cancer Institute, Sinai Hospital, Baltimore, MD, USA.

Purpose: To define the activity and feasibility of brief-duration high-intensity chemotherapy for adults with small noncleaved, non-Hodgkin's lymphoma (SNC) and the L3 variant of acute lymphocytic leukemia (L3 ALL).

Patients And Methods: Seventy-five adults with either SNC or L3 ALL (median age, 44 years) were treated with an aggressive regimen that consisted of one cycle of cyclophosphamide and prednisone followed by cycles containing either ifosfamide or cyclophosphamide; high-dose methotrexate, vincristine, dexamethasone, and either doxorubicin or etoposide/cytarabine; or intrathecal triple therapy with prophylactic CNS irradiation.

Results: All 24 patients with L3 ALL and the 30 of 51 patients with SNC confirmed by central histologic review were included in this analysis. Read More

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October 2001

Clinical, immunologic, and pathologic correlates of bone marrow involvement in 291 patients with acquired immunodeficiency syndrome-related lymphoma.

Blood 2001 Oct;98(8):2358-63

Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA.

Bone marrow involvement is reported in approximately 25% of patients with newly diagnosed acquired immunodeficiency syndrome-related lymphoma (ARL). Studied were 291 patients with ARL, diagnosed and treated at one medical center between 1984 and 1998. Clinical, immunologic, and pathologic characteristics of patients with bone marrow involvement were compared with those of patients without marrow involvement. Read More

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October 2001

Evolving characteristics of AIDS-related lymphoma.

Blood 2000 Dec;96(13):4084-90

Division of Hematology, Department of Medicine, and Division of Hematopathology, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Over time, the epidemiologic and demographic characteristics of AIDS have changed in the United States, while the use of highly active antiretroviral therapy has changed the natural history of the disease. The goal of the study was to ascertain any changes in the epidemiologic, immunologic, pathologic, or clinical characteristics of AIDS-related lymphoma (ARL) over the course of the AIDS epidemic. Records of 369 patients with ARL diagnosed or treated at a single institution from 1982 through 1998 were reviewed. Read More

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December 2000

Toxicity of high-dose sequential chemotherapy and purged autologous hematopoietic cell transplantation precludes its use in refractory/recurrent non-Hodgkin's lymphoma.

Biol Blood Marrow Transplant 2000 ;6(5A):555-62

Division of Bone Marrow Transplantation, Stanford University, California 94305, USA.

We conducted a pilot study in 20 patients with high-risk or recurrent/refractory non-Hodgkin's lymphoma (NHL) using high-dose sequential chemotherapy (HDSC) and autologous hematopoietic cell transplantation (AHCT). After cytoreduction with standard salvage therapy, HDSC/AHCT was administered in 4 phases at 2- to 4-week intervals. Phase 1 consisted of cyclophosphamide 7 g/m2 followed by granulocyte colony-stimulating factor (G-CSF) at 10 microg/kg per day and leukapheresis upon recovery from white blood cell nadir. Read More

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Bcl-2 molecular analysis in paraffin-embedded biopsies from diffuse large B-cell lymphomas.

Medicina (B Aires) 2000 ;60(3):305-10

Departamento de Genética, Academia Nacional de Medicina, Buenos Aires.

Translocation t(14; 18) has been observed in 50-85% of follicular and in 30% of diffuse non-Hodgkin lymphomas. About half of follicle center lymphoma (FCL) undergo histological conversion at relapse to more aggressive diffuse large B-cell lymphoma (DLBCL). This report correlates the molecular bcl-2/IgH rearrangement by PCR and Bcl-2 immunohistochemical (IHC) expression in a series of high grade DLBCLs with and without FCL remnant. Read More

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November 2000

Primary colorectal lymphoma.

Dis Colon Rectum 2000 Sep;43(9):1277-82

Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan.

Purpose: The purpose of this study was to review the clinical presentation and characteristics of primary colorectal lymphoma, analyze the prognostic factors, and assess the results of treatment with adjuvant chemotherapy.

Methods: We identified 37 cases at our institution between 1980 and 1996. They comprised 0. Read More

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September 2000

Primary colonic lymphoma.

J Surg Oncol 2000 Aug;74(4):257-62

Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75235, USA.

Background And Objectives: The colon is a rare location for gastrointestinal non-Hodgkin's lymphoma (NHL). This study was undertaken to identify risk factors, presentation, treatment, and prognosis for primary colonic lymphoma (PCL) through review of a large tertiary care hospital system experience.

Methods: A retrospective review of all patients with colonic malignancy and NHL was performed using pathology and cancer registry databases from January 1989 to December 1998. Read More

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CNS involvement in children with newly diagnosed non-Hodgkin's lymphoma.

J Clin Oncol 2000 Aug;18(16):3018-24

Departments of Hematology/Oncology, Radiation Therapy, Pathology and Laboratory Medicine, and Biostatistics, St Jude Children's Research Hospital, and University of Tennessee at Memphis, College of Medicine, Memphis, TN, USA.

Purpose: To determine the frequency of CNS involvement at diagnosis of non-Hodgkin's lymphoma (NHL), to characterize its pattern of presentation, and to determine its prognostic significance.

Patients And Methods: We reviewed the records of 445 children (1975 through 1995) diagnosed with NHL (small noncleaved cell NHL/B-cell acute lymphoblastic leukemia [SNCC NHL/B-ALL], 201 patients; lymphoblastic, 113; large cell, 119; other, 12). Tumor burden was estimated by serum lactate dehydrogenase (LDH) measurement and reclassification of disease stage irrespective of CNS involvement (modified stage). Read More

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The histologic classification of 602 cases of feline lymphoproliferative disease using the National Cancer Institute working formulation.

J Vet Diagn Invest 2000 Jul;12(4):295-306

College of Veterinary Medicine, University of Illinois, Urbana 61802, USA.

Case information and histologic slides for 688 admissions of feline tissues from 12 veterinary institutions were assembled and reviewed to determine tissues obtained by biopsy or necropsy, age and sex of cat, tumor topography, feline leukemia viral antigen status, histologic frequency of mitoses, diagnosis, presence of necrosis, and presence and degree of sclerosis. Histologic sections were examined to place the lesions in one of the diagnostic categories of the National Cancer Institute working formulation (NCI WF) for lymphomas or lymphoid leukemia. Correlations between the various factors determined were tested using contingency tables and chi-square analysis to provide a statistical comparison between the levels of observations determined by case examination with the numbers expected from chance alone. Read More

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[Burkitt's lymphoma occurring as a primary lymphomatous effusion].

Rinsho Ketsueki 2000 Apr;41(4):329-33

Division of Transfusion Medicine, Yamagata University Hospital.

A 39-year-old man was admitted with massive ascites. Specimens of ascitic fluid contained numerous cells with a FAB-L3 appearance, and small noncleaved cell lymphoma morphology. These cells expressed CD10, CD19, CD20, CD38, CD45, HLA-DR, and IgM antigens, and were positive for IgM and c-myc protein in cytoplasmic immunostaining tests. Read More

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Predictive factors for central nervous system involvement in non-Hodgkin's lymphoma: significance of very high serum LDH concentrations.

Leuk Lymphoma 2000 Jul;38(3-4):335-43

Department of Hematology and Chemotherapy, Kanagawa Cancer Center, Yokohama, Japan.

Factors predictive for central nervous system (CNS) involvement at presentation were investigated in 152 patients with non-Hodgkin's lymphoma (NHL) except for lymphoblastic cell lymphoma and small noncleaved cell lymphoma. Twelve patients developed CNS involvement during their disease course. The incidence was 7. Read More

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Outcome of CNS disease at diagnosis in disseminated small noncleaved-cell lymphoma and B-cell leukemia: a Children's Cancer Group study.

J Clin Oncol 2000 May;18(10):2017-25

Memorial Sloan-Kettering Cancer Center and New York University Medical Center, New York, NY, USA.

Purpose: To examine the impact of initial CNS involvement on outcome and patterns of failure in patients with disseminated small noncleaved-cell lymphoma and B-cell leukemia who were treated in four successive Children's Cancer Group trials.

Patients And Methods: Of 462 patients with disseminated disease, 49 (10.6%) had CNS disease at diagnosis (CNS+). Read More

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[AIDS-related malignant lymphoma].

T Nakamura

Nihon Rinsho 2000 Mar;58(3):669-72

Division of Infectious Diseases and Applied Immunology, University of Tokyo.

Patients with HIV-1 infection have high risk for malignant lymphoma(AIDS lymphoma). In Japanese patients, more than 90% of AIDS lymphoma are related to EBV. All 22 cases which we have experienced are non-Hodgkin's lymphoma and their histological classification is either diffuse large or diffuse immunoblastic. Read More

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Molecular and virologic characteristics of lymphoid malignancies in children with AIDS.

J Acquir Immune Defic Syndr 2000 Feb;23(2):152-9

Baylor College of Medicine, Texas Children's Cancer Center, Hematology Service, Houston, USA.

Purpose: To characterize AIDS-associated lymphoid malignancies in children.

Patients And Methods: We studied lymphomas and B-cell leukemias from 25 children with AIDS for immunoglobulin heavy chain gene clonality, c-myc oncogene abnormalities, and presence of HIV and Epstein-Barr virus.

Results: Monoclonal immunoglobulin gene rearrangements were identified in 22 of 23 cases tested, the single exception being one of mucosa-associated lymphoid tissue. Read More

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February 2000

Lack of expression of surface immunoglobulin light chains in B-cell non-Hodgkin lymphomas.

Am J Clin Pathol 2000 Mar;113(3):399-405

Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University Medical Center, St Louis, MO 63110, USA.

We describe 10 cases of B-cell non-Hodgkin lymphoma (NHL) that did not express immunoglobulin kappa or lambda light chains by dual-color flow cytometry. Cases were identified from 298 consecutive cases of B-cell NHL and included follicular center cell lymphoma, diffuse large B-cell lymphoma, small noncleaved cell lymphoma, and small lymphocytic lymphoma. One case did not express any immunoglobulin heavy chain (IgH) as well; however, isolated expression of IgG heavy chain was seen in another case. Read More

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