129 results match your criteria Lymphoma High-Grade Malignant Immunoblastic


Plasmablastic lymphoma may occur as a high-grade transformation from plasmacytoma.

Exp Mol Pathol 2011 Feb 19;90(1):85-90. Epub 2010 Oct 19.

Department of Pathology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA.

Plasmablastic lymphoma (PBL) is an uncommon aggressive lymphoma arising most frequently in the oral cavity of HIV-infected patients. Rare cases of PBL have been reported in extraoral sites, particularly extranodal sites, as well as in immunocompetent patients. We report an unusual case of PBL in a 69-year-old, HIV-negative non-immunocompromised man presenting with generalized lymphadenopathy. Read More

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http://dx.doi.org/10.1016/j.yexmp.2010.10.007DOI Listing
February 2011
3 Reads

Plasmablastic lymphoma involving the parotid gland.

Head Neck Pathol 2010 Jun 27;4(2):148-51. Epub 2010 Feb 27.

Department of Pathology, The Johns Hopkins Medical Institutions, 600 N. Wolfe St., Baltimore, MD 21287, USA.

Plasmablastic lymphoma is a rare form of non-Hodgkin lymphoma. It is strongly associated with HIV infection, although it has been recognized in immunocompetent patients. Plasmablastic lymphoma has a predilection for the oral cavity. Read More

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http://dx.doi.org/10.1007/s12105-010-0168-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878619PMC
June 2010
8 Reads

A morphological study of 608 cases of canine malignant lymphoma in France with a focus on comparative similarities between canine and human lymphoma morphology.

Vet Pathol 2010 May;47(3):414-33

Laboratoire de Pathologie Clinique et Unité d'Oncologie, Ecole Nationale Vétérinaire de Lyon, 1 Avenue Bourgelat, 69280 Marcy L'Etoile, France.

This study reports cytomorphological, histomorphological, and immunological characterization of 608 biopsy cases of canine malignant lymphoma, with epidemiological and clinical data, collected from 7 French veterinary pathology laboratories. It compares morphological characteristics of malignant lymphoma in canines, per the updated Kiel classification system, with those reported in humans, per the World Health Organization (WHO) classification system. Of tumors described, 24. Read More

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http://vet.sagepub.com/content/47/3/414.full.pdf
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http://vet.sagepub.com/lookup/doi/10.1177/0300985810363902
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http://dx.doi.org/10.1177/0300985810363902DOI Listing
May 2010
4 Reads

Serous effusions in malignant lymphomas: a review.

Authors:
Dilip K Das

Diagn Cytopathol 2006 May;34(5):335-47

Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait.

Serous effusions are a common complication of lymphomas. Although the frequency of pleural effusion is 20-30% in non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD), the involvement of peritoneal and pericardial cavities is uncommon. Among lymphoma subtypes, T-cell neoplasms, especially the lymphoblastic lymphomas, more frequently involve the serous fluids. Read More

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http://dx.doi.org/10.1002/dc.20432DOI Listing
May 2006
12 Reads

Etiology and pathogenesis of AIDS-related non-Hodgkin's lymphoma.

Authors:
Daniel M Knowles

Hematol Oncol Clin North Am 2003 Jun;17(3):785-820

Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA.

The incidence of NHL is greatly increased in HIV-infected individuals; malignant lymphoma is the second most common neoplasm that occurs in association with AIDS. The vast majority of neoplasms are clinically aggressive, monoclonal B-cell neoplasms that exhibit Burkitt's, immunoblastic, large cell, or transitional histopathology. Approximately 80% arise systemically (nodal or extranodal) and 20% arise as primary CNS lymphomas. Read More

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June 2003
4 Reads

Emerging pathways in the development of AIDS-related lymphomas.

Authors:
Antonino Carbone

Lancet Oncol 2003 Jan;4(1):22-9

Centro di Riferimento Oncologico-IRCCS, Aviano, Italy.

The clinicopathological range of AIDS-related non-Hodgkin lymphomas (NHLs) includes systemic lymphomas, primary central-nervous-system lymphomas, primary effusion lymphoma, and plasmablastic lymphoma of the oral cavity. Most AIDS-related NHLs belong to one of three categories of high-grade B-cell lymphomas: Burkitt's lymphoma, centroblastic lymphoma, and immunoblastic lymphoma. The pathological heterogeneity of AIDS-related NHL reflects the heterogeneity of their associated molecular lesions. Read More

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January 2003
3 Reads

Incidence of primary extranodal lymphoma involving gastrointestinal tract by histological type at Ilorin.

Niger J Med 2001 Jul-Sep;10(3):135-8

Department of Morbid Anatomy and Histopathology, University of Ilorin Teaching Hospital, Ilorin, Nigeria.

We report 21 cases of primary extranodal lymphoma of the gastrointestinal tract over a period of 10 years (1986-1995) at the Department of Morbid Anatomy and Histopathology, University of Ilorin Teaching Hospital, Ilorin, Kwara State of Nigeria. This represents 6% of the total gastrointestinal tract malignancies diagnosed during same period. All were Non Hodgkin's Lymphoma. Read More

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February 2002
6 Reads

A man with hereditary exostoses and high-grade non-Hodgkin's lymphoma of the bone.

Ann Hematol 2001 Nov;80(11):682-4

Department of Internal Medicine V, University of Heidelberg, Germany.

Multiple cartilaginous exostoses (MCE) is an autosomal dominant disorder that can lead to malignant transformation from exostoses to a secondary chondrosarcoma. We present a case report of a 52-year-old man with MCE who had a palpable mass at the left shoulder. At the site of the left proximal humerus, a cartilaginous exostosis was localized, suggesting that the tumor developed by a malignant transformation of an exostosis into a secondary chondrosarcoma. Read More

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November 2001
4 Reads

[Allogeneic transplantation in malignant lymphoma].

Dtsch Med Wochenschr 2001 Sep;126(39):1062-9

Medizinische Klinik III der Ludwig-Maximilians-Universität München, Grosshadern.

Introduction: Allogeneic transplantation of bone marrow and peripheral blood stem cells is a frequently discussed therapeutic option in the treatment of malignant lymphoma. By analysing the results of our own transplant program in patients with advanced lymphoma we tried to evaluate indications for allogeneic transplantations.

Methods: Data from lymphoma patients treated at the Klinikum Grosshadern between 1985 and 2001 were analysed retrospectively. Read More

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http://dx.doi.org/10.1055/s-2001-17492DOI Listing
September 2001
5 Reads

Expression of the simian Epstein-Barr virus-encoded latent membrane protein-1 in malignant lymphomas of SIV-infected rhesus macaques.

J Med Virol 2001 Sep;65(1):114-20

Department of Nephrology and Rheumatology, University of Göttingen, Göttingen, Germany.

During the course of simian immunodeficiency virus (SIV) infection, nearly 15% of rhesus macaques (Macaca mulatta) and up to 40% of cynomolgus macaques (Macaca fascicularis) developed SIV-associated non-Hodgkin's lymphomas. Most of these malignant lymphomas harbored lymphocryptoviruses, which are closely related to the human Epstein-Barr virus (EBV; Herpesvirus M. mulatta and Herpesvirus M. Read More

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September 2001
5 Reads

Primary non-Hodgkin's lymphoma of the jaws: immunohistochemical and genetic review of 10 cases.

J Oral Maxillofac Surg 2000 Jun;58(6):636-44

Department of Oral and Maxillofacial Surgery, University of Verona, Faculty of Medicine, Italy.

Purpose: Non-Hodgkin's lymphoma (NHL) comprises a group of malignant lymphoproliferative diseases characterized by clonal expansion of lymphocytes at various levels of ontogenetic development. The aim of this study was to review the immunohistochemical and cytogenetic features of 10 cases of NLH of the jaws to determine their respective derivation.

Patients And Methods: Histopathologic and immunohistochemical review of 10 cases of large-cell lymphomas of the jaws, together with Southern blot analysis of 2 of the cases, was performed and results compared with the findings in the literature. Read More

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June 2000
3 Reads

Primary malignant lymphoma of the duodenum: report of a case.

Hepatogastroenterology 1998 Nov-Dec;45(24):2171-4

Department of Surgery, Yokote Public Hospital, Akita University School of Medicine, Japan.

We present a case of long-term survival in primary malignant lymphoma of the duodenum treated with a curative surgical resection and post-operative chemotherapy. A 72 year-old man was admitted to our hospital complaining of epigastric discomfort. Endoscopy revealed an ulcerative tumor in the duodenal bulb. Read More

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May 1999
5 Reads

Abundance of heat shock proteins (hsp89, hsp60, and hsp27) in malignant cells of Hodgkin's disease.

Authors:
P L Hsu S M Hsu

Cancer Res 1998 Dec;58(23):5507-13

Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, USA.

Heat shock proteins (HSPs) or stress proteins are synthesized by cells in response to environmental stress. Expression of HSPs by cells may have important physiological or pathological implications. In this study, we carried out an immunohistochemical and biochemical examination of low (hsp27), intermediate (hsp60), and high (hsp89) molecular weight HSP expression in reactive lymph nodes and in lymph nodes of patients with various types of lymphomas. Read More

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December 1998
3 Reads

[Diagnostic and prognostic value of interleukin-6 in malignant non-Hodgkin's lymphomas].

Vestn Ross Akad Med Nauk 1998 (10):32-6

Sixty six patients with non-Hodgkin's lymphomas (NHL) were studied, interleukin-6 (IL-6) was revealed in the blood sera of 33 patients. IL-6 was revealed more frequently in patients with high-grade malignant (p < 0.05) than in those with low-grade malignancy. Read More

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January 1999
4 Reads

A case of primary bone lymphoma associated with acquired immunodeficiency syndrome.

Yonsei Med J 1998 Aug;39(4):383-9

Division of Infectious Diseases, Yonsei University College of Medicine, Seoul, Korea.

A 33-year old man with acquired immunodeficiency syndrome was admitted to Severance hospital following 1 year of diarrhea and 2 to 3 months of low sternal pain. The patient had progressive generalized lymphadenopathy for the previous 3 years. Whole body bone scan for evaluation of bone pain showed multiple abnormal hot uptakes at the low sternal body and T8 and T10 vertebra. Read More

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http://synapse.koreamed.org/Synapse/Data/PDFData/0069YMJ/ymj
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http://synapse.koreamed.org/DOIx.php?id=10.3349/ymj.1998.39.
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http://dx.doi.org/10.3349/ymj.1998.39.4.383DOI Listing
August 1998
4 Reads

Malignant lymphoma in Thailand: changes in the frequency of malignant lymphoma determined from a histopathologic and immunophenotypic analysis of 425 cases at Siriraj Hospital.

Cancer 1998 Sep;83(6):1197-204

Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Analysis of malignant lymphoma in a single institution at different periods of time can determine the changing status of the disease in the region.

Methods: To compare with the large series of 1095 lymphoma cases reported between 1957-1971 at Siriraj Hospital, the largest hospital in Thailand, a similar study was performed through histopathologic evaluation of 425 lymphoma cases diagnosed consecutively at the same institution between August 1993 and October 1995. Phenotypic analysis was performed by paraffin section-immunoperoxidase studies. Read More

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September 1998
6 Reads

[Comparison of chemotherapy CHOP vs. CHOP/VIA in the treatment of aggressive non-Hodgkin's lymphoma: a randomized multicenter study of 132 patients. The PETHEMA group. Program for Study and Therapeutics of malignant hemopathies. Spanish Association of Hematology and Hemotherapy].

Med Clin (Barc) 1998 May;110(16):601-4

Servicio de Hematología, Hospital Clínic i Provincial, Villarroel, Barcelona.

Background: To compare standard chemotherapy CHOP (cyclophosphamide, adriamycin, vincristine and prednisone) with the regimen CHOP/VIA (VP-16, iphosphamide and cytarabine) in terms of response to therapy, response duration, survival and toxicity in patients with aggressive lymphoma.

Patients And Methods: 132 patients (84 males and 48 females; median age, 55 years) were included from 12 Spanish Institutions, diagnosed of non-Hodgkin's lymphoma of intermediate or high grade, in stages II-IV and previously untreated. Patients were randomized to receive CHOP or CHOP/VIA. Read More

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May 1998
3 Reads

Non-Hodgkin lymphoma and Kaposi sarcoma in an eyelid of a patient with acquired immunodeficiency syndrome. Multiple viruses in pathogenesis.

Arch Ophthalmol 1997 Nov;115(11):1464-6

Department of Ophthalmology, University of California, San Francisco, USA.

A 36-year-old patient with acquired immunodeficiency syndrome sought care because of an upper eyelid lesion that dramatically increased in size. The histopathologic examination revealed a high-grade diffuse large cell non-Hodgkin lymphoma in continuity with a Kaposi sarcoma. In situ hybridization revealed Epstein-Barr virus in the large cell lymphoma and Kaposi sarcoma-associated herpesvirus in the Kaposi sarcoma lesion. Read More

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November 1997
6 Reads

[3 cases of malignant immunoblastic lymphomas].

Rev Med Chir Soc Med Nat Iasi 1997 Jul-Dec;101(3-4):205-8

Disciplina de Histologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.

Immunoblastic malignant lymphomas belong to the high-grade malignant lymphomas and can be classified into B and T types, according to the origin line of the proliferating cells. This paper presents three cases of immunoblastic malignant lymphomas, exhibiting fairly close morphological aspects. The morphological diagnosis based on standard methods using conventional dyes was supplemented by immunohistochemical diagnosis with monoclonal antibodies. Read More

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May 2000
2 Reads

Posttransplantation lymphoproliferative disorders in bone marrow transplant recipients are aggressive diseases with a high incidence of adverse histologic and immunobiologic features.

Am J Clin Pathol 1997 Apr;107(4):419-29

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA.

Posttransplantation lymphoproliferative disorders (PT-LPDs) occurring in T-cell depleted (TCD) allogeneic bone marrow transplant recipients seem to be different from those that arise in solid organ recipients in their early development, the high incidence of extensive dissemination at presentation, and their aggressive course and high fatality rate. We report a series of 10 patients with PT-LPDs after TCD allogeneic bone marrow transplant. We studied the correlation between the morphology of the lesions; their clonality based on immunoglobulin (Ig) heavy chain gene rearrangement analysis and immunohistochemistry; their proliferative activity as measured by immunoperoxidase staining for the proliferating cell nuclear antigen (PCNA) and the presence of p53 gene product overexpression. Read More

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April 1997
4 Reads

Subclassification of diffuse large B-cell lymphomas according to the Kiel classification: distinction of centroblastic and immunoblastic lymphomas is a significant prognostic risk factor.

Blood 1997 Apr;89(7):2291-7

Department of Medicine, Hematology, Universitätsklinikum Essen, Germany.

Among high-grade malignant non-Hodgkin's lymphomas the updated Kiel classification identifies three major B-cell entities: centroblastic (CB), B-immunoblastic (B-IB), and B-large cell anaplastic (Ki-1+) (now termed anaplastic large cell [CD30+], [B-ALC]). The clinical prognostic relevance of this distinction was evaluated in a randomized prospective treatment trial (COP-BLAM/IMVP-16 regimen randomly combined +/- radiotherapy in complete responders) conducted in adult (age 15 to 75) patients with Ann Arbor stage II-IV disease (n = 219) diagnosed by optimal histomorphology (Giemsa staining) and by immunohistochemistry. Overall survival was significantly better in CB lymphoma as compared to B-IB (P = . Read More

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April 1997
4 Reads

Molecular pathology of acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma.

Authors:
D M Knowles

Semin Diagn Pathol 1997 Feb;14(1):67-82

Department of Pathology, New York Hospital, Cornell Medical Center, New York 10021, USA.

The incidence of non-Hodgkin's lymphoma is greatly increased in human immunodeficiency virus (HIV)-infected individuals. Most are clinically aggressive B-cell lymphomas exhibiting Burkitt-type, immunoblastic or large-cell morphology. Approximately 80% arise systemically (nodal or extranodal), and the remaining 20% arise in the central nervous system. Read More

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February 1997
5 Reads

Malignant gastrointestinal lymphomas in patients with AIDS.

Digestion 1997 ;58(3):218-24

Department of Gastroenterology and Infectious Diseases, Anguste Viktoria Hospital, Berlin, Germany.

HIV-associated malignant lymphomas are a common complication in late HIV infection, and there is a high percentage of gastrointestinal tract involvement. Non-Hodgkin's lymphoma was found in 108 of 2,750 HIV-positive patients (3.9%) in our institution, whereas gastrointestinal manifestation was diagnosed in 48 of 108 patients (44. Read More

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http://dx.doi.org/10.1159/000201447DOI Listing
September 1997
4 Reads

[Morpho-immunologic phenotypes of T-cell non-Hodgkin's malignant lymphoma in baboons and their connection with with T-lymphotropic retrovirus STLV-1].

Arkh Patol 1997 Jan-Feb;59(1):19-25

Max von Pettenkofer Institute, Munchen, Germany.

8 cytological types were detected among 58 cases of T-NHL of Papio hamadryas according to human updated Kiel classification (1988). 5 of them were of low grade (lymphocytic, prolymphocytic, T-zone, angioimmunoblastic, small cell pleomorphic) and 3-of high grade (medium and large cell pleomorphic, immunoblastic, large cell anaplastic CD30/Ki-1+). There are differences in a tumor structure and generalization in baboon and human lymphomas in spite of significant similarities. Read More

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May 1997
4 Reads

Primary effusion lymphoma in women: report of two cases of Kaposi's sarcoma herpes virus-associated effusion-based lymphoma in human immunodeficiency virus-negative women.

Blood 1996 Oct;88(8):3124-8

Department of Pathology, Cedars Sinai Medical Center, School of Medicine 90048, USA.

Recent molecular evidence suggests an association with a new herpes virus, Kaposi's sarcoma-associated herpes virus (KSHV/HHV-8), and primary effusion lymphomas (PEL). PELs have a characteristic morphology, phenotype, and clinical presentation with malignant effusions in the absence of a contiguous solid tumor mass. Most cases of PEL have occurred in human immunodeficiency virus (HIV)-positive male patients who are coinfected with Epstein-Barr virus (EBV). Read More

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October 1996
4 Reads

[Primary cerebral non-Hodgkin's lymphomas and primary malignant brain tumors in a well-defined geographical area. Population-based data from the registry of non-Hodgkin's lymphoma in western Denmark, LYFO and the cancer registry, Kraeftens Bekaempelse].

Ugeskr Laeger 1996 Jul;158(31):4406-12

Aalborg Sygehus Syd, medicinsk-haematologisk afdeling og onkologisk afdeling.

In a Danish population-based non-Hodgkin's lymphoma (NHL) registry (LYFO) representing a population of 2.7 million all new cases of NHL were registered from 1st January 1983 to 31st May 1994. Incidence data of primary malignant tumours of the brain and central nervous system in western Denmark for the period 1971-1990 have been obtained from the Danish Cancer Registry. Read More

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July 1996
4 Reads

Histologic classification and immunophenotype of lymphosarcomas in cats with naturally and experimentally acquired feline immunodeficiency virus infections.

Vet Pathol 1996 May;33(3):264-72

Department of Veterinary Pathology, University of Glasgow, Bearsden, UK.

Lymphosarcoma (malignant lymphoma) is the commonest hematopoietic tumor in the cat. Many cases are associated with feline leukemia virus (FeLV) infection, but epidemiologic and experimental data suggest that feline immunodeficiency virus (FIV) may also have a role in lymphomagenesis. In this paper, we describe the clinical presentation, histologic classification, and immunophenotype of lymphosarcoma in eight domestic cats with natural or experimental FIV infections. Read More

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http://dx.doi.org/10.1177/030098589603300302DOI Listing
May 1996
5 Reads

Primary body cavity-based AIDS-related lymphomas.

Am J Clin Pathol 1996 Feb;105(2):221-9

Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072, USA.

Five patients with advanced AIDS developed a unique type of high grade primary body cavity-based non-Hodgkin's lymphoma (NHL). The lymphomas were exclusively in serous effusions with no detectable mass disease in the body cavities and no lymphadenopathy or organomegaly. All of the lymphomas exhibited virtually identical morphology, which could not be precisely classified, but appeared to bridge features of large cell immunoblastic and anaplastic large cell lymphomas. Read More

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February 1996
3 Reads

Expression of bcl-2 oncogene product in primary non-Hodgkin's malignant lymphoma of the oral cavity.

Pathol Res Pract 1996 Jan;192(1):44-53

Department of Oral Pathology, Nagasaki University School of Dentistry, Japan.

The B-cell leukemia/lymphoma-2 (bcl-2) proto-oncogene is peculiar, as its product appears to provide survival advantage to B cells by blocking apoptosis. Expression of bcl-2 protein was analyzed in 54 cases of primary non-Hodgkin's malignant lymphomas of the oral cavity by immunohistologic staining of paraffin-embedded tissue. The immunophenotype of each tumor was established with the use of a panel of monoclonal and polyclonal antibodies to lymphoid cell differentiation antigens. Read More

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http://dx.doi.org/10.1016/S0344-0338(96)80129-4DOI Listing
January 1996
3 Reads

Ki-1 (CD30) anaplastic large-cell lymphoma in children.

Ann Oncol 1995 Nov;6(9):915-20

Division of Pediatrics, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

Background: Ki-1 (CD30) ALCL is a rare and distinct type of high-grade NHL. A relevant feature is young age at presentation. Most reported pediatric series are retrospective analyses of heterogeneously-treated cases. Read More

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November 1995
4 Reads

Clinicopathological features, survival and prognostic factors of primary central nervous system lymphomas: trends in incidence of primary central nervous system lymphomas and primary malignant brain tumors in a well-defined geographical area. Population-based data from the Danish Lymphoma Registry, LYFO, and the Danish Cancer Registry.

Leuk Lymphoma 1995 Oct;19(3-4):223-33

Department of Haematology, Aalborg Hospital, Denmark.

It has been claimed that Primary Central Nervous System Lymphomas (PCNSL), a rare neoplasm accounting for only a small fraction of malignant brain tumors and extranodal non-Hodgkin lymphomas (NHL), occur with increasing frequency in immunologically normal as well as in immunocompromised individuals. In an attempt to characterize the clinicopathological features, outcome and prognostic factors of PCNSL we here report our experience in a large unselected series of patients from a well-defined region. In addition, we present data on trends in incidence of PCNSL and primary malignant brain tumors in a well-defined geographical area. Read More

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http://dx.doi.org/10.3109/10428199509107892DOI Listing
October 1995
5 Reads

Coherent view of non-Hodgkin's lymphoma.

Authors:
A C Aisenberg

J Clin Oncol 1995 Oct;13(10):2656-75

Hematology/Oncology Unit, Massachusetts General Hospital, Boston 02114, USA.

Purpose: Even though non-Hodgkin's lymphoma is already sixth in incidence and mortality among malignant neoplasms (and the incidence was increasing at a rate of 3% to 4% per year before the advent of AIDS epidemic-associated lymphomas), most physicians and many oncologists find the disorder arcane. The problem lies in the complexity of human lymphoma, which encompasses more than a dozen neoplasms of the lymphoid system. The goal of this review is to provide user-friendly access to the condition. Read More

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http://dx.doi.org/10.1200/JCO.1995.13.10.2656DOI Listing
October 1995
7 Reads

Primary cutaneous angiotropic large-cell lymphoma in a patient with acquired immunodeficiency syndrome.

Authors:
C H Dunphy

Arch Pathol Lab Med 1995 Aug;119(8):757-9

Department of Pathology, St Louis University Health Sciences Center, MO, USA.

Patients with acquired immunodeficiency syndrome are at increased risk of developing malignant lymphoma, particularly of the large noncleaved, immunoblastic, and small noncleaved cell types. Angiotropic large-cell lymphoma, a relatively rare high-grade lymphoma, has not previously been described in the setting of acquired immunodeficiency syndrome. Because angiotropic large-cell lymphoma most commonly involves the skin and central nervous system, and because of its relative rarity, its presentation in the skin of a patient with acquired immunodeficiency syndrome may pose a diagnostic dilemma. Read More

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August 1995
4 Reads

[Malignant lymphoma with medium-sized macronucleolated cells in the dog: involvement of an original cell from the marginal zone of the reactive lymph node].

Bull Acad Natl Med 1995 Jan;179(1):51-65

Ecole Vétérinaire de Lyon.

Among the non-Hodgkin's malignant lymphomas of the dog, which are largely dominated by the centroblastic heterogeneous type, there is an original form of malignant lymphoma which is homogeneous and diffuse, with macronucleolated medium-sized cells. These cells seem to be morphologically very similar to those which constitute the majority population in the marginal zone of the secondary follicle of the lymph node in the dog, and which appear in the course of certain conditions: systemic lupus erythematosus, leishmaniasis, satellite lymph nodes in benign or malignant tumors. The aim of this study was twofold: on the one hand to establish, in the canine species, the identity of the lymphomatous cells and the reactive cells that make up the marginal zone, i. Read More

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January 1995
6 Reads

Epstein-Barr virus-associated primary malignant lymphomas of the pleural cavity occurring in longstanding pleural chronic inflammation.

Hum Pathol 1994 Dec;25(12):1314-8

Service Central d'Anatomie et de Cytologie Pathologiques, Hôtel-Dieu, Paris.

Primary pleural non-Hodgkin's lymphomas (NHLs) have been described mostly in Japan and occasionally in western countries. We report three cases occurring in nonimmunocompromised patients demonstrating close similarities to the Japanese cases. These lymphomas occurred more than 20 years after thoracoplasty for the treatment of pleural or pulmonary tuberculosis. Read More

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December 1994
4 Reads

Differential expression of two ICAM-1 epitopes and LFA-1 chains in B-cell non-Hodgkin's lymphomas.

Eur J Haematol 1994 Aug;53(2):85-92

Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Italy.

B-cell non-Hodgkin's lymphomas (B-NHL) and B-cell areas of reactive lymphadenopathies were investigated immunohistochemically for expression of two distinct ICAM-1 epitopes, Me14/D12 and P3-58, and the LFA-1 alpha and beta chains. Partial or total loss of expression of one or both epitope(s) and/or chain(s) was evident in all B-NHL in function of increasing Working Formulation (WF) malignancy grade, with most defects in the high-grade tumors, namely the lowest detectability of the ICAM-1 Me14/D12 and LFA-1 alpha chain, the lowest co-expression of ICAM-1 epitopes and LFA-1 chains, and the most frequent simultaneous loss. The ICAM-1 and LFA-1 profiles overlapped within the low- and intermediate-grades, whereas striking differences between the high-grade subtypes were detected. Read More

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August 1994
3 Reads

[The larynx in lymphoproliferative and myeloproliferative diseases. I: An overview with special reference to primary laryngeal malignant lymphomas and plasmacytomas].

Authors:
H P Horny

HNO 1994 Jun;42(6):334-9

Abteilung für Spezielle Histopathologie und Zytopathologie, Universität Tübingen.

Lymphoreticular neoplasms of the larynx are rare and comprise a heterogeneous group of tumors. A systematic survey of the literature and autoptic evaluation of the larynx in a relatively small number of patients with systemic lymphoreticular malignancies yielded the following findings: Primary tumors of the larynx must be clearly distinguished from laryngeal involvement by systemic or leukemic infiltrations. By far the most common primary hemopoietic tumors of the larynx are extramedullary plasmacytoma (about 90 cases published) and non-Hodgkin's lymphoma (NHL; about 65 cases published). Read More

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June 1994
5 Reads

[Initial clinicopathological manifestations of malignant lymphoproliferative processes in patients with human immunodeficiency virus seropositivity. Study of 40 cases].

An Med Interna 1994 May;11(5):217-23

Sección de Oncología Médica, Unidad de Enfermedades Infecciosas, Hospital General Vall d'Hebron, Barcelona.

We analyzed the series of 40 malignant lymphoproliferative diseases (MLD) in HIV positive patients, diagnosed between 1986 and 1993 in a University Hospital in Spain. Median age was 32 years. 52% of the patients belonged to the intravenous drug users risk group, and 30% were homosexual. Read More

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May 1994
5 Reads

[Peripheral T cell lymphoma (immunoblastic type, HTLV-1 negative) associated with aganglionosis of the intestine].

Rinsho Ketsueki 1994 May;35(5):495-500

Department of Medicine, Shimizu Kousei Hospital.

A 56-year-old female was hospitalized in 1992, because of fever and lymphadenopathy. She had ileus due to aganglionosis of the intestine diagnosed in 1990. Blood tests disclosed anemia and thrombocytopenia. Read More

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May 1994
5 Reads

[Malignant lymphoma and colon carcinoma 3 years after heart transplantation and immunosuppression].

Pathologe 1994 Apr;15(2):129-33

Institut für Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil Bochum, Ruhr-Universität Bochum.

Three years after heart transplantation and immunosuppressive therapy, a 66-year-old man suffered from dyspnea and showed symptoms mainly due to right heart failure. Malignant tumor cells were discovered within extensive pleural effusion. Computed tomography revealed two lesions of the liver suspicious of metastases, and recurrent blood in the stools was evident. Read More

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April 1994
4 Reads

Malignant lymphoma of the testis, epididymis, and spermatic cord. A clinicopathologic study of 69 cases with immunophenotypic analysis.

Am J Surg Pathol 1994 Apr;18(4):376-90

James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston 02114.

We studied 69 cases of malignant lymphoma of the testis, epididymis, and spermatic cord, including 64 cases in which the tumor involved these sites at presentation and five cases in which lymphoma relapsed in the testis. The patients without prior lymphoma were 16 to 91 (mean, 56) years old. Fifty-two patients had diffuse large-cell lymphomas [seven large cleaved cell (two with follicular areas), 27 large noncleaved, two multilobated, six not otherwise specified (NOS), 10 immunoblastic]; six, small noncleaved cell; two, diffuse mixed small and large cell; one, diffuse small cleaved; one, follicular mixed small cleaved and large cell; and two, high grade, unclassified in the Working Formulation. Read More

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April 1994
5 Reads

Incidence, clinicopathological features and outcome of primary central nervous system lymphomas. Population-based data from a Danish lymphoma registry. Danish Lymphoma Study Group, LYFO.

Ann Oncol 1994 Apr;5(4):349-54

Department of Haematology, Aalborg Hospital, Denmark.

Background: Primary Central Nervous System lymphomas (PCNSL), a rare neoplasm accounting for only a small fraction of malignant brain tumors and extranodal non-Hodgkin's lymphomas (NHL), seems to occur with increasing frequency in immunologically-normal as well as immunocompromised individuals. In an attempt to characterize the clinicopathological features, incidence rate and outcome of PCNSL, we here report our experience in a large unselected group of patients from a well-defined region.

Patients And Methods: In a Danish population-based NHL registry (LYFO) representing a population of 2. Read More

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April 1994
6 Reads

Unusual clinical aspects of oral non-Hodgkin lymphomas in patients with HIV infection.

Eur J Cancer B Oral Oncol 1994 Jan;30B(1):61-4

Institute of Odontology and Stomatology, Florence, Italy.

Patients with HIV infection are at greater risk of developing malignancies. We report two HIV-seropositive patients with primary oral manifestation of a B-cell non-Hodgkin lymphoma (NHL). Localisations of tumours were the palate, with an unusual bifocal origin, and the tongue which is rarely the primary site of NHL. Read More

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January 1994
3 Reads

[AIDS-related malignancy].

Authors:
K Sakurada

Hokkaido Igaku Zasshi 1993 Sep;68(5):612-4

Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

Although Kaposi's sarcoma (KS) has been considered a rare disease, the disease is well known at present since the onset of AIDS in 1981. The characteristics of AIDS-associated KS are a multifocal, widespread distribution that may involve lymph node, gastrointestinal tract, and visceral organs. KS may be the first sign of HIV-infection, but it can also arise in some patients who lack evidences of immune impairment. Read More

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September 1993
4 Reads

Biologic aspects of AIDS-associated non-Hodgkin's lymphoma.

Authors:
D M Knowles

Curr Opin Oncol 1993 Sep;5(5):845-51

Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032.

Acquired immunodeficiency syndrome-associated non-Hodgkin's lymphomas represent a significant and formidable clinical problem. They also represent an important biologic model for investigating the development and progression of high-grade malignant lymphomas and for studying lymphomas that develop in the setting of immune deficiency. A vast majority of non-Hodgkin's lymphomas exhibit clonal immunoglobulin gene rearrangements and, hence, are B-cell neoplasms. Read More

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September 1993
4 Reads

Brain lymphomas of immunocompetent and immunocompromised patients: study of the association with Epstein-Barr virus.

Mod Pathol 1993 Jul;6(4):427-32

Department of Pathology, City of Hope National Medical Center, Duarte, CA.

The Epstein-Barr virus (EBV) has been described in association with lymphomas of the central nervous system. To test if the association between EBV and central nervous system lymphomas was limited to patients with immunosuppression or whether the association also held for patients who were immunocompetent and to determine the true prevalence of any association, we studied 37 formalin-fixed, paraffin-embedded cases of central nervous system lymphomas occurring in immunocompromised and immunocompetent patients. EBV DNA-RNA in situ hybridization was performed using a 30-base biotinylated antisense oligonucleotide complementary to the EBER1 gene of EBV. Read More

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July 1993
5 Reads

Breast lymphoma. A B-cell spectrum including the low grade B-cell lymphoma of mucosa associated lymphoid tissue.

Am J Surg Pathol 1993 Jun;17(6):574-87

James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston 02114.

We studied the morphologic, immunologic, and clinical features of 31 cases of malignant lymphoma involving the breast. Primary breast lymphoma occurred in nine women with a median age of 69 years (range, 51-87 years); median follow-up was 31 months (range, 9-67 months). Eight cases were low grade, one was high grade, and all expressed B-lineage antigens. Read More

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June 1993
6 Reads

Gene rearrangement of bcl-1 and bcl-2 is confined to distinct subgroups of high-grade malignant B-cell lymphomas.

J Pathol 1993 Mar;169(3):303-7

Institute of Pathology, University of Würzburg, Germany.

The occurrence of bcl-1 and bcl-2 gene rearrangements was investigated in 37 cases of high-grade B-cell lymphomas. Bcl-2 rearrangement was detectable only in single cases of primary centroblastic lymphoma with a follicular growth pattern, whereas secondary centroblastic lymphomas evolving from a centroblastic-centrocytic lymphoma were positive in up to 60 per cent of the cases analysed. Bcl-1 rearrangement was found only in one case of immunoblastic B-cell lymphoma with a history of pre-existing lymphoplasmacytoid immunocytoma. Read More

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http://dx.doi.org/10.1002/path.1711690305DOI Listing
March 1993
2 Reads

Primary non-Hodgkin lymphomas of the CNS. Classification, tissue reaction and proliferative activity.

Zentralbl Pathol 1993 Mar;139(1):37-44

Institut of Neuropathology, University of Münster, Germany.

Primary cerebral lymphomas (PCL) are rare tumors, which, however, occur at increasing frequency. From 1980 to 1991, 44 PCL were histologically diagnosed from immunocompetent patients in our department. According to the updated Kiel Classification, 13. Read More

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March 1993
4 Reads

Morphological characteristics of malignant T-cell lymphomas in baboons.

Virchows Arch A Pathol Anat Histopathol 1993 ;422(2):109-20

Institute of Experimental Pathology and Therapy, Sukhumi, Abkhazia, Georgia.

Fifteen cases of generalized peripheral T-cell non-Hodgkin's lymphoma in baboons were phenotyped immunologically and morphologically. Using the updated Kiel classification the cases included low-grade and high-grade lymphomas and low-grade lymphomas that had transformed into high-grade lymphomas. In the low-grade group there were seven cases of lymphocytic type, partly corresponding to chronic lymphocytic leukaemia of T type and to T-zone lymphoma in man. Read More

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May 1993
4 Reads