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Intern Med 2018 Sep 18;57(18):2709-2712. Epub 2018 May 18.

Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Japan.

A 36-year old man was referred to our hospital due to isolated chronic cough that was refractory to anti-asthma medications, including inhaled corticosteroids/long-acting β agonists. Chest X-ray showed diffuse nodular and enhanced vascular shadows with Kerley lines in both lungs. A blood analysis showed elevated serum carcinoembryonic antigen (CEA) and CA19-9 levels. Read More

BMC Cancer 2018 03 16;18(1):300. Epub 2018 Mar 16.

Department of Radiology, Japanese Red Cross Kochi Hospital, 2-13-51, Shinhonmachi, Kochi-city, Kochi, 780-8562, Japan.

Background: Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data have not been reported. Read More

Urology 2018 Apr 29;114:e1-e2. Epub 2017 Dec 29.

Department of Nuclear Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

Lymphangitic carcinomatosis refers to the rare process of diffuse malignant invasion of the pulmonary lymphatics. We describe the first reported case of lymphangitic carcinomatosis visualized with gallium-68 prostate-specific membrane antigen positron emission tomography and its clinical significance in a 53-year-old man with prostate carcinoma. This case highlights the ability of gallium-68 prostate-specific membrane antigen positron emission tomography for prostate carcinoma characterization and the importance of always considering atypical patterns of metastatic disease. Read More

Pediatr Radiol 2017 Nov 8;47(12):1615-1621. Epub 2017 Jul 8.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway, Campus Box 8131, St. Louis, MO, 63110, USA.

Background: Renal medullary carcinoma is a rare renal malignancy of childhood. There are no large series describing the imaging appearance of renal medullary carcinoma in children.

Objective: To characterize the clinical and imaging features of pediatric renal medullary carcinoma at initial presentation. Read More

World J Clin Oncol 2017 Jun;8(3):285-288

Virginia W Osborn, Andrea Leaf, Anna Lee, Elizabeth Garay, Joseph Safdieh, David Schwartz, David Schreiber, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY 11209, United States.

We are reporting a case of fatal radiation pneumonitis that developed six months following chemoradiation for limited stage small cell lung cancer. The patient was a 67-year-old man with a past medical history of Hashimoto's thyroiditis and remote suspicion for CREST, neither of which were active in the years leading up to treatment. He received 6600 cGy delivered in 200 cGy daily fractions intensity modulated radiation therapy with concurrent cisplatin/etoposide followed by additional chemotherapy with dose-reduced cisplatin/etoposide and carboplatin/etoposide and then received prophylactic cranial irradiation. Read More

Medicine (Baltimore) 2016 Nov;95(47):e5426

aDepartment of Radiology, CHA Bundang Medical Center, CHA University, Yatap-dong, Bundang-gu, Seongnam-si, Gyeonggi-do bDepartment of Radiology, St. Mary Dain Hospital, Mangpo-dong, Youngtong-gu, Suwon-si cDepartment of Radiology, Seoul National University Hospital, Daehak-ro, Jongno-gu, Seoul, Republic of Korea.

The purpose of this study was to clarify the recognizable computed tomography (CT) features of small cell lung carcinoma (SCLC).Contrast enhanced CT scans were reviewed retrospectively for mass location, mediastinal extension, and other concomitant findings in 142 patients with pathologically proven SCLC. SCLC was classified into hilar mass only (type I), hilar mass with ipsilateral mediastinal extension (type II), hilar mass with bilateral mediastinal extension (type III), and peripheral mass (type IV). Read More

BJR Case Rep 2016 2;2(4):20150171. Epub 2016 Nov 2.

Southampton University Hospital NHS Trust, Southampton, UK.

This report highlights the diagnostic complexities involved in the case of a 63-year-old female who presented with a non-productive cough and shortness of breath on exertion. Initial chest radiograph demonstrated generalized abnormal interstitial lung markings with thickened peripheral septal lines. Further characterization was sought by CT scan of the chest, and given the possibility of lymphangitic carcinomatosis, a CT scan of the abdomen and pelvis was also performed. Read More

Anticancer Res 2016 Aug;36(8):4313-20

Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan, R.O.C.

Aim: To assess the correlation between advanced non-small cell lung cancer (NSCLC) with or without pulmonary lymphangitic carcinomatosis (PLC) and fluorodeoxyglucose (FDG) uptake and its effect on survival outcomes.

Patients And Methods: We retrospectively reviewed 157 patients with NSCLC. The mean and maximum standardized uptake values (SUVmean and SUVmax, respectively), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were evaluated for their effect on overall survival (OS) and progression-free survival (PFS). Read More

Medicine (Baltimore) 2016 Feb;95(6):e2795

From the Department of Radiation Oncology (DSL, YSK, CSK, SHK); Division of Pulmonology (CDY, JWK, SJK, YKK), Department of Internal Medicine; Division of Medical Oncology (YHK, JHK), Department of Internal Medicine; Department of Hospital Pathology (KYL); and The Cancer Research Institute (SJK), College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, South Korea.

This study was designed to compare the primary patterns of metastases and clinical outcomes between adenocarcinoma (Adenoca) and squamous cell carcinoma (SQ) in initially diagnosed stage IV non-small cell lung cancer (NSCLC).Between June 2007 and June 2013, a total of 427 eligible patients were analyzed. These patients were histologically confirmed as Adenoca or SQ and underwent systemic imaging studies, including 18F-fluorodeoxyglucose positron emission tomography/computed tomography and brain imaging. Read More

Abdom Radiol (NY) 2016 Feb;41(2):295-302

Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.

Purpose: To compare the metastatic pattern and outcome of clear cell RCC (ccRCC) and papillary RCC (pRCC), and to assess the impact of sarcomatoid transformation on the disease spread and prognosis.

Materials And Methods: This IRB-approved, HIPAA-compliant retrospective study included 149 consecutive patients (108 men; mean age 58 years; range 25-86) with metastatic RCC (ccRCC = 116, pRCC = 33), identified from imaging database. All available imaging studies and electronic records of these patients were reviewed to document pathological features, distribution and timing of metastasis, and survival. Read More

BMJ Case Rep 2015 Jul 22;2015. Epub 2015 Jul 22.

Division of Immunology, University of Iowa, Iowa City, Iowa, USA.

An elderly woman with a history of pulmonary tuberculosis reportedly diagnosed and treated 30 years prior to presentation was found unresponsive at home. Chest imaging revealed innumerable pulmonary nodules worrisome for an infectious process, specifically tuberculosis. The patient deteriorated rapidly and in accordance with her wishes, aggressive interventions were withheld. Read More

World J Gastroenterol 2015 Feb;21(7):2206-9

Tricia Murdock, Maryam Zenali, Department of Pathology, University of Vermont-College of Medicine/Fletcher Allen Health Care, Burlington, VT 05401, United States.

Due to the anatomical peculiarity of the appendix, diagnosis of tumors arising from this area can be challenging by clinicoradiologic means. We report a case of a rare primary appendiceal signet ring carcinoma with an uncommon presentation. An 86-year-old woman was admitted to our hospital with subacute epigastric pain. Read More

Abdom Imaging 2015 Aug;40(6):1997-2011

Department of Radiology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva, Switzerland,

The liver normally produces a large amount of lymph. It is estimated that between 25% and 50% of the lymph received by the thoracic duct comes from the liver. In normal conditions, hepatic lymphatics are not depicted on cross-sectional imaging. Read More

Radiology 2015 Apr 7;275(1):272-9. Epub 2015 Jan 7.

From the Departments of Pulmonary and Critical Care Medicine (C.M.C., W.S.K.), Oncology (C.M.C.), Radiology and Research Institute of Radiology (M.Y.K.), and Clinical Epidemiology and Biostatistics (J.B.L.), University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul 138-736, Korea; and Department of Radiology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Seoul, Korea (H.J.H.).

Purpose: To study the differences in computed tomographic (CT) characteristics between patients with advanced lung adenocarcinoma who have anaplastic lymphoma kinase (ALK) gene rearrangement and those who have epidermal growth factor receptor (EGFR) mutations.

Materials And Methods: This retrospective study was approved by the institutional review board. Informed consent was waived. Read More

World J Surg Oncol 2014 Mar 27;12:66. Epub 2014 Mar 27.

Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, 310003 Hangzhou, Zhejiang, China.

Primary liver carcinoma is the most important malignant disease. The nodular metastatic foci of liver carcinoma are usually found in the lung, adrenal gland or abdomen after resection or transplantation. Pulmonary lymphangitic carcinomatosis (PLC) accounts for approximately 6% to 8% of metastatic cancer in the lung. Read More

Int J Oral Maxillofac Surg 2014 Jul 4;43(7):806-10. Epub 2014 Mar 4.

Royal Sussex County Hospital, Brighton, East Sussex, UK.

Pulmonary lymphangitic carcinomatosis (PLC) secondary to mucosal head and neck squamous cell carcinoma (HNSCC) is extremely rare, difficult to diagnose in the pre-symptomatic phase, and is rapidly fatal. We describe two cases of fatal PLC secondary to squamous cell carcinoma in whom a review of pre-treatment imaging (computed tomography of the chest) changes reported as unspecific were retrospectively felt to be consistent with pre-symptomatic PLC. Case 1, a 73-year-old male with T2N2bMx poorly differentiated squamous cell carcinoma of the right tonsil, died 6 weeks after chemoradiotherapy with curative intent. Read More

Hematol Oncol Stem Cell Ther 2013 Sep-Dec;6(3-4):117-9. Epub 2013 Oct 3.

Department of Medicine, 3000 Arlington Ave., Toledo, OH 46314, United States. Electronic address:

Docetaxel belongs to the taxane family of anti-cancer drugs, which are commonly used in non-small cell lung cancers. They stabilize microtubules by preventing depolymerization, resulting in cell death. Pneumonitis is an uncommon side effect of docetaxel. Read More

Insights Imaging 2013 Feb 18;4(1):9-27. Epub 2012 Dec 18.

Department of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece,

Septal, reticular, nodular, reticulonodular, ground-glass, crazy paving, cystic, ground-glass with reticular, cystic with ground-glass, decreased and mosaic attenuation pattern characterise interstitial lung diseases on high-resolution computed tomography (HRCT). Occasionally different entities mimic each other, either because they share identical HRCT findings or because of superimposition of patterns. Idiopathic pulmonary fibrosis (IPF), fibrosis associated with connective tissue disease, asbestosis, end-stage sarcoidosis or chronic hypersensitivity pneumonitis (HP) may present with lower zone, subpleural reticular pattern associated with honeycombing. Read More

BMC Res Notes 2012 Nov 16;5:638. Epub 2012 Nov 16.

Department of Gastroenterology, University Hospitals Leuven, Digestive Oncology Unit, Herestraat 49, 3000 Leuven, Belgium.

Background: Lymphangitic carcinomatosis as a manifestation of gastric carcinoma is rare. The presenting symptoms are misleading and nonspecific, often resulting in delayed diagnosis.

Case Presentation: We present a case of a 24 year old male with progressive dyspnea. Read More

Nucl Med Mol Imaging 2012 Jun 4;46(2):150-1. Epub 2012 Feb 4.

Department of Nuclear Medicine & PET, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Nihon Kokyuki Gakkai Zasshi 2011 Dec;49(12):949-54

Department of Internal Medicine, Nippon Medical School, Musashikosugi Hospital.

We report the case of a 67-year-old man with a diagnosis of stage IV stomach cancer in May 2010 who was treated with outpatient chemotherapy using TS-1, paclitaxel and lentinan. Dyspnea and coughing developed after drug administration in November and the patient was hospitalized on day 5 after the appearance of symptoms due to hypoxemia and the presence of ground-glass opacities in the right middle and lower lung fields. On the same day, bronchoscopy was performed for differentiation from infection and lymphangitic carcinomatosis. Read More

Can Assoc Radiol J 2012 Nov 14;63(4):294-303. Epub 2011 Dec 14.

Diagnostic Imaging Department, Lakeshore General Hospital, Montreal, Quebec, Canada.

Purpose: Findings not associated with thromboembolic disease on routine perfusion lung scan may sometimes have particular clinical significance. We wanted to assess the clinical importance and overall survival after the recognition of a lymphangitic carcinomatosis pattern on perfusion lung scan.

Case Report: We report a case of lymphangitic carcinomatosis pattern on perfusion lung scan performed in a previously healthy patient who had rapid progressive course and died the next day. Read More

Radiographics 2011 May-Jun;31(3):771-89

Department of Bioimaging and Radiological Sciences, Catholic University, A. Gemelli Hospital, Largo A. Gemelli 8, 00168 Rome, Italy.

Three-dimensional (3D) conformal radiation therapy (CRT) and stereotactic body radiation therapy (SBRT) are designed to deliver the maximum therapeutic radiation dose to the tumor, allowing improved local disease control, while minimizing irradiation of surrounding normal structures. The complex configuration of the multiple beams that deliver the radiation dose to the tumor in 3D CRT and SBRT produces patterns of lung injury that differ in location and extent from those seen after conventional radiation therapy. Radiation-induced changes in lung tissue after 3D CRT and SBRT occur within the radiation portals. Read More

J Ark Med Soc 2010 Dec;107(7):132-4

Pulmonary lymphangitic carcinomatosis (PLC) refers to the infiltration of lung lymphatic channels with metastatic carcinoma and is associated with a dismal prognosis. PLC accompanies circa 7% of all pulmonary metastases and is most commonly caused by various metastatic adenocarcinomas. Only two cases of PLC due to squamous cell lung carcinoma have been reported to date in the English literature. Read More

World J Surg Oncol 2010 Dec 3;8:107. Epub 2010 Dec 3.

Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

Introduction: Pulmonary metastasis presenting as lymphangitic carcinomatosis arising from squamous cell carcinoma (SCC) of the cervix is a rare event. Poorly represented in the literature, this event is associated with a) difficulty in accurate diagnosis, b) grave prognosis, and the c) lack of recognized predisposing risk factors.

Case Report: A 50 year-old female presented at our practice with a three-month history of a productive cough associated with dyspnoea and shortness of breath. Read More

AJR Am J Roentgenol 2010 Jan;194(1):231-6

Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St., 202 Founders, Boston MA 02114, USA.

Objective: The purpose of this study was to assess the role of PET/CT in the diagnosis of pulmonary lymphangitic carcinomatosis.

Materials And Methods: Integrated PET/CT images of 35 patients (15 men, 20 women; mean age, 64.5 years) with pulmonary lymphangitic carcinomatosis confirmed at follow-up chest CT or histopathologic examination were analyzed retrospectively. Read More

Nihon Kokyuki Gakkai Zasshi 2009 Aug;47(8):687-91

Department of Hematology and Respiratory Medicine, Kochi University

A 70-year-old woman with breast cancer treated with hormonal therapy had progressive shortness of breath for one month. Chest radiograph and computed tomography showed mild interstitial changes, but could not account for her respiratory failure. Lymphangitic carcinomatosis, drug-induced pneumonitis, idiopathic interstitial pneumonitis, opportunistic infection, and pulmonary edema were considered in the differential diagnosis of the CT findings. Read More

Am J Med Sci 2009 Apr;337(4):302-4

Divisions of pulmonology, St. Paul's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Erdheim-Chester disease (ECD) is a rare proliferative non-Langerhans cell histiocytosis of multiple organs with unknown etiology. Around 20% of ECD cases are reported to be associated with lung involvement and there are very few cases manifested solely by nonspecific respiratory symptoms. A 50-year-old woman presented with dry cough and dyspnea for 2 weeks. Read More

CMAJ 2008 Aug;179(4):338-40

Department of Medicine, State University of New York, Syracuse, New York, USA.

Pulmonary lymphangitic carcinomatosis is a metastatic lung disease characterized by diffuse spread of the tumour to the pulmonary lymphatic system. We describe the case of a 31-year-old woman who initially received a diagnosis of sarcoidosis based on the results of imaging studies. However, results of a transbronchial biopsy led to the diagnosis of pulmonary lymphangitic carcinomatosis from metastatic colon cancer. Read More

Radiographics 2008 May-Jun;28(3):883-99; quiz 915

Department of Radiologic Pathology, Armed Forces Institute of Pathology, 14th St and Alaska Ave NW, Washington, DC 20306, USA.

Pulmonary alveolar proteinosis (PAP) may develop in a primary (idiopathic) form, chiefly during middle age, or less commonly in the setting of inhalational exposure, hematologic malignancy, or immunodeficiency. Current research supports the theory that PAP is the result of pathophysiologic mechanisms that impair pulmonary surfactant homeostasis and lung immune function. Clinical symptomatology is variable, ranging from mild progressive dyspnea to respiratory failure. Read More

Pediatr Radiol 2008 May 2;38(5):551-8. Epub 2008 Feb 2.

Department of Radiology, All India Institute of Medical Sciences, New Delhi, India 110029.

Pulmonary metastases are common in osteosarcoma and the most common appearance is of multiple well-defined nodules in the lung parenchyma. However, a variety of atypical locations and presentations of osteosarcoma metastasis can occur in the thorax. We present a review of the thoracic CT findings in 16 patients with histopathologically confirmed osteosarcoma with unusual thoracic manifestations. Read More

An Med Interna 2007 Jun;24(6):289-91

Servicio de Medicina Interna, Hospital Nuestra Señora del Prado, Talavera de la Reina, Toledo.

A case of a 30-year-old man is presented. He had a past medical history of asthma and presented with cough, shortness of breath, fever and chest pain. The chest X-ray showed cardiomegaly and a interstitial pattern. Read More

Intern Med 2007 17;46(8):491-4. Epub 2007 Apr 17.

Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba.

A 37-year-old man was referred to our hospital with complaints of dyspnea and general fatigue. Chest radiograph and CT scan revealed thickness of bronchovascular bundles in both lungs. In spite of various examinations, the primary lesion was not identified. Read More

Clin Nucl Med 2006 Nov;31(11):673-8

Division of Nuclear Medicine, Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA.

The lungs are among the most common sites for metastases from a multitude of cancers. The majority of pulmonary metastases appear nodular on radiologic images. Interstitial spread of tumor through pulmonary lymphatics, also known as pulmonary lymphangitic carcinomatosis (PLC), is not uncommon and constitutes approximately 7% of pulmonary metastases. Read More

Ai Zheng 2006 Sep;25(9):1127-30

Department of Internal Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.

Background & Objective: Pulmonary lymphangitic carcinomatosis (PLC) is a special type of pulmonary metastasis of carcinoma. It is easy to be misdiagnosed as other pulmonary interstitial diseases. This study was to discuss the clinical features of PLC, and provide experience information for diagnosis, differentiated diagnosis, and evaluation of prognosis of PLC. Read More

J Comput Assist Tomogr 2006 Jul-Aug;30(4):653-61

Department of Radiology, Kyoto University Hospital, Shogoin Kawaharamachi 54 Sakyo, Kyoto-City, Kyoto Prefecture Japan.

Objective: The aim of this study was to classify the types of tumor extension and spread of small cell lung carcinoma (SCLC) and to recognize the unusual types of spread pattern of SCLC on computed tomography (CT) including multidetector row CT (MDCT) using contrast-enhanced material.

Materials And Methods: Sixty-eight cases (53 men and 15 women aged 54-83 years old) of pathologically proven SCLC were examined mainly by contrast-enhanced CT scan. In surgically treated 7 cases, CT-pathologic correlations were performed. Read More

Lung Cancer 2006 Sep 5;53(3):387-90. Epub 2006 Jul 5.

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

We report the case of a woman with gefitinib-sensitive lung adenocarcinoma, who was successfully re-treated with gefitinib for carcinomatous meningitis as the disease recurrence. The good response to gefitinib treatment was supported in part by the existence of epidermal growth factor receptor mutation in carcinoma cells in the specimen obtained from transbronchial lung biopsy, in which E709G in exon 18 and L858R in exon 21 were shown. Although carcinomatous meningitis had been well controlled by the treatment with gefitinib, serum carcinoembryonic antigen (CEA) level increased with re-growth of primary tumor and development of lymphangitic carcinomatosis. Read More

Respir Care 2006 May;51(5):515-8

Internal Medicine Service, William Beaumont Army Medical Center, El Paso, TX 79920, USA.

We present a case of organizing pneumonia associated with lymphangitic spread of ovarian carcinoma in a 60-year-old Hispanic female with progressive dyspnea, hypoxemia, and bilateral pulmonary infiltrates. The patient was treated with corticosteroids, and she had rapid clinical and radiographic improvement. Malignancy-associated organizing pneumonia has most often been reported in bone-marrow transplant and breast-cancer patients receiving radiation therapy. Read More

J Comput Assist Tomogr 2005 Sep-Oct;29(5):588-91

Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara-cho, Okinawa, Japan.

Objective: The objective of this study was to evaluate whether maximum intensity projection (MIP) images increased the ability of experienced and resident radiologists to differentiate between the micronodular distribution of focal and diffuse infiltrative lung diseases.

Methods: The cases used in the study were those of 26 patients with focal or diffuse micronodular lung diseases, including 7 cases of sarcoidosis, 6 of miliary tuberculosis, 3 of pulmonary tuberculosis, 3 of chronic bronchitis, 2 of human T-lymphotropic virus type 1-associated bronchoalveolar disorder, 2 of diffuse aspiration bronchiolitis, 1 of atypical mycobacterial infection, and 1 of lymphangitic carcinomatosis. Scans of the entire lung during a single breath hold at 1. Read More

Ann Univ Mariae Curie Sklodowska Med 2004 ;59(1):1-5

2nd Department of Radiology, Skubiszewski Medical University of Lublin.

High resolution computed tomography is a diagnostic method of choice in the evaluation of lung parenchyma. HRCT enables the evaluation of small interstitial changes, invisible on plain chest radiographs, and their assessment at the level of the lung lobule. The aim of the study was the assessment of typical findings in HRCT in lymphangitis carcinomatosa, enabling differential diagnosis. Read More

Clin Nucl Med 2005 Sep;30(9):615-6

Department of Radiology, Montefiore Medical Center, Bronx, New York 10467, USA.

Lymphangitic spread of metastases has distinct patterns on pulmonary scintigraphy and radiographic imaging. A 43-year-old woman with metastatic breast cancer presented with shortness of breath. Symptomatology was studied with ventilation and perfusion (V/Q) scintigraphy, chest radiograph, and computed tomography (CT). Read More

J Comput Assist Tomogr 2005 May-Jun;29(3):346-9

Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

Objective: The purpose of this study was to evaluate the F-fluorodeoxyglucose (FDG) positron emission tomography (PET) uptake in pulmonary lymphangitic carcinomatosis identified on computed tomography (CT) in patients with lung cancer.

Methods: This was a retrospective analysis of F-FDG PET images in 7 patients (4 male and 3 female, mean age: 56.6 +/- 6. Read More

Curr Probl Diagn Radiol 2005 Mar-Apr;34(2):63-75

Department of Radiolology, SDI UDIAT-CD, Institut Universitari Parc Taulí-UAB, Barcelona, Spain.

Central bronchi and pulmonary arteries are surrounded and enveloped by a strong connective-tissue sheath termed the peribronchovascular interstitium, extending from the level of the pulmonary hila into the peripheral lung. Thickening of the peribronchovascular interstitium can be seen in a wide variety of diseases. The CT appearance can be smooth, nodular, or irregular depending on the underlying cause. Read More

Ann Univ Mariae Curie Sklodowska Med 2003 ;58(2):370-7

2nd Department of Radiology, Medical University of Lublin.

High resolution computed tomography (HRCT) enables imaging of morphological changes invisible on plain chest radiograms or conventional CT. This is related to thin collimations of the scans and sharp (bone) algorithm of image reconstruction. In HRCT the lung interstitium may be evaluated at the level of the smallest functional unit, namely pulmonary lobule. Read More

Radiographics 2004 Jul-Aug;24(4):985-97; discussion 998

Department of Radiology, College of Medicine, Hanyang University, Seoul, Korea.

Radiation-induced lung disease (RILD) due to radiation therapy is common. Radiologic manifestations are usually confined to the lung tissue within the radiation port and are dependent on the interval after completion of treatment. In the acute phase, RILD typically manifests as ground-glass opacity or attenuation or as consolidation; in the late phase, it typically manifests as traction bronchiectasis, volume loss, and scarring. Read More

Int J Gynecol Cancer 2002 Mar-Apr;12(2):208-13

Department of Obstetrics and Gynecology, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

The objective of this article is to investigate the clinical features of pulmonary metastasis (PM) from endometrial adenocarcinoma, in particular, the predictors of prolonged survival after PM detection. Fifteen patients who developed PM and underwent chest computed tomography (CT) scans for evaluation of PM were studied: 12 patients with pulmonary recurrence and 3 patients with PM on presentation. All patients with bilateral nodules or lymphangitic spread had metastases in other sites prior to or concomitant with PM, most of which were detected in para-aortic lymph nodes and/or the vaginal wall, while only one of five patients with a limited number (n < or = 5) of unilateral nodules had these metastases. Read More

Radiol Clin North Am 2001 Nov;39(6):1115-35

Department of Radiology, Graduate Medicine Education, University of Wisconsin Medical School and Hospital and Clinics, Madison 53792-3252, USA.

The ground-glass pattern is a common but nonspecific finding on CT. In certain clinical circumstances, it can suggest a specific diagnosis, indicate a potentially treatable disease, and guide a clinician to an appropriate area for biopsy. A pattern of centrilobular ground-glass nodules is fairly specific for the diagnosis of hypersensitivity pneumonitis with the appropriate clinical history. Read More

Yonsei Med J 2001 Oct;42(5):497-502

Department of Diagnostic Radiology, Pundang CHA General Hospital, Pochon CHA University, College of Medicine, 351 Yatap-Dong, Pundang-Gu, Sungnam, Kyonggido 463-712, Korea.

The purpose of this study was to evaluate imaging findings of metastatic disease to the breast. We analyzed 15 cases that had been previously examined by radiographic study (comprising a total of 11 mammograms, 13 ultrasounds and 3 chest CT). Primary malignancies included the following: 6 breast cancers, 5 stomach cancers, 2 melanomas, 1 cervical cancer, and 1 lung cancer. Read More

Clin Nucl Med 2001 Nov;26(11):953-4

Departments of Nuclear Medicine, Pathology, and Pneumology, Saint-John's General Hospital, Brugge, Belgium.

Zhonghua Jie He He Hu Xi Za Zhi 1998 Dec;21(12):739-41

Departments of Respiratory Medicine and Pathology, People's Hospital, Beijing Medical University, Beijing 100044.

Objective: To explore the clinical manifestations of pulmonary lymphangitic carcinomatosis (PLC), to analyse its associated diagnostic methods, and to improve the understanding of PLC and its diagnosis.

Method: Retrospective analysis of 4 cases of PLC and review of the literature.

Result: The clinical manifestations of PLC include: (1) dyspnea and cough; (2) normal or restrictive pattern ventilation; (3) diffuse or local reticulonodular infiltrates in the lung like interstitial fibrosis and pleural effusion on chest radiograph; (4) CT and high-resolution CT (HRCT) scans reveal a beaded chain appearance caused by uneven thickening of the interlobular septa and pleural membrane, polygonal thickening of bronchovascular bundles, and mediastinal lymphadenopathy as well. Read More