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    1887 results match your criteria Lymphogranuloma Venereum

    1 OF 38

    Sexually transmitted diseases of the anus and rectum: Causal agents, coinfections, HIV infection and high-risk sexual behaviour.
    Med Clin (Barc) 2018 Apr 18. Epub 2018 Apr 18.
    Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, España. Electronic address:
    Introduction And Objective: Sexually transmitted infections of the rectum and anus (STI-RA) mainly affect men who have sex with men (MSM). The incidence of STI-RA among them has increased in recent years.

    Material And Methods: Retrospective study in patients with diagnoses of STI-RA in an STI unit during the years 2014 and 2015. Read More

    Lymphogranuloma venereum genovar L2b concomitantly with syphilis and hepatitis C in a male patient in Poland – case report
    Przegl Epidemiol 2018 ;72(1):45-51
    WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Ӧrebro University, Ӧrebro,Sweden
    We describe the first case of lymphogranuloma venereum (LGV) in Poland, with inguino-femoral lymphadenopathy, diagnosed and successfully treated according to the 2013 European LGV guideline. Chlamydia trachomatis genovar L2b, mainly responsible for the ongoing LGV epidemics among men who have sex with men (MSM) in Western European countries, was confirmed. The case also verified that co-infections with other sexually transmitted infections (syphilis and hepatitis C virus) are frequent in MSM LGV patients, as well as the very large difficulties with contact tracing for these patients. Read More

    Trends in the relative prevalence of genital ulcer disease pathogens and association with HIV infection in Johannesburg, South Africa, 2007-2015.
    PLoS One 2018 4;13(4):e0194125. Epub 2018 Apr 4.
    Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia.
    Background: In South Africa, treatment of genital ulcer disease (GUD) occurs in the context of syndromic management. GUD aetiological studies have been conducted in Johannesburg since 2007. We report on GUD pathogen prevalence, sero-prevalence of STI co-infections and aetiological trends among GUD patients presenting to a community-based primary healthcare facility in Johannesburg over a 9-year period. Read More

    Lymphogranuloma venereum among patients presenting at the HIV/STI clinic in Antwerp, Belgium : a case series.
    Acta Gastroenterol Belg 2017 Jul-Sep;80(3):385-387
    Institute of Tropical Medicine, Clinical Sciences.
    Objective of this study was to describe the patient characteristics and clinical presentation of laboratory confirmed lymphogranuloma venereum (LGV) cases, diagnosed at the Institute of Tropical Medicine (ITM), Antwerp, Belgium. Demographic and biomedical characteristics of all patients with chlamydia-positive sample results were retrieved for the years 2013 and 2014. Samples were obtained from both symptomatic and asymptomatic patients who consulted at the HIV/STI clinic. Read More

    Chlamydia trachomatis in Cervical Lymph Node of Man with Lymphogranuloma Venereum, Croatia, 2014.
    Emerg Infect Dis 2018 Apr;24(4):806-808
    We report an HIV-infected person who was treated for lymphogranuloma venereum cervical lymphadenopathy and proctitis in Croatia in 2014. Infection with a variant L2b genovar of Chlamydia trachomatis was detected in a cervical lymph node aspirate. A prolonged course of doxycycline was required to cure the infection. Read More

    Unusual case of a rectal tumour.
    BMJ Case Rep 2018 Mar 15;2018. Epub 2018 Mar 15.
    Epsom and Saint Helier University Hospitals NHS Trust, Carshalton, UK.
    A 48-year-old man presented as an emergency with a 3-week history of rectal bleeding. Examination of his rectum revealed a circumferential tumour, 2 cm from the anal verge. An MRI scan reported a locally infiltrative mid-lower rectal tumour staged as T3d/T4 N2 MX. Read More

    [Haemorrhagic proctocolitis as primary manifestation of lymphogranuloma venereum in an HIV-positive male].
    Ugeskr Laeger 2018 Mar;180(11)
    This is a case report of lymphogranuloma venereum (LGV) manifesting as haemorrhagic proctocolitis in a homosexual HIV-positive male. The primary symptom was a rectal abscess, which was initially surgically treated and subsequently insufficiently treated with single-dose tablet azithromycin. The patient's symptoms were successfully treated after a 21-day doxycycline regime. Read More

    Observed treatment responses to short-course doxycycline therapy for rectal lymphogranuloma venereum (LGV) in men who have sex with men.
    Sex Transm Dis 2017 Dec 7. Epub 2017 Dec 7.
    Background: Lymphogranuloma venereum (LGV) has re-established itself as an endemic sexually transmitted infection (STI) in the UK and elsewhere in Europe and North America over the last decade. Current guidelines suggest treatment with 21 days of doxycycline; however, the evidence base for LGV treatment including its duration is very limited.

    Methods: We conducted a retrospective review in two central London genitourinary medicine (GUM) clinics of men who have sex with men (MSM) with LGV in whom less than 21 days of doxycycline was used initially. Read More

    Plasmid Negative Regulation of CPAF Expression Is Pgp4 Independent and Restricted to Invasive Biovars.
    MBio 2018 Jan 30;9(1). Epub 2018 Jan 30.
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease. isolates are classified into 2 biovars-lymphogranuloma venereum (LGV) and trachoma-which are distinguished biologically by their natural host cell infection tropism. LGV biovars infect macrophages and are invasive, whereas trachoma biovars infect oculo-urogenital epithelial cells and are noninvasive. Read More

    Asymptomatic lymphogranuloma venereum among Nigerian men who have sex with men.
    Sex Transm Infect 2018 Jan 29. Epub 2018 Jan 29.
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Objectives: Recent outbreaks of anorectal lymphogranuloma venereum (LGV) among men who have sex with men (MSM) have been characterised by proctocolitis requiring extended antibiotic treatment compared with infections caused by other serovars of (CT). We describe the prevalence and clinical features of LGV among Nigerian MSM diagnosed with anorectal CT.

    Methods: MSM were recruited for this observational cohort in Lagos, Nigeria, using respondent-driven sampling and screened for HIV and bacterial STIs every three months for up to 18 months. Read More

    Asymptomatic urethral lymphogranuloma venereum: a case report.
    Int J STD AIDS 2018 Jan 1:956462417751813. Epub 2018 Jan 1.
    1 Clinique médicale l'Actuel, Montréal, Canada.
    Since 2003, there has been a resurgence of lymphogranuloma venereum (LGV), a variant of Chlamydia trachomatis (CT), among men who have sex with men (MSM) in several urban areas of Europe and North America. LGV infection occurs most often at anal sites causing proctitis. Urethral and oropharyngeal infections are rare. Read More

    The Etiology of Genital Ulcer Disease and Coinfections With Chlamydia trachomatis and Neisseria gonorrhoeae in Zimbabwe: Results From the Zimbabwe STI Etiology Study.
    Sex Transm Dis 2018 Jan;45(1):61-68
    From the *Zimbabwe Ministry of Health and Child Care; †Department of Community Medicine, University of Zimbabwe, College of Health Sciences, Harare, Zimbabwe; ‡US Centers for Disease Control and Prevention, Zimbabwe and Division of Global HIV/AIDS, CDC, Atlanta, GA; §Fogarty International Center, National Institutes of Health, Bethesda, MD; ¶Zimbabwe Community Health Intervention Research (ZiCHIRe) Project, Harare, Zimbabwe; ∥Western Sydney Sexual Health Centre, Parramatta; **Marie Bashir Institute for Infectious Diseases and Biosecurity & Sydney Medical School-Westmead, University of Sydney, Sydney, New South Wales, Australia; ††School of Medicine, University of Washington, Seattle, WA; ‡‡Colorado School of Public Health, University of Colorado Denver, Denver, CO; §§Rietmeijer Consulting LLC, Denver, CO.
    Background: In many countries, sexually transmitted infections (STIs) are treated syndromically. Thus, patients diagnosed as having genital ulcer disease (GUD) in Zimbabwe receive a combination of antimicrobials to treat syphilis, chancroid, lymphogranuloma venereum (LGV), and genital herpes. Periodic studies are necessary to assess the current etiology of GUD and assure the appropriateness of current treatment guidelines. Read More

    Strain Types Have Diversified Regionally and Globally with Evidence for Recombination across Geographic Divides.
    Front Microbiol 2017 13;8:2195. Epub 2017 Nov 13.
    UCSF Benioff Children's Hospital Oakland Research Institute, Oakland, CA, United States.
    () is the leading cause of bacterial sexually transmitted diseases worldwide. The Multi Locus Sequence Typing (MLST) scheme is effective in differentiating strain types (ST), deciphering transmission patterns and treatment failure, and identifying recombinant strains. Here, we analyzed 323 reference and clinical samples, including 58 samples from Russia, an area that has not previously been represented in typing schemes, to expand our knowledge of the global diversification of STs. Read More

    [Diagnostic issues of lymphogranuloma venereum: A case series of 5 patients].
    Rev Med Interne 2017 Dec 8;38(12):794-799. Epub 2017 Nov 8.
    Service de médecine interne, hôpital Ambroise-Paré, AP-HP, 92100 Boulogne-Billancourt, France. Electronic address:
    Introduction: Lymphogranuloma venereum (LG) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis L serovar.

    Methods: These five consecutive cases aim to highlight the risk of LG misdiagnosis, in case of initial presentation with isolated inguinal adenitis.

    Results: Five men (mean age: 30±7 years) were seen in an internal medicine department, for inguinal adenopathy. Read More

    Chlamydia trachomatis Biovar L2 Infection in Women in South Africa.
    Emerg Infect Dis 2017 11;23(11):1913-1915
    We detected Chlamydia trachomatis biovar L2 in vaginal swab specimens of 7 women with vaginal discharge in South Africa. Whole-genome sequencing directly from clinical specimens identified a closely related cluster of strains. The clinical role of this infection in the context of syndromic management should be clarified. Read More

    Lymphogranuloma venereum rates increased and Chlamydia trachomatis genotypes changed among men who have sex with men in Sweden 2004-2016.
    J Med Microbiol 2017 Nov 12;66(11):1684-1687. Epub 2017 Oct 12.
    1​Department of Medical Sciences, Section of Clinical Bacteriology, Uppsala University, Uppsala, Sweden.
    This study aimed to determine the incidence of lymphogranuloma venereum (LGV) in Sweden since 2004 and to study in detail a consecutive number of Chlamydia trachomatis cases in men who have sex with men (MSM) during a 10 month period (September 2014 to July 2015). LGV increased from sporadic import cases in 2004 to comprise a spread within Sweden in 2016. Initially, only the L2b ompA genotype was detected, but in 2015 half of the genotyped LGV cases were L2 genotype. Read More

    Acquisition of wild-type HIV-1 infection in a patient on pre-exposure prophylaxis with high intracellular concentrations of tenofovir diphosphate: a case report.
    Lancet HIV 2017 Nov 14;4(11):e522-e528. Epub 2017 Sep 14.
    Department of Infectious Diseases, Amsterdam Infection and Immunity Institute (AI&II), Academic Medical Center, University of Amsterdam, Netherlands; Department of Global Health and Amsterdam Institute for Global Health and Development, Academic Medical Center, University of Amsterdam, Netherlands.
    Background: Pre-exposure prophylaxis (PrEP) with emtricitabine and tenofovir disoproxil fumarate is highly effective against acquisition of HIV infection, and only two cases of infection with a multidrug-resistant virus have been reported under adequate long-term adherence, as evidenced by tenofovir diphosphate concentrations in dried blood spots. We report a case of wild-type HIV-1 infection despite consistent use of emtricitabine and tenofovir disoproxil fumarate.

    Methods: The patient participated in the Amsterdam PrEP project, a demonstration project of daily and event-driven PrEP. Read More

    Frequency and genotypes of Chlamydia trachomatis in patients attending the obstetrics and gynecology clinics in Jalisco, Mexico and correlation with sociodemographic, behavioral, and biological factors.
    BMC Womens Health 2017 Sep 15;17(1):83. Epub 2017 Sep 15.
    Servicio de Gastroenterología, Hospital Universitario Dr. Jose Eleuterio Gonzalez, Universidad Autónoma de Nuevo León, Av. Gonzalitos and Madero, Mitras Centro PC, 64460, Monterrey, Nuevo León, Mexico.
    Background: Chlamydia trachomatis is the causative agent of the most common bacterial sexually transmitted infection worldwide. The aim of this study was to investigate the frequency and genotypes of C. trachomatis in patients attending an obstetrics and gynecology clinic in Jalisco, Mexico and correlates them with sociodemographic, behavioral, and biological factors. Read More

    Laboratory Processes for Confirmation of Lymphogranuloma Venereum Infection During a 2015 Investigation of a Cluster of Cases in the United States.
    Sex Transm Dis 2017 Nov;44(11):691-694
    From the Division of STD Prevention, CDC, Atlanta, GA.
    In September 2015, the Centers for Disease Control and Prevention were notified of a suspected outbreak investigation of lymphogranuloma venereum (LGV) cases by the Michigan Department of Health and Human Services. The Centers for Disease Control and Prevention offered support with a laboratory-developed polymerase chain reaction test for LGV. This note describes the laboratory workflow and procedures used for the laboratory confirmation of LGV infection. Read More

    A Macaque Model for Rectal Lymphogranuloma Venereum and Non-Lymphogranuloma Venereum Chlamydia trachomatis: Impact on Rectal Simian/Human Immunodeficiency Virus Acquisition.
    Sex Transm Dis 2017 Sep;44(9):551-556
    From the *Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention; †Libra Management Group, ‡Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA; §The DESA group, Columbia, SC; and ¶Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
    Background: Sustained genital tract inflammation caused by sexually transmitted infections (STIs) is known to increase risk of vaginal human immunodeficiency virus (HIV) infections but, to our knowledge, there are no nonhuman primate studies that have evaluated its link to rectal HIV acquisition.

    Methods: Rhesus macaques inoculated with Chlamydia trachomatis (CT) (serovars LGV-L2 and CT-E; n = 7) or saline (n = 7) received up to 20 rectal challenges twice a week of simian/HIV immunodeficiency virus (SHIVSF162p3). SHIV viremia was determined by real-time PCR and Chlamydia infection by APTIMA Combo 2 testing. Read More

    Low Prevalence of Urethral Lymphogranuloma Venereum Infections Among Men Who Have Sex With Men: A Prospective Observational Study, Sexually Transmitted Infection Clinic in Amsterdam, the Netherlands.
    Sex Transm Dis 2017 Sep;44(9):547-550
    From the *Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht; †Public Health Service of Amsterdam, STI Outpatient Clinic, Public Health Laboratory, Department of Infectious Diseases; ‡Amsterdam Infection and Immunity Institute, Academic Medical Centre, University of Amsterdam; and §Department of Dermatology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
    In contrast to anorectal lymphogranuloma venereum (LGV), few urogenital LGV cases are reported in men who have sex with men. Lymphogranuloma venereum was diagnosed in 0.06% (7/12,174) urine samples, and 0. Read More

    Global survey of mRNA levels and decay rates of trachoma and lymphogranuloma venereum biovars.
    Heliyon 2017 Jul 26;3(7):e00364. Epub 2017 Jul 26.
    Reference Laboratory of Bacterial Sexually Transmitted Infections, Department of Infectious Diseases, National Institute of Health, Lisbon, Portugal.
    Interpreting the intricate bacterial transcriptomics implies understanding the dynamic relationship established between transcription and the degradation of transcripts. Here, we performed a comparative overview of gene expression levels and mRNA decay rates for different-biovar (trachoma and lymphogranuloma venereum) strains of the obligate intracellular bacterium . By using RNA-sequencing to measure gene expression levels at mid developmental stage and mRNA decay rates upon rifampicin-based transcription blockage, we observed that: ) 60-70% of the top-50 expressed genes encode proteins with unknown function and proteins involved in "Translation, ribosomal structure and biogenesis" for all strains; ) the expression ranking by genes' functional categories was in general concordant among different-biovar strains; ) the median of the half-life time (t) values of transcripts were 15-17 min, indicating that the degree of transcripts' stability seems to correlate with the bacterial intracellular life-style, as these values are considerably higher than the ones observed in other studies for facultative intracellular and free-living bacteria; ) transcript decay rates were highly heterogeneous within each strain and did not correlate with steady-state expression levels; ) only at very few instances (essentially at gene functional category level) was possible to unveil dissimilarities potentially underlying phenotypic differences between biovars. Read More

    The first case of lymphogranuloma venereum in a woman in East-Central Europe and its multiple co-infections.
    Folia Microbiol (Praha) 2018 Jan 24;63(1):93-95. Epub 2017 Jul 24.
    Department of Dermatovenereology, Second Faculty of Medicine, Charles University and Hospital Bulovka, Budinova 2, 180 81, Prague 8, Czech Republic.
    We are reporting the first case of lymphogranuloma venereum in women in East-Central Europe. A 22-year-old heterosexual woman attended our department of venereology. She complained about a burning sensation in the urethra and vaginal discharge. Read More

    Extra-rectal lymphogranuloma venereum in France: a clinical and molecular study.
    Sex Transm Infect 2018 Feb 11;94(1):3-8. Epub 2017 Jul 11.
    CHU Bordeaux, Service des Maladies Infectieuses et Tropicales, F-33000 Bordeaux, France.
    Objectives: To describe a series of extrarectal lymphogranuloma venereum (LGV) cases diagnosed in France.

    Methods: Consecutive LGV cases confirmed at the French Reference Centre for chlamydiae with an extrarectal sample from January 2010 to December 2015 were included. The first part of the study consisted of a retrospective case note review and analysis. Read More

    proctitis masquerading as carcinoma rectum: First case report from India.
    Indian J Pathol Microbiol 2017 Apr-Jun;60(2):259-261
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    While proctitis is caused both by infectious and noninfectious causes, infectious causes are acquired typically sexually. Chlamydia trachomatis, which is the most frequent bacterial pathogen causing sexually transmitted infections worldwide, is one of the causative agents of proctitis. We report a case history of a bisexual male who presented to us with rectal bleeding. Read More

    Inguinal and anorectal Lymphogranuloma Venereum: a case series from a sexually transmitted disease center in Rome, Italy.
    BMC Infect Dis 2017 06 2;17(1):386. Epub 2017 Jun 2.
    Clinic of Dermatology and Infectious Diseases (STI/HIV Unit), San Gallicano Dermatological Institute (IFO-IRCCS), Rome, Italy.
    Background: Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by L1, L2, L3 serovars of C. trachomatis (CT). Since 2003, LGV cases have been increasing in Europe. Read More

    Rapid detection and strain typing of Chlamydia trachomatis using a highly multiplexed microfluidic PCR assay.
    PLoS One 2017 31;12(5):e0178653. Epub 2017 May 31.
    NetBio, Waltham, Massachusetts, United States of America.
    Nucleic acid amplification tests (NAATs) are recommended by the CDC for detection of Chlamydia trachomatis (Ct) urogenital infections. Current commercial NAATs require technical expertise and sophisticated laboratory infrastructure, are time-consuming and expensive, and do not differentiate the lymphogranuloma venereum (LGV) strains that require a longer duration of treatment than non-LGV strains. The multiplexed microfluidic PCR-based assay presented in this work simultaneously interrogates 13 loci to detect Ct and identify LGV and non-LGV strain-types. Read More

    Lymphogranuloma Venereum-Serovar L2b Presenting With Painful Genital Ulceration: An Emerging Clinical Presentation?
    Sex Transm Dis 2017 05;44(5):310-312
    From the *Dermatologie et Vénéréologie, Hopital Saint Louis, Universités Bobigny, Paris, France; †Dermatologie et Vénéréologie, Hopital Hammoud, Beyrouth, Liban; ‡Centre National de Référence des Chlamydiae et des Mycoplasma, Université de Bordeaux, Bordeaux ; and §Dermatologie et Vénéréologie, Hopital Saint Louis, Paris, France.
    These 5 cases of atypical inflammatory lymphogranula venereum (LGV) serovar L2b presenting initially with edema and persistent painful ulceration illustrate that clinical manifestations of LGV in the current outbreak in men who have sex with men reflect the influence of both the serovars virulence and the host immune system and are not confined to proctitis. L2b serovar could have a particular high virulence profile, and the need for awareness of LGV as a cause of genital ulceration is crucial. Read More

    Skin diseases of the vulva: Infectious diseases.
    J Obstet Gynaecol 2017 Oct 11;37(7):840-848. Epub 2017 Apr 11.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area. Read More

    Treatment Outcomes for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men Using Doxycycline, Azithromycin, or Both: A Review of Clinical Cases.
    Sex Transm Dis 2017 04;44(4):245-248
    From the *Melbourne Sexual Health Centre, Alfred Health, Carlton, Melbourne, Victoria, Australia; †Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; ‡Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne; §Microbiological Diagnostic Unit Public Health Laboratory, University of Melbourne, Parkville; and ¶Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
    Background: Treatment for rectal lymphogranuloma venereum where doxycycline 100 mg twice daily for 21 days was used-either alone or together with azithromycin 1 g single dose-resulted in microbiological cure of 97%. These data support doxycycline 100 mg twice daily for 21 days as the preferred treatment for rectal lymphogranuloma venereum. Read More

    Comparison of Murine Cervicovaginal Infection by Chlamydial Strains: Identification of Extrusions Shed .
    Front Cell Infect Microbiol 2017 3;7:18. Epub 2017 Feb 3.
    Department of Microbiology and Molecular Genetics, Oklahoma State University Stillwater, OK, USA.
    is the leading cause of bacterial sexually transmitted infections (STIs) and preventable blindness. Untreated, asymptomatic infection as well as frequent re-infection are common and may drive pelvic inflammatory disease, ectopic pregnancy, and infertility. models of chlamydial infection continue to be instrumental in progress toward a vaccine and further elucidating the pathogenesis of this intracellular bacterium, however significant gaps in our understanding remain. Read More

    Delayed diagnosis of lymphogranuloma venereum-associated colitis in a man first suspected to have rectal cancer.
    JRSM Open 2016 Jan 1;8(1):2054270416660933. Epub 2016 Dec 1.
    St George's Hospital, Tooting, London SW17 0QT, UK.
    Lymphogranuloma venereum-associated colitis is a diagnosis that should not be missed. The following case represents the importance of a thorough history, including the importance of the sexual history to prevent the misdiagnosis of these patients. Read More

    Co-infection by lymphogranuloma venereum and Haemophilus parainfluenzae during an episode of proctitis.
    Gastroenterol Hepatol 2018 02 10;41(2):107-109. Epub 2017 Feb 10.
    Servicio de Microbiología, Complejo Hospitalario Universitario de Granada-ibsGranada, Granada, España; Departamento de Microbiología, Universidad de Granada-ibsGranada, Granada, España. Electronic address:

    Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016.
    Euro Surveill 2017 Feb;22(5)
    Department of Phage and Molecular Typing, National Centre for Epidemiology, Budapest, Hungary.
    In eastern Europe, few countries have so far reported laboratory-confirmed cases of lymphogranuloma venereum (LGV). Here we describe 22 LGV cases in men who have sex with men (MSM) detected in Hungary from November 2012 to July 2016. Sequence analyses show that 16 of these 22 cases were affected by the L2c genovariant, with from 2012 to 2014, one LGV L2c case detected per year, followed by seven cases in 2015 and six up to July 2016. Read More

    Granulomatous & histiocytic dermatitides.
    Semin Diagn Pathol 2017 May 14;34(3):301-311. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical & Cytological Pathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:
    Granulomas of the skin may be classified in several ways. They are either infectious or non-infectious in character, and they contain areas of necrobiosis or necrosis, or not. Responsible infectious agents may be mycobacterial, fungal, treponemal, or parasitic organisms, and each case of granulomatous dermatitis should be assessed histochemically for those microbes. Read More

    [Reactive arthritis associated with Chlamydia trachomatis genovar L2b proctitis].
    Med Mal Infect 2017 Mar 10;47(2):177-178. Epub 2016 Dec 10.
    Service des maladies infectieuses et tropicales, hôpital Pellegrin, centre hospitalier universitaire de Bordeaux, place Amélie Raba-Léon, 33076 Bordeaux cedex, France; USC EA 3671, infections humaines à mycoplasmes et chlamydiae, université de Bordeaux, 33000 Bordeaux, France; Inra, USC EA 3671, infections humaines à mycoplasmes et chlamydiae, 33000 Bordeaux, France.

    Protection against genital tract Chlamydia trachomatis infection following intranasal immunization with a novel recombinant MOMP VS2/4 antigen.
    APMIS 2016 Dec;124(12):1078-1086
    Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    The asymptomatic nature of most Chlamydia trachomatis infections and the lack of appropriate effects by current prevention and management call for vaccine development. We evaluated a recombinant subunit vaccine candidate based on the major outer membrane protein variable segments 2 and 4 (MOMP VS2/4). To achieve maximal immunogenicity and ease of production and purification, MOMP VS2/4 was constructed by using highly immunogenic sequences of MOMP only, thereby minimizing the presence of hydrophobic regions, and spacing the immunogenic epitopes with a flexible amino acid sequence. Read More

    The need to scale up HIV indicator condition-guided testing for early case-finding: a case-control study in primary care.
    BMC Fam Pract 2016 11 17;17(1):161. Epub 2016 Nov 17.
    National Institute for Public Health and the Environment (RIVM), Epidemiology & Surveillance Unit, Centre for Infectious Disease Control, Bilthoven, The Netherlands.
    Background: European guidelines recommend offering an HIV test to individuals who display HIV indicator conditions (ICs). We aimed to investigate the incidence of ICs in primary care reported in medical records prior to HIV diagnosis.

    Methods: We did a cross-sectional search in an electronic general practice database using a matched case-control design to identify which predefined ICs registered by Dutch GPs were most associated with an HIV-positive status prior to the time of diagnosis. Read More

    Impact of rapid diagnostic testing for chlamydia and gonorrhea on appropriate antimicrobial utilization in the emergency department.
    Diagn Microbiol Infect Dis 2017 Feb 18;87(2):175-179. Epub 2016 Oct 18.
    Department of Infectious Diseases, Mercy Health Saint Mary's, Grand Rapids, MI 49503, USA.
    Prolonged turnaround time of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) test results may delay time to notification and treatment of test-positive patients and result in unnecessary antimicrobial use in test-negative patients. This quasi-experimental study evaluated the impact of NG/CT rapid diagnostic testing (RDT) in an urban emergency department (ED) on treatment appropriateness, time to notification, and cost. Patients tested in December 2013-January 2014 (traditional group, n=200) were compared with those in December 2014-January 2015 (RDT group, n=200). Read More

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