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Clin Case Rep 2019 Apr 17;7(4):612-615. Epub 2019 Feb 17.

Dermatology Service of Clinics Hospital of Uberlandia (HCU/UFU) Federal University of Uberlandia (UFU) Uberlândia Brazil.

Cutaneous lymphangioma circumscriptum (CLC) is a rare congenital malformation of the superficial cutaneous lymphatic ducts. Case report: A 7-year-old boy presented plaque with grouped vesicles resembling a "frog spawn" on the upper left thigh, since 4 months old. The clinical, dermatoscopic and histopathological correlation is of great importance. Read More

Ann Med Surg (Lond) 2019 May 29;41:6-10. Epub 2019 Mar 29.

Department of Surgery, University of L'Aquila, Italy.

Lymphangiomatosis is a benign proliferation of lymph vessels. Lymphatic diseases can vary from small lymphangioma to generalized lymphangiomatosis, which is a rare condition and can have several clinical manifestations. The gastrointestinal tract may be affected, but the incidence in the intestinal wall is very low. Read More

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, Farhat Hached University Hospital, Sousse, Tunisia.

Lymphatic malformations (LMs) of the tongue are usually associated with macroglossia, raising the twin problems of a functional impairment and life-threatening complications. Oral sirolimus has recently proved to be effective in vascular malformations. We report a case of extensive LM of the tongue, successfully treated with sirolimus. Read More

Breast J 2019 Apr 10. Epub 2019 Apr 10.

Department of Radiology, Complexo Hospitalario Universitario A Coruña, La Coruña, Spain.

Clin J Gastroenterol 2019 Apr 10. Epub 2019 Apr 10.

Department B of Surgery, Charles Nicolle Hospital, Tunis, Tunisia.

Retaining the etiology of a cystic lesion in the right iliac fossa can be difficult. Appendicular hydatid cyst is a very uncommon cause of a such lesion. In some cases, diagnosis is not obvious. Read More

Autops Case Rep 2019 Apr-Jun;9(2):e20180780. Epub 2019 Mar 22.

Miguel Servet University Hospital, Department of Pathology. Zaragoza, Spain.

Hydatidosis is a frequent infestation in large endemic areas, caused by helminths. Primary localization within the muscle or bone tissues is rare. We report the case of a 52-year-old woman with a cystic lesion located in the right pectoralis minor muscle, who was initially diagnosed with cystic lymphangioma by imaging examination. Read More

Cir Esp 2019 Apr 1. Epub 2019 Apr 1.

Unidad de Cirugía Hepatobiliar y Pancreática, Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario de Valme, Sevilla, España.

Iran J Med Sci 2019 Mar;44(2):172-175

Department of Pathology, Gerash Hospital, Gerash University of Medical Sciences, Gerash, Iran.

Lymphangiomas are benign lesions consisting of abnormal proliferations of lymphatic vessels. Lymphangiomas associated with bone involvement, particularly in vertebral bodies, accompanied by cord compression, are extremely rare, and our literature review yielded only a few relevant reports. We describe a 61-year-old man presenting with progressive paraparesis and sphincter disturbance of 5 months' duration. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Mar 18;236:139-142. Epub 2019 Mar 18.

Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy; Diagnosi Ecografica e Prenatale di A.Di Meglio, Naples, Italy.

Fetal lymphangioma is a rare congenital malformation of lymphatic system that involve the skin and the subcutaneous tissue. The vast majority of the lymphangioma occurs in the neck. More rarely lymphangiomas may occur in the axillary region, including chest wall. Read More

Dermatol Surg 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, University of California, Irvine, Irvine, California.

Background: The need for noninvasive methods in treatment of cutaneous disease has continued to evolve exponentially. Amidst the search for technologies, radiofrequency (RF) has proven efficacious in numerous skin disease processes. Although RF is well known for its cosmetic utility, its mechanism is valued in the treatment of many noncosmetic cutaneous conditions of various etiologies. Read More

Case Rep Orthop 2019 11;2019:8762614. Epub 2019 Feb 11.

Department of Orthopaedic Surgery and Traumatology, Clemenceau Medical Center Affiliated with Johns Hopkins International, Clemenceau, Beirut, Lebanon.

Cystic lymphangiomas are benign tumors originating mainly in the head and neck of the pediatric population. The authors report a rare case of cystic lymphangioma in the right elbow of an 8-month-old baby treated successfully by complete surgical resection. Read More

Pathol Res Pract 2019 Mar 6. Epub 2019 Mar 6.

Department of Pathology, Medical University of Warsaw, ul. Pawińskiego 7, 02-142, Warsaw, Poland.

Published data regarding lymphangiomatous cysts of the adrenal glands (also known as adrenal cystic lymphangiomas) are limited to case reports and a few small case series. We analyzed the clinicopathologic features and histomorphologic spectrum of 37 cases of adrenal cystic lymphangiomatous lesions. There were 26 females and 11 males ranging from 12 to 67 years old (median, 34 years). Read More

J Laryngol Otol 2019 Mar 1;133(3):256-259. Epub 2019 Mar 1.

Department of Otorhinolaryngology,Brighton and Sussex University Hospitals Trust,Brighton,UK.

Background: Deep neck space abscesses are an uncommon but life-threatening emergency presentation to the ENT surgeon because of potential acute airway compromise.

Objective: This paper presents a novel case of a palatine tonsillar, low-flow, lymphovenous malformation pre-disposing to multifocal deep neck space collections and resultant acute airway compromise. Read More

J Craniofac Surg 2019 Feb 21. Epub 2019 Feb 21.

University of Health Sciences Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey.

Cervical lymphangiomas are benign congenital malformations of lymphatic system usually seen in children under 2 years of age. It is rare in adults. They can be seen in any part of the body but the most common area in the neck region is posterior triangle. Read More

Australas J Dermatol 2019 Feb 27. Epub 2019 Feb 27.

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Lymphangioma circumscriptum is a benign hamartomatous malformation involving the lymphatic system of skin and subcutaneous tissue. It can involve any part of the body with maximum predilection for proximal parts of limbs. Vulvar involvement is quite infrequent. Read More

Dermatol Surg 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, South Korea.

J Surg Case Rep 2019 Feb 12;2019(2):rjz027. Epub 2019 Feb 12.

Department of Surgery, Mercy Hospital and Medical Center, Chicago, IL, USA.

Adult cystic lymphangiomas are exceedingly rare tumors resulting from malformation of the lymphatic vessels. Like their pediatric counterparts, these lesions almost exclusively involve the head and neck. However, adult cystic lymphangiomas have been reported in several organs. Read More

Surg Today 2019 May 18;49(5):410-419. Epub 2019 Feb 18.

Department of Pediatric Surgery, Osaka Women's and Children's Hospital, 840, Murodocho, Izumi, Osaka, Japan.

Purpose: Airway obstruction caused by lymphatic malformation (LM) in the head and neck may require a tracheostomy. We present the results of our analysis of a nationwide survey on the indications for tracheostomy in children with head and neck LM.

Methods: We analyzed data in relation to tracheostomy based on a questionnaire about 518 children with head and neck LM without mediastinal involvement. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):141-142

Department of Otorhinolaryngology, Second Hospital of Dalian Medical University, Dalian 116027, China.

J Craniomaxillofac Surg 2018 Sep 20. Epub 2018 Sep 20.

University of Parma, Department of Maxillo Facial Surgery (Head: Prof. Enrico Sesenna), Italy.

Vascular malformations are often found inside the orbit. Isolated venous malformations (frequently misnamed as cavernous hemangiomas) are the most frequent among these. However, also lymphatic and arteriovenous malformations can affect the orbit. Read More

J Am Acad Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Pediatric Surgery, the Second Affiliated Hospital, Xi'an JiaoTong University, Xi'an 710004, China. Electronic address:

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Breast and Medical Oncology, National Cancer Center Hospital, Japan.

Objective Few reports have analyzed the diagnostic process of carcinoma of unknown primary site (CUP) or have focused on the frequency of nonmalignant lesions among patients with suspected malignant diseases. The aim of this study was to investigate the incidence and characteristics of nonmalignant diseases that tend to be mistaken for malignant diseases. Patients We retrospectively analyzed the medical records of patients with suspected CUP who were referred to the National Cancer Center Hospital (Tokyo, Japan) between April 2007 and December 2014. Read More

Basic Clin Androl 2019 28;29. Epub 2019 Jan 28.

3Department of Vattikuti Urology Institute, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 USA.

Background: Penile lymphangiomas are rare manifestations of lymphangiomas or lymphatic malformations which are more commonly found in the head or neck region of the body. Lymphangiomas are further categorized as lymphangioma circumscriptum, cavernous lymphangioma, cystic hygroma, or acquired lymphangiomas (also known as lymphangiectasia), based on their depth and etiology.

Results: A literature review revealed only 30 cases of penile lymphangioma between 1947 and March 30, 2018. Read More

J Surg Case Rep 2019 Jan 24;2019(1):rjy334. Epub 2019 Jan 24.

Department of General Surgery, Presence Saint Joseph Hospital, Chicago, IL, USA.

The etiology of pneumatosis cystoides intestinalis (PCI) is multifactorial and its corresponding treatment is similarly complex. One causation of PCI, is lymphatic disruption. This association is discussed in this case report involving an incident of abdominal lymphangioma and subsequent development of PCI in a 57-year-old female. Read More

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Naja Clinic, Department of Dermatology, Gilan, Rasht.

Lymphangioma circumscriptum is a developmental anomaly of lymphatic vessels, which appear as aggregates of clear or hemorrhagic vesicles on the skin or mouth. Glans penis involvement is very uncommon. Because of the sensitivity of the area, possible functional, cosmetic, or psychologic disturbances can result. Read More

Dermatol Online J 2018 10 15;24(10). Epub 2018 Oct 15.

Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

Cutaneous mucinosis of infancy (CMI) is a rare dermatologic condition, first reported in 1980 and currently classified within the complex group of papular mucinoses. We report a case of CMI and review the prior 13 cases in the literature. The patient was a 5-year-old girl who presented with asymptomatic dermal papules and plaques on her leg and back with no overlying color change. Read More

Plast Reconstr Surg Glob Open 2018 Dec 13;6(12):e2059. Epub 2018 Dec 13.

Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo, Japan.

Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. We report a child who was initially diagnosed with lymphangioma and referred to our institute for sclerotherapy, only to find out that the tumor was in fact MASC after excision. This case of MASC is in a 7-year-old boy, the youngest case so far reported. Read More

Pediatrics 2019 Feb 17;143(2). Epub 2019 Jan 17.

St Louis Children's Hospital, St Louis, Missouri.

Methemoglobinemia occurs when the heme moiety of hemoglobin (Hb) is oxidized from the ferrous to ferric state, leading to impairments in oxygen transport and delivery. Methemoglobinemia is rare in pediatric patients but has been described in the setting of congenital abnormalities in the Hb structure, inherited enzyme deficiencies, oxidative Hb injury in response to illness, and oxidative Hb injury due to toxicants. We present a 1-week-old infant born with a cervical lymphangioma who developed persistent desaturations that were unresponsive to oxygen after sclerotherapy with doxycycline. Read More

J Surg Case Rep 2019 Jan 11;2019(1):rjy336. Epub 2019 Jan 11.

Department of Colorectal Surgery, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Background: Cystic lymphangiomas are rare benign tumours and their actual incidence in the colon is unclear. Within the large bowel, these lesions are often submucosal and are incidental findings on colonoscopy.

Case Report: A 43-year-old man with colonic lymphangioma presented with a 7-month history of abdominal pain and altered bowel habits. Read More

Medicine (Baltimore) 2019 Jan;98(2):e14000

Department of Cardiac Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, People's Republic of China.

Rationale: Cardiac lymphangioma is a rare disease. Until now, there have been only a few cases of cardiac lymphangioma reported in the literature.

Patient Concerns: We report the case of a 57-year-old female patient with cardiac lymphangioma from atrial septum. Read More

Case Rep Surg 2018 5;2018:4368131. Epub 2018 Dec 5.

Surgical Department, Larnaca General Hospital, Cyprus.

Lymphangiomas are unusual benign malformations, which can often be misdiagnosed due to their relatively mild and nonspecific symptomatology. Their appearance in the anal canal is extremely rare. Correct diagnosis is necessary for formulating appropriate management. Read More

Int J Surg Pathol 2019 Jan 8:1066896918823072. Epub 2019 Jan 8.

1 NTT Medical Center Tokyo, Tokyo, Japan.

Korean J Intern Med 2019 Jan 7. Epub 2019 Jan 7.

Department of Pathology, Sakarya University Research and Educational Hospital, Sakarya, Turkey.

Medicine (Baltimore) 2019 Jan;98(1):e14009

Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu.

Rationale: Lymphangiomatous polyps of the palatine tonsils are benign tumors that are rare in both adults and children. Most patients suffering from this disease present with nonspecific symptoms similar to those of chronic tonsillitis.

Patient Concern: We report a case of a 21-year-old male miner who presented with a chronic history of a foreign body sensation in the oropharynx and an intermittently sore throat. Read More

Ann R Coll Surg Engl 2019 Mar 3;101(3):e84-e87. Epub 2019 Jan 3.

Department of General Surgery, King Fahd Central Hospital , Jazan , Saudi Arabia.

Cystic hygroma is a benign congenital malformation of the lymphatic system that occurs in children younger than two years of age. Hygroma commonly presents in head and neck but can be present anywhere. It is rarely seen in adults. Read More

World J Gastrointest Oncol 2018 Dec;10(12):522-527

Department of Gastroenterology, Northern Jiangsu Province People's Hospital, Yangzhou 225001, Jiangsu Province, China.

Background: Mesenteric lymphangioma (ML) in adults is a very rare disease. We report six hospitalized adult patients with ML in our hospital between January 2013 and July 2018 to investigate the characteristics and prognosis of ML in adults.

Case Summary: The male-to-female ratio was 3:3, and the median age at diagnosis was 55. Read More

PLoS Biol 2018 Dec 28;16(12):e2005907. Epub 2018 Dec 28.

Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

Metastatic dissemination employs both the blood and lymphatic vascular systems. Solid tumors dynamically remodel and generate both vessel types during cancer progression. Lymphatic vessel invasion and cancer cells in the tumor-draining lymph nodes (LNs) are prognostic markers for breast cancer metastasis and patient outcome, and tumor-induced lymphangiogenesis likely influences metastasis. Read More

Pediatr Neurol 2019 Feb 22;91:65-67. Epub 2018 Nov 22.

Department of Pediatrics, Severance Children's Hospital, College of Medicine, Yonsei University, Seoul, South Korea. Electronic address:

Int J Pediatr Otorhinolaryngol 2019 Mar 7;118:21-24. Epub 2018 Dec 7.

Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, United States.

Objective: Identify adverse events associated with surgical management of head and neck lymphatic malformations in children by investigating a US national database.

Data Source: Pediatric American College of Surgeons (ACS) National Surgical Quality Improvement Program (ACS NSQIP - pediatric), years 2012-2016.

Methods: Subjects included children under 18 years with a postoperative diagnosis of International Classification of Diseases (ICD), 9 th revision code: 228. Read More

Skinmed 2018 21;16(6):411-413. Epub 2018 Dec 21.

DermatoVenereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati-Delhi, India.

Khirurgiia (Mosk) 2018(12):132-135

Herzen Moscow Scientific Oncological Institute - the branch of the National Medical Research Center for Radiology of Healthcare Ministry of the Russia, Moscow, Russia.

Lymphatic malformation (LM) is a benign neoplasm that consists of abnormally formed lymphatic vessels and cavities. The incidence of LM is 6% among all benign tumors. Mediastinal localization is extremely rare, only case reports in adults are described. Read More

Ear Nose Throat J 2018 Dec;97(12):389-390

Department of ENT and Head and Neck Surgery, Maulana Azad Medical College, New Delhi, India.

J Dtsch Dermatol Ges 2019 02 3;17(2):192-194. Epub 2018 Dec 3.

Servicio de Dermatología, Hospital de Cabueñes, Gijón, Asturias, Spain.

Gland Surg 2018 Oct;7(5):487-492

Department of Human Pathology of the Adult and Evolutive Age "Gaetano Barresi", Section of General Surgery, University of Messina, Messina, Italy.

Lymphangiomas are rare congenital benign tumors arising from the lymphatic system. The incidence of this disease in the pancreas is extremely rare, accounting for less than 1% of these tumors. Before introducing the review we reported a case of a 67-year-old woman with cystic lymphangioma of the pancreas. Read More

J Surg Res 2019 Jan 4;233:256-261. Epub 2018 Sep 4.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, Colorado; Division of Pediatric Surgery, Children's Hospital Colorado, Vascular Anomalies Center, Aurora, Colorado; Division of Pediatrics, University of Colorado, School of Medicine, Aurora, Colorado.

Background: Lymphatic malformations (LMs) are congenital and arise from errors in vascular embryogenesis. LMs are categorized by cyst size as microcystic, macrocystic, or combined. Abdominal LMs are rare. Read More

Vasc Endovascular Surg 2019 Feb 29;53(2):170-176. Epub 2018 Nov 29.

4 ENT Clinic of Red Cross Hospital, Athens, Greece.

Lymphangiomas are rare benign malformations of the lymphatic system, commonly present in children, over the head and neck area. Occasionally, they can grow significantly in size and especially those located over the cervical region can cause airway obstruction and become life-threatening. Recurrent lymphangiomas usually occur during the early postsurgical period and 80% of them within the first 3 to 5 years. Read More

Turk J Urol 2018 Sep 1;44(5):437-440. Epub 2018 Sep 1.

Department of General Surgery, Post Graduate Institute of Medical Education And Research (PGIMER), Chandigarh, India.

We present a 15 year old boy with multiple vesicular lesions involving the scrotum and penile skin which developed following circumcision. Surgical excision of the penoscrotal skin with local flap cover was done. Histopathology was consistent with lymphangioma circumscriptum. Read More

Eur J Obstet Gynecol Reprod Biol 2018 Dec 15;231:274-279. Epub 2018 Oct 15.

Department of Ultrasound, GZ Women & Children Medical Centre, China.

Objective: To investigate the treatment and prognosis of fetal lymphangioma and factors that inform treatment selection.

Study Design: Retrospective analysis of 79 patients with fetal lymphangioma treated at our hospital. Treatment methods included medical termination (death in-utero), expectant treatment, surgery, and interventional sclerotherapy (including ex utero intrapartum treatment, EXIT). Read More

Asian J Neurosurg 2018 Oct-Dec;13(4):1292-1294

Department of Pathology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

We report a case of biopsy-proven retrobulbar lymphangioma in a 14-year-old girl. She presented with chief complaints of swelling in the left eye for 2 months. The patient underwent imaging evaluation and it was diagnosed as cavernous hemangioma, radiologically. Read More

Pneumologie 2018 Dec 19;72(12):851-854. Epub 2018 Nov 19.

Thoraxchirurgische Abteilung des LungenZentrums Saar, SHG-Kliniken, Völklingen.

An 82-year-old male patient presented with a left-sided spontaneous chylothorax. A computed tomographic scan of the chest revealed a cystic tumor in the right upper anterior mediastinum and nodules in the left mediastinum that we interpreted as enlarged lymph nodes. On suspicion of lymphoma and for therapy of chylothorax, we performed a left-sided thoracotomy. Read More