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    Lymphedema, musculoskeletal events and arm function in older patients receiving adjuvant chemotherapy for breast cancer (Alliance A171302).
    Breast Cancer Res Treat 2017 Aug 20. Epub 2017 Aug 20.
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Purpose: Musculoskeletal events (MEs) resulting from breast cancer treatment can significantly interfere with the quality of life (QOL) of older adults. We evaluated the incidence of MEs in women 65 years and older who had surgery and adjuvant chemotherapy for breast cancer, and the impact of treatment on MEs and arm function.

    Patients And Methods: Patient-reported data in Alliance/CALGB 49907 were collected using the EORTC QLQ-BR23 and physician-reported adverse events to characterize self-reported MEs and incidence of lymphedema. Read More

    Non-contrast MR lymphography for evaluation of lymph node transfer for secondary upper limb lymphedema.
    Plast Reconstr Surg 2017 Aug 8. Epub 2017 Aug 8.
    1 Department of Radiology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris, 184 Rue du Faubourg Saint-Antoine, 75012 Paris, France / Sorbonne Universités, UPMC 2 Department of Thoracic Surgery, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 20 Rue Leblanc, 75015 Paris.
    Background: Our purpose was to evaluate the results of axillary lymph node transplantation (LNT) with non-contrast magnetic resonance (MR) lymphography in 15 patients with secondary upper limb lymphedema.

    Methods: Fifteen female patients with lymphedema following breast cancer treatment underwent LNT. Non-contrast MR lymphography was obtained with a free-breathing 3D fast spin-echo sequence. Read More

    Vascularized Jejunal Mesenteric Lymph Node Transfer: a Novel Surgical Treatment for Extremity Lymphedema.
    J Am Coll Surg 2017 Aug 14. Epub 2017 Aug 14.
    Department of Plastic Surgery, The Ohio State University, Columbus, OH. Electronic address:
    Background: Vascularized lymph node transfer (VLNT) is a surgical treatment for lymphedema. Multiple donor sites have been described and each has significant disadvantages. We propose the jejunal mesentery as a novel donor site for VLNT. Read More

    The Dutch lymphedema guidelines based on the International Classification of Functioning, Disability, and Health and the chronic care model.
    J Vasc Surg Venous Lymphat Disord 2017 Sep 30;5(5):756-765. Epub 2017 Jun 30.
    Department of Dermatology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands.
    Lymphedema is a chronic and progressive condition due to an imbalance between lymphatic filtration and transport capacity. A relative overload of fluid is caused by lymphatic impairment (afterload impairment); an absolute overload is caused by increased filtration (preload raised). Lymphedema can result in considerable disability and loss of quality of life. Read More

    Impact of an educational program on the quality of life of patients with lymphedema: A preliminary evaluation.
    J Vasc Surg Venous Lymphat Disord 2017 Sep;5(5):715-722.e1
    Department of Vascular Medicine, Pôle Pluridisciplinaire de Médecine et de Gérontologie Clinique, Grenoble Alpes University Hospital, Grenoble, France; GRANTED Network, Saint Martin d'Hères, France.
    Objective: We report on the preliminary evaluation of a well-designed program, Living with Lymphedema. This longitudinal cohort study assessed patients' quality of life using questionnaires. Our main objective was to evaluate the satisfaction of the patients and their adherence to the program. Read More

    Preventable and mitigable adverse events in cancer care: Measuring risk and harm across the continuum.
    Cancer 2017 Aug 17. Epub 2017 Aug 17.
    Tufts Medical Center, Boston, Massachusetts.
    Background: Patient safety is a critical concern in clinical oncology, but the ability to measure adverse events (AEs) across cancer care is limited by a narrow focus on treatment-related toxicities. The objective of this study was to assess the nature and extent of AEs among cancer patients across inpatient and outpatient settings.

    Methods: This was a retrospective cohort study of 400 adult patients selected by stratified random sampling who had breast (n = 128), colorectal (n = 136), or lung cancer (n = 136) treated at a comprehensive cancer center in 2012. Read More

    Long-Term Survival After Hematopoietic Stem Cell Transplantation for Complete STAT1 Deficiency.
    J Clin Immunol 2017 Aug 16. Epub 2017 Aug 16.
    U.O. Oncoematologia pediatrica e Trapianto di Midollo osseo, Asst Spedali Civili, Brescia, Italy.
    Purpose: Complete signal transducer and activator of transcription 1 (STAT1) deficiency is a rare autosomal recessive condition characterized by impairment of intracellular signaling from both type I and type II interferons (IFN). Affected patients are prone to early severe mycobacterial and viral infections, which usually result in death before 18 months of age. We previously reported a patient affected by complete STAT1 deficiency who underwent hematopoietic stem cell transplantation (HSCT). Read More

    VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations.
    JCI Insight 2017 Aug 17;2(16). Epub 2017 Aug 17.
    Mammalian Cell Signaling Laboratory, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
    Background: Lack of investigatory and diagnostic tools has been a major contributing factor to the failure to mechanistically understand lymphedema and other lymphatic disorders in order to develop effective drug and surgical therapies. One difficulty has been understanding the true changes in lymph vessel pathology from standard 2D tissue sections.

    Methods: VIPAR (volume information-based histopathological analysis by 3D reconstruction and data extraction), a light-sheet microscopy-based approach for the analysis of tissue biopsies, is based on digital reconstruction and visualization of microscopic image stacks. Read More

    Current and future perspectives on the evaluation, prevention and conservative management of breast cancer related lymphoedema: A best practice guideline.
    Eur J Obstet Gynecol Reprod Biol 2017 Aug 4. Epub 2017 Aug 4.
    Multidisciplinary Oedema Clinic, University of Antwerp and Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium; University of Antwerp, Faculty of Medicine and Health Sciences, Department of Medicine, Universiteitsplein 1, 2610 Wilrijk, Belgium; Antwerp University Hospital, Multidisciplinary Breast Clinic, Wilrijkstraat 10, 2650 Edegem, Belgium. Electronic address:

    Painless swollen calf muscles of a 75-year-old patient caused by bilateral venous malformations.
    World J Orthop 2017 Jul 18;8(7):602-605. Epub 2017 Jul 18.
    Roderick S M Piekaar, Eline W Zwitser, Joris A Jansen, Department of orthopaedic surgery, Alrijne Hospital, 2353 GA Leiderdorp, The Netherlands.
    A 75-year-old man presented with knee pain due to medial osteoarthritis of the knee in the orthopedic outpatient clinic. Conservative treatment was started with steroid infiltration. Besides his knee complaint reported a bilateral painless swollen calf muscle without traumatic cause, and also without any pain at night, fever or medical illness. Read More

    Lymphangiectatic Variant of Eccrine Spiradenoma - A Diagnostic Challenge.
    S D Med 2016 Aug;69(8):359-361
    Sanford Pathology Clinic, Sioux Falls, South Dakota.
    Conventional eccrine spiradenoma is a benign, slow growing and painful tumor of the skin. While the tumor does not usually present a diagnostic dilemma, a rare variant with marked stromal lymphedema can be a challenge to interpret. We present a case of lymphangiectatic variant of eccrine spiradenoma in an 82-year-old white male who presented with a persistent left flank lesion for several months. Read More

    [Plastic surgery reconstruction of the adult buried penis : Option or obligation?]
    Urologe A 2017 Aug 11. Epub 2017 Aug 11.
    Klinik für Plastische und Ästhetische Chirurgie - Handchirurgie - Wiederherstellungschirurgie, St. Antonius-Hospital Eschweiler, Aachen, Deutschland.
    The adult buried penis afflicts the patient with shame and is also potentially associated with considerable urogenital complications. Due to obesity, chronic urogenital lymphedema or subsequent inflammatory urogenital conditions, such as a lichen sclerosus et atrophicus, the clinical appearance of the adult buried penis is extremely variable. Epidemiological data are non-existent. Read More

    Risk factors of pain in breast cancer survivors: a systematic review and meta-analysis.
    Support Care Cancer 2017 Aug 10. Epub 2017 Aug 10.
    Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Building F-Kine, Laarbeeklaan 103, BE-1090, Brussels, Belgium.
    Background: Breast cancer remains the number 1 lethal malignancy in women. With rising incidence and decreased mortality, the number of breast cancer survivors has increased. Consequently, sequelae, such as pain, are becoming more important. Read More

    Preventing early postoperative arm swelling and lymphedema manifestation by compression sleeves after axillary lymph node interventions in breast cancer patients: A randomized controlled trial.
    J Pain Symptom Manage 2017 Aug 7. Epub 2017 Aug 7.
    Medical University of Vienna, Baumeistergasse 85, A 1160 Vienna, Austria.
    Context: Breast cancer related lymphedema (BCRL) remains one of the major long-term complications after surgery. Many reports showed the effectiveness of compression in BCRL treatment but randomized controlled trials evaluating compression garments for postoperative prevention are lacking.

    Objectives: The aim of the study was to evaluate the potential role of light arm compression sleeves for reducing the incidence of early postoperative swelling and of breast cancer related arm lymphedema. Read More

    Role of handedness on forearm skin tissue dielectric constant (TDC) in relation to detection of early-stage breast cancer-related lymphedema.
    Clin Physiol Funct Imaging 2017 Aug 10. Epub 2017 Aug 10.
    College of Medical Sciences, Nova Southeastern University, Ft. Lauderdale, FL, USA.
    skin tissue dielectric constant (TDC) measurements help assess local skin water to detect incipient early-stage lymphedema subsequent to breast cancer treatment-related lymphedema. However, presurgery measurements are not always obtained and assessments for evolving lymphedema are only made after surgery. Thus, subsequent TDC assessments may be biased in an unknown way dependent on a patient's handedness in relation to the at-risk arm. Read More

    Capacity of gold nanoparticles in cancer radiotherapy.
    Jpn J Radiol 2017 Aug 9. Epub 2017 Aug 9.
    Department of Biochemistry and Molecular Biology, College of Applied Science, University of Bahri, Bahri El-Ingaz Street, West Railway, P.O Box 1660, 11111, Khartoum, Sudan.
    Radiotherapy is the ionizing radiation used for treatment of cancer and other diseases. Although radiotherapy is the major treatment for cancer, a lot of patients do not undergo radiation due to associated risks such as radiation pneumonitis, cardiovascular complications, development of secondary tumor, and lymphedema. However, the advantages of nanotechnology provide a unique potential to enhance radiotherapeutic performance, in particular by utilizing gold nanoparticles (Au NPs). Read More

    Clinical applications of chemical exchange saturation transfer (CEST) MRI.
    J Magn Reson Imaging 2017 Aug 9. Epub 2017 Aug 9.
    Department of Biomedical Engineering, University of Arizona, Tucson, Arizona, USA.
    Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has been developed and employed in multiple clinical imaging research centers worldwide. Selective radiofrequency (RF) saturation pulses with standard 2D and 3D MRI acquisition schemes are now routinely performed, and CEST MRI can produce semiquantitative results using magnetization transfer ratio asymmetry (MTRasym ) analysis while accounting for B0 inhomogeneity. Faster clinical CEST MRI acquisition methods and more quantitative acquisition and analysis routines are under development. Read More

    Otophyma, Rhinophyma and Telangiectatic Rosacea - A Rare Combination in a Female Patient.
    Open Access Maced J Med Sci 2017 Jul 19;5(4):531-532. Epub 2017 Jul 19.
    Polyclinic for Dermatology and Venerology, University Hospital Lozenetz, Academic Educational Hospital of the Saint Kliment Ohridski University, Medical Faculty, Koziak Street 1, Dermatology, Venereology and Dermatologic Surgery; Onkoderma, Private Clinic for Dermatologic Surgery, Dermatology and Surgery, Sofia 1407, Bulgaria.
    Background: Rosacea is an inflammatory facial dermatosis seen more frequently in adults in their second half of life. The phymas are a particular subtype with sebaceous gland hyperplasia and progressive fibrosis.

    Case Report: We report on the rare simultaneous occurrence of telangiectatic rosacea, otophyma and rhinophyma in a 50-year-old female with psoriatic arthritis, chronic lymphedema of the legs, and metabolic syndrome. Read More

    Hereditary Lymphedema of the Leg - A Case Report.
    Open Access Maced J Med Sci 2017 Jul 19;5(4):451-453. Epub 2017 Jul 19.
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
    Primary of hereditary lymphedema is a rare but progressive disease. It is yet not curable. We present a 48-year-old male patient with hereditary lymphedema of his left leg, that was realised by minor trauma (able twist) when he was seven years old. Read More

    The surgical anatomy of the vascularized lateral thoracic artery lymph node flap-A cadaver study.
    J Surg Oncol 2017 Aug 7. Epub 2017 Aug 7.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
    Background: One promising surgical treatment of lymphedema is the VLNT. Lymph nodes can be harvested from different locations; inguinal, axillary, and supraclavicular ones are used most often. The aim of our study was to assess the surgical anatomy of the lateral thoracic artery lymph node flap. Read More

    High-resolution MR lymphangiography for planning lymphaticovenous anastomosis treatment: a single-centre experience.
    Radiol Med 2017 Aug 2. Epub 2017 Aug 2.
    Department of Medical, Surgical and Neuro Sciences, Unit of Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy.
    Purpose: This article illustrates the feasibility of MR lymphangiography (MRL) for imaging lymphatic vessels in patients with lymphedema, its accuracy in distinguishing lymphatic vessels from veins, and its utility for planning Lymphaticovenous anastomosis (LVA) treatment.

    Materials And Methods: We prospectively enrolled 30 patients (24 women, range 18-70, 17 cases of lower limb lymphedema, 6 cases of primary lymphedema). All the patients underwent MRL, using a 1. Read More

    Breast Cancer-Related Lymphedema Risk is Related to Multidisciplinary Treatment and Not Surgery Alone: Results from a Large Cohort Study.
    Ann Surg Oncol 2017 Aug 1. Epub 2017 Aug 1.
    Department of Surgery, Mayo Clinic, Rochester, MN, USA.
    Background: Breast cancer-related lymphedema (BCRL) is a significant complication for women undergoing treatment. We assessed BCRL incidence and risk factors in a large population-based cohort.

    Methods: We utilized the Olmsted County Rochester Epidemiology Project Breast Cancer Cohort from 1990-2010 and ascertained BCRL and risk factors. Read More

    Considerations for Clinicians in the Diagnosis, Prevention, and Treatment of Breast Cancer-Related Lymphedema, Recommendations from an Expert Panel: Part 2: Preventive and Therapeutic Options.
    Ann Surg Oncol 2017 Aug 1. Epub 2017 Aug 1.
    Division of Breast Surgery and Breast Surgical Oncology, Montefiore Medical Center, The University Hospital for the Albert Einstein College of Medicine, Montefiore Einstein Center for Cancer Care, 1521 Jarrett Place, New York, NY, 10461, USA.

    Perceived barriers and preferred components for physical activity interventions in African-American survivors of breast or endometrial cancer with type 2 diabetes: the S.U.C.C.E.S.S. framework.
    Support Care Cancer 2017 Aug 1. Epub 2017 Aug 1.
    Department of Obstetrics and Gynecology Center for Women's Health Research, University of North Carolina at Chapel Hill, 3027 Old Clinic Building, Campus Box #7570, Chapel Hill, NC, 28599, USA.
    Purpose: African-American (AA) female cancer survivors share a disproportionate burden of diabetes compared to their white counterparts. Our objectives were to explore the perspectives of AA survivors with type 2 diabetes on perceived barriers to physical activity (PA) and preferences for a PA intervention and develop a framework for a PA program after cancer treatment.

    Methods: Trained interviewers conducted semi-structured interviews with AA survivors of breast or endometrial cancer with diabetes (total n = 20; 16 breast, 4 endometrial). Read More

    Sentinel Lymph Node Biopsy in the Management of Vulvar Carcinoma: An Evidence-Based Insight.
    Int J Gynecol Cancer 2017 Aug 1. Epub 2017 Aug 1.
    Mater Dei Hospital, Msida, Malta.
    Objective: Lymph node metastasis has been shown to represent the most significant prognostic factor in vulvar carcinoma. Because only 25% to 35% of patients with early stage disease have lymph node metastases, a significant 65% to 75% possibly do not benefit from elective inguinofemoral lymphadenectomy considering the related morbidities of wound infection, breakdown, and lower limb lymphedema. This review article aims to present and summarize the evidence available with regard to sentinel lymph node (SLN)-guided management of vulvar carcinoma. Read More

    Guidelines for teaching yoga to women with breast cancer-related lymphoedema: an evidence-based approach.
    Int J Yoga Therap 2017 Aug 1. Epub 2017 Aug 1.
    4. Department of Surgery, Flinders University, Adelaide, Australia.
    Breast cancer-related lymphoedema (BCRL) is a chronic condition that requires lifelong management to prevent the condition worsening and to reduce the threat of infection. Women are affected in all domains of their life. As a holistic practice, yoga may be of benefit by reducing both the physical and psychosocial effects of lymphoedema. Read More

    Reliability and Diagnostic Thresholds for Ultrasound Measurements of Dermal Thickness in Breast Lymphedema.
    Lymphat Res Biol 2017 Jul 31. Epub 2017 Jul 31.
    1 Discipline of Physiotherapy, Faculty of Health Sciences, University of Sydney , Lidcombe, Australia .
    Background: Lymphedema of the breast, secondary to treatment for breast cancer, is difficult to assess due to the shape of the breast and the nature of the tissue. Ultrasound measurement of dermal thickness has been previously used to assess breast swelling; however, the reliability of the measurements, or what should be considered an abnormal thickness, is currently known.

    Methods And Results: Thirty-eight women with breast edema were recruited and underwent assessment using ultrasound. Read More

    An Experimental Lymphedema Animal Model for Assessing the Results of Lymphovenous Anastomosis.
    Lymphat Res Biol 2017 Jul 31. Epub 2017 Jul 31.
    1 Department of Plastic Surgery, Hospital Santa Creu i Sant Pau, Universitat Autònoma de Barcelona , Barcelona, Spain .
    Background: The lymphatic system is the least studied of the body's systems, and as a result its contribution to human health and diseases is not well known. The failure of the lymphatic system to drain extravasated fluid efficiently leads to accumulation of lymph in the interstitial tissue, thus causing lymphedema. Despite developments in microsurgery procedures, the results of lymphedema treatment remain disappointing. Read More

    Tonometry of Deep Tissues for Setting Effective Compression Pressures in Lymphedema of Limbs.
    Lymphat Res Biol 2017 Jul 31. Epub 2017 Jul 31.
    5 Lehigh University , Bethlehem, Pennsylvania.
    Background: The therapeutic intermittent pneumatic compression (IPC) pressures are usually set arbitrarily at levels between 40 and 60 mmHg. However, it is not known how much force has been transferred to edema fluid. There is a need to know how high edema fluid pressures should be generated to evacuate the stagnant fluid. Read More

    Evaluation of Stiffness in Postmastectomy Lymphedema Using Acoustic Radiation Force Impulse Imaging: A Prospective Randomized Controlled Study for Identifying the Optimal Pneumatic Compression Pressure to Reduce Stiffness.
    Lymphat Res Biol 2017 Jul 31. Epub 2017 Jul 31.
    Department of Rehabilitation Medicine, Chungnam National University Hospital, Daejeon, South Korea .
    Purpose: We aimed to assess the improvement in stiffness in patients with postmastectomy lymphedema (PMLE) after intermittent pneumatic compression (IPC) using acoustic radiation force impulse (ARFI) imaging and evaluate the effects of different IPC pressures.

    Methods: We randomly assigned 45 patients with PMLE (stage II) to three groups based on the IPC pressure: 25, 35, and 45 mmHg. Patients received a single session of IPC for 30 minutes. Read More

    Complications following completion lymphadenectomy versus therapeutic lymphadenectomy for melanoma - A systematic review of the literature.
    Eur J Surg Oncol 2017 Jul 21. Epub 2017 Jul 21.
    Warwick Medical School, The University of Warwick, Coventry, CV4 7AL, United Kingdom; Department of Plastic Surgery, University Hospitals of Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry, CV2 2DX, United Kingdom. Electronic address:
    Purpose: Completion lymph node dissection (CLND) following a positive sentinel lymph node biopsy (SLNB) has been reported to be less morbid than lymphadenectomy for palpable disease (therapeutic lymph node dissection; TLND). The reporting of morbidity data can be heterogeneous, and hence no 'average' surgical complication rates of these procedures has been reported. This review aims to determine complications rates to inform patients undergoing surgery for metastatic melanoma. Read More

    "Adipose-Derived Stem Cells and Vascularized Lymph Node Transfers Successfully Treat Mouse Hindlimb Secondary Lymphedema by Early Reconnection of the Lymphatic System and Lymphangiogenesis."
    Plast Reconstr Surg 2017 Jul 15. Epub 2017 Jul 15.
    1. Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College; Beijing China.

    Adipose-Derived Stem Cells and Vascularized Lymph Node Transfers Successfully Treat Mouse Hindlimb Secondary Lymphedema by Early Reconnection of the Lymphatic System and Lymphangiogenesis.
    Plast Reconstr Surg 2017 Jul 15. Epub 2017 Jul 15.
    Professor-in-Chief, Department of Plastic Surgery, Wound Repair and Regeneration, Fukuoka University, School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 8140180, Japan. Tel: +81 92 866 8250 (direct), Tel: +81 92 801 1011 (ext. 2396), Fax: +81 92 866 8251.

    Upper limb lymphedema in breast cancer patients in the era of Z0011, sentinel lymph node biopsy and breast conservation.
    Ir J Med Sci 2017 Jul 27. Epub 2017 Jul 27.
    Department of Breast Surgery, University Hospital Limerick, Limerick, Ireland.
    Introduction: Surgical techniques in breast cancer (BCa) have seen a dramatic change recently with breast-conserving surgery (BCS) and sentinel lymph node biopsy (SLNB). The ACOSOG-Z0011 trial reported equivalence in outcomes for certain patients with SLN metastases treated with axillary lymph node dissection (ALND) or SLNB alone. Our aim was to investigate changes in lymphedema referral patterns in BCa patients over the last 3 years in a specialist unit and to elucidate effects of SLNB, BCS, and Z0011 trial publication on such patterns. Read More

    Investigating the Short-Term Effects of Manual Lymphatic Drainage and Compression Garment Therapies on Lymphatic Function Using Near-Infrared Imaging.
    Lymphat Res Biol 2017 Jul 27. Epub 2017 Jul 27.
    Clinical Academic Facility, Faculty of Health Sciences, University of Southampton , Southampton, United Kingdom .
    Background: Lymphedema is a chronic peripheral swelling caused by a dysfunction of the lymphatic system, leading to discomfort and loss of upper limb movement. Therapies to treat or manage this swelling have limited evidence, partly because of a paucity in objective lymphatic measures. This study explored the role of near-infrared (NIR) imaging in evaluating interventions. Read More

    Computed Tomographic Evaluation of Posttreatment Soft-Tissue Changes by Using a Lymphedema Scoring System in Patients with Oral Cancer.
    Lymphat Res Biol 2017 Jul 27. Epub 2017 Jul 27.
    1 Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine , Chuo-ku, Kobe, Japan .
    Background: This study aimed to evaluate posttreatment soft-tissue changes in patients with oral cancer with computed tomography (CT). To accomplish that purpose, a scoring system was established, referring to the criteria of lower leg lymphedema (LE).

    Methods And Results: One hundred and six necks in 95 patients who underwent oral oncologic surgery with neck dissection (ND) were analyzed retrospectively using routine follow-up CT images. Read More

    Measurement of Local Tissue Water in Patients with Breast Cancer-Related Lymphedema.
    Lymphat Res Biol 2017 Jul 27. Epub 2017 Jul 27.
    2 Abant Izzet Baysal University , Faculty of Medicine, Department of Medical Oncology, Bolu, Turkey .
    Background: Studies revealed that having "1.20" or upper interarm local tissue water (LTW) ratio which can be calculated through tissue dielectric constant (TDC) method might be the determinant of clinical lymphedema after breast cancer surgery. The purpose of this study was to confirm these findings and determine the sensitivity and specificity of LTW (%) measurement method in patients with breast cancer related lymphedema (BCRL). Read More

    Circumference-Based Criteria for Detection of Secondary Arm Lymphedema for Chinese Women.
    Lymphat Res Biol 2017 Jul 27. Epub 2017 Jul 27.
    3 Faculty of Health Sciences, University of Sydney , Sydney, Australia .
    Background: Detection of upper limb lymphedema following treatment for breast cancer typically relies on interlimb circumference-based differences. Normative-determined criteria from an Australian population have high sensitivity and specificity for detection of mild lymphedema in Australian women. It is unknown whether these criteria are applicable to Chinese women whose body habitus is different from Australian women. Read More

    Predilection to Dermato-Lymphangio-Adenitis in Obstructive Lymphedema of Lower Limbs Depending on Genetic Polymorphisms at TNFα-308G>A, CCR2-190G>A, CD14-159C>T, TLR2 2029C>T, TLR4 1063A>G, TLR4 1363C>T, TGFβ 74G>C, and TGFβ 29T>C.
    Lymphat Res Biol 2017 Jul 27. Epub 2017 Jul 27.
    1 Central Clinical Hospital , Ministry of Internal Affairs, Warsaw, Poland .
    Background: Infection is the most common type of complication observed in lymphedema and is promoted by lymphatic system dysfunction, which causes locoregional immune disorders. Infectious complications are primarily bacterial and most commonly cellulitis (dermato-lymphangio-adenitis, DLA) caused by patients' own skin Staphylococci epidermidis and aureus. The clinical course and outcomes in the immune response to infection have been shown to be associated with genetic polymorphisms. Read More

    Diagnosis of Upper-Quadrant Lymphedema Secondary to Cancer: Clinical Practice Guideline From the Oncology Section of APTA.
    Rehabil Oncol 2017 Jul 30;35(3):E1-E18. Epub 2017 Jun 30.
    Doctor of Physical Therapy Program, St Catherine University, Minneapolis, MN.
    Introduction: The Oncology Section of APTA developed a clinical practice guideline to aid the clinician in diagnosing secondary upper-quadrant cancer-related lymphedema.

    Methods: Following a systematic review of published studies and a structured appraisal process, recommendations were written to guide the physical therapist and other health care clinicians in their diagnostic process. Overall, clinical practice recommendations were formulated on the basis of the evidence for each diagnostic method and were assigned a grade based on the strength of the evidence for different patient presentations and clinical utility. Read More

    [Primary congenital lymphedema: Milroy disease: the first case observed in the Department of Pediatrics at the University Hospital Yalgado Ouedraogo, Ouagadougou].
    Pan Afr Med J 2017 9;27:21. Epub 2017 May 9.
    Département de Pédiatrie du CHU Yalgado Ouédraogo de Ouagadougou, Burkina-faso.
    Congenital lymphedema is the accumulation of lymphatic fluid in the child's interstitial spaces. Milroy disease is a rare, hereditary, autosomal dominant condition showing incomplete penetrance. We report the case of a 7-year old little girl with Milroy disease examined for erysipelas on congenital big right leg. Read More

    Acquired Senescent T-Cell Phenotype Correlates with Clinical Severity in GATA Binding Protein 2-Deficient Patients.
    Front Immunol 2017 12;8:802. Epub 2017 Jul 12.
    Servicio de Inmunología, Hospital Universitario 12 de Octubre, Madrid, Spain.
    GATA binding protein 2 (GATA2) deficiency is a rare disorder of hematopoiesis, lymphatics, and immunity caused by spontaneous or autosomal dominant mutations in the GATA2 gene. Clinical manifestations range from neutropenia, lymphedema, deafness, to severe viral and mycobacterial infections, bone marrow failure, and acute myeloid leukemia. Patients also present with monocytopenia, dendritic cell, B- and natural killer (NK)-cell deficiency. Read More

    Abdominoplasty with Lymphatic Microsurgery for Patients with Secondary Lower Extremity Lymphedema.
    Plast Reconstr Surg 2017 Jul 12. Epub 2017 Jul 12.
    1. Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan 2. Division of Plastic and Reconstructive Surgery, Chiba Cancer Center, Chiba, Japan 3. Department of Surgery, Mito Medical Center, Ibaragi-cho, Japan 4. Department of Plastic and Reconstructive Surgery, Kochi Medical School Hospital, Nankoku, Japan.
    Background: Patients with secondary lower extremity lymphedema (LEL) often develop suprapubic lymphedema. We developed a novel surgical method of shaping the lower abdomen and debulking suprapubic lymphedema with simultaneous reconstruction of lymphatic flow in case of LEL.

    Methods: A skin incision in a fleur-de-lis pattern was performed for horizontal and vertical abdominal skin and fat resection. Read More

    The effects of bandaging with an additional pad and taping on secondary arm lymphedema in a patient after mastectomy.
    J Phys Ther Sci 2017 Jul 15;29(7):1272-1275. Epub 2017 Jul 15.
    Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea.
    [Purpose] The purpose of this case study was to determine the effectiveness of bandaging the arm of a patient with secondary lymphedema on the patient's quality of life, arm volume and arm function using an additional pad and taping along with some other standard therapy modalities for lymphedema. [Subjects and Methods] I used a bandage with an additional pad and taping, along with MLD, exercise, and skin care to treat a patient with unilateral breast-cancer-related arm lymphedema who had fibrotic tissue on her lower arm and hand. I made a pad called a "muff" and applied it under tape while using Vodder's technique. Read More

    Risk factors and a prediction model for lower limb lymphedema following lymphadenectomy in gynecologic cancer: a hospital-based retrospective cohort study.
    BMC Womens Health 2017 Jul 25;17(1):50. Epub 2017 Jul 25.
    Department of Obstetrics and Gynecology, Yaizu City Hospital, 1000, Dobara, Yaizu-shi, 425-8505, Japan.
    Background: Lower limb lymphedema (LLL) is a chronic and incapacitating condition afflicting patients who undergo lymphadenectomy for gynecologic cancer. This study aimed to identify risk factors for LLL and to develop a prediction model for its occurrence.

    Methods: Pelvic lymphadenectomy (PLA) with or without para-aortic lymphadenectomy (PALA) was performed on 366 patients with gynecologic malignancies at Yaizu City Hospital between April 2002 and July 2014; we retrospectively analyzed 264 eligible patients. Read More

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