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Medicina (Kaunas) 2022 May 30;58(6). Epub 2022 May 30.

Department of Endocrinology and Internal Medicine, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland.

The current high detection rate of adrenal tumors (4-10% of general population) is attributable to a widespread use of variety of imaging studies, especially a computed tomography. Most of them represent clinically silent and biologically indolent incidentalomas, but some adrenal tumors may pose a significant clinical challenge. Thus, in every patient with an adrenal tumor, a decision on further management is made after careful hormonal and radiological evaluation. Read More

Pediatr Dermatol 2022 Jun 23. Epub 2022 Jun 23.

Department of Dermatology, Henry Ford Health System, Detroit, Michigan, USA.

Microcystic lymphatic malformation (MiLM), also known as lymphangioma circumscriptum, is a superficial collection of lymphatic vessels measuring <1 cm in the largest diameter, often with a more extensive deeper malformation. It commonly presents as discrete or grouped plaques of clear or hemorrhagic vesicles classically described as "frogspawn"; however, here we describe a case of its unique presentation as firm papules on the lips of a healthy six-year-old child. These skin-colored papules in the absence of vesicles with lymphatic and/or hemorrhagic fluid may not be clinically indicative of MiLM. Read More

Andes Pediatr 2022 Apr;93(2):265-269

Hospital Universitario Politecnic La Fe, Valencia, España.

Cystic lymphatic malformation (CLM) is a rare and benign entity caused by alterations in the embryological development of lymphatic structures. Its typical location is in the head and neck, although it has also been described at the abdominal level. It may not be evident in the first stages of life and its first manifestation may be a complication such as abdominal distension, hemorrhage, or sepsis, which may put the patient's life at risk. Read More

Ann Med Surg (Lond) 2022 Jun 4;78:103917. Epub 2022 Jun 4.

Department of General Surgery, Mohamed VI University Hospital, Oujda, Morocco.

Introduction: Cystic lymphangioma is a benign malformation tumor of the lymphatic system. Its location is variable, and mesenteric localization remains extremely rare.

Case Presentation: We describe a rare case of cystic lymphangioma of the mesentery in a 26 years old woman. Read More

Laryngoscope Investig Otolaryngol 2022 Jun 22;7(3):751-756. Epub 2022 Apr 22.

Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital Qingdao University Yantai China.

Background: Cervical lymphangioma usually occurs in children and is relatively rare in adults. The purpose of this study was to investigate the characteristics of cervical lymphangiomas in adults.

Methods: We retrospectively reviewed the medical records and analyzed clinical data obtained from seven adult patients who suffered from cervical lymphangioma from January 2008 to June 2021. Read More

Plast Reconstr Surg Glob Open 2022 Jun 16;10(6):e4379. Epub 2022 Jun 16.

Plastic and Reconstructive Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Chylorrhea, a chylous (white viscid) discharge from the external urethral penile opening, is unrelated to urination and is a rare presentation of lymphangioma circumscriptum in the penis that can significantly impair a patient's quality of life and psychological well-being. Herein, we present a case of recurrent chylorrhea that was detected using diagnostic tools and treated using the deep external pudendal artery perforator flap in the inner thigh, which is extremely rich in lymphatic vessels and lymph nodes. Read More

J Indian Assoc Pediatr Surg 2022 May-Jun;27(3):354-356. Epub 2022 May 12.

Department of Pediatric Surgery, NRS Medical College, Kolkata, West Bengal, India.

Teratomas are common tumors in children. The most common sites are gonads, however, several extragonadal sites are well known such as sacrococcygeal region, mediastinum, head and neck, stomach, and vagina. Occasionally, teratomas occur in unusual sites which pose diagnostic difficulties. Read More

PLoS One 2022 22;17(6):e0269323. Epub 2022 Jun 22.

Department of Radiology and Medical Imaging, University of Ottawa, Ottawa, Canada.

Objective: To develop and internally validate a deep-learning algorithm from fetal ultrasound images for the diagnosis of cystic hygromas in the first trimester.

Methods: All first trimester ultrasound scans with a diagnosis of a cystic hygroma between 11 and 14 weeks gestation at our tertiary care centre in Ontario, Canada were studied. Ultrasound scans with normal nuchal translucency were used as controls. Read More

Lancet 2022 06;399(10343):2309

Department of Urology, Toulouse University Hospital, Toulouse, France.

J Med Case Rep 2022 Jun 19;16(1):242. Epub 2022 Jun 19.

Department of Surgery, Banner MD Anderson Cancer Center-Phoenix, University of Arizona College of Medicine-Phoenix, 925 East McDowell Rd., Phoenix, AZ, 85006, USA.

Background: Lymphangioma is a rare diagnosis in adult patients and typically presents in early infancy. These tumors are a result of malformation of the lymphatic vessels and usually involve the head, neck, and axilla.

Case Presentation: We report the case of a 28-year-old African female who recently immigrated from East Africa and presented to our surgical breast clinic with a large and rapidly growing left axillary mass. Read More

Case Rep Dent 2022 2;2022:7890338. Epub 2022 Jun 2.

Department of Oral and Maxillofacial Pathology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, India.

Hamartomas are tumor-like deformities typified by cellular propagation indigenous to the original site, although they display growth arrest without the possibility for further growth. Various hamartomatous oral lesions include hemangiomas, lymphangiomas, nevi, odontomas, Cherubism, etc. Lymphangiomas are benign, developmental hamartomatous entities typified by abnormal proliferation of lymphatic vessels. Read More

Case Rep Pathol 2022 17;2022:3033705. Epub 2022 May 17.

Department of Pathology, Manipal College of Medical Sciences, Pokhara, Nepal.

Lymphangioma is a benign tumor characterized by proliferation of thin-walled lymphatic spaces. Lymphangioma of the small-bowel mesentery is rare, with an incidence of 1 : 250,000, representing less than 1% of all lymphangiomas. The predilection of the tumor is in the head and neck (70%), axillary (20%), and internal organs (10%). Read More

Plast Reconstr Surg Glob Open 2022 May 24;10(5):e4348. Epub 2022 May 24.

Department of Plastic and Reconstructive Surgery, The International Center for Lymphedema, Hiroshima University Hospital, Hiroshima, Japan.

Several treatment options, including sclerotherapy and surgical excision, are available for the management of cystic lymphangioma. Lymphaticovenular anastomosis (LVA) has recently garnered attention in the field of microsurgery as a minimally invasive surgical reconstruction strategy. Combined treatment using surgical excision and LVA for large or persistent cystic lymphatic malformations has been reported but can be very invasive. Read More

Clin Case Rep 2022 May 12;10(5):e05839. Epub 2022 May 12.

Department of Pathology Imam Khomeini Hospital Tehran University of Medical Sciences Tehran Iran.

A 60-year-old woman presented with non-itchy shiny translucent papules on her right breast surface. She had a history of quadrantectomy and chemoradiotherapy due to medullary breast carcinoma 20 years ago. Cutaneous lymphangioma occurred secondary to surgery and radiotherapy 8 years ago. Read More

Acta Otorrinolaringol Esp (Engl Ed) 2022 May-Jun;73(3):199

Servicio de Otorrinolaringología, Hospital Quironsalud, Valencia, Spain. Electronic address:

Urology 2022 May 6. Epub 2022 May 6.

Section of Urology, Department of Surgery, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH. Electronic address:

Eur Arch Otorhinolaryngol 2022 May 8. Epub 2022 May 8.

Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Liebigstr. 12, 04103, Leipzig, Germany.

Purpose: Children with extensive lymphatic malformations of the head and neck often suffer from functional impairment and aesthetic deformity which significantly affect the quality of life and may be life-threatening. Treatment with sirolimus has the potential to improve symptoms and downsize lymphatic malformations. This systematic review summarizes the current information about sirolimus treatment of lymphatic malformations of the head and neck in children, its efficacy and side effects. Read More

Cureus 2022 Mar 31;14(3):e23702. Epub 2022 Mar 31.

Division of Pediatric Surgery, Department of Surgery, Naval Medical Center San Diego, San Diego, USA.

We report the case of a 17-year-old male who presented with intractable nausea and vomiting. Cross-sectional imaging revealed a large retrogastric abdominal mass. Fine needle aspiration done via endoscopic ultrasound (EUS) was nondiagnostic. Read More

Dermatol Online J 2021 Dec 15;27(12). Epub 2021 Dec 15.

Department of Dermatology, Mayo Clinic, Jacksonville, Florida, USA Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA..

Lymphangioendothelioma, also known as acquired progressive lymphangioma, is a rare vascular neoplasm of lymphatic origin. Although in light-skinned individuals lesions typically present as erythematous to violaceous papules or plaques, in dark-skinned patients lesions often appear hyperpigmented. Histopathologic distinction of lymphangioendothelioma from early Kaposi sarcoma and angiosarcoma is imperative considering the therapeutic and prognostic implications. Read More

ANZ J Surg 2022 Apr 30. Epub 2022 Apr 30.

Department of General Surgery, Christchurch Hospital, Christchurch, New Zealand.

Surgery 2022 Apr 26. Epub 2022 Apr 26.

HPB and Transplant Unit, Freeman Hospital, Newcastle Upon Tyne, UK; Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK. Electronic address:

Rev Esp Enferm Dig 2022 Apr 26. Epub 2022 Apr 26.

Cirugía General y del Aparato Digestivo, Hospital Universitario Torrecárdenas.

We report the exceptional case of a 71-year-old patient with a giant mesenteric mass causing mass effect, dyspnea and abdominal pain. After surgical resection and histopathological analysis of the specimen, the result was a cavernous lymphangioma, an unusual diagnosis due to both the location and age of presentation. Read More

GMS Ophthalmol Cases 2022 22;12:Doc09. Epub 2022 Mar 22.

M. N. Eye Hospital, Chennai, Tamil Nadu, India.

Lymphangiomas are benign hemartomatous tumors that can occur in all parts of the body, but most frequently in the neck (75%), as well as in the axilla and inguinal areas. Surgical removal is very difficult, as it is very fragile and tumor dissection is very difficult. Ultrasound-guided bleomycin injection directly into the cyst collapses the cyst and shrinks the tumor. Read More

Cureus 2022 Apr 7;14(4):x49. Epub 2022 Apr 7.

Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAU.

J Indian Soc Pedod Prev Dent 2022 Jan-Mar;40(1):86-89

Department of Paediatric Surgery, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Oral swellings and ulcers in neonates are a spectrum of diseases often creating a sense of anxiety among parents. Early detection, high index of suspicion, proper investigations, and prompt diagnosis can aid in accurate management of the same. Lymphangiomas are benign hamartomas which are basically malformed lymphatics do not drain into other lymphatics or veins and hence there is lymphatic accumulation and enlargement following cystically dilated spaces. Read More

Birth Defects Res 2022 06 15;114(10):499-504. Epub 2022 Apr 15.

APHp.Centre, Hopital Necker-Enfants Malades, Service de Médecine Génomique des Maladies Rares, Paris, France.

Background: The THOC6 protein is a component of the THO complex. It is involved in mRNA transcription, processing and nuclear export. Interestingly molecular biallelic loss-of-function variants of the THOC6 gene were identified in the Beaulieu-Boycott-Innes syndrome (BBIS- OMIM # 613680). Read More

J Cosmet Dermatol 2022 Apr 15. Epub 2022 Apr 15.

Department of Pathology, Inonu University, Malatya, Turkey.

HNO 2022 May 14;70(5):380-388. Epub 2022 Apr 14.

VASCERN HHT Reference Centre, Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg, Philipps-Universität Marburg, Marburg, Deutschland.

Background: A multitude of vascular anomalies exist and can lead to severe complications. Treatment can be complex.

Objective: This overview aims to provide important information for the management of vascular anomalies. Read More

Clin Nucl Med 2022 Apr 4. Epub 2022 Apr 4.

From the Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Abstract: As congenital lymphatic malformations, lymphangiomas commonly occur in the neck, tongue, and extremities, whereas scrotum is one of the least frequent sites. For this lymphatic flow disease, lymphoscintigraphy is regarded as a useful imaging method. Herein, in a child with scrotal cysts, scrotal region activity was detected in lymphoscintigraphy, consistent with likely lymphatic disorder. Read More

Ultraschall Med 2022 04 5;43(2):111-114. Epub 2022 Apr 5.

Centre for Ultrasound and Prenatal Medicine, Frankfurt/Main, Germany.