130 results match your criteria Lymphoma High-Grade Malignant Immunoblastic


[Angioimmunoblastic T-cell lymphoma: histopathological grading and prognosis].

Zhonghua Bing Li Xue Za Zhi 2019 Oct;48(10):784-790

Department of Pathology, Changhai Hospital, Naval Military Medical University, Shanghai 200433, China.

To investigate the histological features and prognostic factors of angioimmunoblastic T-cell lymphoma (AITL). The pathological data of 62 patients with AITL with complete follow-up information were retrospectively collected and analyzed from Changhai Hospital during September 2012 and September 2017. Histological and immunohistochemical (IHC) examination, in situ hybridization (ISH), and single nucleotide polymorphisms (SNP) gene mutation analysis were done. Read More

View Article and Full-Text PDF
October 2019

Plasmablastic lymphoma may occur as a high-grade transformation from plasmacytoma.

Exp Mol Pathol 2011 Feb 19;90(1):85-90. Epub 2010 Oct 19.

Department of Pathology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA.

Plasmablastic lymphoma (PBL) is an uncommon aggressive lymphoma arising most frequently in the oral cavity of HIV-infected patients. Rare cases of PBL have been reported in extraoral sites, particularly extranodal sites, as well as in immunocompetent patients. We report an unusual case of PBL in a 69-year-old, HIV-negative non-immunocompromised man presenting with generalized lymphadenopathy. Read More

View Article and Full-Text PDF
February 2011

Plasmablastic lymphoma involving the parotid gland.

Head Neck Pathol 2010 Jun 27;4(2):148-51. Epub 2010 Feb 27.

Department of Pathology, The Johns Hopkins Medical Institutions, 600 N. Wolfe St., Baltimore, MD 21287, USA.

Plasmablastic lymphoma is a rare form of non-Hodgkin lymphoma. It is strongly associated with HIV infection, although it has been recognized in immunocompetent patients. Plasmablastic lymphoma has a predilection for the oral cavity. Read More

View Article and Full-Text PDF

A morphological study of 608 cases of canine malignant lymphoma in France with a focus on comparative similarities between canine and human lymphoma morphology.

Vet Pathol 2010 May;47(3):414-33

Laboratoire de Pathologie Clinique et Unité d'Oncologie, Ecole Nationale Vétérinaire de Lyon, 1 Avenue Bourgelat, 69280 Marcy L'Etoile, France.

This study reports cytomorphological, histomorphological, and immunological characterization of 608 biopsy cases of canine malignant lymphoma, with epidemiological and clinical data, collected from 7 French veterinary pathology laboratories. It compares morphological characteristics of malignant lymphoma in canines, per the updated Kiel classification system, with those reported in humans, per the World Health Organization (WHO) classification system. Of tumors described, 24. Read More

View Article and Full-Text PDF

Serous effusions in malignant lymphomas: a review.

Authors:
Dilip K Das

Diagn Cytopathol 2006 May;34(5):335-47

Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait.

Serous effusions are a common complication of lymphomas. Although the frequency of pleural effusion is 20-30% in non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD), the involvement of peritoneal and pericardial cavities is uncommon. Among lymphoma subtypes, T-cell neoplasms, especially the lymphoblastic lymphomas, more frequently involve the serous fluids. Read More

View Article and Full-Text PDF

Etiology and pathogenesis of AIDS-related non-Hodgkin's lymphoma.

Authors:
Daniel M Knowles

Hematol Oncol Clin North Am 2003 Jun;17(3):785-820

Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA.

The incidence of NHL is greatly increased in HIV-infected individuals; malignant lymphoma is the second most common neoplasm that occurs in association with AIDS. The vast majority of neoplasms are clinically aggressive, monoclonal B-cell neoplasms that exhibit Burkitt's, immunoblastic, large cell, or transitional histopathology. Approximately 80% arise systemically (nodal or extranodal) and 20% arise as primary CNS lymphomas. Read More

View Article and Full-Text PDF

Emerging pathways in the development of AIDS-related lymphomas.

Authors:
Antonino Carbone

Lancet Oncol 2003 Jan;4(1):22-9

Centro di Riferimento Oncologico-IRCCS, Aviano, Italy.

The clinicopathological range of AIDS-related non-Hodgkin lymphomas (NHLs) includes systemic lymphomas, primary central-nervous-system lymphomas, primary effusion lymphoma, and plasmablastic lymphoma of the oral cavity. Most AIDS-related NHLs belong to one of three categories of high-grade B-cell lymphomas: Burkitt's lymphoma, centroblastic lymphoma, and immunoblastic lymphoma. The pathological heterogeneity of AIDS-related NHL reflects the heterogeneity of their associated molecular lesions. Read More

View Article and Full-Text PDF
January 2003

Incidence of primary extranodal lymphoma involving gastrointestinal tract by histological type at Ilorin.

Niger J Med 2001 Jul-Sep;10(3):135-8

Department of Morbid Anatomy and Histopathology, University of Ilorin Teaching Hospital, Ilorin, Nigeria.

We report 21 cases of primary extranodal lymphoma of the gastrointestinal tract over a period of 10 years (1986-1995) at the Department of Morbid Anatomy and Histopathology, University of Ilorin Teaching Hospital, Ilorin, Kwara State of Nigeria. This represents 6% of the total gastrointestinal tract malignancies diagnosed during same period. All were Non Hodgkin's Lymphoma. Read More

View Article and Full-Text PDF
February 2002

A man with hereditary exostoses and high-grade non-Hodgkin's lymphoma of the bone.

Ann Hematol 2001 Nov;80(11):682-4

Department of Internal Medicine V, University of Heidelberg, Germany.

Multiple cartilaginous exostoses (MCE) is an autosomal dominant disorder that can lead to malignant transformation from exostoses to a secondary chondrosarcoma. We present a case report of a 52-year-old man with MCE who had a palpable mass at the left shoulder. At the site of the left proximal humerus, a cartilaginous exostosis was localized, suggesting that the tumor developed by a malignant transformation of an exostosis into a secondary chondrosarcoma. Read More

View Article and Full-Text PDF
November 2001

[Allogeneic transplantation in malignant lymphoma].

Dtsch Med Wochenschr 2001 Sep;126(39):1062-9

Medizinische Klinik III der Ludwig-Maximilians-Universität München, Grosshadern.

Introduction: Allogeneic transplantation of bone marrow and peripheral blood stem cells is a frequently discussed therapeutic option in the treatment of malignant lymphoma. By analysing the results of our own transplant program in patients with advanced lymphoma we tried to evaluate indications for allogeneic transplantations.

Methods: Data from lymphoma patients treated at the Klinikum Grosshadern between 1985 and 2001 were analysed retrospectively. Read More

View Article and Full-Text PDF
September 2001

Expression of the simian Epstein-Barr virus-encoded latent membrane protein-1 in malignant lymphomas of SIV-infected rhesus macaques.

J Med Virol 2001 Sep;65(1):114-20

Department of Nephrology and Rheumatology, University of Göttingen, Göttingen, Germany.

During the course of simian immunodeficiency virus (SIV) infection, nearly 15% of rhesus macaques (Macaca mulatta) and up to 40% of cynomolgus macaques (Macaca fascicularis) developed SIV-associated non-Hodgkin's lymphomas. Most of these malignant lymphomas harbored lymphocryptoviruses, which are closely related to the human Epstein-Barr virus (EBV; Herpesvirus M. mulatta and Herpesvirus M. Read More

View Article and Full-Text PDF
September 2001

Primary non-Hodgkin's lymphoma of the jaws: immunohistochemical and genetic review of 10 cases.

J Oral Maxillofac Surg 2000 Jun;58(6):636-44

Department of Oral and Maxillofacial Surgery, University of Verona, Faculty of Medicine, Italy.

Purpose: Non-Hodgkin's lymphoma (NHL) comprises a group of malignant lymphoproliferative diseases characterized by clonal expansion of lymphocytes at various levels of ontogenetic development. The aim of this study was to review the immunohistochemical and cytogenetic features of 10 cases of NLH of the jaws to determine their respective derivation.

Patients And Methods: Histopathologic and immunohistochemical review of 10 cases of large-cell lymphomas of the jaws, together with Southern blot analysis of 2 of the cases, was performed and results compared with the findings in the literature. Read More

View Article and Full-Text PDF

Primary malignant lymphoma of the duodenum: report of a case.

Hepatogastroenterology 1998 Nov-Dec;45(24):2171-4

Department of Surgery, Yokote Public Hospital, Akita University School of Medicine, Japan.

We present a case of long-term survival in primary malignant lymphoma of the duodenum treated with a curative surgical resection and post-operative chemotherapy. A 72 year-old man was admitted to our hospital complaining of epigastric discomfort. Endoscopy revealed an ulcerative tumor in the duodenal bulb. Read More

View Article and Full-Text PDF

Abundance of heat shock proteins (hsp89, hsp60, and hsp27) in malignant cells of Hodgkin's disease.

Authors:
P L Hsu S M Hsu

Cancer Res 1998 Dec;58(23):5507-13

Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, USA.

Heat shock proteins (HSPs) or stress proteins are synthesized by cells in response to environmental stress. Expression of HSPs by cells may have important physiological or pathological implications. In this study, we carried out an immunohistochemical and biochemical examination of low (hsp27), intermediate (hsp60), and high (hsp89) molecular weight HSP expression in reactive lymph nodes and in lymph nodes of patients with various types of lymphomas. Read More

View Article and Full-Text PDF
December 1998

[Diagnostic and prognostic value of interleukin-6 in malignant non-Hodgkin's lymphomas].

Vestn Ross Akad Med Nauk 1998 (10):32-6

Sixty six patients with non-Hodgkin's lymphomas (NHL) were studied, interleukin-6 (IL-6) was revealed in the blood sera of 33 patients. IL-6 was revealed more frequently in patients with high-grade malignant (p < 0.05) than in those with low-grade malignancy. Read More

View Article and Full-Text PDF
January 1999

A case of primary bone lymphoma associated with acquired immunodeficiency syndrome.

Yonsei Med J 1998 Aug;39(4):383-9

Division of Infectious Diseases, Yonsei University College of Medicine, Seoul, Korea.

A 33-year old man with acquired immunodeficiency syndrome was admitted to Severance hospital following 1 year of diarrhea and 2 to 3 months of low sternal pain. The patient had progressive generalized lymphadenopathy for the previous 3 years. Whole body bone scan for evaluation of bone pain showed multiple abnormal hot uptakes at the low sternal body and T8 and T10 vertebra. Read More

View Article and Full-Text PDF

Malignant lymphoma in Thailand: changes in the frequency of malignant lymphoma determined from a histopathologic and immunophenotypic analysis of 425 cases at Siriraj Hospital.

Cancer 1998 Sep;83(6):1197-204

Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Analysis of malignant lymphoma in a single institution at different periods of time can determine the changing status of the disease in the region.

Methods: To compare with the large series of 1095 lymphoma cases reported between 1957-1971 at Siriraj Hospital, the largest hospital in Thailand, a similar study was performed through histopathologic evaluation of 425 lymphoma cases diagnosed consecutively at the same institution between August 1993 and October 1995. Phenotypic analysis was performed by paraffin section-immunoperoxidase studies. Read More

View Article and Full-Text PDF
September 1998

[Comparison of chemotherapy CHOP vs. CHOP/VIA in the treatment of aggressive non-Hodgkin's lymphoma: a randomized multicenter study of 132 patients. The PETHEMA group. Program for Study and Therapeutics of malignant hemopathies. Spanish Association of Hematology and Hemotherapy].

Med Clin (Barc) 1998 May;110(16):601-4

Servicio de Hematología, Hospital Clínic i Provincial, Villarroel, Barcelona.

Background: To compare standard chemotherapy CHOP (cyclophosphamide, adriamycin, vincristine and prednisone) with the regimen CHOP/VIA (VP-16, iphosphamide and cytarabine) in terms of response to therapy, response duration, survival and toxicity in patients with aggressive lymphoma.

Patients And Methods: 132 patients (84 males and 48 females; median age, 55 years) were included from 12 Spanish Institutions, diagnosed of non-Hodgkin's lymphoma of intermediate or high grade, in stages II-IV and previously untreated. Patients were randomized to receive CHOP or CHOP/VIA. Read More

View Article and Full-Text PDF

Non-Hodgkin lymphoma and Kaposi sarcoma in an eyelid of a patient with acquired immunodeficiency syndrome. Multiple viruses in pathogenesis.

Arch Ophthalmol 1997 Nov;115(11):1464-6

Department of Ophthalmology, University of California, San Francisco, USA.

A 36-year-old patient with acquired immunodeficiency syndrome sought care because of an upper eyelid lesion that dramatically increased in size. The histopathologic examination revealed a high-grade diffuse large cell non-Hodgkin lymphoma in continuity with a Kaposi sarcoma. In situ hybridization revealed Epstein-Barr virus in the large cell lymphoma and Kaposi sarcoma-associated herpesvirus in the Kaposi sarcoma lesion. Read More

View Article and Full-Text PDF
November 1997

[3 cases of malignant immunoblastic lymphomas].

Rev Med Chir Soc Med Nat Iasi 1997 Jul-Dec;101(3-4):205-8

Disciplina de Histologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.

Immunoblastic malignant lymphomas belong to the high-grade malignant lymphomas and can be classified into B and T types, according to the origin line of the proliferating cells. This paper presents three cases of immunoblastic malignant lymphomas, exhibiting fairly close morphological aspects. The morphological diagnosis based on standard methods using conventional dyes was supplemented by immunohistochemical diagnosis with monoclonal antibodies. Read More

View Article and Full-Text PDF

Posttransplantation lymphoproliferative disorders in bone marrow transplant recipients are aggressive diseases with a high incidence of adverse histologic and immunobiologic features.

Am J Clin Pathol 1997 Apr;107(4):419-29

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA.

Posttransplantation lymphoproliferative disorders (PT-LPDs) occurring in T-cell depleted (TCD) allogeneic bone marrow transplant recipients seem to be different from those that arise in solid organ recipients in their early development, the high incidence of extensive dissemination at presentation, and their aggressive course and high fatality rate. We report a series of 10 patients with PT-LPDs after TCD allogeneic bone marrow transplant. We studied the correlation between the morphology of the lesions; their clonality based on immunoglobulin (Ig) heavy chain gene rearrangement analysis and immunohistochemistry; their proliferative activity as measured by immunoperoxidase staining for the proliferating cell nuclear antigen (PCNA) and the presence of p53 gene product overexpression. Read More

View Article and Full-Text PDF

Subclassification of diffuse large B-cell lymphomas according to the Kiel classification: distinction of centroblastic and immunoblastic lymphomas is a significant prognostic risk factor.

Blood 1997 Apr;89(7):2291-7

Department of Medicine, Hematology, Universitätsklinikum Essen, Germany.

Among high-grade malignant non-Hodgkin's lymphomas the updated Kiel classification identifies three major B-cell entities: centroblastic (CB), B-immunoblastic (B-IB), and B-large cell anaplastic (Ki-1+) (now termed anaplastic large cell [CD30+], [B-ALC]). The clinical prognostic relevance of this distinction was evaluated in a randomized prospective treatment trial (COP-BLAM/IMVP-16 regimen randomly combined +/- radiotherapy in complete responders) conducted in adult (age 15 to 75) patients with Ann Arbor stage II-IV disease (n = 219) diagnosed by optimal histomorphology (Giemsa staining) and by immunohistochemistry. Overall survival was significantly better in CB lymphoma as compared to B-IB (P = . Read More

View Article and Full-Text PDF

Molecular pathology of acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma.

Authors:
D M Knowles

Semin Diagn Pathol 1997 Feb;14(1):67-82

Department of Pathology, New York Hospital, Cornell Medical Center, New York 10021, USA.

The incidence of non-Hodgkin's lymphoma is greatly increased in human immunodeficiency virus (HIV)-infected individuals. Most are clinically aggressive B-cell lymphomas exhibiting Burkitt-type, immunoblastic or large-cell morphology. Approximately 80% arise systemically (nodal or extranodal), and the remaining 20% arise in the central nervous system. Read More

View Article and Full-Text PDF
February 1997

Malignant gastrointestinal lymphomas in patients with AIDS.

Digestion 1997 ;58(3):218-24

Department of Gastroenterology and Infectious Diseases, Anguste Viktoria Hospital, Berlin, Germany.

HIV-associated malignant lymphomas are a common complication in late HIV infection, and there is a high percentage of gastrointestinal tract involvement. Non-Hodgkin's lymphoma was found in 108 of 2,750 HIV-positive patients (3.9%) in our institution, whereas gastrointestinal manifestation was diagnosed in 48 of 108 patients (44. Read More

View Article and Full-Text PDF
September 1997

[Morpho-immunologic phenotypes of T-cell non-Hodgkin's malignant lymphoma in baboons and their connection with with T-lymphotropic retrovirus STLV-1].

Arkh Patol 1997 Jan-Feb;59(1):19-25

Max von Pettenkofer Institute, Munchen, Germany.

8 cytological types were detected among 58 cases of T-NHL of Papio hamadryas according to human updated Kiel classification (1988). 5 of them were of low grade (lymphocytic, prolymphocytic, T-zone, angioimmunoblastic, small cell pleomorphic) and 3-of high grade (medium and large cell pleomorphic, immunoblastic, large cell anaplastic CD30/Ki-1+). There are differences in a tumor structure and generalization in baboon and human lymphomas in spite of significant similarities. Read More

View Article and Full-Text PDF

Primary effusion lymphoma in women: report of two cases of Kaposi's sarcoma herpes virus-associated effusion-based lymphoma in human immunodeficiency virus-negative women.

Blood 1996 Oct;88(8):3124-8

Department of Pathology, Cedars Sinai Medical Center, School of Medicine 90048, USA.

Recent molecular evidence suggests an association with a new herpes virus, Kaposi's sarcoma-associated herpes virus (KSHV/HHV-8), and primary effusion lymphomas (PEL). PELs have a characteristic morphology, phenotype, and clinical presentation with malignant effusions in the absence of a contiguous solid tumor mass. Most cases of PEL have occurred in human immunodeficiency virus (HIV)-positive male patients who are coinfected with Epstein-Barr virus (EBV). Read More

View Article and Full-Text PDF
October 1996

[Primary cerebral non-Hodgkin's lymphomas and primary malignant brain tumors in a well-defined geographical area. Population-based data from the registry of non-Hodgkin's lymphoma in western Denmark, LYFO and the cancer registry, Kraeftens Bekaempelse].

Ugeskr Laeger 1996 Jul;158(31):4406-12

Aalborg Sygehus Syd, medicinsk-haematologisk afdeling og onkologisk afdeling.

In a Danish population-based non-Hodgkin's lymphoma (NHL) registry (LYFO) representing a population of 2.7 million all new cases of NHL were registered from 1st January 1983 to 31st May 1994. Incidence data of primary malignant tumours of the brain and central nervous system in western Denmark for the period 1971-1990 have been obtained from the Danish Cancer Registry. Read More

View Article and Full-Text PDF

Histologic classification and immunophenotype of lymphosarcomas in cats with naturally and experimentally acquired feline immunodeficiency virus infections.

Vet Pathol 1996 May;33(3):264-72

Department of Veterinary Pathology, University of Glasgow, Bearsden, UK.

Lymphosarcoma (malignant lymphoma) is the commonest hematopoietic tumor in the cat. Many cases are associated with feline leukemia virus (FeLV) infection, but epidemiologic and experimental data suggest that feline immunodeficiency virus (FIV) may also have a role in lymphomagenesis. In this paper, we describe the clinical presentation, histologic classification, and immunophenotype of lymphosarcoma in eight domestic cats with natural or experimental FIV infections. Read More

View Article and Full-Text PDF

Primary body cavity-based AIDS-related lymphomas.

Am J Clin Pathol 1996 Feb;105(2):221-9

Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072, USA.

Five patients with advanced AIDS developed a unique type of high grade primary body cavity-based non-Hodgkin's lymphoma (NHL). The lymphomas were exclusively in serous effusions with no detectable mass disease in the body cavities and no lymphadenopathy or organomegaly. All of the lymphomas exhibited virtually identical morphology, which could not be precisely classified, but appeared to bridge features of large cell immunoblastic and anaplastic large cell lymphomas. Read More

View Article and Full-Text PDF
February 1996

Expression of bcl-2 oncogene product in primary non-Hodgkin's malignant lymphoma of the oral cavity.

Pathol Res Pract 1996 Jan;192(1):44-53

Department of Oral Pathology, Nagasaki University School of Dentistry, Japan.

The B-cell leukemia/lymphoma-2 (bcl-2) proto-oncogene is peculiar, as its product appears to provide survival advantage to B cells by blocking apoptosis. Expression of bcl-2 protein was analyzed in 54 cases of primary non-Hodgkin's malignant lymphomas of the oral cavity by immunohistologic staining of paraffin-embedded tissue. The immunophenotype of each tumor was established with the use of a panel of monoclonal and polyclonal antibodies to lymphoid cell differentiation antigens. Read More

View Article and Full-Text PDF
January 1996