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Clin Lymphoma Myeloma Leuk 2019 Apr 1. Epub 2019 Apr 1.

Division of Hematology, Mayo Clinic, Rochester, MN. Electronic address:

Background: Limited knowledge exists on the incidence, treatment patterns, and long-term outcomes of Langerhans cell sarcoma (LCS) in the United States.

Patients And Methods: We performed a retrospective study of LCS patients diagnosed between 2001 and 2014 using the Surveillance, Epidemiology, and End Results (SEER) and National Cancer Data Base (NCDB) databases. Incidence was calculated from SEER, and treatment patterns and outcomes were calculated from NCDB. Read More

Radiother Oncol 2019 May 5;134:89-95. Epub 2019 Feb 5.

Department of Radiation Oncology, St. Jude Children's Hospital, Memphis, United States.

Background And Purpose: The use of radiotherapy (RT) for pediatric patients with Hodgkin lymphoma (HL) experiencing disease progression or recurrence (15%) is controversial. We report treatment patterns and outcomes for pediatric patients with refractory/recurrent HL (rrHL) treated with curative-intent RT.

Materials And Methods: Forty-six patients with rrHL treated with salvage RT at our institution were identified. Read More

Am J Hematol 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.

Int J STD AIDS 2019 Apr 4;30(5):522-525. Epub 2019 Feb 4.

Department of Dermatology & Venereology, Govt. Medical College, Thrissur, Kerala.

Bowenoid papulosis (BP) is a premalignant condition usually caused by oncogenic types of human papillomavirus (HPV) presenting clinically as warty genital papules. Adult T-cell leukaemia-lymphoma (ATLL) is a peripheral T-cell leukaemia-lymphoma caused by the retrovirus, human T-cell lymphotropic virus 1 (HTLV-1). We report a case of BP initially mistaken as genital warts; on detailed evaluation the patient had features of chronic immunosuppression. Read More

Eur J Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Dermatologie, Institut Universitaire du Cancer de Toulouse, Université Paul Sabatier, Hôpital Larrey et Oncopole, Toulouse.

Background: There is a certain degree of controversy as to whether bone marrow biopsy is required during the staging procedures for primary cutaneous follicle centre B-cell lymphoma (PCFCCL).

Objectives: Firstly, to determine extra-cutaneous involvement at initial diagnosis, in particular, based on bone marrow biopsy, and secondly, evaluate the phenotypic features associated with extra-cutaneous involvement during follow-up (in particular, the predictive value of BCL2 and CD10 coexpression and identification of t[14;18] in skin lesions, as well as bone marrow biopsy involvement at initial staging) in a cohort of patients with PCFCCL.

Materials & Methods: A bicentric retrospective study was established to investigate 75 cases of PCFCCL, for which 44 bone marrow biopsies were performed. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):439-444

Clinical College of 307 Hospital, PLA, Anhui Medical University; Hefei 230032, Anhui Province, China,Department of Lymphoma, General Hospital of PLA Fifth Medical Center, Beijing 100071,

Objective: To explore whether tumor suppressor gene Foxo1 and PTEN play a critical role in the tumorigenesis of mouse natural killer-cell lymphoma.

Methods: NKp46-iCre mice were crossed with mice carrying floxed Foxo1 alleles (Foxo1) as well as floxed PTEN alleles (PTEN) to generate mice in which Foxo1 and PTEN in NK cells were knock-out, referred as Foxo1PTEN. The growth and development of the mice and tumor formation were observed. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):421-425

Department of Hematology, Peking Union Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China,E-mail:

Objective: To determine the significance of morphology of bone marrow smear for diagnosis of bone marrow involvement in patients with diffuse large B-cell lymphoma (DLBCL), and to study the morphological characteristics of DLBCL cells involved in bone marrow.

Methods: Four hundred and twenty cases of DLBCL diagnosed at Peking Union Hospital from 2006 to 2016 were analyzed and identified.

Results: Blinded analysis of bone marrow smear and bone marrow biopsy data showed involvement in 42 cases on smears (S), in 47cases by biopsy (B) and the in 49 cases by (S+B). Read More

Leuk Lymphoma 2019 Apr 18:1-11. Epub 2019 Apr 18.

a Department of Leukemia , University of Texas MD Anderson Cancer Center , Houston , TX , USA.

Acute myeloid leukemia (AML) is a heterogeneous disease and remains a therapeutic challenge. Cytogenetics is a well-established prognostic factor. Recent discovery of molecular mutations has gained momentum with some being potential therapeutic targets. Read More

Chin J Cancer Res 2019 Feb;31(1):152-161

Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma (DLBCL) patients in China according to the primary site.

Methods: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary site. Read More

Clin Lymphoma Myeloma Leuk 2019 Mar 8. Epub 2019 Mar 8.

Division of Hematology, Oncology and Stem Cell Transplant, Rush University Medical Center, Chicago, IL. Electronic address:

Clin Lymphoma Myeloma Leuk 2019 Mar 22. Epub 2019 Mar 22.

University of Michigan Rogel Cancer Center, Ann Arbor, MI.

The discovery of a mutation in the Janus Kinase 2 gene in 2005 spurred significant progress in the field of myeloproliferative neoplasms. A comprehensive description of genomic factors at play in the malignant clone in myeloproliferative neoplasms, particularly myelofibrosis (MF), have recently led to more precise, personalized prognostic tools. Despite this, understanding of the disease pathogenesis remains relatively limited. Read More

Eur J Haematol 2019 Apr 15. Epub 2019 Apr 15.

Service de médecine interne, Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Est, Créteil, France.

Objective: Angioimmunoblastic T-cell lymphoma (AITL) are frequently associated with autoimmune cytopenia (AIC). Whether such patients have a particular phenotype and require particular management is unclear.

Method: AITL patients from the multicentric database of the Lymphoma Study Association presenting with AIC during disease course were included and matched to AITL patients without AIC (1/5 ratio). Read More

Medicine (Baltimore) 2019 Apr;98(15):e15204

Department of Hematology, The First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan Province, China.

Rationale: Second diffuse large B-cell lymphoma (DLBCL) after treatment of acute lymphoblastic leukemia (ALL) is uncommon. To our knowledge, primary middle ear DLBCL which presents CD20-negative and coexpression of MYC and BCL-2 has not been reported yet.

Patient Concerns: A 20-year-old Chinese man complained fever and weakness for 2 months. Read More

Appl Biochem Biotechnol 2019 Apr 12. Epub 2019 Apr 12.

Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Acute kidney injury (AKI) is a rapid loss of renal function. It has high mortality rates. Still, renal replacement therapy is considered the best solution for recovering AKI. Read More

Cell Death Dis 2019 Apr 11;10(4):320. Epub 2019 Apr 11.

Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, 88100, Italy.

Increasing evidence supports the involvement of IBTK in cell survival and tumor growth. Previously, we have shown that IBTK RNA interference affects the wide genome expression and RNA splicing in cell-type specific manner. Further, the expression of IBTK gene progressively increases from indolent to aggressive stage of chronic lymphocytic leukemia and decreases in disease remission after therapy. Read More

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):199-205

Department of Pathology, Regional Cancer Centre, Thiruvananthpuram, Kerala, India.

Small round cell lesions of the bone encompass a heterogeneous group of tumors and tumor-like lesions, including Ewing sarcoma, small cell osteosarcoma, mesenchymal chondrosarcoma, neuroblastoma, non-Hodgkin's lymphoma (NHL), "Ewing-like" undifferentiated round cell sarcomas, metastasizing small cell carcinoma, along with plasma cell dyscrasia and Langerhan's cell histiocytosis. At the same time, there are tumor mimics, for example, chronic osteomyelitis, which has overlapping radiologic features with Ewing sarcoma and a primary intraosseous NHL. An exact diagnosis necessitates integration of clinical, radiologic, pathologic, and ancillary test results, including immunohistochemical and molecular results. Read More

JBRA Assist Reprod 2019 Apr 10. Epub 2019 Apr 10.

Fertility Center of Ribeirão Preto (CEFERP) - Ribeirão Preto - São Paulo - Brasil.

Advances in the early diagnosis and treatment of cancer have reduced mortality rates and improved patient survival. For this reason, professionals from different areas have strived to implement actions to increase patient quality-of-life during and after cancer treatment. Among these measures, integral attention in reproductive health is one of the main points for the inclusion, safety, and autonomy of female patients. Read More

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):17-22

Department of Oral and Maxillofacial Surgery, GSL Dental College, Rajahmundry, Andhra Pradesh, India.

Lymphomas of the oral cavity are rare and represent only 3%-5% of all lymphomas. Diffuse large B-cell lymphomas (DLBCLs) are a heterogeneous group of tumor and the most common type of all non-Hodgkin's lymphomas (NHLs). They mostly arise from soft tissue as asymptomatic swelling and involvement of jaw bones is infrequent. Read More

Clin Nephrol 2019 Apr 9. Epub 2019 Apr 9.

The kidney is among the various anatomical sites involved in mucosa-associated lymphoid tissue (MALT) lymphoma. A variety of renal pathological types, including membranous glomerulopathy, membranoproliferative glomerulonephritis, crescentic IgA nephropathy, minimal change disease, and cryoglobulinemic glomerulopathy, have been reported in MALT lymphoma patients. However, cast nephropathy is extremely rare in MALT lymphoma. Read More

AAPS J 2019 Apr 8;21(3):50. Epub 2019 Apr 8.

Department of Medicine, Mayo Clinic Division of Hematology, Rochester, Minnesota, 55905, USA.

The advent of the genome editing era brings forth the promise of adoptive cell transfer using engineered chimeric antigen receptor (CAR) T cells for targeted cancer therapy. CAR T cell immunotherapy is probably one of the most encouraging developments for the treatment of hematological malignancies. In 2017, two CAR T cell therapies were approved by the US Food and Drug Administration: one for the treatment of pediatric acute lymphoblastic leukemia (ALL) and the other for adult patients with advanced lymphomas. Read More

Proc (Bayl Univ Med Cent) 2019 Jan 7;32(1):129-130. Epub 2019 Jan 7.

Department of Pathology, Baylor University Medical CenterDallasTexas.

Hepatosplenic T-cell lymphoma (HSTCL) is a rare T-cell lymphoma, primarily characterized by extranodal distribution of the malignant cells with intrasinusoidal infiltration of the liver, spleen, and bone marrow, which is associated with a poor outcome. We describe a unique case of a 47-year-old woman with a clinical presentation of headaches, fevers, elevated liver function tests, and hepatosplenomegaly. A liver biopsy revealed a striking hepatic intrasinusoidal infiltrate of lymphocytes. Read More

Blood 2019 Apr 5. Epub 2019 Apr 5.

City of Hope Medical Center, United States.

Autologous stem cell transplantation (ASCT) remains the standard of care for patients with relapsed/refractory classical Hodgkin lymphoma (RR cHL) who respond to salvage chemotherapy. However, relapse after ASCT remains a frequent cause of treatment failure, with poor subsequent prognosis. Since cHL is uniquely vulnerable to PD-1 blockade, PD-1 blockade given as consolidation after ASCT could improve ASCT outcomes. Read More

PLoS One 2019 5;14(4):e0215021. Epub 2019 Apr 5.

Division of Hematology-Oncology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, United States of America.

Idiopathic acquired aplastic anemia (AA) is a rare lymphocyte-mediated bone marrow aplasia. No specific mechanisms or triggers of AA have been identified. We recently observed several patients who developed AA after Hodgkin lymphoma (HL). Read More

Clin Lymphoma Myeloma Leuk 2019 Mar 11. Epub 2019 Mar 11.

Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah-Tikva, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Introduction: There is paucity of data regarding the cardiotoxic effects of anthracycline treatment in the context of acute myeloid leukemia (AML) patients who undergo allogeneic hematopoietic stem cell transplantation (HSCT). Even a transient decrease in cardiac function might affect transplantation outcome.

Patients And Methods: We reviewed the clinical records and echocardiography examinations of 78 patients with AML who received induction therapy and underwent HSCT. Read More

Pathol Res Pract 2019 Mar 27. Epub 2019 Mar 27.

Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan.

A 70-year-old woman developed severe buttock pain that progressed to a walking disturbance. Radiographs and computed tomography scans revealed an osteolytic lesion with osteosclerosis extending from the body to the arch of the fifth lumbar vertebra. Magnetic resonance imaging showed multinodular masses in the fifth lumbar vertebral body extending into the spinous processes and right transverse process. Read More

Leuk Lymphoma 2019 Apr 5:1-7. Epub 2019 Apr 5.

d Hematology Division, 2nd Department of Internal Medicine , "ATTIKO" General University Hospital, National and Kapodistrian University of Athens , Athens , Greece.

The aim of the present study was to identify biomarkers predictive of the outcome of patients with high-risk myelodysplastic syndrome and oligoblastic acute myeloid leukemia (AML) treated with 5-azacytidine (AZA). We prospectively examined the association between NK-cytotoxic activity, myeloid-derived suppressor cells (MDSCs), and T-regulatory cells (Tregs) on the overall survival (OS) of patients. Patients with NK-cytotoxicity above a critical threshold had a longer duration of response and survived longer than patients with severe impairment of NK-cytotoxicity. Read More

Leuk Lymphoma 2019 Apr 5:1-9. Epub 2019 Apr 5.

h Department of Leukemia , University of Texas M.D. Anderson Cancer Center , Houston , TX , USA.

Outcomes for adults with relapsed/refractory acute lymphoblastic leukemia (ALL) are poor with chemotherapy, particularly in later salvage. The TOWER study examined survival, remission, bridge to allogeneic hematopoietic stem cell transplantation (HSCT), and safety with blinatumomab versus chemotherapy. This report examined outcomes separately for study treatment as first or later salvage. Read More

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange. Electronic address:

Epstein-Barr virus (EBV) is associated with many neoplastic hematologic conditions, but scattered EBV positive cells can be detected in lymph nodes of healthy individuals and they usually represent latently infected lymphocytes. The incidence of EBV detection in normal bone marrow samples has not been studied and is largely unknown. The lack of knowledge regarding the true incidence of encountering bystander latent EBV-positive cells in the bone marrow may potentially lead to a diagnostic dilemma when assessing a staging bone marrow for a patient with an EBV-positive B or T/NK-cell lymphoma. Read More

Case Rep Orthop 2019 3;2019:3174768. Epub 2019 Mar 3.

Department of Haematology, Altnagelvin Area Hospital, Glenshane Road, Londonderry, Co. Londonderry, Ireland.

Introduction: Primary bone lymphoma (PBL) is a rare bone malignancy which may present with atraumatic pain, swelling, or pathological fracture. Whilst the femur is the most commonly affected site, any bone may be involved. PBL should be distinguished from other bone lesions to determine clinical management. Read More

Acta Haematol 2019 Apr 3;141(4):216-221. Epub 2019 Apr 3.

Department of Hematology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel,

Background: The treatment of relapsed/refractory (R/R) peripheral T cell lymphoma (PTCL) is limited to a few agents. Romidepsin, a histone deacetylase inhibitor, was approved for PTCL treatment as a single agent in the R/R setting, yet with partial efficacy. Several attempts to combine romidepsin with other chemotherapy regimens have been reported, however, with significant toxicity. Read More

Leuk Lymphoma 2019 Apr 3:1-8. Epub 2019 Apr 3.

a Department of Hematology and Bone Marrow Transplantation , Rambam Health Care Campus , Haifa , Israel.

Autologous stem cell transplantation (ASCT), intensifying anti-leukemic effects without significant treatment-related mortality (TRM), is particularly appealing in AML with favorable genetic/molecular profile. This study retrospectively evaluated the outcomes of post-remission treatment in consecutive favorable-risk AML patients. Sixty-six patients were included: 32 had mutated NPM1/wild-type FLT-ITD, 16 had t(8:21) and 18 - inv(16). Read More

Leuk Lymphoma 2019 Apr 3:1-8. Epub 2019 Apr 3.

a Department of Clinical Hematology, ICO-Hospital Germans Trias i Pujol. Institut de Recerca Josep Carreras , Universitat Autònoma de Barcelona , Badalona , Spain.

Short responses to immunochemotherapy predict for an inferior OS in follicular lymphoma. We set out to determine whether this is also the case in marginal zone lymphoma. A group of 139 marginal zone lymphoma (MZL) patients treated with front-line immuno- or immunochemotherapy (I/ICT) were categorized into I/ICT-refractory (non-response or relapse/progression within six months of treatment response assessment) or I/ICT-sensitive. Read More

Case Rep Pathol 2019 3;2019:4915086. Epub 2019 Mar 3.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in Western countries with an incidence of 3-5 cases per 100,000 persons. Most patients follow an indolent clinical course with eventual progression and need for therapy. In contrast, T-prolymphocytic leukemia (T-PLL) is a rare type of T-cell leukemia with most patients having an aggressive clinical course and a dismal prognosis. Read More

Oncologist 2019 Apr 2. Epub 2019 Apr 2.

Institute of Hematology, University of Bologna, Bologna, Italy

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma subtype, and approximately 50% of the patients are >60 years of age. Patients with relapsed/refractory (rr) disease have a poor prognosis with currently available treatments. Lenalidomide is available in Italy for patients with rrDLBCL based on a local disposition of the Italian Drug Agency. Read More

Blood Adv 2019 Apr;3(7):1033-1038

Department of Medicine III, University Hospital, and.

The Follicular Lymphoma (FL) International Prognostic Index (FLIPI) and FLIPI-2 are well-described clinical risk models. Age >60 years at diagnosis is a risk factor in both scores. Recently, we showed that older age is not associated with higher risk of disease progression or inferior treatment efficacy. Read More

J Oncol Pharm Pract 2019 Apr 2:1078155219841110. Epub 2019 Apr 2.

University of Health Sciences, Ankara Dr. Abdurrahman Yurtaslan Oncology Research and Training Hospital, Hematology Clinic and Bone Marrow Transplantation Unit, Ankara, Turkey.

Introduction: The aim of this study was to investigate the influence of high-dose cytosine arabinoside (HDAC)-containing treatments followed by autologous hematopoietic stem cell transplantation on the survival of patients with mantle cell lymphoma.

Material And Methods: The data of 27 MCL patients who were followed-up between January 2009 and December 2015 were analyzed retrospectively.

Results: The median age of the patients was 63 (range, 45-82) with 22 (81. Read More

Case Rep Dent 2019 27;2019:6701783. Epub 2019 Feb 27.

Department of Stomatology, School of Dentistry, University of São Paulo, 2227 Lineu Prestes Avenue, 05508-000 São Paulo, SP, Brazil.

Extranodal natural killer/T-cell lymphoma (ENKL) is an aggressive and infrequent malignant neoplasm. Early sinonasal ENKL clinical symptomatology is often not specific which can mimic several clinical odontogenic processes such as dentoalveolar abscesses. A 41-year-old female was referred to our institution due to facial pain with skin rash, fever, and intraoral swelling in the left side of the maxillary region. Read More

J Exp Med 2019 Apr 1. Epub 2019 Apr 1.

Dynamics of Immune Responses Unit, Equipe Labellisée Ligue Contre le Cancer, Institut Pasteur, INSERM U1223, Paris, France

CAR T cells represent a potentially curative strategy for B cell malignancies. However, the outcome and dynamics of CAR T cell interactions in distinct anatomical sites are poorly understood. Using intravital imaging, we tracked interactions established by anti-CD19 CAR T cells in B cell lymphoma-bearing mice. Read More

Mol Clin Oncol 2019 Apr 27;10(4):441-445. Epub 2019 Feb 27.

Department of Medical Oncology, Kobe City Medical Center General Hospital, Kobe City Hospital Organization, Kobe, Hyogo 650-0047, Japan.

Immune thrombocytopenic purpura (ITP) is characterized by antibody and immune platelet destruction, occasionally leading to life-threatening hemorrhage. ITP is a frequent complication of chronic lymphoid leukemia, but is rarely associated with diffuse large B-cell lymphoma (DLBCL). We herein describe a case of ITP associated with T-cell/histiocyte-rich B-cell lymphoma (T/HRBCL), which is a rare variant of DLBCL. Read More

Front Immunol 2019 15;10:457. Epub 2019 Mar 15.

Fox Chase Cancer Center, Philadelphia, PA, United States.

The Lin28bLet7 axis in fetal/neonatal development plays a role in promoting CD5 B1a cell generation as a B-1 B cell developmental outcome. Here we identify the Let7 target, Arid3a, as a crucial molecular effector of the B-1 cell developmental program. Arid3a expression is increased at pro-B cell stage and markedly increased at pre-B and immature B cell stages in the fetal/neonatal liver B-1 development relative to that in the Lin28bLet7 adult bone marrow (BM) B-2 cell development. Read More

Joint Bone Spine 2019 Mar 27. Epub 2019 Mar 27.

Université Côte d'Azur, faculté de médecine de Nice, 06200 Nice, France; Service de médecine interne, CHU de l'Archet, Nice, 06200 Nice, France. Electronic address:

Cancers (Basel) 2019 Mar 28;11(4). Epub 2019 Mar 28.

IGH, CNRS, University of Montpellier, 34000 Montpellier, France.

Background: Multiple myeloma (MM) is the second most common hematological cancer after lymphoma. It is characterized by the accumulation of clonal malignant plasma cells within the bone marrow. The development of drug resistance remains a major problem for effective treatment of MM. Read More

Am J Transplant 2019 Mar 27. Epub 2019 Mar 27.

Division of Hematology, Jichi Medical University, Shimotuke, Japan.

Patients who undergo kidney transplantation are at increased risk of cancer due to the long-term use of immunosuppressive treatment. Postrenal transplant cancers usually originate from recipient cells, but donor-related cancers have been rarely reported. We report the case of 49-year-old woman who developed multiple myeloma of donor origin 7 years after kidney transplantation. Read More

Am J Hematol 2019 Mar 27. Epub 2019 Mar 27.

Division Hematology, Oncology, and Bone Marrow Transplantation, University of Iowa, Iowa City, Iowa.

Indolent B-cell lymphomas other than follicular lymphoma account for up to 10% of all B-cell neoplasms. While they typically follow a slowly progressive course, some patients experience rapid progression and early mortality. Prognostic scoring systems have not been adopted, hindering the ability of clinicians or researchers to predict outcomes, or risk-stratify patients during clinical trials. Read More

Case Rep Hematol 2019 20;2019:3540487. Epub 2019 Feb 20.

Mayo Clinic, Jacksonville, FL, USA.

Cutaneous involvement by precursor T-cell lymphoblastic leukemia/lymphoma (T-ALL/LBL) is rare, and almost all cases are seen in association with bone marrow, blood, and/or lymph node involvement. Presentation with isolated skin involvement is very rare. Literature review revealed only one case report of primary cutaneous T-cell LBL. Read More

Leuk Lymphoma 2019 Mar 26:1-11. Epub 2019 Mar 26.

a Centre for Regenerative Medicine and Stem Cell Research, Aga Khan University , Karachi , Pakistan.

Multiple myeloma (MM) is a heterogeneous disease of the bone marrow (BM). Its association with Epstein-Barr virus (EBV) remains enigmatic. Aim of our study was to determine expression of latent membrane protein 1 (LMP1), aldehyde dehydrogenase 1 (ALDH1), CD117 and their association with 5-year survival in MM patients. Read More

Int J Biol Sci 2019 1;15(4):870-881. Epub 2019 Mar 1.

State Key Laboratory of Reproductive Medicine, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu, China.

The polycomb repressor B lymphoma Mo-MLV insertion region 1 (BMI1) is a core composition of polycomb repressive complex 1 (PRC1) and contributes to diverse fundamental cellular processes including cell senescence, apoptosis and proliferation. To investigate the role and mechanism of BMI1 in maintaining normal female reproductive function, we compared the differences in reproductive phenotypes between Bmi1-deficient and wild-type female mice. The Bmi1-deficient female mice were then supplemented with N-acetylcysteine in their drinking water to explore whether antioxidant supplementation could improve reproductive dysfunction caused by BMI1 deficiency. Read More

Prog Mol Biol Transl Sci 2019 6;162:199-212. Epub 2019 Mar 6.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Alpha-fetoprotein (AFP) is a glycoprotein and belongs to the gene family of serum albumins. The serum AFP levels were found to be elevated in the sera of liver cancer patients in 1964 and were subsequently developed and used as a liver cancer biomarker. However, elevated serum AFP levels have been observed in patients suffering from other cancer and noncancer diseases. Read More

Clin Lymphoma Myeloma Leuk 2019 Feb 22. Epub 2019 Feb 22.

Department of Radiation Oncology, Mount Sinai Hospital, New York, NY.

Background: Patients with multiple myeloma (MM) are living longer than ever before thanks to new therapies. As a consequence, radiation therapy (RT) is increasingly important in the management of bone lesions from MM. Current American Society for Radiation Oncology guidelines recommend greater usage of 8 Gy in 1 fraction for treatment of these lesions. Read More

Am J Med Sci 2019 Apr 21;357(4):302-310. Epub 2019 Jan 21.

Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China. Electronic address:

Background: A few studies have evaluated the expression of chemokine receptors CXCR4 and CCR7 in diffuse large B-cell lymphoma (DLBCL); however, the association between CXCR4 and CCR7 with bone marrow (BM) involvement and their synergistic effect on prognosis is still unclear. Our study investigated this aspect.

Methods: Specimens were obtained from 61 primary nodal DLBCL patients and 100 reactive proliferative lymphadenitis patients. Read More