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Indian Dermatol Online J 2021 Mar-Apr;12(2):312-315. Epub 2021 Mar 2.

Department of Dermato-Venereo-Leprology, Government Medical College, Nagpur, Maharashtra, India.

Papular lesions over face have a wide range of differential diagnoses. The clinical differentiation among these is difficult and often requires clinicopathological correlation. We hereby report the case of a 28 year old female presenting with numerous skin colored papular lesions over face, pinna and upper limbs. Read More

J Dtsch Dermatol Ges 2021 May 6;19(5):657-669. Epub 2021 May 6.

Department of Dermatology and Allergology, University of Regensburg, Regensburg, Germany.

During tattooing, a high amount of ink is injected into the skin. Tattoo inks contain numerous substances such as the coloring pigments, impurities, solvents, emulsifiers, and preservatives. Black amorphous carbon particles (carbon black), white titanium dioxide, azo or polycyclic pigments create all varieties of color shades in the visible spectrum. Read More

Curr Med Imaging 2021 May 4. Epub 2021 May 4.

NECMETTİN ERBAKAN ÜNİVERSİTESİ MERAM TIP FAKÜLTESİ, Turkey.

Pseudolymphoma of the liver (reactive lymphoid hyperplasia) (RLH) is a rare condition. It is usually asymptomatic and detected incidentally on radiological imaging. Imaging features are similar to hepatic adenoma, hepatocellular carcinoma, cholangiocarcinoma, and malignant lymphoma and are not specific for pseudolymphoma of the liver. Read More

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

Division of Population Health, Health Services Research & Primary Care, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK

Pseudolymphomatous folliculitis (PLF) is a rare disease of cutaneous lymphoid hyperplasia, with a low index of clinical suspicion. We present the clinical case of a 19-year-old male patient, with a solitary violet erythematous nodule of 6 months of evolution, located in the right infraorbital region, without presenting another symptomatology. Histopathological examination showed a lymphocytic infiltrate that surrounds the hair follicles, sebaceous and sweat glands that focally destroy their basement membrane. Read More

J Cutan Pathol 2021 Mar 1. Epub 2021 Mar 1.

Skin Institute, Department of Dermatology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan.

Eur J Dermatol 2020 Dec;30(6):744-746

Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.

Clin Dermatol 2020 Nov - Dec;38(6):641-647. Epub 2020 Jun 30.

Wake Forest University School of Medicine, Department of Dermatology, Winston-Salem, North Carolina, USA. Electronic address:

Cutaneous manifestations of drug reactions are common yet vary widely in their appearance and degree of internal organ involvement. Serum sickness--like reactions, symmetrical drug-related intertriginous and flexural exanthem, granulomatous drug eruption, pseudolymphoma, and drug-induced lupus are medication-induced conditions with dermatologic presentations. Many of the conditions discussed are relatively rare but nonetheless demand our attention and understanding. Read More

Eur Rev Med Pharmacol Sci 2020 12;24(23):12267-12287

Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy.

Helicobacter pylori is a Gram-negative bacterium identified for the first time about 30 years ago and commonly considered as the main pathogenic factor of gastritis and peptic ulcer. Since then, it was found to be associated with several gastrointestinal and extra-gastrointestinal diseases. Helicobacter pylori is also associated with many skin disorders including, but not limited to, chronic urticaria, rosacea, lichen planus, atopic dermatitis, psoriasis, pemphigus vulgaris, vitiligo, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, primary cutaneous marginal zone B-cell lymphomas and cutaneous T-cell pseudolymphoma. Read More

J Dermatol 2021 Apr 16;48(4):464-469. Epub 2020 Dec 16.

Department of Pathology, International Medical Center, Saitama Medical University, Hidaka, Japan.

Pseudolymphomatous folliculitis (PLF) is a subtype of cutaneous pseudolymphoma that is recognized as an independent disease. PLF is characterized by dermal lymphocytic infiltration surrounding an irregular hyperplastic pilosebaceous unit (i.e. Read More

An Bras Dermatol 2021 Jan-Feb;96(1):68-71. Epub 2020 Nov 16.

Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Rosettes are small white structures visible with polarized light dermoscopy, whose exact morphological correlation is not yet defined. These small shiny structures are found in several conditions such as scarring, dermatofibroma, molluscum contagiosum, squamous cell carcinoma, basal cell carcinoma, melanoma, melanocytic nevus, discoid lupus erythematosus, and papulopustular rosacea. In this novel report, the authors describe the presence of rosettes in a T-cell pseudolymphoma lesion. Read More

Fetal Pediatr Pathol 2020 Nov 5:1-7. Epub 2020 Nov 5.

Pathology & Laboratory Medicine and Pediatrics, Alberta Children's Hospital, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.

Background: Cutaneous pseudolymphoma (CPL) refers to a group of benign, reactive processes that mimic cutaneous lymphoma and are associated with a variety of triggering immune stimuli, including arthropod bites, drugs, and foreign bodies. In children, most cases of CPL are due to a variant of Borreliosis that is specific to Eurasia. Cutaneous pseudolymphoma secondary to ear piercing has only been documented in adults. Read More

Dermatol Ther 2020 11 15;33(6):e14251. Epub 2020 Sep 15.

Department of Pathology, Istanbul Medipol University, Istanbul, Turkey.

J Cutan Pathol 2021 Feb 30;48(2):229-236. Epub 2020 Sep 30.

Department of Pathology, University of Virginia, Charlottesville, Virginia, USA.

In the last 30 years, there has been a strong interest in vascular proliferations. Pyogenic granuloma was not only renamed lobular capillary hemangioma, but also the conceptual interpretation was also changed from an overgrowth of granulation tissue to a genuine hemangioma (or benign vascular neoplasm). We describe 19 cases of patients who presented clinically with a vascular lesion, characteristically a pyogenic granuloma or lobular hemangioma, where the histopathological findings led to the pathologic concern for a lymphoma of the skin. Read More

Sci Rep 2020 07 16;10(1):11834. Epub 2020 Jul 16.

Department of Pathology, Seoul National University Hospital, Seoul, 03080, Republic of Korea.

Aluminium hydroxide is a well-known adjuvant used in vaccines. Although it can enhance an adaptive immune response to a co-administered antigen, it causes adverse effects, including macrophagic myofasciitis (MMF), subcutaneous pseudolymphoma, and drug hypersensitivity. The object of this study is to demonstrate pediatric cases of aluminium hydroxide-induced diseases focusing on its rarity, under-recognition, and distinctive pathology. Read More

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Department of Dermatology, Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria.

Pseudolymphomatous folliculitis is a benign entity that is included within pseudolymphomas. Because of its rapid clinical growth and suspicious histology it has to be differentiated from malignant entities. Given its low frequency, the dermatoscopic characteristics of this entity are not well-characterized and have been described only once previously. Read More

Dermatol Ther 2020 11 5;33(6):e13938. Epub 2020 Aug 5.

Department of Dermatology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.

Pediatr Dermatol 2020 Sep 26;37(5):877-880. Epub 2020 Jun 26.

Department of Medicine, University of Toronto, Toronto, ON, Canada.

Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare, benign disease characterized clinically by multiple, asymptomatic, erythematous papules in the acral regions. We report APACHE in a 12-year-old girl with erythematous-violaceous papules on the lateral dorsum of her foot and toes, and a 3-year-old girl with erythematous papules on the plantar aspect of her foot. Topical rapamycin ointment improved the lesions and both patients tolerated the medication well. Read More

Pathologe 2020 Sep;41(5):515-522

Pathologisches Institut, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland.

The nipple-areola complex is the origin of various morphologically distinct tumors and tumor-like lesions, which can be delineated from the special structures of the nipple, in particular the intramammary ducts, skin-appendages, and the intramammary stroma. Benign tumors are most frequent and this includes epithelial tumors such as mammary adenoma and syringomatous tumor of the nipple. Less commonly observed are benign mesenchymal tumors such as leiomyoma of the nipple, or tumor-like lesions like pseudo-lymphoma. Read More

Dermatol Ther 2020 07 2;33(4):e13637. Epub 2020 Jun 2.

Department of Pathology, Faculty of Medicine, Selcuk University, Konya, Turkey.

J Nippon Med Sch 2020 ;87(2):100-103

Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital.

A 39-year-old Japanese woman presented with a pruritic infiltrated erythematous plaque on the right cheek. Histopathologic analysis of the erythema showed dermal edema, separation of collagen bundles, and nodular perivascular and periadnexal infiltration of lymphocytes in the whole dermis, without epidermal changes. Alcian blue staining intensity was elevated between the collagen bundles, indicating dermal mucinosis. Read More

Cureus 2020 Apr 2;12(4):e7517. Epub 2020 Apr 2.

Pathology, Shiraz University of Medical Sciences, Shiraz, IRN.

Hirudotherapy (leech therapy) is one of the oldest practices in medical history, and nowadays it is used for several purposes in medicine. Salvage of flaps, wound healing, pain management, and treatment of varicose veins are among the common therapeutic applications of leeches. Complications associated with leech therapy include infections, bleeding, anemia, and allergic reaction. Read More

J Med Case Rep 2020 Apr 16;14(1):48. Epub 2020 Apr 16.

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7015, Cincinnati, OH, 45229-3039, USA.

Background: Lyme disease is the most common tick-borne illness in the USA, Canada, and Europe. Clinical manifestations vary greatly, with localized skin findings functioning as early signs of the disease, followed by disseminated disease. The rarest dermatologic presentation of Lyme is a borrelial lymphocytoma, occurring distinctly in Europe and caused typically by Borrelia afzelii. Read More

JAAD Case Rep 2020 Apr 19;6(4):251-253. Epub 2020 Mar 19.

Department of Pathology and Dermatology, MD Anderson of Houston, Houston, Texas.

Australas J Dermatol 2020 Aug 22;61(3):e346-e350. Epub 2020 Jan 22.

National Skin Centre, Singapore, Singapore.

We report an unusual case of drug-associated granulomatous CD30 T-cell pseudolymphoma secondary to amlodipine. A 55-year-old Chinese man presented with a 6-month eruption of disseminated erythematous dermal papulonodules and annular infiltrated plaques over his neck and limbs symmetrically. Histopathology revealed a perivascular and interstitial infiltrate of histiocytes, eosinophils and morphologically normal lymphocytes associated with CD30 expression. Read More

Contact Dermatitis 2020 May 27;82(5):322-324. Epub 2020 Jan 27.

Department of Dermatology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain.

Am J Case Rep 2020 Jan 10;21:e919616. Epub 2020 Jan 10.

Riga Stradins University, Riga, Latvia.

BACKGROUND Pseudolymphoma is a rare disorder that can mimic lymphoma both clinically and histologically. It usually affects middle-aged females. Since pseudolymphoma is a rare disorder not only is diagnosing the condition difficult, but there is also a lack of standardized treatment guidelines. Read More

Dtsch Med Wochenschr 2020 01 8;145(1):19-28. Epub 2020 Jan 8.

Lyme borreliosis is the most common zoonosis in Germany with an incidence of up to 138/100 000. More than 90 % of all cases show dermatological manifestations. Early manifestations are erythema migrans, multiple erythemata migrantia, and (less frequently) borrelial lymphocytoma. Read More

Australas J Dermatol 2020 May 27;61(2):e238-e240. Epub 2019 Dec 27.

Northern Beaches Dermatology, Mona Vale, Australia.

Cutaneous reactions to tattoos are increasing as the prevalence of tattoos increases. Lichenoid reactions often occur in red tattoos and are usually localised to the tattoo. We present a case of recurrent lichenoid reaction occurring in both the black tattooed and adjacent non-tattooed skin. Read More