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Am J Med 2020 Jul;133(7):e391

Department of Internal Medicine, Hospital Universitario y Politécnico La Fe València, Spain. Electronic address:

Rev Esp Quimioter 2020 Jun 12. Epub 2020 Jun 12.

Inés Olaya García Rodríguez, Servicio de Microbiología y Control de la Infección. Hospital Universitario de Canarias. Crtra Ofra s/n. 38320. La Cuesta. La Laguna. Spain.

PLoS One 2020 4;15(6):e0233990. Epub 2020 Jun 4.

Public Health Laboratory (GGD) Amsterdam, Department of infectious diseases, Amsterdam, The Netherlands.

Objectives: Typing of Chlamydia trachomatis (CT) is traditionally performed by characterising the ompA gene, resulting in more than a dozen different genovars, A to L. Type L is associated with Lymphogranuloma venereum (LGV) and commonly screened for using PCR, targeting the chromosomal pmpH gene. We aimed to develop and validate a new CT/LGV plasmid-based typing assay targeting the pgp3 gene, to increase sensitivity and thus reduce the number of non-typeable results. Read More

Indian J Med Microbiol 2019 Oct-Dec;37(4):595-597

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

N Engl J Med 2020 05;382(21):2023-2032

From the Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, and the Department of Microbiology, Royal Melbourne Hospital (D.A.W.), and Melbourne Sexual Health Centre, Alfred Health, and Central Clinical School, Monash University (M.Y.C.) - all in Melbourne, VIC, Australia.

J Infect Chemother 2020 Jul 5;26(7):762-764. Epub 2020 May 5.

Department of Laboratory Medicine, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.

Acute inguinal lymphadenitis is usually caused by lower extremity infection and sexually transmitted diseases, such as chancroid, lymphogranuloma venereum, genital herpes, or syphilis. Yersinia pseudotuberculosis is a non-spore forming, pleomorphic, non-lactose fermenting Gram negative bacillus and a member of the family Enterobacteriaceae, which is associated with diarrheal diseases. It also causes mesenteric lymphadenitis at the terminal ileum, which can be clinically indistinguishable from acute appendicitis (pseudoappendicitis). Read More

N Engl J Med 2020 Apr;382(17):1638

Griffin Hospital, Derby, CT

Sex Transm Infect 2020 Apr 17. Epub 2020 Apr 17.

Univ. Bordeaux, USC EA3671, Mycoplasmal and Chlamydial Infections in Humans, Bordeaux, France.

Objectives: We evaluated the prevalence of lymphogranuloma venereum (LGV) in anorectal -positive French men who have sex with men (MSM) using pre-exposure prophylaxis (PrEP) for HIV. Here, we describe the clinical, biological and behavioural characteristics of these patients.

Methods: Laboratories throughout French metropolitan areas performing routine testing for sent positive anorectal specimens to the National Reference Centre for bacterial STIs for LGV real-time PCR targeting the H gene. Read More

Euro Surveill 2020 Apr;25(14)

Centre of Infectious Disease Control, National Institute for Public Health and Environment, Bilthoven, the Netherlands.

IntroductionLymphogranuloma venereum (LGV), an invasive form of infection, has been reported among (mainly HIV-positive) men who have sex with men (MSM) since 2003. In the Netherlands, LGV testing recommendations changed from selective to universal testing in 2015. Changes in tested populations could have led to incomparable LGV positivity rates over time. Read More

J Eur Acad Dermatol Venereol 2020 Mar 17. Epub 2020 Mar 17.

Sexually Transmitted Infections Unit Vall d'Hebron-Drassanes, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain.

Hautarzt 2020 Apr;71(4):275-283

Klinik für Dermatologie und Venerologie, Universitätsklinikum Essen, Essen, Deutschland.

Background: Sexually transmitted infections (STIs) in the anorectal region are disproportionally detected in risk populations such as men who have sex with men (MSM). However, due to changes in sexual behaviour they are increasingly diagnosed in heterosexual individuals. Due to the recent implementation of oral HIV pre-exposure prophylaxis together with lack of condom use, a further rise in STIs is expected. Read More

Sex Transm Dis 2020 Apr;47(4):253

University of Washington Center for AIDS and STD Seattle, WA Northern Health & Social Care Trust Antrim, Northern Ireland, UK.

Sex Transm Infect 2020 Jan 30. Epub 2020 Jan 30.

The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.

Objectives: We explored the association between nucleic acid amplification testing (NAAT) and rectal microscopy/proctoscopy findings and correlates of rectal STIs among 150 gay and bisexual men (GBM) diagnosed with proctitis at the Sydney Sexual Health Centre from March 2016 to October 2017.

Methods: From case files, we analysed risk behaviours, microscopy, proctoscopy and NAAT results for rectal STIs (, , , herpes simplex virus type 1/2, lymphogranuloma venereum and syphilis). χ test assessed the association between microscopy/proctoscopy findings and NAAT results. Read More

Sex Transm Dis 2020 02;47(2):114-121

From the Department of Infectious Diseases, Public Health Service of Amsterdam.

Objectives: Male and transgender women sex workers (TSWs) are vulnerable for sexually transmitted infections (STIs) and human immunodeficiency virus (HIV), and substance use might be a relevant contributing factor. We assessed sociodemographic characteristics and substance use among sex workers; divided into 3 groups: Transgender women sex workers, male sex workers who have sex with men only or also with females (MSW-M), male sex workers who have sex with females only (MSW-F).

Methods: A survey on substance use and sexual (risk) behavior was offered during routine STI screening at the Prostitution and Health Centre (P&G292) in Amsterdam. Read More

Rev Esp Quimioter 2020 Feb 2;33(1):76-77. Epub 2020 Jan 2.

Berta Pino Calm, Unidad de Microbiología y Parasitología. Servicio de Análisis Clínicos, Hospital Universitario Nuestra Señora de Candelaria. Ctra. del Rosario, 145, 38010 Santa Cruz de Tenerife. Spain.

Sex Transm Dis 2020 Mar;47(3):162-164

From the Unidad Clínica de Enfermedades Infecciosas y MicrobiologÍa (UCEIM), Valme University Hospital.

Background: The early identification of the Chlamydia trachomatis variants that cause lymphogranuloma venereum (LGV) is very important to establish an adequate antibiotic treatment. This identification should be made with molecular techniques that are easy to perform and accessible to most microbiology laboratories. The objective of this study was to evaluate 2 real-time polymerase chain reaction (PCR)-based assay (VIASURE Haemophilus ducreyi + C. Read More

Eur J Gastroenterol Hepatol 2020 Mar;32(3):454-457

Department of Systems Medicine, Unit of Gastroenterology, University 'Tor Vergata' of Rome.

Infectious proctitis may mimic inflammatory bowel disease, particularly when limited to the rectum. The present case report includes findings from a 50-year-old man, soldier, referring to our Inflammatory Bowel Disease Unit with a diagnosis of rectal Crohn's disease, refractory to conventional treatments. Mild anemia, hypergammaglobulinemia and HIV-antibodies seronegativity were detected. Read More

Clin Gastroenterol Hepatol 2019 Dec 13. Epub 2019 Dec 13.

Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

BMC Infect Dis 2019 Dec 10;19(1):1041. Epub 2019 Dec 10.

Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, China.

Background: Chlamydia trachomatis (CT) infection is one of the most pervasive sexually transmitted infections and has high prevalence in urogenital and extra-urogenital sites among men who have sex with men (MSM). This study investigated anatomical site-specific prevalence and genotypes of CT among MSM recruited from three geographic areas in China.

Methods: We collected urine specimens and anorectal, pharyngeal swab specimens from 379 MSM. Read More

Sci Rep 2019 12 4;9(1):18327. Epub 2019 Dec 4.

Institute for Hygiene and Applied Immunology, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Infection of humans with Chlamydia trachomatis, a bacterial pathogen with a unique intracellular replication cycle, may cause a variety of clinical manifestations. These are linked to various serovars of the pathogen; trachoma to serovars A-C, oculogenital infections to serovars D-K, and lymphogranuloma venereum to serovars L1-L3. Nineteen serovars are known as human pathogens. Read More

J Travel Med 2019 Dec;26(8)

Sorbonne Université, AP-HP, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Service de Maladies Infectieuses et Tropicales, Department of Infectious and Tropical Diseases, Paris 75013, France.

Background: The incidence of sexually transmitted infections (STI) is increasing in Western countries whilst travel plays a major role in STI dissemination worldwide. However, there is no study distinguishing HIV-positive and HIV-negative travellers.

Methods: We retrospectively evaluated the epidemiological, clinical and biological characteristics of the patients diagnosed with a travel-related STI between 2008 and 2016. Read More

Int J STD AIDS 2019 12 22;30(14):1446-1449. Epub 2019 Nov 22.

Sydney Sexual Health Centre, South Eastern Sydney Local Health District, Sydney, Australia.

Curr Rheumatol Rep 2019 11 19;21(11):63. Epub 2019 Nov 19.

School of Medicine, Wayne State University, Detroit, MI, USA.

Purpose Of Review: Recent studies regarding the frequency of Chlamydia-induced reactive arthritis (ReA) are reviewed, with a focus on the question of whether the entity is in fact disappearing or whether it is simply being underdiagnosed/underreported. Epidemiological reports indicate diversity in the frequency of Chlamydia-associated ReA in various parts of the world, with evidence of declining incidence in some regions.

Recent Findings: The hypothesis that early effective treatment with antibiotics prevents the manifestation of Chlamydia-associated ReA requires further investigation. Read More

Commun Dis Intell (2018) 2019 Nov 18;43. Epub 2019 Nov 18.

Communicable Diseases Branch, Health Protection NSW, NSW Health, North Sydney, New South Wales.

Aim: To describe the epidemiology of lymphogranuloma venereum (LGV) in New South Wales (NSW) from 2006 to 2015.

Methods: LGV notification data between 2006 and 2015 from New South Wales were analysed to describe time trends in counts and rates by gender, age group and area of residence, as well as anatomical sites of infection. A positivity ratio was calculated using the number of LGV notifications per 100 anorectal chlamydia notifications per year. Read More

Microb Genom 2019 11;5(11)

Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health, Lisbon, Portugal.

is the most prevalent sexually transmitted bacterium worldwide and the causative agent of trachoma. Its strains are classified according to their genotypes, which are strongly linked to differential tissue tropism and disease outcomes [ocular disease, urogenital disease and lymphogranuloma venereum (LGV)]. While the genome-based species phylogenetic tree presents four main clades correlating with tropism/prevalence, namely ocular, LGV, urogenital T1 (more prevalent genotypes) and urogenital T2 (less prevalent genotypes), inter-clade exchange of is considered a rare phenomenon probably mediating marked tropism alterations. Read More

Emerg Infect Dis 2019 11;25(11):2112-2114

Orolabial lymphogranuloma venereum was diagnosed for a man in Michigan, USA, who had sex with men, some infected with HIV. High index of suspicion for lymphogranuloma venereum led to accurate diagnosis, successful therapy, and description of an L2b variant with a unique genetic mutation. Read More

Clin Colon Rectal Surg 2019 Sep 22;32(5):358-363. Epub 2019 Aug 22.

Division of Colon and Rectal Surgery, Keck School of Medicine at the University of Southern California, Los Angeles, California.

This article provides a practical overview for the management of nonviral sexually transmitted diseases affecting the perianal and anorectal regions. Clinical manifestations, diagnosis, and treatment of syphilis, gonorrhea, chancroid, donovanosis, and lymphogranuloma venereum are individually addressed. Read More

J Int AIDS Soc 2019 08;22 Suppl 6:e25347

STI Outpatient Clinic, Infectious Diseases Department, Public Health Service (GGD) Amsterdam, Amsterdam, The Netherlands.

World J Clin Cases 2019 Jul;7(14):1795-1804

Evidence and Value Generation, Global Medical Affairs, Takeda Pharmaceuticals International Inc., Deerfield, IL 6001, United States.

Background: Anal fistula is a pathological connection between the anal canal and perianal skin, which most commonly develops from an infected anal crypt. While the majority of anal fistulas are idiopathic, they are also associated with Crohn's disease (CD) and other inflammatory conditions. The prevalence of anal fistula is estimated to be 1-2 per 10000 patients, but population-based studies on anal fistula epidemiology are limited and outdated. Read More

Sex Transm Dis 2019 10;46(10):689-692

From the Infectious Diseases Unit, Hospital General Universitario Gregorio Marañón.

Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by invasive serovars of Chlamydia trachomatis. There have been only a few case reports of oropharyngeal C. trachomatis infection complicated with cervical LGV. Read More

J Cutan Med Surg 2019 Nov/Dec;23(6):624-634. Epub 2019 Jun 28.

Division of Dermatology, Department of Medicine, Women's College Hospital, University of Toronto, ON, Canada.

Genital ulcer disease can be caused by a wide variety of sources. Most commonly, genital ulcer disease is grouped into infectious and noninfectious causes. HSV, syphilis, lymphogranuloma venereum, and chancroid represent some common infectious ulcers. Read More

J Eur Acad Dermatol Venereol 2019 Oct 26;33(10):1821-1828. Epub 2019 Jun 26.

WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

New or important issues in this updated version of the 2013 European guideline on the management of lymphogranuloma venereum (LGV): EPIDEMIOLOGY: Lymphogranuloma venereum continues to be endemic among European men who have sex with men (MSM) since 2003. Lymphogranuloma venereum infections in heterosexuals are extremely rare in Europe, and there is no evidence of transmission of LGV in the European heterosexual population.

Aetiology And Transmission: Chlamydia trachomatis serovars/genovars L2b and L2 are the causative strains in the majority of cases in Europe. Read More

Sex Transm Infect 2020 03 23;96(2):137-142. Epub 2019 Jun 23.

National Infection Service, Public Health England, London, UK.

Objectives: Understanding the public health impact of lymphogranuloma venereum (LGV) in Europe is hampered by inadequate diagnostics and surveillance systems in many European countries. We developed and piloted LGV surveillance in three European countries without existing systems and performed a preliminary investigation of LGV epidemiology, where little evidence currently exists.

Methods: We recruited STI or dermatovenereology clinics and associated laboratories serving men who have sex with men (MSM) in Austria, Croatia and Slovenia, using the UK for comparison. Read More

Int J STD AIDS 2019 07 2;30(8):732-738. Epub 2019 May 2.

2 Microbiology, DIMES, University of Bologna, Bologna, Italy.

mBio 2019 04 9;10(2). Epub 2019 Apr 9.

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA

Interferon-regulated immune defenses protect mammals from pathogenically diverse obligate intracellular bacterial pathogens of the genus Interferon gamma (IFN-γ) is especially important in controlling the virulence of species and thus impacts the modeling of human chlamydial infection and disease in mice. How IFN-γ contributes to cell-autonomous defenses against species and how these pathogens evade IFN-γ-mediated immunity in their natural hosts are not well understood. We conducted a genetic screen which identified 31 -ensitive (Igs) mutants of the mouse model pathogen Genetic suppressor analysis and lateral gene transfer were used to map the phenotype of one of these mutants, Igs4, to a missense mutation in a putative chlamydial inclusion membrane protein, TC0574. Read More

Emerg Med Clin North Am 2019 May;37(2):165-192

Prisma Health, University of South Carolina School of Medicine Greenville, 701 Grove Road, Greenville, SC 29605, USA. Electronic address:

Sexually transmitted diseases (STDs) continue to be underrecognized leading to devastating health and economic consequences. Emergency clinicians play an important role in diagnosing and managing STDs and in improving health care outcomes for both the patient and their partners. In addition, antibiotic resistance and emerging infections continue to challenge providers in clinical practice. Read More

J Dtsch Dermatol Ges 2019 Mar;17(3):287-315

WIR "Walk In Ruhr", competence network HIV/AIDS, Center for Sexual Health and Medicine, Department of Dermatology, Venereology and Allergology, Ruhr University, Bochum, Germany.

Worldwide, the incidence of bacterial sexually transmitted infections (STIs) has shown a significant increase in recent years. In Germany, this circumstance is reflected by a rise in the number of reported syphilis cases. There has also been an uptick in the incidence of non-notifiable STIs such as gonorrhea and infections caused by Chlamydia trachomatis and Mycoplasma genitalium. Read More

J Dtsch Dermatol Ges 2019 Mar;17(3):287-317

WIR "Walk In Ruhr", Kompetenznetz HIV/AIDS, Zentrum für Sexuelle Gesundheit und Medizin, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr-Universität Bochum.

Bakterielle sexuell übertragbare Infektionen (STI) zeigen seit Jahren weltweit eine deutliche Zunahme. In Deutschland wird diese Tatsache durch steigende Meldezahlen für Syphilis bestätigt. Auch für die nicht meldepflichtigen STI Gonorrhoe, Chlamydia-trachomatis- und Mycoplasma-genitalium-Infektionen wird eine zunehmende Inzidenz beobachtet. Read More

Radiol Case Rep 2019 May 5;14(5):581-583. Epub 2019 Mar 5.

UC San Diego Health, CA, USA.

Lymphogranuloma venereum is a sexually transmitted infection caused by serovars L1, L2, and L3 of . We here report a case of Lymphogranuloma venereum, confirmed by PCR testing, which mimicked malignancy on CT imaging. Read More

Enferm Infecc Microbiol Clin 2019 Oct 14;37(8):525-534. Epub 2019 Mar 14.

Unidad de ITS Vall d'Hebron-Drassanes, Servicio de Enfermedades Infecciosas, Hospital Vall d'Hebron, Barcelona, España.

Sexually transmitted infections caused by Chlamydia trachomatis, including lymphogranuloma venereum and Mycoplasma genitalium have increased in last decade. This epidemiological scenario presents new challenges in order to improve and strengthen our control and prevention strategies. The routine clinical diagnosis of urethritis and cervicitis must be combined with the active search for the causal agent in men with symptoms of dysuria or proctitis, and in women with pelvic inflammatory disease. Read More

Radiol Case Rep 2018 Dec 13;13(6):1119-1122. Epub 2018 Sep 13.

Division of Gastroenterology, Department of Medicine, Duke University Medical Center, 2400 Pratt Street, Suite 8007, Durham, NC 27710, USA.

Lymphogranuloma venereum is a sexually transmitted infection caused by serotypes L1-3 of and may present as hemorrhagic proctocolitis. The diagnosis of an active infection is difficult to establish, as confirmatory testing can be unreliable or unavailable. Imaging findings can be nonspecific and mimic malignancy or other chronic infectious and inflammatory disorders. Read More

Emerg Infect Dis 2019 03;25(3):598-599

Among 34 men with proctitis in Buenos Aires, Argentina, 16 (47%) had Chlamydia trachomatis infection, 11 (68.8%) of which were biovar lymphogranuloma venereum. The outbreak was probably local, as in Europe. Read More

Euro Surveill 2019 Jan;24(5)

Santé publique France (the French national public health agency), Saint-Maurice, France.

Diagnoses of bacterial sexually transmitted infections (STI) have been increasing in France since their resurgence in the late 1990s. This article presents recent epidemiological trends until 2016 and the patients' characteristics. STI surveillance relies on sentinel networks: a clinician-based network RésIST (clinical, biological and behavioural data for early syphilis and gonorrhoea), the lymphogranuloma venereum (LGV) network (clinical, biological and behavioural data for rectal LGV, and the laboratory networks Rénachla and Rénago (demographic and biological data for chlamydial infections and gonorrhoea, respectively). Read More

Int J STD AIDS 2019 04 4;30(5):515-518. Epub 2019 Feb 4.

3 RPA Sexual Health, Sydney Local Health District, Camperdown, Australia.

An epidemic of lymphogranuloma venereum among men who have sex with men (MSM) has persisted in Australia for over a decade and virtually all diagnoses are made from rectal samples. We discuss two cases of human immunodeficiency virus-negative MSM who presented with a penile ulcer. The diagnosis can be made by ensuring a swab of any such ulcer is tested for Chlamydia trachomatis. Read More