17,486 results match your criteria Lymphedema


Adipose Tissue in Lymphedema: A Central Feature of Pathology and Target for Pharmacologic Therapy.

Lymphat Res Biol 2022 May 20. Epub 2022 May 20.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

Lymphedema is a chronic condition of impaired lymphatic flow that results in limb swelling and debilitation. The pathophysiology of lymphedema is characterized by lymphatic stasis that triggers inflammation, fibrosis, and adipose tissue deposition in the extremities. Most often, this condition occurs in cancer survivors in the years after treatment with combinations of surgery, radiation, or chemotherapy, with the major risk factor being lymph node dissection. Read More

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The frequency and persistence of lymphedema diagnosis and self-reported symptoms over 5 years in patients with endometrial carcinoma.

Gynecol Oncol Rep 2022 Jun 7;41:100996. Epub 2022 May 7.

Division of Gynecologic Oncology, St. Luke's University Health Network, Bethlehem, PA, USA.

A potentially debilitating sequela of diagnosis or treatment for endometrial cancer islower limb lymphedema (LLL), which can have significant impacts on quality of life. Theobjective of this study was to determine the frequency of LLL symptoms in uterinecancer survivors over a 5-year study period. An IRB-approved prospective study of quality of life of endometrial cancer patients whounderwent surgical intervention was undertaken. Read More

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Risk Factors for the Development of Clinical and Subclinical Lymphedema Detected by Bioimpedance Spectroscopy.

Clin Breast Cancer 2022 Apr 22. Epub 2022 Apr 22.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ.

Background: Breast cancer-related lymphedema can significantly compromise quality of life. Bioimpedance spectroscopy (BIS) measures extracellular fluid in lymphedema. The purpose of this study was to determine the incidence of BIS-detected lymphedema using the L-Dex and identify risk factors associated with a positive score. Read More

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Refractory lower limb edema in cancer: subcutaneous drainage.

BMJ Support Palliat Care 2022 May 19. Epub 2022 May 19.

Palliative Care & Rehabilitation Medicine, UT M. D. Anderson Cancer Center, Houston, Texas, USA.

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A meta-analysis of 37 studies on the effectiveness of microsurgical techniques for lymphedema.

Ann Vasc Surg 2022 May 16. Epub 2022 May 16.

Division of Lymphatic Surgery, Department of Vascular Surgery, Engineering Laboratory of Memory and Cognitive Impairment Disease Jilin Province, China‒Japan Union Hospital of Jilin University, Jilin University, Changchun 130031, P. R. China.

Objectives: Microsurgery is a new technique for lymphedema treatment. Its advantages and disadvantages remain controversial. This study sought to collect clinical data from patients who underwent lymphovenous bypass and vascularized lymph node transplantation to explore whether surgical procedures can effectively treat lymphedema. Read More

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[Lymphatic Filariasis Transmission Assessment Survey in Burkina Faso in Connection with 4 Districts].

Med Trop Sante Int 2021 Jun 4;1(2). Epub 2021 Apr 4.

Programme national de lutte contre les maladies tropicales négligées, Ouagadougou, Burkina Faso.

Objective: In this impact survey on the preventive chemotherapy against lymphatic filariasis, the national neglected tropical diseases programme team conducted a Transmission Assessment Survey in the health districts of Leo, Sapouy, Boromo and Dedougou. The purpose of this study was to assess lymphatic filariasis transmission in these four districts (included in two evaluation units (EU): Boucle du Mouhoun 3 and Centre-Ouest 2 after more than ten to thirteen years of mass drug treatment.

Methodology: The study was a cross sectional survey which targeted the school aged children based on the cluster survey method conducted at community level. Read More

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Prolymphangiogenic Effects of 9- Retinoic Acid Are Enhanced at Sites of Lymphatic Injury and Dependent on Treatment Duration in Experimental Postsurgical Lymphedema.

Lymphat Res Biol 2022 May 17. Epub 2022 May 17.

Division of Plastic and Reconstructive Surgery and Keck School of Medicine of USC, Los Angeles, California, USA.

Patients undergoing surgical treatment for solid tumors are at risk for development of secondary lymphedema due to intraoperative lymphatic vessel injury. The damaged lymphatic vessels fail to adequately regenerate and lymphatic obstruction leads to fluid and protein accumulation in the interstitial space and chronic lymphedema develops as a result. There are currently no effective pharmacological agents that reduce the risk of developing lymphedema or treat pre-existing lymphedema, and management is largely palliative. Read More

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Physical and Functional Outcomes of Simultaneous Vascularized Lymph Node Transplant and Lymphovenous Bypass in the Treatment of Lymphedema.

Plast Reconstr Surg 2022 May 19. Epub 2022 May 19.

From the Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medicine & Biological Sciences.

Background: The authors analyze the outcomes of simultaneous vascularized lymph node transplant and lymphovenous bypass for treatment of primary and secondary lymphedema. To the best of their knowledge, this is the largest study to date with long-term outcome data of this novel approach.

Methods: Three hundred twenty-eight patients who underwent physiologic surgical treatment over a 5. Read More

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A novel air microfluidics-enabled soft robotic sleeve: Toward realizing innovative lymphedema treatment.

Biomicrofluidics 2022 May 3;16(3):034101. Epub 2022 May 3.

Department of Mechanical and Mechatronics Engineering, University of Waterloo, 200 University Ave W, Waterloo, Ontario N2L 3G1, Canada.

A proof of concept of a novel air microfluidics-enabled soft robotic sleeve to enable lymphedema treatment is presented. Compression sleeves represent the current, suboptimal standard of care, and stationary pumps assist with lymph drainage; however, effective systems that are truly wearable while performing daily activities are very scarce. This problematic trade-off between performance and wearability requires a new solution, which is addressed by an innovative microfluidic device. Read More

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Technical Tips for Anastomosis of 0.2-mm Diameter Vessels during Lymphatic Venous Anastomosis.

Plast Reconstr Surg Glob Open 2022 May 11;10(5):e4304. Epub 2022 May 11.

International Center for Lymphedema, Hiroshima University Hospital, Hiroshima, Japan.

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Piper retrofractum extract and its component piperine promote lymphangiogenesis via an AKT- and ERK-dependent mechanism.

J Food Biochem 2022 May 13:e14233. Epub 2022 May 13.

Department of Oral and Maxillofacial Prosthodontics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Administration of Piper retrofractum extract (PRE) has been reported to alleviate edema, but the mechanism underlying this effect is unknown. Promotion of lymphangiogenesis is known to improve lymphedema, but the effect of PRE on lymphangiogenesis remains unclear. In the present study, we investigated whether PRE and specifically, piperine, the main component of PRE, can induce lymphangiogenesis. Read More

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Long-Term Survival, Prognostic Factors, and Quality of Life of Patients Undergoing Pelvic Exenteration for Cervical Cancer.

Cancers (Basel) 2022 May 9;14(9). Epub 2022 May 9.

First Obstetrics and Gynecology Clinic, University of Medicine, Pharmacy, Science and Technology "G.E. Palade" of Târgu Mureș, Gheorghe Marinescu Street, Number 38, 540142 Târgu Mureș, Romania.

Background: Considerable efforts have been carried out over the past 30 years to support patients with advanced cervical cancer. Throughout this time, Eastern European countries have been left aside from the decision-making groups on this matter, hence the absence of similar studies in this geographical area. In these countries, the quality of life (QoL) of patients with cervical cancer might be considered a "caprice", and the discomforts they encounter following pelvic exenteration for cervical cancer are often perceived as a "normal phenomenon". Read More

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Induction of Human Dental Pulp Stem Cells to Lymphatic Endothelial Cells.

Cell Reprogram 2022 May 13. Epub 2022 May 13.

State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, National Clinical Research Center for Oral Diseases, Sichuan University, West China Hospital of Stomatology, Chengdu, China.

Lymphedema is a progressive and irreversible disease due to the lymphatic system disorder. Conservative and surgical therapies are either ineffective or impractical. Currently, mesenchymal stem cells (MSCs)-based therapies seem to be the most promising treatment for lymphedema. Read More

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Immediate Lymphatic Reconstruction during Axillary Node Dissection for Breast Cancer: A Systematic Review and Meta-analysis.

Plast Reconstr Surg Glob Open 2022 May 9;10(5):e4291. Epub 2022 May 9.

Section of Plastic Surgery, Department of Surgery, University of Calgary, Calgary, Alberta, Canada.

The objective of this study is to summarize the current body of evidence detailing the impact of immediate lymphatic reconstruction (ILR) on the incidence of breast cancer-related lymphedema (BCRL) following axillary node dissection (ALND).

Methods: Medline and Embase databases were queried for publications, where ILR was performed at the time of ALND for breast cancer. Exclusion criteria included lymphaticovenous anastomosis for established BCRL, animal studies, non-breast cancer patient population studies, and descriptive studies detailing surgical technique. Read More

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Association of lymphatic flow velocity with surgical outcomes in patients undergoing lymphovenous anastomosis for breast cancer-related lymphedema.

Breast Cancer 2022 May 12. Epub 2022 May 12.

Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, South Korea.

Purpose: Lymphovenous anastomosis (LVA) is primarily used for treating early-stage lymphedema. Here, we aimed to investigate the relationship between lymphatic flow velocity and the efficacy of LVA in breast cancer-related lymphedema patients. To this end, we assessed the transit velocity of lymphatic fluid using indocyanine green (ICG) lymphography and radioisotope lymphoscintigraphy. Read More

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A systematic review of axillary nodal irradiation for the management of the axilla in patients with early-stage breast cancer.

Surg Oncol 2022 May 2;42:101754. Epub 2022 May 2.

London Health Sciences Centre, London, Ontario, Canada.

Background: Given numerous publications and clinical trials regarding axillary management in breast cancer, we sought to summarize this complex literature to help clarify this field for clinicians. This systematic review focuses on the role of irradiation of the axillary nodes (locoregional nodal irradiation [LRNI]) in the management of the axilla in patients with early-stage breast cancer in various clinical settings.

Methods: We searched MEDLINE and EMBASE databases, the Cochrane library, the proceedings of the ASCO, the ASTRO, the ESMO, the ESTRO, and the San Antonio Breast Cancer Symposium (2016-2019) meetings. Read More

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Editorial: Modulating Vascular Lymphatic Growth in Disease: Current and Potential Pharmacological Approaches for Prevention and Treatment.

Front Pharmacol 2022 25;13:910142. Epub 2022 Apr 25.

Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Málaga, Andalucía Tech, Málaga, Spain.

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Intra-lesional Corticosteroids and Diathermy Ablation for the Management of Anogenital Granulomatosis: A Retrospective Cohort Study.

Clin Exp Dermatol 2022 May 12. Epub 2022 May 12.

Department of Dermatology, St George's University Hospital, London, UK.

Background: Anogenital Granulomatosis (AGG) is a rare, chronic condition that presents in males and females with progressive inflammation and lymphoedema of the anogenital region. No guidelines exist for its management. Systemic immunosuppressants are the current cornerstone of medical therapy for AGG but results from small-numbered case series have reported variable responses. Read More

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High recurrence of lymphedema and influencing factors in discharged breast cancer patients during the COVID-19 pandemic: A multicenter, cross-sectional survey.

Cancer Med 2022 May 11. Epub 2022 May 11.

Public Health Section, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: There has been a delay in the detection and treatment of lymphedema in breast cancer patients during the lockdown owing to quarantine and limited social activity. Moreover, this scenario has caused psychosocial issues in these patients. Given that there is scarce information on the prevalence and influence of lymphedema during the coronavirus disease (COVID-19) pandemic, we aimed to estimate the prevalence of lymphedema recurrence and its influencing factors among discharged breast cancer patients during the COVID-19 pandemic. Read More

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Radiation-induced angiosarcoma of the vagina and vulva: Case report and review of literature.

Gynecol Oncol Rep 2022 Jun 30;41:100990. Epub 2022 Apr 30.

Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Angiosarcomas are uncommon malignant mesenchymal neoplasms of endothelial origin. They may be primary or secondary to radiation exposure, chronic lymphedema or to other associated risk factors. They can occur anywhere in the body, with the most common location being the skin of the head and neck. Read More

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Liposuction and Controlled Compression Therapy Reduce the Erysipelas Incidence in Primary and Secondary Lymphedema.

Plast Reconstr Surg Glob Open 2022 May 6;10(5):e4314. Epub 2022 May 6.

Department of Clinical Sciences, Malmö, Lund University, Sweden.

Background: Skin infections are a recurring problem for people with lymphedema, and lymphedema has been proven to be the single most important risk factor for developing erysipelas in the leg. This study aimed to determine whether liposuction for late-stage lymphedema reduces the rate of erysipelas in lower extremity lymphedema.

Methods: One-hundred twenty-four patients with a median age of 49 years who had liposuction and controlled compression therapy for lower extremity lymphedema were included. Read More

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Chronic lymphoedema: a nidus for squamous cell carcinoma.

BMJ Case Rep 2022 May 10;15(5). Epub 2022 May 10.

Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Lymphoedema is a chronic debilitating condition characterised by diffuse swelling caused by lymphatic obstruction. The secondary form of lymphoedema is more common than the primary form. Untreated filariasis remains an important cause of lymphoedema in developing countries. Read More

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Progressive resistance exercise training to prevent lower-limb lymphedema after cervical cancer surgery: A feasibility study.

Asia Pac J Oncol Nurs 2022 Jan 25;9(1):32-38. Epub 2021 Dec 25.

Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Objective: Radical hysterectomy with pelvic lymphadenectomy is the standard surgical treatment for early stage cervical cancer. One of the most common complications after this surgery is lower extremity lymphedema (LLL). Program of progressive resistance exercise training (PRET) is a possible way to prevent LLL for cervical cancer patients postoperatively. Read More

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January 2022

[Rehabilitation in lymphedema surgery].

Rehabilitacion (Madr) 2022 May 5. Epub 2022 May 5.

Medicina Física y Rehabilitación, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.

Conservative treatment of lymphedema usually includes complex decongestive therapy in order to reduce the volume of the lymphedema, and compression garments in the maintenance phase. Follow-up is carried out in the Rehabilitation Services. Surgical treatment of lymphedema is a therapeutic option, the interest of which has increased in recent years, although there is no current evidence that it can cure lymphedema and it is always accompanied by conservative treatment. Read More

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Evaluation of Simplified Lymphatic Microsurgical Preventing Healing Approach (SLYMPHA) for the prevention of breast cancer-related lymphedema after axillary lymph node dissection using bioimpedance spectroscopy.

Eur J Surg Oncol 2022 Apr 30. Epub 2022 Apr 30.

University of Miami, Miller School of Medicine, Division of Surgical Oncology, Miami, FL, USA.

Background: Lymphedema is a serious complication of axillary lymph node dissection (ALND) with an incidence rate of 20%. Simplified Lymphatic Microsurgical Preventing Healing Approach (SLYMPHA) is a safe and relatively simple method, which decreases incidence of lymphedema dramatically. Our initial study showed an 88% decrease in clinical lymphedema rate. Read More

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GCIG-Consensus guideline for Long-term survivorship in gynecologic Cancer: A position paper from the gynecologic cancer Intergroup (GCIG) symptom benefit committee.

Cancer Treat Rev 2022 May 2;107:102396. Epub 2022 May 2.

GINECO-Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens, France. Electronic address:

Introduction: Long-term survivors of gynecological cancers may be cured but still have ongoing health concerns and long-term side effects following cancer treatment. The aim of this brainstorming meeting was to develop recommendations for long-term follow-up for survivors from gynecologic cancer.

Methods: International experts, representing each member group within the Gynecologic Cancer InterGroup (GCIG), met to define long-term survival, propose guidelines for long term follow-up and propose ways to implement long term survivorship follow-up in clinical trials involving gynecological cancers. Read More

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Twenty Years Development of Tibial Cortex Transverse Transport Surgery in PR China.

Orthop Surg 2022 May 7. Epub 2022 May 7.

The Second Clinical Medical College of Zhejiang Chinese Medical University, Zhejiang, China.

Tibial cortex transverse transport (TTT) surgery is an extension of the Ilizarov technique. Based on the law of tension-stress, its primary function is to rebuild microcirculation which can relieve ischemic symptoms and promote wound healing. It has received more and more scholars' attention and has experienced a series of changes for 20 years since it entered PR China. Read More

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The Breast Edema Enigma: Features, Diagnosis, Treatment, and Recommendations.

Cureus 2022 Apr 3;14(4):e23797. Epub 2022 Apr 3.

Medical Education, Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Davie, USA.

Breast edema most commonly occurs after breast cancer treatment involving breast-conserving therapy, although it may have a variety of other causes. As compared to research on breast cancer treatment-related lymphedema, breast edema and its objective measurement and diagnosis is far behind. Consequences of this disparity contribute to uncertainty and variability in its diagnosis, its treatment, and even the characterization of its incidence and morbidity. Read More

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Risk Factors Associated With Postmastectomy Breast Cancer Lymphedema: A Multicenter Retrospective Analysis.

Ann Plast Surg 2022 05;88(3 Suppl 3):S239-S245

From the Department of Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY.

Background: Lymphedema is an edematous condition that afflicts the postmastectomy breast cancer population, with diminished quality of life with substantial financial costs. The factors predictive of postmastectomy lymphedema development in breast cancer patients are unknown. The objective was to evaluate the trends over time in lymphedema development and the risk factors predictive of lymphedema-related events within 2 years of mastectomy. Read More

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