74,715 results match your criteria Lymphoma B-Cell


Long-term Survival and Cost-effectiveness Associated With Axicabtagene Ciloleucel vs Chemotherapy for Treatment of B-Cell Lymphoma.

JAMA Netw Open 2019 Feb 1;2(2):e190035. Epub 2019 Feb 1.

Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora.

Importance: Axicabtagene ciloleucel, a chimeric antigen receptor T-cell therapy, represents a new and potentially curative treatment option for B-cell lymphoma. It is expected to have long-term survival benefits; however, long-term survival data are limited.

Objective: To estimate the long-term survival and cost-effectiveness of axicabtagene ciloleucel for treatment of relapsed or refractory B-cell lymphoma. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.0035DOI Listing
February 2019

Management of cytokine release syndrome and neurotoxicity in chimeric antigen receptor T-cell therapy.

Expert Rev Hematol 2019 Feb 22. Epub 2019 Feb 22.

a Division of Medical Oncology, Department of Internal Medicine , University of Washington School of Medicine , Seattle , WA , USA.

Introduction: Chimeric antigen receptor (CAR) T cell immunotherapy has demonstrated remarkable anti-tumor activity in B-cell malignancies and is under investigation in other hematologic malignancies and solid tumors. While highly efficacious, post-infusion T cell activity often results in massive cytokine release precipitating cytokine release syndrome (CRS), the signature toxicity of CAR T cells. This toxicity is characterized by systemic immune activation resulting in fever, hypotension, respiratory insufficiency and capillary leak. Read More

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http://dx.doi.org/10.1080/17474086.2019.1585238DOI Listing
February 2019

Prognostic impact of mutation, proliferative index and cell origin in diffuse large B cell lymphoma.

Hematol Transfus Cell Ther 2019 Jan-Mar;41(1):50-56. Epub 2018 Oct 24.

Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil.

Background: Diffuse large B-cell lymphoma, among non-Hodgkin lymphomas, is one of the most frequent subtypes. Clinical laboratory data and post-treatment outcomes are scarce in the Brazilian population.

Objective: The main objective of this retrospective study was to assess the impact of tumor markers, including the Myeloid differentiation primary response 88 (MYD88) mutation. Read More

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http://dx.doi.org/10.1016/j.htct.2018.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371411PMC
October 2018

CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type.

Case Rep Dermatol Med 2019 16;2019:3730915. Epub 2019 Jan 16.

Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted because of a nodule at the left thigh. Read More

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http://dx.doi.org/10.1155/2019/3730915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354159PMC
January 2019

Inheritance of Susceptibility to Malignant Blood Disorders.

Sci Rep 2019 Feb 21;9(1):2444. Epub 2019 Feb 21.

Department of Hematology, Oslo University Hospital, KG Jebsen Center for B cell malignancies P.O. box 4950, Nydalen, NO 0424, Oslo, Norway.

Malignant blood disorders depend on heritable susceptibility genes and occur in familial aggregations. We suggest a model of transgenerational segregation of the susceptibility genes based on the study of malignant blood disorders in Norwegian and Danish families with unrelated parents, and in the inbred Faroese population with related parents. This model, consisting of parental genomic imprinting and mother-son microchimerism, can explain the male predominance in most of the diseases, the predominance of affected parent-offspring when parents are not related, and the different modes of segregation in males and females. Read More

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http://dx.doi.org/10.1038/s41598-019-38879-yDOI Listing
February 2019

BCL-2 family isoforms in apoptosis and cancer.

Cell Death Dis 2019 Feb 21;10(3):177. Epub 2019 Feb 21.

Hunter Medical Research Institute, Newcastle, NSW, Australia.

The BCl-2 family has long been identified for its role in apoptosis. Following the initial discovery of BCL-2 in the context of B-cell lymphoma in the 1980s, a number of homologous proteins have since been identified. The members of the Bcl-2 family are designated as such due to their BCL-2 homology (BH) domains and involvement in apoptosis regulation. Read More

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http://dx.doi.org/10.1038/s41419-019-1407-6DOI Listing
February 2019

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering.

Haematologica 2019 Feb 21. Epub 2019 Feb 21.

University of Virginia School of Medicine, Charlottesville, Virginia, USA.

CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However many patients acquire resistance, demonstrating the need for new and improved drugs. We previously demonstrated that the natural process of antibody hexamer formation on targeted cells allows for optimal induction of complement-dependent cytotoxicity. Read More

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http://dx.doi.org/10.3324/haematol.2018.207266DOI Listing
February 2019

A good response of refractory mantel cell lymphoma to haploidentical CAR T cell therapy after failure of autologous CAR T cell therapy.

J Immunother Cancer 2019 Feb 21;7(1):51. Epub 2019 Feb 21.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: The aggressive form of Mantle cell non-hodgkin B cell lymphoma (MCL) has a dismal prognosis. Dual targeting BTK and BCL2 with ibrutinib and venetoclax has improved outcomes in MCL patients who were predicted not to respond to conventional therapy, but it is unlikely to be curative. Chimeric antigen receptor-modified T (CAR T) cells exhibit very effective function in elimination of relapsed/refractory B-cell lymphoid malignancies, we investigated their use in a patient with relapsed MCL. Read More

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http://dx.doi.org/10.1186/s40425-019-0529-9DOI Listing
February 2019

The impact of early diagnosis on the prognosis of extranodal NK/T-cell lymphoma with massive lung involvement: a case report.

BMC Pulm Med 2019 Feb 21;19(1):48. Epub 2019 Feb 21.

Department of Hematology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan.

Background: Pulmonary non-Hodgkin lymphoma (NHL) is rare. The most frequent subtype of pulmonary NHL is low-grade B-cell lymphoma, such as lymphoma of mucosa-associated lymphoma tissue. Extranodal natural killer cell/T-cell lymphoma, nasal type (ENKL) is characterized by predominant extranodal involvement and association with Epstein-Barr virus (EBV). Read More

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http://dx.doi.org/10.1186/s12890-019-0815-9DOI Listing
February 2019

Serum level of soluble interleukin-2 receptor is positively correlated with metabolic tumor volume on F-FDG PET/CT in newly diagnosed patients with diffuse large B-cell lymphoma.

Cancer Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Hematology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin lymphoma. High total metabolic tumor volume (TMTV) calculated using F-FDG PET/CT images at diagnosis predicts poor prognosis of patients with DLBCL. However, high cost and poor access to the imaging facilities hamper wider use of F-FDG PET/CT. Read More

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http://dx.doi.org/10.1002/cam4.1973DOI Listing
February 2019

Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma.

Cell Oncol (Dordr) 2019 Feb 21. Epub 2019 Feb 21.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.

Purpose: Increased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role of glycolytic metabolism-related molecules in lymphoma is not well known. Read More

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http://dx.doi.org/10.1007/s13402-019-00426-2DOI Listing
February 2019

[Effects of irbesartan on Notch1 signaling pathway in diabetic rats with myocardial injury].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2018 May;34(5):427-431

Department of Cardiovascular Medicine, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004.

Objective: To investigate the effects and mechanisms of irbesartan on myocardial injury in diabetic rats, and to analyze the changes of Notch1 signaling pathway in it.

Methods: Thirty rats were randomly divided into four groups:normal control group (CON, =6), high calorie group (HC, =6) and diabetes mellitus group (DM, =9), irbesartan + diabetes group (Ir + DM, =9). After modeling 8 weeks later, the body weight ratio and left ventricular weight index were measured and the serum levels of triglyceride (TG) and total cholesterol (TC) were measured by automatic biochemical analyzer. Read More

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http://dx.doi.org/10.12047/j.cjap.5674.2018.097DOI Listing

Small Bowel Volvulus Caused by Small Intestinal B Cell Lymphoma.

J Gastrointest Surg 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, Division of Surgical Oncology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA.

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http://dx.doi.org/10.1007/s11605-019-04125-zDOI Listing
February 2019

Immunochemotherapy for Richter syndrome: current insights.

Immunotargets Ther 2019 5;8:1-14. Epub 2019 Feb 5.

Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland,

Richter syndrome (RS) is recognized as the development of a secondary and aggressive lymphoma during the clinical course of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Most of such histological transformations are from RS to diffuse large B-cell lymphoma (DLBCL-RS, 90%) and Hodgkin's lymphoma (HL-RS, 10%). Histopathological examination is a prerequisite for diagnosis. Read More

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http://dx.doi.org/10.2147/ITT.S167456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368420PMC
February 2019

Rare case of primary extranodal marginal zone lymphoma of the thorax.

Respir Med Case Rep 2019 8;26:251-254. Epub 2019 Feb 8.

Pulmonology Department, Fattouma Bourguiba Hospital, Monastir, Tunisia.

Primary lymphoma presenting a solitary lesion of the chest wall is extremely rare, as the majority of chest-wall tumors arise from metastasis. We report a case of a 64-year-old man with no history of HIV infection or pyothorax who presented with dry cough, right pleuritic pain and dyspnea. A computed tomography scan revealed an irregular pleural mass invading his right chest wall with pleural effusion. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369120PMC
February 2019

Primary Vaginal Non-Hodgkin Lymphoma.

Cureus 2018 Dec 11;10(12):e3713. Epub 2018 Dec 11.

Internal Medicine, Universidad Nacional Mayor De San Marcos, Lima, PER.

Non-Hodgkin lymphoma (NHL) is a type of blood cancer and 25% of NHL patients present with a primary extranodal tumor. Primary NHL of the vagina is extremely rare with only a few cases reported. We present the case of a 79-year-old, grand multipara, Peruvian woman with an eleven-month history of symptoms of pelvic and vaginal pain and vaginal bleeding. Read More

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http://dx.doi.org/10.7759/cureus.3713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373882PMC
December 2018

Bivalent Ligands for Protein Degradation in Drug Discovery.

Comput Struct Biotechnol J 2019 25;17:160-176. Epub 2019 Jan 25.

Mercachem BV, Kerkenbos 1013, 6546 BB, Nijmegen, the Netherlands.

Targeting the "undruggable" proteome remains one of the big challenges in drug discovery. Recent innovations in the field of targeted protein degradation and manipulation of the ubiquitin-proteasome system open up new therapeutic approaches for disorders that cannot be targeted with conventional inhibitor paradigms. Proteolysis targeting chimeras (PROTACs) are bivalent ligands in which a compound that binds to the protein target of interest is connected to a second molecule that binds an E3 ligase via a linker. Read More

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http://dx.doi.org/10.1016/j.csbj.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369262PMC
January 2019

Adult Burkitt lymphoma- an Island between lymphomas and leukemias.

J Community Hosp Intern Med Perspect 2019 11;9(1):25-28. Epub 2019 Feb 11.

Department of Internal Medicine, Hackensack Meridian Health- Ocean Medical Centre, Brick, NJ, USA.

: Burkitt lymphoma is a rare, aggressive and rapidly fatal, B-cell non-Hodgkin's lymphoma. It has an incidence of 0.4/100,000 age-adjusted to the USA standard population. Read More

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http://dx.doi.org/10.1080/20009666.2019.1574545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374956PMC
February 2019

Folding/unfolding kinetics of G-quadruplexes upstream of the P1 promoter of the human oncogene.

J Biol Chem 2019 Feb 20. Epub 2019 Feb 20.

Huazhong University of Science and Technology, China.

The G-rich Pu39 region of the P1 promoter of the oncogene , an apoptosis regulator, can fold into multiple G-quadruplex (G4) structures. Bcl2-2345 and Bcl2-1245 are two major G4 species forming with high thermal stability and distinct topologies in the Pu39 region, but their folding/unfolding kinetics have not yet been investigated. Here, we used magnetic tweezers to measure the mechanical stability and the folding/unfolding kinetics of the Bcl2-2345 and Bcl2-1245 G4 structures. Read More

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http://dx.doi.org/10.1074/jbc.RA119.007516DOI Listing
February 2019

Cells of adult T-cell leukemia evade HTLV-1 Tax/NF-κB hyperactivation-induced senescence.

Blood Adv 2019 Feb;3(4):564-569

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD.

Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATL). The HTLV-1 viral -activator/oncoprotein Tax is a major driver of ATL, yet it induces rapid p21 (p21)- and p27-mediated cellular senescence through constitutive activation (hyperactivation) of NF-κB. Although constitutive NF-κB activation is a common feature of T/B-cell leukemia/lymphoma, including ATL, it is not known how ATL cells maintain chronic NF-κB activation without undergoing senescence. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018029322DOI Listing
February 2019

Mass Cytometry Analysis Reveals that Specific Intratumoral CD4 T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma.

Cell Rep 2019 Feb;26(8):2178-2193.e3

Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address:

Follicular lymphoma (FL) is an indolent B cell malignancy characterized by an extensive but poorly functional T cell infiltrate in the tumor microenvironment. Using mass cytometry, we identified at least 12 subsets of intratumoral CD4 T cells, 3 of which were unique to FL biopsies versus control tissues. Of these subsets, the frequency of naive T cells correlated with improved patient survival. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.085DOI Listing
February 2019

KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR-1470 and epidermal growth factor receptor.

J Cell Physiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China.

Long noncoding RNAs have been reported to play important roles in the pathogenesis of diabetic retinopathy (DR), which has been considered as the most common disease leading to vision loss. However, it is still unclear whether KCNQ1 overlapping transcript 1 (KCNQ1OT1) could affect DR. In this study, regarding quantitative reverse transcription polymerase chain reaction assay, KCNQ1OT1 level was upregulated while microRNA-1470 (miR-1470) was decreased in DR patients and human retinal endothelial cells. Read More

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http://dx.doi.org/10.1002/jcp.28344DOI Listing
February 2019

HOXA1 upregulation is associated with poor prognosis and tumor progression in breast cancer.

Exp Ther Med 2019 Mar 28;17(3):1896-1902. Epub 2018 Dec 28.

Department of Breast Surgery, Dalian Central Hospital Affiliated to Dalian Medical University, Dalian, Liaoning 116033, P.R. China.

Breast cancer (BC) is the most commonly diagnosed cancer and the second leading cause of cancer-associated mortality among females worldwide. As a member of the homeobox (HOX) gene family, HOXA1 is involved in tumor progression and prognosis in several types of human cancer. However, the clinical significance and biological functions of HOXA1 in BC remains unknown. Read More

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http://dx.doi.org/10.3892/etm.2018.7145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364196PMC

Correlation of the expression of inflammatory factors with expression of apoptosis-related genes and , in burned rats.

Exp Ther Med 2019 Mar 20;17(3):1790-1796. Epub 2018 Dec 20.

Department of Burn Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252601, P.R. China.

Correlation of the expression of inflammatory factors with expression of apoptosis-related genes, B-cell lymphoma 2 () and Bcl-2 associated X protein (), in burned rats was investigated. Forty healthy Sprague-Dawley rats were selected and randomly divided into SHAM group (n=10), I° burn group (n=10), II° burn group (n=10) and III° burn group (n=10). Changes in tumor necrosis factor-α (TNF-α), Bax messenger ribonucleic acid (mRNA), Bcl-2 mRNA, Bax protein and Bcl-2 protein expression levels were detected. Read More

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http://dx.doi.org/10.3892/etm.2018.7118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364214PMC

Downregulation of miR-183 inhibits the growth of PANC-1 pancreatic cancer cells and , and increases chemosensitivity to 5-fluorouracil and gemcitabine.

Exp Ther Med 2019 Mar 19;17(3):1697-1705. Epub 2018 Dec 19.

Department of General Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, P.R. China.

Pancreatic cancer (PC) is a common malignancy with a poorly understood pathogenesis. Currently, the efficacy of anti-PC therapies is insufficient, partially due to the chemoresistance of cancer cells. The present study aimed to elucidate the role of miR-183 in the proliferation, apoptosis, and chemosensitivity to 5-fluorouracil and gemcitabine of human PC cells and the associated mechanisms. Read More

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http://dx.doi.org/10.3892/etm.2018.7112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364144PMC
March 2019
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Novel triazole analogs of apigenin-7-methyl ether exhibit potent antitumor activity against ovarian carcinoma cells via the induction of mitochondrial-mediated apoptosis.

Exp Ther Med 2019 Mar 28;17(3):1670-1676. Epub 2018 Dec 28.

Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

Ovarian cancer is one of the main causes of cancer-associated mortality across the world. Currently, ovarian cancer is mainly treated with chemotherapy. However, ovarian cancer is detected at advanced stages and chemotherapy has numerous side effects. Read More

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http://dx.doi.org/10.3892/etm.2018.7138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364180PMC

Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy combined with ganciclovir induces hepatoma cell apoptosis.

Exp Ther Med 2019 Mar 2;17(3):1649-1655. Epub 2019 Jan 2.

Department of General Surgery, Beijing Youan Hospital, Capital Medical University, Beijing 100069, P.R. China.

The present study aimed to examine the apoptotic effects of adenovirus (ADV)-mediated herpes simplex virus thymidine kinase (ADV-TK) combined with ganciclovir (GCV) in tissues obtained from patients with hepatocellular carcinoma in order to provide a theoretical basis for the development of this gene therapy program. Apoptosis detection was conducted using the terminal deoxynucleotidyl-transferase-mediated dUTP nick end labelling assay and the apoptosis index was compared between the experimental; and control groups. Furthermore, the protein expression levels of caspase-3, B-cell lymphoma-2 (Bcl-2), Bcl-2-assoicated protein X (Bax) and nuclear factor (NF)-κB were examined in pathological specimens using immunohistochemical staining. Read More

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http://dx.doi.org/10.3892/etm.2019.7147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364201PMC

The response to lymphodepletion impacts PFS in aggressive non-Hodgkin lymphoma patients treated with CD19 CAR-T cells.

Blood 2019 Feb 19. Epub 2019 Feb 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.

Factors associated with durable remission after CD19 chimeric antigen receptor (CAR)-modified T cell immunotherapy for aggressive B-cell non-Hodgkin lymphoma (NHL) have not been identified. We report multivariable analyses of factors impacting response and progression-free survival (PFS) in aggressive NHL patients treated with cyclophosphamide and fludarabine (Cy/Flu) lymphodepletion followed by 2x10 CD19 CAR-T cells/kg. The best overall response rate (ORR) was 51%, with 40% of patients achieving complete remission (CR). Read More

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http://dx.doi.org/10.1182/blood-2018-11-887067DOI Listing
February 2019

Viral, immunologic, and clinical features of primary effusion lymphoma.

Blood 2019 Feb 19. Epub 2019 Feb 19.

HIV & AIDS Malignancy Branch, Center for Cancer Research (CCR), NCI, Bethesda, MD, United States;

Primary effusion lymphoma (PEL) is an aggressive HIV-associated lymphoma with a relatively poor prognosis in the era of effective HIV therapy. Kaposi sarcoma herpesvirus (KSHV) is the etiologic agent, and approximately 80% of tumors are Epstein Barr virus (EBV) co-infected. A better understanding of how KSHV-related immune dysregulation contributes to the natural history of PEL will improve outcomes. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2019-01
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http://dx.doi.org/10.1182/blood-2019-01-893339DOI Listing
February 2019
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Baseline PET as prognostic index in diffuse large B-cell lymphoma and grade IIIb follicular lymphoma: a retrospective study of a single-centre experience.

Q J Nucl Med Mol Imaging 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Background: International guidelines support performing baseline positron emission tomography (PET) in lymphoma. Metabolic tumor volume (MTV) measurement has been proposed as a good measurement of disease burden. We investigated if MTV at baseline PET can be predictive of complete response (CR) to first line standard chemotherapy in diffuse large B-cell lymphoma (DLBCL) and in follicular lymphoma (FL) grade 3b. Read More

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http://dx.doi.org/10.23736/S1824-4785.19.03130-3DOI Listing
February 2019

The renoprotective effects of naringin and trimetazidine on renal ischemia/reperfusion injury in rats through inhibition of apoptosis and downregulation of micoRNA-10a.

Biomed Pharmacother 2019 Feb 16;112:108568. Epub 2019 Feb 16.

Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; The Persian Gulf Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Renal Ischemia-Reperfusion (IR) injury occurs due to circulatory shock and renal transplantation, leading to mortality and morbidity worldwide. The primary purpose of the current study was to evaluate the renoprotective effects of the naringin (NAR) and trimetazidine (TMZ) on IR injury, renal hemodynamics, antioxidant capacity, microRNA-10a, and expression of apoptosis factors. Forty rats were divided into five groups randomly: Sham, IR injury, (TMZ, 5 mg/kg), (NAR pretreatment, 100 mg/kg), and TMZ plus NAR. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.029DOI Listing
February 2019

CD30 expression in a case of intravascular large B-cell lymphoma, cutaneous variant.

J Cutan Pathol 2019 Feb 18. Epub 2019 Feb 18.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.

Intravascular large B-cell lymphoma (IVLBCL) is one of the rarest B-cell non Hodgkin lymphomas (NHL), with an aggressive clinical behavior and a poor prognosis; in fact, its treatment is still an unmet clinical need, with a 3-year overall survival (OS) rate of 60-81%, and a central nervous system relapse rate of 25%. It usually presents as a widespread disease at diagnosis with multi-organ involvement. Previously considered as a diffuse large B-cell lymphoma variant, it now represents a different extranodal large B-cell lymphoma entity in the last WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Read More

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http://dx.doi.org/10.1111/cup.13446DOI Listing
February 2019

Correlations of mouse lymphoma xenografts with the expressions of MMP-9 and Bcl-2.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1176-1183

Department of Hematology, Qingdao Center Hospital, Qingdao, Shandong, P.R. China.

Objective: To establish a mouse lymphoma xenograft model so as to investigate the correlation between the expression of matrix metallopeptidase-9 (MMP-9) and that of B-cell lymphoma 2 (Bcl-2) in lymphomas.

Materials And Methods: Diffuse large Bcl (DLBCL) cells were cultured, and a mouse lymphoma xenograft model was established via the subcutaneous injection. Mouse lymphoma tissues were extracted, and the expressions of MMP-9 and Bcl-2 messenger ribonucleic acids (mRNAs) in the xenograft tumor were detected using Real-time polymerase chain reaction (PCR). Read More

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http://www.europeanreview.org/article/17010
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http://dx.doi.org/10.26355/eurrev_201902_17010DOI Listing
February 2019
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Phosphoproteomic Analysis of Signaling Pathways in Lymphomas.

Methods Mol Biol 2019 ;1956:371-381

Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany.

Cell fate decisions are controlled by complex signal transduction processes that transmit information via posttranslational protein modifications such as phosphorylation. In lymphoma, as in other cancer types, these signaling networks are often dysregulated and thus contribute to malignant transformation and tumor maintenance. For example, B-cell antigen receptor signals are rewired in certain lymphoma types, such as diffuse large B-cell lymphomas, to promote cell growth and survival of the malignant cell clones. Read More

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http://link.springer.com/10.1007/978-1-4939-9151-8_19
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http://dx.doi.org/10.1007/978-1-4939-9151-8_19DOI Listing
January 2019
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RNA Sequencing in B-Cell Lymphomas.

Methods Mol Biol 2019 ;1956:283-303

Institute of Pathology, University Hospital Giessen, Justus-Liebig-University Giessen, Giessen, Germany.

High-throughput mRNA sequencing (RNA-Seq) provides both qualitative and quantitative evaluation of the transcriptome. This method uses complementary DNA (cDNA) to generate several millions of short sequence reads that are aligned to a reference genome allowing the comprehensive characterization of the transcripts in a cell. RNA-Seq has a wide variety of applications which lead to a pervasive adoption of this method well beyond the genomics community and a deployment of this technique as a standard part of the toolkit applied in life sciences. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_13DOI Listing
January 2019

NGS-Based High-Throughput Screen to Identify MicroRNAs Regulating Growth of B-Cell Lymphoma.

Methods Mol Biol 2019 ;1956:269-282

Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

MicroRNAs (miRNAs) play important roles in development, differentiation, and homeostasis by regulating protein translation. In B-cell lymphoma, many miRNAs have altered expression levels, and for a limited subset of them, experimental data supports their functional relevance in lymphoma pathogenesis. This chapter describes an unbiased next-generation sequencing (NGS)-based high-throughput screening approach to identify miRNAs that are involved in the control of cell growth. Read More

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http://link.springer.com/10.1007/978-1-4939-9151-8_12
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http://dx.doi.org/10.1007/978-1-4939-9151-8_12DOI Listing
January 2019
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MRD Detection in B-Cell Non-Hodgkin Lymphomas Using Ig Gene Rearrangements and Chromosomal Translocations as Targets for Real-Time Quantitative PCR.

Methods Mol Biol 2019 ;1956:199-228

Second Medical Department, University Hospital Schleswig-Holstein, Kiel, Germany.

Minimal residual disease (MRD) diagnostics is of high clinical relevance in patients with indolent B-cell non-Hodgkin lymphomas (B-NHL) and serves as a surrogate parameter to evaluate treatment effectiveness and long-term prognosis. MRD diagnostics performed by real-time quantitative PCR (RQ-PCR) is still the gold standard and currently the most sensitive and the most broadly applied method in follicular lymphoma (FL) and mantle cell lymphoma (MCL). Alternatively, droplet digital PCR (ddPCR) can be used for MRD monitoring in multiple myeloma, mantle cell lymphoma, and follicular lymphoma with comparable sensitivity, accuracy, and reproducibility. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_9DOI Listing
January 2019

Flow Cytometric MRD Detection in Selected Mature B-Cell Malignancies.

Methods Mol Biol 2019 ;1956:157-197

Division of Internal Medicine, Medical Clinic III-Hematology, Oncology and Palliative Medicine, Rostock University Medical Center, Rostock, Germany.

The quantification of submicroscopic minimal residual disease (MRD) after therapy proved to have independent prognostic significance in many mature B-cell malignancies. With the advent of routine benchtop cytometers capable of simultaneously analyzing ≥4 colors and with improved standardization, flow cytometry has become the method of choice for MRD assessments in some lymphoma entities. Herein we describe general aspects of flow cytometric standardization. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_8DOI Listing
January 2019

Stereotyped B Cell Receptor Immunoglobulins in B Cell Lymphomas.

Methods Mol Biol 2019 ;1956:139-155

Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.

Comprehensive analysis of the clonotypic B cell receptor immunoglobulin (BcR IG) gene rearrangement sequences in patients with mature B cell neoplasms has led to the identification of significant repertoire restrictions, culminating in the discovery of subsets of patients expressing highly similar, stereotyped BcR IG. This finding strongly supports selection by common epitopes or classes of structurally similar epitopes in the ontogeny of these tumors. BcR IG stereotypy was initially described in chronic lymphocytic leukemia (CLL), where the stereotyped fraction of the disease accounts for a remarkable one-third of patients. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_7DOI Listing
January 2019

Expression Cloning of Antibodies from Single Human B Cells.

Methods Mol Biol 2019 ;1956:105-125

Division of B-Cell Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

The majority of lymphomas originate from B cells at the germinal center stage. Preferential selection of B-cell clones by a limited set of antigens has been suggested to drive lymphoma development. While recent studies in chronic lymphocytic leukemia have shown that self-reactive B-cell receptors (BCR) can generate cell-autonomous signaling and proliferation, our knowledge about the role of BCRs for the development or survival of other lymphomas remains limited. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_5DOI Listing
January 2019

Laser-Based Microdissection of Single Cells from Tissue Sections and PCR Analysis of Rearranged Immunoglobulin Genes from Isolated Normal and Malignant Human B Cells.

Methods Mol Biol 2019 ;1956:61-75

Senckenberg Institute of Pathology, University of Frankfurt, Frankfurt am Main, Germany.

Normal and malignant B cells carry rearranged immunoglobulin (Ig) variable region genes, which due to their practically limitless diversity represent ideal clonal markers for these cells. We describe here an approach to isolate single cells from frozen tissue sections by microdissection using a laser-based method. From the isolated cells, rearranged IgH and Igκ genes are amplified in a semi-nested PCR approach, using a collection of V gene subgroup-specific primers recognizing nearly all V genes together with primers for the J genes. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_3DOI Listing
January 2019

Flow Cytometry for Non-Hodgkin and Hodgkin Lymphomas.

Methods Mol Biol 2019 ;1956:35-60

Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA, USA.

Multiparametric flow cytometry is a powerful diagnostic tool that permits rapid assessment of cellular antigen expression to quickly provide immunophenotypic information suitable for disease classification. This chapter describes a general approach for the identification of abnormal lymphoid populations by flow cytometry, including B, T, NK, and Hodgkin lymphoma cells suitable for the clinical and research environment. Knowledge of the common patterns of antigen expression of normal lymphoid cells is critical to permit identification of abnormal populations at disease presentation and for minimal residual disease assessment. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_2DOI Listing
January 2019

Origin and Pathogenesis of B Cell Lymphomas.

Methods Mol Biol 2019 ;1956:1-33

Institute of Cell Biology (Cancer Research), Medical School, University of Duisburg-Essen, Nordrhein-Westfalen, Essen, Germany.

Immunoglobulin (IG) gene remodeling by V(D)J recombination plays a central role in the generation of normal B cells, and somatic hypermutation and class switching of IG genes are key processes during antigen-driven B cell differentiation. However, errors of these processes are involved in the development of B cell lymphomas. IG locus-associated translocations of proto-oncogenes are a hallmark of many B cell malignancies. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_1DOI Listing
January 2019

Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis.

Front Neurosci 2019 4;13:44. Epub 2019 Feb 4.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Department of Pathology, Basic Medicine, Medical College, Xiamen University, Xiamen, China.

There are numerous types of pathological changes in human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND), including apoptosis of neurons. HIV-1 transactivator of transcription (Tat) protein, which is encoded by HIV-1, may promote apoptosis in HAND. Forkhead box O3 (FOXO3) is a multispecific transcription factor that has roles in many biological processes, including cellular apoptosis. Read More

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http://dx.doi.org/10.3389/fnins.2019.00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369160PMC
February 2019

Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2.

J Enzyme Inhib Med Chem 2019 Dec;34(1):692-702

a Lombardi Comprehensive Cancer Center, Department of Oncology , Georgetown University , Washington , DC, USA.

Matriptase is ectopically expressed in neoplastic B-cells, in which matriptase activity is enhanced by negligible expression of its endogenous inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1. HAI-1, however, is also involved in matriptase synthesis and intracellular trafficking. The lack of HAI-1 indicates that other related inhibitor, such as HAI-2, might be expressed. Read More

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http://dx.doi.org/10.1080/14756366.2019.1577831DOI Listing
December 2019

Combination of Enzastaurin and Ibrutinib synergistically induces anti-tumor effects in diffuse large B cell lymphoma.

J Exp Clin Cancer Res 2019 Feb 18;38(1):86. Epub 2019 Feb 18.

Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China.

Background: Diffuse large B cell lymphoma (DLBCL) is the most common form of lymphoma. Although durable remissions can be achieved in more than half of these patients, DLBCL remains a significant clinical challenge, with approximately 30% of patients not being cured. BCR-associated kinases (SYK, BTK, and PI3K) inhibitors have exhibited encouraging pre-clinical and clinical effects, as reported by many researchers. Read More

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http://dx.doi.org/10.1186/s13046-019-1076-4DOI Listing
February 2019

[One case of diffuse large B cell lymphoma primarily presenting in sphenoid sinus].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):139-140

Department of Radiology, Henan university huaihe hospital, Kaifeng 475000, China.

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.008DOI Listing
February 2019

DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia.

Environ Int 2019 Feb 15;126:24-36. Epub 2019 Feb 15.

National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., Athens 11635, Greece. Electronic address:

Objectives: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma.

Methods: We conducted an epigenome-wide association study on 611 adults free of diagnosed disease, living in Italy and Sweden, in whom we also measured plasma concentrations of 6 PCB congeners, DDE and hexachlorobenzene.

Results: We identified 650 CpG sites whose methylation correlates strongly (FDR < 0. Read More

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http://dx.doi.org/10.1016/j.envint.2019.01.068DOI Listing
February 2019

Intravascular large B-cell lymphoma: The Great Imitator.

Autops Case Rep 2018 Oct-Dec;8(4):e2018055. Epub 2018 Nov 30.

University of Vermont Medical Center, Department of Pathology and Laboratory Medicine. Burlington, Vermont, USA.

Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma with an estimated incidence of less than one per million. Unlike other hematopoietic malignancies, lymphadenopathy and hepatosplenomegaly are uncommon, and patients typically present with nonspecific symptoms. IVLBCL presents a diagnostic challenge and patients are usually diagnosed late in the disease course, if at all, and the prognosis is poor. Read More

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http://dx.doi.org/10.4322/acr.2018.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360824PMC
November 2018