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Sex Transm Dis 2021 Jun 1. Epub 2021 Jun 1.

Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA Association of Public Health Laboratories, Silver Spring, MD Correspondence and reprints: Ellen N. Kersh, CDC, 1600 Clifton Rd NE Mailstop H23-3; Atlanta, GA 30329; phone 404 639 2728; fax 404 639 4664.

Abstract: The frequency of lymphogranuloma venereum (LGV) or invasive Chlamydia trachomatis (CT) infection with serovar L1, L2 or L3 is unknown in the United States. While no diagnostic test is commercially available, we used a laboratory-developed test and detected LGV-associated serovar L2 in 14% of 132 remnant CT-positive rectal swabs. Read More

J Eur Acad Dermatol Venereol 2021 May 31. Epub 2021 May 31.

Department of Sexual Health and HIV, Birmingham University Hospitals NHS Foundation Trust, Birmingham, UK.

This guideline intents to offer guidance on the diagnosis and management of patients with gastrointestinal symptoms and a suspected sexually transmitted cause. Proctitis is defined as an inflammatory syndrome of the anal canal and/or the rectum. Infectious proctitis can be sexually transmitted via genital-anal mucosal contact, but some also via digital contact and toys. Read More

Rev Soc Bras Med Trop 2021 17;54(suppl 1):e2020663. Epub 2021 May 17.

Ministério da Saúde, Secretaria de Vigilância em Saúde, Brasília, DF, Brasil.

Infections that cause genital ulcers are one of the themes comprising the Clinical Protocol and Therapeutic Guidelines for Comprehensive Care for People with Sexually Transmitted Infections, published by the Brazilian Ministry of Health in 2020. The Protocol and Guidelines have been developed based on scientific evidence and validated in discussions with specialists. This article addresses clinical genital ulcer syndrome caused by sexually transmitted infections and its most common etiological agents: Treponema pallidum (syphilis), herpes simplex virus-2 (genital herpes) and herpes simplex virus-1 (perioral herpes), Haemophilus ducreyi (chancroid), Chlamydia trachomatis serotypes L1, L2 and L3 (lymphogranuloma venereum), and Klebsiella granulomatis (donovanosis). Read More

Int J STD AIDS 2021 May 13:956462420948353. Epub 2021 May 13.

Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.

We present the case of a 66-year-old bisexual patient suffering from painful bloody defecation, linked to rectal thickening, rectovesical fistula and enlarged lymph nodes in the mesorectal area. The patient was misdiagnosed with rectal cancer (T3 N2) on MRI but the symptoms of the patient were due to lymphogranuloma venereum. After adequate treatment with doxycycline, symptoms faded within days; a control MRI showed complete regression of all pathologic alterations. Read More

mBio 2021 May 11;12(3). Epub 2021 May 11.

Department of Pediatrics, University of California San Francisco, Oakland, California, USA

The obligate intracellular pathogen () is the leading cause of bacterial sexually transmitted infections and blindness globally. To date, urogenital strains are considered tryptophan prototrophs, utilizing indole for tryptophan synthesis within a closed-conformation tetramer comprised of two α (TrpA)- and two β (TrpB)-subunits. In contrast, ocular strains are auxotrophs due to mutations in TrpA, relying on host tryptophan pools for survival. Read More

Euro Surveill 2021 05;26(18)

Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

Despite social distancing measures implemented in Madrid to prevent the propagation of SARS-CoV-2, a significant increase (57.1%; 28.5 to 38. Read More

J Eur Acad Dermatol Venereol 2021 Apr 25. Epub 2021 Apr 25.

Dermatology Department, Hospital Santo António dos Capuchos, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

Background: Lymphogranuloma venereum (LGV) is a sexual transmitted infection (STI), currently endemic within the population of men who have sex with men (MSM) of Western Countries. L2B variant has been reported as the predominant strain in the current LGV epidemics, although a shift towards L2-434 has been observed in some European countries.

Objectives: To evaluate and characterize the population with LGV infection diagnosed in Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal. Read More

BMJ Case Rep 2021 Apr 14;14(4). Epub 2021 Apr 14.

Department of General Surgery, University Hospitals Plymouth NHS Trust, Plymouth, UK.

A 49-year-old man presented with a 1-week history of abdominal pain, distension, diarrhoea and fatigue. CT of the abdomen and pelvis revealed peritonitis with no identifiable cause. Diagnostic laparoscopy was performed, which excluded gastrointestinal perforation. Read More

Indian J Sex Transm Dis AIDS 2020 Jul-Dec;41(2):176-180. Epub 2020 Jul 31.

Department of Dermatology Venereology and Leprology, Government Medical College, Patiala, Punjab, India.

Background: Sexually transmitted infections (STIs) are dynamic and show a variable prevalence in different parts of the country. Moreover, the prevalence changes with time in the same geographical area. It is important to have the knowledge of current trend of STIs and partner notification (PN) rate in a particular area for the effective implementation of preventive and control measures. Read More

Biomed Res Int 2021 13;2021:8889247. Epub 2021 Mar 13.

School of Pharmacy, Nantong University, Nantong 226001, China.

The obligate intracellular bacterium is a group of worldwide human pathogens that can lead to serious reproductive problems. The frequent clinical treatment failure promoted the development of novel antichlamydial agents. Here, we firstly reported a group of pyrroloisoxazolidine-inhibited in a dose-dependent manner . Read More

Int J STD AIDS 2021 06 26;32(7):588-590. Epub 2021 Mar 26.

Faculty of Medicine, 7423University of Southampton, Southampton, UK.

The 34th IUSTI European Conference was held from the 3rd to the 5th of October 2020. There were presentations on STIs in Europe, many centred on Romania. A full session was devoted to syphilis, including global efforts in syphilis vaccine development. Read More

ANZ J Surg 2021 Feb 17. Epub 2021 Feb 17.

Department of General Surgery, Cairns Base Hospital, Cairns, Queensland, Australia.

Actas Urol Esp (Engl Ed) 2021 Apr 2;45(3):245-246. Epub 2021 Feb 2.

Servicio de Dermatología, Hospital Universitario Doctor Peset, Valencia, España.

BMJ Case Rep 2021 Feb 4;14(2). Epub 2021 Feb 4.

Division of HIV, Infectious Diseases and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.

Lymphogranuloma venereum (LGV) has been increasingly reported, and many clinicians are familiar with it as a cause of proctocolitis or inguinal adenopathy. On the other hand, LGV is less commonly considered as a cause of isolated genital ulcerative disease in comparison to other etiologies such as syphilis or herpes simplex. We report a case of persistent perianal ulcerations due to LGV in an HIV-positive patient, confirmed by nucleic acid amplification testing. Read More

Clin Infect Dis 2021 Jan 29. Epub 2021 Jan 29.

National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal.

Previously, we identified a Chlamydia trachomatis Lymphogranuloma venereum (LGV) recombinant strain possessing a unique non-LGV ompA genotype. Here, culture-independent genome sequencing confirms its circulation in Europe, Middle East and North America, and unveils genetic evidence of emergence of antibiotic resistance. Multi-country and systematic molecular surveillance is needed. Read More

Int J STD AIDS 2021 May 26;32(6):517-522. Epub 2021 Jan 26.

Department of Internal Medicine, 10215OLVG, Amsterdam, The Netherlands.

Objective: The incidence of lymphogranuloma venereum (LGV) in Europe is increasing. However, diagnosing LGV in a hospital setting is rare. We analysed the diagnostic process and clinical characteristics of patients with LGV in a hospital setting. Read More

Acta Derm Venereol 2021 Feb 16;101(2):adv00396. Epub 2021 Feb 16.

Olafia Clinic, Trondheimsveien 2, Bygg N, Oslo, Norway.

Clin Infect Dis 2021 Jan 19. Epub 2021 Jan 19.

Dermatology Department - ISGlobal. Hospital Clinic de Barcelona, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.

Background: Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by Chlamydia trachomatis (CT) serovars L1, L2, and L3 and is endemic among men who have sex with men (MSM) in Europe. We evaluated weekly oral Azithromycin 1 g for 3 weeks as a treatment for LGV proctitis.

Methods: This is an open clinical trial with convenience allocation according to treating physician preferences. Read More

Sex Transm Dis 2021 02;48(2):e15-e17

From the Foundation for Professional Development, Research Unit, East London.

Abstract: We conducted an observational study of lymphogranuloma venereum (LGV) biovar Chlamydia trachomatis infection in HIV-infected women in South Africa. The LGV biovar was detected in vaginal specimens of 17 (20%) of 85 women with C. trachomatis infection; 29% were symptomatic. Read More

Ned Tijdschr Geneeskd 2020 11 19;164. Epub 2020 Nov 19.

OLVG, afd. Interne Geneeskunde, Amsterdam.

Lymphogranuloma venereum (LGV) is an invasive sexually transmitted infection caused by Chlamydia trachomatis genotypes L1, L2 and L3. Until recently, LGV was rarely seen in developed countries. However, an outbreak of LGV infections in Europe amongst men who have sex with men (MSM) has been reported in the past decades. Read More

Pathogens 2020 Nov 30;9(12). Epub 2020 Nov 30.

Laboratory of Medical Microbiology and Infectious Diseases, Isala Clinics, 8025 AB Zwolle, The Netherlands.

A man with a well-controlled HIV infection, previously diagnosed with lymphogranuloma venereum and treated for Hodgkin's lymphoma, was suffering from chronic diarrhea. He travelled to Indonesia in the month prior to the start of complaints. Over a 15-month period, sequences related to , and were detected by 16S rRNA qPCR-based assays in various stool samples and in a colon biopsy. Read More

Front Immunol 2020 26;11:555305. Epub 2020 Oct 26.

Laboratory for Immunology and Animal Biotechnology, Department of Animal Production, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.

The current study was designed to evaluate the pathogenesis, pathology and immune response of female genital tract infection with L2c, the most recently discovered lymphogranuloma venereum strain, using a porcine model of sexually transmitted infections. Pigs were mock infected, infected once or infected and re-infected intravaginally, and samples were obtained for chlamydial culture, gross and microscopic pathology, and humoral and cell-mediated immunity. Intravaginal inoculation of pigs with this bacterium resulted in an infection that was confined to the urogenital tract, where inflammation and pathology were caused that resembled what is seen in human infection. Read More

J Clin Microbiol 2021 Jan 21;59(2). Epub 2021 Jan 21.

INSERM, Institut Cochin U1016-CNRS UMR8104, Université Sorbonne Paris Descartes, Paris, France

We evaluated the utility of the commercial Allplex genital ulcer real-time PCR multiplex assay for detecting , herpes simplex virus 1 (HSV-1) and 2 (HSV-2), and serovar L (lymphogranuloma venereum [LGV]) DNA in mucosal and genital ulcers in the context of suspected syphilis. In total, 374 documented genital and mucosal ulcers from patients with and without syphilis presenting at several sexually transmitted infection (STI) centers in France from October 2010 to December 2016 were analyzed at the National Reference Center (CNR) for Bacterial STIs at Cochin Hospital in Paris. subsp. Read More

Actas Dermosifiliogr (Engl Ed) 2021 May 27;112(5):453-457. Epub 2020 Oct 27.

Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.

The incidence of lymphogranuloma venereum (LGV) -a sexually transmitted infection (STI) produced by the L1, L2, and L3 serovars of Chlamydia trachomatis- is increasing. The 8 patients in this case series were diagnosed with LGV in the STI unit of our dermatology department. Our patients were younger than those in previously published case series, and on presentation they most often complained of tumorous masses (lymphadenopathy) in the groin. Read More

Sex Transm Infect 2020 Oct 26. Epub 2020 Oct 26.

Microbiology, DIMES, University of Bologna, Bologna, Emilia-Romagna, Italy.

Objectives: Lymphogranuloma venereum (LGV) is an STI caused by serovars L1-L3. In Europe, the current epidemic is caused mainly by L2b genovariant, although increasing cases associated with other L2 variants have been reported. Here, we assessed the distribution of rectal LGV genovariants among men having sex with men (MSM) in Italy. Read More

J Acquir Immune Defic Syndr 2021 Jan;86(1):e1-e5

Department of Clinical Sciences, Institute of Tropical Medicine, HIV/STI Unit, Antwerp, Belgium.

Background: An increase of lymphogranuloma venereum (LGV) in HIV negative men who have sex with men is reported in several European countries including Belgium before the implementation of pre-exposure prophylaxis (PrEP).

Setting: The epidemiological characteristics of the male rectal LGV epidemic in Belgium were explored before and after the introduction of PrEP.

Methods: Segmented regression models were used to examine a change in trends before and after the introduction of PrEP in the male rectal LGV epidemic in Belgium and among men attending a large HIV/sexually transmitted infection clinic in Antwerp, Belgium. Read More

Sex Transm Dis 2021 Feb;48(2):e33

Service of Infectious Diseases of Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Rev Gastroenterol Mex (Engl Ed) 2020 Aug 31. Epub 2020 Aug 31.

Unidad de Gastroenterología y Endoscopia Digestiva, Hospital Pablo Tobón Uribe, Medellín, Colombia.