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Indian J Pathol Microbiol 2022 Apr-Jun;65(2):406-409

Department of Pediatric Surgery, IPGMER, Kolkata, West Bengal, India.

The most common cause of granulomatous lymphadenitis in countries like ours is mycobactrium tuberculosis followed by atypical mycobacterial infection, fungal infections, parasitic infection, cat scratch disease, lymphogranuloma venereum (inguinal lymphadenopathy), and leprosy Here, we present three cases of lymphadenopathy due to histoplasmosis in immunocompetent children. Two of them presented with fever, lymphadenopathy, initially diagnosed as granulomatous lymphadenitis consistent with tuberculosis on FNAC and were put on antitubercular drugs. However, their condition gradually became worse. Read More

Int J Mol Sci 2022 Apr 1;23(7). Epub 2022 Apr 1.

Department of Public Health and Infectious Diseases, University of Rome "Sapienza", P.le Aldo Moro 5, 00185 Rome, Italy.

, an obligate intracellular Gram-negative bacterium, is characterized by a wide range of different serotypes responsible for several local or systemic human diseases, including genital tract manifestations (D-K), trachoma (A-C), and lymphogranuloma venereum (L1-3) [... Read More

Sex Transm Dis 2022 Apr 9. Epub 2022 Apr 9.

National Reference Laboratory for Sexually Transmitted Infections - Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal.

Abstract: Between 2001 and 2020, 54 LGV cases were diagnosed in an STD clinic in Lisbon, most in MSM (87%), HIV-negative (63%), from anorectal mucosa (72.2%). Cases among heterosexuals were also identified (13%). Read More

Int J STD AIDS 2022 Apr 18;33(5):456-461. Epub 2022 Mar 18.

WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, 98836Örebro University, Örebro, Sweden.

Background: Several lymphogranuloma venereum (LGV) outbreaks among men who have sex with men (MSM) have been reported throughout the world since 2003. Nevertheless, no LGV cases have been internationally reported from Russia. We evaluated the prevalence of LGV among MSM attending proctologists in Moscow, Russia, and compared the LGV and non-LGV rectal (CT) infections. Read More

Sex Transm Infect 2022 Feb 25. Epub 2022 Feb 25.

Melbourne Sexual Health Centre, Alfred Health, Carlton, Victoria, Australia.

Background: Lymphogranuloma venereum (LGV) is caused by serovars L1-L3. This study determined the positivity for LGV testing before and after introduction of universal LGV testing of positive rectal samples in men who have sex with men (MSM).

Methods: From March 2015 to February 2018, MSM with rectal were not routinely tested for LGV at the Melbourne Sexual Health Centre unless they had HIV or symptoms of proctitis. Read More

Wellcome Open Res 2021 16;6:312. Epub 2021 Nov 16.

Clinical and Experimental Sciences, University of Southampton, Southampton, Hampshire, SO166YD, UK.

is a prolific human pathogen that can cause serious long-term conditions if left untreated. Recent developments in genetics have opened the door to conducting targeted and random mutagenesis experiments to identify gene function. In the present study, an inducible transposon mutagenesis approach was developed for using a self-replicating vector to deliver the transposon-transposase cassette - a significant step towards our ultimate aim of achieving saturation mutagenesis of the genome. Read More

Diagn Microbiol Infect Dis 2022 Apr 28;102(4):115610. Epub 2021 Nov 28.

Microbiology Department, Ramón y Cajal Hospital, Madrid, Spain; Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain; Network Center for Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain. Electronic address:

The population dissemination of invasive genotypes of C. trachomatis and an increase of urogenital infections cases by non-invasive genotypes have been observed in many countries. In this epidemiological context, the descriptions of a high proportion of infections related to L-genotypes in asymptomatic patients, but also to infections caused by non-L genotypes in symptomatic patients have been unexpected finding. Read More

Clin Nucl Med 2022 Mar;47(3):e265-e267

From the Department of Haematology and Bone Marrow Transplantation, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital.

Abstract: A 42-year-old man presented with painless, left inguinal lymphadenopathy, which was suspicious of malignant lymphoma. Multiple left-sided foci of markedly increased metabolic activity were observed on PET/CT (SUVmax up to 22.3), located at the inguinal, iliac, and para-aortic lymph nodes along with small-sized right inguinal lymphadenopathy. Read More

Cureus 2021 Dec 6;13(12):e20216. Epub 2021 Dec 6.

Infectious Diseases, Waterbury Hospital, Waterbury, USA.

Lymphogranuloma venereum (LGV) can present as a sexually transmitted anorectal syndrome and is caused by  serotypes L1, L2, and L3. It was rare in the western world until a recent outbreak among men who have sex with men (MSM) in Europe and North America. Limited availability of diagnostic tests differentiating LGV from non-LGV  can make the diagnosis challenging. Read More

CMAJ 2021 12;193(49):E1889

Vancouver Coastal Health, Division of Medical Microbiology & Infection Control (Eckbo), University of British Columbia, Faculty of Medicine, Department of Pathology & Laboratory Medicine (Eckbo); Spectrum Health (Hedgcock); British Columbia Centre for Disease Control, STI/HIV Services (Grennan); University of British Columbia, Faculty of Medicine, Division of Infectious Diseases (Grennan), Vancouver, BC.

BMJ Open 2021 12 13;11(12):e052817. Epub 2021 Dec 13.

Centre of Epidemiological Studies of Sexually Transmitted Disease and AIDS in Catalonia (CEEISCAT), Department of Health, Generalitat of Catalonia, Badalona, Spain.

Objectives: To describe the epidemiology of sexually transmitted infections (STIs), identify and characterise socio-epidemiological clusters and determine factors associated with HIV coinfection.

Design: Retrospective population-based cohort.

Setting: Catalonia, Spain. Read More

Ned Tijdschr Geneeskd 2021 10 14;165. Epub 2021 Oct 14.

Spaarne Gasthuis, afd. Interne Geneeskunde, Hoofddorp.

Background: Syphilis is a sexually transmitted disease, caused by the spirochete Treponema Pallidum. Many different manifestations exist, which can complicate diagnosis.

Case: A 36-year-old man with a known HIV infection, presented himself with rectal blood loss and abdominal pain. Read More

Int J Infect Dis 2022 Feb 25;115:106-108. Epub 2021 Nov 25.

Division of Infectious Diseases. Fundación Jiménez Díaz University Hospital. Universidad Autónoma de Madrid (IIS-FJD, UAM). Madrid, Spain.

Sweet Syndrome belongs to a group of diseases known as neutrophilic dermatoses. An uncommon variant named Histiocytoid Sweet Syndrome (HSS) can be associated with a variety of conditions, including cancer, infections, drug toxicity and others. Here we present an instance of HSS in an HIV-positive patient in an infectious disease setting. Read More

Lakartidningen 2021 11 2;118. Epub 2021 Nov 2.

docent, klinisk mikrobiologi, Akademiska sjukhuset, Uppsala.

Chlamydial infection is the most common bacterial sexually transmitted infection in Sweden and worldwide, despite extensive testing, efficient treatment and partner notification. The incidence of Lymphogranuloma venereum, currently occurring among men who have sex with men and most often in the rectum, shows no tendency to decline. This infection is usually symptomatic but still evading diagnosis due to similarities to other causes of proctitis. Read More

Mol Cell Biochem 2022 Jan 15;477(1):205-212. Epub 2021 Oct 15.

The First People's Hospital of Chenzhou, The First School of Clinical Medicine, Southern Medical University, Chenzhou, 423000, People's Republic of China.

Chlamydia trachomatis is one of the most common pathogens of sexually transmitted diseases, and its incidence in genital tract infections is now 4.7% in south China. Infertility is the end result of C. Read More

Diagn Microbiol Infect Dis 2021 Dec 27;101(4):115532. Epub 2021 Aug 27.

Division of STD Prevention, National Center for HIV, Hepatitis, STD, TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Lymphogranuloma venereum (LGV) can be differentiated from non-LGV chlamydial infection using Sanger sequencing or molecular assays, including those that are commercially-available internationally. Here, we describe the performance of a rapid real-time PCR (RT-PCR)-based strategy in differentiating Chlamydia trachomatis infections associated with LGV or non-LGV serovars. One hundred three rectal swabs, previously genotyped using Sanger sequencing of the ompA gene as a reference method, were tested in the RT-PCR assays. Read More

Emerg Infect Dis 2021 10;27(10):2695-2699

Incidence of lymphogranuloma venereum increased in England during 2018-2019, after a period of decline. Our retrospective analysis of national surveillance data identified a rapid increase in diagnoses among HIV-negative men who have sex with men. These findings indicate a need for sustained surveillance and targeted public health action. Read More

BMC Public Health 2021 09 7;21(1):1637. Epub 2021 Sep 7.

Centre of epidemiological studies on sexually transmitted infections and AIDS of Catalonia (CEEISCAT). Department of Health. Generalitat of Catalonia, Badalona, Spain.

Background: Before the COVID-19 pandemic, Sexually transmitted infections (STIs) were increasing in Europe, and Spain and Catalonia were not an exception. Catalonia has been one of the regions with the highest number of COVID-19 confirmed cases in Spain. The objective of this study was to estimate the magnitude of the decline, due to the COVID-19 pandemic, in the number of STI confirmed cases in Catalonia during the lockdown and de-escalation phases. Read More

J Eur Acad Dermatol Venereol 2022 Jan 19;36(1):e69-e70. Epub 2021 Sep 19.

Department of Dermatology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.

Int J STD AIDS 2021 12 14;32(14):1318-1325. Epub 2021 Aug 14.

62963Universidad de Buenos Aires, 62963Facultad de Farmacia y Bioquímica, Cátedra de Microbiología Clínica, Buenos Aires, Argentina.

Background: (CT) can infect the anorectum producing various signs and symptoms. There is scarce literature regarding the differences between LGV and non-LGV CT anorectal manifestations. We compare the clinical spectrum of LGV and non-LGV infections. Read More

Enferm Infecc Microbiol Clin (Engl Ed) 2021 Oct 3;39(8):390-394. Epub 2021 Aug 3.

Servicio de Microbiología, Hospital Universitario Central de Asturias, Oviedo, Asturias; Área de Microbiología, Facultad de Medicina, Universidad de Oviedo; Grupo de Microbiología Translacional, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA); Instituto Universitario Fernández Vega (IUFV) y Fundación de Investigación Oftalmológica (FIO), Oviedo; Grupo de Estudio de Infecciones de Transmisión Sexual, GEITS, SEIMC, Spain.

Background: Scarce information is available on the resources to deal with the Sexually Transmitted Infections (STIs), both in the clinic and in the laboratory. The objective is to describe and know the reality of the clinics and laboratories that treat these infections in Spain.

Methods: Cross-sectional observational study with data collection through a survey aimed at the members of the GEITS Group. Read More

Rev Esp Enferm Dig 2022 04;114(4):226-227

UGC Aparato Digestivo, Hospital Universitario Clínico San Cecilio, España.

We report two cases of proctitis in men having sex with men. Read More

J Eur Acad Dermatol Venereol 2021 Aug;35(8):1606-1607

Dermatology Unit, Ospedale Policlinico San Martino, Genoa, Italy.

PLoS One 2021 8;16(7):e0254233. Epub 2021 Jul 8.

Public Health England, Porton Down, Salisbury, United Kingdom.

Background: Lymphogranuloma venereum (LGV) is caused by Chlamydia trachomatis strains with ompA genotypes L1 to L3. An LGV epidemic associated with the L2b genotype has emerged in the past few decades amongst men who have sex with men (MSM). C. Read More

Microb Genom 2021 06;7(6)

Clinical Bacteriology & Mycology, University Hospital Basel, University of Basel, Switzerland.

Lymphogranuloma venereum (LGV), the invasive infection of the sexually transmissible infection (STI) , is caused by strains from the LGV biovar, most commonly represented by -genotypes L2b and L2. We investigated the diversity in LGV samples across an international collection over seven years using typing and genome sequencing. LGV-positive samples (=321) from eight countries collected between 2011 and 2017 (Spain =97, Netherlands =67, Switzerland =64, Australia =53, Sweden =37, Hungary =31, Czechia =30, Slovenia =10) were genotyped for and variants. Read More

Lancet Infect Dis 2021 07;21(7):1049

Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Rev Gastroenterol Mex (Engl Ed) 2021 Jul-Sep;86(3):313-315. Epub 2021 Jun 19.

Unidad de Gastroenterología y Endoscopia Digestiva, Hospital Pablo Tobón Uribe, Medellín, Colombia.

Int J Dermatol 2022 Jan 21;61(1):e5-e6. Epub 2021 Jun 21.

Department of Internal Medicine, Ho Chi Minh City University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.

Sex Transm Dis 2022 01;49(1):e26-e28

Association of Public Health Laboratories, Silver Spring, MD.

Abstract: The frequency of lymphogranuloma venereum or invasive Chlamydia trachomatis infection with serovar L1, L2, or L3 is unknown in the United States. While no diagnostic test is commercially available, we used a laboratory-developed test and detected lymphogranuloma venereum-associated serovar L2 in 14% of 132 remnant C. trachomatis-positive rectal swabs. Read More