JAAD Case Rep 2018 Apr 28;4(3):245-247. Epub 2018 Feb 28.

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

J Invest Dermatol 2018 Feb 23. Epub 2018 Feb 23.

Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany; Department of Dermatology, Venereology and Allergology and Skin Cancer Center, University Hospital Würzburg, Würzburg, Germany.

Primary cutaneous marginal zone lymphoma (PCMZL) represents an indolent subtype of non-Hodgkin lymphoma that is clinically characterized by slowly growing skin tumors with a very low propensity for systemic dissemination. The underlying genetic basis of PCMZL has not been comprehensively elucidated. To gain deeper insight into the molecular pathogenesis of PCMZL, we performed hybridization-based panel sequencing of 38 patients with well-characterized PCMZL. Read More

Semin Diagn Pathol 2018 Jul 1;35(4):247-259. Epub 2018 Feb 1.

Regional Medical Laboratory, 4142 South Mingo Road, Tulsa, OK 74146-3632, United States.

Atypical lymphocytic infiltrates of the skin comprise a broad spectrum of entities ranging from benign infiltrates to those that are malignant. Many of these infiltrates are in fact reactive lymphomatoid ones related to drug therapy falling under the general category of drug associated pseudolymphoma. Within this nosologic umbrella are nodular and diffuse infiltrates resembling low grade T and B cell lymphoma consistent with lymphocytoma cutis, drug associated reversible T cell dyscrasias which draw a strong morphologic and phenotypic parallel with mycosis fungoides and the various pre-lymphomatous T cell dyscrasias, and angiocentric CD30 positive infiltrates mirroring lymphomatoid papulosis. Read More

J Cutan Pathol 2018 Apr 9;45(4):274-277. Epub 2018 Feb 9.

Departments of Dermatology and Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Lyme disease classically evolves through clinical manifestations according to the stage of illness. Because many of the systemic symptoms are non-specific, and because serology may yield false negative results, cutaneous findings merit even greater importance to diagnosis. The prototypical skin lesion, erythema migrans (EM), occurs early and is the only independent diagnostic clinical feature according to the guidelines of the Infectious Diseases Society of America. Read More

An Bras Dermatol 2017 ;92(5 Suppl 1):98-100

Department of Medicine of the Faculdade Integral Diferencial (Facid-DeVry) - Teresina (PI), Brazil.

Lymphocytoma cutis, or benign reactive lymphoid hyperplasia, is an inflammatory skin lesion that mimics clinically and histologically malignant lymphoma. Most cases are idiopathic, but they may also be triggered by multiple factors, such as insect bites, tattoos, injections and herpes zoster. Clinically, the lesions are erythematous, soft papules, plaques or nodules, usually located on the upper limbs and face. Read More

Pediatr Dermatol 2018 Jan 4;35(1):e90-e91. Epub 2017 Dec 4.

Division of Dermatology, Department of Pediatrics, School of Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.

Lyme disease is a common tick-borne infection caused by Borrelia burgdorferi in the United States, where infection is most prevalent in the northeastern and mid-Atlantic states. Although classically associated with erythema migrans, Lyme disease caused by Borrelia species found in Europe may also present with other cutaneous findings. Here we report the case of a girl who was clinically diagnosed with Lyme disease based on her history of recent travel and the appearance of an areolar lymphocytoma; this was confirmed by testing. Read More

J Cutan Pathol 2018 Mar 27;45(3):226-228. Epub 2017 Dec 27.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Cutaneous reactions to red tattoo pigment rarely manifest as pseudolymphomatous reactions. We describe an exceedingly rare case of red tattoo-related T-cell predominant pseudolymphoma microscopically mimicking mycosis fungoides. Careful clinicopathological correlation was required to obtain the correct diagnosis and aid in an effective treatment course. Read More

Mod Pathol 2018 Mar 17;31(3):378-384. Epub 2017 Nov 17.

Institute for Advanced Biosciences, UGA/Inserm U 1209/CNRS UMR 5309 joint research center, Grenoble, France.

Pathologists typically encounter many disparate exogenous materials in clinical specimens during their routine histopathological examinations, especially within the skin, lymph nodes, and lungs. These foreign substances may be free extracellular deposits or induce several clinical abnormalities or histopathological patterns. However, pathologists almost never investigate or report the chemical nature of exogenous metals in clinical specimens due to a lack of convenient and available technologies. Read More

Acta Derm Venereol 2018 Mar;98(3):310-317

Department of Dermatology, Jena University Hospital Erfurter Straße 35, DE-07743 Jena, Germany.

Cutaneous pseudolymphoma (CPL) is a reactive polyclonal T- or B-cell lymphoproliferative process. CPL may appear as localized or disseminated skin lesions. While most cases of CPL are idiopathic, they may also occur as a response to, for example, contact dermatitis, arthropod reactions, and bacterial infections. Read More

Hum Pathol 2018 Jan 28;71:100-108. Epub 2017 Oct 28.

Department of Pathology and INSERM U955 team 9, AP-HP, Henri-Mondor Hospital, 94220 Créteil, France. Electronic address:

Eruption of lymphocyte recovery (ELR) may occur during bone marrow aplasia after chemotherapies. We reviewed the clinical and pathologic features of 12 patients (male-female ratio, 7:5; median age, 61 years) with an atypical ELR histologically mimicking a primary cutaneous T-cell lymphoma such as Sézary syndrome or CD30+ T-cell lymphoproliferative disorder. All the patients displayed an erythematous maculopapular eruption on the trunk and the limbs associated with fever. Read More

Am J Dermatopathol 2018 Mar;40(3):216-218

Friedrichshafen Dermatopathologie, Friedrichshafen, Germany.

A 5-year-old girl presented with a facial butterfly rash that persisted for 5 months without arthralgia, fever, malaise, photosensitivity, or other symptoms. Lupus erythematosus was clinically suspected. All blood tests were negative or within normal values. Read More

J Cutan Pathol 2017 Oct 24;44(10):878-881. Epub 2017 Jul 24.

Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College, New York, New York.

Acral angiokeratoma-like pseudolymphoma is a rare type of pseudolymphoma presenting as dark-red papules on the hand or foot. We describe a 59-year-old woman who presented with an unusual unilateral, clustered aggregate of scaly violaceous papules on the toe with an indolent course. Skin biopsy showed a prominent vascular proliferation associated with a dermal infiltrate of monoclonally rearranged T-follicular helper phenotype T-cells, in keeping with CD4+ small/medium T-cell lymphoproliferative disorder (SMPTC-LPD). Read More

Acta Trop 2017 Aug 17;172:240-254. Epub 2017 May 17.

Laboratory of Microbiology and Parasitology, Faculty of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil. Electronic address:

Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. Read More

Pol J Vet Sci 2017 Mar;20(1):141-147

.

Lymphocytic infiltrations located in the extracellular matrix often accompany canine skin cancer. They can be characterised as an inflammatory infiltration and/or a second tumour - lymphoma. The aim of this study was an immunohistochemical analysis of a lymphocytic infiltration which accompanies spontaneous skin cancer. Read More

Surg Pathol Clin 2017 Jun 22;10(2):455-476. Epub 2017 Mar 22.

Kempf & Pfaltz, Histologische Diagnostik, Seminarstrasse 1, 8057 Zürich, Zurich, Switzerland; Department of Dermatology, University Hospital Zurich, Gloriastrassse 31, 8091 Zürich, Switzerland.

The term, cutaneous pseudolymphoma (PSL), refers to a group of lymphocyte-rich infiltrates, which either clinically and/or histologically simulate cutaneous lymphomas. Clinicopathologic correlation is essential to achieve the final diagnosis in cutaneous PSL and to differentiate it from cutaneous lymphomas. A wide range of causative agents (eg, Borrelia, injections, tattoo, and arthropod bite) has been described. Read More

Curr Probl Dermatol 2017 13;52:42-57. Epub 2017 Mar 13.

The 'Tattoo Clinic', Department of Dermatology, Bispebjerg University Hospital, Copenhagen, Denmark.

Diagnosis of tattoo complications is a multi-facetted field since many clinical entities and disease mechanisms are represented. Infections, allergies, and pigment foreign body reactions with granuloma are the major groups. The clinician needs a structured approach to diagnosis and an armamentarium of standard tests. Read More

Hautarzt 2017 Apr;68(4):329-339

Abteilung für Dermatologie, Landesklinikum Wiener Neustadt, Wiener Neustadt, Österreich.

Serology, the detection of B. burgdorferi-specific IgM and IgG serum antibodies, is the most common laboratory test to diagnose cutaneous manifestations of Lyme disease. In a two-tiered approach, an ELISA is used as a screening test. Read More

J Am Acad Dermatol 2017 Feb;76(2S1):S25-S27

Derma-Aid Centro Dermatógico de Alta Especialidad and Universidad Central del Ecuador, Quito, Ecuador. Electronic address:

J Korean Assoc Oral Maxillofac Surg 2016 Dec 27;42(6):379-382. Epub 2016 Dec 27.

Department of Oral Pathology and Microbiology, KLE Viswanath Katti Institute of Dental Sciences, KLE University, Belagavi, India.

Cutaneous lymphoid hyperplasia (CLH) is a cutaneous pseudolymphoma with a worldwide distribution, equally affecting all races and ethnic groups. Due to its vast array of characteristics, it is most often missed in the differential diagnosis of firm to soft lumps on the head and neck. A systematic approach to the workup and diagnosis along with treatment of such lesions is discussed in this article. Read More

Rev Stomatol Chir Maxillofac Chir Orale 2016 Nov 14;117(5):335-339. Epub 2016 Jul 14.

Aix Marseille université, 13916 Marseille, France; Service de dermatologie, hôpital Nord, AP-HM, 13915 Marseille cedex 20, France.

Introduction: Basal cell carcinoma (BCC) is the most common skin cancer in France. It is commonly diagnosed in front of a papule or nodule of the face. The surgeon should be able to question the diagnosis of BCC when nodular lesions are untypical, keeping in mind that some differential diagnoses require only medical treatment. Read More

J Dermatol 2016 Nov 6;43(11):1367-1368. Epub 2016 Apr 6.

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Clin Exp Dermatol 2016 Dec 20;41(8):906-910. Epub 2016 Oct 20.

Department of Oncology, Hospital Casa de Salud, Valencia, Spain.

Erythema annulare centrifugum (EAC) is a clinical reaction pattern that includes lupus erythematosus, spongiotic dermatitis (particularly pityriasis rosea), pseudolymphoma and cutaneous B-cell lymphoma. However, it can be the result of cutaneous metastasis by an internal carcinoma. We present the case of a 38-year-old woman with bilateral inflammatory breast cancer following multimodal therapy. Read More

Acta Dermatovenerol Croat 2016 Aug;24(3):223-4

Marius Irimie, MD, 40, Zizinului Street, Bl. 31, Sc. C, Ap. 2, 500414, Brasov, Romania;

In the last twenty years, the prevalence of individuals with tattoos in the general population has increased in Europe (1) as well as in Australia (2) and the United States of America (3). A series of complications such as acute inflammatory reactions, allergic contact dermatitis (4,5), photoinduced, lichenoid, and granulomatous reactions (6, 7), pseudolymphoma (8), pseudoepitheliomatous hyperplasia (9), skin infections (6), and skin cancers (10) may occur on tattoos. Infectious complications on tattoos include bacterial infections (pyoderma, leprosy, syphilis, cutaneous tuberculosis, mycobacteriosis) (11-14), viral infections (molluscum contagiosum, warts, herpes simplex, hepatitis B and C) (15-17), and fungal infections (sporotrichosis, dermatophytosis) (18,19). Read More

Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.

School of Medicine.

BackgroundCutaneous reactions to tattoos are most commonly granulomatous or lichenoid.PurposeWe describe a woman who developed a lymphocytic reaction following a cosmetic tattoo procedure with black dye. The reaction occurred not only at the site of the tattoos (eyebrows and eyelash lines), but also in non-tattooed skin (bilateral malar cheeks). Read More

Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.

Singapore General Hospital.

Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare form of cutaneous pseudolymphoma characterized byangiomatous papules with a predilection for the acral regions of children. Classically, a dense dermal lymphocytic infiltrate composed of both T and B cells is seen in histological specimens, together with prominent vessels lined by plump endothelial cells. Increasing evidence suggests that this condition is neither necessarily acral, pseudolymphomatous, nor angiokeratomatous. Read More

J Oral Maxillofac Pathol 2016 May-Aug;20(2):328

Department of Conservative Dentistry and Endodontics, Farooqia Dental College, Mysuru, Karnataka, India.

Small innocuous growths on the face usually do not pose difficulty in diagnosis on histopathology. However, some benign inflammatory lesions might mimic malignancy and hence need further investigations for final diagnosis. The distinction between a benign/inflammatory/malignant lesion needs no emphasis as the treatment plan, prognosis and the patient's well-being depends on it. Read More

Pediatr Dermatol 2016 Nov 30;33(6):e349-e350. Epub 2016 Aug 30.

Department of Dermatology, Henry Ford Health System, Detroit, MI.

Lymphoplasmacytic plaque in children is a rare but increasingly reported clinicopathologic entity characterized by extratruncal erythematous solitary plaques, most often in children and Caucasian girls, that are thought to be a reactive or pseudolymphomatous process. We report a demonstrative case of lymphoplasmacytic plaque in a 3-year-old girl and discuss the clinical and pathologic experience with this entity. Read More

J Am Acad Dermatol 2016 Nov 2;75(5):1000-1006. Epub 2016 Jul 2.

Research Unit of Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria. Electronic address:

Background: Primary cutaneous follicle center lymphoma (pcFCL) usually presents with reddish nodules, plaques, and tumors on the head and neck or the back.

Objective: We sought to describe a peculiar clinical presentation of pcFCL and secondary cutaneous follicle center lymphoma (FCL).

Methods: We report a series of 13 patients (7 male and 6 female; median age 58 years, mean age 58. Read More

Med Monatsschr Pharm 2016 May;39(5):197-204; quiz 205-6

Lyme disease (Lyme borreliosis) is a systemic infectious disease that can present in a variety of clinical manifestations. The disease is caused by a group of spirochaetes--Borrelia burgdorferi sensu lato or Lyme borrelia--that are transmitted to humans by the bite of Ixodes ticks. Lyme disease is the most common arthropode-borne infectious disease in many European countries including Germany. Read More

Clin Infect Dis 2016 Oct 21;63(7):914-21. Epub 2016 Jun 21.

Department of Infectious Diseases, University Medical Center Ljubljana.

Background: Information on the course and outcome of borrelial lymphocytoma (BL) is limited.

Methods: The study comprised 144 adult patients (75 female, 69 male; median age, 49 years) who had BL diagnosed at a single center between 1986 and 2014 and were followed up for 1 year.

Results: BL was located on the breast in 106 patients (73. Read More

Actas Dermosifiliogr 2016 Oct 8;107(8):640-51. Epub 2016 Jun 8.

Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España.

The term cutaneous pseudolymphoma refers to benign reactive lymphoid proliferations in the skin that simulate cutaneous lymphomas. It is a purely descriptive term that encompasses various reactive conditions with a varied etiology, pathogenesis, clinical presentation, histology, and behavior. We present a review of the different types of cutaneous pseudolymphoma. Read More

Ned Tijdschr Geneeskd 2016 ;160(0):A9808

VU medisch centrum, afd. Dermatologie, Amsterdam.

Introduction: Tattooing involves the introduction of exogenous pigment into the dermis. Worldwide, tattoos are one of the most popular forms of permanent body art. In the Netherlands, 8-10% of the population older than 12 years old has a tattoo. Read More

Am J Dermatopathol 2017 Feb;39(2):89-94

*Regional Medical Laboratories, St. John Medical Center, Tulsa, OK; †Department of Pathology, Weill Cornell Medicine, New York, NY; and ‡Division of Dermatopathology, Department of Pathology, Weill Cornell Medicine, New York, NY.

Background: The cutaneous manifestations of herpes infection are primarily in the context of active infection and of the post-herpetic zosteriform eruption. The former manifests cytopathic alterations diagnostic of herpes. The latter includes lichen planus-like and granuloma annulare-like eruptions and lymphocytoma cutis. Read More

Radiat Oncol J 2016 Mar 30;34(1):76-80. Epub 2016 Mar 30.

Department of Radiation Oncology, Nizam's Institute of Medical Sciences, Hyderabad, India.

Pseudolymphoma is a nonspecific disease characterized by lesions with lymphomatous-appearing but benign accumulation of inflammatory cells. They generally present as small ulcero-nodular lesions confined to skin which often respond to local therapies. We describe an unusual presentation of an extensive and locally aggressive cutaneous pseudolymphoma in a 21-year-old male patient who presented with extensive cutaneous eruptions gradually progressing over 6 years to involve the entire circumference of his left arm. Read More

Am J Dermatopathol 2017 Feb;39(2):95-103

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.

Background: Primary cutaneous CD4 small/medium-sized pleomorphic T-cell lymphoma (PCSTCL) has recently emerged as a distinct clinicopathological entity. Because of a considerable degree of overlap with pseudolymphoma, the diagnosis is often challenging. Preliminary studies suggest that nuclear upregulation of calcineurin/nuclear factor of activated T cells (NFAT) may play a role in lymphomagenesis. Read More

Indian J Dermatol 2016 Mar-Apr;61(2):235

Department of Oncology, Bellevue Medical Center, Beirut, Lebanon.

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) is a severe adverse drug reaction. It can present with clinical, paraclinical, and histological findings mimicking skin and/or systemic lymphomas. We report the first case of a lamotrigine-induced DRESS with histologic features of a cutaneous CD30+ lymphoma. Read More

JAMA Pediatr 2016 Mar;170(3):289-90

Department of Paediatrics, University Hospitals Leuven, Leuven, Belgium2Department of Development and Regeneration, Group of Biomedical Sciences, Katholieke Universiteit Leuven, Belgium.

Acta Derm Venereol 2016 08;96(6):824-5

Department of Dermatology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.

Indian J Dermatol Venereol Leprol 2016 Mar-Apr;82(2):193-5

Department of Dermatology, San Cecilio University Hospital, Granada, Spain.

Intern Med 2015 15;54(24):3201-4. Epub 2015 Dec 15.

Department of Hematology, Kocaeli University Medical Faculty, Turkey.

Anticonvulsant hypersensitivity syndrome is a fatal, idiosyncratic drug reaction that is caused by aromatic antiepileptic drugs. This cutaneous drug reaction is also called pseudolymphoma because of its clinical and histological similarities with malignant lymphoma. The primary clinical findings are fever, skin rashes, enlarged lymph nodes, single or multiple internal organ involvement and hematological abnormalities. Read More

Acta Derm Venereol 2016 May;96(4):570-1

Department of Dermatology, University of Occupational and Environmental Health. 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

Indian J Dermatol 2015 Sep-Oct;60(5):522

Department of Dermatology and Venereology, Govt Medical College, Kozhikode, Kerala, India.

Cutaneous pseudolymphomas are benign lymphoproliferative processes mimicking lymphomas clinically and histologically. One of the precipitating factors for pseudolymphoma is drugs like anticonvulsants, antidepressants and angiotensin-converting enzyme inhibitors. According to existing literature phenytoin-induced cutaneous pseudolymphomas are usually T-cell predominant. Read More

Dermatol Online J 2015 Jul 15;21(7). Epub 2015 Jul 15.

Baylor Scott & White Health, Texas A&M Health Science Center.

Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare entity that typically occurs on the extremities of young females. Although linear arrangement of cutaneous lesions has been rarely reported, accompanying nail dystrophy has not been linked with this condition to our knowledge. We describe a case of linearly-oriented infiltrative papules and nodules on the index finger of a young female with associated onychodystrophy. Read More

An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):77-80

Hospital do Servidor Público Estadual, São Paulo, SP, BR.

Palpable migratory arciform erythema is an entity of unknown etiology, with few published cases in the literature. The clinical and histopathological features of this disease are difficult to be distinguished from those of Jessner's lymphocytic infiltration of the skin, lupus erythematous tumidus and the deep erythema annulare centrifugum. We describe here the first two Brazilian cases of palpable migratory arciform erythema. Read More

Ann Dermatol Venereol 2015 Nov 14;142(11):724-5. Epub 2015 Aug 14.

Département de dermatologie et allergologie, bâtiment des spécialités médicales, 6, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France. Electronic address:

J Cutan Pathol 2015 Sep 26;42(9):600-3. Epub 2015 May 26.

Departments of Dermatology and Pathology, Feinberg Medical School, Northwestern University, Chicago, IL, USA.

Pol Merkur Lekarski 2015 Mar;38(225):166-8

The Department of Pathology, Medical University of Silesia, Katowice, Poland.

The differential diagnosis of pinkish, firm nodules is difficult and has been based mainly on the morphology of vessels in dermoscopy. The aim of the study was to present dermoscopic features of two nodular pilonidal cysts in the diagnostic procedure of pink nodular lesions. The cases presented here belong to a rare variety of nodular pilonidal cysts known as the "motorcyclist's" or " jeep driver's nodule". Read More

Contact Dermatitis 2015 Jun 20;72(6):413-6. Epub 2015 Mar 20.

Department of Dermatology, Faculty of Medicine, University Hospital Complex, 15706, Santiago de Compostela, Spain.

J Am Acad Dermatol 2015 Apr 21;72(4):683-9. Epub 2015 Jan 21.

Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.

Background: With the exception of erythema migrans, Borrelia infection of the skin manifests much more commonly with B cell-rich infiltrates. T cell-rich lesions have rarely been described.

Objective: We report a series of 6 patients with cutaneous borreliosis presenting with T cell-predominant skin infiltrates. Read More

Rom J Morphol Embryol 2014 ;55(4):1527-30

Discipline of Dermatology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Clinic of Dermato-venereology, "St. Spiridon" Emergency Hospital, Iassy, Romania;

Lymphomatoid papulosis, part of the controversial group of cutaneous lymphoproliferative pseudolymphoma disorders, raises important clinical and histopathological problems. It is a chronic, recurrent, clinically characterized by popular necrotic lesions and papulo-pustular nodules, sometimes self-limiting and characterized by histopathological changes suggestive of cutaneous lymphoma (CD30-positive). Since its introduction, in 1968, the term "lymphomatoid papulosis" was subject to dispute in terms of classification in malignancies, premalignant or benign skin disease. Read More