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Int J Urol 2021 Jun 3. Epub 2021 Jun 3.

Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Objectives: To evaluate the histologic findings and clinical outcomes of post-chemotherapy retroperitoneal lymph node dissection for advanced germ cell tumor.

Methods: We analyzed the medical records of 66 patients who underwent post-chemotherapy retroperitoneal lymph node dissection between 2005 and 2019 at Tsukuba University Hospital.

Results: The proportions of necrosis, teratoma, and viable germ cell tumor in the specimens were 62. Read More

Sci Rep 2021 May 21;11(1):10700. Epub 2021 May 21.

Department of Urology and Paediatric Urology, Saarland University Medical Centre and Saarland University Faculty of Medicine, Homburg, Saar, Germany.

Data on robotic retroperitoneal lymph node dissection (R-RPLND) for metastatic testicular germ cell tumours (mTGCTs) are scarce and the use of R-RPLND itself is still under debate. The aim of our study was to evaluate the indications, feasibility and outcomes of R-RPLND, with special emphasis on differences between primary R-RPLND (pR-RPLND) and post-chemotherapeutic R-RPLND (pcR-RPLND) in mTGCTs. We retrospectively analysed the data of patients who underwent R-RPLND for mTGCT between November 2013 and September 2019 in two centres in Germany. Read More

Eur Urol Open Sci 2021 Apr 5;26:83-87. Epub 2021 Mar 5.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Existing tumor markers for testicular germ cell tumor (TGCT) cannot detect the presence of pure teratoma. Serum miRNAs have strong performance detecting other subtypes of TGCT. Previous reports suggest high levels of miR-375 expression in teratoma tissue. Read More

Asian J Urol 2021 Apr 6;8(2):161-169. Epub 2021 Mar 6.

Department of Urology, University of Duesseldorf, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.

Germ cell cancers are the most common solid tumors among men between 15 and 40 years. Non-seminomatous germ cell tumors (NSGCTs) represent a unique and exclusive cohort of germ cell tumor patients. Non-seminoma can harbor different histologic components. Read More

J Robot Surg 2021 May 12. Epub 2021 May 12.

Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, 610 University Avenue, Suite 3-130, Toronto, ON, M5G 1X5, Canada.

The role of retroperitoneal lymph node dissection (RPLND) in testicular cancer is well established in both the primary and post-chemotherapy setting. The aim of this study was to report our 2 years oncological outcomes of robotic RPLND. A retrospective review was performed of all patients undergoing robotic RPLND by a single surgeon at Princess Margaret Cancer Centre. Read More

Int J Gynecol Cancer 2021 May 12. Epub 2021 May 12.

Gynecologic Oncology, N.N. Blokhin National Medical Research Center of Oncology оf the Ministry of Health of the Russian Federation, Moscow, Russian Federation.

Surg Endosc 2021 May 12. Epub 2021 May 12.

Department of Gastroenterological Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka City, Osaka, 543-0035, Japan.

Introduction: Single-port laparoscopic extended right hemicolectomy with complete mesocolic excision and central vascular ligation is technically challenging, and a standardized procedure is needed to minimize technical hazards.

Technique: As a first step, the hepatic flexure is mobilized from the duodenum, and the third part of the duodenum and pancreatic head was exposed. Next, the ileocecal vessels are divided at the root using a medial-to-lateral approach, and the cecum is separated from the retroperitoneal space. Read More

J Pediatr Surg 2021 Apr 15. Epub 2021 Apr 15.

Department of Surgery, Mott Children's Hospital, University of Michigan, Ann Arbor, MI, United States.

Background: Testicular germ cell tumors are uncommon tumors that are encountered by pediatric surgeons and urologists and require a knowledge of appropriate contemporary evaluation and surgical and medical management.

Method: A review of the recommended diagnostic evaluation and current surgical and medical management of children and adolescents with testicular germ cell tumors based upon recently completed clinical trials was performed and summarized in this article.

Results: In this summary of childhood and adolescent testicular germ cell tumors, we review the initial clinical evaluation, surgical and medical management, risk stratification, results from recent prospective cooperative group studies, and clinical outcomes. Read More

Transl Androl Urol 2021 Apr;10(4):1647-1655

Department of Urology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Background: To identify a combination of microRNAs (miRNA) to differentiate between viable tumor (V) or teratoma (T) and necrosis/fibrosis (N) in pcRPLND specimens of metastatic germ cell tumor (GCT) patients with residual masses ≥1 cm after chemotherapy. Biomarker guided therapy could reduce overtreatment with pcRPLND in patients with only N.

Methods: We selected 48 metastatic GCT patients who had undergone pcRPLND. Read More

World J Urol 2021 May 7. Epub 2021 May 7.

Department of Urology, Naval Medical Center San Diego, San Diego, CA, USA.

Objective: To evaluate the perioperative and oncological outcomes after post-chemotherapy robot-assisted retroperitoneal lymph node dissection (PC-RARPLND).

Materials And Methods: We retrospectively reported the perioperative and oncological outcomes of all the patients with testicular cancer who underwent PC-RARPLND at three tertiary teaching centers. Descriptive statistical measures were used to report demographic, clinical, intraoperative, postoperative and oncological outcomes. Read More

Am J Case Rep 2021 May 4;22:e929511. Epub 2021 May 4.

General Surgery Division, Hospital das Clínicas at Federal University of Pernambuco (HC/UFPE), Recife, PE, Brazil.

BACKGROUND Mixed adenoneuroendocrine carcinoma of the gallbladder (gMANEC) is an extremely rare cancer. Most of the cases are reported in Asia, North America, and Europe, with no cases reported in Latin America; this is the first report for this region, and the 24th case reported worldwide. CASE REPORT A 68-year-old woman was referred to our department due to asthenia and moderate abdominal pain in the right upper quadrant for 6 months, with imaging examinations showing a solid heterogeneous expansive lesion in gallbladder topography and segment IV of the liver. Read More

Int J Urol 2021 Apr 27. Epub 2021 Apr 27.

Department of Urology, Ijinkai Takeda General Hospital, Kyoto, Japan.

Ecancermedicalscience 2021 11;15:1204. Epub 2021 Mar 11.

Department of Urosurgery, Tata Medical Center, 14 MAR (EW), New Town, Rajarhat, Kolkata 700160, India.

Non-seminomatous germ cell tumour (NSGCT) is a rare but highly curable malignancy. The literature on the management and outcomes of NSGCT is scarce from India. Here, we report the demography and treatment outcomes of NSGCT treated at our centre. Read More

Indian J Urol 2021 Jan-Mar;37(1):32-41. Epub 2021 Jan 1.

Department of Urology, Renal Transplantation, Robotics and Uro-Oncology, Max Hospital, New Delhi, India.

With the rapid expansion of robotic platforms in urology, there is an urgent and unmet need to review its cost and benefits in comparison to the traditional laparoscopy, especially in reference to a developing country. A nonsystematic review of the literature was conducted to compare the outcomes of pure laparoscopic and robot-assisted urologic procedures. Available literature over the past 30 years was reviewed. Read More

J Gynecol Oncol 2021 May;32(3):e40

Department of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

Objective: To estimate the impact of lymph node dissection on survival in patients with apparent early-stage epithelial ovarian cancer (EOC).

Methods: We conducted a retrospective review of patients with clinical stage I-II EOC. All patients underwent primary surgery at Sun Yat-sen University Cancer Center between January 2003 and December 2015. Read More

J Clin Oncol 2021 Apr 6:JCO2002871. Epub 2021 Apr 6.

Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.

Purpose: Adrenocortical carcinoma (ACC) is a rare aggressive pediatric malignancy with distinct biology. Its treatment follows the principles developed for adults; pediatric-specific studies are scarce.

Patients And Methods: Prospective single-arm risk-stratified interventional study. Read More

Acta Oncol 2021 Apr 5:1-9. Epub 2021 Apr 5.

Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Introduction: Post-chemotherapy surgery constitutes an integral part of the management of patients with non-seminomatous germ-cell tumours with a residual mass in the retroperitoneum. Published data on recurrence rates and complications to bilateral retroperitoneal lymph node dissection (RPLND), unilateral template RPLND, and resection of residual mass only according to different surgical techniques (open, laparoscopic, and robotic surgery) were reviewed.

Material And Methods: PubMed/Medline, Embase, and the Cochrane databases were searched systematically. Read More

Front Oncol 2021 17;11:629878. Epub 2021 Mar 17.

Department of Urology, Jinhua Hospital Affiliated to Zhejiang University School of Medicine, Jinhua, China.

Paratesticular rhabdomyosarcoma (RMS) accounts for only 7% of all the RMS cases. Due to the limited available data, there is no consensus on the diagnosis and management of the paratesticular tumors. Here, we interrogated two paratesticular RMS cases in 25 and 27-year-old men presenting with painless and rapidly growing mass in the scrotum. Read More

Case Rep Gastroenterol 2021 Jan-Apr;15(1):269-275. Epub 2021 Mar 4.

Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.

We present the case of a 35-year-old man with intractable nausea, vomiting, and severe anemia. A computed tomography (CT) scan of the chest, abdomen, and pelvis showed a circumferential lesion thickening of up to 3.5 cm at the level of the third portion of the duodenum. Read More

Urology 2021 Mar 27. Epub 2021 Mar 27.

Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Urology, Miyagi Cancer Center, Natori, Japan.

Objective: To evaluate the health-related quality of life (QOL) of testicular cancer (TC) survivors using the Japanese version of the EORTC QLQ-TC26 questionnaire in a multi-institutional, cross-sectional study.

Methods: This study recruited TC survivors who were followed after treatment for TC at eight high-volume institutions between January, 2018 and March, 2019. The participants completed the EORTC QLQ-TC26 questionnaire and mailed the completed questionnaires to a central institution. Read More

Clin Nucl Med 2021 Jul;46(7):e347-e348

Nuclear Medicine, Bezmialem Vakıf University Faculty of Medicine, Istanbul, Turkey.

Abstract: A 40-year old man admitted to the nuclear medicine department to undergo PET/CT for restaging of known testicular germ cell tumor. The patient had a history of orchiectomy for left testis and left nephrectomy with retroperitoneal lymph node dissection. Histopathology revealed testicular germ cell tumor. Read More

Eur Urol Oncol 2021 Mar 6. Epub 2021 Mar 6.

Department of Clinical Science, Intervention and Technology, Division of Urology, Karolinska Institutet, Stockholm, Sweden; Department of Urology, Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden.

Background: The distribution of retroperitoneal lymph node metastases for patients with nonseminoma and a residual tumour of 10-49 mm in a population-based setting is unknown. This information is needed to justify selection of patients for a unilateral template resection.

Objective: To describe the location of retroperitoneal metastases and recurrences in patients with nonseminoma germ cell tumour (NSGCT) with a residual tumour of 10-49 mm. Read More

Medicine (Baltimore) 2021 Mar;100(10):e25088

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Abstract: Diagnosis of unicentric Castleman disease (UCD) is not easy before the resection and obtainment of pathological result. We retrospectively summarized 10-year experience of clinical evaluation and management for retroperitoneal UCD in Peking Union Medical College Hospital (PUMCH) between December 1, 2009 and December 31, 2019. Seventy two UCD patients with pathological diagnosis after resection were screened out. Read More

IJU Case Rep 2021 Mar 31;4(2):86-88. Epub 2021 Jan 31.

Department of Urology University of Tsukuba Hospital Tsukuba Ibaraki Japan.

Introduction: A double inferior vena cava is a rare anomaly with an incidence ranging from 0.3% to 3.0%. Read More

Gynecol Oncol Rep 2021 May 4;36:100709. Epub 2021 Feb 4.

Oxford University Hospitals NHS Foundation Trust, Department of Gynae-Oncology, Churchill Hospital, Old Road, Headington OX3 7LE, United Kingdom.

The findings of the DESKTOP 3 (Du Bois et al., 2017) ​study advocate secondary cytoreduction in patients with disease relapse of ovarian or peritoneal malignancy meeting specified criteria. We present a surgical video demonstrating the technique of laparoscopic resection of single site pelvic side wall recurrence 6 years after stage IIIc high grade serous primary peritoneal cancer. Read More

Ann Surg Oncol 2021 Jul 10;28(7):3648-3655. Epub 2021 Mar 10.

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Purpose: Following radical orchiectomy, surveillance and primary retroperitoneal lymph node dissection (RPLND) are acceptable options for the management of early stage pure testicular teratoma in adult patients; however, there is no uniform consensus. The aim of this study was to investigate survival outcomes of adults with early stage pure testicular teratoma based on management strategy.

Methods: Data was extracted from the National Cancer Database (NCDB) from testicular cancer patients diagnosed with clinical stage (CS) I pure teratoma (pT1-4N0M0S0) between 2004 and 2014. Read More

Surg Case Rep 2021 Mar 8;7(1):65. Epub 2021 Mar 8.

Division of Gastroenterological Surgery, Department of Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Background: Undescended testes are associated with an increased risk of malignancy and infertility, and surgical treatment in childhood is recommended.

Case Presentation: A 35-year-old man presented to the emergency department with abdominal pain and vomiting. Despite a history of surgery for a left undescended testis in infancy, his left-sided scrotum appeared underdeveloped. Read More

Gynecol Oncol 2021 May 5;161(2):347-352. Epub 2021 Mar 5.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Objectives: To assess associations between treatment and recurrence-free survival (RFS) among patients with isolated tumor cells (ITCs) in sentinel lymph nodes (SLN) and otherwise stage I/II endometrioid endometrial cancer (EC).

Methods: A multi-institutional retrospective study of patients with SLN ITCs (<200 cells and < 0.2 mm) was performed. Read More

BMC Surg 2021 Mar 6;21(1):116. Epub 2021 Mar 6.

Department of Urology, Montefiore Medical Center, Bronx, NY, USA.

Background: The first wave of the COVID-19 pandemic in March 2020 forced our healthcare system in the Bronx, New York to cancel nearly all scheduled surgeries. We developed a framework for prioritizing postponed urologic surgeries that was utilized once cases were permitted to be rescheduled. As many parts of our country experience first and second waves of this pandemic, our framework may serve as a resource for other centers experiencing restrictions on the scheduling of elective urologic surgeries. Read More

Int J Surg Case Rep 2021 Mar 14;80:105650. Epub 2021 Feb 14.

Department of Surgery, University of Minnesota, Minneapolis, MN, USA; University of Minnesota Medical School, Minneapolis, MN, USA. Electronic address:

Background: Castleman disease (CD) is a rare lymphocytic disorder. Unicentric CD (UCD) has an excellent long-term prognosis after surgical excision; however, multicentric CD (MCD) has a severe clinical course with poor outcomes.

Study Design: We analyzed the clinical presentation of 28 patients treated at a single institution from 1995 to 2017. Read More