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Pathologe 2020 May 26. Epub 2020 May 26.

Pathologisches Institut, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland.

The nipple-areola complex is the origin of various morphologically distinct tumors and tumor-like lesions, which can be delineated from the special structures of the nipple, in particular the intramammary ducts, skin-appendages, and the intramammary stroma. Benign tumors are most frequent and this includes epithelial tumors such as mammary adenoma and syringomatous tumor of the nipple. Less commonly observed are benign mesenchymal tumors such as leiomyoma of the nipple, or tumor-like lesions like pseudo-lymphoma. Read More

J Nippon Med Sch 2020 ;87(2):100-103

Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital.

A 39-year-old Japanese woman presented with a pruritic infiltrated erythematous plaque on the right cheek. Histopathologic analysis of the erythema showed dermal edema, separation of collagen bundles, and nodular perivascular and periadnexal infiltration of lymphocytes in the whole dermis, without epidermal changes. Alcian blue staining intensity was elevated between the collagen bundles, indicating dermal mucinosis. Read More

Cureus 2020 Apr 2;12(4):e7517. Epub 2020 Apr 2.

Pathology, Shiraz University of Medical Sciences, Shiraz, IRN.

Hirudotherapy (leech therapy) is one of the oldest practices in medical history, and nowadays it is used for several purposes in medicine. Salvage of flaps, wound healing, pain management, and treatment of varicose veins are among the common therapeutic applications of leeches. Complications associated with leech therapy include infections, bleeding, anemia, and allergic reaction. Read More

J Med Case Rep 2020 Apr 16;14(1):48. Epub 2020 Apr 16.

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7015, Cincinnati, OH, 45229-3039, USA.

Background: Lyme disease is the most common tick-borne illness in the USA, Canada, and Europe. Clinical manifestations vary greatly, with localized skin findings functioning as early signs of the disease, followed by disseminated disease. The rarest dermatologic presentation of Lyme is a borrelial lymphocytoma, occurring distinctly in Europe and caused typically by Borrelia afzelii. Read More

JAAD Case Rep 2020 Apr 19;6(4):251-253. Epub 2020 Mar 19.

Department of Pathology and Dermatology, MD Anderson of Houston, Houston, Texas.

Australas J Dermatol 2020 Jan 22. Epub 2020 Jan 22.

National Skin Centre, Singapore, Singapore.

We report an unusual case of drug-associated granulomatous CD30 T-cell pseudolymphoma secondary to amlodipine. A 55-year-old Chinese man presented with a 6-month eruption of disseminated erythematous dermal papulonodules and annular infiltrated plaques over his neck and limbs symmetrically. Histopathology revealed a perivascular and interstitial infiltrate of histiocytes, eosinophils and morphologically normal lymphocytes associated with CD30 expression. Read More

Am J Case Rep 2020 Jan 10;21:e919616. Epub 2020 Jan 10.

Riga Stradins University, Riga, Latvia.

BACKGROUND Pseudolymphoma is a rare disorder that can mimic lymphoma both clinically and histologically. It usually affects middle-aged females. Since pseudolymphoma is a rare disorder not only is diagnosing the condition difficult, but there is also a lack of standardized treatment guidelines. Read More

Dtsch Med Wochenschr 2020 01 8;145(1):19-28. Epub 2020 Jan 8.

Lyme borreliosis is the most common zoonosis in Germany with an incidence of up to 138/100 000. More than 90 % of all cases show dermatological manifestations. Early manifestations are erythema migrans, multiple erythemata migrantia, and (less frequently) borrelial lymphocytoma. Read More

J Complement Integr Med 2019 Dec 4;16(4). Epub 2019 Dec 4.

Radiology Resident, Shiraz University of Medical Sciences, Shiraz, Iran.

For centuries, Hirudo medicinalis (medicinal leech) has been used as a remedy to treat many discomforts, such as muscle and joint pain. Nowadays, using leech in reconstructive surgery, microsurgery, wound and flap healing, venous insufficiency, varicosities and many other disorders has increased. In this study, we report a 45 year old female patient with six pruritic papules on her legs since10 months ago that appeared about 4 weeks after one session of leech application. Read More

Cutis 2019 Aug;104(2):E1-E3

Department of Dermatology, Lehigh Valley Health Network, and Advanced Dermatology Associates, Ltd, Allentown, Pennsylvania, USA.

Acta Dermatovenerol Croat 2019 Jun;27(2):116-120

Professor Liborija Lugović Mihić, MD, PhD, Clinical Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Vinogradska c. 29, 10000 Zagreb, Croatia;

Pseudolymphoma is a benign, reversible, inflammatory, reactive, and polyclonal lymphocyte proliferation, which regresses spontaneously or heals after elimination of the causal factor. A female patient, aged 33, presented with a painful, erythematosus, radiant tumor formation on the skin in the temporal region. The patient had enlarged lymph nodes on the right side of the neck before the appearance of that tumor formation. Read More

Int J Dermatol 2019 Nov 26;58(11):1270-1276. Epub 2019 Jul 26.

Melanoma and Skin Cancer Unit, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Primary cutaneous lymphomas (PCLs) and pseudolymphomas presenting as single pink-red nodules/tumors are highly unspecific and include a wide differential diagnosis.

Objective: To describe the dermoscopic characteristics of PCL/pseudolymphoma.

Methods: In this retrospective, case-control study, we evaluated the dermoscopic features of patients with solitary PCL/pseudolymphoma tumors and compared them to a control group of non-lymphomatous, nonpigmented, solitary tumors (e. Read More

Eur J Microbiol Immunol (Bp) 2019 Jun 11;9(2):46-55. Epub 2019 Apr 11.

Department of Dermatology and Venereology, Medical University Innsbruck, Innsbruck, Austria.

Our research group has recently shown that , the Lyme disease bacterium, is capable of forming biofilms in Borrelia-infected human skin lesions called lymphocytoma (BL). Biofilm structures often contain multiple organisms in a symbiotic relationship, with the goal of providing shelter from environmental stressors such as antimicrobial agents. Because multiple co-infections are common in Lyme disease, the main questions of this study were whether BL tissues contained other pathogenic species and/or whether there is any co-existence with biofilms. Read More

Med Mal Infect 2019 Aug 13;49(5):318-334. Epub 2019 May 13.

Service des maladies infectieuses et réanimation médicale, hôpital Pontchaillou, CHU Pontchaillou, 35033 Rennes cedex, France. Electronic address:

Lyme borreliosis is transmitted en France by the tick Ixodes ricinus, endemic in metropolitan France. In the absence of vaccine licensed for use in humans, primary prevention mostly relies on mechanical protection (clothes covering most parts of the body) that may be completed by chemical protection (repulsives). Secondary prevention relies on early detection of ticks after exposure, and mechanical extraction. Read More

J Cutan Pathol 2019 Oct 11;46(10):717-722. Epub 2019 Jun 11.

Kempf und Pfaltz, Histologische Diagnostik, Zürich, Switzerland, and Department of Dermatology, University Hospital, Zurich, Switzerland.

Background: In cases of herpes virus infection without typical histologic (and clinical) signs it is difficult to achieve the correct diagnosis by histology alone. Some of those cases are prone to be misdiagnosed as cutaneous lymphoma.

Methods: This retrospective study included five patients with herpes simplex virus (HSV)-associated pseudolymphoma. Read More

J Dermatol 2019 09 5;46(9):e335-e337. Epub 2019 Apr 5.

Department of Dermatology, Kido Hospital, Niigata, Japan.

Turkiye Parazitol Derg 2019 Mar;43(1):50-52

Necmettin Erbakan Univercity Meram Faculty of Medicine, Department of Pathology, Konya, Türkiye

Pseudolymphoma, also known as Jessner’s lymphocytic infiltration, is a benign but usually chronic, T-cell infiltrating disease with erythematous papules and plaques usually seen on the skin of the face, neck, and back. The use of leech therapy also known as hirudotherapy has increased in recent years. Here, we report a 52-year-old male patient who had undergone hirudotherapy in his neck and developed infiltrating plaques after four months. Read More

Pediatr Dermatol 2019 May 11;36(3):365-367. Epub 2019 Mar 11.

Department of Dermatology, Grand Hôpital de Charleroi, Charleroi, Belgium.

We report a case of benign lymphoplasmacytic plaque (LPP) in a child. These asymptomatic erythematous papulonodular lesions are an emerging clinicopathological entity. Herein, we describe a previously unreported site for LPP lesions, namely, the volar wrist and the distal ipsilateral palm. Read More

Am J Dermatopathol 2019 Sep;41(9):675-679

Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA.

Immunoglobulin gamma (Ig) type 4-related disease (IgG4-RD) is a chronic immunologic systemic disorder that has gained worldwide recognition in the past decade. This entity can affect almost every organ system, and its characteristic lesions have been found in a variety of organs such as lacrimal and salivary glands, pancreas, liver, bile ducts, lungs, kidneys, retroperitoneum, breast, aorta, thyroid, and prostate. This case reports a very rare case of IgG4-RD presenting with a cutaneous lesion in a young female patient mimicking a lymphoproliferative disorder. Read More

J Dermatolog Treat 2020 Feb 27;31(1):99-102. Epub 2019 Feb 27.

1st Department of Dermatology "Andreas Syggros" Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Although anti-TNFα agents have revolutionized the treatment of many inflammatory diseases, various concerns have been reported regarding the risks of cancer development, as well as acceleration of the progression of subclinical, preexisting malignancies. In this case series, we investigated the provocative effect of anti-TNFα drugs in the development of cutaneous mycosis fungoides (MF)-like lymphoproliferative reactions. We describe five patients aged between 25-63 diagnosed with autoimmune disorders (psoriatic arthritis - one patient, Crohn's disease - one patient and ankylosing spondylitis - three patients) who received anti-TNFα agents before the development of a cutaneous lymphoproliferative reaction. Read More

Dermatol Ther 2019 07 7;32(4):e12807. Epub 2019 Jan 7.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

To explore and compare the clinical presentations and pathologic features of cutaneous pseudolymphomas (CPL) with primary cutaneous lymphomas. Review literature in order to improve the treatment of CPL. Six cases of CPLs were collected. Read More

Eur J Clin Microbiol Infect Dis 2019 Feb 19;38(2):201-208. Epub 2018 Nov 19.

University Hospital "Dr. Jose Eleuterio Gonzalez", Department of Dermatology, Universidad Autonoma de Nuevo Leon, Av. Madero y Gonzalitos s/n, Colonia Mitras Centro, 64460, Monterrey, NL, Mexico.

Lyme disease (borreliosis) is one of the most common vector-borne diseases worldwide. Its incidence and geographic expansion has been steadily increasing in the last decades. Lyme disease is caused by Borrelia burgdorferi sensu lato, a heterogeneous group of which three genospecies have been systematically associated to Lyme disease: B. Read More

J Cutan Pathol 2019 Mar 10;46(3):204-210. Epub 2018 Dec 10.

Department of Dermatology and Allergology, Klinikum Bremen-Mitte, Bremen, Germany.

A 42-year-old Caucasian man suffered from disseminated plaques and ulcerated nodules for 6 weeks. He had weight loss and generalized lymphadenopathy. Underlying diseases were not known up till then. Read More

Cutis 2018 Sep;102(3):E31-E34

Department of Dermatopathology, Western University of Health Sciences, Pomona, California, USA.

Primary cutaneous diffuse large B-cell lymphoma, leg type (DLBCLLT) is a rare, intermediately aggressive form of primary cutaneous B-cell lymphoma (CBCL) that is characterized by the presence of large round cells on histopathology. Clinically, patients present with red-brown nodules on the distal legs. The prognosis is less favorable than other types of CBCLs, with a 5-year survival rate of 50%. Read More

BMJ Case Rep 2018 Oct 21;2018. Epub 2018 Oct 21.

Affiliated Dermatology, Scottsdale, Arizona, USA.

J Cutan Pathol 2019 Feb 14;46(2):134-137. Epub 2018 Nov 14.

University of Washington Division of Dermatology, Seattle, Washington.

We present a case of a widespread fixed drug eruption histologically mimicking CD8 positive cutaneous T-cell lymphoma (CTCL). CTCL has several potential histological and clinical mimics, and accurate diagnosis relies on a combination of clinicopathological correlation and molecular studies. We add generalized fixed drug eruption to the list of possible CTCL mimics. Read More

Pediatr Dermatol 2019 Jan 15;36(1):e1-e5. Epub 2018 Oct 15.

Department of Pathology & Laboratory Medicine, Weill Cornell Medicine, New York, New York.

Acral pseudolymphomatous angiokeratoma of children (APACHE) and unilesional mycosis fungoides (MF) are two rare dermatoses in the pediatric population which may have overlapping clinical and histopathologic features, making differentiation between these two diagnoses difficult. We present two similar cases of a solitary plaque on the thigh of a child, one representing APACHE and the other representing unilesional MF with granulomatous features, and we provide a brief overview of the clinical and histopathologic features of APACHE and unilesional MF. Read More

J Dtsch Dermatol Ges 2018 Oct 1;16(10):1263-1265. Epub 2018 Oct 1.

Department of Specialized, Diagnostic and Experimental Medicine, Hematopathology Unit, Bologna, Italy.

Am J Dermatopathol 2019 Apr;41(4):300-302

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

An 8-year-old girl presented with a persistent 5 × 2-cm violaceous doughy plaque on the left lower leg. Histologic examination revealed hyperkeratosis, variable but mild epidermal hyperplasia, and vacuolar interface changes with melanin pigment incontinence confined to the papillary dermis. A diagnosis of pretibial lymphoplasmacytic plaque in children was made. Read More

Dermatol Clin 2018 Oct 14;36(4):377-388. Epub 2018 Aug 14.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Viale Risorgimento 80, Reggio Emilia 42123, Italy; Dermatology Department, University of Modena and Reggio Emilia, via del Pozzo 71, Modena 41124, Italy.

Primary cutaneous lymphomas are a heterogeneous group that includes 2 main groups of primary T- and B-cell lymphomas, which can involve the skin with distinct variability in clinical presentation, histopathology, immunophenotypes, molecular signature, and prognosis. The authors describe the most frequent clinical forms of cutaneous lymphomas and their dermoscopic features. Even if the diagnosis of these entities is still based on a cellular level and the literature on dermoscopy in cutaneous lymphomas is limited and, for several entities it is based only on single case reports/case series, we think that know how they appear also in dermoscopy can be useful for helping in the clinical diagnosis. Read More

Dermatol Ther 2018 09 7;31(5):e12682. Epub 2018 Sep 7.

Unit of Dermatology and Cosmetology, IRCCS University Vita-Salute San Raffaele, Milan, Italy.

J Dermatol 2019 Feb 26;46(2):e67-e69. Epub 2018 Jul 26.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Appl Immunohistochem Mol Morphol 2018 07;26(6):411-419

Department of Pathology, University of Valencia, Valencia, Spain.

High-endothelial venules are a common feature of 3 types of cutaneous pseudolymphomas: pretibial lymphoplasmacytic plaque (PLP) of children, acral pseudolymphomatous angiokeratoma of children (APACHE), and T-cell rich angiomatoid polypoid pseudolymphoma (TRAPP). In addition, primary cutaneous angioplasmacellular hyperplasia (PCAH) overlaps with these other 3 conditions. We intend to study the expression of peripheral node addressins in PLP, APACHE, TRAPP, and PCAH. Read More

J Investig Allergol Clin Immunol 2018 Jun;28(3):199-201

Allergology Section, Hospital General Universitario de Ciudad Real, Spain.

Semin Cutan Med Surg 2018 Mar;37(1):61-74

Department of Pathology, The American British Cowdray Medical Center, Mexico City, Mexico.

The histopathological diagnosis of dermal-based lymphoid infiltrates and proliferations is often challenging due to the vast list of biologically diverse entities that archetypally or occasionally center in the mid-dermis, especially because significant overlap exists in their clinical, histopathologic, and immunophenotypic features. The differential diagnosis includes reactive infiltrates in common and rare inflammatory dermatoses, benign conditions that may mimic lymphoid neoplasms (pseudolymphomas), and true clonal proliferations arising either primarily in the skin or rarely in extracutaneous tissues with secondary cutaneous dissemination. While numerous histopathological and immunophenotypic features have been reported to support a definitive diagnosis, no single ancillary test is sufficient for their distinction. Read More

JAAD Case Rep 2018 Apr 28;4(3):245-247. Epub 2018 Feb 28.

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

CMAJ 2018 04;190(13):E398

Faculty of Medicine (Zhou), University of Ottawa, Ottawa, Ont.; Division of Dermatology (Mistry), Department of Medicine, University of Toronto, Toronto, Ont.

Dermatitis 2018 May/Jun;29(3):167-168

Dermatology Department, Complejo Asistencial Universitario de León, León, Spain

J Eur Acad Dermatol Venereol 2018 Sep 18;32(9):e358-e360. Epub 2018 May 18.

Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.

J Dtsch Dermatol Ges 2018 Apr 9;16(4):465-467. Epub 2018 Mar 9.

Dermatology Department, Hospital Santo António dos Capuchos, Centro Hospitalar Lisboa Central, Lisbon, Portugal.

J Invest Dermatol 2018 07 23;138(7):1573-1581. Epub 2018 Feb 23.

Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany; Department of Dermatology, Venereology and Allergology and Skin Cancer Center, University Hospital Würzburg, Würzburg, Germany.

Primary cutaneous marginal zone lymphoma (PCMZL) represents an indolent subtype of non-Hodgkin lymphoma that is clinically characterized by slowly growing skin tumors with a very low propensity for systemic dissemination. The underlying genetic basis of PCMZL has not been comprehensively elucidated. To gain deeper insight into the molecular pathogenesis of PCMZL, we performed hybridization-based panel sequencing of 38 patients with well-characterized PCMZL. Read More

Ann Dermatol Venereol 2018 Mar 21;145 Suppl 1:S186-S188. Epub 2018 Feb 21.

J Cutan Pathol 2018 Apr 18;45(4):296-298. Epub 2018 Feb 18.

Associates in Dermatology, MD PL, Fort Myers, Florida.

Cutaneous intravascular CD30+ pseudolymphoma is an uncommon incidental finding that may mimic intravascular or angiotropic lymphoma. We describe a 78-year-old female with a traumatized regressing keratoacanthoma on her left cheek. A shave biopsy revealed intravascular staining of atypical lymphocytes positive for CD45, CD3 and CD30. Read More

Semin Diagn Pathol 2018 Jul 1;35(4):247-259. Epub 2018 Feb 1.

Regional Medical Laboratory, 4142 South Mingo Road, Tulsa, OK 74146-3632, United States.

Atypical lymphocytic infiltrates of the skin comprise a broad spectrum of entities ranging from benign infiltrates to those that are malignant. Many of these infiltrates are in fact reactive lymphomatoid ones related to drug therapy falling under the general category of drug associated pseudolymphoma. Within this nosologic umbrella are nodular and diffuse infiltrates resembling low grade T and B cell lymphoma consistent with lymphocytoma cutis, drug associated reversible T cell dyscrasias which draw a strong morphologic and phenotypic parallel with mycosis fungoides and the various pre-lymphomatous T cell dyscrasias, and angiocentric CD30 positive infiltrates mirroring lymphomatoid papulosis. Read More

J Cutan Pathol 2018 Apr 9;45(4):274-277. Epub 2018 Feb 9.

Departments of Dermatology and Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Lyme disease classically evolves through clinical manifestations according to the stage of illness. Because many of the systemic symptoms are non-specific, and because serology may yield false negative results, cutaneous findings merit even greater importance to diagnosis. The prototypical skin lesion, erythema migrans (EM), occurs early and is the only independent diagnostic clinical feature according to the guidelines of the Infectious Diseases Society of America. Read More

Ann Pathol 2018 Feb 23;38(1):64-67. Epub 2017 Dec 23.

Hospices civils de Lyon, institut de pathologie multisite, centre de biologie sud, centre hospitalier, 165, chemin du Grand-Revoyet, 69310 Pierre-Bénite, France; Université de Lyon 1, 8, avenue Rockefeller, 69003 Lyon, France.

Syphilis is a resurging sexually transmitted infection linked to Treponema Pallidum. Syphilitic lymphadenitis can be present during the 3 stages of the disease. Its histological diagnosis remains challenging for the pathologist given its possible misleading aspect and its ability to mimic as well as reactional as tumoral conditions. Read More

An Bras Dermatol 2017 ;92(5 Suppl 1):98-100

Department of Medicine of the Faculdade Integral Diferencial (Facid-DeVry) - Teresina (PI), Brazil.

Lymphocytoma cutis, or benign reactive lymphoid hyperplasia, is an inflammatory skin lesion that mimics clinically and histologically malignant lymphoma. Most cases are idiopathic, but they may also be triggered by multiple factors, such as insect bites, tattoos, injections and herpes zoster. Clinically, the lesions are erythematous, soft papules, plaques or nodules, usually located on the upper limbs and face. Read More

J Dtsch Dermatol Ges 2018 Jan 20;16(1):96-98. Epub 2017 Dec 20.

Department of Dermatology and Allergology, Technical University of Munich.

Pediatr Dermatol 2018 Jan 4;35(1):e90-e91. Epub 2017 Dec 4.

Division of Dermatology, Department of Pediatrics, School of Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.

Lyme disease is a common tick-borne infection caused by Borrelia burgdorferi in the United States, where infection is most prevalent in the northeastern and mid-Atlantic states. Although classically associated with erythema migrans, Lyme disease caused by Borrelia species found in Europe may also present with other cutaneous findings. Here we report the case of a girl who was clinically diagnosed with Lyme disease based on her history of recent travel and the appearance of an areolar lymphocytoma; this was confirmed by testing. Read More

J Cutan Pathol 2018 Mar 27;45(3):226-228. Epub 2017 Dec 27.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Cutaneous reactions to red tattoo pigment rarely manifest as pseudolymphomatous reactions. We describe an exceedingly rare case of red tattoo-related T-cell predominant pseudolymphoma microscopically mimicking mycosis fungoides. Careful clinicopathological correlation was required to obtain the correct diagnosis and aid in an effective treatment course. Read More