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Dermatol Ther 2022 Apr 12;35(4):e15347. Epub 2022 Feb 12.

Department of Dermatology, Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Am J Dermatopathol 2022 Mar;44(3):226-229

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX; and.

Abstract: Cutaneous lymphoid hyperplasia (CLH) is a benign reactive process with T-cell or B-cell lymphocytic infiltration in the skin, which can simulate cutaneous lymphomas both clinically and histologically. Various antigenic stimuli have been implicated in the development of CLH, including tick bites. Finding histologic evidence of such triggering factors, however, is often difficult. Read More

Am J Dermatopathol 2022 May;44(5):338-347

Dermatologikum Hamburg, Hamburg, Germany; and.

Abstract: Lyme borreliosis (LB) is the most common tick-borne infection in Europe and North America. Polymerase chain reaction (PCR) is an important tool to confirm the diagnosis, but not always successful, especially when organisms are sparse. We developed a novel, seminested real-time PCR assay [target: 5S-23S intergenic spacer region (IGS)] and compared it with 3 well-established conventional PCR assays (IGS/OspA/real-time IGS) on 596 formalin-fixed, paraffin-embedded routine skin biopsies. Read More

Histopathology 2022 Jan;80(1):184-195

Department of Dermatology and Allergology, University Hospitals Schleswig-Holstein, Christian-Albrecht-University, Kiel, Germany.

This review focuses upon the pragmatic diagnostic approach of suspicious B cell infiltrations in the skin and lists the necessary histopathological and molecular tools for a thorough work-up. We start with the description of different histopathological patterns of cutaneous B cell infiltrations and recommend pattern-dependent immunohistochemical staining algorithms for further differential diagnosis. A summarised description of the current World Health Organisation (WHO) subtypes of primary cutaneous B cell lymphomas highlighting their most relevant clinical, histopathological and molecular features is included. Read More

Dermatol Online J 2021 Sep 15;27(9). Epub 2021 Sep 15.

Department of Dermatology, Mayo Clinic, Scottsdale, AZ.

Cutaneous B cell pseudolymphoma (CBPL), or cutaneous lymphoid hyperplasia, is the most common pseudolymphoma. It typically responds well to local treatment and follows a benign course. Herein, we describe the unique case of a patient with CBPL that was refractory to a variety of treatments, with subsequent response to rituximab followed by methotrexate. Read More

J Cutan Pathol 2022 Apr 17;49(4):363-368. Epub 2021 Nov 17.

Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.

Ibrutinib is a Bruton tyrosine kinase inhibitor used to treat many hematologic conditions, most commonly B-cell lymphomas and leukemias. Reportedly, skin rash is an adverse event in up to 27% of treated patients. Histopathologic description of these lesions is limited. Read More

J Dermatol 2022 Feb 29;49(2):e55-e56. Epub 2021 Oct 29.

Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.

J Am Acad Dermatol 2022 04 23;86(4):774-781. Epub 2021 Oct 23.

Institute of Dermatology, Department of Medicine, University of Udine, Udine, Italy.

Background: Limited data on dermatoscopy of nodular/plaque-type T-/B-cell primary cutaneous lymphomas (PCLs) is available.

Objective: To describe dermatoscopic features of nodular/plaque-type PCLs, comparing them with those of clinical mimickers (pseudolymphomas, tumors, and inflammatory lesions) and investigating possible differences according to histologic subtypes.

Methods: Participants were invited to join this retrospective, multicenter case-control study by submitting histologically/immunohistochemically confirmed instances of nodular/plaque-type PCLs and controls. Read More

J Cutan Pathol 2022 Mar 5;49(3):288-292. Epub 2021 Nov 5.

Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA.

Syphilis is a sexually transmitted infectious disease caused by the bacterium Treponema pallidum and can cause a wide variety of cutaneous manifestations, most commonly, a papulosquamous eruption of the trunk and extremities. Treatment with penicillin is curative. We report a case of a 69-year-old man who presented with recent onset of blurry vision and a nonpainful, nonpruritic eruption of pink-to-violaceous dermal nodules on his upper trunk and upper extremities. Read More

Int J Dermatol 2022 Mar 19;61(3):316-323. Epub 2021 Sep 19.

División de Investigación Médica, UMAE Hospital de Pediatría CMNO, IMSS, Guadalajara, Jalisco, México.

Background: Lymphocytoma cutis (LC) is a benign reactive lymphoproliferative B-cell process. It has two variants: localized type with solitary lesions and miliarial type with numerous lesions. The objective was to investigate the characteristics of LC with emphasis on the miliarial type. Read More

J Dermatol 2022 Feb 17;49(2):e48-e49. Epub 2021 Sep 17.

Department of Dermatology, Kido Hospital, Niigata, Japan.

JAAD Case Rep 2021 Oct 8;16:9-11. Epub 2021 Aug 8.

Department of Plastic and Reconstructive Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Skin Res Technol 2022 Jan 29;28(1):176-179. Epub 2021 Aug 29.

Department of Pathology, Faculty of Medicine, Hospital Clínico Universidad de Chile, Universidad de Chile, Santiago, Chile.

Cutaneous pseudolymphomas are reactive lymphoproliferations. The most frequent type is nodular pseudolymphoma, and to date, their ultrasonographic appearance has not been reported. We reviewed the ultrasound images of histologically confirmed nodular types of pseudolymphomas studied with 18 and 71 MHz linear probes. Read More

Dermatopathology (Basel) 2021 Aug 14;8(3):376-389. Epub 2021 Aug 14.

Department of Pathology, Hôpital Necker-Enfants Malades, APHP, 75015 Paris, France.

The term "pseudomalignancy" covers a large, heterogenous group of diseases characterized by a benign cellular proliferation, hyperplasia, or infiltrate that resembles a true malignancy clinically or histologically. Here, we (i) provide a non-exhaustive review of several inflammatory skin diseases and benign skin proliferations that can mimic a malignant neoplasm in children, (ii) give pathologists some helpful clues to guide their diagnosis, and (iii) highlight pitfalls to be avoided. The observation of clinical-pathological correlations is often important in this situation and can sometimes be the only means (along with careful monitoring of the disease's clinical course) of reaching a firm diagnosis. Read More

J Eur Acad Dermatol Venereol 2021 Dec 16;35(12):e905-e906. Epub 2021 Aug 16.

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Am J Dermatopathol 2021 Aug;43(8):543-553

Pathologist, Pathology Department, Hospital University German Trias I Pujol, Barcelona, Spain.

Importance: Reactions to tattoo may simulate common dermatosis or skin neoplasms. Histopathology allows diagnosis and helps determining the level and degree of inflammation associated, consequently orientating treatment.

Objective: To describe the histological features found in biopsies of cutaneous reactions to tattoo. Read More

J Dermatol 2022 Feb 14;49(2):246-252. Epub 2021 Jul 14.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

To identify clonal neoplastic cells in skin affected by B-cell lymphoma using skin flow cytometry (FCM) techniques, we investigated light-chain restriction using skin FCM with clonality assessed by polymerase chain reaction and light-chain restriction by in situ hybridization (ISH). We retrospectively analyzed 16 cases of B-cell lymphoma with cutaneous involvement: primary cutaneous diffuse large B-cell lymphoma, leg type (pcDLBCL-LT) (n = 7), DLBCL-not otherwise specified (DLBCL-NOS) (n = 6), primary cutaneous follicle center lymphoma (pcFCL) (n = 1), and follicular lymphoma (n = 2), as well as cutaneous B-cell pseudolymphoma (n = 9). Results of skin FCM light-chain restriction analyses were compared with immunoglobulin H (IgH) gene rearrangement and κ/λ ISH findings. Read More

Caspian J Intern Med 2021 Apr;12(3):283-289

Department of pathology, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Cutaneous pseudolymphoma can histologically and clinically simulate various types of cutaneous lymphoma. We conducted the current study to evaluate the clinicopathological and immunohistochemical (IHC) aspects of cutaneous pseudolymphoma (PSL).

Methods: 30 cases of cutaneous PSL were selected from the archives of 2013-2017 in Shahid Faghihi Hospital pathology lab, Shiraz University of Medical Sciences. Read More

Ann Dermatol Venereol 2022 Mar 1;149(1):61-63. Epub 2021 Jul 1.

Pediatric dermatology unit, departments of dermatology & venereology and pediatrics, university hospital Lausanne, university of Lausanne, 1011 Lausanne, Switzerland.

SAGE Open Med Case Rep 2021 14;9:2050313X211025104. Epub 2021 Jun 14.

Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

Lymphocytoma cutis reflects an exaggerated local immunologic reaction to a stimulus presenting on the head, neck, or upper extremities as a firm 1-3 cm erythematous and/or violaceous plaque or nodule. However, lymphocytoma cutis may be difficult to treat due to the variety of causative agents and the lack of reported successful treatments and outcomes. Here, we present a case of 68-year-old female with recalcitrant lymphocytoma cutis resistant to other first-line therapies including tacrolimus ointment and steroids. Read More

Osteoporos Int 2021 Dec 3;32(12):2583-2586. Epub 2021 Jun 3.

Rheumatology department, Ibn Rochd University Hospital, Hassan II University of Medecine and Pharmacy, Casablanca, Morocco.

Zoledronic acid, an amino-bisphosphonate, is an antiresorptive drug given intravenously. It is commonly used for the treatment of severe postmenopausal osteoporosis, and it is also used for other types of osteoporosis, management of bone metastasis, multiple myeloma, hypercalcemia, and Paget's disease. The use varies according to these diseases. Read More

Am J Dermatopathol 2021 Dec;43(12):e280-e284

Department of Dermatology, Changhua Christian Hospital, Changhua, Taiwan.

Abstract: We describe a rare case of cutaneous pseudolymphoma with Langerhans cell hyperplasia. An 84-year-old female patient presented with erythematous and pernicious-looking plaques on her scalp that had been present for months. Histologically, lymphoid follicles consisting of mixed-type lymphocytes and Langerhans cells were aggregated focally. Read More

Dermatol Online J 2021 Apr 15;27(4). Epub 2021 Apr 15.

Section of Dermatology, Department of Internal Medicine, Virginia Tech Carilion School of Medicine and Carilion Clinic, Roanoke, VA.

Palpable migratory arciform erythema (PMAE) is an uncommon T cell pseudolymphoma characterized by erythematous, annular-to-arciform papules and plaques. Although the eruption is self-limited in most cases, recurrences are routine. Diagnosis requires attention to clinical history as well as histopathologic analysis, which allow for differentiation from other T cell pseudolymphomas and gyrate erythemas. Read More

Indian Dermatol Online J 2021 Mar-Apr;12(2):312-315. Epub 2021 Mar 2.

Department of Dermato-Venereo-Leprology, Government Medical College, Nagpur, Maharashtra, India.

Papular lesions over face have a wide range of differential diagnoses. The clinical differentiation among these is difficult and often requires clinicopathological correlation. We hereby report the case of a 28 year old female presenting with numerous skin colored papular lesions over face, pinna and upper limbs. Read More

J Dtsch Dermatol Ges 2021 05 6;19(5):657-669. Epub 2021 May 6.

Department of Dermatology and Allergology, University of Regensburg, Regensburg, Germany.

During tattooing, a high amount of ink is injected into the skin. Tattoo inks contain numerous substances such as the coloring pigments, impurities, solvents, emulsifiers, and preservatives. Black amorphous carbon particles (carbon black), white titanium dioxide, azo or polycyclic pigments create all varieties of color shades in the visible spectrum. Read More

Curr Med Imaging 2022 ;18(3):357-361

Department of Radiology, Necmettin Erbakan University, Meram School of Medicine, Meram, Konya, Turkey.

Background: Pseudolymphoma of the liver (Reactive Lymphoid Hyperplasia) (RLH) is a rare condition. It is usually asymptomatic and detected incidentally on radiological imaging. Imaging features are similar to hepatic adenoma, hepatocellular carcinoma, cholangiocarcinoma, and malignant lymphoma and are not specific for pseudolymphoma of the liver. Read More

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

Division of Population Health, Health Services Research & Primary Care, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK

Pseudolymphomatous folliculitis (PLF) is a rare disease of cutaneous lymphoid hyperplasia, with a low index of clinical suspicion. We present the clinical case of a 19-year-old male patient, with a solitary violet erythematous nodule of 6 months of evolution, located in the right infraorbital region, without presenting another symptomatology. Histopathological examination showed a lymphocytic infiltrate that surrounds the hair follicles, sebaceous and sweat glands that focally destroy their basement membrane. Read More

J Cutan Pathol 2021 Aug 6;48(8):1080-1084. Epub 2021 Jun 6.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA.

Pseudolymphomatous infiltrates associated with angiosarcoma are a rarely reported phenomenon. Recognition of this reactive process is critical to making an accurate diagnosis, both in diagnosing the angiosarcoma and in avoiding an incorrect diagnosis of lymphoma. Here, we present a novel histopathologic pattern, angiosarcoma with a prominently intravascular atypical lymphoid component, mimicking intravascular T-cell lymphoma. Read More

Hautarzt 2022 Feb 21;73(2):152-155. Epub 2021 Apr 21.

Hautklinik, Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland.

The term cutaneous pseudolymphoma (C-PSL) is defined in the literature as a benign, reactive lymphoproliferation that clinically and/or histopathologically imitates cutaneous lymphoma. The exact etiopathogenesis has not been fully elucidated to date. A distinction is made between primary, idiopathic PSL without an identifiable cause and secondary PSL with a known stimulus. Read More