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    Enhancement of Lymphatic Vessels in the Superficial Layer in a Rat Model of a Lymphedematous Response.
    Plast Reconstr Surg Glob Open 2018 May 25;6(5):e1770. Epub 2018 May 25.
    Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.
    Background: The morphologic and histologic behavior of lymphatic vessels in lymphedema has not been well analyzed using laboratory animals. The purpose of the present study was to elucidate the regeneration process of lymphatic vessels after acute lymphedema in a rat model.

    Methods: The acute lymphedema was induced by an amputation and a replantation surgery on a rat hind limb. Read More

    The Chimeric Versatility of the Subscapular System Revisited: Backup Options, Coverage for Bone Transplants and Vascularized Lymph Nodes.
    Plast Reconstr Surg Glob Open 2018 May 15;6(5):e1765. Epub 2018 May 15.
    Department of Hand-, Plastic- and Reconstructive Surgery, Burn Center - BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Germany.
    Traumatic soft tissue and bone defects are demanding challenges for the reconstructive microsurgeons. Common and safe workhorses for these reconstructions are free microvascular flaps based on the subscapular system. In this article, we want to demonstrate the versatility of the serratus anterior muscle combined with other components of the subscapular system for reconstruction of complex lower extremity defects. Read More

    The importance of indocyanine green near-infrared fluorescence angiography in perfusion assessment in vascularized omentum lymphatic transplant.
    J Surg Oncol 2018 Jun 19. Epub 2018 Jun 19.
    Department of Surgery, Division of Plastic Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
    Background And Objective: Vascularized omentum lymphatic transplant (VOLT) for treatment of lymphedema has become popular because of no risk of iatrogenic lymphedema and abundant lymphatic tissue. However, perfusion to the omentum can be difficult to assess clinically. The purpose of this study was to clarify the incidence and degree of ischemia in the omentum. Read More

    Assessment and management of older people with venous leg ulcers.
    Nurs Older People 2018 Jun 19. Epub 2018 Jun 19.
    Specialist Lymphoedema Clinic, NHS Greater Glasgow and Clyde, Glasgow, Scotland.
    A venous leg ulcer (VLU) is defined as the loss of skin below the knee on the leg or foot in the presence of venous disease, which takes more than two weeks to heal. The prevalence of VLUs is increasing, especially in older people, which will increase the demand for nursing care. Development of a lower leg ulcer should trigger immediate assessment of risk factors for chronic venous disease followed by action to identify the cause and initiate treatment, which should prevent progression to more complex and chronic problems. Read More

    Information technology in morbidity management of human lymphatic filariasis-A promising tool in global programme for elimination of lymphatic filariasis.
    J Vector Borne Dis 2018 Jan-Mar;55(1):20-25
    Vellore Institute of Technology, Vellore, Tamil Nadu, India.
    Background & Objectives: India is a signatory to the 1997 World Health Assembly resolutions on lymphatic fila- riasis, and other neglected tropical diseases, and supports global elimination of lymphatic filariasis by 2020. The global programme to eliminate lymphatic filariasis (GPELF) has two main components, viz. interrupting transmission of LF through mass drug administration; and managing morbidity and preventing disability. Read More

    Health and economic benefits of advanced pneumatic compression devices in patients with phlebolymphedema.
    J Vasc Surg 2018 Jun 15. Epub 2018 Jun 15.
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, Calif. Electronic address:
    Objective: Phlebolymphedema (chronic venous insufficiency-related lymphedema) is a common and costly condition. Nevertheless, there is a dearth of evidence comparing phlebolymphedema therapeutic interventions. This study sought to examine the medical resource utilization and phlebolymphedema-related cost associated with Flexitouch (FLX; Tactile Medical, Minneapolis, Minn) advanced pneumatic compression devices (APCDs) relative to conservative therapy (CONS) alone, simple pneumatic compression devices (SPCDs), and other APCDs in a representative U. Read More

    Stem Cell Therapy Using Bone Marrow-Derived Mononuclear Cells in Treatment of Lower Limb Lymphedema: A Randomized Controlled Clinical Trial.
    Lymphat Res Biol 2018 Jun;16(3):270-277
    4 Haematology Unit, Internal Medicine Department, Faculty of Medicine, Tanta University , Tanta, Egypt .
    Background: Up till now, there is no satisfactory treatment for lymphedema. The aim of this study is to evaluate stem cell therapy in lymphedema.

    Methods And Results: This prospective randomized study includes 40 patients with chronic lymphedema divided randomly into two groups: group I (stem cell therapy group) and group II (control group). Read More

    Supplementation with Robuvit® in post-mastectomy post-radiation arm lymphedema.
    Minerva Chir 2018 Jun;73(3):288-294
    IRVINE3 Labs, CH-PE University, Chieti, Italy.
    Background: Post-mastectomy lymphedema is one of the most significant, non-life-threatening complications following breast cancer surgery and radiotherapy. Post-mastectomy post-radiotherapy (PMPR) lymphedema is related to damages to lymphatics and/or veins during/after axillary surgery and radiotherapy. The management of this condition is very challenging; the comprehensive decongestive therapy (CTD), which combines physiotherapy, self-management, and hygiene, and is currently considered the standard management (SM). Read More

    Rare Variants in LAMA5 Gene associated with FLT4 and FOXC2 Mutations in Primary Lymphedema May Contribute to Severity.
    Lymphology 2016 Dec;49(4):192-204
    Mutations in the Fms-related tyrosine kinase 4 (FLT4) and forkhead box protein C2 (FOXC2) genes cause Milroy disease (MD) and lymphedema-distichiasis syndrome (LDS), respectively, but the mechanism underlying disease pathology remains unclear. Applying whole-exome sequencing to two families with MD, one LDS family, and one sporadic LDS case, we identified four rare variants in the laminin subunit alpha-5 gene (LAMA5) in subjects carrying novel and known missense FLT4 mutations and a 7-bp duplication and 1-bp insertion in FOXC2. Phenotyping was expanded in some individuals using magnetic resonance lymphangiography, indiocyanine green fluorescence lymphography, and immunofluorescent lymphatic staining of skin tissue. Read More

    The Diagnosis and Treatment of Peripheral Lymphedema: 2016 Consensus Document of the International Society of Lymphology.
    • Authors:
    Lymphology 2016 Dec;49(4):170-84
    This International Society of Lymphology (ISL) Consensus Document is the latest revision of the 1995 Document for the evaluation and management of peripheral lymphedema (1). It is based upon modifications: [A] suggested and published following the 1997 XVI International Congress of Lymphology (ICL) in Madrid, Spain (2), discussed at the 1999 XVII ICL in Chennai, India (3), and considered/ confirmed at the 2000 (ISL) Executive Committee meeting in Hinterzarten, Germany (4); [B] derived from integration of discussions and written comments obtained during and following the 2001 XVIII ICL in Genoa, Italy as modified at the 2003 ISL Executive Committee meeting in Cordoba, Argentina (5); [C] suggested from comments, criticisms, and rebuttals as published in the December 2004 issue of Lymphology (6); [D] discussed in both the 2005 XX ICL in Salvador, Brazil and the 2007 XXI ICL in Shanghai, China and modified at the 2008 Executive Committee meeting in Naples, Italy (7,8);[E] modified from discussions and written comments from the 2009 XXII ICL in Sydney, Australia, the 2011 XXIII ICL in Malmö, Sweden, the 2012 Executive Committee Meetings (9),and [F] from discussions at the 2013 XXIV ICL in Rome, Italy, and the 2015 XXV ICL in San Francisco, USA, as well as multiple written comments and feedback from Executive Committee and other ISL members during the 2016 drafting. The document attempts to amalgamate the broad spectrum of protocols and practices advocated worldwide for the diagnosis and treatment of peripheral lymphedema into a coordinated proclamation representing a “Consensus” of the international community based on various levels of evidence. Read More

    Lymphedema secondary to limited cutaneous systemic sclerosis.
    BMJ Case Rep 2018 Jun 15;2018. Epub 2018 Jun 15.
    Internal Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
    Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by vascular abnormalities, immune system activation and fibrosis. Lymphatic involvement in SSc was described more recently and starts in early stages. This report describes a 46-year-old patient who developed over the last 2 years asymmetric lymphedema in lower extremities. Read More

    Mobiderm Autofit: an adjustable sleeve that enables patients to self-manage lymphoedema.
    Br J Community Nurs 2018 Apr;23(Sup4):S22-S28
    (case study author), Lymphoedema Clinical Nurse Manager, Wolverhampton Lymphoedema Service, Compton Hospice; Honorary Lecturer, University of Wolverhampton; and trainer at Lymphoedema Training Academy.
    Lymphoedema can result in debilitating physical and psychosocial morbidity and when combined with other chronic comorbidity, often requires holistic, specialist management that encompasses all the complex and compounding problems. Self-care is an integral component of any treatment strategy, however, the patient must be fully prepared and ongoing support should be provided. Self-care consists of managing the symptoms of lymphoedema but should include other fundamental aspects of healthy living, for example, maintaining a healthy weight and activity levels. Read More

    The impact of chronic oedema on quality of life in the elderly.
    Br J Community Nurs 2018 Apr;23(Sup4):S10-S12
    Lecturer in adult nursing, Birmingham City University and clinical nurse specialist in lymphoedema, Walsall Healthcare NHS Trust.
    Quality of life (QoL) is a concept that is relevant for everyone, but individuals experience factors that make up QoL differently. This article considers the impact chronic oedema has on older people's QoL. There are additional challenges in this group, such as the ageing process, which interlink with QoL. Read More

    Development of Low-Cost Locally Sourced Two-Component Compression Bandages in Western Kenya.
    Dermatol Ther (Heidelb) 2018 Jun 15. Epub 2018 Jun 15.
    Academic Model Providing Access To Healthcare (AMPATH), Eldoret, Kenya.
    Introduction: Compression therapy is well-established standard of care for chronic leg ulcers from venous disease and lymphedema. Chronic leg ulcers and lymphedema have a significant impact on quality of life, driven by pain, foul odor, and restricted mobility. Provision of layered compression therapy in resource-limited settings, as in Western Kenya and other regions of sub-Saharan Africa, is a major challenge due to several barriers: availability, affordability, and access to healthcare facilities. Read More

    Rehabilitation for cancer survivors: How we can reduce the healthcare service inequality in low- and middle income countries.
    Am J Phys Med Rehabil 2018 Jun 13. Epub 2018 Jun 13.
    Graduate Program, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
    Cancer diagnosis often substantially affects patient's physical, psychological, and emotional status. The majority of cancer patients experience declining of energy, activity levels, social-cultural participation and relationships. In addition, cancer progression and side effects of aggressive cancer treatment often cause debilitating pain, fatigue, weakness, joint stiffness, depression, emotional instability, limited mobility, poor nutritional status, skin breakdown, bowel dysfunction, swallowing difficulty, and lymphedema leading into functional impairment and disability that can be addressed through rehabilitation care. Read More

    Acute scrotum: Hansen's disease versus filariasis.
    Int J Mycobacteriol 2018 Apr-Jun;7(2):195-197
    Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.
    Hansen's disease is caused by Mycobacterium leprae. The disease is known to involve the visceral organs including the testis apart from the skin and nerves in the lepromatous pole of leprosy due to widespread hematogenous dissemination of lepra bacilli. Furthermore, there can be testicular pain during the type 2 reaction in Hansen's disease. Read More

    Low-stretch bandages to treat primary lower limb lymphoedema: a cohort of 48 children.
    Br J Dermatol 2018 Jun 13. Epub 2018 Jun 13.
    Department of Lymphology, Centre National de Référence des Maladies Vasculaires Rares (Lymphoedèmes Primaires), Hôpital Cognacq-Jay, 15, rue Eugène-Millon, 75015, Paris, France.
    Primary childhood lymphoedema is a rare disorder, attributed to constitutional lymphatic system abnormality(ies), with familial, syndromic and nonsyndromic forms, associated or not with known gene mutation(s). Lymphoedema treatment for adults is based on complete decongestive physiotherapy, comprised of an initial intensive phase, to reduce volume that includes low-stretch bandaging, manual lymph drainage, exercises and skin care, followed by a maintenance phase, essentially based on wearing an elastic garment. Recommendations addressing upper limb lymphoedema after breast cancer, exclusively for adult women, were extrapolated to primary lymphoedema. Read More

    A novel mutation in the conserved sequence of vascular endothelial growth factor receptor 3 leads to primary lymphoedema.
    J Int Med Res 2018 Jan 1:300060518773264. Epub 2018 Jan 1.
    2 Department of Microsurgery, Trauma and Hand Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
    Objective To investigate whether lymphoedema in a Chinese family showed the hereditary and clinical characteristics of Milroy disease, an autosomal dominant form of congenital lymphoedema, typically characterized by chronic lower limb tissue swelling due to abnormal lymphatic vasculature development, and to perform mutational analyses of vascular endothelial growth factor receptor ( VEGFR)3. Methods Individuals from a three-generation family affected by congenital lymphoedema were clinically assessed for Milroy disease. Mutation analysis of VEGFR3 was performed using DNA from family members and healthy controls. Read More

    Lymphedema techniques to manage edema after SCI: a retrospective analysis.
    Spinal Cord 2018 Jun 12. Epub 2018 Jun 12.
    Crawford Research Institute, Shepherd Center, Atlanta, Georgia.
    Study Design: Retrospective analysis of treatment data for a cohort of clients with spinal cord injury (SCI) who received therapy for management of edema.

    Objective: To evaluate the safety, feasibility, and benefit of a modified lymphedema treatment approach for treatment of chronic lower extremity edema in persons with SCI.

    Setting: A specialty rehabilitation hospital in Atlanta, GA, USA. Read More

    Three Lymphadenectomy Strategies in Low-Risk Endometrial Carcinoma: A Cost-Effectiveness Analysis.
    Obstet Gynecol 2018 Jun 6. Epub 2018 Jun 6.
    Division of Surgery, Department of Gynecologic Oncology and Reproductive Medicine, and the Department of Health Services Research, the University of Texas MD Anderson Cancer Center, Houston, Texas; and the Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota.
    Objective: To evaluate the cost-utility of three lymphadenectomy strategies in the management of low-risk endometrial carcinoma.

    Methods: A decision analysis model compared three lymphadenectomy strategies in women undergoing minimally invasive surgery for low-risk endometrial carcinoma: 1) routine lymphadenectomy in all patients, 2) selective lymphadenectomy based on intraoperative frozen section criteria, and 3) sentinel lymph node mapping. Costs and outcomes were obtained from published literature and Medicare reimbursement rates. Read More

    Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline.
    J Clin Oncol 2018 Jun 11:JCO2018792721. Epub 2018 Jun 11.
    Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA; Kari Bohlke, American Society of Clinical Oncology, Alexandria, VA; Ting Bao and Gary E. Deng, Memorial Sloan Kettering Cancer Center; Dawn L. Hershman, Columbia University Medical Center, New York; Karen M. Mustian, University of Rochester Medical Center, Rochester, NY; Angela M. DeMichele, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Judith M. Fouladbakhsh, Oakland University, Rochester, MI; Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA; Sami Mansfield, Cancer Wellness for Life, Shawnee, KS; Sarah Cannon Cancer Institute, Kansas City, MO; Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL; Erin Price, Smith Center for Healing and the Arts, Washington, DC; Susan Rafte, Houston, TX; and Lorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
    Purpose The Society for Integrative Oncology (SIO) produced an evidence-based guideline on use of integrative therapies during and after breast cancer treatment that was determined to be relevant to the American Society of Clinical Oncology (ASCO) membership. ASCO considered the guideline for endorsement. Methods The SIO guideline addressed the use of integrative therapies for the management of symptoms and adverse effects, such as anxiety and stress, mood disorders, fatigue, quality of life, chemotherapy-induced nausea and vomiting, lymphedema, chemotherapy-induced peripheral neuropathy, pain, and sleep disturbance. Read More

    Physical Activity, Exercise and Breast Cancer - What Is the Evidence for Rehabilitation, Aftercare, and Survival? A Review.
    Breast Care (Basel) 2018 Apr 11;13(2):93-101. Epub 2018 Apr 11.
    Department I of Internal Medicine, Center of Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, Germany.
    The current scientific field of exercise interventions in breast cancer is very large. Rehabilitation focuses on restoring or improving quality of life and thus on independence and participation in life. Hence, it is important to investigate exercise interventions in the setting of rehabilitation and aftercare. Read More

    Unilateral upper extremity lymphedema in metastatic prostate cancer.
    Clin Case Rep 2018 Jun 10;6(6):1014-1019. Epub 2018 Apr 10.
    Memorial Sloan Kettering Cancer Center New York City New York.
    Upper extremity lymphedema and cutaneous spread are atypical behavior of prostate disease and should be kept in the differential for selected patients. This presentation in these patients may be underdiagnosed and potentially an ominous sign. Our case adds to our continued learning of possible prostate malignancy behavior. Read More

    [Elephantiasis of the left lower limb].
    Pan Afr Med J 2018 31;29:95. Epub 2018 Jan 31.
    Service de Dermatologie, Hôpital Militaire d'Instruction Mohamed V, Rabat, Maroc.
    We report the case of a 48-year old female patient with a pathological history of chronic venous insufficiency which required a surgical treatment 5 years before, presenting in the Department of Dermatology with increased left lower limb evolved over the past 4 years. Clinical examination showed increased lower limb, compared to the contralateral limb, with surgical scar at the level of the external face of the left leg and some papillomatous lesions involving the entire left foot and covering the five left toes. The diagnosis of post-traumatic lymphedema (post-surgical) was retained. Read More

    An Assessment of the Relationship Between Abdominal Obesity and the Severity of Upper Extremity Lymphedema.
    Lymphat Res Biol 2018 Jun 5. Epub 2018 Jun 5.
    5 Department of Orthopaedic Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital , Busan, Republic of Korea.
    Background: Obesity is one of the well-known initiating and aggravating factors of lymphedema. Body mass index (BMI) is typically used to define obesity, but in Asian populations, health risks are elevated at lower BMI levels, and abdominal fat may be a better obesity metric. Thus, we assessed the potential association between abdominal obesity and lymphedema severity in postoperative breast cancer patients. Read More

    Multidisciplinary Management of the Axilla in Patients with cT1-T2 N0 Breast Cancer Undergoing Primary Mastectomy: Results from a Prospective Single-Institution Series.
    Ann Surg Oncol 2018 Jun 4. Epub 2018 Jun 4.
    Breast Surgical Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA.
    Background: The after mapping of the axilla: radiotherapy or surgery (AMAROS) trial concluded that for patients with cT1-2 N0 breast cancer and one or two positive sentinel lymph nodes (SLNs), axillary radiotherapy (AxRT) provides equivalent locoregional control and a lower incidence of lymphedema compared with axillary lymph node dissection (ALND). The study prospectively assessed how often ALND could be replaced by AxRT in a consecutive cohort of patients undergoing mastectomy for cT1-2 N0 breast cancer.

    Methods: In November 2015, our multidisciplinary group agreed to omit routine intraoperative SLN evaluation for cT1-2 N0 patients undergoing upfront mastectomy and potentially eligible for postmastectomy radiation therapy (PMRT), including those 60 years of age or younger and those older than 60 years with high-risk features. Read More

    Prenatal thoraco-amniotic chest drain insertion to manage a case of fetal hydrops secondary to .
    BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.
    Fetal Medicine Centre, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
    Lymphoedema-distichiasis is an inherited autosomal dominant disorder of the lymphatic system. Rarely, it is associated with fetal hydrops; the risk and severity of which increases with successive generations. The causative gene is a member of the forkhead transcription factor family (). Read More

    Ionizing Radiation Enhances Paracellular Permeability Through Alteration of Intercellular Junctions in Cultured Human Lymphatic Endothelial Cells.
    Lymphat Res Biol 2018 Jun 4. Epub 2018 Jun 4.
    1 Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine , Kobe, Japan .
    Background: A problematic complication after radiation therapy is lymphedema. Development of lymphedema is associated with an increase in lymphatic paracellular permeability. The current study investigated the effects of radiation on intercellular junctions and paracellular permeability in cultured human dermal lymphatic endothelial cells (HDLECs). Read More

    Reference Values for Assessing Localized Hand Lymphedema Using Interhand Tissue Dielectric Constant Ratios.
    Lymphat Res Biol 2018 Jun 4. Epub 2018 Jun 4.
    College of Medical Sciences, Department of Physiology, Nova Southeastern University , Ft. Lauderdale, Florida.
    Background: Early detection and tracking of breast cancer treatment-related lymphedema have been helped by quantitative assessment methods and parameters, including bioelectrical impedance spectroscopy and tissue dielectric constant (TDC). Such measurements are evaluated with respect to interarm differences or ratios that (when exceeding specified thresholds) are suggestive of lymphedema. Specific threshold ratios depend on the assessment method and have been reported for arms. Read More

    Evaluation of Pressure-Applying Accuracy in Multilayer Bandaging Among Physiotherapists who Treat Lymphedema.
    Lymphat Res Biol 2018 Jun 4. Epub 2018 Jun 4.
    2 Physical Therapy Department, University of Haifa , Haifa, Israel .
    Background: Compression therapy is the only conservative treatment that has been shown to be effective for patients with lymphedema in randomized controlled trials. A commonly used classification system divides pressure into four categories ranging from mild to very strong. For lower limb edema, bandages with strong pressure were shown to be most effective. Read More

    Giant Penile Lymphedema Caused by Chronic Penile Strangulation with Rubber Band: A Case Report and Review of the Literature.
    Case Rep Urol 2018 14;2018:8598195. Epub 2018 May 14.
    Department of Urology, Faculty of Medicine, Toho University, Tokyo 143-8540, Japan.
    We treated a 65-year-old Japanese man with a giant penile lymphedema due to chronic penile strangulation with a rubber band. He was referred to our hospital with progressive penile swelling that had developed over a period of 2 years from chronic use of a rubber band placed around the penile base for prevention of urinary incontinence. Under a diagnosis of giant penile lymphedema, we performed resection of abnormal penile skin weighing 4. Read More

    Mobilization of Fluids in the Intensive Treatment of Primary and Secondary Lymphedemas.
    ScientificWorldJournal 2018 10;2018:6537253. Epub 2018 May 10.
    Medicine School in São José do Rio Preto (FAMERP) and Researcher Group of the Clínica Godoy, São Jose do Rio Preto, SP, Brazil.
    Background: Lymphedema is a clinical condition resulting from the accumulation of macromolecules in the interstitial space with a consequent buildup of fluids.

    Aim: The objective of this study was to compare the therapeutic response to treatment that mobilizes fluids between primary and secondary lymphedemas.

    Method: Thirty-three patients with severe leg lymphedema who underwent intensive treatment for five consecutive days in 2013 and 2014 at the Clínica Godoy were evaluated in a prospective clinical trial. Read More

    Air Travel Safety in Postoperative Breast Cancer Patients: A Systematic Review.
    Clin Breast Cancer 2018 May 17. Epub 2018 May 17.
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong SAR. Electronic address:
    Air travel has long been a dilemma in post-breast cancer surgery patients. Anecdotal reports have described adverse outcomes on surgical wound, implants, and lymphedema during air travel. This review aims to evaluate the best evidence from the literature concerning the air travel safety in breast cancer patients. Read More

    Neuromuscular taping reduces blood pressure in systemic arterial hypertension.
    Med Hypotheses 2018 Jul 17;116:30-32. Epub 2018 Apr 17.
    Department of Medicine, Imperial College London, UK. Electronic address:
    Systemic arterial hypertension, a well-known cause of morbidity, is associated with dysfunction of the autonomic nervous system. Neuromuscular taping (also known as kinesio taping, medical taping and Vendje neuromuscular) allows movement and muscle activity to treat pain, muscle disorders and lymphoedema, in which its mode of action may involve muscular stimulation leading to increased local blood circulation or stimulating dermatological, muscular and fascial structures with a form of passive massage. We hypothesised that neuromuscular taping may reduce blood pressure in systemic arterial hypertension. Read More

    Metastatic Angiosarcoma of Lower Extremity.
    Indian Dermatol Online J 2018 May-Jun;9(3):177-181
    Department of Dermatology, Topiwala National Medical College and B.Y.L. Nair Hospital, Mumbai, Maharashtra, India.
    Angiosarcoma (AS) is an uncommon malignant neoplasm characterized by rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels. These are aggressive tumors and tend to recur locally, spread widely with high rate of lymph node and systemic metastases. They are more frequent in skin and soft tissue, head and neck being the most common sites. Read More

    Low level laser therapy for the management of breast cancer-related lymphedema: A randomized controlled feasibility study.
    Lasers Surg Med 2018 May 30. Epub 2018 May 30.
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
    Objectives: This study aimed to determine the feasibility of conducting a full scale randomized controlled trial investigating the effectiveness of low level laser therapy (LLLT), also known as photobiomodulation (PBM) therapy, used in addition to conventional therapy, for managing breast cancer related lymphedema (BCRL).

    Materials And Methods: Patients with BCRL were recruited from the Southern District Health Board (New Zealand) via lymphedema therapists' referrals, and randomly allocated into either the laser group, which received BCRL conventional therapy (e.g. Read More

    Massive Localized Lymphedema: Analysis of Intraoperative Care.
    Ann Plast Surg 2018 Jul;81(1):75-79
    From the Division of Plastic Surgery, University of Kentucky, Lexington, KY.
    Massive localized lymphedema (MLL) is rare, but as the prevalence of obesity in adults rises, it can be foreseen that cases will increase in prevalence. These patients are unable to ambulate and have uncontrollable rash and skin breakdown. Operative management for MLL is offered when nonsurgical measures are ineffective. Read More

    First Successful Experimental Implantation of a Drainage Device to Reduce Lymphoedema in a Rat Lymphoedema Model.
    Eur J Vasc Endovasc Surg 2018 May 24. Epub 2018 May 24.
    Angiology Division/Lausanne University Hospital (CHUV), Chemin de Mont Paisible 18, Lausanne, CH 1011, Switzerland. Electronic address:
    Objective/background: Despite recent advances in pharmacological research and microsurgery, lymphoedema remains an incurable disease that deeply affects quality of life. There is an urgent need for innovative approaches to restore continuous lymph flow in affected tissues. To this end, the efficacy of a subcutaneously implanted draining device in reducing lymphoedema volume in a rat hindlimb lymphoedema model was tested. Read More

    Probing the effect of morphology on lymphatic valve dynamic function.
    Biomech Model Mechanobiol 2018 May 26. Epub 2018 May 26.
    George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
    The lymphatic system is vital to the circulatory and immune systems, performing a range of important functions such as transport of interstitial fluid, fatty acid, and immune cells. Lymphatic vessels are composed of contractile walls and lymphatic valves, allowing them to pump lymph against adverse pressure gradients and to prevent backflow. Despite the importance of the lymphatic system, the contribution of mechanical and geometric changes of lymphatic valves and vessels in pathologies of lymphatic dysfunction, such as lymphedema, is not well understood. Read More

    Complex Therapy Physical alone or Associated with Strengthening Exercises in Patients with Lymphedema after Breast Cancer Treatment: a Controlled Clinical Trial
    Asian Pac J Cancer Prev 2018 May 26;19(5):1405-1410. Epub 2018 May 26.
    Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil. Email:
    Objective: To compare a complex physical therapy (CPT) protocol alone or combined with complex physical therapy muscle more strength training (CPT+ST) in patients with lymphedema after breast cancer treatment regarding strength and limb muscle volume. Methods: In this controlled clinical trial, consecutive patients treated from breast cancer from April 2014 to December 2015 were allocated in two groups, the CPT group 1 and the CPT+ST group 2, that performed CPT associated with muscle strengthening. Patients in the CPT group 1 received the routine protocol of care, consisting of manual lymphatic drainage (MLD), multilayer bandage compression therapy, skin care and regular exercises. Read More

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