1,032 results match your criteria Lymphoma Malignant Anaplastic Ki 1+


Colonic CD30 positive plasmablastic plasmacytoma masquerading as anaplastic large cell lymphoma.

Pathology 2018 10 8;50(6):668-670. Epub 2018 Aug 8.

Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan; Department of Pathology, School of Medicine, Taipei Medical University and National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.pathol.2018.03.011DOI Listing
October 2018
3 Reads

CD30, CD15, CD50, and PAX5 Expressions as Diagnostic Markers for Hodgkin Lymphoma (HL) and Systemic Anaplastic Large Cell Lymphoma (sALCL).

Acta Med Indones 2018 Apr;50(2):104-109

Division of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia.

Background: the expression of CD30, CD15, CD50, and PAX5 are used to help in confirming diagnosis of HL and sALCL; however data on the proportion of these markers have not been available. The study was aimed to identify the proportion of CD30, CD15, CD50 and PAX5 expressions and characteristics of patients with HL and sALCL at Dharmais National Cancer Center Hospital between 2005 and 2015.

Methods: a retrospective observational study was conducted using data from medical records and histopathological results of HL and sALCL adult patients who sought treatment at the hospital between 2005 and 2015. Read More

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April 2018
3 Reads

The Role of Reed-Sternberg CD30 Receptor and Lymphocytes in Pathogenesis of Disease and Its Implication for Treatment.

Authors:
Ikhwan Rinaldi

Acta Med Indones 2018 Apr;50(2):93-95

Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Hodgkin lymphoma is a cancer that can be cured using standard chemotherapy with or without radiation. Although it accounts for only 0.6% of all malignancy worldwide, but it usually affects young adults with median age of 38 years. Read More

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April 2018
2 Reads

[Primary cutaneous CD30+ T-cell lymphoproliferation during treatment with fingolimod: Case report and literature review].

Ann Dermatol Venereol 2018 Jun - Jul;145(6-7):433-438. Epub 2018 Apr 17.

Service de dermatologie et d'allergologie, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France; Faculté de médecine, Sorbonne université, 75013 Paris, France. Electronic address:

Background: Fingolimod is an oral immunomodulator approved for relapsing-remitting multiple sclerosis. We report a case of a primary cutaneous CD30+ T-cell lymphoproliferation occurring 6 months after initiation of fingolimod. Based on a systematic literature review, the characteristics of these fingolimod-induced lymphoproliferative disorders are described. Read More

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http://dx.doi.org/10.1016/j.annder.2018.02.010DOI Listing
January 2019
7 Reads

CD30 expression and its correlation with MYC and BCL2 in de novo diffuse large B-cell lymphoma.

J Clin Pathol 2018 Sep 17;71(9):795-801. Epub 2018 Apr 17.

Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Aim: CD30+ diffuse large B-cell lymphoma (DLBCL) has emerged as a new immunophenotypic variant of DLBCLs. However, the prevalence of CD30 positivity is variable according to different studies, and the prognostic significance of CD30 is also controversial. This study aimed to investigate the positive expression rate and prognostic impact of CD30 in DLBCLs and try to find the correlated influences. Read More

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http://dx.doi.org/10.1136/jclinpath-2018-205039DOI Listing
September 2018
5 Reads
2.920 Impact Factor

CD30-positive primary cutaneous anaplastic large cell lymphoma with coexistent pseudocarcinomatous hyperplasia.

Clin Exp Dermatol 2018 Jul 23;43(5):585-588. Epub 2018 Feb 23.

Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Oberhausen, Germany.

CD30-positive primary cutaneous anaplastic large cell lymphoma (C-ALCL) is an indolent type of cutaneous lymphoma with favourable clinical prognosis. Pseudocarcinomatous hyperplasia (PCH) is a rare benign epithelial condition that can resemble invasive squamous cell carcinoma both clinically and histopathologically. PCH predominantly occurs in CD30-positive lymphoproliferative disorders. Read More

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http://doi.wiley.com/10.1111/ced.13416
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http://dx.doi.org/10.1111/ced.13416DOI Listing
July 2018
6 Reads

Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry.

J Vet Diagn Invest 2018 May 19;30(3):455-458. Epub 2018 Feb 19.

Departments of Pathobiology and Population Sciences (Pittaway, Szladovits, Suárez-Bonnet, Priestnall), The Royal Veterinary College, University of London, North Mymms, United Kingdom.

Anaplastic large-cell lymphoma or null-cell lymphoma is a clinical entity reported in people, classified according to the unique appearance of large pleomorphic cells that express CD30. Null-cell lymphoma has also been described in dogs when neither CD3 nor CD79α is expressed by the tumor. We describe a case of lymphoma in the dog in which neoplastic cells did not express routine B- or T-lymphocyte markers on flow cytometry or immunohistochemistry; however, cells immunohistochemically labeled for CD30. Read More

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http://dx.doi.org/10.1177/1040638718760965DOI Listing
May 2018
10 Reads

Phase I clinical study of brentuximab vedotin (SGN-35) involving children with recurrent or refractory CD30-positive Hodgkin's lymphoma or systemic anaplastic large cell lymphoma: rationale, design and methods of BV-HLALCL study: study protocol.

BMC Cancer 2018 02 1;18(1):122. Epub 2018 Feb 1.

Department of Pediatrics, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.

Background: Hodgkin's lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) are the two most common tumors expressing CD30. Internationally, a clinical study that is being conducted involving adults with recurrent or refractory HL or ALCL suggests efficacy of brentuximab vedotin (SGN-35). Pediatric patients should be given medicines that have been appropriately evaluated for their use. Read More

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http://dx.doi.org/10.1186/s12885-018-4042-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796474PMC
February 2018
8 Reads

A novel enediyne-integrated antibody-drug conjugate shows promising antitumor efficacy against CD30 lymphomas.

Mol Oncol 2018 03 26;12(3):339-355. Epub 2018 Jan 26.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

CD30 is a 120-kDa type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily. Overexpression of CD30 has been reported in Hodgkin's lymphoma (HL) and anaplastic large-cell lymphoma (ALCL). CD30-targeted treatment with antibody-drug conjugates (ADCs) can lead to promising clinical benefit. Read More

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http://doi.wiley.com/10.1002/1878-0261.12166
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http://dx.doi.org/10.1002/1878-0261.12166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830626PMC
March 2018
7 Reads

Anaplastic large cell lymphoma: pathology, genetics, and clinical aspects.

J Clin Exp Hematop 2017 ;57(3):120-142

Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research.

Anaplastic large cell lymphoma (ALCL) was first described in 1985 as a large-cell neoplasm with anaplastic morphology immunostained by the Ki-1 antibody, which recognizes CD30. In 1994, the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion receptor tyrosine kinase was identified in a subset of patients, leading to subdivision of this disease into ALK-positive and -negative ALCL in the present World Health Organization classification. Due to variations in morphology and immunophenotype, which may sometimes be atypical for lymphoma, many differential diagnoses should be considered, including solid cancers, lymphomas, and reactive processes. Read More

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http://dx.doi.org/10.3960/jslrt.17023DOI Listing
July 2018
6 Reads

[Clinicopathologic characteristics and prognosis of neoplastic cell-rich mixed cellularity classic Hodgkin lymphoma].

Zhonghua Bing Li Xue Za Zhi 2017 Oct;46(10):708-713

Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

To investigate the clinicopathologic characteristics of neoplastic cell-rich mixed cellularity classical Hodgkin lymphoma(MCCHL-R) and to compare the prognosis with typical mixed cellularity classic Hodgkin lymphoma(MCCHL). Fifty-four patients with MCCHL-R(the tumor cells >10%) and 65 patients with typical MCCHL identified from 1 721 Hodgkin lymphomas were reviewed to compare the clinicopathological characteristics including morphologic and immunophenotypic features, EBV infection status, clinical therapy and overall survival. The median age of the patients of MCCHL-R was 28. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2017.10.010DOI Listing
October 2017
2 Reads

Breast Implant-Associated Anaplastic Large-Cell Lymphoma in a Transgender Woman.

Aesthet Surg J 2017 Sep;37(8):NP83-NP87

Department of Plastic, Reconstructive, and Hand Surgery, Maastricht University Medical Center, Maastricht, the Netherlands. Department of Plastic, Reconstructive, and Hand Surgery, VU University Medical Center, Amsterdam, the Netherlands. Department of Oncology, Netherlands Cancer Institute, Amsterdam. Dutch Nationwide Network and Registry of Histo- and Cytopathology, Houten, the Netherlands. Division of Epidemiology, Netherlands Cancer Institute, Amsterdam. Department of Plastic, Reconstructive, and Hand Surgery, MST, Enschede, the Netherlands, Dutch Society of Plastic Surgery. Division of Plastic, Reconstructive, and Hand Surgery, Maastricht University Medical Center. Department of Pathology, VU University Medical Center. Department of Plastic, Reconstructive, and Hand Surgery, VU University Medical Center. Center of Expertise on Gender Dysphoria at the VU University Medical Center. Division of Pathology, VU University Medical Center. Dutch BIA-ALCL Consortium.

Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare but serious complication in patients with breast implants, Patients are at risk of BIA-ALCL whether they receive breast implants for cosmetic reasons or for reconstructive purposes after surgery for breast cancer or prophylactic mastectomy. During the past decade, an increased number of reports have addressed BIA-ALCL. Herein, we describe BIA-ALCL in a transgender woman. Read More

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http://dx.doi.org/10.1093/asj/sjx098DOI Listing
September 2017
23 Reads

Understanding CD30 biology and therapeutic targeting: a historical perspective providing insight into future directions.

Blood Cancer J 2017 09 8;7(9):e603. Epub 2017 Sep 8.

Department of Haematology, Peter McCallum Cancer Centre, Melbourne, Victoria, Australia.

CD30 is a member of the tumor necrosis factor receptor superfamily. It is characteristically expressed in certain hematopoietic malignancies, including anaplastic large cell lymphoma and Hodgkin lymphoma, among others. The variable expression of CD30 on both normal and malignant lymphoid cells has focused research efforts on understanding the pathogenesis of CD30 upregulation, its contribution to lymphomagenesis through anti-apoptotic mechanisms, and its effect on cell survival. Read More

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http://www.nature.com/doifinder/10.1038/bcj.2017.85
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http://dx.doi.org/10.1038/bcj.2017.85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709754PMC
September 2017
23 Reads

Monoclonal antibodies against cutaneous T-cell lymphomas.

Authors:
Mauro Alaibac

Expert Opin Biol Ther 2017 12 28;17(12):1503-1510. Epub 2017 Aug 28.

a Unit of Dermatology, Department of Medicine , University of Padua , Padua , Italy.

Introduction: Cutaneous T-cell lymphomas (CTCLs) comprise of a group of rare and heterogeneous skin lymphoproliferative disorders derived from skin resident T cells. Treatment of CTCLs is based on skin-directed approaches and/or systemic therapies. Advanced CTCLs are difficult to treat with the currently available treatments as they generally fail to obtain prolonged clinical remission. Read More

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http://dx.doi.org/10.1080/14712598.2017.1369951DOI Listing
December 2017
4 Reads

Clinical and immunological responses after CD30-specific chimeric antigen receptor-redirected lymphocytes.

J Clin Invest 2017 Sep 14;127(9):3462-3471. Epub 2017 Aug 14.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, Texas, USA.

Background: Targeting CD30 with monoclonal antibodies in Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) has had profound clinical success. However, adverse events, mainly mediated by the toxin component of the conjugated antibodies, cause treatment discontinuation in many patients. Targeting CD30 with T cells expressing a CD30-specific chimeric antigen receptor (CAR) may reduce the side effects and augment antitumor activity. Read More

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http://dx.doi.org/10.1172/JCI94306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669573PMC
September 2017
22 Reads

Brentuximab vedotin therapy for CD30-positive cutaneous T-cell lymphoma: a targeted approach to management.

Future Oncol 2017 Nov 14;13(27):2405-2411. Epub 2017 Aug 14.

Dermatology - University Hospitals Birmingham NHS Foundation Trust, University Hospital Birmingham, Birmingham, B15 2TH, UK.

CD30-positive primary cutaneous T-cell lymphoma (CTCL) includes mycosis fungoides, anaplastic large-cell lymphoma and lymphomatoid papulosis type A. Brentuximab vedotin (BV) consists of an antibody targeting CD30 with a protease-cleavable linker to vedotin. CD30 binding allows internalization of BV inducing cell-cycle arrest and apoptosis. Read More

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http://dx.doi.org/10.2217/fon-2017-0263DOI Listing
November 2017
8 Reads

Brentuximab vedotin in CD30 primary cutaneous T-cell lymphomas: a review and analysis of existing data.

Int J Dermatol 2017 Dec 1;56(12):1400-1405. Epub 2017 Aug 1.

Department of Dermatology, University of Texas Southwestern, Dallas, TX, USA.

Background: The utility of brentuximab vedotin (BV) in CD30 systemic lymphomas is established, however evidence for treating primary cutaneous lymphoma remains limited. This study aimed to evaluate BV in treating CD30 transformed mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma (PC-ALCL).

Methods: A literature review was conducted, and we analyzed data from published trials and case reports obtained via search of Ovid-MEDLINE and PubMed databases. Read More

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http://dx.doi.org/10.1111/ijd.13696DOI Listing
December 2017
5 Reads

Cytological diagnostic features of late breast implant seromas: From reactive to anaplastic large cell lymphoma.

PLoS One 2017 17;12(7):e0181097. Epub 2017 Jul 17.

Department of Clinical and Molecular Medicine, Sapienza University, Cytology Unit, Sant'Andrea Hospital, Roma, Italy.

Late breast implant seroma may be the presentation of a breast implant-associated anaplastic large cell lymphoma (BI-ALCL), which claims for a prompt recognition. However, BI-ALCL diagnosis on fine-needle aspiration (FNA) might be challenging for pathologists lacking experience with peri-implant breast effusions. Sixty-seven late breast implant seromas collected by FNA from 50 patients were evaluated by Papanicolaou smear stain and immunocytochemistry on cell blocks. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181097PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513491PMC
September 2017
73 Reads

Upregulation of inhibitory signaling receptor programmed death marker-1 (PD-1) in disease evolution from cutaneous lymphoid dyscrasias to mycosis fungoides and Sezary's syndrome.

Ann Diagn Pathol 2017 Jun 10;28:54-59. Epub 2017 Feb 10.

Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY 10065, USA. Electronic address:

Background: Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but the expression profile of PD-1 and mycosis fungoides (MF) remains largely to be characterized. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2017.02.003DOI Listing
June 2017
13 Reads

Disseminated CD8-positive, CD30-positive cutaneous lymphoproliferative eruption with overlapping features of mycosis fungoides and primary cutaneous anaplastic large cell lymphoma following remote solitary lesional presentation.

J Cutan Pathol 2017 Aug 13;44(8):703-712. Epub 2017 Jun 13.

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

CD8-positive, CD30-positive cutaneous lymphoproliferative disorders constitute a rare subset of T-cell lymphoproliferative conditions, including variants of primary cutaneous anaplastic large cell lymphoma (ALCL), mycosis fungoides, lymphomatoid papulosis type D, cutaneous gamma-delta T-cell lymphoma and cutaneous peripheral T-cell lymphoma. These entities share overlapping clinical, histopathologic and immunophenotypic features, presenting both a clinical and pathological diagnostic challenge. Presented here is a 73-year-old man with a disseminated, indolent CD30+, CD8+ cutaneous lymphoproliferative disorder with overlapping clinical and histopathological features of both mycosis fungoides and primary cutaneous ALCL, as well as features of lymphomatoid papulosis. Read More

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http://dx.doi.org/10.1111/cup.12961DOI Listing
August 2017
23 Reads

A case of CD30+ ALK1- anaplastic large cell lymphoma resembling acute disseminated encephalomyelitis.

Mult Scler Relat Disord 2017 Apr 6;13:119-121. Epub 2017 Mar 6.

B' Department of Neurology, AHEPA University Hospital, Kyriakidi Str., 54636 Thessaloniki, Greece.

Central nervous system involvement is an uncommon complication of systemic non-Hodgkin lymphomas. The majority of these cases concern B-cell lymphomas. We report a case of systemic T-cell anaplastic large cell lymphoma CD30+ ALK- with CNS involvement at the time of diagnosis and unusual MRI characteristics resembling acute disseminated encephalomyelitis. Read More

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http://dx.doi.org/10.1016/j.msard.2017.03.003DOI Listing
April 2017
2 Reads

Potential application and prevalence of the CD30 (Ki-1) antigen among solid tumors: A focus review of the literature.

Crit Rev Oncol Hematol 2017 May 27;113:8-17. Epub 2017 Feb 27.

Hematology, Oncology, Blood & Marrow Transplantation, Department of Medicine, University of Arizona, Tucson, AZ, 85721, United States.

Background: CD30 (Ki-1) is a cell membrane protein derived from the tumor necrosis factor (TNF) receptor family. The CD30 antigen has been associated primarily with Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL). Brentuximab vedotin (BV) is an antibody-drug conjugate targeting the CD30 antigen. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2017.02.021DOI Listing
May 2017
8 Reads

CD30+ T Cells in Late Seroma May Not Be Diagnostic of Breast Implant-Associated Anaplastic Large Cell Lymphoma.

Aesthet Surg J 2017 07;37(7):771-775

Jersey Shore University Medical Center, Neptune, NJ.

The objective was to analyze and discuss the implications of a nonmalignant CD30+ late seroma. Methods included collection of seroma fluid and peripheral blood from a patient with a late seroma 22 years after initial breast reconstruction. A panel of 24 monoclonal antibodies was used to detect T-cell receptor Vβ regions present on ~70% of normal human peripheral blood T lymphocytes. Read More

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http://dx.doi.org/10.1093/asj/sjw286DOI Listing
July 2017
21 Reads

Primary cutaneous anaplastic large cell lymphoma.

J Cutan Pathol 2017 Jun 25;44(6):570-577. Epub 2017 Apr 25.

Department of Pathology, Stanford University School of Medicine, Stanford, California.

Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a CD30+ lymphoproliferative disorder (LPD) of the skin with a relatively good prognosis in the absence of high-stage disease. CD30+ LPDs comprise approximately 25%-30% of primary cutaneous lymphomas and as a group represent the second most common clonal T-cell neoplasm of the skin behind mycosis fungoides. Diagnosis of PC-ALCL relies strongly on clinicopathologic correlation given the potential morphologic, clinical and molecular overlap with the other cutaneous CD30+ LPD, lymphomatoid papulosis, and more aggressive hematolymphoid neoplasms. Read More

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http://dx.doi.org/10.1111/cup.12937DOI Listing
June 2017
11 Reads

T-Cell Lymphoma: Recent Advances in Characterization and New Opportunities for Treatment.

J Natl Cancer Inst 2017 02 31;109(2). Epub 2016 Dec 31.

Memorial Sloan-Kettering Cancer Center, New York, NY , USA.

Peripheral T-cell lymphomas (PTCLs) are uncommon, heterogeneous, and aggressive non-Hodgkin's lymphomas. Despite progress in the last several years resulting in a deeper understanding of PTCL biology and pathogenesis, there is currently no accepted single standard of care for newly diagnosed patients, and for those with relapsed or refractory disease, prognosis is dismal. The National Cancer Institute convened a Clinical Trials Planning Meeting to advance the national clinical trial agenda in lymphoma. Read More

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http://dx.doi.org/10.1093/jnci/djw248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059211PMC
February 2017
10 Reads

A new era for cutaneous CD30-positive T-cell lymphoproliferative disorders.

Authors:
Werner Kempf

Semin Diagn Pathol 2017 Jan 29;34(1):22-35. Epub 2016 Nov 29.

Kempf und Pfaltz, Histologische Diagnostik, Zürich, Switzerland; Department of Dermatology, University Hospital Zurich, CH-8091, Zurich, Switzerland. Electronic address:

Cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ T-LPD) represent a spectrum encompassing lymphomatoid papulosis (LyP), primary cutaneous anaplastic large-cell lymphoma (pcALCL) and borderline lesions. They share the expression of CD30 as a common phenotypic marker. They differ however in their clinical presentation, the histological features and clinical course. Read More

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http://dx.doi.org/10.1053/j.semdp.2016.11.005DOI Listing
January 2017
14 Reads

Diagnostic, prognostic and therapeutic role of CD30 in lymphoma.

Expert Rev Hematol 2017 Jan 21;10(1):29-37. Epub 2016 Dec 21.

a Hematology & Oncology , University of Alabama at Birmingham , Birmingham , AL , USA.

Introduction: CD30 is a cell surface receptor expressed in classical Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), and many other lymphomas to a variable degree. It has been identified as an important therapeutic target in lymphoma. Areas covered: CD30 testing is essential in diagnosis of classical HL and ALCL, and expression can also be seen in other lymphoma subtypes. Read More

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http://dx.doi.org/10.1080/17474086.2017.1270202DOI Listing
January 2017
20 Reads
5 Citations

CD30 Induces Heat Shock Protein 90 and Signal Integration in Classic Hodgkin Lymphoma Cells.

Am J Pathol 2017 Jan 19;187(1):163-175. Epub 2016 Nov 19.

Department of Hematology, School of Medicine, Kitasato University, Minami-ku, Sagamihara, Kanagawa, Japan; Division of Hematology, Department of Laboratory Sciences, School of Allied Health Sciences, Kitasato University, Minami-ku, Sagamihara, Kanagawa, Japan. Electronic address:

Previous studies report deregulation of multiple signaling pathways in classic Hodgkin lymphoma (cHL) cells. However, the mechanisms of how these pathways are integrated are not fully understood. Herein, we show involvement of cHL hallmark antigen CD30 in this process. Read More

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http://dx.doi.org/10.1016/j.ajpath.2016.09.007DOI Listing
January 2017
15 Reads

CD30+ lymphoproliferative disorder with spindle-cell morphology.

J Cutan Pathol 2016 Nov 26;43(11):1041-1044. Epub 2016 Aug 26.

Department of Pathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA.

Lymphomatoid papulosis (LyP) is classified as a CD30+ primary cutaneous lymphoproliferative disease. The phenotypic variability along the spectrum of CD30+ lymphoproliferative diseases is highlighted by the distinct histologic subtypes of LyP types A, B, C, and the more recently described types D, E, and F. We report the case of an elderly woman with a clinical presentation and histopathologic findings consistent with LyP, whose atypical CD30+ infiltrate uniquely demonstrated a spindle-cell morphology. Read More

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http://dx.doi.org/10.1111/cup.12773DOI Listing
November 2016
9 Reads

A case of CD4/CD8 double-positive primary cutaneous anaplastic large cell lymphoma of the lip involving spontaneous regression after biopsy.

Eur J Dermatol 2017 Feb;27(1):68-69

Department of Dermatology, Nara Medical University School of Medicine, 840 Shijo, Kashihara, Nara 634-8522, Japan.

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http://dx.doi.org/10.1684/ejd.2016.2899DOI Listing
February 2017
15 Reads

Therapeutic Use of Brentuximab Vedotin in CD30+ Hematologic Malignancies.

Anticancer Agents Med Chem 2017 ;17(7):886-895

Division of Hematology, University of Siena, Siena, Italy.

The CD30 antigen is strongly expressed on neoplastic cells in classical Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL) and other hematologic malignancies (such as DLBCL and cutaneous TCL), while is almost undetectable on healthy tissues, representing an ideal immunotherapeutic target. Since unconjugated anti-CD30 antibody (SGN-30) demonstrated limited clinical activity, researchers' effort aimed to create an antibody-drug conjugate (ADC), leading to discovery of SGN-35 (brentuximab vedotin), in which an anti-CD30 antibody is linked to the antimitotic agent monomethyl auristatin E (MMAE). In the first phase I study in CD30+ hematologic malignancies (the majority of patients with HL), the maximum tolerated dose was fixed respectively at 1. Read More

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http://dx.doi.org/10.2174/1871520616666160902100506DOI Listing
August 2017
43 Reads
2.470 Impact Factor

Targeting KIR3DL2 in primary cutaneous anaplastic large cell lymphomas.

Authors:
P L Ortiz-Romero

Br J Dermatol 2016 08;175(2):246-7

Servicio de Dermatología, Hospital 12 de Octubre, Universidad Complutense, Instituto i + 12, Madrid, Spain.

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http://dx.doi.org/10.1111/bjd.14783DOI Listing
August 2016
2 Reads

Loss of CD30 expression after treatment with brentuximab vedotin in a patient with anaplastic large cell lymphoma: a novel finding.

J Cutan Pathol 2016 Dec 15;43(12):1161-1166. Epub 2016 Sep 15.

Department of Pathology, Section of Dermatopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma characterized by strong and uniform expression of CD30. Brentuximab vedotin (BV), an anti-CD30 antibody-drug conjugate has been approved by the U.S. Read More

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http://dx.doi.org/10.1111/cup.12797DOI Listing
December 2016
11 Reads

Clinical Implications of CD30 Expression in Aggressive B-Cell Lymphomas.

Clin Lymphoma Myeloma Leuk 2016 08 10;16(8):429-33. Epub 2016 May 10.

Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA.

Background: US Food and Drug Administration approval of brentuximab vedotin for treatment of CD30-positive relapsed/refractory lymphomas, including classical Hodgkin lymphoma and anaplastic large cell lymphoma, initiated significant interest in researching CD30 expression in other therapy-resistant or relapsed lymphomas. We evaluated CD30 expression in 116 cases of aggressive B-cell lymphomas diagnosed at Penn State Milton S. Hershey Medical Center between 2000 and 2012 with the purpose of assessing the benefit of treatment with brentuximab. Read More

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http://dx.doi.org/10.1016/j.clml.2016.04.011DOI Listing
August 2016
5 Reads

Primary cutaneous CD30(+) lymphoproliferative disorders.

J Dtsch Dermatol Ges 2016 Aug;14(8):767-82

Department of Dermatology, The University of Texas, MD Anderson Cancer Center, Houston Texas, U.S.A.

Primary cutaneous CD30(+) lymphoproliferative disorders are the second most common group of cutaneous T-cell lymphomas (CTCL) and include lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Both disease entities share overlapping clinical, histopathological, and molecular features, thus representing a spectrum of cutaneous CD30(+) lymphoproliferative disorders. LyP may be distinguished from cALCL by clinicopathological correlation. Read More

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http://dx.doi.org/10.1111/ddg.13117DOI Listing
August 2016
6 Reads

New uses for brentuximab vedotin and novel antibody drug conjugates in lymphoma.

Expert Rev Hematol 2016 Aug 14;9(8):767-80. Epub 2016 Jul 14.

a Division of Hematology , University Hospital Ospedale di Circolo & Fondazione Macchi, University of Insubria , Varese , Italy.

Introduction: Brentuximab vedotin (BV) is a potent anti-CD30 antibody drug conjugate (ADC) that has been approved in relapsed or refractory Hodgkin lymphoma (HL) after autologous stem cell transplantation (ASCT) and anaplastic large-cell lymphoma (ALCL). Beyond these consolidated indications, BV has been tested in a number of different settings with promising results, leading for example to the recent approval as a consolidation after ASCT in high-risk HL patients.

Areas Covered: Main emerging areas of clinical investigation of BV include the use as a single-agent or in combination with bendamustine in first-salvage therapy of HL (bridge to ASCT), in the frontline setting in combination with AVD chemotherapy in HL and with CHP in ALCL, in relapsed or refractory cutaneous T-cell lymphomas and finally in diffuse large B-cell lymphomas (DLBCL) expressing CD30. Read More

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http://dx.doi.org/10.1080/17474086.2016.1205949DOI Listing
August 2016
26 Reads

Loss of CD30 Expression in Anaplastic Large Cell Lymphoma Following Brentuximab Therapy.

J Drugs Dermatol 2016 Jul;15(7):894-5

Monoclonal antibody therapy is a new innovation in cancer therapy. Binding of monoclonal antibodies to tumor cells facilitates their destruction by the immune system. Tumor cells with mutated target antigens may escape detection by monoclonal antibodies and exhibit a selective growth advantage. Read More

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July 2016
3 Reads

ALK-negative anaplastic large cell lymphoma with loss of CD30 expression during treatment with brentuximab vedotin.

Rinsho Ketsueki 2016 05;57(5):634-7

Department of Hematology and Oncology, Dokkyo Medical University School of Medicine.

A 59-year-old woman with anaplastic large cell lymphoma (ALCL), ALK-negative, was treated with brentuximab vedotin (BV) against relapse after 6 regimens of systemic chemotherapy and radiation. Despite achieving an initial response, skin lesions worsened after 11 courses. A skin biopsy after the development of resistance to BV confirmed loss of CD30 expression by the tumor cells, suggesting a possible cause of resistance. Read More

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http://dx.doi.org/10.11406/rinketsu.57.634DOI Listing
May 2016
6 Reads

Development of a primary cutaneous CD30(+) anaplastic large-cell T-cell lymphoma during treatment of multiple sclerosis with fingolimod.

Mult Scler 2016 12 26;22(14):1888-1890. Epub 2016 Apr 26.

Department of Dermatology and Venereology, Harzklinikum Dorothea Christiane Erxleben, Quedlinburg, Germany.

Background: The appearance of solid tumors und lymphomas during treatment with fingolimod was observed in studies and has been described in case reports.

Objective: To report a case of primary cutaneous CD30(+) anaplastic large-cell T-cell lymphoma during treatment of multiple sclerosis (MS) with fingolimod.

Methods: Case study. Read More

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http://dx.doi.org/10.1177/1352458516645868DOI Listing
December 2016
16 Reads

Ulcerations on the Neck and Forearm.

Ann Emerg Med 2016 May;67(5):677-83

Department of Emergency Medicine, University of Texas Southwestern Medical School, Dallas, TX.

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http://dx.doi.org/10.1016/j.annemergmed.2015.09.002DOI Listing
May 2016
7 Reads

Characterization of the tumor microenvironment in primary cutaneous CD30-positive lymphoproliferative disorders: a predominance of CD163-positive M2 macrophages.

J Cutan Pathol 2016 Jul 8;43(7):579-88. Epub 2016 May 8.

Kempf and Pfaltz Histologische Diagnostik, Zürich, Switzerland.

Background: The tumor microenvironment is essential for tumor survival, growth and progression. There are only a few studies on the tumor microenvironment in cutaneous CD30-positive lymphoproliferative disorders.

Methods: We assessed the composition of the tumor microenvironment using immunohistochemistry studies in skin biopsies from cases diagnosed with lymphomatoid papulosis (LyP: 18 specimens), primary cutaneous anaplastic large-cell lymphoma (PC-ALCL: 8 specimens), and reactive diseases harboring CD30-positive cells (18 specimens). Read More

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http://dx.doi.org/10.1111/cup.12719DOI Listing
July 2016
17 Reads

KIR3DL2 (CD158k) is a potential therapeutic target in primary cutaneous anaplastic large-cell lymphoma.

Br J Dermatol 2016 Aug 13;175(2):325-33. Epub 2016 Jul 13.

Université Paris-Diderot, Sorbonne Paris Cité, Paris, 75010, France.

Background: KIR3DL2, an inhibitory receptor expressed by natural killer cells and a subset of normal CD8(+) T cells, is aberrantly expressed in neoplastic cells in transformed mycosis fungoides and Sézary syndrome. Anti-KIR3DL2 targeted antibody therapy has shown potent activity in preclinical models for these diseases.

Objectives: To examine the expression of KIR3DL2 and its potential use as a therapeutic target in patients with primary cutaneous anaplastic large-cell lymphoma (pcALCL), the most aggressive cutaneous CD30(+) lymphoproliferative disease. Read More

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http://dx.doi.org/10.1111/bjd.14626DOI Listing
August 2016
7 Reads

A Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder Arising in a Patient With Multiple Myeloma and Cutaneous Amyloidosis.

Am J Dermatopathol 2016 May;38(5):388-92

*Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; †Department of Dermatology, Mayo Clinic, Rochester, MN, Dr. Cohen is now affiliated with the Department of Pathology and Immunology, Baylor College of Medicine, and Department of Pathology, Michael E. DeBakey Veterans Affairs Hospital, Houston, TX (As of/After July 1, 2015); ‡Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, Rochester, MN; and §Departments of Laboratory Medicine and Pathology, and Dermatology, Mayo Clinic, Rochester, MN.

CD30-positive cutaneous lymphoproliferative disorders, a group of T-cell neoplasms, including lymphomatoid papulosis (LyP) and cutaneous anaplastic large cell lymphoma, require careful clinicopathologic correlation for diagnosis. An association between LyP and the development of a second hematolymphoid malignancy has been established in the literature. LyP has also been reported with systemic amyloidosis, but no such reports have documented coexisting cutaneous amyloid deposition with LyP to our knowledge. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000534DOI Listing
May 2016
11 Reads

Complete remission of refractory disseminated NK/T cell lymphoma with brentuximab vedotin and bendamustine.

Ann Hematol 2016 Apr 2;95(5):847-9. Epub 2016 Mar 2.

Department of Medicine, Queen Mary Hospital, Professorial Block, Pokfulam Road, Hong Kong, China.

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http://dx.doi.org/10.1007/s00277-016-2627-9DOI Listing
April 2016
9 Reads

Follicular Lymphomatoid Papulosis: An Eosinophilic-Rich Follicular Subtype Masquerading as Folliculitis Clinically and Histologically.

Am J Dermatopathol 2016 Jan;38(1):e1-10

Departments of *Dermatology and Cutaneous Biology; †Surgery, Thomas Jefferson University, Philadelphia, PA; and ‡Dermatologist and Dermatopathologist, Bryn Mawr Skin and Cancer Institute, Main Line Health, Bryn Mawr, PA.

Lymphomatoid papulosis (LyP) is an uncommon CD30 lymphoproliferative disorder with a relatively excellent prognosis. Ten to twenty percent of cases, however, are associated with a lymphoma, typically systemic or cutaneous anaplastic large cell lymphoma, mycosis fungoides, or Hodgkin lymphoma. Subtypes divide LyP into infiltrate-descriptive categories along a spectrum of histological manifestation. Read More

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http://pdfs.journals.lww.com/amjdermatopathology/2016/01000/
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http://dx.doi.org/10.1097/DAD.0000000000000395DOI Listing
January 2016
20 Reads

CD30+ lymphoproliferative disorder in a patient with metastatic papillary thyroid carcinoma.

Dermatol Online J 2016 Oct 15;22(10). Epub 2016 Oct 15.

Medical School, University of California, San Diego, CA, USA.

Background CD30+ lymphoproliferative disorders are rare and may feature a wide variety of presentations that mimic other conditions. Purpose A man with metastatic papillary thyroid carcinoma to skin who subsequently developed cutaneous anaplastic large cell lymphoma is described. Methods The PubMed medical database was used to search the following terms separately and in combination: ALCL, anaplastic large cell lymphoma ALCL, cutaneous anaplastic large cell lymphoma CALCL, cutaneous t-cell lymphoma CTCL, large t-cell lymphoma LTCL, lymphoproliferative, lymphomatoid papulosis LyP, mimic, papillary, thyroid cancer. Read More

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October 2016
6 Reads

The emerging role of CD30 and p53 as novel targets for therapy in anaplastic large cell lymphoma.

Front Biosci (Elite Ed) 2016 Jan 1;8:61-71. Epub 2016 Jan 1.

Department of Pathology and Cytology, Karolinska University Hospital and Karolinska Institute, Radiumhemmet, Stockholm, Sweden SE-17176.

ALK+ anaplastic large cell lymphoma (ALCL). frequently carries the t(2;5).(p23;q35). Read More

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January 2016
5 Reads

A Single-Center Experience With Brentuximab Vedotin in Gamma Delta T-Cell Lymphoma.

Clin Lymphoma Myeloma Leuk 2016 Feb 1;16(2):e15-9. Epub 2015 Dec 1.

Department of Dermatology and Dermatopathology, University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1016/j.clml.2015.11.013DOI Listing
February 2016
10 Reads