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    Fiddler's neck: A review.
    Ear Nose Throat J 2017 Feb;96(2):76-79
    Department of Otolaryngology, Augusta University Medical Center, Augusta, GA, USA.
    Fiddler's neck is a common dermatologic condition associated with instrument use in violin and viola players. It typically manifests as a submandibular and/or supraclavicular lesion. It is a benign condition, but it may be mistaken for lymphedema or a salivary gland malignancy. Read More

    Nordic Walking and the Isa Method for Breast Cancer Survivors: Effects on Upper Limb Circumferences and Total Body Extracellular Water - a Pilot Study.
    Breast Care (Basel) 2016 Dec 5;11(6):428-431. Epub 2016 Dec 5.
    Department of Medical, Oral and Biotechnological Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Chieti Scalo, Italy.
    Background: The negative side effects of breast cancer treatments can include upper limb lymphoedema. The growing literature indicates that Nordic walking is an effective discipline against several disease symptoms. The aim of this study was to determine whether introduction to Nordic walking alone is effective against total body extracellular water and upper limb circumferences in breast cancer survivors compared to its combination with a series of specifically created exercises (i. Read More

    Systematic Review of Occupational Therapy and Adult Cancer Rehabilitation: Part 1. Impact of Physical Activity and Symptom Management Interventions.
    Am J Occup Ther 2017 Mar/Apr;71(2):7102100030p1-7102100030p11
    Mariana D'Amico, EdD, OTR/L, BCP, FAOTA, is Associate Professor, Department of Occupational Therapy, Nova Southeastern University, Fort Lauderdale, FL.
    This article is the first part of a systematic review of evidence for the effectiveness of cancer rehabilitation interventions within the scope of occupational therapy that address the activity and participation needs of adult cancer survivors. This article focuses on the importance of physical activity and symptom management. Strong evidence supports the use of exercise for cancer-related fatigue and indicates that lymphedema is not exacerbated by exercise. Read More

    Future Research Priorities for Morbidity Control of Lymphedema.
    Indian J Dermatol 2017 Jan-Feb;62(1):33-40
    Institute of Applied Dermatology, Central University of Kerala, Kasaragod, Kerala, India.
    Background: Innovation in the treatment of lower extremity lymphedema has received low priority from the governments and pharmaceutical industry. Advancing lymphedema is irreversible and initiates fibrosis in the dermis, reactive changes in the epidermis and subcutis. Most medical treatments offered for lymphedema are either too demanding with a less than satisfactory response or patients have low concordance due to complex schedules. Read More

    Co-incidence of Turner syndrome and Duchenne muscular dystrophy - an important problem for the clinician.
    Dev Period Med 2016 ;20(4):273-278
    Department of Biology and Genetics, Medical University of Gdańsk.
    Introduction: Turner syndrome is a relatively common chromosomal disorder which affects about one in 2000 live born females. Duchenne muscular dystrophy is an X-linked recessive disorder affecting 1:3600 live born males. Considering the above, the coexistence of these two diseases may occur only anecdotally. Read More

    New diagnostic modalities in the evaluation of lymphedema.
    J Vasc Surg Venous Lymphat Disord 2017 Mar 16;5(2):261-273. Epub 2017 Jan 16.
    The Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at the University of Texas Health Science Center at Houston, Houston, Tex.
    Objective: Currently, lymphedema (LED) is typically diagnosed clinically on the basis of a patient's history and characteristic physical findings. Whereas the diagnosis of LED is sometimes confirmed by lymphoscintigraphy (LSG), the technique is limited in both its ability to identify disease and to guide therapy. Recent advancements provide opportunities for new imaging techniques not only to assist in the diagnosis of LED, based on anatomic changes, but also to assess contractile function and to guide therapeutic intervention. Read More

    Long-term outcome of hematopoietic stem cell transplantation for IL2RG/JAK3 SCID-: a cohort report.
    Blood 2017 Feb 16. Epub 2017 Feb 16.
    Pediatric Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
    Hematopoietic stem cell transplantation (HSCT) cures the T-lymphocyte, B-lymphocyte and Natural Killer (NK) cell differentiation defect in IL2RG/JAK3 SCID. We evaluated long-term clinical features, longitudinal immunoreconstitution, donor chimerism and quality of life (QoL) of IL2RG/JAK3 SCID patients >2 years post-HSCT at our center. Clinical data were collated and patients/families answered PedsQL Generic Core Scale v4. Read More

    Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.
    Blood 2017 Feb 16. Epub 2017 Feb 16.
    Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden;
    Heterozygous GATA2 mutation is associated with immunodeficiency, lymphedema, and myelodysplastic syndrome. Disease presentation is variable, often coinciding with loss of circulating dendritic cells, monocytes, B cells, and NK cells. Nonetheless, in a proportion of patients carrying GATA2 mutation, NK cells persist. Read More

    Reply: Indocyanine Green Lymphography for Lymphedema Screening following Breast Cancer Treatment.
    Plast Reconstr Surg 2017 Feb 14. Epub 2017 Feb 14.
    1. Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan 2. Department of Breast Surgery, Chiba Cancer Center, Chiba, Japan 3. Department of Plastic and Reconstructive Surgery, Chiba Cancer Center, Chiba, Japan.

    Lymphaticovenous Anastomosis Releases the Lower Extremity Lymphedema-associated Pain.
    Plast Reconstr Surg Glob Open 2017 Jan 26;5(1):e1205. Epub 2017 Jan 26.
    Department of Lymphatic and Reconstructive Surgery, Saiseikai Kawaguchi General Hospital, Saitama, Japan; Department of Plastic and Reconstructive Surgery, Tokyo Takanawa Hospital, Tokyo, Japan; Department of Plastic and Reconstructive surgery, Nadogaya Hospital, Chiba, Japan; Department of Clinical Resident, Fujieda Municipal General Hospital, Fujieda, Japan; and Department of Clinical Resident, NTT East Japan Hospital, Tokyo, Japan.
    Background: We investigate the effectiveness of lymphaticovenous anastomosis (LVA) in releasing lymphedema-associated pain.

    Methods: We performed a retrospective analysis. Subjects of this study included lower extremity lymphedema patients who presented persistent and constant degrees of pain in their lower limbs. Read More

    Effect of myofascial techniques for treatment of upper limb dysfunctions in breast cancer survivors: randomized controlled trial.
    Support Care Cancer 2017 Feb 14. Epub 2017 Feb 14.
    Department of Rehabilitation Sciences; Department of Physical Medicine and Rehabilitation , University Hospitals Leuven, KU Leuven - University of Leuven, Herestraat 49, 3000, Leuven, Belgium.
    Purpose: Besides pain, myofascial dysfunctions may contribute to the presence of upper limb impairments such as impaired range of motion, decreased strength, lymphedema, and altered postures and kinematics. Therefore, the aim of this study was to investigate the effect of myofascial therapy in addition to a standard physical therapy program for treatment of upper limb dysfunctions in breast cancer survivors.

    Methods: Fifty women treated for a unilateral breast cancer with pain and myofascial dysfunctions at the upper limb region. Read More

    Histopathology of Bilateral Lower Extremity Inflammatory Lymphedema in Military Basic Trainees: A leukocytoclastic vasculitis of the deep vascular plexus.
    J Cutan Pathol 2017 Feb 14. Epub 2017 Feb 14.
    Dr. McCann is a Dermatology resident and Dr. Dalton is a Dermatopathologist at the San Antonio Uniformed Services Health Education Consortium. Dr. Kobayashi is a Dermatologist/Dermatopathologist in Colorado Springs, Colorado.
    Bilateral lower extremity inflammatory lymphedema (BLEIL) is a recently described condition that presents with exquisite tenderness, erythema, and edema of the lower leg, ankle and dorsal foot resembling an acute cellulitis. It was first reported in healthy, young adult military basic trainees with a normal body mass index during the first 72 hours of arrival to basic training. It occurs while standing at attention for many hours, and shows rapid resolution with elevation and rest. Read More


    Labia Majora Share.
    Arch Plast Surg 2017 Jan 20;44(1):80-84. Epub 2017 Jan 20.
    Division of Plastic, Reconstructive and Aesthetic Surgery, Department of General Surgery, National University Health System, Singapore.
    Defects involving specialised areas with characteristic anatomical features, such as the nipple, upper eyelid, and lip, benefit greatly from the use of sharing procedures. The vulva, a complex 3-dimensional structure, can also be reconstructed through a sharing procedure drawing upon the contralateral vulva. In this report, we present the interesting case of a patient with chronic, massive, localised lymphedema of her left labia majora that was resected in 2011. Read More

    De Novo Upper Extremity Lymphedema After Elective Hand Surgery in Breast Cancer Survivors.
    Ann Plast Surg 2017 Feb 10. Epub 2017 Feb 10.
    From the Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.
    Background: The safety of elective hand surgery in breast cancer (BC) survivors is controversial because of concerns of developing upper extremity lymphedema. This study aimed to evaluate the risk of developing lymphedema after elective hand surgery among patients that underwent ipsilateral axillary lymph node dissection (ALND), sentinel lymph node biopsy (SLNB), and/or radiation therapy (RT).

    Method: A retrospective cohort of BC patients treated with ALND, SLNB, and/or RT was identified (1997-2012). Read More

    Topical tacrolimus for the treatment of secondary lymphedema.
    Nat Commun 2017 Feb 10;8:14345. Epub 2017 Feb 10.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center New York, New York, New York 10065, USA.
    Secondary lymphedema, a life-long complication of cancer treatment, currently has no cure. Lymphedema patients have decreased quality of life and recurrent infections with treatments limited to palliative measures. Accumulating evidence indicates that T cells play a key role in the pathology of lymphedema by promoting tissue fibrosis and inhibiting lymphangiogenesis. Read More

    [Lymphoedema Following Regional Lymph Node Surgery for Breast Cancer].
    Klin Onkol 2017 ;30(1):34-40
    Background: The treatment of breast cancer is based on the multimodal principle and surgery of regional lymph nodes is an inseparable part of this. Indication criteria are changing constantly folowing advances in other modalities. It is necessary to consider not only the diagnostic or therapeutic benefit but also to take into account adverse effects. Read More

    Erratum to: Radiation therapy targets and the risk of breast cancer-related lymphedema: a systematic review and network meta-analysis.
    Breast Cancer Res Treat 2017 Feb 9. Epub 2017 Feb 9.
    Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1484, Houston, TX, 77030, USA.

    Acute Truncal Lymphedema Secondary to Axillary Metastatic Melanoma Presenting Like Cellulitis.
    Case Rep Med 2017 15;2017:5462929. Epub 2017 Jan 15.
    Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.
    There are reported cases of diphencyprone used in treating cutaneous metastases of melanoma. Here, we report a patient with previous primary melanoma on his left back treated with surgical excision and lymphadenectomy, followed by radiotherapy for the recurrent tumor on the primary site. Despite radiotherapy and treatment with dabrafenib and trametinib, in-transit metastases have developed and topical diphencyprone was applied to these metastases. Read More

    The upper-limb volumetric changes in breast cancer survivors with axillary web syndrome.
    Eur J Cancer Care (Engl) 2017 Feb 9. Epub 2017 Feb 9.
    Department of Sports, Health, and Leisure, Tatung Institute of Technology, Chiayi City, Taiwan.
    Whether upper-limb swelling is associated with axillary web syndrome (AWS) is unknown. We recruited unilateral breast cancer (BC) patients who were scheduled for surgical intervention and lymph node dissection. The pre-operative assessment and post-operative assessment 3-4 weeks after surgery evaluated the upper-limb circumferential measurements, segmental limb volume, pain scores, grasp, shoulder range of motion (ROM), shoulder muscle power and quality-of-life scores. Read More

    Gross-dependent lower limb lymphoedema.
    Clin Case Rep 2017 Feb 19;5(2):150-153. Epub 2017 Jan 19.
    Department of General & Vascular Surgery Mercy University Hospital Cork Ireland.
    Gross-dependent lower limb lymphoedema is an unusual condition which can be painful particularly if ulceration occurs. Focused history and clinical examination in addition to appropriate radiological investigation aid in the diagnosis. It is difficult to treat and requires a multidisciplinary team including vascular surgeons, dermatologists and clinical nurse specialists. Read More

    Effects of proprioceptive neuromuscular facilitation stretching and deep-breathing exercises on upper extremity lymphedema in stroke patients.
    J Phys Ther Sci 2016 Dec 27;28(12):3276-3278. Epub 2016 Dec 27.
    Department of Physical Therapy, Sangji University, Republic of Korea.
    [Purpose] The purpose of this study was to determine the effects of deep-breathing and proprioceptive neuromuscular facilitation stretching exercises on upper limb lymphedema in stroke patients. [Subjects and Methods] The study consisted of 10 patients with lymphedema that had occurred after stroke. Neurodevelopmental treatment was applied in the same manner as that used for the existing treatment. Read More

    Socio-ecological dynamics and challenges to the governance of Neglected Tropical Disease control.
    Infect Dis Poverty 2017 Feb 6;6(1):35. Epub 2017 Feb 6.
    Department of International Development, London School of Economics and Political Science, London, UK.
    The current global attempts to control the so-called "Neglected Tropical Diseases (NTDs)" have the potential to significantly reduce the morbidity suffered by some of the world's poorest communities. However, the governance of these control programmes is driven by a managerial rationality that assumes predictability of proposed interventions, and which thus primarily seeks to improve the cost-effectiveness of implementation by measuring performance in terms of pre-determined outputs. Here, we argue that this approach has reinforced the narrow normal-science model for controlling parasitic diseases, and in doing so fails to address the complex dynamics, uncertainty and socio-ecological context-specificity that invariably underlie parasite transmission. Read More

    Successful Treatment of Classic Kaposi Sarcoma With Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet (Nd: YAG) Laser: A Preliminary Study.
    Dermatol Surg 2017 Feb 1. Epub 2017 Feb 1.
    *Both authors are affiliated with the Department of Dermatology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
    Background: Kaposi sarcoma (KS) is a systemic disease that can present with cutaneous lesions with or without internal involvement, mostly caused by infection with human herpesvirus-8. The treatment options include surgical excision, cryotherapy, radiotherapy, intralesional chemotherapy, laser, and elastic stockings for the prevention of lymphedema.

    Objective: This article presents 7 cases with classic KS treated with the long-pulse neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Read More

    Lymph Drainage During Wound Healing in a Hindlimb Lymphedema Mouse Model.
    Lymphat Res Biol 2017 Feb 2. Epub 2017 Feb 2.
    3 Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa, Japan .
    Background: Although lymphedematous skin exhibits delayed wound healing, little is known about lymph drainage during wound healing. We investigated the wound healing process in the presence of lymphatic dysfunction.

    Methods And Results: The right inguinal lymph nodes (iLNs) and the surrounding tissue were excised in each mouse (the operation side), and a sham operation was performed in the left hindlimb (the control side). Read More

    Four cases of Morbihan disease successfully treated with doxycycline.
    J Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Dermatology, Kitakami Saiseikai Hospital, Kitakami, Japan.
    Morbihan disease (MD) is rosacea-like disease characterized by persistent lymphedema on the upper half of the face. Currently, there is no established standard treatment for MD. Recently, MD has been reported to be associated with the infiltration of mast cells. Read More

    Comparisons Between Cancer-Related and Noncancer-Related Lymphedema: An Overview of New Patients Referred to a Specialized Hospital-Based Center in Canada.
    Lymphat Res Biol 2017 Jan 30. Epub 2017 Jan 30.
    1 Lymphedema Program, McGill University Health Centre , Montréal, Canada .
    Background: Lymphedema is an irreversible inflammatory condition caused by accumulated lymph fluid and is associated with chronic swelling and increased risk of cellulitis. Our objectives were to: (1) describe the patient population referred to a Canadian lymphedema center and (2) compare lymphedema characteristics between patients with cancer and patients with noncancer diagnoses.

    Methods And Results: A retrospective cohort study was conducted of new patients referred for suspected lymphedema to a hospital-based center over a 2-year period. Read More

    Prefabricated Cervical Skin Flaps for Hemi-Facial Resurfacing: Elucidating the Natural History of Postoperative Edema Using Indocyanine Green.
    Lymphat Res Biol 2017 Jan 30. Epub 2017 Jan 30.
    1 Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine , Shanghai, China .
    Background: The increases in capillary wall permeability and capillary hydrostatic pressure are considered to be the causes for the acute swelling seen in flaps; however, disruption of the circulating flap lymphatics could be another contributory factor. In this study we monitor the development of flap edema in a series of 18 prefabricated flaps and aim to delineate the natural history of this phenomenon by use of lymphography.

    Methods: Postoperative swelling was monitored in a series of 18 pre-expanded prefabricated cervical skin flaps used for hemi-facial burns-scar resurfacing. Read More

    SF-36 Shows Increased Quality of Life Following Complete Reduction of Postmastectomy Lymphedema with Liposuction.
    Lymphat Res Biol 2017 Jan 30. Epub 2017 Jan 30.
    1 Department of Clinical Sciences in Malmö, Lund University , Malmö, Sweden .
    Abstracts Background: Arm lymphedema after breast cancer surgery affects women both from physical and psychological points of view. Lymphedema leads to adipose tissue deposition. Liposuction and controlled compression therapy (CCT) reduces the lymphedema completely. Read More

    [Effectiveness of Postoperative Physical Therapy for Upper-Limb Impairments after Breast Cancer Treatment].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1458-1460
    Dept. of Surgery, Kansai Medical University.
    Previous studies have reported the benefits of beginning rehabilitation immediately after breast cancer surgery for improving motor function. However, most studies have not evaluated the long-term struggles patients face after hospital discharge in resuming their previous activities and socialparticipation. Furthermore, the intervention methods and effects of rehabilitation for such activities have not been evaluated. Read More

    Computed tomography lymphangiography findings in 27 cases of lymphangioleiomyomatosis.
    Acta Radiol 2017 Jan 1:284185116688381. Epub 2017 Jan 1.
    1 Department of Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, PR China.
    Background Lymphangioleiomyomatosis (LAM) is a rare disease involving the bronchi, lymphatic vessels, and veins. However, there are few reports about lymphatic vessel abnormalities associated with LAM. Purpose To evaluate computed tomography (CT) lymphangiography findings in cases of LAM, especially lymphatic vessel abnormalities. Read More

    The lymphatic vasculature revisited-new developments in the zebrafish.
    Methods Cell Biol 2017 29;138:221-238. Epub 2016 Dec 29.
    Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster, Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC M 1003-CiM), University of Münster, Münster, Germany.
    The lymphatic system is lined by endothelial cells and part of the vasculature. It is essential for tissue fluid homeostasis, absorption of dietary fats, and immune surveillance in vertebrates. Misregulation of lymphatic vessel formation and dysfunction of the lymphatic system have been indicated in a number of pathological conditions including lymphedema formation, obesity or chronic inflammatory diseases such as rheumatoid arthritis. Read More

    Seroma indicates increased risk of lymphedema following breast cancer treatment: A retrospective cohort study.
    Breast 2017 Jan 24;32:102-104. Epub 2017 Jan 24.
    Department of Plastic Surgery, Odense University Hospital, Denmark.
    Introduction: Lymphedema is one of the most serious complications following breast cancer treatment. While many risk factors are well described the role of seroma formation has recently produced mixed results. Therefore, we aimed to evaluate if seroma is a risk factor for development of lymphedema in one of the largest retrospective cohort studies. Read More

    Animal Models of Secondary Lymphedema: New Approaches in the Search for Therapeutic Options.
    Lymphat Res Biol 2017 Jan 27. Epub 2017 Jan 27.
    Department of General and Visceral Surgery, University Hospital Münster , Münster, Germany .
    Secondary lymphedema is still a worldwide problem. Symptomatic approaches to lymphedema therapy have been mainly used, with complete decongestive therapy as the cornerstone. Due to a lack of regenerative therapy, researchers have established various animal models to obtain insights into pathomechanisms and to reveal the best therapeutic option. Read More

    Lymphedema and employability - Review and results of a survey of Austrian experts.
    Wien Klin Wochenschr 2017 Jan 26. Epub 2017 Jan 26.
    Department of Physical Medicine and Rehabilitation, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
    Background: Literature about lymphedema and its influence on the ability to work and employability is limited. The aim of the present study was to investigate the opinion of Austrian experts on factors influencing the ability to work and employability in patients suffering from lymphedema.

    Methods: A self-administered questionnaire consisting of 6 questions was sent to 12 Austrian lymphedema experts with 6 different specializations from May to August 2016. Read More

    Efficacy and safety of far infrared radiation in lymphedema treatment: clinical evaluation and laboratory analysis.
    Lasers Med Sci 2017 Jan 26. Epub 2017 Jan 26.
    Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
    Swelling is the most common symptom of extremities lymphedema. Clinical evaluation and laboratory analysis were conducted after far infrared radiation (FIR) treatment on the main four components of lymphedema: fluid, fat, protein, and hyaluronan. Far infrared radiation is a kind of hyperthermia therapy with several and additional benefits as well as promoting microcirculation flow and improving collateral lymph circumfluence. Read More

    Clinical Inquiry-In women who have undergone breast cancer surgery, including lymph node removal, do blood pressure measurements taken in the ipsilateral arm increase the risk of lymphedema?
    J Okla State Med Assoc 2016 Nov;109(11):529-531
    Beaumont - Royal Oak Plastic & Reconstructive Surgery.
    Throughout the healthcare industry fears of taking blood pressure in the arm of patients who have undergone breast cancer surgery have been propagated for decades and continue to be recommended by multiple medical societies and healthcare organizations. However, these precautions are not well based on evidence-based medicine and may have a more historical and traditional basis. The purpose of this study was to review current evidence-based research as well as current guidelines regarding ipsilateral arm blood pressure measurements in women who have undergone breast surgery for cancer including lymph node removal. Read More

    Hypofractionated Regional Nodal Irradiation for Women With Node-Positive Breast Cancer.
    Int J Radiat Oncol Biol Phys 2017 Mar 15;97(3):563-570. Epub 2016 Nov 15.
    Department of Radiotherapy, National Institute of Oncology, Mohammed V University, Rabat, Morocco.
    Purpose: To evaluate the effect of hypofractionated radiation therapy (HFRT) of the breast/chest wall and regional nodes on overall survival (OS), disease-free survival (DFS), locoregional control and on treatment-related toxicity in patients with breast cancer and nodal involvement.

    Methods And Materials: Two hundred fifty-seven patients treated between October 2009 and June 2011 with hypofractionated locoregional radiation therapy (42 Gy in 15 fractions) were retrospectively reviewed, 51 (19.8%) after breast-conserving surgery and 206 (80. Read More

    The Lymphatic Response to Injury with Soft-Tissue Reconstruction in High-Energy Open Tibial Fractures of the Lower Extremity.
    Plast Reconstr Surg 2017 Feb;139(2):483-491
    Adelaide, South Australia, and Sydney, New South Wales, AustraliaFrom the Department of Surgery, Lymphoedema Research Unit, Flinders University; the Department of Plastic and Reconstructive Surgery, Royal Adelaide Hospital; and the Faculty of Medicine and Health Sciences, Macquarie University.
    Background: Severe compound tibial fractures are associated with extensive soft-tissue damage, resulting in disruption of lymphatic pathways that leave the patient at risk of developing chronic lymphedema. There are limited data on lymphatic response following lower limb trauma. Indocyanine green fluorescence lymphography is a novel, real-time imaging technique for superficial lymphatic mapping. Read More

    Electrochemotherapy in the treatment of metastatic malignant melanoma: A prospective cohort study by InspECT.
    Br J Dermatol 2017 Jan 24. Epub 2017 Jan 24.
    Department of Plastic Surgery, St. Georges Hospital, London, United Kingdom.
    Background: Electrochemotherapy (ECT) is an effective local treatment for cutaneous metastasis. Treatment involves the administration of chemotherapeutic drugs followed by delivery of electrical pulses to the tumour. The aim of this study was to investigate the effectiveness of ECT in cutaneous metastases of melanoma and to identify factors which affect (beneficially or adversely) the outcome. Read More

    Cost-effectiveness of sentinel node biopsy and pathological ultrastaging in patients with early-stage cervical cancer.
    Cancer 2017 Jan 24. Epub 2017 Jan 24.
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
    Background: The objective of this study was to determine the cost-effectiveness of radical hysterectomy (RH) and sentinel lymph node biopsy (SLNB) for the management of early-stage cervical cancer (stage IA2-IB1).

    Methods: A simple decision tree model was developed to follow a simulated cohort of patients with early-stage cervical cancer treated with RH and 1 of 3 lymph node assessment strategies: systematic pelvic lymph node dissection (PLND), SLNB using technetium 99 (Tc99) and blue dye, and SLNB using Tc99 only. SLNB using indocyanine green (ICG) was used as an exploratory strategy. Read More

    Ultrasonographic Evaluation of Breast Cancer-related Lymphedema.
    J Vis Exp 2017 Jan 12(119). Epub 2017 Jan 12.
    Department of Rehabilitation Medicine, Chungnam National University Hospital (CNUH);
    Lymphedema is one of the most common complications after breast cancer surgery. There are many diagnostic tools for lymphedema, but no standard method yet exists. Progressive Resistance Exercise (PRE) is expected to improve lymphedema without additional swelling. Read More

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