80,392 results match your criteria Lymphoma B-Cell


The immunoreaction and antioxidant capacity of juvenile blunt snout bream (Megalobrama amblycephala) involves the PI3K/Akt/Nrf2 and NF-κB signal pathways in response to dietary methionine levels.

Fish Shellfish Immunol 2020 Jul 4. Epub 2020 Jul 4.

Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China.

A 75-day rearing trail was designed to evaluate the immunoreaction and antioxidant capacity of juvenile blunt snout bream in response to dietary methionine levels. Three practical diets were extruded to feed juveniles with graded methionine levels (0.40%, 0. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.07.005DOI Listing

Can FDG-PET replace biopsy for the evaluation of residual tumor in pediatric mature B-cell non-Hodgkin lymphoma?

Pediatr Blood Cancer 2020 Jul 7:e28310. Epub 2020 Jul 7.

Department of Clinical Research, Children Cancer Hospital Egypt, Cairo, Egypt.

Introduction: The aim of our study is to evaluate the role of F-labeled fluorodeoxy glucose positron emission tomography ( FDG-PET) scan for the detection of viable residual mass in pediatric mature B-cell non-Hodgkin lymphoma (NHL). This study also aims to detect the negative predictive value, positive predictive value (PPV), sensitivity, and specificity of FDG-PET.

Patients And Methods: A retrospective, cross-sectional nonrandomized study was carried out. Read More

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http://dx.doi.org/10.1002/pbc.28310DOI Listing

Serum interleukin-10 as a valuable biomarker for early diagnosis and therapeutic monitoring in intravascular large B-cell lymphoma.

Clin Transl Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1002/ctm2.131DOI Listing

Challenges of HIV Lymphoma Clinical Trials in Africa: Lessons From the AIDS Malignancy Consortium 068 Study.

JCO Glob Oncol 2020 Jul;6:1034-1040

AIDS Malignancy Consortium, New York, NY.

The purpose of this article is to describe lessons from the first lymphoma clinical trial conducted by the AIDS Malignancy Consortium (AMC) in sub-Saharan Africa (SSA). AMC-068 was a randomized phase II comparison of intravenous versus oral chemotherapy for HIV-positive diffuse large B-cell lymphoma. Opening in 2016, AMC-068 planned to enroll 90 patients (45 per arm) in Kenya, Malawi, Uganda, and Zimbabwe over 24 months and follow patients for 24 months to assess overall survival. Read More

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http://dx.doi.org/10.1200/GO.20.00152DOI Listing

Efficacy and safety of two pegfilgrastim biosimilars: Tripegfilgrastim and pegteograstim.

Cancer Med 2020 Jul 7. Epub 2020 Jul 7.

Division of Hematology-Oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.

Our aim was to compare the efficacy and safety of two recently developed biosimilars of pegfilgrastim, a pegylated form of the recombinant human granulocyte-colony stimulating factor (G-CSF) analog filgrastim with those of the reference pegfilgrastim. We retrospectively analyzed data from patients diagnosed with diffuse large B-cell lymphoma (DLBCL) who were treated with first-line R-CHOP chemotherapy and received pegylated G-CSF for primary prophylaxis. The following pegylated G-CSFs were analyzed in this study: reference pegfilgrastim (Neulasta ) and two of its biosimilars (tripegfilgrastim; Dulastin and pegteograstim; Neulapeg ). Read More

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http://dx.doi.org/10.1002/cam4.3261DOI Listing

MiR-200c inhibits proliferation and promotes apoptosis of Wilms tumor cells by regulating akt signaling pathway.

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6623-6631

Department of Pediatrics, Shan County Central Hospital of Heze City, Heze, China.

Objective: The aim of this study was to explore the effect of micro ribonucleic acid (miR)-200c on the proliferation and apoptosis of Wilms tumor cells, and to further elucidate its potential mechanisms.

Patients And Methods: Reverse Transcription-Polymerase Chain Reaction (RT-PCR) was used to detect the expression level of miR-200c in cancer tissues and adjacent normal tissues of 20 patients with Wilms tumor. Human primary Wilms tumor cells were taken as research objects, and were divided into Control group and miR-200c mimic group. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21648DOI Listing

MiR-204 inhibits inflammation and cell apoptosis in retinopathy rats with diabetic retinopathy by regulating Bcl-2 and SIRT1 expressions.

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6486-6493

Department of Ophthalmology, Liaoning University of Traditional Chinese Medicine, Shenyang, China.

Objective: To explore the influences of micro ribonucleic acid (miR)-204 on the rats with diabetic retinopathy by regulating the expressions of B-cell lymphoma 2 (Bcl-2) and sirtuin 1 (SIRT1).

Materials And Methods: A total of 36 Sprague-Dawley rats were randomly assigned into normal group (n=12), model group (n=12), and miR-204 mimics group (n=12). No treatment was performed in the normal group, the diabetic retinopathy model was established in model group, and miR-204 mimics were administered for intervention after modeling in the inhibitor group. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21631DOI Listing

miR-146a alleviates the apoptosis of hippocampal neurons induced by microglia activation via targeting TRAF6.

Hum Exp Toxicol 2020 Jul 7:960327120930069. Epub 2020 Jul 7.

Department of Psychiatry, Binzhou People's Hospital, Binzhou, China.

Objective: To identify the role of miR-146a and tumor necrosis factor receptor-associated factor 6 (TRAF6) for improving the apoptosis of hippocampal neurons induced by microglia activation.

Methods: Mouse microglial cell line (BV2 cell) was employed and treated with lipopolysaccharide. Mouse hippocampal nerve cell line (HT22 cell) was then grown in BV2 conditioned medium, and miR-146a overexpression and silencing cell lines were constructed. Read More

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http://dx.doi.org/10.1177/0960327120930069DOI Listing

High Incidence of Antiphospholipid Antibodies in Newly Diagnosed Patients With Lymphoma and a Proposed aPL Predictive Score.

Clin Appl Thromb Hemost 2020 Jan-Dec;26:1076029620928392

Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Given that the presence of antiphospholipid (aPL) antibodies has been proposed to be associated with thrombosis in newly diagnosed patients with lymphoma, we conducted a prospective cohort study on these patients. In all, 154 patients were enrolled. More than half were advanced-stage diffuse large B-cell lymphoma. Read More

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http://dx.doi.org/10.1177/1076029620928392DOI Listing

Optimized high-fidelity 3DPCR to assess potential mitochondrial targeting by activation-induced cytidine deaminase.

FEBS Open Bio 2020 Jul 6. Epub 2020 Jul 6.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Research Center of Stomatology, Xi'an Jiaotong University College of Stomatology, Xi'an, Shaanxi, P. R. China.

Activation induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination of immunoglobulin genes in B cells while off-targeted AID activity contributes to oncogenic mutations and chromosomal translocations associated with B cell malignancies. Paradoxically, only a minority of AID is allowed to access the nuclear genome but the majority of AID is retained in the cytoplasm. It is unknown whether cytoplasmic AID can access and target the mitochondrial genome (mtDNA). Read More

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http://dx.doi.org/10.1002/2211-5463.12927DOI Listing

Adverse prognostic impact of regulatory T-cells in testicular diffuse large B-cell lymphoma.

Eur J Haematol 2020 Jul 6. Epub 2020 Jul 6.

Research Program Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Objectives: Testicular diffuse large B-cell lymphoma (T-DLBCL) is a rare and aggressive extranodal lymphoma. We have previously shown that high content of tumor-infiltrating lymphocytes (TILs) and PD-1 expressing TILs associate with better survival in T-DLBCL. In this study, we have further characterized distinct TIL subtypes and their proportions in association with patient demographics and survival. Read More

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http://dx.doi.org/10.1111/ejh.13484DOI Listing

A Clinicopathological Approach to Odontogenic Cysts: the Role of Cytokeratin 17 and bcl2 Immunohistochemistry in Identifying Odontogenic Keratocysts.

Pathol Oncol Res 2020 Jul 6. Epub 2020 Jul 6.

Department of Pathology, University of Szeged, Állomás u. 1, Szeged, H-6725, Hungary.

Odontogenic keratocysts (OKCs) are developmental cysts of the jaws that require proper diagnosis due to their potential for local aggressive growth and recurrences. OKCs have a typical parakeratotic epithelium demonstrating transepithelial cytokeratin 17 (CK17) and basal bcl2 staining on immunohistochemistry (IHC), which distinguishes them from other common jaw cysts. Secondary to inflammation, the epithelial lining may be altered and loses the typical IHC phenotype. Read More

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http://dx.doi.org/10.1007/s12253-020-00866-4DOI Listing

Ga-NOTA-FAPI-04 PET/CT in a patient with primary gastric diffuse large B cell lymphoma: comparisons with [F] FDG PET/CT.

Eur J Nucl Med Mol Imaging 2020 Jul 6. Epub 2020 Jul 6.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian, Beijing, 100142, China.

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http://dx.doi.org/10.1007/s00259-020-04946-0DOI Listing

YL064 activates proteasomal-dependent degradation of c-Myc and synergistically enhances the anti-tumor activity of ABT-199 in diffuse large B cell lymphoma.

Signal Transduct Target Ther 2020 Jul 6;5(1):116. Epub 2020 Jul 6.

Hongqiao International Institute of Medicine, Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

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http://dx.doi.org/10.1038/s41392-020-00236-1DOI Listing

TIGIT expression is associated with T-cell suppression and exhaustion and predicts clinical outcome and anti-PD-1 response in follicular lymphoma.

Clin Cancer Res 2020 Jul 6. Epub 2020 Jul 6.

Division of Hematology, Mayo Clinic.

Purpose: T cell Ig and ITIM domain (TIGIT), a member of the immune checkpoint family, is important in normal T-cell biology. However, the phenotypical profile and clinical relevance of TIGIT in follicular lymphoma (FL) is largely unknown.

Experimental Design: Biopsy specimens from a cohort of 82 FL patients were analyzed using mass cytometry (CyTOF) to explore the phenotype and biological and clinical significance of TIGIT+ T cells. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-20-0558DOI Listing

Follicular dendritic cell tumor in the context of a Castleman disease in a patient with Diffuse Large B Cell Lymphoma: Diagnosis and follow-up with F-FDG PET/CT.

Rev Esp Med Nucl Imagen Mol 2020 Jul 3. Epub 2020 Jul 3.

Servei Medicina Nuclear-IDI Girona. Hospital Universitari de Girona Dr. Josep Trueta, Catalunya, España.

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http://dx.doi.org/10.1016/j.remn.2020.06.011DOI Listing

Immunoglobulin M Paraproteinaemias.

Cancers (Basel) 2020 Jun 25;12(6). Epub 2020 Jun 25.

Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore 119228, Singapore.

Monoclonal paraproteinaemia is an increasingly common reason for referral to haematology services. Paraproteinaemias may be associated with life-threatening haematologic malignancies but can also be an incidental finding requiring only observation. Immunoglobulin M (IgM) paraproteinaemias comprise 15-20% of monoclonal proteins but pose unique clinical challenges. Read More

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http://dx.doi.org/10.3390/cancers12061688DOI Listing

Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections.

PLoS One 2020 6;15(7):e0235328. Epub 2020 Jul 6.

Department of Pediatrics, Indiana University, Indianapolis, Indiana, United States of America.

Objective: Current urinary tract infection (UTI) diagnostic strategies that rely on leukocyte esterase have limited accuracy. We performed an aptamer-based proteomics pilot study to identify urine protein levels that could differentiate a culture proven UTI from culture negative samples, regardless of pyuria status.

Methods: We analyzed urine from 16 children with UTIs, 8 children with culture negative pyuria and 8 children with negative urine culture and no pyuria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235328PLOS

Clonal hematopoiesis in patients with high-grade B-cell lymphoma is associated with inferior outcome.

Am J Hematol 2020 Jul 6. Epub 2020 Jul 6.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1002/ajh.25927DOI Listing

Prognostic significance of histologic grade and Ki-67 proliferation index in follicular lymphoma.

Hematol Oncol 2020 Jul 6. Epub 2020 Jul 6.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.

The prognostic value of histologic grading and the Ki-67 proliferation index in follicular lymphoma (FL) is controversial. This study investigated the clinical usefulness of these two factors in Asian FL patients. Four hundred and thirty-three patients diagnosed with FL were retrospectively reviewed with a median follow-up time of 47. Read More

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http://dx.doi.org/10.1002/hon.2778DOI Listing

Recent malignant testicular tumor trend in Japan, a country with an aging population: a large-scale study of 2012-2015 hospital-based cancer registry data.

Jpn J Clin Oncol 2020 Jul 6. Epub 2020 Jul 6.

Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Objective: Japan's national database of hospital-based cancer registries is estimated to cover ~67% of all new cancer cases. Using this database, we analyzed the characteristics of the recently diagnosed testicular malignancy.

Methods: We obtained data for 6510 adult testicular malignancy patients diagnosed in 2012-2015. Read More

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http://dx.doi.org/10.1093/jjco/hyaa110DOI Listing

Neurolymphomatosis, a rare manifestation of peripheral nerve involvement in lymphomas: suggestive features and diagnostic challenges.

J Peripher Nerv Syst 2020 Jul 5. Epub 2020 Jul 5.

Neurology Unit, Department of Neuroscience, University of Padova, Padova, Italy.

Background: Neurolymphomatosis, the infiltration of the peripheral nervous system from lymphoid cells, represents an uncommon manifestation of lymphomas. We describe the challenging diagnostic work-up in a patient with neurolymphomatosis.

Case Report: a 58-yr-old woman with previous breast diffuse large B-cell lymphoma (DLBCL) treated with chemo- and radiation-therapy, presented with dysesthesias, neuropathic pain at left abdomen and thigh, and weakness at left lower limb 9 years after disease remission. Read More

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http://dx.doi.org/10.1111/jns.12401DOI Listing

Cantharidin-induced acute hepatotoxicity: the role of TNF-α, IKK-α, Bcl-2, Bax and caspase3.

J Appl Toxicol 2020 Jul 5. Epub 2020 Jul 5.

Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cantharidin is of high medicinal value but has strong toxicity. Nowadays, multiple research has focused on the mechanism of its antitumor activity while research on toxicological profiles associated with cantharidin poisoning is still limited. Its hepatotoxicity has attracted attention recently for the crucial role of the liver in detoxification. Read More

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http://dx.doi.org/10.1002/jat.4003DOI Listing

Primary central nervous system lymphomas associated with chronic inflammation: diagnostic pitfalls of central nervous system lymphomas.

Brain Tumor Pathol 2020 Jul 5. Epub 2020 Jul 5.

Department of Pathology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.

In recent years, the features of lymphomas associated with chronic inflammation, referred to as diffuse large B-cell lymphoma (DLBCL) associated with chronic inflammation (DLBCL-CI), have been elucidated. DLBCL-CI is an aggressive lymphoma occurring in the context of long-standing chronic inflammation and showing an association with Epstein-Barr virus. Fibrin-associated diffuse large B-cell lymphoma (F-DLBCL) was suggested as a new and unusual form of DLBCL-CI in the most recent version of the World Health Organization classification. Read More

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http://dx.doi.org/10.1007/s10014-020-00373-zDOI Listing

BCL11A Is Oncogenic and Predicts Poor Outcomes in Natural Killer/T-Cell Lymphoma.

Front Pharmacol 2020 4;11:820. Epub 2020 Jun 4.

Department of Hematological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

The current treatment for natural killer/T-cell lymphoma (NKTL) among advanced/relapsed patients is unsatisfying, thereby highlighting the need for novel therapeutic targets. B-cell chronic lymphocytic leukemia/lymphoma 11 A (BCL11A), as a transcription factor, is oncogenic in several neoplasms. However, its function in NKTL remains unclear. Read More

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http://dx.doi.org/10.3389/fphar.2020.00820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311857PMC

Cladribine Induces ATF4 Mediated Apoptosis and Synergizes with SAHA in Diffuse Large B-Cell Lymphoma Cells.

Int J Med Sci 2020 30;17(10):1375-1384. Epub 2020 May 30.

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Cladribine is a purine nucleoside analog used to treat B-cell chronic lymphocytic leukemia and hairy cell leukemia, also functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. The therapeutic role of cladribine against diffuse large B-cell lymphoma cells (DLBCL) is still undefined. In the present study, we demonstrated that cladribine inhibited cell proliferation and induced G phase arrest in human DLBCL cells. Read More

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http://dx.doi.org/10.7150/ijms.41793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330656PMC

Differential Localization and Invasion of Tumor Cells in Mouse Models of Human and Murine Leukemias.

Acta Histochem Cytochem 2020 Jun 29;53(3):43-53. Epub 2020 Apr 29.

Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.

Leukemias are refractory hematopoietic malignancies, for which the development of new therapeutic agents requires studies using tumor-bearing mouse models. Although several organs are commonly examined in such studies to evaluate the disease course, the effectiveness of interventions and the localization of tumor cells in the affected organs are still unclear. In this study, we histologically examined the distribution of leukemia cells in several organs using two leukemic mouse models produced by the administration of two cell lines (THP-1, a human myelomonocytic leukemia, and A20, a mouse B cell leukemia/lymphoma) to severe immunodeficient mice. Read More

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http://dx.doi.org/10.1267/ahc.19035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322163PMC

[Bendamustine and rituximab combination therapy for recurrent indolent B-cell lymphomas: a retrospective single-institution study].

Rinsho Ketsueki 2020 ;61(6):598-604

Division of Hematology, National Defense Medical College Hospital.

This retrospective study evaluated the outcomes of patients treated with combination of bendamustine and rituximab (BR) for recurrent indolent B-cell lymphoma from January 2011 to February 2018 in our department. The cohort included 36 males and 27 females, and majority of the patients (59%) were between 51 and 70 years of age. The disease types were follicular lymphoma (FL) and mantle-cell lymphoma in 42 (67%) and 15 (24%) patients, respectively. Read More

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http://dx.doi.org/10.11406/rinketsu.61.598DOI Listing
January 2020

The BCL-2 family protein inhibitor ABT-737 as an additional tool for the treatment of EBV-associated post-transplant lymphoproliferative disorders.

Mol Oncol 2020 Jul 4. Epub 2020 Jul 4.

UMR 8126, CNRS, Université Paris-Saclay, Institut Gustave Roussy, 94805, Villejuif, France.

Post-transplant lymphoproliferative disorders (PTLD) and Burkitt lymphoma (BL) are B-cell malignancies strongly associated with Epstein-Barr virus (EBV) infection. In these lymphoproliferative disorders, EBV infection induces an increase in the expression of the anti-apoptotic protein BCL-2. Given its chemoprotective effect, BCL-2 constitutes an attractive target for new therapeutic strategies for EBV-positive B-cell malignancies. Read More

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http://dx.doi.org/10.1002/1878-0261.12759DOI Listing

A case of primary cutaneous B-cell lymphoma with immature features in an old man. Diffuse Large B-cell Lymhpoma with immature features or B-cell Lymhpoblastic Lymphoma?

J Cutan Pathol 2020 Jul 4. Epub 2020 Jul 4.

Oncology and Hematology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Primary cutaneous B-cell lymphomas are a heterogeneous group of lymphoid neoplasms primarily occurring in the skin. Although most cases are represented by primary cutaneous follicle center cell lymphoma, primary cutaneous marginal zone lymphoma and leg-type diffuse large B-cell lymphoma, other diffuse large B-cell lymphomas and B-cell lymphoblastic lymphoma may rarely present primarily in the skin. In this setting, the presence of histopathologic and immunohistochemical features of cellular immaturity is exceedingly rare and may represent a diagnostic challenge. Read More

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http://dx.doi.org/10.1111/cup.13795DOI Listing

Association of genetic polymorphism of BCL-2 (rs2279115) with susceptibility to HCV-related hepatocellular carcinoma.

Immunol Res 2020 Jul 4. Epub 2020 Jul 4.

Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Hepatitis C virus (HCV) infection is the main risk factor for chronic hepatitis (CHC), liver cirrhosis, and hepatocellular carcinoma (HCC). B cell lymphoma-2 (BCL-2) prevents apoptosis, and its overexpression could promote cancer cell survival. The purpose of this study is to evaluate the association of Bcl-2 gene polymorphism (rs2279115) and HCV-related HCC susceptibility. Read More

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http://dx.doi.org/10.1007/s12026-020-09143-7DOI Listing

Hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish following sub-chronic exposure to BDE-47 and BDE-153.

Environ Toxicol 2020 Jul 4. Epub 2020 Jul 4.

Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, China.

Polybrominated diphenyl ethers (PBDEs) are ubiquitous and prolific contaminant in both the abiotic and biotic environment because of the wide industrial applications of these chemicals. In the present study, the effects of 2,2',4,4'-tetrabrominateddiphenyl ether (BDE-47) and 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153) exposure on the induction of hepatic oxidative stress, DNA damage, and the expression of apoptosis-related genes in adult zebrafish were investigated. The activities of antioxidant enzymes, such as catalase and superoxide dimutase, significantly increased when adult zebrafish was exposed to various concentrations of BDE-47 and BDE-153 for 7 and 15 days. Read More

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http://dx.doi.org/10.1002/tox.22985DOI Listing

FDG-PET/CT after two cycles of R-CHOP in DLBCL predicts complete remission but has limited value in identifying patients with poor outcome - final result of a UK National Cancer Research Institute prospective study.

Br J Haematol 2020 Jul 4. Epub 2020 Jul 4.

King's College London and Guy's and St Thomas' PET Centre, School of Biomedical Engineering and Imaging Sciences, King's College London, King's Health Partners, London, UK.

The UK National Cancer Research Institute initiated a prospective study (UKCRN-ID 1760) to assess the prognostic value of early fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in diffuse large B-cell lymphoma (DLBCL). In total, 189 patients with DLBCL treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) had baseline and post-cycle-2 PET (PET2) within a quality assurance framework. Treatment decisions were based on CT; PET2 was archived for central blinded reporting after treatment completion. Read More

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http://dx.doi.org/10.1111/bjh.16875DOI Listing

Diffuse large B-cell lymphoma in right atrium.

Eur Heart J 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiovascular Surgery, West China Hospital, Sichuan University, No. 37 GuoXue Xiang, Chengdu, Sichuan 610041, People's Republic of China.

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http://dx.doi.org/10.1093/eurheartj/ehaa516DOI Listing

Evolving insights into the genomic complexity and immune landscape of diffuse large B-cell lymphoma: opportunities for novel biomarkers.

Mod Pathol 2020 Jul 3. Epub 2020 Jul 3.

Department of Hematopathology, Division of Pathology and Laboratory Medicine, MD Anderson Cancer Center, Houston, TX, USA.

Recently, comprehensive genomic analyses have allowed a better molecular characterization of diffuse large B-cell lymphoma (DLBCL), offering novel opportunities in patient risk stratification and management. In the era of precision medicine, this has allowed us to move closer toward a more promising therapeutic outcome in the setting of DLBCL. In this review, we highlight the newly reported heterogeneous mutational landscapes of DLBCL (from two whole-exome sequencing studies, and from a more recent work targeting a 293-gene of a hematologic malignancy-designed panel. Read More

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http://dx.doi.org/10.1038/s41379-020-0616-yDOI Listing

Anti-tumor Properties of Extracts in H-Ras Liver Cancer Are Mediated Through ROS-dependent Mitochondrial Dysfunction.

Anticancer Res 2020 Jul;40(7):3819-3830

College of Life Science & Biotechnology, Heilongjiang Bayi Agricultural University, Daqing, P.R. China

Background: Picrasma quassioides (PQ) is a traditional Asian herbal medicine with anti-tumor properties that can inhibit the viability of HepG2 liver cancer cells. H-Ras is often mutated in liver cancer, however, the effect of PQ treatment on H-Ras mutated liver cancer is unclear. This study aimed to investigate the role of PQ on ROS accumulation and mitochondrial dysfunction in H-ras mutated HepG2 (HepG2) cells. Read More

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http://dx.doi.org/10.21873/anticanres.14371DOI Listing

Pan- and Isoform-specific Inhibition of the Bromodomain and Extra-terminal Proteins and Evaluation of Synergistic Potential With Entospletinib in Canine Lymphoma.

Anticancer Res 2020 Jul;40(7):3781-3792

Department of Medicine, Clinic III, Hematology, Oncology and Palliative Medicine, University Medical Center Rostock, Rostock, Germany

Background/aim: Canine B-cell lymphoma represents a useful in vivo model for human diffuse large B-cell lymphoma (DLBCL). Pan-Bromodomain and extra-terminal (BET) inhibition targeting BRD2/3/4 and selective inhibition of BRD4, as well as spleen tyrosine kinase (SYK) inhibition, are currently evaluated as haematologic cancer therapy. Herein, we characterized the differences in the biologic response of isoform-specific or pan-BET inhibition alone or in combination with SYK inhibition. Read More

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http://dx.doi.org/10.21873/anticanres.14367DOI Listing

Diagnosis of Intracranial Primary Central Nervous System Lymphoma Based on Magnetic Resonance Imaging.

Neurosci Lett 2020 Jun 30:135225. Epub 2020 Jun 30.

Department of Radiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. Electronic address:

Objective: To analyse the traditional MRI signs, diffusion weighted imaging (DWI), perfusion weighted imaging (PWI), and hydrogen proton magnetic resonance spectroscopy (1H-MRS) of intracranial primary central nervous system lymphoma in immunocompetent people. To explore its diagnostic value.

Methods: The paper retrospectively analysed the MRI signs of 12 patients with primary central nervous system lymphoma confirmed by surgery and pathology. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135225DOI Listing

TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate.

Cell 2020 Jul 2. Epub 2020 Jul 2.

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA. Electronic address:

The most aggressive B cell lymphomas frequently manifest extranodal distribution and carry somatic mutations in the poorly characterized gene TBL1XR1. Here, we show that TBL1XR1 mutations skew the humoral immune response toward generating abnormal immature memory B cells (MB), while impairing plasma cell differentiation. At the molecular level, TBL1XR1 mutants co-opt SMRT/HDAC3 repressor complexes toward binding the MB cell transcription factor (TF) BACH2 at the expense of the germinal center (GC) TF BCL6, leading to pre-memory transcriptional reprogramming and cell-fate bias. Read More

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http://dx.doi.org/10.1016/j.cell.2020.05.049DOI Listing

Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola).

Transbound Emerg Dis 2020 Jul 3. Epub 2020 Jul 3.

Group of Epidemiology and Environmental Health, Animal Health Research Center (INIA-CISA).Valdeolmos, Madrid, 28130, Spain.

The European mink (Mustela lutreola) is a riparian mustelid, considered one of the most endangered carnivores in the world. Alpha, beta, and gammaherpesviruses described in mustelids have been occasionally associated with different pathological processes. However, there is no information about the herpesviruses species infecting European minks. Read More

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http://dx.doi.org/10.1111/tbed.13713DOI Listing

Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.

Leuk Lymphoma 2020 Jul 3:1-9. Epub 2020 Jul 3.

Comprehensive Cancer Center Mainfranken, Uniklinikum Würzburg, Würzburg, Germany.

Minimal residual disease (MRD) is the strongest predictor of relapse in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In BLAST study (NCT01207388), adults with BCP-ALL in remission with MRD after chemotherapy received blinatumomab, a CD19 BiTE immuno-oncotherapy, 15 µg/m/day for up to four 6-week cycles (4 weeks continuous infusion, 2 weeks off). Survival was evaluated for 110 patients, including 74 who received HSCT in continuous complete remission. Read More

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http://dx.doi.org/10.1080/10428194.2020.1780583DOI Listing

Silencing Stat3 inhibits viability and induces apoptosis in BGC-823 human gastric cancer cell line.

Biotech Histochem 2020 Jul 3:1-6. Epub 2020 Jul 3.

School of Life Sciences, Shanghai University , Shanghai, P.R. China.

Gastric cancer (GC) is characterized by infrequent early diagnosis, poor prognosis and high mortality. Signal transducer and activator of transcription 3 (Stat3) and signal transducer and activator of transcription 5b (Stat5b) play multiple roles in the development and progression of many human cancers. We investigated the effects of silencing Stat3 and Stat5b on the viability and apoptosis of the human gastric cancer cell line, BGC-823. Read More

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http://dx.doi.org/10.1080/10520295.2020.1770332DOI Listing

Clinical utility of target capture-based panel sequencing in hematological malignancies: a multicenter feasibility study.

Cancer Sci 2020 Jul 3. Epub 2020 Jul 3.

Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.

Although next-generation sequencing-based panel testing is well-practiced in the field of cancer medicine for the identification of target molecules in solid tumors, the clinical utility and clinical issues surrounding panel testing in hematological malignancies have yet to be fully evaluated. We conducted a multicenter prospective clinical-sequencing study to verify the feasibility of a panel test for hematological tumors, including acute myeloid leukemia, acute lymphoblastic leukemia, multiple myeloma, and diffuse large B-cell lymphoma. Out of 96 eligible patients, 79 patients (82%) showed potentially actionable findings, based on the clinical-sequencing assays. Read More

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http://dx.doi.org/10.1111/cas.14552DOI Listing

Correction to: Differential diagnosis of sinonasal extranodal NK/T cell lymphoma and diffuse large B cell lymphoma on MRI.

Neuroradiology 2020 Jul 2. Epub 2020 Jul 2.

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.

The above article was published online with incorrect Fig. 1. The correct Fig. Read More

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http://dx.doi.org/10.1007/s00234-020-02488-8DOI Listing

Ginsenoside compound-Mc1 attenuates oxidative stress and apoptosis in cardiomyocytes through an AMP-activated protein kinase-dependent mechanism.

J Ginseng Res 2020 Jul 26;44(4):664-671. Epub 2019 Aug 26.

Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.

Background: Ginsenoside compound-Mc1 (Mc1) is a member of the deglycosylated ginsenosides obtained from ginseng extract. Although several ginsenosides have a cardioprotective effect, this has not been demonstrated in ginsenoside Mc1.

Methods: We treated H9c2 cells with hydrogen peroxide (HO) and ginsenoside Mc1 to evaluate the antioxidant effects of Mc1. Read More

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http://dx.doi.org/10.1016/j.jgr.2019.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322759PMC

Anticancer Effects of ACT001 via NF-κB Suppression in Murine Triple-Negative Breast Cancer Cell Line 4T1.

Cancer Manag Res 2020 26;12:5131-5139. Epub 2020 Jun 26.

Lung Cancer Center, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.

Purpose: ACT001 is a novel sesquiterpene lactone derivative with anticancer effects, including the reversal of tamoxifen resistance in estrogen receptor-positive breast cancer cells. However, few studies have investigated the anticancer effects of ACT001 in triple-negative breast cancer (TNBC), a highly aggressive cancer with a poor prognosis. This study aimed to investigate the effects of ACT001 on TNBC and the potential mechanism underlying these effects. Read More

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http://dx.doi.org/10.2147/CMAR.S244748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326172PMC

Chronic lymphocytic leukemia: from molecular pathogenesis to novel therapeutic strategies.

Haematologica 2020 Jul 2. Epub 2020 Jul 2.

Hematopathology Section, Hospital Cllinic, University of Barcelona, Barcelona, Spain

Chronic lymphocytic leukemia is a well-defined lymphoid neoplasm with very heterogeneous biological and clinical behavior. The last decade has been remarkably fruitful in novel findings elucidating multiple aspects of the pathogenesis of the disease including mechanisms of genetic susceptibility, insights into the relevance of immunogenetic factors driving the disease, profiling of genomic alterations, epigenetic subtypes, global epigenomic tumor cell reprogramming, modulation of tumor cell and microenvironment interactions, and dynamics of clonal evolution from early steps in monoclonal B cell lymphocytosis to progression and transformation into diffuse large B-cell lymphoma. All this knowledge has offered new perspectives that are being exploited therapeutically with novel target agents and management strategies. Read More

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http://dx.doi.org/10.3324/haematol.2019.236000DOI Listing