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Surg Today 2019 Feb 18. Epub 2019 Feb 18.

Department of Pediatric Surgery, Osaka Women's and Children's Hospital, 840, Murodocho, Izumi, Osaka, Japan.

Purpose: Airway obstruction caused by lymphatic malformation (LM) in the head and neck may require a tracheostomy. We present the results of our analysis of a nationwide survey on the indications for tracheostomy in children with head and neck LM.

Methods: We analyzed data in relation to tracheostomy based on a questionnaire about 518 children with head and neck LM without mediastinal involvement. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):141-142

Department of Otorhinolaryngology, Second Hospital of Dalian Medical University, Dalian 116027, China.

J Craniomaxillofac Surg 2018 Sep 20. Epub 2018 Sep 20.

University of Parma, Department of Maxillo Facial Surgery (Head: Prof. Enrico Sesenna), Italy.

Vascular malformations are often found inside the orbit. Isolated venous malformations (frequently misnamed as cavernous hemangiomas) are the most frequent among these. However, also lymphatic and arteriovenous malformations can affect the orbit. Read More

J Am Acad Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Pediatric Surgery, the Second Affiliated Hospital, Xi'an JiaoTong University, Xi'an 710004, China. Electronic address:

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Breast and Medical Oncology, National Cancer Center Hospital, Japan.

Objective Few reports have analyzed the diagnostic process of carcinoma of unknown primary site (CUP) or have focused on the frequency of nonmalignant lesions among patients with suspected malignant diseases. The aim of this study was to investigate the incidence and characteristics of nonmalignant diseases that tend to be mistaken for malignant diseases. Patients We retrospectively analyzed the medical records of patients with suspected CUP who were referred to the National Cancer Center Hospital (Tokyo, Japan) between April 2007 and December 2014. Read More

Basic Clin Androl 2019 28;29. Epub 2019 Jan 28.

3Department of Vattikuti Urology Institute, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 USA.

Background: Penile lymphangiomas are rare manifestations of lymphangiomas or lymphatic malformations which are more commonly found in the head or neck region of the body. Lymphangiomas are further categorized as lymphangioma circumscriptum, cavernous lymphangioma, cystic hygroma, or acquired lymphangiomas (also known as lymphangiectasia), based on their depth and etiology.

Results: A literature review revealed only 30 cases of penile lymphangioma between 1947 and March 30, 2018. Read More

J Surg Case Rep 2019 Jan 24;2019(1):rjy334. Epub 2019 Jan 24.

Department of General Surgery, Presence Saint Joseph Hospital, Chicago, IL, USA.

The etiology of pneumatosis cystoides intestinalis (PCI) is multifactorial and its corresponding treatment is similarly complex. One causation of PCI, is lymphatic disruption. This association is discussed in this case report involving an incident of abdominal lymphangioma and subsequent development of PCI in a 57-year-old female. Read More

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Naja Clinic, Department of Dermatology, Gilan, Rasht.

Lymphangioma circumscriptum is a developmental anomaly of lymphatic vessels, which appear as aggregates of clear or hemorrhagic vesicles on the skin or mouth. Glans penis involvement is very uncommon. Because of the sensitivity of the area, possible functional, cosmetic, or psychologic disturbances can result. Read More

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

Cutaneous mucinosis of infancy (CMI) is a rare dermatologic condition, first reported in 1980 and currently classified within the complex group of papular mucinoses. We report a case of CMI and review the prior 13 cases in the literature. The patient was a 5-year-old girl who presented with asymptomatic dermal papules and plaques on her leg and back with no overlying color change. Read More

Plast Reconstr Surg Glob Open 2018 Dec 13;6(12):e2059. Epub 2018 Dec 13.

Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo, Japan.

Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. We report a child who was initially diagnosed with lymphangioma and referred to our institute for sclerotherapy, only to find out that the tumor was in fact MASC after excision. This case of MASC is in a 7-year-old boy, the youngest case so far reported. Read More

Pediatrics 2019 Jan 17. Epub 2019 Jan 17.

St Louis Children's Hospital, St Louis, Missouri.

Methemoglobinemia occurs when the heme moiety of hemoglobin (Hb) is oxidized from the ferrous to ferric state, leading to impairments in oxygen transport and delivery. Methemoglobinemia is rare in pediatric patients but has been described in the setting of congenital abnormalities in the Hb structure, inherited enzyme deficiencies, oxidative Hb injury in response to illness, and oxidative Hb injury due to toxicants. We present a 1-week-old infant born with a cervical lymphangioma who developed persistent desaturations that were unresponsive to oxygen after sclerotherapy with doxycycline. Read More

J Surg Case Rep 2019 Jan 11;2019(1):rjy336. Epub 2019 Jan 11.

Department of Colorectal Surgery, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Background: Cystic lymphangiomas are rare benign tumours and their actual incidence in the colon is unclear. Within the large bowel, these lesions are often submucosal and are incidental findings on colonoscopy.

Case Report: A 43-year-old man with colonic lymphangioma presented with a 7-month history of abdominal pain and altered bowel habits. Read More

Medicine (Baltimore) 2019 Jan;98(2):e14000

Department of Cardiac Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, People's Republic of China.

Rationale: Cardiac lymphangioma is a rare disease. Until now, there have been only a few cases of cardiac lymphangioma reported in the literature.

Patient Concerns: We report the case of a 57-year-old female patient with cardiac lymphangioma from atrial septum. Read More

Case Rep Surg 2018 5;2018:4368131. Epub 2018 Dec 5.

Surgical Department, Larnaca General Hospital, Cyprus.

Lymphangiomas are unusual benign malformations, which can often be misdiagnosed due to their relatively mild and nonspecific symptomatology. Their appearance in the anal canal is extremely rare. Correct diagnosis is necessary for formulating appropriate management. Read More

Int J Surg Pathol 2019 Jan 8:1066896918823072. Epub 2019 Jan 8.

1 NTT Medical Center Tokyo, Tokyo, Japan.

Korean J Intern Med 2019 Jan 7. Epub 2019 Jan 7.

Department of Pathology, Sakarya University Research and Educational Hospital, Sakarya, Turkey.

Medicine (Baltimore) 2019 Jan;98(1):e14009

Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu.

Rationale: Lymphangiomatous polyps of the palatine tonsils are benign tumors that are rare in both adults and children. Most patients suffering from this disease present with nonspecific symptoms similar to those of chronic tonsillitis.

Patient Concern: We report a case of a 21-year-old male miner who presented with a chronic history of a foreign body sensation in the oropharynx and an intermittently sore throat. Read More

Ann R Coll Surg Engl 2019 Jan 3:e1-e4. Epub 2019 Jan 3.

Department of General Surgery, King Fahd Central Hospital , Jazan , Saudi Arabia.

Cystic hygroma is a benign congenital malformation of the lymphatic system that occurs in children younger than two years of age. Hygroma commonly presents in head and neck but can be present anywhere. It is rarely seen in adults. Read More

World J Gastrointest Oncol 2018 Dec;10(12):522-527

Department of Gastroenterology, Northern Jiangsu Province People's Hospital, Yangzhou 225001, Jiangsu Province, China.

Background: Mesenteric lymphangioma (ML) in adults is a very rare disease. We report six hospitalized adult patients with ML in our hospital between January 2013 and July 2018 to investigate the characteristics and prognosis of ML in adults.

Case Summary: The male-to-female ratio was 3:3, and the median age at diagnosis was 55. Read More

PLoS Biol 2018 Dec 28;16(12):e2005907. Epub 2018 Dec 28.

Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

Metastatic dissemination employs both the blood and lymphatic vascular systems. Solid tumors dynamically remodel and generate both vessel types during cancer progression. Lymphatic vessel invasion and cancer cells in the tumor-draining lymph nodes (LNs) are prognostic markers for breast cancer metastasis and patient outcome, and tumor-induced lymphangiogenesis likely influences metastasis. Read More

Pediatr Neurol 2019 Feb 22;91:65-67. Epub 2018 Nov 22.

Department of Pediatrics, Severance Children's Hospital, College of Medicine, Yonsei University, Seoul, South Korea. Electronic address:

Int J Pediatr Otorhinolaryngol 2019 Mar 7;118:21-24. Epub 2018 Dec 7.

Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, United States.

Objective: Identify adverse events associated with surgical management of head and neck lymphatic malformations in children by investigating a US national database.

Data Source: Pediatric American College of Surgeons (ACS) National Surgical Quality Improvement Program (ACS NSQIP - pediatric), years 2012-2016.

Methods: Subjects included children under 18 years with a postoperative diagnosis of International Classification of Diseases (ICD), 9 th revision code: 228. Read More

Skinmed 2018 21;16(6):411-413. Epub 2018 Dec 21.

DermatoVenereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati-Delhi, India.

Khirurgiia (Mosk) 2018 (12):132-135

Herzen Moscow Scientific Oncological Institute - the branch of the National Medical Research Center for Radiology of Healthcare Ministry of the Russia, Moscow, Russia.

Lymphatic malformation (LM) is a benign neoplasm that consists of abnormally formed lymphatic vessels and cavities. The incidence of LM is 6% among all benign tumors. Mediastinal localization is extremely rare, only case reports in adults are described. Read More

Ear Nose Throat J 2018 Dec;97(12):389-390

Department of ENT and Head and Neck Surgery, Maulana Azad Medical College, New Delhi, India.

J Dtsch Dermatol Ges 2019 Feb 3;17(2):192-194. Epub 2018 Dec 3.

Servicio de Dermatología, Hospital de Cabueñes, Gijón, Asturias, Spain.

Gland Surg 2018 Oct;7(5):487-492

Department of Human Pathology of the Adult and Evolutive Age "Gaetano Barresi", Section of General Surgery, University of Messina, Messina, Italy.

Lymphangiomas are rare congenital benign tumors arising from the lymphatic system. The incidence of this disease in the pancreas is extremely rare, accounting for less than 1% of these tumors. Before introducing the review we reported a case of a 67-year-old woman with cystic lymphangioma of the pancreas. Read More

J Surg Res 2019 Jan 4;233:256-261. Epub 2018 Sep 4.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, Colorado; Division of Pediatric Surgery, Children's Hospital Colorado, Vascular Anomalies Center, Aurora, Colorado; Division of Pediatrics, University of Colorado, School of Medicine, Aurora, Colorado.

Background: Lymphatic malformations (LMs) are congenital and arise from errors in vascular embryogenesis. LMs are categorized by cyst size as microcystic, macrocystic, or combined. Abdominal LMs are rare. Read More

Vasc Endovascular Surg 2018 Nov 29:1538574418814057. Epub 2018 Nov 29.

4 ENT Clinic of Red Cross Hospital, Athens, Greece.

Lymphangiomas are rare benign malformations of the lymphatic system, commonly present in children, over the head and neck area. Occasionally, they can grow significantly in size and especially those located over the cervical region can cause airway obstruction and become life-threatening. Recurrent lymphangiomas usually occur during the early postsurgical period and 80% of them within the first 3 to 5 years. Read More

Turk J Urol 2018 Sep 1;44(5):437-440. Epub 2018 Sep 1.

Department of General Surgery, Post Graduate Institute of Medical Education And Research (PGIMER), Chandigarh, India.

We present a 15 year old boy with multiple vesicular lesions involving the scrotum and penile skin which developed following circumcision. Surgical excision of the penoscrotal skin with local flap cover was done. Histopathology was consistent with lymphangioma circumscriptum. Read More

Eur J Obstet Gynecol Reprod Biol 2018 Dec 15;231:274-279. Epub 2018 Oct 15.

Department of Ultrasound, GZ Women & Children Medical Centre, China.

Objective: To investigate the treatment and prognosis of fetal lymphangioma and factors that inform treatment selection.

Study Design: Retrospective analysis of 79 patients with fetal lymphangioma treated at our hospital. Treatment methods included medical termination (death in-utero), expectant treatment, surgery, and interventional sclerotherapy (including ex utero intrapartum treatment, EXIT). Read More

Asian J Neurosurg 2018 Oct-Dec;13(4):1292-1294

Department of Pathology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

We report a case of biopsy-proven retrobulbar lymphangioma in a 14-year-old girl. She presented with chief complaints of swelling in the left eye for 2 months. The patient underwent imaging evaluation and it was diagnosed as cavernous hemangioma, radiologically. Read More

Pneumologie 2018 Dec 19;72(12):851-854. Epub 2018 Nov 19.

Thoraxchirurgische Abteilung des LungenZentrums Saar, SHG-Kliniken, Völklingen.

An 82-year-old male patient presented with a left-sided spontaneous chylothorax. A computed tomographic scan of the chest revealed a cystic tumor in the right upper anterior mediastinum and nodules in the left mediastinum that we interpreted as enlarged lymph nodes. On suspicion of lymphoma and for therapy of chylothorax, we performed a left-sided thoracotomy. Read More

Int J Surg Case Rep 2018 8;53:246-249. Epub 2018 Oct 8.

Cardiothoracic Surgery Department, Santa Maria Hospital, Lisbon, Portugal.

Introduction: Tumors of the heart are uncommon, and lymphangiomas are among the rarest of this group, with very few cases reported. These tumors consist of a benign slow-flow vascular malformation.

Presentation Of Case: We report a case of a man diagnosed incidentally with a pericardial mass and our surgical approach for its treatment. Read More

Medicine (Baltimore) 2018 Nov;97(45):e12946

Department of Radioloy, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.

Rationale: Lymphangiomas develop in the head, neck, and axilla of patients <2 years old in more than 90% of cases. They are rarely reported in adults.

Patient Concerns: Here, we report on a 37-year-old woman with a firm, hypoechoic 3. Read More

Int J Surg Pathol 2018 Oct 31:1066896918810428. Epub 2018 Oct 31.

1 Hartford Hospital, Hartford, CT, USA.

J Comput Assist Tomogr 2018 Oct 26. Epub 2018 Oct 26.

Department of Radiology, Thomas Jefferson University School of Medicine, Philadelphia, PA.

We report a case of a 29-year-old woman with a pancreatic lymphangioma who presented clinically as a case of acute pancreatitis. Lymphangiomas are benign tumors of vascular origin with lymphatic differentiation, most commonly found in the head and neck. Pancreatic lymphangiomas are extremely rare, accounting for only 1% of abdominal lymphangiomas, with approximately 60 cases reported in the literature. Read More

Zhonghua Fu Chan Ke Za Zhi 2018 Oct;53(10):665-670

Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

To analyze prognosis-related risk factors of first trimester cystic hygroma (CH) fetuses in which nuchal translucency (NT) was found to be thickened. Tolly 216 singleton pregnancies in which fetal NT≥3.0 mm at the 11~13 weeks scan accepted invasive prenatal diagnosis in Beijing Gynecology and Obstetrics Hospital, Capital Medical University, from January 2014 to December 2015 were collected. Read More

Int J Surg Case Rep 2018 4;53:50-53. Epub 2018 Oct 4.

Services Hospital, Lahore, Pakistan.

Introduction: Lipoblastoma usually develops in extremities and trunk during infancy or childhood. Its occurrence in head and neck is rare.

Case Presentation: Here we present a case of lipoblastoma in 14 years old female who developed swelling in the nape of her neck. Read More

Eur J Obstet Gynecol Reprod Biol 2018 Dec 9;231:268-273. Epub 2018 Oct 9.

Department of Ultrasound, GZ Women & Children Medical Centre, China.

Objective: To investigate the characteristics of fetal lymphangioma, including their location, imaging features, prenatal and differential diagnoses, treatment, and prognosis.

Study Design: Imaging data of 79 patients with fetal lymphangioma treated at our hospital were obtained. Imaging modalities included prenatal and post-natal magnetic resonance imaging (MRI), prenatal and post-natal color Doppler ultrasound, and post-natal contrast-enhanced computed tomography (CT). Read More

Taiwan J Obstet Gynecol 2018 Oct;57(5):763-764

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Department of Bioengineering, Tatung University, Taipei, Taiwan.

Photodiagnosis Photodyn Ther 2018 Oct 16. Epub 2018 Oct 16.

Medical School of University Nove de Julho, Brazil. Electronic address:

The aim of this case report was to evaluate the treatment of vulvar lymphangioma applying photodynamic therapy (PDT). Patient aged 61 years old complained of burning, local pain, which caused intense discomfort for over 5 years. She had developed vulvar edema, papules and vesicles that draining clear exudate, in which histological finding confirmed the vulvar lymphangioma. Read More

Ocul Oncol Pathol 2018 Sep 23;4(2):82-89. Epub 2017 Aug 23.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA, USA.

Objective: To distinguish between a multifocal orbital lymphoid tumor and a major simulator represented by a diffuse lymphaticovenous malformation.

Methods: We performed a comparison of clinical and radiographic (magnetic resonance imaging [MRI]) findings of these two disparate entities and demonstrated how a misdiagnosis can be prevented.

Results: Orbital lymphoid tumors develop in adults at around 60 years of age, whereas extensive lymphaticovenous malformations are generally detected in the first decade. Read More

J Pediatr 2019 Feb 11;205:288-288.e1. Epub 2018 Oct 11.

Womens and Perinatal Services Leicester Royal Infirmary University Hospitals of Leicester Leicester, United Kingdom.

Medicine (Baltimore) 2018 Oct;97(41):e12599

Taizhou People's Hospital, Taizhou, Jiangsu, China.

Rationale: Hemolymphangioma of the pancreas is an extremely rare benign tumor; only 10 patients with this disease have been reported to date, the majority of whom were women.

Patient Concerns: We describe a 28-year-old man who presented with abdominal pain and discomfort. Computed tomography and magnetic resonance imaging data showed a huge heterogeneous solid cystic mass at the retroperitoneal pancreatic head. Read More

Quant Imaging Med Surg 2018 Sep;8(8):853-875

Department of Radiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.

Besides ultrasound and nuclear medicine techniques, computed tomography (CT) and magnetic resonance imaging (MRI) are commonly used to examine adrenal lesions in both symptomatic and asymptomatic patients. Some adrenal lesions have characteristic radiological features. If an adrenal nodule is discovered incidentally, determining whether the lesion is benign or malignant is of great importance. Read More

Urol Case Rep 2019 Jan 28;22:6-7. Epub 2018 Sep 28.

Department of Urology, La Rabta Hospital, Tunis, Tunisia.

BMJ Case Rep 2018 Oct 7;2018. Epub 2018 Oct 7.

Department of Surgery, Duke University Hospital, Durham, North Carolina, USA.

Lymphangiomas are most commonly described as a small painless mass in the neck or a vesicular rash in an infant patient. Ninety per cent of cases are diagnosed before the age of 2. Treatment usually involves surgical resection. Read More

Medicine (Baltimore) 2018 Oct;97(40):e12552

Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital.

Rational: Lymphangiomatosis is rare and benign, and slowly proliferating lymphatic vessels of unknown etiology and visceral lymphangiomatosis involving the spleen is rare. Since lymphangiomatosis may be asymptomatic or present as a sense of fullness, splenic cystic lymphangiomatosis is a disease of little concern.

Patient Concerns: A 34-year-old woman suffering from progressive epigastric fullness after oral intake for two weeks. Read More

J Vasc Interv Radiol 2018 Oct;29(10):1438-1439

Division of Vascular and Interventional Radiology, Department of Radiology, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109. Electronic address: