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    1835 results match your criteria Lymphogranuloma Venereum

    1 OF 37

    Delayed diagnosis of lymphogranuloma venereum-associated colitis in a man first suspected to have rectal cancer.
    JRSM Open 2016 Jan 1;8(1):2054270416660933. Epub 2016 Dec 1.
    St George's Hospital, Tooting, London SW17 0QT, UK.
    Lymphogranuloma venereum-associated colitis is a diagnosis that should not be missed. The following case represents the importance of a thorough history, including the importance of the sexual history to prevent the misdiagnosis of these patients. Read More

    Co-infection by lymphogranuloma venereum and Haemophilus parainfluenzae during an episode of proctitis.
    Gastroenterol Hepatol 2017 Feb 10. Epub 2017 Feb 10.
    Servicio de Microbiología, Complejo Hospitalario Universitario de Granada-ibsGranada, Granada, España; Departamento de Microbiología, Universidad de Granada-ibsGranada, Granada, España. Electronic address:

    Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016.
    Euro Surveill 2017 Feb;22(5)
    Department of Phage and Molecular Typing, National Centre for Epidemiology, Budapest, Hungary.
    In eastern Europe, few countries have so far reported laboratory-confirmed cases of lymphogranuloma venereum (LGV). Here we describe 22 LGV cases in men who have sex with men (MSM) detected in Hungary from November 2012 to July 2016. Sequence analyses show that 16 of these 22 cases were affected by the L2c genovariant, with from 2012 to 2014, one LGV L2c case detected per year, followed by seven cases in 2015 and six up to July 2016. Read More

    Granulomatous & histiocytic dermatitides.
    Semin Diagn Pathol 2016 Dec 14. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical & Cytological Pathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:
    Granulomas of the skin may be classified in several ways. They are either infectious or non-infectious in character, and they contain areas of necrobiosis or necrosis, or not. Responsible infectious agents may be mycobacterial, fungal, treponemal, or parasitic organisms, and each case of granulomatous dermatitis should be assessed histochemically for those microbes. Read More

    [Reactive arthritis associated with Chlamydia trachomatis genovar L2b proctitis].
    Med Mal Infect 2016 Dec 9. Epub 2016 Dec 9.
    Service des maladies infectieuses et tropicales, hôpital Pellegrin, centre hospitalier universitaire de Bordeaux, place Amélie Raba-Léon, 33076 Bordeaux cedex, France; USC EA 3671, infections humaines à mycoplasmes et chlamydiae, université de Bordeaux, 33000 Bordeaux, France; Inra, USC EA 3671, infections humaines à mycoplasmes et chlamydiae, 33000 Bordeaux, France.

    Protection against genital tract Chlamydia trachomatis infection following intranasal immunization with a novel recombinant MOMP VS2/4 antigen.
    APMIS 2016 Dec;124(12):1078-1086
    Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    The asymptomatic nature of most Chlamydia trachomatis infections and the lack of appropriate effects by current prevention and management call for vaccine development. We evaluated a recombinant subunit vaccine candidate based on the major outer membrane protein variable segments 2 and 4 (MOMP VS2/4). To achieve maximal immunogenicity and ease of production and purification, MOMP VS2/4 was constructed by using highly immunogenic sequences of MOMP only, thereby minimizing the presence of hydrophobic regions, and spacing the immunogenic epitopes with a flexible amino acid sequence. Read More

    Impact of rapid diagnostic testing for chlamydia and gonorrhea on appropriate antimicrobial utilization in the emergency department.
    Diagn Microbiol Infect Dis 2017 Feb 18;87(2):175-179. Epub 2016 Oct 18.
    Department of Infectious Diseases, Mercy Health Saint Mary's, Grand Rapids, MI 49503, USA.
    Prolonged turnaround time of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) test results may delay time to notification and treatment of test-positive patients and result in unnecessary antimicrobial use in test-negative patients. This quasi-experimental study evaluated the impact of NG/CT rapid diagnostic testing (RDT) in an urban emergency department (ED) on treatment appropriateness, time to notification, and cost. Patients tested in December 2013-January 2014 (traditional group, n=200) were compared with those in December 2014-January 2015 (RDT group, n=200). Read More

    Changing Pattern of Chlamydia trachomatis Strains in Lymphogranuloma Venereum Outbreak, France, 2010-2015.
    Emerg Infect Dis 2016 Nov;22(11):1945-1947
    We describe a change in the molecular epidemiology of Chlamydia trachomatis strains involved in an outbreak of rectal lymphogranuloma venereum in France during January 2010-April 2015. Until 2012, the C. trachomatis L2b strain predominated; however, starting in 2013, most cases involved the L2 strain. Read More

    Lymphogranuloma venereum proctitis.
    Proc (Bayl Univ Med Cent) 2016 Oct;29(4):418-419
    Division of Cardiology (Harrison), Department of Internal Medicine (Som, Stroup), Oklahoma State University Medical Center, Tulsa, Oklahoma.
    We describe a 60-year-old man who presented with rectal pain and bleeding of a month's duration. His presentation was highly suggestive of lymphogranuloma venereum (LGV) proctitis. Nucleic acid amplification for chlamydia and gonorrhea via rectal swab revealed evidence supportive of anorectal chlamydia. Read More

    Diagnostic Procedures to Detect Chlamydia trachomatis Infections.
    Microorganisms 2016 Aug 5;4(3). Epub 2016 Aug 5.
    Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg 20246, Germany.
    The intracellular life style of chlamydia and the ability to cause persistent infections with low-grade replication requires tests with high analytical sensitivity to directly detect C. trachomatis (CT) in medical samples. Nucleic acid amplification tests (NAATs) are the most sensitive assays with a specificity similar to cell culture and are considered the method of choice for CT detection. Read More

    Notes from the Field: Cluster of Lymphogranuloma Venereum Cases Among Men Who Have Sex with Men - Michigan, August 2015-April 2016.
    MMWR Morb Mortal Wkly Rep 2016 Sep 2;65(34):920-1. Epub 2016 Sep 2.
    Lymphogranuloma venereum (LGV) is a sexually transmitted disease (STD) caused by infection with invasive Chlamydia trachomatis serovars L1-L3 (1). LGV is characterized by inguinal and/or femoral lymphadenopathy, typically following a transient, self-limited genital ulcer or papule that might go unnoticed. Rectal infection can result in proctocolitis that can present with mucoid and/or hemorrhagic rectal discharge, anal pain, constipation, fever, and tenesmus, and signs of granulomas and/or ulcerations on anoscopy (1,2). Read More

    Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men.
    Emerg Infect Dis 2016 Oct 15;22(10):1778-84. Epub 2016 Oct 15.
    Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. Read More

    A Case of Reactive Arthritis Associated With Lymphogranuloma Venereum Infection in a Woman.
    Sex Transm Dis 2016 Sep;43(9):584-6
    From the *Department of Microbiology, and †Department of Dermatology, DIMES, University of Bologna, Bologna, Italy.
    We report the first case of reactive arthritis associated with lymphogranuloma venereum (LGV) in an Italian human immunodeficiency virus-negative woman with urogenital and rectal Chlamydia trachomatis L2 serovar infection. The LGV-associated arthritis has to be considered even when classic symptoms of arthritis are missing and in case of asymptomatic or cryptic LGV localizations. Read More

    HIV and diarrhoea: what is new?
    Curr Opin Infect Dis 2016 Oct;29(5):486-94
    aTropical and Infectious Disease Unit, Royal Liverpool University Hospital bDepartment of Clinical Sciences, Liverpool School of Tropical Medicine cNational Institute for Health Research Health Protection Research Unit in Gastrointestinal Infection, University of Liverpool, Liverpool, UK.
    Purpose Of Review: The review examines the changing causes and the investigation of infectious and noninfectious diarrhoea in individuals with HIV.

    Recent Findings: Despite the excellent prognosis conferred by combination antiretroviral therapy, diarrhoea is still common in HIV-positive individuals and is associated with reduced quality of life and survival. There is increasing interest in the importance of Th17 and Th22 T cells in the maintenance of mucosal immunity within the gut, and in the role of the gut microbiome in gut homeostasis. Read More

    Approach to lymphogranuloma venereum.
    Can Fam Physician 2016 Jul;62(7):554-8
    Nurse practitioner at the Ottawa Public Health Sexual Health Centre.
    Objective: To review the literature about lymphogranuloma venereum (LGV) and to provide an overview and discussion of practice guidelines.

    Sources Of Information: The terms Chlamydia trachomatis and lymphogranuloma venereum were searched separately in PubMed. Empirical studies, practice reviews, and clinical guidelines were included. Read More

    A suspected case of lymphogranuloma venereum (LGV) suggests underdiagnosed LGV infection among Slovenian men who have sex with men.
    Acta Dermatovenerol Alp Pannonica Adriat 2016 Jun;25(2):35-7
    Zdrav Splet, Lackova cesta 54, Maribor, Slovenia.
    Lymphogranuloma venereum (LGV) is sexually transmitted infection caused by serovars of Chlamydia trachomatis, mostly seen among HIV-positive men who have sex with men. The first three reports of possible LGV in Slovenia were from April to June 2015, followed by a confirmed case of LGV in August 2015. We present the case of an HIV-positive MSM that presented with an anorectal abscess, discharge, lymphadenopathy, and unusual perianal plaque. Read More

    The Enigma of Lymphogranuloma Venereum Spread in Men Who Have Sex With Men: Does Ano-Oral Transmission Plays a Role?
    Sex Transm Dis 2016 Jul;43(7):420-2
    From the *STI Outpatient Clinic, Cluster of Infectious Diseases, Public Health Service Amsterdam; †Department of Dermatology, Academic Medical Centre, and ‡Centre for Infectious Diseases and Immunology (CINIMA), Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.

    Anorectal Lymphogranuloma Venereum in Madrid: A Persistent Emerging Problem in Men Who Have Sex With Men.
    Sex Transm Dis 2016 Jul;43(7):414-9
    From the *Division of Infectious Diseases, †Departments of Microbiology, ‡Department of Immunology, Fundación Jiménez Díaz, QuironSalud, Universidad Autónoma de Madrid; and §Department of Microbiology. Hospital Ramón y Cajal, Madrid, Spain.
    Background: Since 2003, outbreaks of lymphogranuloma venereum (LGV) with anorectal syndrome have been increasingly recognized in many Western countries. All of them have been classified as LGV serovar L2b, mainly occurring in human immunodeficiency virus (HIV)-infected men who have had sex with men (MSM). We describe a series of 26 diagnosed cases of LGV proctitis in downtown Madrid, Spain, in 2014, after implementing routine diagnostic procedures for this disease in symptomatic MSM. Read More

    Clinical and epidemiological characterisation of lymphogranuloma venereum in southwest Spain, 2013-2015.
    Sex Transm Infect 2016 Dec 9;92(8):629-631. Epub 2016 Jun 9.
    Unidad Clínica de Enfermedades Infecciosas y Microbiología (UCEIM), Hospital Universitario de Valme, Seville, Spain.
    Objectives: Lymphogranuloma venereum (LGV) infections caused by Chlamydia trachomatis L serovars have emerged in 2003 in Europe among HIV-positive men having sex with men (MSM). Our aim was to evaluate LGV prevalence and predictors in a high-risk population attending to two STI clinics in the southwest of Spain between December 2013 and April 2015.

    Methods: Screening of C. Read More

    Isolated bilateral inguinal lymphadenopathy in the absence of other symptoms, due to LGV in known HIV-positive MSM: is it more common than we think?
    BMJ Case Rep 2016 Jun 2;2016. Epub 2016 Jun 2.
    GUM/HIV, ABM University Health Board, Singleton Hospital, Swansea, UK.
    The current resurgence of lymphogranuloma venereum (LGV) has drawn most attention to its potential for causing proctitis; however, this case highlights the need for awareness of LGV as a cause of isolated painful bilateral inguinal lymphadenopathy in a high-risk population and the importance of routine screening for LGV. We describe a case of a 37-year-old HIV positive man, in the population of men who have sex with men (MSM) who presented with bilateral enlarged inguinal lymph nodes and no other symptoms or signs. Urine nucleic acid amplification test was positive for chlamydia LGV-specific DNA. Read More

    Did L Strains Responsible for Lymphogranuloma Venereum Proctitis Spread Among People With Genital Chlamydia trachomatis Infection in France in 2013?
    Sex Transm Dis 2016 Jun;43(6):374-6
    From the *University of Bordeaux and †INRA, USC EA3671 Mycoplasmal and Chlamydial Infections in Humans, and National Reference Center for Chlamydia, Bordeaux; ‡STI Center CDAG-CIDDIST CG13, Marseille; §AP-HP, University Hospital Saint Louis, Paris; ¶STI Center CDAG-CIDDIST CG33, Bordeaux; ∥STI Center CDAG CIDDIST CG 75; and **AP-HP, Département de Bactériologie, Groupe Hospitalier des Hôpitaux Universitaires de l'Est Parisien, Paris, France.
    We retrospectively analyzed 1802 nonrectal Chlamydia trachomatis-positive specimens to determine if the L strains responsible for rectal Lymphogranuloma venereum in men who have sex with men could spread to the heterosexual population. No evidence for Lymphogranuloma venereum transmission among heterosexuals in France was observed in 2013. L2b strains seem to be restricted to the men who have sex with men population. Read More

    Enhanced surveillance of a lymphogranuloma venereum outbreak in Sydney 2010-2012.
    Aust N Z J Public Health 2016 Aug 15;40(4):368-70. Epub 2016 May 15.
    The Kirby Institute, UNSW Australia, New South Wales.
    Objectives: To investigate an increase in lymphogranuloma venereum (LGV) notifications in New South Wales (NSW).

    Methods: Enhanced surveillance of notified LGV cases in NSW between May 2010 and April 2012 using doctor and patient questionnaires.

    Results: Thirty-seven doctors who had diagnosed 67 (76%) of 88 notified anorectal LGV infections were interviewed. Read More

    Higher organism load associated with failure of azithromycin to treat rectal chlamydia.
    Epidemiol Infect 2016 Sep 16;144(12):2587-96. Epub 2016 May 16.
    Melbourne School of Population and Global Health,University of Melbourne,Victoria,Australia.
    Repeat rectal chlamydia infection is common in men who have sex with men (MSM) following treatment with 1 g azithromycin. This study describes the association between organism load and repeat rectal chlamydia infection, genovar distribution, and efficacy of azithromycin in asymptomatic MSM. Stored rectal chlamydia-positive samples from MSM were analysed for organism load and genotyped to assist differentiation between reinfection and treatment failure. Read More

    Syphilitic lymphadenitis clinically and histologically mimicking lymphogranuloma venereum.
    S Afr Med J 2016 Apr 19;106(5):49-51. Epub 2016 Apr 19.
    Groote Schuur Hospital, Cape Town, South Africa.
    An inguinal lymph node was discovered incidentally during surgery for a suspected strangulated inguinal hernia. The patient had recently been treated for candidal balanoposthitis and was known to have a paraphimosis. A new foreskin ulcer was discovered when he was admitted for the hernia surgery. Read More

    DNA stability of Chlamydia trachomatis and Neisseria gonorrhoeae in urine.
    Diagn Microbiol Infect Dis 2016 Jul 12;85(3):313-4. Epub 2016 Apr 12.
    Université de Lille, UFR Médecine, F-59000 Lille, France; CHU Lille, Institut de Microbiologie, F-59000 Lille, France.
    We evaluated the DNA stability of Chlamydia trachomatis and Neisseria gonorrhoeae in 55 urine samples. Crossing threshold (Ct) values were highly similar after 3 to 14 days at room temperature (+0.002, P = 0. Read More

    Lymphogranuloma venereum presenting with erythema nodosum.
    Int J STD AIDS 2016 Dec 15;27(14):1354-1355. Epub 2016 Apr 15.
    Department of Internal Medicine, Spaarne Gasthuis, Haarlem, Netherlands.
    Lymphogranuloma venereum is a sexually transmitted infection caused by Chlamydia trachomatis serovar L1, L2 or L3. Anorectal infections in HIV-positive men who have sex with men comprise the majority of cases in the developed world. We present the case of a 30-year-old HIV-negative man with inguinal type lymphogranuloma venereum accompanied by erythema nodosum. Read More

    Chlamydia trachomatis infection prevalence and serovar distribution in a high-density urban area in the north of Italy.
    J Med Microbiol 2016 Jun 5;65(6):510-20. Epub 2016 Apr 5.
    1​ Microbiology, DIMES, University of Bologna, Bologna, Italy.
    The aim of this study was to assess Chlamydia trachomatis (CT) infection prevalence and serovar distribution in a high-density urban area in the north of Italy, by comparing different groups of subjects divided on the basis of the type of care provider they referred to (STI Clinic, gynaecologists or general practitioners). From January 2011 to May 2014, all the specimens submitted to the Microbiology Laboratory of St Orsola Hospital in Bologna for CT detection were tested by PCR assay. For positive specimens, molecular genotyping based on RFLP analysis was performed. Read More

    The L2b real-time PCR targeting the pmpH gene of Chlamydia trachomatis used for the diagnosis of lymphogranuloma venereum is not specific to L2b strains.
    Clin Microbiol Infect 2016 Jun 31;22(6):574.e7-9. Epub 2016 Mar 31.
    University of Bordeaux, USC EA3671 Mycoplasmal and Chlamydial Infections in Humans, and National Reference Centre for Chlamydia, France; INRA, USC EA3671 Mycoplasmal and Chlamydial Infections in Humans, and National Reference Centre for Chlamydia, France; Bacteriology Department, Bordeaux University Hospital, Bordeaux, France. Electronic address:
    The French Reference Centre for chlamydiae uses two real-time PCRs targeting the pmpH gene of Chlamydia trachomatis to differentiate between L strains and variant L2b, responsible for a lymphogranuloma venereum outbreak in Europe. We compared the results obtained for 122 L2b C. trachomatis-positive specimens, using the two real-time PCRs, with the sequencing of the ompA gene. Read More

    Steady increase of lymphogranuloma venereum cases, Czech Republic, 2010 to 2015.
    Euro Surveill 2016 ;21(11):30165
    Department of Dermatovenerology, Second Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic.
    Since the notification of the first case of lymphogranuloma venereum (LGV) in the Czech Republic in 2010, the numbers of LGV cases have steadily increased in the country. In 2015, 40 LGV cases were diagnosed, bringing the total for 2010-2015, to 88 cases. The profile of the most affected group, HIV-positive men who have sex with men with a previous sexually transmitted infection, matches that of those described in LGV outbreaks in western Europe. Read More

    Genotyping and prevalence of Chlamydia trachomatis infection among women in Belém, Pará, northern Brazil.
    J Infect Dev Ctries 2016 Feb 28;10(2):134-7. Epub 2016 Feb 28.
    Instituto Evandro Chagas, Laboratório de Infecções Respiratórias de Origem Bacteriana, Ananindeua, Pará, Brasil.
    Introduction: Genital Chlamydia trachomatis infection is one of the most prevalent sexually transmitted diseases in women, and undetected cases of the disease are highly associated with long-term complications. Despite the high prevalence of infections in Brazil, very little is known about the distribution of C. trachomatis genovars. Read More

    Medical Examination of Aliens--Revisions to Medical Screening Process. Final rule.
    • Authors:
    Fed Regist 2016 Jan;81(16):4191-206
    The Centers for Disease Control and Prevention (CDC), within the Department of Health and Human Services (HHS), is issuing this final rule (FR) to amend its regulations governing medical examinations that aliens must undergo before they may be admitted to the United States. Based on public comment received, HHS/CDC did not make changes from the NPRM published on June 23, 2015. Accordingly, this FR will: Revise the definition of communicable disease of public health significance by removing chancroid, granuloma inguinale, and lymphogranuloma venereum as inadmissible health-related conditions for aliens seeking admission to the United States; update the notification of the health-related grounds of inadmissibility to include proof of vaccinations to align with existing requirements established by the Immigration and Nationality Act (INA); revise the definitions and evaluation criteria for mental disorders, drug abuse and drug addiction; clarify and revise the evaluation requirements for tuberculosis; clarify and revise the process for the HHS/CDC-appointed medical review board that convenes to reexamine the determination of a Class A medical condition based on an appeal; and update the titles and designations of federal agencies within the text of the regulation. Read More

    The use of trimethoprim and sulfamethoxazole (TMP-SMX) in dermatology.
    Folia Med Cracov 2015 ;55(1):35-41
    Department of Dermatology Jagiellonian University Medical College, Skawinska 8, Krakow, Poland.
    We analyzed publications and articles in the PubMed database about the use of trimethoprim and sulfamethoxazole (TMP-SMX) in dermatology. Literature published in the English language, at least in the past two decades, was reviewed. Specific dermatologic indications for TMP-SMX are few but it is often used as the second- or third- line agent. Read More

    Chlamydial Proctitis in a Young Man Who Has Sex with Men: Misdiagnosed as Inflammatory Bowel Disease.
    Chonnam Med J 2015 Dec 11;51(3):139-41. Epub 2015 Dec 11.
    Department of Internal Medicine, National Police Hospital, Seoul, Korea.
    We report the case of a 20-year-old man with a 2-month history of anal pain and bloody rectal discharge. He was referred to our clinic of gastroenterology for suspected inflammatory bowel disease (IBD). The colonoscopy showed mucosal nodularities on the rectum and an anal tag. Read More

    Travel-related sexually transmitted infections.
    Int Marit Health 2015 ;66(4):238-46
    Head of Department of Epidemiology and Tropical Medicine, Military Institute of Medicine, Warsaw, Poland.
    Sexually transmitted infections (STIs) are among the most common notifiable health problems worldwide, with particularly high rates in developing countries. Men and women with multiple sexual partners at home or a previous history of STIs are more likely to have casual sexual exposure (CSE) while travelling. Over the last several decades 5% to even 50% of short-term travellers engaged in CSE during foreign trips. Read More

    Sexually Transmitted Infections: Experience in a Multidisciplinary Clinic in a Tertiary Hospital (2010-2013).
    Actas Dermosifiliogr 2016 Apr 19;107(3):235-41. Epub 2015 Dec 19.
    Servicio de Dermatología, Hospital Clínic, Universitat de Barcelona, Barcelona, España. Electronic address:
    Introduction: The number of consultations for sexually transmitted infections (STIs) is increasing in Spain. The aim of this study was to describe and analyze the epidemiological, behavioral, clinical, and microbiological characteristics of patients registered at the STI unit of a tertiary hospital.

    Methods: This was a retrospective, single-center descriptive study carried out between 2010 and 2013 in a multidisciplinary unit specialized in STIs, situated in a tertiary hospital. Read More

    Asymptomatic Lymphogranuloma Venereum in Men who Have Sex with Men, United Kingdom.
    Emerg Infect Dis 2016 Jan;22(1):112-6
    We investigated prevalence of lymphogranuloma venereum (LGV) among men who have sex with men who were tested for chlamydia at 12 clinics in the United Kingdom during 10 weeks in 2012. Of 713 men positive for Chlamydia trachomatis, 66 (9%) had LGV serovars; 15 (27%) of 55 for whom data were available were asymptomatic. Read More

    Rapid increase in lymphogranuloma venereum in men who have sex with men, United Kingdom, 2003 to September 2015.
    Euro Surveill 2015 ;20(48):30076
    HIV and STI Department, Public Health England Health Protection Services, Colindale, United Kingdom.
    United Kingdom (UK) national data show a sharp increase in diagnoses of lymphogranuloma venereum (LGV) since 2012. Most cases are in men who have sex with men (MSM) living in London, with high rates of co-infection with HIV and other sexually transmitted infections. In light of these data, and the recent finding that one quarter of LGV infections may be asymptomatic, clinicians should be vigilant in testing for LGV, including in asymptomatic HIV-positive MSM. Read More

    2015 European guideline on the management of Chlamydia trachomatis infections.
    Int J STD AIDS 2016 Apr 24;27(5):333-48. Epub 2015 Nov 24.
    WHO Collaborating Center for Gonorrhoea and other Sexually Transmitted Infections, National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
    Chlamydia trachomatis infections, which most frequently are asymptomatic, are major public health concerns globally. The 2015 European C. trachomatis guideline provides: up-to-date guidance regarding broader indications for testing and treatment of C. Read More

    Lymphogranuloma Venereum 2015: Clinical Presentation, Diagnosis, and Treatment.
    Clin Infect Dis 2015 Dec;61 Suppl 8:S865-73
    San Francisco Department of Public Health Division of Infectious Diseases, University of California, San Francisco.
    Lymphogranuloma venereum (LGV) has emerged as an important cause of proctitis and proctocolitis in men who have sex with men; classical inguinal presentation is now increasingly uncommon. We report summary findings of an extensive literature review on LGV clinical presentation, diagnosis, and treatment that form the evidence base for the 2015 Centers for Disease Control and Prevention treatment guidelines for sexually transmitted diseases. Proctitis and proctocolitis are now the most commonly reported clinical manifestations of LGV, with symptoms resembling those of inflammatory bowel disease. Read More

    TLR2, TLR4 and TLR9 genotypes and haplotypes in the susceptibility to and clinical course of Chlamydia trachomatis infections in Dutch women.
    Pathog Dis 2016 Feb 13;74(1):ftv107. Epub 2015 Nov 13.
    Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, 1081 HV, the Netherlands.
    Chlamydia trachomatis infections demonstrate remarkable differences in clinical course that are approximately 40% based on host genetic variation. Here, we study the single nucleotide polymorphisms (SNPs) and their haplotypes in TLR2, TLR4 and TLR9 (TLR2 +2477G>A; TLR2 -16934T>A; TLR4+896A>G; TLR9 -1237T>C and TLR9 +2848G>A) in relation to the susceptibility to, and severity of C. trachomatis infections. Read More

    A case of syphilitic anal condylomata lata mimicking malignancy.
    Int J Surg Case Rep 2015 4;17:69-71. Epub 2015 Nov 4.
    Department of Colorectal surgery, University Hospital of North Tees, Hardwick, Stockton on Tees, TS19 8PE, UK. Electronic address:
    Introduction: Condylata lata in secondary syphilis is well known presentation and needs to be considered in differential diagnosis of perianal lesions. In England between 2013 and 2014 the overall incidence of infectious syphilis increased by 33% and is mainly seen in men who have sex with men.

    Presentation Of Case: We report the management of a 49-years-old Caucasian homosexual man with perianal lesions that were suspicious of malignancy. Read More

    2015 UK national guideline for the management of infection with Chlamydia trachomatis.
    Int J STD AIDS 2016 Mar 4;27(4):251-67. Epub 2015 Nov 4.
    British Association for Sexual Health and HIV Clinical Effectiveness Group, London, UK.
    This guideline offers recommendations on the diagnostic tests, treatment regimens and health promotion principles needed for the effective management of Chlamydia trachomatis genital infection. It covers the management of the initial presentation, as well the prevention of transmission and future infection. The guideline is aimed at individuals aged 16 years and older presenting to healthcare professionals working in departments offering Level 3 care in sexually transmitted infections management within the UK. Read More

    CXCL10, CXCL11, HLA-A and IL-1β are induced in peripheral blood mononuclear cells from women with Chlamydia trachomatis related infertility.
    Pathog Dis 2016 Feb 27;74(1):ftv099. Epub 2015 Oct 27.
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia Wesley and St Andrews Research Institute, The Wesley Hospital, Auchenflower, QLD 4066, Australia
    Chlamydia trachomatis infections can result in the development of serious sequelae such as pelvic inflammatory disease and tubal infertility. In this study, peripheral blood mononuclear cells from women who were undergoing or had recently undergone IVF treatment were cultured ex vivo with C. trachomatis to identify the immune responses associated with women who had serological evidence of a history of Chlamydia infection. Read More

    Microbiological Characteristics of Chlamydia trachomatis and Neisseria gonorrhoeae Infections in South African Women.
    J Clin Microbiol 2016 Jan 28;54(1):200-3. Epub 2015 Oct 28.
    Institute for Public Health Genomics (IPHG), Department of Genetics and Cell Biology, Research School GROW (School for Oncology & Developmental Biology), Faculty of Health, Medicine & Life Sciences, University of Maastricht, Maastricht, the Netherlands Department of Medical Microbiology & Infection Control, Laboratory of Immunogenetics, VU University Medical Center, Amsterdam, the Netherlands
    We analyzed data of 263 women with at least one genital or anorectal sexually transmitted infection from a cross-sectional study conducted in rural South Africa. We provide new insights concerning the concurrence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, and Trichomonas vaginalis infections as well as the characteristics of bacterial loads. Read More

    Sexually transmitted infectious colitis vs inflammatory bowel disease: distinguishing features from a case-controlled study.
    Am J Clin Pathol 2015 Nov;144(5):771-81
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD.
    Objectives: Sexually transmitted infectious (STI) colitis often raises concern for inflammatory bowel disease (IBD). In this study, we compare histologic features of IBD with STI colitis caused by syphilis and lymphogranuloma venereum.

    Methods: The STI colitis group included 10 unique colorectal biopsy specimens in patients with clinically confirmed syphilis and/or lymphogranuloma venereum. Read More

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