Search Our Scientific Publications & Authors

J Paediatr Child Health 2020 May 28. Epub 2020 May 28.

Department of Paediatrics, University of Otago, Christchurch, New Zealand.

Primary intestinal lymphangiectasia is an uncommon condition that usually presents early in childhood. This incurable condition is consequent to underlying lymphatic abnormalities that lead to loss of lymphatic contents into the intestinal lumen. This article outlines an approach to the assessment of children presenting with characteristic features and consideration of other conditions that could lead to enteric protein loss. Read More

Antioxidants (Basel) 2020 May 5;9(5). Epub 2020 May 5.

Pharma Nord (DK) ApS, Sadelmagervej 30-32, DK-7100 Vejle, Denmark.

A lack of understanding of the processes determining the absorption and subsequent metabolism of coenzyme Q (CoQ) has resulted in some manufacturers' making incorrect claims regarding the bioavailability of their CoQ supplements, with potential consequences for the use of such products in clinical trials. The purpose of the present review article is, therefore, to describe the various stages of exogenous CoQ metabolism, from its first ingestion, stomach transit, absorption from the small intestine into the lymphatic system, transport in blood, and access into cells. In particular, the importance of CoQ crystal dispersion in the initial formulation is emphasised, the absence of which reduces bioavailability by 75%. Read More

Radiologe 2020 May;60(5):445-458

Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland.

Backround: Malignant lymphomas represent approximately 5% of all cancers. Imaging procedures play a crucial role concerning initial staging and assessment of the response to treatment.

Objective: This article gives an overview of the significance of imaging procedures in the treatment of patients with malignant lymphomas at various times during treatment. Read More

Glycobiology 2020 Feb 10. Epub 2020 Feb 10.

Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland.

Vascular endothelia are covered with a dense glycocalix that is heavily sialylated. Sialylation of vascular glycoconjugates is involved in the regulation of cell-cell interactions, be it among endothelial cells at cell junctions or between endothelial and blood-borne cells. It also plays important roles in modulating the binding of soluble ligands and the signalling by vascular receptors. Read More

Cancers (Basel) 2020 Jan 17;12(1). Epub 2020 Jan 17.

Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.

Ionising radiation (IR) is commonly used for cancer therapy; however, its potential influence on the metastatic ability of surviving cancer cells exposed directly or indirectly to IR remains controversial. Metastasis is a multistep process by which the cancer cells dissociate from the initial site, invade, travel through the blood stream or lymphatic system, and colonise distant sites. This complex process has been reported to require cancer cells to undergo epithelial-mesenchymal transition (EMT) by which the cancer cells convert from an adhesive, epithelial to motile, mesenchymal form and is also associated with changes in glycosylation of cell surface proteins, which may be functionally involved in metastasis. Read More

PLoS Biol 2019 12 19;17(12):e3000486. Epub 2019 Dec 19.

Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.

The conduit network is a hallmark of lymph node microanatomy, but lack of suitable imaging technology has prevented comprehensive investigation of its topology. We employed an extended-volume imaging system to capture the conduit network of an entire murine lymph node (comprising over 280,000 segments). The extensive 3D images provide a comprehensive overview of the regions supplied by conduits, including perivascular sleeves and distinctive "follicular reservoirs" within B cell follicles, surrounding follicular dendritic cells. Read More

Prostate 2020 02 20;80(2):153-161. Epub 2019 Nov 20.

Department of Neurosciences, Institute of Human Anatomy, University of Padova, Padova, Italy.

Background: The evidence of pelvic lymph node metastases after radical prostatectomy (RP) with pelvic lymph node dissection (PLND) is one of the strongest prognostic factors for poor oncologic outcome. The extent of PLND, although representing a crucial step in RP, is still controversial. Currently, there is a critical drawback in clinical practice due to the lack of congruence between the known lymphatic drainage and cancer dissemination despite defined management by a surgical approach. Read More

J Bodyw Mov Ther 2019 Oct 22;23(4):825-834. Epub 2019 May 22.

Barral Osteopathic Teaching Organization, France. Electronic address:

Introduction: Male Chronic Pelvic Pain Syndrome (MCPPS) is a complex condition and difficult to decipher due to the multifactorial etiologies and system interrelationships. No studies to date have described a movement-based, multisystem assessment including the musculoskeletal, visceral, nervous, lymphatic and vascular systems, as well as manual prostate mobility testing. The purpose of this paper is to demonstrate the importance of a comprehensive physical therapy evaluation to identify predominant mechanical and movement-based dysfunctions related to multiple anatomical structures and their interrelationships. Read More

Curr Neuropharmacol 2019 Nov 12. Epub 2019 Nov 12.

Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow Region, 142432, Russian Federation.

Until recently, it was thought that there were no lymphatic vessels in the central nervous system (CNS). Therefore, all metabolic processes were assumed to take place only in the circulation of the cerebrospinal fluid (CSF) and through the blood-brain barrier's (BBB), which regulate ion transport and ensure the functioning of the CNS. However, recent findings yield a new perspective: There is an exchange of CSF with interstitial fluid (ISF), which is drained to the paravenous space and reaches lymphatic nodes at the end. Read More

Chin Clin Oncol 2019 Oct;8(S1):S11

Department of Surgery, Duke University Medical Center, Durham, NC, USA; Duke Cancer Institute, Durham, NC, USA.

Br J Oral Maxillofac Surg 2019 11 12;57(9):847-856. Epub 2019 Oct 12.

Department of Oral and Maxillofacial Surgery, Royal Surrey County Hospital, Egerton Road, Guildford, Surrey, GU2 7XX, UK.

This is the third of three articles that give an overview of the current evidence for management of the neck and parotid in patients with cutaneous cancers of the head and neck. In this paper we discuss Merkel cell carcinoma (MCC) and review the latest evidence for management of the regional nodes. Read More

Clin Anat 2020 Jan 14;33(1):99-107. Epub 2019 Oct 14.

Laboratoire d'Anatomie Des Alpes Françaises, Grenoble Alpes University, Place du commandant Nal, Domaine de La Merci, 38700, La Tronche, France.

The objective of this study was to identify and analyze the anatomical variations in the termination of the thoracic duct (TD) in cadavers or patients by anatomical dissections and surgical or radiological procedures for better knowledge of the interindividual variations through a systematic review. The search strategy included PubMed and reference tracking. Studies were identified by searching the electronic Medline databases. Read More

Front Neurosci 2019 3;13:916. Epub 2019 Sep 3.

Department of Anatomy, Keio University School of Medicine, Tokyo, Japan.

The central nervous system (CNS) and the immune system are both intricate and highly organized systems that regulate the entire body, with both sharing certain common features in developmental mechanisms and operational modes. It is known that innate immunity-related molecules, such as cytokines, toll-like receptors, the complement family, and acquired immunity-related molecules, such as the major histocompatibility complex and antibody receptors, are also expressed in the brain and play important roles in brain development. Moreover, although the brain has previously been regarded as an immune-privileged site, it is known to contain lymphatic vessels. Read More

Adv Drug Deliv Rev 2019 04 25;144:16-34. Epub 2019 Aug 25.

Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University/OHSU, Portland, OR, USA; OHSU Knight Cancer Institute at Oregon Health & Science University, Portland, OR, USA; Department of Biomedical Engineering, School of Medicine at Oregon Health & Science University, Portland, OR, USA. Electronic address:

Although many solid tumors use the lymphatic system to metastasize, there are few treatment options that directly target cancer present in the lymphatic system, and those that do are highly invasive, uncomfortable, and/or have limitations. In this review we provide a brief overview of lymphatic function and anatomy, discusses changes that befall the lymphatics in cancer and the mechanisms by which these changes occur, and highlight limitations of lymphatic drug delivery. We then go on to summarize relevant techniques and new research for targeting cancer populations in the lymphatics and enhancing drug delivery intralymphatically, including intralymphatic injections, isolated limb perfusion, passive nano drug delivery systems, and actively targeted nanomedicine. Read More

Cancer Radiother 2019 Oct 22;23(6-7):696-700. Epub 2019 Aug 22.

Département de radiothérapie, institut universitaire du cancer de Toulouse - Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse, France. Electronic address:

The selection of target volumes for head and neck cancer radiation therapy, particularly prophylactic volumes that reflect infra-clinic spreads, is a complex process. It is based on the knowledge of the natural history of these tumors and must take into consideration the special challenges due to the diversity and complexity of head and neck anatomy. The dosimetric and ballistic precision provided by modern radiation techniques has required strong strategic deliberation to ensure the relevance and reproducibility of target volumes. Read More

Curr Oncol Rep 2019 08 15;21(10):86. Epub 2019 Aug 15.

Susan F. Smith Center for Women's Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.

Purpose Of Review: Inflammatory breast cancer (IBC) is an uncommon but highly aggressive subtype of breast cancer that contributes significantly to breast cancer-related mortality. In this review, we provide an overview of the clinical and molecular characteristics of IBC, and highlight some areas of need for ongoing research.

Recent Findings: The disease is characterized by florid tumor emboli that obstruct dermal lymphatics, leading to swelling and inflammation of the affected breast. Read More

Stroke 2019 09 26;50(9):2539-2546. Epub 2019 Jul 26.

From the Burke Neurological Institute, White Plains, NY (J.Y., E.K., C.B., S.C.).

Background and Purpose- Stroke-induced acute severe body weight (BW) loss is associated with a high rate of mortality during a critical poststroke period. Several interventions to reduce weight loss, however, have not been successful. Currently, the biological significance of this extraordinary catabolic process is not well understood. Read More

Parasite Immunol 2019 10 21;41(10):e12664. Epub 2019 Aug 21.

Laboratory for Biomedical Research, Ghent University Global Campus, Incheon, South Korea.

Trypanosomosis is a chronic parasitic infection, affecting both humans and livestock. A common hallmark of experimental murine infections is the occurrence of inflammation and the associated remodelling of the spleen compartment. The latter involves the depletion of several lymphocyte populations, the induction of T-cell-mediated immune suppression, and the activation of monocyte/macrophage cell populations. Read More

World Neurosurg 2019 Oct 11;130:e941-e952. Epub 2019 Jul 11.

Department of Neurosurgery, The Permanente Medical Group, Kaiser Sacramento Medical Center, Sacramento, California, USA.

Background: Poorly understood cranial fluid accumulations are frequently observed after decompressive craniectomy and often termed "external hydrocephalus." These findings are difficult to explain using traditional models of hydrocephalus.

Methods: Representative cases, clinical management, and literature overview are presented. Read More

Ceska Gynekol 2019 ;84(1):4-17

Objective: To present an overview of minimally invasive approaches to suprapelvic lymphadenectomy and compare two different methods of staging robotic transperitoneal paraaortic lymphadenectomies in patients with early stages of endometrial cancer.

Design: Retrospective study and literature review.

Setting: Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc. Read More

Expert Rev Hematol 2019 07 14;12(7):563-573. Epub 2019 Jun 14.

a Université de Paris, Biologie Intégrée du Globule Rouge, UMR_S1134, BIGR, INSERM, F-75015 , Paris , France.

: In human physiology, the spleen is generally neglected, and its role is considered anecdotal. In sickle cell disease, splenic dysfunction is the main cause of life-threatening complications, particularly in early childhood with the risk of pneumococcal overwhelming sepsis and acute splenic sequestration crisis, notably. During the course of the disease, the spleen functionally declines and anatomically disappears, albeit with great individual variability depending on modulating genetic and environmental factors. Read More

Surg Pathol Clin 2019 Jun;12(2):329-342

Department of Pathology, Anatomic Pathology Division, University of California San Diego Health, 9300 Campus Point Drive, Suite 1-200, MC 7723, La Jolla, CA 92037, USA.

This article gives an overview of the pathologic assessment of resection specimens removed for uterine carcinoma. Areas of controversy and recent developments in pathologic staging are addressed. This includes assessment of myometrial invasion in the setting of adenomyosis, fallopian tube involvement, and vascular invasion. Read More

Arterioscler Thromb Vasc Biol 2019 07 16;39(7):1379-1389. Epub 2019 May 16.

From the Division of Cardiovascular Medicine (J.B.-C., A.F., T.B., L.M., D.T., M.N., J.H., M.B., J.L., Z.M., A.P.S.), Department of Medicine, University of Cambridge, United Kingdom.

Objective- Investigate the impact of modulating B cell FcγRIIb (Fcγ receptor IIb) expression on atherosclerosis. Approach and Results- Western diet-induced atherosclerosis was assessed in Ldlr or Apoe mice with B cell-specific overexpression of FcγRIIb or with an FcγRIIb promoter mutation that alters FcγRIIb expression in germinal center (GC) B cells. In males, overexpression of FcγRIIb on B cells severely reduced activated, class switched B cell responses, as indicated by reductions in GC B cells, plasma cells, and serum IgG but not IgM antibodies. Read More

Chirurg 2019 May;90(5):423-438

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstraße 1, 55131, Mainz, Deutschland.

Lymphadenectomy is an integral component of the oncological surgery of cancer of the gastrointestinal tract and the hepato-pancreato-biliary system. The lymph node dissection is mainly prognostic but may also offer therapeutic advantages in the treatment of most cancers. Moreover, lymphadenectomy enables an accurate TNM staging, which is essential for a further stratification of the individual treatment as well as the inclusion in clinical trials on adjuvant therapy. Read More

J Clin Med 2019 Apr 11;8(4). Epub 2019 Apr 11.

Vascular Biology Center, 1460 Laney Walker Blvd., Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

The lymphatic network is well known for its role in the maintenance of tissue fluid homeostasis, absorption of dietary lipids, trafficking of immune cells, and adaptive immunity. Aberrant lymphatic function has been linked to lymphedema and immune disorders for a long time. Discovery of lymphatic cell markers, novel insights into developmental and postnatal lymphangiogenesis, development of genetic mouse models, and the introduction of new imaging techniques have improved our understanding of lymphatic function in both health and disease, especially in the last decade. Read More

Arch Pathol Lab Med 2020 02 8;144(2):245-251. Epub 2019 Apr 8.

From the Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison.

Autoimmune lymphoproliferative syndrome (ALPS) is an inherited nonmalignant lymphoproliferative disorder characterized by heterozygous mutations within the first apoptosis signal receptor (FAS) signaling pathway. Defects in FAS-mediated apoptosis cause an expansion and accumulation of autoreactive CD4 and CD8 (double-negative) T cells, leading to cytopenias, splenomegaly, lymphadenopathy, autoimmune disorders, and a greatly increased lifetime risk of lymphoma. The differential diagnosis of ALPS includes infection, other inherited immunodeficiency disorders, primary and secondary autoimmune syndromes, and lymphoma. Read More

Microcirculation 2019 11 2;26(8):e12547. Epub 2019 May 2.

Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, Ohio.

Immense progress in microscale engineering technologies has significantly expanded the capabilities of in vitro cell culture systems for reconstituting physiological microenvironments that are mediated by biomolecular gradients, fluid transport, and mechanical forces. Here, we examine the innovative approaches based on microfabricated vessels for studying lymphatic biology. To help understand the necessary design requirements for microfluidic models, we first summarize lymphatic vessel structure and function. Read More

Paediatr Respir Rev 2019 Feb 19;29:53-59. Epub 2018 May 19.

Service de Pneumologie Pédiatrique et Centre de référence des maladies respiratoires rares, AP-HP, Hôpital Trousseau, Unité INSERM UMR-S933, Sorbonne Université, Paris, France. Electronic address:

Paediatric sarcoidosis is an extremely rare disease characterized by a granulomatous inflammation. The estimated incidence is 0.6-1. Read More

Magn Reson Imaging Clin N Am 2019 May;27(2):373-385

Division of Thoracic Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

Recent advances in understanding lymphatic disorders have significantly improved noninvasive imaging of the lymphatic circulation, especially in pediatric patients. The ability to obtain high-quality MR imaging using 3-dimensional reconstruction has transformed the display of the lymph vessels and substantially enhanced the ability to diagnose various pediatric lymphatic disorders. Real-time dynamic imaging adds functional information to the assessment. Read More

Semin Immunol 2019 02 21;41:101269. Epub 2019 Mar 21.

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. Electronic address:

Innate lymphocytes play an important role in maintaining tissue homeostasis at steady state and during inflammation. The population of innate lymphocytes is incredibly diverse and heterogeneous with the successive identification of new subsets including innate lymphoid cells that arise from progenitors distinct from those of natural killer cells. Although generally considered as T helper-like lymphocytes, innate lymphoid cells with cytotoxic potential can be identified in many tissues. Read More

Clin Exp Med 2019 May 21;19(2):225-234. Epub 2019 Mar 21.

Pathogens Biology Institute, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, 730000, China.

Several systematic reviews have investigated the accuracy of imaging modalities for lymph node involvement of rectal cancer, but there are considerable differences in conclusions. This overview aimed to assess the methodological and reporting quality of systematic reviews that evaluated the diagnostic value of imaging modalities for lymph node involvement in patients with rectal cancer and to compare the diagnostic value of different modalities for lymph node involvement. The PubMed, EMBASE, Cochrane Library and Chinese Biomedicine Literature were searched to identify relevant systematic reviews. Read More

Immunol Lett 2019 11 4;215:12-18. Epub 2019 Mar 4.

UMR_S 1236, Université Rennes 1, INSERM, Etablissement Français du Sang, F-35000, Rennes, France; SITI, Pôle de Biologie, CHU Pontchaillou, F-35000, Rennes, France. Electronic address:

Stromal cells have been considered for a long time essentially as a structural component organizing tissue architecture, including those of secondary lymphoid organs. More recently, highly specialized stromal cell subsets were shown to differentially organize immune cell recruitment, survival, and differentiation within lymph nodes. In particular, mature B cells interact with different lymphoid stromal cell networks through bidirectional interactions involving cell-cell contact and soluble factors. Read More

Eur Surg Res 2019 22;60(1-2):45-52. Epub 2019 Feb 22.

Department of Surgery, St Richard's Hospital, Chichester, United Kingdom,

Sentinel lymph node mapping (SLNM) may play a significant role in future delivery of colon cancer surgery because of an increase in early-stage, node-negative disease due to national bowel cancer screening programmes. Traditionally, colon lymphatic drainage has not been thought relevant as the operative approach cannot be tailored. Recent advances in local and endoscopic risk-reducing interventions for colonic malignancy have caused a rethink in approach. Read More

Zentralbl Chir 2019 Sep 22;144(S 01):S24-S30. Epub 2019 Feb 22.

Radiologische Klinik, Universitätsklinikum Bonn, Deutschland.

Therapeutic options in management of chylothorax encompass conservative, surgical and also interventional measures. Despite the fact that interventions have been performed in substantial numbers of patients - particularly thoracic duct embolisations - general knowledge about this therapeutic option is still limited. Therefore, this article gives an overview of the state of the art for therapeutic options, also emphasising radiological/interventional procedures. Read More

Pathol Res Pract 2019 May 30;215(5):849-854. Epub 2019 Jan 30.

Department of Surgical Gastroenterology Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 7, 2100, Copenhagen Ø, Denmark.

Background/introduction: Isolated tumor cells (ITC) are tumor cells identified in the regional lymph nodes of patients with adeno- or squamous cell carcinoma of the esophagogastric junction (EGJ) or the esophagus. The current staging guidelines for these cancers do not assign any prognostic relevance to ITC, but their role remains debatable. We evaluated current literature to provide an overview of the prognostic relevance of ITC in regional lymph nodes of patients diagnosed with node negative cancer of the esophagus and EGJ. Read More

Kidney Int 2019 04 31;95(4):774-786. Epub 2019 Jan 31.

Service de Néphrologie et Transplantation, Pôle Cancérologie-Immunité-Transplantation-Infectiologie, Paris-Est Creteil, France; Institut National de la Santé et de la Recherch Médicale, U955, Equipe 21 and Université Paris-Est, Créteil, France. Electronic address:

There is an urgent need for therapeutic agents that target humoral alloimmunity in solid organ transplantation. This includes sensitized patients with preformed donor-specific human leukocyte antigen antibodies and patients who develop de novo donor-specific antibodies, both of which are associated with acute and chronic antibody-mediated rejection and allograft loss. In the last decade, both experimental and clinical studies highlighted the major impact of costimulation molecules in the control of immune responses both in the field of transplantation and autoimmune disease. Read More

J Pathol 2019 04 4;247(5):662-671. Epub 2019 Feb 4.

Centre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Recent advances have provided evidence for the involvement of neutrophils in both innate and adaptive immunity, robustly challenging the old dogma that neutrophils are short-lived prototypical innate immune cells solely involved in acute responses to microbes and exerting collateral tissue damage. There is now ample evidence showing that neutrophils can migrate into different compartments of the lymphoid system where they contribute to the orchestration of the activation and/or suppression of lymphocyte effector functions in homeostasis and during chronic inflammation, such as autoimmune disorders and cancer. In support of this notion, neutrophils can generate a wide range of cytokines and other mediators capable of regulating the survival, proliferation and functions of both T and B cells. Read More

Breast 2019 Apr 17;44:15-23. Epub 2018 Dec 17.

Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy. Electronic address:

Breast cancer related lymphedema (BCRL) develops as a consequence of surgical treatment and/or radiation therapy in a significant number of breast cancer patients. The etiology of this condition is multifactorial and has not yet been completely elucidated. Risk factors include high body mass index, radical surgical procedures (i. Read More

Forensic Sci Med Pathol 2019 03 5;15(1):75-83. Epub 2018 Dec 5.

Department of Biological Sciences, Florida International University, Miami, FL, USA.

Death does not occur instantaneously and organs do not decompose at the same rate or in the same way. Nulligravid human uteri and prostate glands are the last internal organs to deteriorate during decomposition; however, the reason for this very important observation is still enigmatic. Recent studies have elucidated that the composition and abundance of microbes in the human thanatomicrobiome (microbiome of death) varies by organ and changes as a function of time and temperature. Read More

Pediatr Radiol 2019 02 5;49(2):266-276. Epub 2018 Dec 5.

Department of Radiology and Nuclear Medicine, University Medical Center Utrecht/Wilhelmina Children's Hospital, Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands.

Detecting extranodal disease in paediatric Hodgkin lymphoma is of great importance for both treatment and prognosis. Different imaging techniques can be used to identify these extranodal sites. This pictorial essay provides an overview of imaging features of extranodal disease manifestation in paediatric Hodgkin lymphoma. Read More

Ther Umsch 2018 Nov;75(4):209-214

2 Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zürich.

Gaucher's disease - an overview about a sphingolipidosis Abstract. Gaucher's disease is a sphingolipidosis which results from an insufficient production of the enzyme glucocerebrosidase, a lysosomal hydrolase. Glucocerebrosides accumulate particularly in macrophages. Read More

BMC Cancer 2018 Nov 21;18(1):1153. Epub 2018 Nov 21.

Institut Paoli Calmettes & CRCM & Aix Marseille Univ, 232 Bd de Sainte Marguerite, 13009, Marseille, France.

Background: Three randomized trials have concluded at non inferiority of omission of complementary axillary lymph node dissection (cALND) for patients with involved sentinel node (SN). However, we can outline strong limitations of these trials to validate this attitude with a high scientific level. We designed the SERC randomized trial ( ClinicalTrials. Read More

Med Sci (Paris) 2018 Nov 12;34 Hors série n°2:26-31. Epub 2018 Nov 12.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France - Centre National de la Recherche Scientifique (CNRS), UMR7104, Illkirch, France - Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, Illkirch, France - Université de Strasbourg, Illkirch, France.

Calcium (Ca) is an essential regulator for a large number of cellular functions in various tissues and organs, and small disturbances of Ca homeostasis can severely compromise normal physiology. Intracellular Ca balance is mainly controlled by the reticular Ca sensor STIM1 and the plasma membrane Ca channel ORAI1 through a mechanism known as store-operated Ca entry (SOCE). Gain-of-function mutations in STIM1 or ORAI1 cause excessive extracellular Ca influx, resulting in tubular aggregate myopathy (TAM) and Stormorken syndrome (STRMK). Read More

Medicine (Baltimore) 2018 Oct;97(43):e12899

Gansu Provincial Hospital, Lanzhou, China.

Background: Rectal cancer is one of the most common tumors and is the leading cause of cancer-related deaths in developed countries. Lymph node involvement remains the strongest prognostic factor associated with a worse prognosis in patients with rectal cancer. Several systematic reviews have investigated the accuracy of endoscopic ultrasound, computed tomography, magnetic resonance imaging, and endorectal ultrasonography for lymph node involvement of rectal cancer and compared the diagnostic accuracy of different imaging techniques, but there are considerable differences in conclusions. Read More

In Vivo 2018 Nov-Dec;32(6):1301-1307

The London Breast Institute, Princess Grace Hospital, London, U.K.

The sentinel lymph node biopsy (SLNB) has become the new standard-of-care for patients with clinically node-negative invasive breast cancer. The focused examination of fewer lymph nodes in addition to improvements in histopathological and molecular analysis have increased the rate at which micrometastases and isolated tumor cells are identified. We reviewed the literature and summarized the evidence regarding the need for complete axillary lymph node dissection (ALND) following the finding of a positive sentinel node biopsy through the identification of the most important outcomes and evaluation of quality of evidence. Read More

Scand J Gastroenterol 2018 Oct - Nov;53(10-11):1153-1164. Epub 2018 Oct 21.

a Academic Department of Gastroenterology , Laiko General Hospital Medical School University of Athens , Athens , Greece.

Portal hypertension (PH) is a major complication of liver cirrhosis, as it predisposes to the development of serious clinical manifestations such as ascites, hepatic encephalopathy and variceal bleeding. Till now, the measurement of hepatic vein pressure gradient (HVPG) is the gold standard method to ascertain the presence and significance of PH, as many studies have shown its correlation with the appearance of varices and the possibility of variceal bleeding. However, the invasiveness of this procedure makes it difficult to be used in daily clinical practice. Read More

Zentralbl Chir 2019 Jun 15;144(3):290-297. Epub 2018 Oct 15.

Klinik für Thoraxchirurgie, REGIOMED Kliniken GmbH, Sonneberg/Coburg, Deutschland.

Background: Chylothorax is a multifactorial complication, usually caused by surgery or traumatic injury, and more rarely by malignant disease. Because of the lack of prospective, randomised trials, the evidence-based treatment rests upon personal experience, but ideally taking into account retrospective analysis.

Material And Methods: The aim of this review is to provide a comprehensive overview of the currently available modern treatment options. Read More

Gynecol Oncol 2019 01 11;152(1):202-207. Epub 2018 Oct 11.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom.

Sentinel lymph node (SLN) biopsy has been increasingly used in the management of early-stages cervical cancer instead of systematic pelvic lymph node dissection (PLND). The aim of this article is to give a critical overview of key aspects related to this concept, such as a necessity for reliable detection of micrometastases (MIC) in SLN and the requirements for SLN pathologic ultrastaging, low accuracy of intraoperative detection of SLN involvement, and still a limited evidence of oncological safety of the replacement of PLND by SLN biopsy only in ≥IB1 tumours due to unknown risk of MIC in non-SLN pelvic lymph nodes in patients with negative SLN, and absence of any prospective evidence. Read More

J Clin Pathol 2019 Apr 1;72(4):265-270. Epub 2018 Oct 1.

Dermatopathology Section, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Cutaneous melanoma causes most of the skin cancer deaths in the USA. Melanoma is the fifth most common cancer among men and the sixth most common cancer among women. The incidence of melanoma has risen sharply over the past three decades. Read More

Cell Calcium 2018 12 3;76:1-9. Epub 2018 Sep 3.

Departement of Translational Medicine and Neurogenetics, IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, Illkirch, France.

Calcium (Ca) is a key regulator for a large number of cellular functions in all kinds of cells, and small disturbances of Ca homeostasis can severely compromise normal physiology in various tissues and organs. A major mechanism controlling Ca homeostasis is store-operated Ca entry (SOCE), which relies on the concerted action of the reticular Ca sensor STIM1 and the plasma membrane Ca channel ORAI1. Gain-of-function mutations in the respective genes induce excessive Ca entry, and cause tubular aggregate myopathy (TAM) and Stormorken syndrome. Read More