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J Urol 2020 Jun 26:101097JU0000000000001178. Epub 2020 Jun 26.

Colorectal Dis 2020 Jun 24. Epub 2020 Jun 24.

Department of General Surgery, ASUGI, Trieste, Italy.

We present the case of a 24-year-old male who underwent a laparoscopic left retroperitoneal lymph node dissection for lymph node metastasis detected at the staging CT-scan after a radical left orchifuniculectomy for a non seminomatous testicular tumor (pT2, Stage IIB). The procedure started by obtaining exposure of the left retroperitoneal space by left colon mobilization. The dissection was carried out from the iliac bifurcation to the left renal vein, highlighting the anatomical landmarks of this procedure: iliac bifurcation, aortic plane, left ureter, left renal and gonadal vein. Read More

J Robot Surg 2020 Jun 22. Epub 2020 Jun 22.

The James Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

The objectives were to evaluate the safety and oncologic efficacy of primary robotic retroperitoneal lymph node (R-RPLND) dissection for testicular germ cell tumors. A retrospective analysis was performed on all primary R-RPLND cases performed by a single surgeon, who performs both open and R-RPLND at a high-volume academic institution, between August 2013 and August 2019. Data on patient demographics, operative techniques, perioperative outcomes, and tumor characteristics were obtained. Read More

Aktuelle Urol 2020 Jun 17. Epub 2020 Jun 17.

Uniklinik Köln, Urologie, Köln.

J Gastrointest Surg 2020 Jun 17. Epub 2020 Jun 17.

Department of Surgery, St Elizabeth's Medical Center, Tufts University School of Medicine, 11 Nevins St., Suite 201, Boston, MA, 02135, USA.

Background: Radical Antegrade Modular Pancreatosplenectomy (RAMPS) minimizes the risk of a positive retroperitoneal margin and maximizes lymph node harvest in distal pancreatic cancers.1-7 In those with celiac trunk involvement, resection of the celiac trunk (modified Appleby procedure) is a surgical option in which postoperative liver perfusion relies on blood flow via superior mesenteric artery (SMA) and gastroduodenal artery (GDA).8, 9 PATIENT: A 66-year-old male was diagnosed with a 3. Read More

Indian J Urol 2020 Apr-Jun;36(2):112-116. Epub 2020 Apr 7.

Department of Surgical Oncology, Apollo Specialty Hospital, Chennai, Tamil Nadu, India.

Introduction: Postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) and metastasectomy play an important role in the management of advanced-stage nonseminomatous germ cell tumors (NSGCT). We aimed to analyze preoperative parameters that could predict postoperative histology.

Materials And Methods: We analyzed the data of 72 patients who underwent PC-RPLND and 14 patients who underwent metastasectomy after receiving cisplatin- or carboplatin-based chemotherapy for advanced stage NSGCT at our institute from 1994 to 2015. Read More

Ann R Coll Surg Engl 2020 Jun 15:e1-e4. Epub 2020 Jun 15.

Department of Gastroenterological Surgery, Saitama Cancer Center, Saitama, Japan.

Colorectal cancer metastasis to the retroperitoneum, especially solitary metastasis allowing curative resection, is rare. We report a case of complete resection of retroperitoneal metachronous solitary metastasis from caecal cancer without distant metastasis. An 80-year-old woman with caecal cancer underwent laparoscopic ileocaecal resection with regional lymph node dissection. Read More

Chin Clin Oncol 2020 Jun 3. Epub 2020 Jun 3.

Surgical Oncology, Gynecologic Tumors Division, Instituto Nacional de Cancerología, Mexico City, Mexico.

The indication of systematic lymphadenectomy in advanced ovarian cancer without apparent macroscopic lymph node involvement has been controversial over the past three decades, and the recommendation to perform it or not has been based on multiple retrospective studies, small cohort studies, and few randomized studies with several biases; however, it seems that this controversy has come to an end after the recent publication of a randomized clinical trial. The study of lymph node disease in ovarian cancer has intensified in the last two decades, so far that it was part of the changes of the last update of the International Federation of Gynecology and Obstetrics (FIGO) staging; In this review, a search was made of the available literature to understand the evolution of knowledge about the implications of the realization or not of lymphadenectomy in two scenarios of advanced ovarian cancer (namely, the presence or not of lymph node disease macroscopic), without losing the landscape of the importance of peritoneal disease in these stages, which, as we will see throughout the review, the complete cytoreduction of the tumor remains an integral part of the treatment, since residual disease is one of the most relevant prognostic factors. Nowadays, we can confidently state that systematic lymphadenectomy in patients with advanced ovarian cancer without clinically apparent nodal disease is not necessary, and the presence of macroscopic retroperitoneal lymph node disease should be resected as part of cytoreductive surgery since it will be this and the residual disease that determine the prognosis of the patients. Read More

Int J Cancer 2020 Jun 11. Epub 2020 Jun 11.

Department of Surgery, East Carolina University, Greenville, North Carolina.

Paratesticular rhabdomyosarcoma (PT-RMS) carries a favorable prognosis, but questions persist regarding optimal management. Our goal was to determine the importance of primary tumor resection and surgical assessment of retroperitoneal lymph nodes during staging in patients with PT-RMS. We analyzed patients with localized PT-RMS enrolled onto one of four Children's Oncology Group studies (D9602, ARST0331, D9803 or ARST0531). Read More

Rev Urol 2020 ;22(1):40-42

Department of Urology, NYU Langone Health, Department of Population Health, NYU Grossman School of Medicine New York, NY.

Urology 2020 Jun 4. Epub 2020 Jun 4.

Department of Urology, Japanese Red Cross Wakayama Medical Center, 4-20, Komatsubara-dori, Wakayama City, Wakayama, Japan.

Background: Laparoscopic retroperitoneal lymph node dissection (RPLND) in metastatic testicular cancer is a technically challenging procedure. In right-modified RPLND, retrocaval lymph nodes are often not visible and cannot be adequately dissected using only the transperitoneal approach. In laparoscopic nephrectomy (LN) for horseshoe kidney, the kidney cannot be sufficiently moved due to its connection to the contralateral kidney, and the isthmus and lower poles have separate blood supplies arising from the aorta or iliac artery. Read More

Urologia 2020 May 27:391560320921714. Epub 2020 May 27.

Department of Urology, University of Turin, Torino, Italy.

Literature: The cancer of testicles represents 1% of male neoplasms and 5% of urological malignant neoplasm. Its incidence has been growing in Western societies. Cancer of testicles usually presents as an increase of consistence in one testicles and absence of pain, as a casual ultrasound scan finding, or it could be highlighted by a scrotal injury. Read More

Urol Oncol 2020 May 21. Epub 2020 May 21.

Indiana University School of Medicine, Indianapolis, IN.

Purpose: Choriocarcinoma germ cell tumors are rare and usually present with significantly elevated human chorionic gonadotropin (hCG) levels. When curable, it is felt to be largely a result of chemotherapy. We sought to determine the histologic characteristics for those undergoing postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) and compare them with metastatic nonseminomatous germ cell tumor (NSGCT) patients with similarly elevated hCG levels. Read More

Transl Androl Urol 2020 Apr;9(2):949-958

Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Open retroperitoneal lymph node dissection (RPLND) is the gold standard for surgical management of the retroperitoneum in patients with testicular cancer, and is associated with excellent oncologic outcomes and significant morbidity including length of stay. Minimally invasive RPLND, starting with laparoscopic retroperitoneal lymph node dissection in 1992 and now robotic retroperitoneal lymph node dissection in 2006, endeavor to decrease the morbidity of open RPLND while maintaining excellent oncologic outcomes. This review surveys the literature regarding both primary and post-chemotherapy robotic RPLND, emphasizing that while early outcomes are promising, much work needs to be done before widespread use of this technique is implemented. Read More

Int Braz J Urol 2020 Jul-Aug;46(4):661-662

Chefe do Departamento de Oncologia Cirúrgica, Beneficência Portuguesa de São Paulo, São Paulo, SP, Brasil.

World J Urol 2020 May 5. Epub 2020 May 5.

Department of Oncological Urology, University Medical Center Utrecht, Utrecht, The Netherlands.

Purpose: To evaluate the perioperative morbidity of PC-RPLND in two intermediate volume centers and to identify predictors of high morbidity.

Methods: Retrospective analysis of 124 patients treated with open PC-RPLND at two tertiary referral centers between 2001 and 2018. Perioperative morbidity was determined by analyzing additional surgical procedures, intra-operative blood loss, and postoperative complications. Read More

J Urol 2020 May 4:101097JU0000000000001121. Epub 2020 May 4.

Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.

Purpose: To investigate the efficacy and analyze the complication risk factors of peritoneovenous shunt (PVS) in treating refractory chylous ascites (CA) following retroperitoneal lymph node dissection (RPLND) in patients with urologic malignancies.

Materials And Methods: From April 2001 to March 2019, all patients with refractory CA after RPLND treated with PVS were reviewed. Demographic characteristics, technical success, efficacy, patency period and complications were studied. Read More

Histopathology 2020 May 1. Epub 2020 May 1.

Department of Pathology, VCU School of Medicine, Richmond, VA, 23226, USA.

Staging of testicular germ cell tumours is essential for treatment planning and prognosis[1]. Lymphovascular invasion (LVI) is one key parameter that establishes pT2 in pathologic staging and Prognostic Stage Group IB for both seminoma and mixed germ cell tumours otherwise limited to the testis [1]. While current practice guidelines [2] consider surveillance preferred for Stage I pure seminomas given the high rate of cure by orchiectomy alone, single agent carboplatin or radiotherapy remain considerations. Read More

Urol Case Rep 2020 Sep 16;32:101207. Epub 2020 Apr 16.

Division of Urology, Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA, USA.

Chylous ascites (CA) is a known complication of retroperitoneal surgery. We are reporting the case of a 65-year-old male who underwent a robotic assisted laparoscopic (RAL) partial nephrectomy for a renal mass and subsequently developed CA. He was successfully treated with a low-fat diet and maintenance of a surgical drain. Read More

J Pediatr Surg 2020 Apr 1. Epub 2020 Apr 1.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN. Electronic address:

Purpose: The aim of this study was to evaluate outcomes based on surgical approach for retroperitoneal lymph node dissection (RPLND) in patients with paratesticular rhabdomyosarcoma (PT-RMS).

Methods: Patients undergoing RPLND for PT-RMS over 10 years at a single institution were retrospectively reviewed. Length of stay (LOS), complications, oral morphine equivalents per kilogram (OME/Kg), lymph node yield, and time to chemotherapy were assessed. Read More

Urol Oncol 2020 Apr 15. Epub 2020 Apr 15.

Section of Urology, University of Chicago Medicine, Chicago, IL.

Introduction: For marker-negative clinical stage (CS) IIA nonseminomatous germ cell tumor (NSGCT), National Comprehensive Cancer Network and American Urological Association guidelines recommend either retroperitoneal lymph node dissection (RPLND) or induction chemotherapy. The goal is cure with one form of therapy. We evaluated national practice patterns in the management of CSIIA NSGCT and utilization of secondary therapies. Read More

Bull Cancer 2020 Jun 14;107(6):666-671. Epub 2020 Apr 14.

Hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, université Paris-Saclay, chirurgie pédiatrique, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France.

Paratesticular Rhabdomyosarcoma accounts for 7 to 11% of pediatric rhabdomyosarcomas. Children older than 10 years have a worse event-free survival (69 to 80% vs. 87 to 92%) than children younger than 10 years. Read More

Int J Gynecol Cancer 2020 Jun 9;30(6):860-864. Epub 2020 Apr 9.

Obstetrics and Gynecology, Tottori University, Yonago, Tottori, Japan.

Introduction: Venous thromboembolism prevention during the perioperative period requires comprehensive risk-level assessment. The aim of this study was to evaluate the incidence of deep vein thrombosis and to assess the cut-off levels of serum D-dimer as a screening strategy for deep vein thrombosis during the perioperative period.

Methods: A total of 205 patients (ovarian cancer: 68, endometrial cancer: 76, cervical cancer: 61) who underwent gynecological surgery, including retroperitoneal lymph node dissection, were enrolled. Read More

J Pediatr Surg 2020 Mar 24. Epub 2020 Mar 24.

Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, Memphis, TN 38105, USA.

Background: Retroperitoneoscopic surgery (RS) is increasingly used for the diagnosis, staging, and treatment of solid tumors, but rarely in pediatric surgical oncology for retroperitoneal lymph node dissection (RPLND). Herein, we use single-site RS for RPLND in children and compare the perioperative outcomes with those for the transperitoneal laparoscopic approach (TPLA).

Methods: A single institution retrospective chart review was performed for patients undergoing single-site RS and TPLA (January 2018 till June 2019). Read More

Can Urol Assoc J 2020 Mar 30. Epub 2020 Mar 30.

Division of Urology, Department of Surgery, University Health Network, University of Toronto.

Can Urol Assoc J 2020 Mar 30. Epub 2020 Mar 30.

Division of Medical Oncology, Department of Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.

Introduction: Post-chemotherapy retroperitoneal lymph node dissection (PCRPLND) has a well-established role in the management of residual retroperitoneal masses >1cm in patients with advanced non-seminomatous germ cell tumor (NSGCT). Herein, we report our single-surgeon surgical experience in a Canadian tertiary hospital.

Methods: We identified 57 patients with NSGCT who received primary chemotherapy and PCRPLND from 2010-2016. Read More

Asia Pac J Clin Oncol 2020 Mar 27. Epub 2020 Mar 27.

Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Background: Postoperative ileus is a major complication of abdominal surgical procedures. The purpose of this study was to investigate preventive effect of daikenchuto (DKT) on onset of ileus in patients who received gynecological surgery for malignant tumors.

Methods: A total of 904 patients who received gynecological surgery for malignant tumors by opening retroperitoneum along with retroperitoneal lymph node dissection during a period between 2004 and 2018 were included in this retrospective study. Read More

Curr Oncol 2020 Feb 1;27(1):e34-e42. Epub 2020 Feb 1.

Department of Urology, Queen's University, and Kingston General Hospital, Kingston, ON.

Objective: The purpose of the present guideline is to recommend surgical or systemic treatment for metastatic testicular cancer; T3b or T4, or node-positive, and metastatic renal cell cancer (rcc); and T3, T4, or node-positive upper tract urothelial (utuc) cancer.

Methods: Draft recommendations were formulated based on evidence obtained through a systematic review of randomized controlled trials, comparative retrospective studies, and guideline endorsement. The draft recommendations underwent an internal review by clinical and methodology experts, and an external review by clinical practitioners. Read More

Zhonghua Nan Ke Xue 2019 Feb;25(2):144-149

Department of Urology / Urology Institute of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Objective: To compare the clinical characteristics of simple testicular yolk sac tumor (YST) in children with those in adults so as to improve the diagnosis and treatment of the malignance.

Methods: This study included 75 cases of simple testicular YST pathologically confirmed between May 2008 and July 2018, which were divided into groups A (aged <18 years, n = 64) and B (aged ≥18 years, n = 11). We analyzed the clinical data on all the cases and compared the clinical manifestations, laboratory results, pathological findings, clinical stages, treatment methods and prognostic outcomes between the two groups of patients. Read More

J Robot Surg 2020 Mar 21. Epub 2020 Mar 21.

Division of Urology at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.

The objective of this study is to determine recent trends in use of robotics and laparoscopy for pediatric retroperitoneal lymph-node dissection (RPLND) in pediatric and non-pediatric hospitals. We conducted a retrospective cohort study using data from 29 hospitals in the Pediatric Health Information System (PHIS), and data from 14 states in the State Inpatient Databases (SID), between 2008 and 2014. The study population was comprised of patients aged ≥ 10 years undergoing RPLND, with an inpatient diagnosis of testicular or paratesticular cancer, based on international classification of disease (ICD) codes. Read More

Eur J Surg Oncol 2020 Jun 26;46(6):999-1005. Epub 2020 Feb 26.

Dept. of Oncological Urology, University Medical Center Utrecht, Postbox 85500, 3508, GA, Utrecht, the Netherlands. Electronic address:

Post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) is an important element of the management of patients with residual tumour after chemotherapy for disseminated nonseminomatous germ cell tumour (NSGCT). This is a challenging procedure and the outcome varies widely between institutions. There is much debate concerning the anatomical extent of the dissection and the literature is conflicting regarding the outcome of this procedure. Read More

J Urol 2020 06 11;203(6):1064. Epub 2020 Mar 11.

Clin Transl Radiat Oncol 2020 May 26;22:9-14. Epub 2020 Feb 26.

Department of Radiation Oncology, NKI-AVL, Amsterdam, The Netherlands.

Purpose: Biochemical failure after external beam radiotherapy (RT) for node-positive prostate cancer (PC) frequently involves nodal recurrences, in most cases out of field. This raises the question if current RTOG-based elective nodal fields can still be considered optimal. Modern diagnostic tools like PSMA PET/CT and choline PET/CT can visualize nodal recurrences with unprecedented accuracy. Read More

Urology 2020 Jun 3;140:77-84. Epub 2020 Mar 3.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH.

Objectives: To present a comprehensive report regarding our experience with single-port robotic surgery in our first 100 consecutive patients. We describe the diversity of procedures that can be performed with this platform as well as the challenges and complications we had with the application of this novel technology.

Methods: Between September 2018 and August 2019, data on 100 patients who underwent single-port robotic surgery were consecutively collected. Read More

J Clin Oncol 2020 Apr 5;38(12):1338-1345. Epub 2020 Mar 5.

Division of Hematology and Medical Oncology, Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN.

Purpose: Presence of teratoma in patients with metastatic testicular germ cell tumor (GCT) is of unknown prognostic significance. We report survival outcomes of patients with or without teratoma in primary tumor and postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) specimen and assess impact on prognosis.

Patients And Methods: Patients with metastatic nonseminomatous GCT (NSGCT) who were evaluated at Indiana University between 1990 and 2016 and had primary testicular tumor specimen from orchiectomy (ORCH) were included. Read More

World J Clin Oncol 2020 Feb;11(2):103-109

Norton Cancer Institute, Norton Healthcare, Louisville, KY 40202, United States.

Background: Retroperitoneal lymph node dissection (RPLND) plays a diagnostic, therapeutic, and prognostic role in myriad urologic malignancies, including testicular carcinoma, renal cell carcinoma (RCC), and upper urinary tract urothelial carcinoma. RCC represents 2% of all cancers with approximately 25% of patients presenting with advanced disease. Clear cell RCC (CCRCC) is the most common RCC, accounting for 75%-80% of all RCC. Read More

J Clin Oncol 2020 Apr 28;38(12):1332-1337. Epub 2020 Feb 28.

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: The relapse rate after primary retroperitoneal lymph node dissection (RPLND) for patients with pathologic stage (PS) IIA nonseminomatous germ cell tumors (NSGCTs) is 10%-20% but increases to ≥ 50% for PS IIB disease. We report our experience with 2 cycles of adjuvant etoposide plus cisplatin (EP×2) after therapeutic primary RPLND.

Patients And Methods: All patients with PS II NSGCT seen at Memorial Sloan Kettering Cancer Center from March 1989 to April 2016 and who were planned to receive EP×2 were included. Read More

Onco Targets Ther 2020 28;13:791-801. Epub 2020 Jan 28.

First Department of Surgery, Faculty of Medicine, University of Fukui, Fukui 910-1193, Japan.

Background: Lymphoepithelioma-like carcinomas (LELCs), especially colorectal cancers (CRCs), are uncommon pathological phenotypes generally associated with poor aggressiveness and a preferable prognosis. However, PD-L1 overexpression in CRCs is associated with poor outcomes. We report a case of moderately differentiated adenocarcinoma with PD-L1 overexpression, an LELC component, and Crohn's-like lymphoid reaction (CLR) presenting with extreme locoregional aggression and complete remission with chemotherapy after noncurative excision. Read More

Int J Surg Case Rep 2020 11;67:262-266. Epub 2020 Feb 11.

Gastrointestinal Clinical Institute, Epworth Healthcare, Victoria, Australia; Department of Cancer Surgery, Peter MacCallum Cancer Centre, Victoria, Australia; Department of Surgery, Alfred Health, Victoria, Australia. Electronic address:

Introduction: Neuroendocrine tumours are the most common type of primary small bowel neoplasm. Consensus guidelines recommend a multimodal approach to treatment of such tumours, with aggressive surgical resection remaining the mainstay of management. There is evidence that complete mesocolic excision (CME) of lymph nodes is associated with superior oncological outcomes including longer disease-free survival in patients with colorectal cancer than standard lymph node dissection and there is increasing evidence to suggest that the robotic approach may be superior to laparoscopic or open CME. Read More

Urology 2020 May 18;139:71-77. Epub 2020 Feb 18.

Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address:

Objective: To define the relationship between urology relative value units (RVUs) and measures of surgical complexity and physician workload. Secondary objectives include: (1) identifying procedures with outlying RVU values for their measures of surgical complexity and workload; and (2) calculating projected RVU values for these procedures.

Methods: We obtained surgical case data for 71 urology current procedural terminology (CPT) codes from the 2017 American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database. Read More

Transl Androl Urol 2020 Jan;9(Suppl 1):S83-S90

Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.

The purpose of this review is to present a comprehensive and updated review of the literature and summary of the indications, risks and outcomes related to salvage, desperation and late relapse surgery for advanced testicular cancer. After completing a thorough review of the current literature, this review has attempted to provide an overview of the indications for salvage, desperation and late relapse retroperitoneal lymph node dissection (RPLND) followed by a summary of the histopathologic and clinical outcomes regarding each. Recent literature, combined with a significant contribution from historical studies suggest that while testicular cancer is a relatively uncommon malignancy overall, it represents the most common solid organ malignancy for young men. Read More

Transl Androl Urol 2020 Jan;9(Suppl 1):S74-S82

USC/Norris Comprehensive Cancer Center, Institute of Urology, Los Angeles, CA 90089, USA.

The surgical management of disseminated disease has long been an essential component in the management of patients with testis cancer. While the indications for surgery have been narrowed since the advent of cisplatin based chemotherapy, resection remains essential to provide long-term survival. The indications for surgery vary by histology and rely on adequate preoperative imaging to evaluate for residual disease. Read More

Transl Androl Urol 2020 Jan;9(Suppl 1):S66-S73

Swedish Urology Group, Seattle, WA, USA.

Retroperitoneal lymph node dissection (RPLND) can been employed as primary treatment for stage I non-seminomatous germ cell tumor (NSGCT) as well as for treatment of post-chemotherapy masses. Open RPLND (O-RPLND) has long been the standard approach for lymphadenectomy, but is associated with significant morbidity. Laparoscopic RPLND (L-RPLND) was developed to mitigate the morbidity associated with O-RPLND, but is a technically challenging procedure requiring significant experience with laparoscopic dissection and suturing to remove lymph nodes behind the great vessels and to control vascular injury. Read More

Transl Androl Urol 2020 Jan;9(Suppl 1):S45-S55

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Early stage nonseminomatous germ cell tumor (NSGCT) remains a treatable disease, with stage I cancer specific survival exceeding 95%. Using a risk-adapted approach; active surveillance (AS), adjuvant chemotherapy, and retroperitoneal lymph node dissection (RPLND) all options for treatment; with surveillance being increasingly used. With persistently elevated markers (stage IS), chemotherapy remains the hallmark of treatment. Read More

Transl Androl Urol 2020 Jan;9(Suppl 1):S36-S44

Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Therapy for early stage testicular seminoma has changed radically over the past several decades. Given high cure rates and clinical trials supporting less active therapy in most cases, close observation after radical orchiectomy is now considered standard of care for clinical stage (CS) IA/IB seminoma, with either radiation therapy (RT) or chemotherapy salvage options possible. For CS IIA/IIB seminoma characterized by non-bulky retroperitoneal lymph node involvement (≤5 cm in greatest dimension), RT or combination chemotherapy are the standard of care. Read More

Transl Androl Urol 2020 Jan;9(Suppl 1):S31-S35

Section of Urology, Department of Surgery, The University of Chicago Medicine, Chicago, IL, USA.

There is controversy in the management of patients with clinical stage I non-seminomatous germ cell tumor (NSGCT). Some experts recommend surveillance for all patients regardless of risk factors while others suggest a more risk-adapted approach by using lymphovascular invasion (LVI) and the embryonal component in the primary tumor to select patients most likely to benefit from primary treatment [retroperitoneal lymph node dissection (RPLND) or chemotherapy]. With the surveillance for all strategy, only patients who relapse are treated. Read More

BMJ Open 2020 02 10;10(2):e036609. Epub 2020 Feb 10.

USC Institute of Urology and Catherine and Joseph Aresty Department of Urology, University of Southern California, Los Angeles, California, USA.

Introduction: Minimally invasive surgery in urology has grown considerably in application since its initial description in the early 1990s. Herein, we present the protocol for a systematic review and meta-analysis comparing open versus robotic urological oncological surgery for various clinically relevant outcomes, as well as to assess their comparative penetrance over the past 20 years (2000-2020).

Methods And Analysis: We will document the penetrance of robotic versus open surgery in the urological oncological field using a national database. Read More

Oncologist 2020 Feb 11. Epub 2020 Feb 11.

Department of Urology, University Hospital, University of Zurich, Zurich, Switzerland.

Background: Sertoli cell tumors (SCTs) of the testes are rare, and the literature provides only weak evidence concerning their clinical course and management. The objective of this study was to summarize evidence on SCTs' clinical presentation, clinicopathological risk factors for malignancy, treatment options, and oncological outcomes.

Materials And Methods: Data sources included Medline, Embase, Scopus, the Cochrane Database of Systematic Reviews, and Web of Science. Read More

Integr Cancer Ther 2020 Jan-Dec;19:1534735419900554

Sant'Orsola-Malpighi Hospital, Bologna, Italy.

Primary soft tissue sarcomas arising from the male urinary and genital tract are rare tumors, only accounting for 1% to 2% of all malignancies of the genitourinary tract. Clinical management of advanced disease is lacking in standardized recommendations due to the rarity of the disease. To date, complete and extensive surgery represents the only curative and standardized approach for localized disease, while the impact of retroperitoneal lymphadenectomy and adjuvant treatments on clinical outcomes are still unclear. Read More

J Urol 2020 Jul 31;204(1):96-103. Epub 2020 Jan 31.

Department of Urology, Indiana University, Indianapolis, Indiana.

Purpose: We analyzed the oncologic outcomes of men undergoing primary retroperitoneal lymph node dissection and characterized the use of adjuvant chemotherapy and template dissections.

Materials And Methods: Retrospective review of the Indiana University testis cancer database identified patients who underwent primary retroperitoneal lymph node dissection between January 2007 and December 2017. Patients and providers were contacted to obtain information regarding adjuvant therapy, recurrence and survival. Read More