J Cutan Pathol 2017 Jul 4. Epub 2017 Jul 4.

Dermatology Service, Department of Medicine, New York, NY, USA.

Acral angiokeratoma-like pseudolymphoma is a rare type of pseudolymphoma presenting as dark-red papules on the hand or foot. We describe a 59 year old woman who presented with an unusual unilateral, clustered aggregate of scaly violaceous papules on the toe with an indolent course. Skin biopsy showed a prominent vascular proliferation associated with a dermal infiltrate of monoclonally rearranged T-follicular helper phenotype T-cells, in keeping with CD4+ small/medium T-cell lymphoproliferative disorder (SMPTC-LPD). Read More

Pol J Vet Sci 2017 Mar;20(1):141-147

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Lymphocytic infiltrations located in the extracellular matrix often accompany canine skin cancer. They can be characterised as an inflammatory infiltration and/or a second tumour - lymphoma. The aim of this study was an immunohistochemical analysis of a lymphocytic infiltration which accompanies spontaneous skin cancer. Read More

Curr Probl Dermatol 2017 13;52:42-57. Epub 2017 Mar 13.

The 'Tattoo Clinic', Department of Dermatology, Bispebjerg University Hospital, Copenhagen, Denmark.

Diagnosis of tattoo complications is a multi-facetted field since many clinical entities and disease mechanisms are represented. Infections, allergies, and pigment foreign body reactions with granuloma are the major groups. The clinician needs a structured approach to diagnosis and an armamentarium of standard tests. Read More

J Am Acad Dermatol 2017 Feb;76(2S1):S25-S27

Derma-Aid Centro Dermatógico de Alta Especialidad and Universidad Central del Ecuador, Quito, Ecuador. Electronic address:

J Korean Assoc Oral Maxillofac Surg 2016 Dec 27;42(6):379-382. Epub 2016 Dec 27.

Department of Oral Pathology and Microbiology, KLE Viswanath Katti Institute of Dental Sciences, KLE University, Belagavi, India.

Cutaneous lymphoid hyperplasia (CLH) is a cutaneous pseudolymphoma with a worldwide distribution, equally affecting all races and ethnic groups. Due to its vast array of characteristics, it is most often missed in the differential diagnosis of firm to soft lumps on the head and neck. A systematic approach to the workup and diagnosis along with treatment of such lesions is discussed in this article. Read More

Rev Stomatol Chir Maxillofac Chir Orale 2016 Nov 14;117(5):335-339. Epub 2016 Jul 14.

Aix Marseille université, 13916 Marseille, France; Service de dermatologie, hôpital Nord, AP-HM, 13915 Marseille cedex 20, France.

Introduction: Basal cell carcinoma (BCC) is the most common skin cancer in France. It is commonly diagnosed in front of a papule or nodule of the face. The surgeon should be able to question the diagnosis of BCC when nodular lesions are untypical, keeping in mind that some differential diagnoses require only medical treatment. Read More

J Dermatol 2016 Nov 6;43(11):1367-1368. Epub 2016 Apr 6.

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Clin Exp Dermatol 2016 Dec 20;41(8):906-910. Epub 2016 Oct 20.

Department of Oncology, Hospital Casa de Salud, Valencia, Spain.

Erythema annulare centrifugum (EAC) is a clinical reaction pattern that includes lupus erythematosus, spongiotic dermatitis (particularly pityriasis rosea), pseudolymphoma and cutaneous B-cell lymphoma. However, it can be the result of cutaneous metastasis by an internal carcinoma. We present the case of a 38-year-old woman with bilateral inflammatory breast cancer following multimodal therapy. Read More

Acta Dermatovenerol Croat 2016 Aug;24(3):223-4

Marius Irimie, MD, 40, Zizinului Street, Bl. 31, Sc. C, Ap. 2, 500414, Brasov, Romania;

In the last twenty years, the prevalence of individuals with tattoos in the general population has increased in Europe (1) as well as in Australia (2) and the United States of America (3). A series of complications such as acute inflammatory reactions, allergic contact dermatitis (4,5), photoinduced, lichenoid, and granulomatous reactions (6, 7), pseudolymphoma (8), pseudoepitheliomatous hyperplasia (9), skin infections (6), and skin cancers (10) may occur on tattoos. Infectious complications on tattoos include bacterial infections (pyoderma, leprosy, syphilis, cutaneous tuberculosis, mycobacteriosis) (11-14), viral infections (molluscum contagiosum, warts, herpes simplex, hepatitis B and C) (15-17), and fungal infections (sporotrichosis, dermatophytosis) (18,19). Read More

Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.

School of Medicine.

BackgroundCutaneous reactions to tattoos are most commonly granulomatous or lichenoid.PurposeWe describe a woman who developed a lymphocytic reaction following a cosmetic tattoo procedure with black dye. The reaction occurred not only at the site of the tattoos (eyebrows and eyelash lines), but also in non-tattooed skin (bilateral malar cheeks). Read More

Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.

Singapore General Hospital.

Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare form of cutaneous pseudolymphoma characterized byangiomatous papules with a predilection for the acral regions of children. Classically, a dense dermal lymphocytic infiltrate composed of both T and B cells is seen in histological specimens, together with prominent vessels lined by plump endothelial cells. Increasing evidence suggests that this condition is neither necessarily acral, pseudolymphomatous, nor angiokeratomatous. Read More

J Oral Maxillofac Pathol 2016 May-Aug;20(2):328

Department of Conservative Dentistry and Endodontics, Farooqia Dental College, Mysuru, Karnataka, India.

Small innocuous growths on the face usually do not pose difficulty in diagnosis on histopathology. However, some benign inflammatory lesions might mimic malignancy and hence need further investigations for final diagnosis. The distinction between a benign/inflammatory/malignant lesion needs no emphasis as the treatment plan, prognosis and the patient's well-being depends on it. Read More

Pediatr Dermatol 2016 Nov 30;33(6):e349-e350. Epub 2016 Aug 30.

Department of Dermatology, Henry Ford Health System, Detroit, MI.

Lymphoplasmacytic plaque in children is a rare but increasingly reported clinicopathologic entity characterized by extratruncal erythematous solitary plaques, most often in children and Caucasian girls, that are thought to be a reactive or pseudolymphomatous process. We report a demonstrative case of lymphoplasmacytic plaque in a 3-year-old girl and discuss the clinical and pathologic experience with this entity. Read More

J Am Acad Dermatol 2016 Nov 2;75(5):1000-1006. Epub 2016 Jul 2.

Research Unit of Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria. Electronic address:

Background: Primary cutaneous follicle center lymphoma (pcFCL) usually presents with reddish nodules, plaques, and tumors on the head and neck or the back.

Objective: We sought to describe a peculiar clinical presentation of pcFCL and secondary cutaneous follicle center lymphoma (FCL).

Methods: We report a series of 13 patients (7 male and 6 female; median age 58 years, mean age 58. Read More

Med Monatsschr Pharm 2016 May;39(5):197-204; quiz 205-6

Lyme disease (Lyme borreliosis) is a systemic infectious disease that can present in a variety of clinical manifestations. The disease is caused by a group of spirochaetes--Borrelia burgdorferi sensu lato or Lyme borrelia--that are transmitted to humans by the bite of Ixodes ticks. Lyme disease is the most common arthropode-borne infectious disease in many European countries including Germany. Read More

Clin Infect Dis 2016 Oct 21;63(7):914-21. Epub 2016 Jun 21.

Department of Infectious Diseases, University Medical Center Ljubljana.

Background: Information on the course and outcome of borrelial lymphocytoma (BL) is limited.

Methods: The study comprised 144 adult patients (75 female, 69 male; median age, 49 years) who had BL diagnosed at a single center between 1986 and 2014 and were followed up for 1 year.

Results: BL was located on the breast in 106 patients (73. Read More

Actas Dermosifiliogr 2016 Oct 8;107(8):640-51. Epub 2016 Jun 8.

Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España.

The term cutaneous pseudolymphoma refers to benign reactive lymphoid proliferations in the skin that simulate cutaneous lymphomas. It is a purely descriptive term that encompasses various reactive conditions with a varied etiology, pathogenesis, clinical presentation, histology, and behavior. We present a review of the different types of cutaneous pseudolymphoma. Read More

Am J Dermatopathol 2017 Feb;39(2):89-94

*Regional Medical Laboratories, St. John Medical Center, Tulsa, OK; †Department of Pathology, Weill Cornell Medicine, New York, NY; and ‡Division of Dermatopathology, Department of Pathology, Weill Cornell Medicine, New York, NY.

Background: The cutaneous manifestations of herpes infection are primarily in the context of active infection and of the post-herpetic zosteriform eruption. The former manifests cytopathic alterations diagnostic of herpes. The latter includes lichen planus-like and granuloma annulare-like eruptions and lymphocytoma cutis. Read More

Radiat Oncol J 2016 Mar 30;34(1):76-80. Epub 2016 Mar 30.

Department of Radiation Oncology, Nizam's Institute of Medical Sciences, Hyderabad, India.

Pseudolymphoma is a nonspecific disease characterized by lesions with lymphomatous-appearing but benign accumulation of inflammatory cells. They generally present as small ulcero-nodular lesions confined to skin which often respond to local therapies. We describe an unusual presentation of an extensive and locally aggressive cutaneous pseudolymphoma in a 21-year-old male patient who presented with extensive cutaneous eruptions gradually progressing over 6 years to involve the entire circumference of his left arm. Read More

Am J Dermatopathol 2017 Feb;39(2):95-103

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.

Background: Primary cutaneous CD4 small/medium-sized pleomorphic T-cell lymphoma (PCSTCL) has recently emerged as a distinct clinicopathological entity. Because of a considerable degree of overlap with pseudolymphoma, the diagnosis is often challenging. Preliminary studies suggest that nuclear upregulation of calcineurin/nuclear factor of activated T cells (NFAT) may play a role in lymphomagenesis. Read More

Indian J Dermatol 2016 Mar-Apr;61(2):235

Department of Oncology, Bellevue Medical Center, Beirut, Lebanon.

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) is a severe adverse drug reaction. It can present with clinical, paraclinical, and histological findings mimicking skin and/or systemic lymphomas. We report the first case of a lamotrigine-induced DRESS with histologic features of a cutaneous CD30+ lymphoma. Read More

JAMA Pediatr 2016 Mar;170(3):289-90

Department of Paediatrics, University Hospitals Leuven, Leuven, Belgium2Department of Development and Regeneration, Group of Biomedical Sciences, Katholieke Universiteit Leuven, Belgium.

Acta Derm Venereol 2016 08;96(6):824-5

Department of Dermatology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.

Indian J Dermatol Venereol Leprol 2016 Mar-Apr;82(2):193-5

Department of Dermatology, San Cecilio University Hospital, Granada, Spain.

Intern Med 2015 15;54(24):3201-4. Epub 2015 Dec 15.

Department of Hematology, Kocaeli University Medical Faculty, Turkey.

Anticonvulsant hypersensitivity syndrome is a fatal, idiosyncratic drug reaction that is caused by aromatic antiepileptic drugs. This cutaneous drug reaction is also called pseudolymphoma because of its clinical and histological similarities with malignant lymphoma. The primary clinical findings are fever, skin rashes, enlarged lymph nodes, single or multiple internal organ involvement and hematological abnormalities. Read More

Acta Derm Venereol 2016 May;96(4):570-1

Department of Dermatology, University of Occupational and Environmental Health. 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

Indian J Dermatol 2015 Sep-Oct;60(5):522

Department of Dermatology and Venereology, Govt Medical College, Kozhikode, Kerala, India.

Cutaneous pseudolymphomas are benign lymphoproliferative processes mimicking lymphomas clinically and histologically. One of the precipitating factors for pseudolymphoma is drugs like anticonvulsants, antidepressants and angiotensin-converting enzyme inhibitors. According to existing literature phenytoin-induced cutaneous pseudolymphomas are usually T-cell predominant. Read More

Dermatol Online J 2015 Jul 15;21(7). Epub 2015 Jul 15.

Baylor Scott & White Health, Texas A&M Health Science Center.

Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare entity that typically occurs on the extremities of young females. Although linear arrangement of cutaneous lesions has been rarely reported, accompanying nail dystrophy has not been linked with this condition to our knowledge. We describe a case of linearly-oriented infiltrative papules and nodules on the index finger of a young female with associated onychodystrophy. Read More

An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):77-80

Hospital do Servidor Público Estadual, São Paulo, SP, BR.

Palpable migratory arciform erythema is an entity of unknown etiology, with few published cases in the literature. The clinical and histopathological features of this disease are difficult to be distinguished from those of Jessner's lymphocytic infiltration of the skin, lupus erythematous tumidus and the deep erythema annulare centrifugum. We describe here the first two Brazilian cases of palpable migratory arciform erythema. Read More

Ann Dermatol Venereol 2015 Nov 14;142(11):724-5. Epub 2015 Aug 14.

Département de dermatologie et allergologie, bâtiment des spécialités médicales, 6, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France. Electronic address:

J Cutan Pathol 2015 Sep 26;42(9):600-3. Epub 2015 May 26.

Departments of Dermatology and Pathology, Feinberg Medical School, Northwestern University, Chicago, IL, USA.

Pol Merkur Lekarski 2015 Mar;38(225):166-8

The Department of Pathology, Medical University of Silesia, Katowice, Poland.

The differential diagnosis of pinkish, firm nodules is difficult and has been based mainly on the morphology of vessels in dermoscopy. The aim of the study was to present dermoscopic features of two nodular pilonidal cysts in the diagnostic procedure of pink nodular lesions. The cases presented here belong to a rare variety of nodular pilonidal cysts known as the "motorcyclist's" or " jeep driver's nodule". Read More

Contact Dermatitis 2015 Jun 20;72(6):413-6. Epub 2015 Mar 20.

Department of Dermatology, Faculty of Medicine, University Hospital Complex, 15706, Santiago de Compostela, Spain.

J Am Acad Dermatol 2015 Apr 21;72(4):683-9. Epub 2015 Jan 21.

Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.

Background: With the exception of erythema migrans, Borrelia infection of the skin manifests much more commonly with B cell-rich infiltrates. T cell-rich lesions have rarely been described.

Objective: We report a series of 6 patients with cutaneous borreliosis presenting with T cell-predominant skin infiltrates. Read More

Rom J Morphol Embryol 2014 ;55(4):1527-30

Discipline of Dermatology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Clinic of Dermato-venereology, "St. Spiridon" Emergency Hospital, Iassy, Romania;

Lymphomatoid papulosis, part of the controversial group of cutaneous lymphoproliferative pseudolymphoma disorders, raises important clinical and histopathological problems. It is a chronic, recurrent, clinically characterized by popular necrotic lesions and papulo-pustular nodules, sometimes self-limiting and characterized by histopathological changes suggestive of cutaneous lymphoma (CD30-positive). Since its introduction, in 1968, the term "lymphomatoid papulosis" was subject to dispute in terms of classification in malignancies, premalignant or benign skin disease. Read More

Pathologe 2015 Feb;36(1):62-9

Kempf und Pfaltz, Histologische Diagnostik, Seminarstr. 1, 8042, Zürich, Schweiz,

Primary cutaneous lymphomas are the second most common group of extranodal non-Hodgkin lymphomas. Recently several new variants and entities have been described but have not yet become part of the World Health Organization (WHO) classification. These forms include the granulomatous form of mycosis fungoides, which is associated with a poorer prognosis, as well as indolent CD8+ lymphoproliferations on the head and at acral localizations. Read More

Handchir Mikrochir Plast Chir 2014 Dec 7;46(6):379-82. Epub 2015 Jan 7.

Universitätsklinik für Plastische, Wiederherstellende und Handchirurgie, Zentrum für Schwerbrandverletzte, Paracelsus Medizinische Privatuniversität, Nürnberg.

Allergic reactions occurring after tattooing, especially after the use of red tattoo ink ingredients are relatively rare. We report a painful skin reaction occurring 6 months after the tattoing of the right lower extremity in a 30-year-old female patient. Pathohistological and immunchemical results confirmed a pseudolymphoma. Read More

Indian J Dermatol 2014 Nov;59(6):595-7

Consultant Pathologist, OncQuest Laboratories, 3 Factory Road, New Delhi, India.

Lymphocytoma cutis (LC) is one of the most common types of cutaneous B cell pseudolymphoma. Borrelial LC occurs most commonly in areas endemic for Ixodes ricinus tick in Europe, and it is rare in North America. The disease is rarely seen in India and may cause diagnostic difficulties for dermatologist residing in parts of the world that are not endemic for Lyme disease. Read More

Int J Infect Dis 2015 Jan 13;30:7-9. Epub 2014 Nov 13.

Department of Dermatology, The University of Texas Medical School at Houston and MD Anderson Cancer Center, 1400 Pressler Street Unit 1452, Houston, TX 77030, USA.

We report a case of cutaneous Stenotrophomonas maltophilia infection which presented with clinical and histopathological findings that mimicked a gamma/delta (γδ) T-cell lymphoma. In this case, tissue culture of the biopsy specimen was key to determining the diagnosis and allowing appropriate treatment with oral trimethoprim-sulfamethoxazole and topical silvadene. A prompt complete resolution of lesions was observed following antibiotic treatment, with no recurrence of disease over the last 5 years, supporting an infectious rather than malignant etiology. Read More

An Bras Dermatol 2014 Nov-Dec;89(6):1019-21

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Cutaneous lymphoid hyperplasia (CLH) can be idiopathic or secondary to external stimuli, and is considered rare in tattoos. The infiltrate can be predominantly of B or T-cells, the latter being seldom reported in tattoos. We present a case of a predominantly T CLH, secondary to the black pigment of tattooing in a 35-year-old patient, with a dense infiltrate of small, medium and scarce large T-cells. Read More

J Cutan Pathol 2015 Jan 11;42(1):6-15. Epub 2014 Dec 11.

Dermatopathology Unit, Massachusetts General Hospital, Boston, MA, USA.

Background: Pseudolymphomatous folliculitis is a lymphoid proliferation that clinically and histopathologically mimics primary cutaneous extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In this study, we assessed the diagnostic value of three immunohistochemical markers, programmed death-1 (PD-1), CD1a and S100.

Methods: We evaluated 25 cases of cutaneous lymphoid proliferations with established diagnoses, including 9 patients with pseudolymphomatous folliculitis, 11 with MALT lymphoma, and 5 with cutaneous lymphoid hyperplasia (CLH). Read More

J Cutan Pathol 2015 Jan 9;42(1):50-5. Epub 2014 Dec 9.

Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.

Acral pseudolymphomatous angiokeratoma of children (APACHE) is a disease comprised by a dense dermal infiltrate of B-lymphocytes and T-lymphocytes in which prominent blood vessels with plump endothelium are found. In the past, the lesion was interpreted as a variant of angiokeratoma, a vascular malformation, or a nevus. Currently, most authors consider it to be a type of pseudolymphoma with prominent blood vessels. Read More

Acta Derm Venereol 2015 May;95(5):565-71

Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, A-8036 Graz, Switzerland.

The spectrum of skin manifestations of Lyme borreliosis in children is not well characterized. We conducted a retrospective study to analyze the clinical characteristics, seroreactivity to Borrelia burgdorferi sensu lato, and outcome after treatment in 204 children with skin manifestations of Lyme borreliosis seen in 1996-2011. Solitary erythema migrans was the most common manifestation (44. Read More

Contact Dermatitis 2015 Feb 24;72(2):65-74. Epub 2014 Oct 24.

Section of Dermatology, Department of Surgery, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03766, USA.

Lymphomatoid contact dermatitis is a pseudolymphoma with clinical and histological features of allergic contact dermatitis and cutaneous T cell lymphoma. Incorrect diagnosis may lead to unnecessary testing, unnecessary treatment, or patient harm. The objective of this study is to present a case to demonstrate the diagnostic challenge and overlap between allergic contact dermatitis and cutaneous T cell lymphoma in a patient with lymphomatoid contact dermatitis caused by methylchoroisothiazolinone/methylisothiazolinone and paraben mix, and to review the existing literature in order to summarize the demographics, clinical features, allergens and treatments reported for lymphomatoid contact dermatitis. Read More

Rev Esp Med Nucl Imagen Mol 2015 May-Jun;34(3):162-6. Epub 2014 Oct 8.

Servicio de Medicina Nuclear, Complejo Hospitalario Universitario de Badajoz, Badajoz, España.

Objective: The aim of this study was to evaluate the usefulness of ROLL technique (Radioguided Occult Lesion Localization) as a verification method of suspicious lesions not related to breast disease found in PET-CT studies.

Material And Methods: We retrospectively evaluated 9 patients diagnosed of cancer or with suspected tumor disease who showed hypermetabolic lymph nodes in (18)F-FDG PET-CT. Subjects underwent diagnostic testing for evaluation of treatment response in lymphoma (3), suspected recurrence in other tumors (3) or biopsy guide (3). Read More

Arch Pathol Lab Med 2014 Oct;138(10):1319-27

From the Departments of Pathology (Drs Arps, Chen, Fullen, and Hristov) and Dermatology (Drs Fullen and Hristov), University of Michigan, Ann Arbor.

Mycosis fungoides is the most common primary cutaneous lymphoma; however, it remains a significant diagnostic challenge, in part because of the overlap with several inflammatory dermatoses. Despite advances in immunohistochemistry and molecular diagnostics, false-positive, false-negative, and indeterminate diagnoses are not uncommon. In most cases, the overall balance of morphologic, immunophenotypic, and genetic features must be considered carefully because there are few sensitive and specific clues to the diagnosis. Read More

Arch Pathol Lab Med 2014 Oct;138(10):1307-18

From the Departments of Pathology (Drs Lan, Brown, and Hristov) and Dermatology (Drs Lan and Hristov), University of Michigan Health System, Ann Arbor.

Context: Primary cutaneous CD4⁺ small/medium T-cell lymphoma is a provisional and controversial entity with a broad differential diagnosis. Despite being an uncommon lymphoma, it is a frequent diagnostic consideration in cutaneous biopsies with a dense lymphoid infiltrate because it shows overlapping features with reactive lymphoid hyperplasia (pseudolymphoma) and a variety of other primary cutaneous and systemic lymphomas. However, proper classification of this process is important for determining patient prognosis and treatment options. Read More

J Am Acad Dermatol 2014 Oct;71(4):e149-50

Department of Pathology, Henri Mondor Hospital, Université Paris-Est Créteil, France.

J Dermatol 2014 Sep 25;41(9):856-7. Epub 2014 Aug 25.

Department of Dermatology, Showa University School of Medicine, Tokyo, Japan; Division of Dermatology, Showa University Fujigaoka Hospital, Yokohama, Japan.

J Eur Acad Dermatol Venereol 2015 Jan 14;29(1):7-13. Epub 2014 Aug 14.

Department of Plastic and Reconstructive Surgery, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.

Background: Benign lesions of the breast in total are much more frequent than malignant ones. However, there are no epidemiologic data on the prevalence of benign or malignant tumours of the nipple, and the bibliography on benign nipple tumours in general is limited.

Aims: To present some rare cases of benign nipple tumours and review the literature. Read More