75,297 results match your criteria Lymphoma B-Cell


Tisagenlecleucel in Diffuse Large B-Cell Lymphoma. Reply.

N Engl J Med 2019 Apr;380(16):1586

University of Pennsylvania, Philadelphia, PA

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http://dx.doi.org/10.1056/NEJMc1901464DOI Listing

Tisagenlecleucel in Diffuse Large B-Cell Lymphoma.

N Engl J Med 2019 Apr;380(16):1585-1586

Rocket Pharmaceuticals, New York, NY

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http://dx.doi.org/10.1056/NEJMc1901464DOI Listing

Tisagenlecleucel in Diffuse Large B-Cell Lymphoma.

N Engl J Med 2019 Apr;380(16):1585

McGill University, Montreal, QC, Canada

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http://dx.doi.org/10.1056/NEJMc1901464DOI Listing

PACAP Attenuates Optic Nerve Crush-Induced Retinal Ganglion Cell Apoptosis Via Activation of the CREB-Bcl-2 Pathway.

J Mol Neurosci 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 7 Jinsui Road, Guangzhou, 510623, China.

Retinal ganglion cell (RGC) apoptosis is considered an important pathological hallmark of glaucoma. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic peptide with potent neuroprotective properties. In our previous study, we found that the expression of PACAP and its high-affinity receptor PACAP receptor type 1 (PAC1R) increased markedly after optic nerve crush (ONC), and occurred mainly in the ganglion cell layer of the retina. Read More

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http://dx.doi.org/10.1007/s12031-019-01309-9DOI Listing

Bortezomib for the Treatment of Hematologic Malignancies: 15 Years Later.

Drugs R D 2019 Apr 16. Epub 2019 Apr 16.

Department of Hematology, Medical University of Lodz, Ul. Ciolkowskiego 2, 93-510, Lodz, Poland.

Bortezomib is a dipeptidyl boronic acid that selectively inhibits the ubiquitin proteasome pathway, which plays a role in the degradation of many intracellular proteins. It is the first-in-class selective and reversible inhibitor of the 26S proteasome, with antiproliferative and antitumor activity. It exerts its anti-neoplastic action mainly via the inhibition of the nuclear factor-κB pathway components associated with cell proliferation, apoptosis, and angiogenesis. Read More

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http://dx.doi.org/10.1007/s40268-019-0269-9DOI Listing

Two Pathways of p27 Degradation Are Required for Murine Lymphoma Driven by Myc and EBV Latent Membrane Protein 2A.

MBio 2019 Apr 16;10(2). Epub 2019 Apr 16.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A), expressed in EBV latency, contributes to Burkitt lymphoma (BL) development in a murine model by acting as a constitutively active B cell receptor (BCR) mimic. Mice expressing both LMP2A and transgenes (LMP2A/λ-) develop tumors significantly faster than mice only expressing (λ-). Previously, we demonstrated the cell cycle inhibitor p27 is present at significantly lower levels in LMP2A/λ- mice due to increased posttranslational degradation. Read More

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http://dx.doi.org/10.1128/mBio.00548-19DOI Listing

Significance of spermatic cord invasion in radical inguinal orchidectomy: Will a modified subinguinal orchidectomy suffice?

Urologia 2019 Apr 16:391560319840529. Epub 2019 Apr 16.

Department of Urology, University Hospital Limerick, Limerick, Ireland.

Introduction And Objectives: Radical inguinal orchidectomy with ligation and division of the spermatic cord at the deep inguinal ring is the treatment of choice for testicular mass suspicious of cancer. In the era of organ preserving and minimally invasive surgery, it may be possible to propose a less radical sub-inguinal orchidectomy that may avoid the morbidity associated with opening the inguinal canal. The effect of this approach on oncological margins is not known. Read More

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http://dx.doi.org/10.1177/0391560319840529DOI Listing

Designing optimal prognostic models for diffuse large B-cell lymphoma.

Leuk Lymphoma 2019 Apr 16:1-3. Epub 2019 Apr 16.

c Department of Hematology , Sir Charles Gairdner Hospital , Nedlands , Australia.

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http://dx.doi.org/10.1080/10428194.2019.1599117DOI Listing

X-Linked Lymphoproliferative Syndrome Presenting as Adult-Onset Multi-Infarct Dementia.

J Neuropathol Exp Neurol 2019 May;78(5):460-466

Department of Neurology, Mayo Clinic, Jacksonville, Florida.

Pathogenic hemizygous variants in the SH2D1A gene cause X-linked lymphoproliferative (XLP) syndrome, a rare primary immunodeficiency usually associated with fatal Epstein-Barr virus infection. Disease onset is typically in early childhood, and the average life expectancy of affected males is ∼11 years. We describe clinical, radiographic, neuropathologic, and genetic features of a 49-year-old man presenting with central nervous system vasculitis that was reminiscent of adult primary angiitis but which was unresponsive to treatment. Read More

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https://academic.oup.com/jnen/article/78/5/460/5445919
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http://dx.doi.org/10.1093/jnen/nlz018DOI Listing
May 2019
1 Read

Concentration and Glycoform of Rituximab in Plasma of Patients with B Cell Non-Hodgkin's Lymphoma.

Pharm Res 2019 Apr 15;36(6):82. Epub 2019 Apr 15.

Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Purpose: Therapeutic antibodies have heterogeneities in their structures, although its structural alteration in the body is unclear. Here, we analyzed the change of amino acid modifications and carbohydrate chains of rituximab after administration to patients.

Methods: Twenty B cell non-Hodgkin's lymphoma patients who were treated with rituximab for the first time or after more than one year's abstinence were recruited. Read More

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http://dx.doi.org/10.1007/s11095-019-2624-5DOI Listing
April 2019
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Rare presentation of disseminated follicular lymphoma as an ill-defined reticular patch over the scalp and forehead.

JAAD Case Rep 2019 Apr 2;5(4):319-322. Epub 2019 Apr 2.

Department of Dermatology, Harbor UCLA Medical Center, Torrance, California.

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http://dx.doi.org/10.1016/j.jdcr.2019.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447722PMC

Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-κB signaling pathway.

Exp Ther Med 2019 May 20;17(5):4080-4088. Epub 2019 Mar 20.

Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.

Nano-sized hydroxyapatite (nHA) particles have been demonstrated to exert anti-cancer effects on multiple cancer cell lines and animal models of cancer biology. However, the molecular mechanism underlying the effects of nHA particles on glioma cells remains unclear. The present study aimed to examine the effects of nHA on the behavior of glioma cells and investigate its underlying molecular mechanism. Read More

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http://dx.doi.org/10.3892/etm.2019.7418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447934PMC

BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway.

Exp Ther Med 2019 May 18;17(5):3848-3858. Epub 2019 Mar 18.

CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, Shandong 266071, P.R. China.

The novel bromophenol derivative, 3-(3-bromo-5-methoxy-4-(3-(piperidin-1-yl)propoxy)benzylidene)--(4-bromophenyl)-2-oxoindoline-5-sulfonamide (BOS-93), was synthesized in the CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences (Qingdao, China). Experimental studies have demonstrated that it could induce apoptosis and autophagy in human A549 lung cancer cells, and it could also inhibit tumor growth in human A549 lung cancer xenograft models. In the present study, the molecular pathways underlying these effects were identified. Read More

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http://dx.doi.org/10.3892/etm.2019.7402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447907PMC

Liraglutide, a glucagon-like peptide-1 analog, inhibits high glucose-induced oxidative stress and apoptosis in neonatal rat cardiomyocytes.

Exp Ther Med 2019 May 13;17(5):3734-3740. Epub 2019 Mar 13.

Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.

Cardiomyocyte apoptosis serves an important role in diabetic cardiomyopathy. Liraglutide, a glucagon-like peptide-1 analog, has been indicated to exert a cardioprotective effect. However, the role of liraglutide on cardiomyocyte apoptosis in hyperglycemia is not fully understood. Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7388
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http://dx.doi.org/10.3892/etm.2019.7388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447768PMC
May 2019
1 Read

Ginsenoside Rb1 protects cardiomyocytes from oxygen-glucose deprivation injuries by targeting microRNA-21.

Exp Ther Med 2019 May 1;17(5):3709-3716. Epub 2019 Mar 1.

Department of Cardiology, Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.

Ginsenoside Rb1 (GS-Rb1) is one of the most important active pharmacological extracts of the traditional Chinese medicine, ginseng, and there is extensive evidence of its cardioprotective properties. However, the microRNA (miR) targets of GS-Rb1 and the underlying mechanisms of GS-Rb1 and miR-21 in the progression of cardiomyocyte apoptosis have not been clearly elucidated. The aim of the current study was to investigate the impact of miR-21 and its target gene, programmed cell death protein 4 (PDCD4), on the protective effect of GS-Rb1 in cardiomyocytes injured by oxygen-glucose deprivation (OGD). Read More

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http://dx.doi.org/10.3892/etm.2019.7330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447784PMC

The expression level of hsa-miR-146a-5p in plasma-derived exosomes of patients with diffuse large B-cell lymphoma.

J Res Med Sci 2019 25;24:10. Epub 2019 Feb 25.

Department of Physiology, School of Medicine and Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The standard treatment for patients with diffuse large B-cell lymphoma (DLBCL) had been rituximab-based immunochemotherapy. However, the biological and clinical heterogeneity within DLBCL seems to affect treatment outcome. Therefore, the evaluation of miRNA levels might be useful in predicting treatment response and relapse risk. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_507_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421886PMC
February 2019

Leg Type Primary Cutaneous Diffuse Large B-Cell Lymphoma.

Indian J Hematol Blood Transfus 2019 Apr 29;35(2):378-379. Epub 2018 Oct 29.

Pathology Unit, IRCCS Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.

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http://dx.doi.org/10.1007/s12288-018-1036-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439055PMC

Blockade of HMGB1 signaling pathway by ethyl pyruvate inhibits tumor growth in diffuse large B-cell lymphoma.

Cell Death Dis 2019 Apr 15;10(5):330. Epub 2019 Apr 15.

Department of Radiotherapy, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

High mobility group box 1 (HMGB1) protein in the tumor microenvironment actively contributes to tumor progression but its role in diffuse large B-cell lymphoma (DLBCL) is unknown. The aim of this study was to determine the mechanism by which HMGB1 promotes tumor growth in DLBCL and whether blockade of HMGB1 signaling pathway could inhibit tumorigenesis. We report that HMGB1 promotes proliferation of DLBCL cells by activation of AKT, extracellular signal-regulated kinases 1/2 (ERK1/2), signal transducer and activator of transcription 3 (STAT3) and SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase (Src). Read More

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http://dx.doi.org/10.1038/s41419-019-1563-8DOI Listing

Clinicopathological spectrum of renal parenchymal involvement in B-cell lymphoproliferative disorders.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Department of Nephrology and Renal Transplantation, Centre Hospitalier Universitaire, Université de Poitiers, Poitiers, France; CNRS UMR 7276, INSERM UMR 1262, Université de Limoges, Limoges, France; INSERM CIC 1402, Centre Hospitalier Universitaire, Poitiers, France.

The clinicopathological characteristics of kidney infiltration in B-cell lymphoproliferative disorders remain poorly described. We retrospectively studied 52 adults with biopsy-proven malignant B-cell kidney infiltration, including Waldenström's macroglobulinemia (n=21), chronic lymphocytic leukemia (n=11), diffuse large B-cell lymphoma (DLBCL) (n=8), other lymphoma (n=11), and multiple myeloma (n=1). Kidney disease varied according to the underlying lymphoproliferative disorder. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.027DOI Listing

Bilateral mantle cell lymphoma of the ciliary body that responded to a combined local radiotherapy and chemotherapy regimen: a case report.

BMC Cancer 2019 Apr 15;19(1):355. Epub 2019 Apr 15.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) that often affects men over the age of 60. Systemic metastasis of MCL to eyes is rare and intraocular involvement is even rarer, which usually affects the choroid and iris. To the best of our knowledge, ciliary body metastasis of systemic MCL has not been reported. Read More

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http://dx.doi.org/10.1186/s12885-019-5530-7DOI Listing

[Viral Hepatitis: When to be Considered in Clinical Routine?]

Dtsch Med Wochenschr 2019 Apr 15;144(8):520-527. Epub 2019 Apr 15.

Chronic viral hepatitis can remain unrecognized but may nevertheless lead to liver cirrhosis and hepatocellular carcinoma. Thus, patients with elevated liver enzymes as well as risk groups need to be screened and treated for viral hepatitis. These groups include, in particular, migrants from countries with high HBV or HCV prevalence, persons with previous or current intravenous drug use, and homosexual men. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0640-3627
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http://dx.doi.org/10.1055/a-0640-3627DOI Listing
April 2019
1 Read

Richter syndrome epidemiology in a large population based chronic lymphocytic leukemia cohort from Norway.

Cancer Epidemiol 2019 Apr 12;60:128-133. Epub 2019 Apr 12.

Department of Haematology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; K.G. Jebsen Centre for B-Cell malignancies, University of Oslo, Oslo, Norway.

Background: Transformation to aggressive lymphoma (Richter syndrome, RS) occurs in a substantial subset of patients who must discontinue targeted therapy for chronic lymphocytic leukemia (CLL). RS has an extremely poor prognosis.

Methods: Using the nation-wide database of The Cancer Registry of Norway of 7664 CLL patients registered between 1953-2012, we identified 107 patients experiencing RS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18777821183046
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http://dx.doi.org/10.1016/j.canep.2019.04.002DOI Listing
April 2019
1 Read

Avicularin Relieves Depressive-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice.

Med Sci Monit 2019 Apr 15;25:2777-2784. Epub 2019 Apr 15.

College of Medicine, Jiaxing University, Jiaxing, Zhejiang, China (mainland).

BACKGROUND Avicularin (AL, quercetin-3-alpha-l-arabinofuranoside), a glycoside of quercetin, has been reported to display diverse pharmacological properties. The present study aimed to investigate whether AL has an anti-depressant-like effect on a mouse model of depression induced by chronic unpredictable mild stress (CUMS). MATERIAL AND METHODS A mouse model of depression was established and treated with different concentrations of AL (1. Read More

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http://dx.doi.org/10.12659/MSM.912401DOI Listing

Clinical spectrum, evolution and management of autoimmune cytopenias associated with angioimmunoblastic T-cell lymphoma.

Eur J Haematol 2019 Apr 15. Epub 2019 Apr 15.

Service de médecine interne, Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Est, Créteil, France.

Objective: Angioimmunoblastic T-cell lymphoma (AITL) are frequently associated with autoimmune cytopenia (AIC). Whether such patients have a particular phenotype and require particular management is unclear.

Method: AITL patients from the multicentric database of the Lymphoma Study Association presenting with AIC during disease course were included and matched to AITL patients without AIC (1/5 ratio). Read More

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http://dx.doi.org/10.1111/ejh.13239DOI Listing

CD20-negative primary middle ear diffuse large B-cell lymphoma coexpressing MYC and BCL-2 secondary to acute lymphoblastic leukemia: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15204

Department of Hematology, The First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan Province, China.

Rationale: Second diffuse large B-cell lymphoma (DLBCL) after treatment of acute lymphoblastic leukemia (ALL) is uncommon. To our knowledge, primary middle ear DLBCL which presents CD20-negative and coexpression of MYC and BCL-2 has not been reported yet.

Patient Concerns: A 20-year-old Chinese man complained fever and weakness for 2 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000015204DOI Listing

MicroRNA-related transcription factor regulatory networks in human colorectal cancer.

Medicine (Baltimore) 2019 Apr;98(15):e15158

Department of Medical Research Center.

Objective: Colorectal cancer (CRC) is an extremely common gastrointestinal malignancy. The present study aimed to identify microRNAs (miRNAs) and transcription factors (TFs) associated with tumor development.

Methods: Three miRNA profile datasets were integrated and analyzed to elucidate the potential key candidate miRNAs in CRC. Read More

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http://dx.doi.org/10.1097/MD.0000000000015158DOI Listing
April 2019
2 Reads

Diffuse large B-cell lymphoma involving peripheral nervous system with IgM antibodies against GM1 and GD1b: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15049

Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, Jilin, China.

Rationale: The occurrence of peripheral neuropathy associated with non-Hodgkin's lymphoma (NHL) is uncommon. And autoimmunity may play an important role. We report a case of the patient with NHL, has sensorimotor demyelinating polyneuropathy. Read More

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http://dx.doi.org/10.1097/MD.0000000000015049DOI Listing
April 2019
1 Read

Investigation of lymphoid lesions of the Head and Neck using combined fine needle aspiration cytology and flow cytometry: accuracy and pitfalls.

Cytopathology 2019 Apr 15. Epub 2019 Apr 15.

Cytology Department, Sullivan Nicolaides Pathology, 24 Hurworth St, Bowen Hills, 4006.

Objective: We reviewed the diagnostic utility of combined fine needle aspiration cytology (FNAC) and flow cytometry (FC) in the diagnosis of lymphoid lesions of the head and neck.

Method: 1402 patients with combined FNAC-FC reports were correlated with follow-up information. Rapid on-site evaluation (ROSE) of cytological specimens was performed in 52% of cases. Read More

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http://dx.doi.org/10.1111/cyt.12706DOI Listing

Dermoscopy of Primary Cutaneous B-cell Lymphoma.

Indian Dermatol Online J 2019 Mar-Apr;10(2):208-209

Department of Dermatology, Mayo Clinic, Jacksonville, Florida, USA.

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http://dx.doi.org/10.4103/idoj.IDOJ_39_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434743PMC

A case of pulmonary lymphoproliferative disorder presenting rapidly progressive respiratory failure.

Respirol Case Rep 2019 Jul 2;7(5):e00422. Epub 2019 Apr 2.

Division of Respiratory Medicine, Center for Respiratory Diseases National Hospital Organization Kyoto Medical Center Kyoto Japan.

A 72-year-old woman presented with acute onset of shortness of breath and fatigue over several days, and was found to be in acute respiratory failure. Computed tomography of the chest revealed diffuse ground-glass opacities, crazy-paving, multiple nodules, and a large mass in the right lower lobe. She was diagnosed with B-cell lymphoma and a pulmonary lymphoproliferative disorder (PLD). Read More

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http://dx.doi.org/10.1002/rcr2.422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444548PMC

The Neuroprotective Effect of Astaxanthin on Pilocarpine-Induced Status Epilepticus in Rats.

Front Cell Neurosci 2019 29;13:123. Epub 2019 Mar 29.

Department of Endocrinology, Jinshan Hospital, Fudan University, Shanghai, China.

Cognitive dysfunction is one of the serious complications induced by status epilepticus (SE), which has a significant negative impact on patients' quality of life. Previous studies demonstrated that the pathophysiological changes after SE such as oxidative stress, inflammatory reaction contribute to neuronal damage. A recent study indicated that preventive astaxanthin (AST) alleviated epilepsy-induced oxidative stress and neuronal apoptosis in the brain. Read More

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https://www.frontiersin.org/article/10.3389/fncel.2019.00123
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http://dx.doi.org/10.3389/fncel.2019.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449650PMC
March 2019
1 Read

Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis.

Elife 2019 Apr 15;8. Epub 2019 Apr 15.

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, United States.

Transcription is tightly regulated to maintain energy homeostasis during periods of feeding or fasting, but the molecular factors that control these alternating gene programs are incompletely understood. Here, we find that the B cell lymphoma 6 (BCL6) repressor is enriched in the fed state and converges genome-wide with PPARα to potently suppress the induction of fasting transcription. Deletion of hepatocyte enhances lipid catabolism and ameliorates high-fat-diet-induced steatosis. Read More

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https://elifesciences.org/articles/43922
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http://dx.doi.org/10.7554/eLife.43922DOI Listing
April 2019
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Extranasal extranodal NK/T cell lymphoma: A post-transplantation lymphoproliferative disease.

Int Wound J 2019 Apr 14. Epub 2019 Apr 14.

Department of Dermatology, Medical Faculty, Ege University, Izmir, Turkey.

Extranodal NK/T cell lymphoma (ENKTL) is a rare form of non-Hodgkin lymphoma. It mostly occurs in the upper respiratory tract. Cutaneous involvement can be seen among the extranasal ENKTLs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/iwj.13126
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http://dx.doi.org/10.1111/iwj.13126DOI Listing
April 2019
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Hepatitis C Virus Infection and Non-Hepatocellular Malignancies in the DAA Era: A Systematic Review and Meta-Analysis.

Liver Int 2019 Apr 15. Epub 2019 Apr 15.

Internal Medicine and Hepatology Unit, University of Salerno, Salerno, Italy.

Background And Aims: Direct antiviral agents have greatly improved therapeutic options for chronic hepatitis C. Indeed, former "difficult-to-treat" patients can now be treated and can achieve sustained response. HCV is associated with hepatocellular carcinoma and with B-cell non-Hodgkin lymphoma(B-NHL). Read More

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http://dx.doi.org/10.1111/liv.14119DOI Listing

The accuracy of diagnosing Burkitt lymphoma in serous effusion specimen: a cytological-histological correlation with ancillary studies.

Cytopathology 2019 Apr 15. Epub 2019 Apr 15.

Department of pathology, West China Hospital of Sichuan University, Chengdu, 610041, China.

Objective: The objective of this study is to evaluate the effectiveness of diagnosing Burkitt lymphoma (BL) in serous effusion (SE) specimen and summarize the characteristics of BL in SE. We also assess the utility of a germinal centre-associated marker, LMO2, in the differential diagnosis of BL in SE specimen.

Methods: Eleven cases of malignant SE caused by BL were reviewed. Read More

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http://dx.doi.org/10.1111/cyt.12707DOI Listing

Biophysical Characterization of a Nanodisc with and without BAX: An Integrative Study Using Molecular Dynamics Simulations and Cryo-EM.

Structure 2019 Apr 10. Epub 2019 Apr 10.

Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Electronic address:

B cell lymphoma-2-associated X protein (BAX) plays a pivotal role in triggering cell apoptosis by permeabilizing the mitochondrial outer membrane. Contrary to previous findings, recent electron microscopy (EM) experiments showed that BAX monomers are able to perturb phospholipid nanodiscs (NDs) by forming lipidic pores. Here, we provide structural and thermodynamic interpretation of such data using multiscale resolution molecular dynamics (MD) simulations. Read More

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http://dx.doi.org/10.1016/j.str.2019.03.013DOI Listing

TRPM4 channel and cancer.

Authors:
Yahui Gao Ping Liao

Cancer Lett 2019 Apr 10;454:66-69. Epub 2019 Apr 10.

Calcium Signalling Laboratory, National Neuroscience Institute, Singapore; Duke-NUS Medical School, Singapore; Health and Social Sciences, Singapore Institute of Technology, Singapore. Electronic address:

The TRPM4 channel has been extensively studied in cerebral diseases such as stroke, head injury and multiple sclerosis. In the heart, gain-of-function mutations of TRPM4 are a cause of familial cardiac block. Recently, evidence has emerged to support the role of TRPM4 in certain types of cancer, such as prostate cancer and large B cell lymphoma. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.04.012DOI Listing

Bendamustine for patients with indolent B cell lymphoproliferative malignancies including chronic lymphocytic leukaemia - an updated meta-analysis.

Br J Haematol 2019 Apr 13. Epub 2019 Apr 13.

Tel Aviv University, Tel Aviv.

The question of which chemotherapy induction provides the best results for indolent lymphoma patients is yet unanswered. Different regimens have been compared, none of which has been shown to improve overall survival. The use of bendamustine is growing. Read More

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http://dx.doi.org/10.1111/bjh.15901DOI Listing
April 2019
2 Reads

Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma.

Blood Adv 2019 Apr;3(8):1230-1243

Division of Cancer Medicine, Department of Cellular Therapy, and.

T cells modified to express chimeric antigen receptor (CAR) targeting CD19 (CD19CAR) have produced remarkable clinical responses in patients with relapsed/refractory B-cell acute lymphoblastic leukemia. CD19CAR T-cell therapy has also demonstrated prominent effects in B-cell non-Hodgkin lymphoma (B-NHL) patients. However, a subset of patients who relapse after CD19CAR T-cell therapy have outgrowth of CD19 tumor cells. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018029678DOI Listing
April 2019
2 Reads

Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells.

Immunity 2019 Apr 4. Epub 2019 Apr 4.

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with epithelial-cell cancers and B cell lymphomas. An effective EBV vaccine is not available. We found that antibodies to the EBV glycoprotein gH/gL complex were the principal components in human plasma that neutralized infection of epithelial cells and that antibodies to gH/gL and gp42 contributed to B cell neutralization. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.03.010DOI Listing

Intraocular involvement of Mantle cell lymphoma: A case report and literature review.

Hematol Oncol Stem Cell Ther 2019 Apr 6. Epub 2019 Apr 6.

Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL, USA.

Lymphomatous involvement of the ocular adnexal region (OAR) is generally rare; however, it constitutes the most common ocular malignancy. Most cases of ocular adnexal lymphomas are extra nodal marginal zone B cell lymphomas. Mantle cell lymphoma involvement (MCL) of the OAR is a less common presentation compared with other lymphomas and it has been reported anecdotally. Read More

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http://dx.doi.org/10.1016/j.hemonc.2019.03.002DOI Listing
April 2019
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Non-Hodgkin Lymphoma in the Middle East Is Characterized by Low Incidence Rates With Advancing Age.

J Glob Oncol 2019 Apr(5):1-10

3 Shorsh General and Hiwa Cancer Hospitals, Sulaimaniyah, Iraq.

Purpose: In the Middle East, incidence rate ratios (IRRs) of non-Hodgkin lymphoma (NHL) to Hodgkin lymphoma (HL) are more than 50% lower than the United States.

Materials And Methods: Age-specific incidence rates (ASIRs), age-adjusted incidence rates (AAIRs), and IRRs of NHL:HL were compared using the cancer registries of Iraq, Jordan, Saudi Arabia, and US SEER.

Results: The NHL AAIR (95% CI) per 100,000 population was 4. Read More

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http://dx.doi.org/10.1200/JGO.18.00241DOI Listing
April 2019
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Fibrin-associated diffuse large B-cell lymphoma arising in a mature cystic teratoma: A case report.

Pathol Int 2019 Apr 12. Epub 2019 Apr 12.

Department of Gastroenterology, Chikamori Hospital, Kochi, Japan.

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http://dx.doi.org/10.1111/pin.12788DOI Listing
April 2019
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Seroepidemiological analysis and literature review of the prevalence of Epstein-Barr virus and herpesvirus infections in pediatric cases with non-Hodgkin lymphoma in Central Europe.

Pediatr Blood Cancer 2019 Apr 12:e27752. Epub 2019 Apr 12.

Department of Pediatric Hematology and Oncology, Justus Liebig University Giessen, Giessen, Germany.

Background: Epstein-Barr virus (EBV) is linked to a variety of malignancies; most endemic Burkitt lymphoma (BL) harbor EBV, whereas only a subset of the cases of sporadic BL is EBV positive.

Procedure: We retrospectively determined the herpesvirus seroprevalence at the time of diagnosis in pediatric non-Hodgkin lymphoma (NHL) patients enrolled in NHL-BFM (Berlin-Frankfurt-Muenster) studies. We accessed the seroepidemiological data from 1147 patients that became available during 1990-2007. Read More

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http://dx.doi.org/10.1002/pbc.27752DOI Listing
April 2019
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Astrakurkurone, a Sesquiterpenoid from Wild Edible Mushroom, Targets Liver Cancer Cells by Modulating Bcl-2 Family Proteins.

IUBMB Life 2019 Apr 12. Epub 2019 Apr 12.

Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, WB, India.

Induction of apoptosis is the target of choice for modern chemotherapeutic treatment of cancer, where lack of potent "target-specific" drugs has led to extensive research on anticancer compounds from natural sources. In our study, we have used astrakurkurone, a triterpene isolated from wild edible mushroom, Astraeus hygrometricus. We have discussed the structure and stability of astrakurkurone employing single-crystal X-ray crystallography and studied its potential apoptogenicity in hepatocellular carcinoma (HCC) cells. Read More

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http://dx.doi.org/10.1002/iub.2047DOI Listing
April 2019
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Mesenchymal Stem Cells: a Promising Therapeutic Tool for Acute Kidney Injury.

Appl Biochem Biotechnol 2019 Apr 12. Epub 2019 Apr 12.

Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Acute kidney injury (AKI) is a rapid loss of renal function. It has high mortality rates. Still, renal replacement therapy is considered the best solution for recovering AKI. Read More

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http://dx.doi.org/10.1007/s12010-019-02995-2DOI Listing
April 2019
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B-cell central nervous system lymphoma developing in a patient with cerebral meningioangiomatosis.

Radiol Case Rep 2019 May 25;14(5):538-543. Epub 2019 Feb 25.

Department of Advanced Biomedical Sciences, Neuroradiology Unit, University "Federico II", Via Pansini, 5, 80131 Naples, Italy.

Meningioangiomatosis is a rare congenital hamartomatous malformation of the leptomeninges that can also involve the adjacent cerebral tissue, sometime arising in association with neurofibromatosis. Here we report the case of a 55-year-old man with neuroradiological evidence of meningioangiomatosis, known to be a well-defined malformative-dysplastic lesion, preceding the onset of central nervous system B-cell lymphoma. We describe for the first time this unusual association, highlighting how meningioangiomatosis could accompany different pathologies more frequently than thought. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443910PMC
May 2019
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IBTK contributes to B-cell lymphomagenesis in Eμ-myc transgenic mice conferring resistance to apoptosis.

Cell Death Dis 2019 Apr 11;10(4):320. Epub 2019 Apr 11.

Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, 88100, Italy.

Increasing evidence supports the involvement of IBTK in cell survival and tumor growth. Previously, we have shown that IBTK RNA interference affects the wide genome expression and RNA splicing in cell-type specific manner. Further, the expression of IBTK gene progressively increases from indolent to aggressive stage of chronic lymphocytic leukemia and decreases in disease remission after therapy. Read More

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http://dx.doi.org/10.1038/s41419-019-1557-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459904PMC
April 2019
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Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells.

Haematologica 2019 Apr 11. Epub 2019 Apr 11.

University Hospital Brno and Faculty of Medicine, Masaryk University;

Introduction of small-molecule inhibitors of B-cell receptor signaling and BCL2 protein significantly improves therapeutic options in chronic lymphocytic leukemia. However, some patients suffer from adverse effects mandating treatment discontinuation, and cases with TP53 defects more frequently experience early progression of the disease. Development of alternative therapeutic approaches is therefore of critical importance. Read More

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http://dx.doi.org/10.3324/haematol.2018.203430DOI Listing
April 2019
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