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Cancer Epidemiol 2019 Feb 13;59:135-142. Epub 2019 Feb 13.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Québec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada.

Background: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age.

Materials And Methods: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified. Read More

Minerva Urol Nefrol 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, University of Verona, Verona, Italy.

Background: To assess the anatomical prevalence and secondary involvement of Cloquet's nodes in patients undergoing robotic radical prostatectomy (RRP) and extended pelvic lymph node dissection (ePLND) for prostate cancer (PCa).

Methods: RRP and ePLND were performed by two expert surgeons (WA and VDM). Data were prospectively collected and retrospectively analysed. Read More

J Med Case Rep 2019 Feb 14;13(1):34. Epub 2019 Feb 14.

Surgical Oncology Department, Institute Salah Azaiez de Cancer, Tunis, Tunisia.

Introduction: Cutaneous metastatic disease arising from urinary tract carcinoma is rare and associated with a poor prognosis. We report a case of metastatic disease occurring in a patient treated for synchronous urothelial tumor of the bladder and left renal pelvis.

Case Presentation: A 61-year-old Caucasian man was treated for a synchronous urothelial tumor of the bladder and left renal pelvis. Read More

PLoS One 2019 11;14(2):e0211675. Epub 2019 Feb 11.

Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan.

Background: Surgical indications for rectal neuroendocrine tumors with potential lymph node metastasis remain controversial. Although accurate preoperative diagnosis of nodal status may be helpful for treatment strategy, scant data about clinical values of lymph node size have been reported. The aim of this retrospective study was to investigate the relationship between lymph node size and lymph node metastasis. Read More

J Urol 2019 Feb 5. Epub 2019 Feb 5.

Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY.

Background: Bladder cancer recurrence following cystectomy remains a significant cause of bladder cancer-specific mortality. Residual cancer cells (RCCs) contribute to cancer recurrence due either to tumor spillage or undetectable pre-existing micrometastatic tumor clones. We sought to detect and quantify RCCs in pelvic washing using ultra-deep targeted sequencing (UTS) and compare the levels of RCCs with clinical variables and cancer recurrence. Read More

Curr Opin Urol 2019 Feb 5. Epub 2019 Feb 5.

Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida, USA.

Purpose Of Review: Penile cancer is a rare disease with significant physical and psychosocial morbidity. It has a propensity to spread to the inguinal lymph nodes where it can progress to the pelvis and beyond. Here, we present a contemporary review on the surgical management of the lymph nodes. Read More

Int J Clin Oncol 2019 Feb 5. Epub 2019 Feb 5.

Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: For rectal cancer, multimodality therapeutic approach is necessary to prevent local recurrence and distant metastasis. However, the efficacy of additional treatments, such as neoadjuvant chemoradiotherapy (nCRT), neoadjuvant chemotherapy (NAC), and lateral pelvic lymph node dissection (LPLND), has not been scrutinized.

Methods: Recurrence patterns were categorized into local recurrence and distant metastasis. Read More

Int J Gynecol Cancer 2019 Feb 18;29(2):312-319. Epub 2019 Jan 18.

Department of Gynecology and Obstetrics, University of Parma, Parma, Italy.

Objective: To determine the incidence of long term lymphadenectomy complications in primary surgery for endometrial cancer and to elucidate risk factors for these complications.

Methods: A retrospective chart review was carried out for all patients with endometrial cancer managed at Parma University Hospital Unit of Gynecology and Obstetrics between 2010 and 2016. Inclusion criteria were surgical procedure including hysterectomy and lymphadenectomy (pelvic or pelvic and aortic). Read More

Int J Gynecol Cancer 2019 Feb 21;29(2):282-289. Epub 2018 Dec 21.

Department of Obstetrics and Gynaecology, Centre Hospitalier Régional Universitaire, Lille, France.

Objective: The role of lymphadenectomy in intermediate risk endometrial cancer remains uncertain. We evaluated the impact of lymphadenectomy on overall survival and relapse-free survival for patients with intermediate risk endometrial cancer.

Methods: We retrospectively reviewed patients from the FRANCOGYN database with intermediate risk endometrial cancer, based on pre-operative and post-operative criteria (type 1, grade 1-2 tumors with deep (> 50%) myometrial invasion and no lymphovascular space invasion), who received primary surgical treatment between November 2002 and August 2013. Read More

J Vasc Interv Radiol 2019 Feb;30(2):195-202.e1

Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea.

Purpose: To compare the efficacy of lymph node (LN) embolization using N-butyl cyanoacrylate versus ethanol sclerotherapy in the management of symptomatic postoperative pelvic lymphorrhea.

Materials And Methods: Thirty-three patients with 40 instances of symptomatic postoperative lymphorrhea were treated with either LN embolization or sclerotherapy at Seoul National University Hospital from January 2009 to July 2017 and were retrospectively included (LN embolization group: 24 lymphoceles of 19 patients, mean age of 59.29 years; sclerotherapy group: 16 lymphoceles of 14 patients, mean age of 60. Read More

Asian J Endosc Surg 2019 Feb 3. Epub 2019 Feb 3.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Thymic carcinoma, a rare mediastinal neoplasm, is characterized by extensive local invasion and distant metastasis. To our knowledge, this is the first case report demonstrating the efficacy of laparoscopic dissection for pelvic lymph node metastases from thymic carcinoma. A 64-year-old man was found to have a mediastinal mass by CT and underwent radical resection. Read More

Anticancer Res 2019 Feb;39(2):993-998

Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Aim: To evaluate the clinical significance of lateral pelvic lymph node (LLN) size in predicting pathological metastasis and prognosis in rectal cancer treated with preoperative chemoradiotherapy (CRT) followed by surgery.

Patients And Methods: Fifty-two patients with rectal cancer who underwent curative surgery after preoperative CRT were included. Fifteen patients underwent total mesorectal excision (TME) alone, while 37 patients underwent TME with LLN dissection for clinical LLN metastasis. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2084-2086

Dept. of Surgery, Shuuwa General Hospital.

A 60-year-old male undergoing pelvic evisceration with D3 lymph node dissection for pR0 in 2006f or carcinoma of the rectum was diagnosed pathologically with moderately differentiated adenocarcinoma, fStage ⅡA(UICC pT3, pN0, M0). Follow-up CT revealed hypovascular liver tumors with intrahepatic bile duct dilation in the right lobe 8 years after the pelvic evisceration. We conducted right lobe hepatectomy. Read More

Curr Probl Cancer 2019 Jan 17. Epub 2019 Jan 17.

Department of Urology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of SUN YAT-SEN University, Jiangmen, Guangdong, China.

Background: Hepatoid adenocarcinoma arising from urological system is extremely rare, and the pathogenesis and therapeutic regimen have been poorly understood.

Case Report: we report a unique case of ɑ-fetaprotein (AFP)-producing neoplasm of renal pelvis associated with nephrolithiasis. A 59-year-old male patient was diagnosed with right renal tumor and nephrolithiasis with no evidence of lesions in his digestive or reproductive system. Read More

BJU Int 2019 Jan 25. Epub 2019 Jan 25.

University College London Hospital NHS Foundation Trust, London, UK.

Objectives: To analyse the peri-operative and oncological outcomes of all RPs performed for high risk prostate cancer(PCa) in the British Association of Urological Surgeons (BAUS) national registry from 2014-2015.

Patients And Methods: We identified and analysed outcomes of all RPs performed for high-risk PCa(clinical stage>T2 and/or biopsy Gleason Grade>7 and/or pre-operative PSA≥20) in the national registry for 2014 and 2015. Surgeon reporting of data was mandated during this period. Read More

J Urol 2019 Jan 21. Epub 2019 Jan 21.

Wesley Medical Imaging, Brisbane, Queensland, Australia.

Purpose: The majority of men who undergo pelvic lymph node dissection at radical prostatectomy have benign lymph node histology. The aim of this study was to assess the predictive value of preoperative Ga-PSMA (prostate specific membrane antigen) positron emission tomography/computerized tomography to predict histological metastasis on pelvic lymph node dissection performed during radical prostatectomy.

Materials And Methods: We retrospectively reviewed the sensitivity, specificity, and positive and negative predictive values of preoperative staging Ga-PSMA positron emission tomography/computerized tomography to identify histological lymph node metastasis in 208 consecutive men who subsequently proceeded with pelvic lymph node dissection at radical prostatectomy. Read More

Eur Radiol 2019 Jan 21. Epub 2019 Jan 21.

Department of Nuclear Medicine, Hôpital Foch, Université Versailles-Saint-Quentin-en-Yvelines, Université Paris-Saclay, 40, Rue Worth, 92150, Suresnes, France.

Objectives: Preoperative F-fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT) is controversial to assess lymph node (LN) staging in patients with invasive bladder cancer. We proposed to use the maximum standardized uptake value (SUV) associated with axial-based LN size to improve the detection of regional LN metastasis.

Methods: From May 2015 to May 2017, we prospectively included patients with urothelial bladder cancer who underwent radical cystectomy with extended pelvic LN dissection. Read More

Gynecol Oncol 2019 Jan 16. Epub 2019 Jan 16.

Department of Gynecological Oncology, Metaxa Memorial Cancer Hospital, Piraeus, Greece.

Purpose: The aim of the present study was to evaluate the correlation between the use of fibrin-collagen sealants on lymph node dissection areas and formation of lymphocele after lymphadenectomy in patients with gynecological malignancies.

Materials And Methods: A systematic search of 5 electronic databases for articles published up to November 2018 was performed. All randomized controlled clinical trials (RCTs) which reported outcomes after application of fibrin collagen agents in patients who underwent lymphadenectomy for gynecological malignancies, were finally included in the present meta-analysis. Read More

Int J Gynecol Cancer 2019 Jan 18. Epub 2019 Jan 18.

Department of Gynecologic and Breast Surgery and Oncology, AP-HP, Pitié-Salpêtrière University Hospital, Paris, France.

The role of pelvic sentinel lymph node dissection (SLND) is increasing in oncological pelvic surgery, especially in the management of cervical and endometrial cancer.SLND using indocyanine green (ICG) is safe and effective, and its sensitivity is higher than with other detection methods. The advantages of ICG are its low toxicity, its confinement within the vascular compartment, its rapid excretion, and the rarity of allergic reaction. Read More

Int J Gynecol Cancer 2019 Jan 18. Epub 2019 Jan 18.

Department of Gynecology and Obstetrics, University of Parma, Parma, Italy.

Objective: To determine the incidence of long term lymphadenectomy complications in primary surgery for endometrial cancer and to elucidate risk factors for these complications.

Methods: A retrospective chart review was carried out for all patients with endometrial cancer managed at Parma University Hospital Unit of Gynecology and Obstetrics between 2010 and 2016. Inclusion criteria were surgical procedure including hysterectomy and lymphadenectomy (pelvic or pelvic and aortic). Read More

Colorectal Dis 2019 Jan 17. Epub 2019 Jan 17.

Colorectal Service, Department of General Surgery, Tan Tock Seng Hospital, Singapore.

J Surg Case Rep 2019 Jan 9;2019(1):rjy343. Epub 2019 Jan 9.

Department of Gynecologic Oncology, Private Adatıp Sakarya Hospital, Sakarya, İstiklal District, Şehit Mehmet Karabaşoğlu Street, No:67, Serdivan, Turkey.

The femoral vein is named as external iliac vein as it progresses in the cranial direction. In the current case report, a rare variation of the left external iliac vein that was found incidentally during pelvic lymph node dissection in a 36-year-old woman is presented. We also found the same variation at the right side in a 55-year-old woman during laparoscopic pelvic lymph node dissection. Read More

Nat Rev Urol 2019 Jan 15. Epub 2019 Jan 15.

Martini Klinik, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

One of the challenges for the surgical management of prostate cancer is the lymphatic spread of metastases. Lymph node metastases vary in size (micrometastases (<2 mm) or macrometastases (>2 mm)), and their interactions with the lymphatic environment differ (whether they are hypoxic or connected to blood flow). Thus, devising a universal imaging system and an image-guided surgical approach that supports the resection of all affected lymph nodes is difficult. Read More

Int J Gynecol Cancer 2019 Jan;29(1):86-93

Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet and Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.

Background And Objectives: In the Robot Assisted Surgery for High Risk Endometrial Cancer (RASHEC) trial, patients with high-risk endometrial cancer were randomly assigned to robot-assisted laparoscopic surgery (RALS) or laparotomy for pelvic and infrarenal para-aortic lymph node dissection. We here report on self-reported lower limb lymphedema (LLL), lymphocyst formation, ascites, and long-term serious adverse events 12 months after surgery.

Patients And Methods: Patients were enrolled between 2013 and 2016, and 96 patients were included in the per protocol analysis, evenly distributed between RALS and laparotomy. Read More

Int J Gynecol Cancer 2019 Jan;29(1):53-59

Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

Objective: To identify factors that affect successful adaptation of sentinel lymph node mapping and those that lead to unintended adipose-only sentinel lymph node identification.

Methods: Surgical and pathological data were prospectively collected on patients with endometrial cancer who underwent sentinel lymph node mapping with indocyanine green with or without pelvic and/or para-aortic lymph node dissection between November 2013 and April 2017. All mapping cases were performed with the robotic system. Read More

J Urol 2019 02;201(2):226-227

Surg Res Pract 2018 2;2018:9162921. Epub 2018 Dec 2.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.

Background: An objective of this study was to determine the prognostic role of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients with cervical cancer (CC) stages IA2-IB1.

Methods: The study included 484 patients who underwent radical hysterectomy with pelvic node dissection. The associations of preoperative NLR and PLR with clinicopathologic characteristics and oncological outcomes were analyzed. Read More

Hernia 2019 Jan 9. Epub 2019 Jan 9.

Department of Surgery, JA Sapporo Kosei Hospital, N3, E8, Chuo-ku, Sapporo, 060-0033, Japan.

Purpose: Lateral lymph node dissection (LLND) is performed for advanced lower rectal cancer (ALRC) in Japan. The LLND in laparotomy is performed via the extraperitoneal approach, which is similar to radical retropubic prostatectomy (RRP). Inguinal hernias (IHs) appearing after RRP are common. Read More

Int J Gynecol Cancer 2019 Jan 4. Epub 2019 Jan 4.

Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objectives: Superficially invasive stage IA squamous vulvar cancer (VSCC) is defined as a single lesion measuring ≤2 cm with a depth of invasion of ≤1.0 mm (FIGO stage IA). This article examines the natural course and prognosis of superficially invasive VSCC. Read More

BMC Urol 2019 Jan 5;19(1). Epub 2019 Jan 5.

Faculty of Medicine, Department of Biostatistics, Cukurova University, Adana, Turkey.

Background: Optimal treatment of high-risk prostate cancer remains controversial. We aimed to compare treatment outcomes of prostate cancer patients treated with definitive external-beam radiotherapy (ExRT) or radical prostatectomy (RP).

Methods: The records of 120 high-risk clinical stage T2b-T4 N0 M0 prostate cancer patients treated with definitive ExRT or RP were reviewed. Read More

Histopathology 2019 Jan 3. Epub 2019 Jan 3.

University Health Network, University of Toronto, Toronto, Canada.

Introduction: Pathologic evaluation of lymphadenectomy specimens plays a pivotal role in accurate lymph node (LN) staging. Guidelines standardizing the gross handling and reporting of pelvic LN dissection (PLND) in prostate (PCa) and bladder (BCa) cancer are currently lacking. This study aimed to establish current practice patterns of PLND evaluation among pathologists. Read More

Scand J Urol 2018 Dec 26:1-8. Epub 2018 Dec 26.

l Department of Molecular Medicine and Surgery , Karolinska Institutet , Stockholm , Sweden.

Objective: To describe study design and procedures for a prospective randomized trial investigating whether radical prostatectomy (RP) ± radiation improves cause-specific survival in comparison with primary radiation treatment (RT) and androgen deprivation treatment (ADT) in patients with locally advanced prostate cancer (LAPC).

Materials And Methods: SPCG-15 is a prospective, multi-centre, open randomized phase III trial. Patients are randomized to either standard (RT + ADT) or experimental (RP with extended pelvic lymph-node dissection and with addition of adjuvant or salvage RT and/or ADT if deemed necessary) treatment. Read More

Zhonghua Fu Chan Ke Za Zhi 2018 Dec;53(12):811-815

Department of Pathology, Peking University People's Hospital, Beijing 100044, China.

To assess the clinical value for the clinicopathological features of microcystic elongated and fragmented (MELF) invasion in endometrial carcinoma (EEC) . The clinicopathological data of 108 cases of endometrial carcinoma with total hysterectomy, bilateral adnexectomy, and pelvic dissection were retrospectively analysis in Peking University People's Hospital from April 2015 to October 2016. Twenty-five patients with endometrial carcinoma showing MELF invasion pattern were collected. Read More

Front Surg 2018 7;5:74. Epub 2018 Dec 7.

Urology Department, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.

Lymph node metastases (LNM) represent a proven prognostic factor for biochemical recurrence (BCR)-free survival, metastatic free survival and overall survival in prostate cancer (PCa). Although pelvic node dissection remains the gold standard for the detection of LNM, novel imaging techniques are entering clinical practice, in the effort to improve LNM detection and spare unnecessary surgeries. Aim of the current review is to describe such imaging techniques and explore their advantages and limitations. Read More

Urol Oncol 2019 Mar 19;37(3):219-226. Epub 2018 Dec 19.

The Smith Institute for Urology, Zucker School of Medicine Hofstra/Northwell, New Hyde Park, NY. Electronic address:

Lymph node dissection is part of the standard treatment protocol for various cancers, but its role in prostate cancer has been debatable for some time. Pelvic lymphadenectomy has been shown to better help stage prostate cancer patients, but has yet to be definitively proven to be of any benefit for survival. Various templates for lymph node dissections exist, and though some national guidelines have endorsed an extended pelvic node dissection, the choice of template is still controversial. Read More

Surg J (N Y) 2018 Oct 28;4(4):e226-e234. Epub 2018 Nov 28.

Department of Urology, The Mater Misericordiae University Hospital, Eccles Street, Dublin, Ireland.

 There is a little published data on the outcomes of radical prostatectomy in the Irish context. We aimed to determine the 5-year oncological results of open radical retropubic prostatectomy (RRP) performed by a single surgeon following appointment.  A retrospective review of RRPs performed between 2011 and 2016 was conducted. Read More

Pan Afr Med J 2018 16;30:208. Epub 2018 Jul 16.

Service de Radiothérapie, CHU Hassan II Fès, Maroc.

In this paper, we report a case of primary squamous cell carcinoma of the endometrium (PSCCE) with a literature review. A 64-year-old woman was admitted because of postmenopausal bleeding. The gynecological exam found bleeding from the endocervix. Read More

Int J Surg Case Rep 2018 13;53:394-396. Epub 2018 Nov 13.

TC Ministry of Health, Health Sciences University, Gazi Yaşargil Diyarbakır Training and Research Hospital, Obstetrics and Gynecology, Diyarbakir, Turkey. Electronic address:

Introduction: Obturator nerve is barely injured during gynecological surgeries. The risk for obturator nerve injury is increased during pelvic lymphadenectomy procedures of gynecological malignancies. In case of any obturator nerve injury, surgical management involve laparoscopic approaches suchas end-to-end anastomosis in very early period. Read More

Eur J Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Centre de recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM) and Institut du cancer de Montréal, Montréal, Québec, Canada.

Purpose: To analyze lymph node invasion (LNI) rates according to tumor characteristics and to test the impact of LNI and its extent on cancer specific mortality (CSM) in surgically-treated non metastatic urothelial upper urinary tract carcinoma (UTUC) patients.

Materials And Methods: Within the SEER database (2004-2014), we identified 2098 patients with histologically confirmed non-metastatic urothelial carcinoma of renal pelvis or ureter who underwent NU with LND. LNI rates stratified according to tumor location and stage were described. Read More

JMIR Res Protoc 2018 Dec 13;7(12):e11256. Epub 2018 Dec 13.

Department of Radiation Oncology, University Hospitals Leuven, University of Leuven, Leuven, Belgium.

Background: In patients with prostate cancer (PCa) with histopathologically proven pelvic lymph node (LN) metastasis (pN1) after extended pelvic lymph node dissection (ePLND), multimodality treatment consisting of treatment of the primary tumor and whole pelvic radiotherapy (WPRT) combined with androgen deprivation therapy (ADT) offers promising results, leading to better cause-specific survival rates compared with ADT alone. However, in case more than one pelvic LN is invaded by the tumor, approximately 40% of the patients relapse biochemically and clinically. Clinical relapse is present in the para-aortic LNs (M1a disease) in up to 77% of the relapsing cases. Read More

Hinyokika Kiyo 2018 Nov;64(11):455-458

The Department of Pathology, National Hospital Organization Osaka Minami Medical Center.

A 75-year-old man with a history of early gastric cancer, phimosis and bronchial asthma experienced pain and palpated a mass in the penis in March 2015. After 2 months, he noticed bleeding from the tumor and visited our hospital. Pelvic computed tomography and magnetic resonance imaging revealed a pelvic tumor, bilateral lymphadenopathy, and para-aortic lymphadenopathy. Read More

World J Oncol 2018 Nov 23;9(5-6):145-150. Epub 2018 Nov 23.

Department of Urology, Gauhati Medical College Hospital, Guwahati, Assam, India.

Background: Penile cancer is a rare malignancy. The extent of lymph node (LN) metastasis is the most important prognostic factor in penile cancer. However, preoperative prediction of LN involvement in clinically non-palpable LN is still a challenge. Read More

Urol Oncol 2018 12 24;36(12):530.e7-530.e18. Epub 2018 Oct 24.

Department of Pathology and Department of Clinical and Experimental Medicine, Medical Faculty, Linköping University, SE 581 85, Linköping, Sweden.

Purpose: We investigated the effects of alterations in the biological markers p14, p53, p21, and p16 in relation to tumour cell proliferation, T-category, N- category, lymphovascular invasion, and the ability to predict prognosis in patients with muscle-invasive bladder cancer (MIBC) treated with cystectomy and, if applicable, chemotherapy.

Materials And Methods: We prospectively studied patients with urinary bladder cancer pathological stage pT1 to pT4 treated with cystectomy, pelvic lymph node dissection and postoperative chemotherapy. Tissue microarrays from paraffin-embedded cystectomy tumour samples were examined for expression of immunostaining of p14, p53, p21, p16 and Ki-67 in relation to other clinical and pathological factors as well as cancer-specific survival. Read More

BMC Res Notes 2018 Dec 7;11(1):871. Epub 2018 Dec 7.

Department of Urology, Odense University Hospital, Odense, Denmark.

Objective: This proof of concept study investigated whether dual time point FDG-PET/CT with image acquisition after 1 and 3 h could be useful in preoperative staging of patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection for high-risk prostate cancer.

Results: Twenty patients with high-risk prostate cancer underwent dual time point FDG-PET/CT before undergoing surgery. Histologically confirmed lymph node metastases were found in 9/20 (45%). Read More

Eur Urol 2018 Nov 28. Epub 2018 Nov 28.

Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium. Electronic address:

Background: Patients with biochemical recurrence following primary prostate cancer (PCa) treatment often experience relapse in the lymph nodes (LNs). Both salvage LN dissection (sLND) and elective nodal radiotherapy (ENRT) are potential treatment options.

Objective: To describe anatomic patterns of nodal oligorecurrent PCa in relation to different surgical and radiotherapy templates. Read More

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Departments of Obstetrics and Gynecology (N.I., Y.F., T.S., A.K., T.O., F.K.) Pathology (Y. Ikura, Y. Iwai) Hematology (M.O.), Takatsuki General Hospital, Takatsuki, Japan.

Primary ovarian lymphomas are rare, but can potentially evoke diagnostic problems. We present a case of ovarian lymphoma, in which an ambiguous intraoperative pathologic report led to overtreatment (unnecessary surgery). A 73-yr-old woman with fatigue and low-grade fever was diagnosed as having a left ovarian tumor by imaging modalities. Read More

Eur Urol 2018 Nov 30. Epub 2018 Nov 30.

Department of Urology, University of Verona, Verona, Italy.

Background: The Vescica Ileale Padovana (VIP) was first described in 1989 as a technique for total bladder replacement, and gained popularity due to technical simplicity and functional advantages.

Objective: To report preliminary results and a detailed step-by-step surgical technique description of robot-assisted VIP (ra-VIP) that replicates the open technique principles.

Design, Setting, And Participants: We report the data of 15 consecutive patients who underwent robot-assisted radical cystectomy (RARC) and totally intracorporeal ra-VIP at our institution from April 2015 to March 2017. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13418

Department of Gynecology.

Rationale: Primary squamous cell carcinoma of the endometrium (PSCCE) is a rare entity, and only sporadic cases have been reported in the literature since the 1st report in 1892. This report describes a case of a perimenopausal woman with PSCCE.

Patient Concerns: A 47-year-old, human papilloma virus type 16-positive, perimenopausal woman was admitted to our hospital with irregular vaginal bleeding for 6 months and secondary anemia. Read More

Arch Gynecol Obstet 2018 Nov 28. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Sahlgrenska Academy at University of Gothenburg, 41345, Gothenburg, Sweden.

Purpose: Our aim was to evaluate fertility-sparing surgery of early stage cervical cancer after the introduction of vaginal trachelectomy (VT) and pelvic lymph node dissection (PLND). The objectives were to assess surgical, long-term oncological, fertility, and obstetric outcomes together with self-assessed quality of life (QoL).

Methods: All women ≤ 40 years diagnosed with early stage cervical cancers IA1-IB1 and ≤ 2 cm treated by VT and PLND between 2000 and 2014 were included. Read More

J Endourol 2019 Jan 31. Epub 2019 Jan 31.

1 Departments of Urology, Italy.

Objective: To determinate benefits of the combination of local anesthetic wounds infiltration and ultrasound transversus abdominal plane (US-TAP) block with ropivacaine on postoperative pain, early recovery, and hospital stay in patients undergoing robot-assisted radical prostatectomy (RARP).

Methods: The study is double-blinded randomized controlled trial. Our hypothesis was that the combination of wound infiltration and US-TAP block with ropivacaine would decrease immediate postoperative pain and opioids use. Read More