393 results match your criteria Lymphangitic Carcinomatosis Imaging


Cutaneous Mycobacterial Infections.

Clin Microbiol Rev 2018 Jan 14;32(1). Epub 2018 Nov 14.

Servicio de Dermatología y Departamento de Micología, Hospital General de México, Mexico City, Mexico.

SUMMARYHumans encounter mycobacterial species due to their ubiquity in different environmental niches. In many individuals, pathogenic mycobacterial species may breach our first-line barrier defenses of the innate immune system and modulate the activation of phagocytes to cause disease of the respiratory tract or the skin and soft tissues, sometimes resulting in disseminated infection. Cutaneous mycobacterial infections may cause a wide range of clinical manifestations, which are divided into four main disease categories: (i) cutaneous manifestations of infection, (ii) Buruli ulcer caused by and other related slowly growing mycobacteria, (iii) leprosy caused by and , and (iv) cutaneous infections caused by rapidly growing mycobacteria. Read More

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January 2018
3 Reads

Cutaneous lymphangitic carcinomatosis: A rare metastasis from cervical cancer.

Gynecol Oncol Rep 2018 Nov 2;26:1-3. Epub 2018 Aug 2.

Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Bogotá, Colombia.

Skin metastases are a rare event in patients with cervical cancer. One form of such metastasis is carcinomatous lymphangitis, which is a rare presentation of skin metastases. Here we report a woman with cervical cancer diagnosed cutaneous lymphangitic carcinomatosis. Read More

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November 2018
3 Reads

Successfully treatment by eribulin in visceral crisis: a case of lymphangitic carcinomatosis from metastatic breast cancer.

BMC Cancer 2018 Aug 20;18(1):839. Epub 2018 Aug 20.

Department of Oncology, Ramsay Général de Santé, Hopital Privé Sainte Marie, 4 Allée de Saint-Jean-des-Vignes, 71100, Chalon-sur-Saône, France.

Background: Metastatic breast cancer (MBC) rest an incurably disease associated with bad prognosis and a median overall survival of 23-31 months. There are several treatment options including chemotherapy and sometimes endocrine therapy. Currently, there is no standard treatment for patients with MBC who have already benefited from anthracyclines and taxanes therapy. Read More

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August 2018
8 Reads

Pulmonary Lymphangitic Carcinomatosis From Renal Cell Carcinoma.

Curr Probl Diagn Radiol 2018 Jul 23. Epub 2018 Jul 23.

University of Florida, Division of Pulmonary, Critical Care and Sleep Medicine, Gainesville, FL. Electronic address:

Lymphangitic carcinomatosis, the presence of tumor within the pulmonary lymphatics, occurs in the setting of malignant tumors and is associated with a poor prognosis. Here we describe a case of lymphangitic carcinomatosis in the setting of renal cell carcinoma and review the radiological manifestations of this disease. Read More

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Inflammatory breast cancer and chest wall disease: The oncologist perspective.

Eur J Surg Oncol 2018 08 22;44(8):1142-1147. Epub 2018 May 22.

University of Milano, Department of Oncology and Hemato-Oncology, Division of Early Drug Development for Innovative Therapies, Istituto Europeo di Oncologia, Via Ripamonti 435, 20141 Milano, Italy. Electronic address:

Chest wall inflammatory and lymphangitic breast cancer represents a clinical spectrum and a model disease. Inflammation and the immune response have a role in the natural history of this special clinical presentation. Preclinical models and biomarker studies suggest that inflammatory breast cancer comprises a more important role for the tumour microenvironment, including immune cell infiltration and vasculogenesis, especially lympho-angiogenesis. Read More

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August 2018
8 Reads

Pulmonary lymphangitic carcinomatosis with ground-glass opacities as presentation of prostate cancer.

Respirol Case Rep 2018 Oct 26;6(7):e00347. Epub 2018 Jun 26.

Department of Respiratory Medicine Shonan Fujisawa Tokushukai Hospital Fujisawa Japan.

There is a broad differential diagnosis for interstitial shadows on chest computed tomography in rheumatoid arthritis patients, especially those previously treated with immunosuppressant drugs. We report an immunocompromised rheumatoid arthritis patient in respiratory failure with diffuse ground-glass opacities (GGOs), who was diagnosed with pulmonary lymphangitic carcinomatosis as the initial presentation of prostate cancer. He was successfully treated with chemohormonal androgen deprivation therapy, including bicalutamide, leuprorelin acetate, denosumab, and docetaxel. Read More

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October 2018
1 Read

A Rare Case of Isolated Chronic Cough Caused by Pulmonary Lymphangitic Carcinomatosis as a Primary Manifestation of Rectum Carcinoma.

Intern Med 2018 Sep 18;57(18):2709-2712. Epub 2018 May 18.

Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Japan.

A 36-year old man was referred to our hospital due to isolated chronic cough that was refractory to anti-asthma medications, including inhaled corticosteroids/long-acting β agonists. Chest X-ray showed diffuse nodular and enhanced vascular shadows with Kerley lines in both lungs. A blood analysis showed elevated serum carcinoembryonic antigen (CEA) and CA19-9 levels. Read More

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September 2018
0.970 Impact Factor

Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report.

BMC Cancer 2018 03 16;18(1):300. Epub 2018 Mar 16.

Department of Radiology, Japanese Red Cross Kochi Hospital, 2-13-51, Shinhonmachi, Kochi-city, Kochi, 780-8562, Japan.

Background: Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data have not been reported. Read More

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March 2018
15 Reads

A Case of Lung Adenocarcinoma with Marked Improvement of Pulmonary Lymphangitic Carcinomatosis by Adding Bevacizumab to Cisplatin and Pemetrexed.

Case Rep Oncol 2017 Sep-Dec;10(3):1065-1069. Epub 2017 Nov 27.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

A 40-year-old man with a diagnosis of lung adenocarcinoma (cT4N3M1c, stage IVB) experienced worsening of lymphangitic carcinomatosis in the right lung and right pleural effusion after receiving 1 cycle of first-line chemotherapy consisting of cisplatin and pemetrexed. Bevacizumab was thus added from the second cycle of the cisplatin-pemetrexed regimen, leading to a marked improvement in pulmonary lymphangitic carcinomatosis and a decrease in pleural effusion. Subsequently, maintenance therapy consisting of pemetrexed and bevacizumab was continued, successfully leading to long-term progression-free survival. Read More

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November 2017
1 Read

A Rare Case of Progressive Dyspnea and Bilateral Lung Infiltration in a Young Male.

Turk Thorac J 2017 Jul 1;18(3):96-99. Epub 2017 Jul 1.

Clinic of Chest Diseases, Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey.

Pulmonary lymphangitic carcinomatosis (PLC) is defined as infiltration of the lymphatic vessels and perilymphatic connective tissue with tumor cells, which is secondary to malignancy. Therefore, it rarely appears as an initial finding preceding a diagnosis of malignancy. A 30-year-old male patient was hospitalized in our clinic with a pre-diagnosis of interstitial lung disease owing to the complaints of dry cough, progressive dyspnea, and acute respiratory insufficiency. Read More

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July 2017
1 Read

Lymphangitic Carcinomatosis From Prostate Cancer Identified With Gallium-68 Prostate-specific Membrane Antigen Positron Emission Tomography Imaging.

Urology 2018 Apr 29;114:e1-e2. Epub 2017 Dec 29.

Department of Nuclear Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

Lymphangitic carcinomatosis refers to the rare process of diffuse malignant invasion of the pulmonary lymphatics. We describe the first reported case of lymphangitic carcinomatosis visualized with gallium-68 prostate-specific membrane antigen positron emission tomography and its clinical significance in a 53-year-old man with prostate carcinoma. This case highlights the ability of gallium-68 prostate-specific membrane antigen positron emission tomography for prostate carcinoma characterization and the importance of always considering atypical patterns of metastatic disease. Read More

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April 2018
5 Reads

A Rare Case of Pulmonary Lymphangitic Carcinomatosis in a Young Adult with Carcinoma Stomach.

J Clin Diagn Res 2017 Aug 1;11(8):OD07-OD09. Epub 2017 Aug 1.

Postgraduate Student, Department of General Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Pulmonary Lymphangitic Carcinomatosis (PLC) occurs in about 6-8% of patients with lung metastasis and may rarely develop in the course of gastric cancer representing a complication due to diffuse metastasis in the lymphatics of the lungs. A 29-year-old female, admitted with difficulty in breathing and productive cough for one week, was initially evaluated for respiratory tract infection. During evaluation of associated anaemia an upper gastrointestinal endoscopy showed large ulcerative growth in the lesser curvature of the stomach suggestive of carcinoma. Read More

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Excellent Response with Ado-Trastuzumab Emtansine in a Patient with Relapsed Metastatic Breast Cancer Presenting with Pulmonary Lymphangitic Carcinomatosis.

Cureus 2017 Jul 14;9(7):e1473. Epub 2017 Jul 14.

Department of Hematology and Oncology, William Beaumont Hospital, Oakland University William Beaumont School of Medicine.

In breast cancer, aggressive tumor biology and the corresponding poor prognosis is associated with amplification or overexpression of the human epidermal growth factor receptor 2 (HER2). Trastuzumab has significantly changed the natural history of HER2-positive breast cancer. However, resistance to trastuzumab remains a substantial clinical problem. Read More

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July 2017
5 Reads

Dramatic mixed response of lymphangitic pulmonary metastases in newly diagnosed prostate cancer.

Urol Ann 2017 Jul-Sep;9(3):278-280

Department of Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.

Prostate adenocarcinoma, the most common cancer in males in the United States, is often diagnosed in the nonmetastatic setting. The prognosis with metastatic prostate cancer is less favorable, though treatment options are typically effective in controlling the disease for an extended period. Hormonal therapy is the backbone to the management of prostate cancer metastases, decreasing the level of the prostate-specific antigen and reducing the patient's cancer-related symptoms. Read More

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August 2017
2 Reads

Multidetector CT for Evaluation of the Extrapleural Space.

Radiographics 2017 Sep-Oct;37(5):1352-1370. Epub 2017 Aug 4.

From the Department of Radiology, Hospital Naval Almirante Nef, Subida Alessandri S/N, Viña del Mar 2520000, Chile (M.G.S., G.V.L.H.); Departments of Radiology (M.G.S.) and Pathology (H.O.S.), Hospital Dr Eduardo Pereira, Valparaíso, Chile; Department of Radiology, Pontificia Universidad Católica de Chile, Santiago, Chile (I.B.); Department of Pathology, Universidad Andrés Bello, Viña del Mar, Chile (H.O.S.); and Department of Diagnostic Imaging Centro Rossi, Buenos Aires, Argentina (M.M.V.).

The extrapleural space (EPS) is an anatomic space at the periphery of the chest that can be involved in a number of disease processes. This space lies between the inner surface of the ribs and the parietal pleura and contains adipose tissue, loose connective tissue, lymph nodes, vessels, endothoracic fascia, and the innermost intercostal muscle. It is often overlooked on cross-sectional imaging studies and almost invariably overlooked on conventional radiographic studies. Read More

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December 2017
10 Reads

The prognostic impact of additional intrathoracic findings in patients with cancer-related pulmonary embolism.

Clin Transl Oncol 2018 Feb 10;20(2):230-242. Epub 2017 Jul 10.

Hematology and Medical Oncology Department, Hospital Universitario Morales Meseguer, Murcia, Spain.

Aim: To assess the prevalence and prognostic significance of additional intrathoracic findings (AIFs) in patients with cancer and pulmonary embolism (PE). AIFs were considered alterations other than the characteristic ones intrinsic to PE or changes in cardiovascular morphology.

Methods: Subjects have been taken from a Spanish national multidisciplinary and multicenter study of PE and cancer who were treated between 2004 and 2015. Read More

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February 2018
1 Read

Imaging of renal medullary carcinoma in children and young adults: a report from the Children's Oncology Group.

Pediatr Radiol 2017 Nov 8;47(12):1615-1621. Epub 2017 Jul 8.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway, Campus Box 8131, St. Louis, MO, 63110, USA.

Background: Renal medullary carcinoma is a rare renal malignancy of childhood. There are no large series describing the imaging appearance of renal medullary carcinoma in children.

Objective: To characterize the clinical and imaging features of pediatric renal medullary carcinoma at initial presentation. Read More

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November 2017
13 Reads

Lymphangitic Pulmonary Metastasis: A Rare Finding in Gastric Carcinoma.

J Clin Diagn Res 2017 May 1;11(5):OJ01. Epub 2017 May 1.

Attending Physician, Department of Pulmonary and Critical Care Medicine, Cleveland ClinicFlorida, 2950; Cleveland Clinic, Boulevard, Weston, FL 33331, USA.

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May 2017
3 Reads

Bilateral diffuse grade 5 radiation pneumonitis after intensity modulated radiation therapy for localized lung cancer.

World J Clin Oncol 2017 Jun;8(3):285-288

Virginia W Osborn, Andrea Leaf, Anna Lee, Elizabeth Garay, Joseph Safdieh, David Schwartz, David Schreiber, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY 11209, United States.

We are reporting a case of fatal radiation pneumonitis that developed six months following chemoradiation for limited stage small cell lung cancer. The patient was a 67-year-old man with a past medical history of Hashimoto's thyroiditis and remote suspicion for CREST, neither of which were active in the years leading up to treatment. He received 6600 cGy delivered in 200 cGy daily fractions intensity modulated radiation therapy with concurrent cisplatin/etoposide followed by additional chemotherapy with dose-reduced cisplatin/etoposide and carboplatin/etoposide and then received prophylactic cranial irradiation. Read More

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June 2017
14 Reads

Malignant Pleural Mesothelioma with Marked Lymphatic Involvement: A Report of Two Autopsy Cases.

Case Rep Oncol Med 2017 29;2017:6195898. Epub 2017 May 29.

Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

We herein report two cases of malignant pleural mesothelioma with marked lymphangiosis. The patients included a 68-year-old man and a 67-year-old man who both had a history of exposure to asbestos. Computed tomography (CT) on admission showed pleural effusion with pleural thickening. Read More

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May 2017
1 Read

Esophageal Metastasis from Rectal Cancer Successfully Treated with Fluorouracil-Based Chemotherapy with Bevacizumab: A Case Report and Review of the Literature.

Case Rep Oncol 2017 May-Aug;10(2):407-415. Epub 2017 May 5.

Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.

Esophageal metastasis from colorectal carcinoma is uncommon, and diagnosis of esophageal metastasis is difficult. We report a case of a 54-year-old woman with postoperative recurrence of rectal cancer metastasizing to the esophagus. She underwent rectectomy and adjuvant chemotherapy with fluorouracil, leucovorin plus oxaliplatin for stage IIIB rectal cancer. Read More

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May 2017
3 Reads

Surgical treatment of recidivist lymphedema.

Open Med (Wars) 2016 23;11(1):121-124. Epub 2016 Jun 23.

Department of Surgery, S. Andrea Hospital, La Spezia, Italy.

Lymphedema is a chronic disease with a progressively ingravescent evolvement and an appearance of recurrent complications of acute lymphangitic type; in nature it is mostly erysipeloid and responsible for a further rapid increase in the volume and consistency of edema. The purpose of this work is to present our experience in the minimally invasive treatment for recurrence of lymphedema; adapting techniques performed in the past which included large fasciotomy with devastating results cosmetically; but these techniques have been proposed again by the use of endoscopic equipment borrowed from the advanced laparoscopy surgery, which allows a monoskin access of about one cm. Read More

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June 2016
5 Reads

Nonbacterial Causes of Lymphangitis with Streaking.

J Am Board Fam Med 2016 11;29(6):808-812

From the New York University School of Medicine, New York, NY (BEC); and the Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York (ARN, MKP).

Background: Lymphangitic streaking, characterized by linear erythema on the skin, is most commonly observed in the setting of bacterial infection. However, a number of nonbacterial causes can result in lymphangitic streaking. We sought to elucidate the nonbacterial causes of lymphangitic streaking that may mimic bacterial infection to broaden clinicians' differential diagnosis for patients presenting with lymphangitic streaking. Read More

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November 2016
8 Reads

CT findings of small cell lung carcinoma: Can recognizable features be found?

Medicine (Baltimore) 2016 Nov;95(47):e5426

aDepartment of Radiology, CHA Bundang Medical Center, CHA University, Yatap-dong, Bundang-gu, Seongnam-si, Gyeonggi-do bDepartment of Radiology, St. Mary Dain Hospital, Mangpo-dong, Youngtong-gu, Suwon-si cDepartment of Radiology, Seoul National University Hospital, Daehak-ro, Jongno-gu, Seoul, Republic of Korea.

The purpose of this study was to clarify the recognizable computed tomography (CT) features of small cell lung carcinoma (SCLC).Contrast enhanced CT scans were reviewed retrospectively for mass location, mediastinal extension, and other concomitant findings in 142 patients with pathologically proven SCLC. SCLC was classified into hilar mass only (type I), hilar mass with ipsilateral mediastinal extension (type II), hilar mass with bilateral mediastinal extension (type III), and peripheral mass (type IV). Read More

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November 2016
10 Reads

Primary systemic amyloidosis: imaging interpretation of this complex multisystemic disease.

Authors:
Indu Mitra Ken Tung

BJR Case Rep 2016 2;2(4):20150171. Epub 2016 Nov 2.

Southampton University Hospital NHS Trust, Southampton, UK.

This report highlights the diagnostic complexities involved in the case of a 63-year-old female who presented with a non-productive cough and shortness of breath on exertion. Initial chest radiograph demonstrated generalized abnormal interstitial lung markings with thickened peripheral septal lines. Further characterization was sought by CT scan of the chest, and given the possibility of lymphangitic carcinomatosis, a CT scan of the abdomen and pelvis was also performed. Read More

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November 2016
2 Reads

Prolonged Survival in Colon Cancer with Malignant Pericardial Effusion and Pulmonary Lymphangitic Carcinomatosis: A Case for Monoclonal Antibodies?

Conn Med 2016 Sep;80(8):483-485

Traditionally, cardiac metastases and lymphangitic carcinomatosis have been associated with survival of only two to four months. We report herein a patient with malignant pericardial. effusion, and lymphangitic carcinomatosis due to colon cancer who remains in partial remission 12 months after the diagnosis. Read More

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September 2016

Single benign metastasising leiomyoma of an inguinal lymph node.

BMJ Case Rep 2016 Aug 10;2016. Epub 2016 Aug 10.

Department of Gynaecological Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.

Benign metastasising leiomyoma (BML) is a rare benign disease associated with uterine leiomyoma and history of uterine surgery. It most frequently occurs in premenopausal woman, with a pulmonary localisation, and consisting of multiple nodules. We present an uncommon case of a 69-year-old woman with a single BML of an inguinal lymph node. Read More

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August 2016
2 Reads

Fluorodeoxyglucose Uptake in Advanced Non-small Cell Lung Cancer With and Without Pulmonary Lymphangitic Carcinomatosis.

Anticancer Res 2016 Aug;36(8):4313-20

Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan, R.O.C.

Aim: To assess the correlation between advanced non-small cell lung cancer (NSCLC) with or without pulmonary lymphangitic carcinomatosis (PLC) and fluorodeoxyglucose (FDG) uptake and its effect on survival outcomes.

Patients And Methods: We retrospectively reviewed 157 patients with NSCLC. The mean and maximum standardized uptake values (SUVmean and SUVmax, respectively), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were evaluated for their effect on overall survival (OS) and progression-free survival (PFS). Read More

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August 2016
5 Reads

Bronchoalveolar lavage cellular analyses in conjunction with high-resolution computed tomography imaging as a diagnostic intervention for patients with suspected interstitial lung disease.

Lung India 2016 May-Jun;33(3):287-91

Dualhelix Genetic Diagnostics, Chennai, Tamil Nadu, India; Vasan Medical Research Trust, Chennai, Tamil Nadu, India.

Background: Bronchoalveolar lavage (BAL) has gained acceptance for diagnosis of Interstitial lung disease (ILD). The advent of high-resolution computed tomography (HRCT) has reduced the clinical utility of BAL. This work has utilized the recommendations of the American Thoracic Society (ATS) to optimize BAL and the findings have been associated with clinical examination and HRCT to precisely narrow down the cause of ILD. Read More

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Pathology analysis of a rare case of diffuse pulmonary lymphangiomatosis.

Ann Transl Med 2016 Mar;4(6):114

The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Guangzhou Medical University, China), Guangzhou Institute of Respiratory disease, Guangzhou 510120, China.

Diffuse pulmonary lymphangiomatosis (DPL) is a rare lymphatic disorder characterized by uncontrolled proliferation of lymphatic vessels. Histologically benign, however, it can lead to death because of its progression. In this paper, we would like to present an unusual case of diffuse pulmonary lymphangiomatosis involving a 28-year-old young female who was suffered chest pain and polypnea for one year, and also a lot of chylous effusion in left chest. Read More

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March 2016
2 Reads

Pulmonary Resection for Metastatic Gastric Cancer.

Ann Thorac Cardiovasc Surg 2016 Aug 27;22(4):230-6. Epub 2016 Apr 27.

Division of Thoracic Surgery, Saitama Cancer Center, Saitama, Japan.

Background: Pulmonary metastasectomy has come to be recognized as an effective treatment for selected patients with some malignancies. On the other hand, the role of pulmonary metastasectomy for gastric cancer is still unknown. Metastasectomy is rarely indicated in cases of pulmonary metastasis from gastric cancer, because in most cases, the metastasis occurs in the form of lymphangitic carcinomatosis and the lesions are numerous. Read More

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August 2016
1 Read

Lymphangitic papules caused by Nocardia takedensis.

JAAD Case Rep 2015 May 2;1(3):126-8. Epub 2015 May 2.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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May 2015
8 Reads

Spectral Manifestation of Melanized Fungal Infections in Kidney Transplant Recipients: Report of Six Cases.

Mycopathologia 2016 Jun 30;181(5-6):379-85. Epub 2016 Mar 30.

Department of Dermatology, Federal University of São Paulo (UNIFESP), Rua Borges Lagoa, 508, São Paulo, SP, CEP 04038-001, Brazil.

Chromoblastomycosis and phaeohyphomycosis are melanized fungal infections, which affect skin and subcutaneous tissues in immunocompetent and immunosuppressed patients, as solid-organ transplant recipients, respectively. In this present study, we report six cases of melanized fungal infection in kidney transplant recipients. In five cases, culture of tissue specimens identified two cases of Exophiala spp. Read More

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June 2016
3 Reads

Occult pulmonary lymphangitic carcinomatosis presenting as 'chronic cough' with a normal HRCT chest.

Ann Med Surg (Lond) 2016 Mar 1;6:77-80. Epub 2016 Feb 1.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.

A diagnosis of 'chronic cough' (CC) requires the exclusion of sinister pulmonary pathology, including infection and malignancy. We present a patient with a 3 month history of CC who had an extensive workup including a normal high resolution computed tomography of the chest (HRCT) 6 weeks prior to consultation at our center. He subsequently developed constitutional symptoms including weight loss and loss of appetite 5 weeks after initial consultation. Read More

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March 2016
1 Read

An interesting case of profound hypoxemia.

Exp Mol Pathol 2016 Apr 2;100(2):321-4. Epub 2016 Mar 2.

Department of Internal Medicine, Harbor UCLA Medical Center, Torrance, CA, USA.

A 58 year old male with a history of cirrhosis (hepatitis B and C), a long smoking history, and a recently diagnosed high-grade transitional cell carcinoma of the bladder wall presented three days after a biopsy procedure with abdominal pain, nausea, and new hypoxemia on room air. The chest radiograph was clear and the CT angiogram showed only a borderline large pulmonary artery, two small nodules (3mm and 4mm) in the right middle lobe of the lung, and emphysematous changes throughout the lung parenchyma. There was no evidence of pulmonary embolism. Read More

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April 2016
5 Reads

Distinctive Patterns of Initially Presenting Metastases and Clinical Outcomes According to the Histological Subtypes in Stage IV Non-Small Cell Lung Cancer.

Medicine (Baltimore) 2016 Feb;95(6):e2795

From the Department of Radiation Oncology (DSL, YSK, CSK, SHK); Division of Pulmonology (CDY, JWK, SJK, YKK), Department of Internal Medicine; Division of Medical Oncology (YHK, JHK), Department of Internal Medicine; Department of Hospital Pathology (KYL); and The Cancer Research Institute (SJK), College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, South Korea.

This study was designed to compare the primary patterns of metastases and clinical outcomes between adenocarcinoma (Adenoca) and squamous cell carcinoma (SQ) in initially diagnosed stage IV non-small cell lung cancer (NSCLC).Between June 2007 and June 2013, a total of 427 eligible patients were analyzed. These patients were histologically confirmed as Adenoca or SQ and underwent systemic imaging studies, including 18F-fluorodeoxyglucose positron emission tomography/computed tomography and brain imaging. Read More

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February 2016
29 Reads

Impact of histologic subtype and sarcomatoid transformation on metastasis in renal cell carcinoma: a single institute experience in 149 patients.

Abdom Radiol (NY) 2016 Feb;41(2):295-302

Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.

Purpose: To compare the metastatic pattern and outcome of clear cell RCC (ccRCC) and papillary RCC (pRCC), and to assess the impact of sarcomatoid transformation on the disease spread and prognosis.

Materials And Methods: This IRB-approved, HIPAA-compliant retrospective study included 149 consecutive patients (108 men; mean age 58 years; range 25-86) with metastatic RCC (ccRCC = 116, pRCC = 33), identified from imaging database. All available imaging studies and electronic records of these patients were reviewed to document pathological features, distribution and timing of metastasis, and survival. Read More

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February 2016
8 Reads

Occult Dermal Lymphatic Involvement Is Frequent in Primary Cutaneous Anaplastic Large Cell Lymphoma.

Am J Dermatopathol 2015 Oct;37(10):767-70

Departments of *Pathology, †Radiation Oncology, and ‡Dermatology, Stanford University School of Medicine, Stanford, CA.

Primary cutaneous anaplastic large cell lymphoma (pcALCL) is an indolent T-cell lymphoproliferative disorder managed with low-dose radiation therapy, surgery, and/or mild chemotherapy; patients with extensive limb disease (ELD) have a more aggressive clinical course. We have previously demonstrated that histologically apparent vascular involvement in pcALCL is lymphatic. We hypothesized that histologically occult lymphatic involvement may be associated with particular patterns of disease spread that could involve lymphangitic spread including locoregional spread of disease in the form of ELD and extracutaneous spread of disease. Read More

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October 2015

Maintaining sharp focus on a grainy film: miliary pattern in an elderly woman with acute respiratory failure.

BMJ Case Rep 2015 Jul 22;2015. Epub 2015 Jul 22.

Division of Immunology, University of Iowa, Iowa City, Iowa, USA.

An elderly woman with a history of pulmonary tuberculosis reportedly diagnosed and treated 30 years prior to presentation was found unresponsive at home. Chest imaging revealed innumerable pulmonary nodules worrisome for an infectious process, specifically tuberculosis. The patient deteriorated rapidly and in accordance with her wishes, aggressive interventions were withheld. Read More

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July 2015
1 Read

Histopathology of Explanted Lungs From Patients With a Diagnosis of Pulmonary Sarcoidosis.

Chest 2016 Feb 12;149(2):499-507. Epub 2016 Jan 12.

Department of Pathology, University of Michigan Health Systems, Ann Arbor, MI.

Background: Pathologic features of end-stage pulmonary sarcoidosis (ESPS) are not well defined; anecdotal reports have suggested that ESPS may mimic usual interstitial pneumonia (UIP). We hypothesized that ESPS has distinct histologic features.

Methods: Twelve patients who received a diagnosis of pulmonary sarcoidosis and underwent lung transplantation were included. Read More

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February 2016
3 Reads

Pulmonary lymphangitic carcinomatosis from metastatic gastric adenocarcinoma: case report.

J Am Osteopath Assoc 2015 May;115(5):332-7

Pulmonary lymphangitic carcinomatosis (PLC) is the diffuse infltration of lymphatic systems by adenocarcinomas. Because of its vague clinical symptoms and absence of malignant features, confrmatory diagnosis requires transbronchial or open-lung biopsy. Tumor spread is postulated to occur by means of retrograde lymphatic permeation with tumor growth along the lymphatic channels and involvement of vascular endothelial growth factor-C in a signaling pathway. Read More

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Getting the whole picture: lymphangitic carcinomatosis.

Am J Med 2015 Aug 23;128(8):837-40. Epub 2015 Apr 23.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville.

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August 2015
2 Reads

Antiangiogenic therapy in recurrent breast cancer with lymphangitic spread to the chest wall: A randomized phase II trial of bevacizumab with sequential or concurrent oral vinorelbine and capecitabine.

Breast 2015 Jun 12;24(3):263-71. Epub 2015 Mar 12.

Division of Experimental Therapeutics, Breast Health Program, Istituto Europeo di Oncologia, Italy.

Objectives: To assess efficacy of bevacizumab in combination with oral chemotherapy in patients with breast cancer with lymphangitic spread to the chest wall (LBC). To identify surrogate biomarkers of response to bevacizumab.

Patients And Methods: We randomly assigned patients to receive bevacizumab plus either sequential or concurrent oral vinorelbine and capecitabine every 3 weeks. Read More

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June 2015
9 Reads

[A case of colorectal cancer with pelvic recurrence treated by systemic chemotherapy and radiotherapy].

Gan To Kagaku Ryoho 2014 Nov;41(12):1719-21

Dept. of Gastroenterological Surgery, Aichi Medical University Hospital.

A 63-year-old man who had a history of rectal cancer and was treated with low anterior resection in February 2006, presented with liver metastases in September 2007 and underwent right anterior sectionectomy of the liver. He developed a pelvic wall recurrence with buttock pain in September 2009. This was treated with conventional radiation therapy and Cyber- Knife. Read More

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November 2014
3 Reads

Lymphangitic spread from the appendiceal adenocarcinoma to the ileocecal valve, mimicking Crohn's disease.

World J Gastroenterol 2015 Feb;21(7):2206-9

Tricia Murdock, Maryam Zenali, Department of Pathology, University of Vermont-College of Medicine/Fletcher Allen Health Care, Burlington, VT 05401, United States.

Due to the anatomical peculiarity of the appendix, diagnosis of tumors arising from this area can be challenging by clinicoradiologic means. We report a case of a rare primary appendiceal signet ring carcinoma with an uncommon presentation. An 86-year-old woman was admitted to our hospital with subacute epigastric pain. Read More

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February 2015
4 Reads

Hepatic lymphatics: anatomy and related diseases.

Abdom Imaging 2015 Aug;40(6):1997-2011

Department of Radiology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva, Switzerland,

The liver normally produces a large amount of lymph. It is estimated that between 25% and 50% of the lymph received by the thoracic duct comes from the liver. In normal conditions, hepatic lymphatics are not depicted on cross-sectional imaging. Read More

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August 2015
3 Reads

Advanced adenocarcinoma of the lung: comparison of CT characteristics of patients with anaplastic lymphoma kinase gene rearrangement and those with epidermal growth factor receptor mutation.

Radiology 2015 Apr 7;275(1):272-9. Epub 2015 Jan 7.

From the Departments of Pulmonary and Critical Care Medicine (C.M.C., W.S.K.), Oncology (C.M.C.), Radiology and Research Institute of Radiology (M.Y.K.), and Clinical Epidemiology and Biostatistics (J.B.L.), University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul 138-736, Korea; and Department of Radiology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Seoul, Korea (H.J.H.).

Purpose: To study the differences in computed tomographic (CT) characteristics between patients with advanced lung adenocarcinoma who have anaplastic lymphoma kinase (ALK) gene rearrangement and those who have epidermal growth factor receptor (EGFR) mutations.

Materials And Methods: This retrospective study was approved by the institutional review board. Informed consent was waived. Read More

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April 2015
35 Reads

A case series of patients with HER2-overexpressed primary metastatic gastroesophageal adenocarcinoma.

Anticancer Res 2014 Dec;34(12):7357-60

Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, U.S.A.

Background: Overexpression of the human epidermal growth factor 2 (HER2) is associated with an aggressive metastatic phenotype in patients with breast cancer but its prognostic impact is not well-characterized in gastroesophageal adenocarcinoma.

Patients And Methods: This is a retrospective series of three cases of HER2-positive gastroesophageal cancer.

Results: In this case series, we describe three patients presenting with widespread metastatic disease prior to development of symptoms from the primary tumor. Read More

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December 2014

RET-rearranged lung adenocarcinomas with lymphangitic spread, psammoma bodies, and clinical responses to cabozantinib.

J Thorac Oncol 2014 Nov;9(11):1714-9

*Departments of Pathology, †Solid Tumor Oncology, and ‖Translational Hematology and Oncology Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH; ‡Foundation Medicine, Cambridge, MA; and §Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY.

Oncogenic rearrangements of the RET gene have recently been described in 1% to 2% of lung adenocarcinomas. We report five cases of RET-rearranged lung adenocarcinoma with an unusual constellation of clinical and histologic features that has not previously been described in tumors with this genomic alteration. The age at diagnosis of the five patients (4F, 1M) ranged from 44 to 77 years. Read More

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November 2014
17 Reads

Recurrent lymphangitic cellulitis syndrome: A quintessential example of an immunocompromised district.

Clin Dermatol 2014 Sep-Oct;32(5):621-7

Department of Dermatology, Department of Pathology, University of Mississippi School of Medicine, Jackson, Mississippi; University of Rochester School of Medicine and Dentistry, Rochester, New York. Electronic address:

Recurrent lymphangitic cellulitis syndrome (RLCS) occurs when a disordered lymphatic system renders a leg vulnerable to recurrent infection. The underlying immunologic defect is the result of accidental or iatrogenic penetrating wounds on the medial aspect of the thigh or lower limb overlying the greater saphenous vein, because the primary lymphatic drainage vessels are adjacent to this structure. Cracking/fissuring of the skin associated with chronic fungal infection of the feet ("athlete's foot"), most commonly mixed bacterial/fungal interdigital involvement, provides a portal of entry for opportunistic organisms. Read More

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May 2015
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