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Oncology (Williston Park) 2022 Jun;36(6):375-377

A man, aged 21 years, presented with a 4-month history of progressive swelling of the right testicle. Ultrasound revealed a heterogenous solid mass in the right testicle suspicious for malignancy. Further work-up included CT scans, which identified a 2-cm retroperitoneal lymph node; there was no evidence of thoracic metastases. Read More

Eur Urol 2022 Jun 16. Epub 2022 Jun 16.

Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Background: In a subset of patients with recurrent oligometastatic prostate cancer (PCa) salvage surgery with prostate-specific membrane antigen (PSMA)-targeted radioguidance (PSMA-RGS) might be of value.

Objective: To evaluate the oncological outcomes of salvage PSMA-RGS and determine the predictive preoperative factors of improved outcomes.

Design, Setting, And Participants: A cohort study of oligorecurrent PCa patients with biochemical recurrence (BCR) after radical prostatectomy and imaging with PSMA positron emission tomography (PET), treated with PSMA-RGS in two tertiary care centers (2014-2020), was conducted. Read More

Urol Ann 2022 Apr-Jun;14(2):196-198. Epub 2022 Apr 18.

Department of Urology, University Hospital HM Sanchinarro, HM Hospitales and ROC Clinic, Madrid, Spain.

Testicular cancer (TC) represents 1% of male neoplasms and 5% of urological tumors. Most of seminoma patients and about 55% of patients with nonseminoma TC have stage I disease at diagnosis. TC usually presents with a palpable testicular mass incidentally found by the patient himself or its partner by palpation. Read More

Urology 2022 Jun 7. Epub 2022 Jun 7.

Department of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou. Electronic address:

J Clin Oncol 2022 Jun 8:JCO2200118. Epub 2022 Jun 8.

Department of Urology, Indiana University School of Medicine, Indianapolis, IN.

Purpose: According to National Comprehensive Cancer Network guidelines, adjuvant chemotherapy (AC) has been advocated after primary retroperitoneal lymph node dissection (RPLND) to reduce the risk of relapse in pathologic nodal (pN) stage pN2 or pN3, whereas surveillance is preferred for pN1. We sought to explore the oncologic efficacy of primary RPLND alone for pathologic stage II in nonseminomatous germ cell tumors (NSGCTs) to reduce overtreatment with chemotherapy.

Methods: Patients with pathologic stage II NSGCT after primary RPLND between 2007 and 2017 were identified. Read More

Rev Assoc Med Bras (1992) 2022 Apr;68(4):524-529

Ege University Faculty of Medicine, Department of Urology - Izmir, Turkey.

Objective: Postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) plays an important role in the management of advanced germ cell testicular tumors. Bilateral template lymph node dissection is considered a standard treatment in postchemotherapy residual masses; however, modified unilateral templates have gained acceptance in patients with unilateral residual disease. In this study, we aimed to demonstrate the perioperative and oncological outcomes of the patients with advanced testicular cancer who underwent unilateral modified template PC-RPLND in our center. Read More

Vet Sci 2022 May 12;9(5). Epub 2022 May 12.

Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Yuseong-gu, DaeJeon 34134, Korea.

Tumors of sweat glands usually originate from apocrine glands and can develop throughout the body but are rare in dogs. This report describes the retroperitoneal metastasis of primary cutaneous apocrine adenocarcinoma. An 8-year-old, spayed female beagle dog, weighing 11. Read More

J Endourol 2022 May 24. Epub 2022 May 24.

Ijinkai Takeda General Hospital, Urology, Kyoto, Japan;

Objectives: To investigate the oncological outcomes and recurrence patterns of clinically node-negative patients with renal pelvic and/or upper or middle ureteral tumors after a template-based retroperitoneal lymph node dissection (RPLND) in conjunction with retroperitoneal laparoscopic radical nephroureterectomy (LRNU).

Methods: A total of 283 patients who received LRNU with and without RPLND at three Japanese institutions were enrolled. The template of RPLND included the renal hilar and paraaortic lymph nodes (LNs) (left side) and renal hilar, paracaval, retrocaval, and intra-aortocaval LNs (right side). Read More

Eur J Obstet Gynecol Reprod Biol 2022 Jul 18;274:68-72. Epub 2022 May 18.

Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.

The role of retroperitoneal staging in endometrial cancer is still unclear. Although the prognostic value of lymphadenectomy has been demonstrated no data support the therapeutic value of nodal dissection. Sentinel node mapping represents an evolution of lymphadenectomy. Read More

Asian J Urol 2022 Apr 25;9(2):119-124. Epub 2021 May 25.

Department of Urology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan.

Objective: This study was performed to evaluate the clinical and perioperative outcomes of laparoscopic retroperitoneal lymph node dissection (L-RPLND) and open retroperitoneal lymph node dissection (O-RPLND) performed by one surgeon at a single center.

Methods: We evaluated 30 patients with stage IIA germ cell tumors who underwent retroperitoneal lymph node dissection (15 underwent L-RPLND and 15 underwent O-RPLND) at our institution between April 1, 2010 and March 31, 2018. The clinical parameters were compared between patients who underwent L-RPLND using the retroperitoneal approach and those who underwent O-RPLND using the transperitoneal approach. Read More

Scott Med J 2022 May 4:369330221099619. Epub 2022 May 4.

Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Cancer Research UK Barts Centre, 4617Queen Mary University of London, London, UK.

Background And Aims: Testicular Germ Cell Tumours (TGCTs) are the commonest young adult male cancer, with excellent survival outcomes even with metastatic disease. Chemotherapy, radiotherapy, and surgery are international guideline-dictated standard of care (SOC) treatments for International Germ Cell Cancer Collaborative Group (IGCCCG) "good risk" TGCT, but are associated with significant toxicities. Therapy de-escalation aims to reduce treatment morbidity whilst preserving cure rates, and has been adopted by some centres for stage IIA/B seminoma. Read More

J Pediatr Urol 2022 Jun 3;18(3):401-403. Epub 2022 Mar 3.

Pediatric Urology Divion, Urology Department, Fundació Puigvert, Universidad Autónoma de Barcelona, Barcelona, Spain. Electronic address:

Introduction: Paratesticular sarcoma is an aggressive malignant tumor of mesenchymal origin. The rhabdomyosarcoma is the most common among children. Rhabdomyosarcoma treatment consists of surgery, chemotherapy and radiotherapy. Read More

Cureus 2022 Mar 6;14(3):e22885. Epub 2022 Mar 6.

Hematology and Medical Oncology, HCA Houston Healthcare Kingwood Medical Center, Kingwood, USA.

A 25-year-old male presented to our hospital with two months of progressively worsening left arm swelling, intermittent left-sided chest pressure, and a painless right testicular mass. CT of the chest, abdomen, and pelvis revealed a large mediastinal mass, multiple lung nodules, and several large right testicular nodules. The patient underwent a CT-guided biopsy of his right lung nodule, followed by a radical right inguinal orchiectomy. Read More

Dis Colon Rectum 2022 Apr 5. Epub 2022 Apr 5.

General and Digestive Surgery Department, Reina Sofía University Hospital, Cordoba, Spain.

Nagoya J Med Sci 2022 Feb;84(1):200-207

Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Surgical resection is the mainstay of treatment for retroperitoneal liposarcoma (RPLS). Herein, we describe a case of dedifferentiated RPLS successfully treated with an extended surgical approach with adjuvant chemotherapy. A 61-year-old male was referred to our hospital with a chief complaint of chest tightness. Read More

Asian J Androl 2022 Apr 5. Epub 2022 Apr 5.

Department of Urology, European Institute of Oncology, IRCCS, Milan 20141, Italy.

Sexual disorders following retroperitoneal pelvic lymph node dissection (RPLND) for testis tumor can affect the quality of life of patients. The aim of the current study was to investigate several different andrological outcomes, which may be influenced by robot-assisted (RA) RPLND. From January 2012 to March 2020, 32 patients underwent RA-RPLND for stage I nonseminomatous testis cancer or postchemotherapy (PC) residual mass. Read More

Cureus 2022 Feb 14;14(2):e22210. Epub 2022 Feb 14.

Urology, Spokane Urology, Spokane, USA.

Adenocarcinoma of the rete testis is an extremely rare and aggressive tumor that carries a poor prognosis. Successful long-term treatment for such tumors remains elusive as more cases are discovered worldwide. Treatment typically involves radical orchiectomy, retroperitoneal pelvic lymph node dissection, adjuvant chemotherapy, and/or continued surveillance. Read More

Malawi Med J 2021 12;33(4):300-302

Fenerbahçe University, Faculty of Health Sciences, Department of Midwifery, Istanbul/Turkey.

Castleman's disease was first described by Castleman et al. in 1956 as a non-lymphoproliferative disease.1 Castleman's disease (CD), or angiofollicular lymphoid hyperplasia, is a rare disease with unknown etiology that can be easily misdiagnosed as lymphoma, neoplasm, or infection. Read More

Front Oncol 2022 24;12:791140. Epub 2022 Feb 24.

Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Purpose: To determine the safety and feasibility of extraperitoneal laparoscopic extended lymph node dissection (LND) at the time of extraperitoneal laparoscopic radical nephroureterectomy (RNU).

Materials And Methods: Between May 2018 and March 2019, 39 patients with upper tract urothelial carcinoma (UTUC) received extraperitoneal laparoscopic RNU and concomitant extraperitoneal laparoscopic extended LND. All patients were followed for at least 90 days. Read More

World J Urol 2022 Jun 13;40(6):1505-1512. Epub 2022 Mar 13.

Department of Urology, Luzerner Kantonsspital, Luzern, Switzerland.

Purpose: To describe the perioperative safety, functional and immediate post-operative oncological outcomes of minimally invasive RPLND (miRPLND) for testis cancer.

Methods: We performed a retrospective multi-centre cohort study on testis cancer patients treated with miRPLND from 16 institutions in eight countries. We measured clinician-reported outcomes stratified by indication. Read More

Case Rep Rheumatol 2022 25;2022:5298960. Epub 2022 Feb 25.

Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco.

Introduction: The clinical manifestations of Hodgkin lymphoma (HL) can closely mimic spine and lymph node tuberculosis (TB). . A 48-year-old man was initially treated for retroperitoneal lymph nodes TB, and this diagnosis was made without bacteriological and histopathological confirmation. Read More

Can Urol Assoc J 2022 Mar;16(3):E167-E172

Department of Urology, UT Southwestern Medical Center, Dallas, TX, United States.

Introduction: We aimed to determine whether anti-1-amino-3-F-fluorocyclobutane-1-carboxylic acid (F-fluciclovine) positron emission tomography/computed tomography (PET/CT) can accurately detect residual non-seminomatous germ cell tumor (NSGCT) prior to retroperitoneal lymph node dissection (RPLND). There is no reliable way to differentiate between fibrosis/necrosis, teratoma, and viable germ cell tumor in patients receiving post-chemotherapy RPLND. Functional imaging, including F-fludeoxyglucose (18F-FDG) PET/CT, has been disappointing. Read More

Cureus 2022 Jan 25;14(1):e21603. Epub 2022 Jan 25.

Department of Radiation Oncology, Iran University of Medical Sciences, Tehran, IRN.

Spontaneous primary tumor regression, or burned-out tumors, refers to the presence of a metastatic tumor with the histological regression of the primary lesion. The burned-out phenomenon has been reported in various malignancies, with testicular germ cell tumors (GCTs) accounting for a significant share of these cases. However, burned-out testicular tumors are a rare clinical phenomenon and are generally difficult to diagnose, as there is no evidence of primary testicular cancer. Read More

Clin Case Rep 2022 Feb 23;10(2):e05409. Epub 2022 Feb 23.

Urologist Burjeel Hospital Abu Dhabi UAE.

Leiomyosarcoma is a rarely seen neoplasm of the ureter. Malignant tumors of smooth muscle of the ureter are extremely rare, and about 22 cases of leiomyosarcoma of ureter have been reported to date. A 57-year-old diabetic Pakistani man presented with a dull ache pain in the right flank. Read More

J Urol 2022 07 25;208(1):53-61. Epub 2022 Feb 25.

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida.

Purpose: Chylous ascites (CA) is an uncommon complication that occurs from traumatic disruption of lymphatic channels after retroperitoneal surgery. The purpose of this study was to generate an evidence-based management strategy for CA by reviewing the current literature and available treatment modalities.

Materials And Methods: A MEDLINE® literature review was performed for "chylous ascites. Read More

J Clin Med 2022 Feb 11;11(4). Epub 2022 Feb 11.

Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Lymphadenectomy has been an essential part of the surgical treatment in surgical oncology, as the lymphatic channels and nodes are the main dissemination pathway for most of the gynecological cancers. Pelvic and paraaortic lymphadenectomy are frequent surgical procedures in gynecologic oncology. Paraaortic lymph node dissection facilitates staging, prognosis, surgical and postoperative management of patients. Read More

Eur Urol Oncol 2022 04 17;5(2):244-245. Epub 2022 Feb 17.

Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Università degli Studi di Milano, Milan, Italy.

J Minim Invasive Gynecol 2022 05 10;29(5):588. Epub 2022 Feb 10.

Department of Obstetrics and Gynecology, Strasbourg University Hospital (all authors).

Study Objective: To describe the anatomy of the nerves during a laparoscopic retroperitoneal para-aortic lymphadenectomy with prioritization of their preservation.

Design: Demonstration of a nerve-preserving para-aortic lymphadenectomy.

Setting: A 65-year-old woman with no significant medical history underwent diagnostic laparoscopy for evaluation of a right ovarian mass. Read More

Int J Urol 2022 05 10;29(5):455-461. Epub 2022 Feb 10.

Department of Urology, Ijinkai Takeda General Hospital, Kyoto, Japan.

Objectives: To describe the detailed perioperative complications and their management after retroperitoneal lymph node dissection with retroperitoneal laparoscopic radical nephroureterectomy for patients with upper tract urothelial carcinoma at three institutions.

Methods: Retroperitoneal lymph node dissection was performed on patients with upper tract urothelial carcinoma located at the pelvis and/or upper or middle ureter, and its template included the renal hilar and para-aortic lymph nodes (left side) and the renal hilar, paracaval, retrocaval, and intra-aortocaval lymph nodes (right side). The lymph nodes and kidneys were removed en bloc. Read More

Dis Colon Rectum 2022 03;65(3):e179

Colorectal Division, Department of GI & HPB Surgery, Tata Memorial Centre, Mumbai, India.