12,808 results match your criteria Lyme Disease


Characteristics and clinical outcomes after treatment of a national cohort of PCR-positive Lyme arthritis.

Semin Arthritis Rheum 2018 Sep 28. Epub 2018 Sep 28.

EA 7290-Virulence bactérienne précoce, groupe borréliose de Lyme, CHRU de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France; Centre National de Référence des Borrelia, CHRU Strasbourg, France.

Objectives: To describe the clinical and microbiological characteristics and outcomes after antibiotic treatment of a national cohort of patients with Lyme arthritis confirmed by PCR testing on synovial fluid and by serology, when available.

Methods: Using the French National Reference Center for Borrelia database, patients with a positive PCR on synovial fluid for Borrelia were identified. Patient clinical and biological characteristics were reviewed from patient records. Read More

View Article
September 2018

Evaluation of in vivo expressed Borrelia burgdorferi antigens for improved IgM serodiagnosis of early Lyme disease.

Diagn Microbiol Infect Dis 2018 Oct 3. Epub 2018 Oct 3.

Division of Vector Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States of America. Electronic address:

Improved serologic tests are needed for accurate diagnosis and proper treatment of early stage Lyme disease. We evaluated the 3 antigens currently used for 2-tiered IgM immunoblot testing (FlaB, OspC, and BmpA) in combination with 3 additional antigens (BBA65, BBA70, and BBA73) and measured the sensitivity and specificity against a serum repository of positive and negative controls. Using 3 statistical methods for positivity cutoff determinations and scoring criteria, we found increased sensitivities for early Lyme disease when 2 of 6 antigens were positive as compared with the 2 of 3 antigen IgM criteria currently used for second-tier immunoblot scoring. Read More

View Article
October 2018

Using volunteered observations to map human exposure to ticks.

Sci Rep 2018 Oct 18;8(1):15435. Epub 2018 Oct 18.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Lyme borreliosis (LB) is the most prevalent tick-borne disease in Europe and its incidence has steadily increased over the last two decades. In the Netherlands alone, more than 20,000 citizens are affected by LB each year. Because of this, two Dutch citizen science projects were started to monitor tick bites. Read More

View Article
October 2018

Identification of Essential Oils with Strong Activity against Stationary Phase .

Antibiotics (Basel) 2018 Oct 16;7(4). Epub 2018 Oct 16.

Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

Lyme disease is the most common vector borne-disease in the United States (US). While the majority of the Lyme disease patients can be cured with 2⁻4 weeks antibiotic treatment, about 10⁻20% of patients continue to suffer from persisting symptoms. While the cause of this condition is unclear, persistent infection was proposed as one possibility. Read More

View Article
October 2018
1 Read

[Late Neuroborreliosis in an Erasmus Programme Student].

Acta Med Port 2018 Sep 28;31(9):509-511. Epub 2018 Sep 28.

Serviço de Doenças Infecciosas. Centro Hospitalar do Porto, EPE. Porto, Portugal.

Lyme disease is an endemic zoonosis, the most prevalent tick-transmitted infection in temperate areas of Europe, North America and Asia. It is a multisystemic disease with cutaneous, musculoskeletal, neurologic and cardiac manifestations, according to the stage of the disease. We describe a case of late neuroborreliosis in an Erasmus programme student living in Porto. Read More

View Article
September 2018

Current Status of Tick-Borne Diseases in South Korea.

Vector Borne Zoonotic Dis 2018 Oct 17. Epub 2018 Oct 17.

1 Department of Internal Medicine and Inha University School of Medicine , Incheon, Republic of Korea.

Background: Bites with tick-borne pathogens can cause various bacterial, viral, or parasitic diseases in humans. Tick-transmitted diseases are known as contributing factors to the increasing incidence and burden of diseases. The present article investigated the epidemiology of tick-borne diseases in South Korea. Read More

View Article
October 2018

Rickettsiales Occurrence and Co-occurrence in Ixodes ricinus Ticks in Natural and Urban Areas.

Microb Ecol 2018 Oct 16. Epub 2018 Oct 16.

Department of Parasitology, Institute of Zoology, Faculty of Biology, University of Warsaw, 1 Miecznikowa Street, 02-096, Warszawa, Poland.

Bacteria of Rickettsiaceae and Anaplasmataceae families include disease agents spread by Ixodes ricinus ticks, the most common tick vector in Europe. The aim of the study was to compare the prevalence and co-infection prevalence of particular tick-transmitted Rickettsiales members: Rickettsia spp. (further referred as Rs), Anaplasma phagocytophilum (Ap), and "Candidatus Neoehrlichia mikurensis" (CNM) in I. Read More

View Article
October 2018
1 Read

Characterization of recombinant OspA in two different Borrelia vaccines with respect to immunological response and its relationship to functional parameters.

BMC Vet Res 2018 Oct 16;14(1):312. Epub 2018 Oct 16.

Merial Inc., Boehringer Ingelheim, Athens, GA, USA.

Background: Prevention of Lyme disease in dogs in North America depends on effective vaccination against infection by the tick vector-born spirochete Borrelia burgdorferi. Most vaccines effectively prevent spirochete transmission to dogs during tick feeding based on immunization with the outer-surface lipoprotein A (OspA) of B. burgdorferi. Read More

View Article
October 2018
2 Reads

Under-Detection of Lyme Disease in Canada.

Healthcare (Basel) 2018 Oct 15;6(4). Epub 2018 Oct 15.

Division of General Internal Medicine, University of Calgary, South Health Campus, Calgary, AB T3M 1M4, Canada.

Lyme disease arises from infection with pathogenic species. In Canada, current case definition for confirmed Lyme disease requires serological confirmation by both a positive first tier ELISA and confirmatory second tier immunoblot (western blot). For surveillance and research initiatives, this requirement is intentionally conservative to exclude false positive results. Read More

View Article
October 2018
10 Reads

Tick Bite-Associated Morphea: A Case Report.

Am J Dermatopathol 2018 Oct 9. Epub 2018 Oct 9.

Department of Dermatology, University of Florida College of Medicine, Gainesville, FL.

Borrelia burgdorferi, the causative organism of Lyme disease, has been linked to the development of scleroatrophic skin conditions including morphea, although this association remains controversial. The possibility that tick bite with or without concurrent Borrelia infection instigates that morphea development is important to recognize because this could prompt further workup for Lyme disease, or other tick-borne illness, which, when untreated, can have devastating consequences. Here, we report a case of a woman with a history of previous tick bite in the location of morphea. Read More

View Article
October 2018
1 Read

Removing the Mask of Average Treatment Effects in Chronic Lyme Disease Research Using Big Data and Subgroup Analysis.

Healthcare (Basel) 2018 Oct 12;6(4). Epub 2018 Oct 12.

Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA.

Lyme disease is caused by the bacteria borrelia burgdorferi and is spread primarily through the bite of a tick. There is considerable uncertainty in the medical community regarding the best approach to treating patients with Lyme disease who do not respond fully to short-term antibiotic therapy. These patients have persistent Lyme disease symptoms resulting from lack of treatment, under-treatment, or lack of response to their antibiotic treatment protocol. Read More

View Article
October 2018
1 Read

Characterization of fluorescent proteins, promoters, and selectable markers for applications in the Lyme disease spirochete .

Appl Environ Microbiol 2018 Oct 12. Epub 2018 Oct 12.

Microbial Sciences Institute, Yale West Campus, West Haven, Connecticut, USA.

Lyme disease is the most widely reported vector-borne disease in the United States. Its incidence is rapidly increasing and disease symptoms can be debilitating. The need to understand the biology of the disease agent, the spirochete , is thus evermore pressing. Read More

View Article
October 2018
4 Reads

Distribution of in Northwestern Ontario: Results from Active and Passive Surveillance Activities in the Northwestern Health Unit Catchment Area.

Int J Environ Res Public Health 2018 Oct 11;15(10). Epub 2018 Oct 11.

Northwestern Health Unit, Kenora, ON P9N 2K4, Canada.

The range of is expanding in Ontario, increasing the risk of Lyme disease. As an effective public health response requires accurate information on disease distribution and areas of risk, this study aims to establish the geographic distribution of and its associated pathogen, , in northwestern Ontario. We assessed five years of active and passive tick surveillance data in northwestern Ontario. Read More

View Article
October 2018
3 Reads

Direct Diagnostic Tests for Lyme Disease.

Clin Infect Dis 2018 Oct 11. Epub 2018 Oct 11.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston.

Borrelia burgdorferi was discovered to be the cause of Lyme disease in 1983, leading to seroassays. The 1994 serodiagnostic testing guidelines predated a full understanding of key B. burgdorferi antigens and have a number of shortcomings. Read More

View Article
October 2018
15 Reads
8.89 Impact Factor

Insects and the Transmission of Bacterial Agents.

Microbiol Spectr 2018 Oct;6(5)

Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France.

Arthropods are small invertebrate animals, among which some species are hematophagous. It is during their blood meal that they can transmit pathogenic microorganisms that they may be harboring to the vertebrate host that they parasitize, which in turn will potentially develop a vector-borne disease. The transmission may occur directly through their bite, but also through contaminated feces. Read More

View Article
October 2018
3 Reads

A tetratricopeptide repeat domain protein has profound effects on assembly of periplasmic flagella, morphology and motility of the lyme disease spirochete Borrelia burgdorferi.

Mol Microbiol 2018 Oct 10. Epub 2018 Oct 10.

Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.

Spirochetes possess a unique periplasmic flagellar motor component called the collar. However, little is known about the composition or function of the flagellar collar proteins. To identify a collar protein, we have inactivated almost all genes annotated as motility-related in the Borrelia burgdorferi genome and identified only FlbB, which comprises the base of the collar. Read More

View Article
October 2018
3 Reads
4.42 Impact Factor

Incidence of notified Lyme borreliosis in Germany, 2013-2017.

Sci Rep 2018 Oct 8;8(1):14976. Epub 2018 Oct 8.

Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.

Lyme borreliosis (LB) is the most commonly reported tick-borne disease in Germany. In 9/16 states, notification of erythema migrans (EM), acute neuroborreliosis (NB) and Lyme arthritis (LA) is mandatory. We describe incidence measures, time trends, geographical distribution and frequencies of manifestations to better understand LB epidemiology and target prevention measures. Read More

View Article
October 2018
2 Reads

Teaching NeuroImages: Lyme disease presenting as Bannwarth syndrome.

Neurology 2018 Oct;91(15):e1459-e1460

From the Department of Neurology, West Virginia University, Morgantown.

View Article
October 2018
2 Reads

Woman with lower back pain, SIADH and a twist of Lyme.

BMJ Case Rep 2018 Oct 7;2018. Epub 2018 Oct 7.

Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

A 62-year-old woman was admitted with a 3-week history of atraumatic bilateral lower back pain, progressive ascending flaccid paralysis, hyponatraemia and constipation. She was otherwise in good health with only a recent diagnosis of acute gastroenteritis that preceded her presenting symptoms. Her initial laboratory evaluation was consistent with Syndrome of Inappropriate Antidiuretic Hormone (SIADH) but was otherwise unremarkable. Read More

View Article
October 2018
2 Reads

Recent strategies for the diagnosis of early Lyme disease.

Authors:

Sci Prog 2018 Oct 8. Epub 2018 Oct 8.

View Article
October 2018
2 Reads

Role of body composition and physical activity on permethrin urinary biomarker concentrations while wearing treated military uniforms.

Toxicol Lett 2018 Oct 5;299:210-217. Epub 2018 Oct 5.

Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, 4770 Buford Hwy, Atlanta, GA, USA.

Wearing of permethrin treated clothing is becoming more prevalent in military and outdoor occupational and recreational settings, as a personal protection measure against vector borne diseases transmitted through arthropods (e.g., malaria, Lyme disease). Read More

View Article
October 2018
6 Reads

Relapsing fever in California: a pilot serological study.

Int J Gen Med 2018 21;11:373-382. Epub 2018 Sep 21.

Union Square Medical Associates, San Francisco, CA, USA,

Background: spirochetes are tick-borne Gram-negative bacteria that cause disease in humans and animals. Although many studies have focused on (Bb), the agent of Lyme disease, recent studies have examined the role of Relapsing Fever (RFB) in human disease. In this pilot study, we have evaluated serological reactivity against Bb and RFB in patients residing in California. Read More

View Article
September 2018
4 Reads

Impact of pre-existing treatment with statins on the course and outcome of tick-borne encephalitis.

PLoS One 2018 4;13(10):e0204773. Epub 2018 Oct 4.

Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.

Objectives: Although statins have anti-inflammatory and potentially also antimicrobial (including antiviral) activity, their therapeutic impact on infectious diseases is controversial. In this study, we evaluated whether pre-existing statin use influenced the course and outcome of tick-borne encephalitis.

Methods: To assess the influence of statin usage on the severity of acute illness and the outcome of tick-borne encephalitis, univariate and multivariable analyses were performed for 700 adult patients with tick-borne encephalitis of whom 77 (11%) were being treated with statins, and for 410 patients of whom 53 (13%) were receiving statins, respectively. Read More

View Article
October 2018
3 Reads

N-acetylmannosamine (ManNAc) supports the growth of Borrelia burgdorferi in the absence of N-acetylglucosamine (GlcNAc).

FEMS Microbiol Lett 2018 Oct 3. Epub 2018 Oct 3.

Department of Biology and Marine Biology, University of North Carolina, Wilmington 601 South College Road, Wilmington, NC 28403, USA.

Borrelia burgdorferi, the causative agent of Lyme disease, lacks the ability to biosynthesize many essential nutrients de novo, including N-acetylglucosamine (GlcNAc). This amino sugar is required for cell wall synthesis, and is a component of the complex growth medium used for in vitro propagation. When cultured without free GlcNAc B. Read More

View Article
October 2018
2 Reads

Lyme disease: diagnosis and management.

Pract Neurol 2018 Oct 3. Epub 2018 Oct 3.

Neurology Department, Wessex Neurosciences Centre, Southampton General Hospital, Tremona Road, Southampton, UK.

Lyme disease (borreliosis) is a tick-borne bacterial infection caused by the spirochaete , transmitted by hard-backed ticks. Actual numbers of cases are increasing and it appears that the distribution across the UK is widening; however, it occurs most frequently in area of woodland, with temperate climate. It typically presents in mid to late summer. Read More

View Article
October 2018
2 Reads

Frontotemporal Dementia Misdiagnosed for Post-Treatment Lyme Disease Syndrome or vice versa? A Treviso Dementia (TREDEM) Registry Case Report.

J Alzheimers Dis 2018 Sep 28. Epub 2018 Sep 28.

Cognitive Impairment Center, Local Health Autority n.2 Marca Trevigiana, Treviso, Italy.

We describe the case of a 61-year-old woman diagnosed with Borreliosis at the age of 57. Subsequently, the patient developed depression, anxiety, and behavioral disturbances. A lumbar puncture excluded the condition of Neuroborreliosis. Read More

View Article
September 2018
2 Reads

Reversible atrioventricular block and the importance of close follow-up: Two cases of Lyme carditis.

J Cardiol Cases 2018 May 13;17(5):171-174. Epub 2018 Feb 13.

United Health Services Hospitals, Wilson Regional Medical Center, Department of Cardiology, 30 Harrison St #250, Johnson City, NY, USA.

Lyme carditis is an uncommon presentation of the early-disseminated phase of Lyme disease, although it is recognizable and often curable. Because of its rarity, diagnosing Lyme carditis requires a high level of suspicion, especially when young patients in certain endemic areas present with symptoms of bradycardia and/or evidence of high-degree atrioventricular (AV) block. Temporary cardiac pacing along with antibiotic therapy has been shown to aid in the management of Lyme carditis until symptoms and conduction blocks have resolved. Read More

View Article
May 2018
2 Reads

The Presence of Bull's Eye Lesion Is Not Required to Diagnose Lyme Disease.

Authors:
Marjorie Bowman

Am Fam Physician 2018 Oct;98(8):474

Kettering, OH, USA.

View Article
October 2018
1 Read

Assessment of the Public Health Threats Posed by Vector-Borne Disease in the United Kingdom (UK).

Int J Environ Res Public Health 2018 Sep 29;15(10). Epub 2018 Sep 29.

Medical Entomology Group, Public Health England, Emergency Response Department, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.

In recent years, the known distribution of vector-borne diseases in Europe has changed, with much new information also available now on the status of vectors in the United Kingdom (UK). For example, in 2016, the UK reported their first detection of the non-native mosquito , which is a known vector for dengue and chikungunya virus. In 2010, , a principal mosquito vector for West Nile virus was detected in large numbers in the Thames estuary. Read More

View Article
September 2018
2 Reads

Neuroborreliosis and Neurosyphilis.

Authors:
John J Halperin

Continuum (Minneap Minn) 2018 Oct;24(5, Neuroinfectious Disease):1439-1458

Purpose Of Review: This article presents an overview of the current diagnosis and management of two spirochetal infections of the nervous system, neuroborreliosis (Lyme disease) and neurosyphilis, focusing on similarities and differences. Although neuroborreliosis was first identified almost a century ago, much confusion remains about how to accurately diagnose this quite treatable nervous system infection. Well-established diagnostic tools and therapeutic regimens exist for neurosyphilis, which has been well-known for centuries. Read More

View Article
October 2018
5 Reads

Travel and tick-borne diseases: Lyme disease and beyond.

Travel Med Infect Dis 2018 Sep 26. Epub 2018 Sep 26.

Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

View Article
September 2018
4 Reads

Diagnosis of a tick-borne coinfection in a patient with persistent symptoms following treatment for Lyme disease.

BMJ Case Rep 2018 Sep 27;2018. Epub 2018 Sep 27.

Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

A 67-year-old woman presented with 5 days of myalgias and fevers on completion of a 21-day course of amoxicillin for Lyme disease ( infection). She was found to have profound thrombocytopenia, as well as new anaemia and leucopenia. Workup revealed as the causative agent of her symptoms. Read More

View Article
September 2018
5 Reads

Large-scale health disparities associated with Lyme disease and human monocytic ehrlichiosis in the United States, 2007-2013.

PLoS One 2018 27;13(9):e0204609. Epub 2018 Sep 27.

Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado, United States of America.

Promoting health equity is a fundamental public health objective, yet health disparities remain largely overlooked in studies of vectorborne diseases, especially those transmitted by ticks. We sought to identify health disparities associated with Lyme disease and human monocytic ehrlichiosis, two of the most pervasive tickborne diseases within the United States. We used general linear mixed models to measure associations between county-level disease incidence and six variables representing racial/ethnic and socioeconomic characteristics of counties (percent white non-Hispanic; percent with a bachelors degree or higher; percent living below the poverty line; percent unemployed; percent of housing units vacant; per capita number of property crimes). Read More

View Article
September 2018
1 Read

A Serological Survey of Borrelia burgdorferi Infection in Sheep in Northeast China Regions Through Outer Surface Protein C-Based Enzyme-Linked Immunosorbent Assay.

Vector Borne Zoonotic Dis 2018 Sep 27. Epub 2018 Sep 27.

1 College of Veterinary Medicine, Northeast Agricultural University , Harbin, China .

Borrelia burgdorferi as a causative agent of Lyme disease is transmitted by Ixodes spp. ticks to humans and animals. Sheep is considered a natural reservoir for B. Read More

View Article
September 2018
1 Read

Limitations and Confusing Aspects of Diagnostic Testing for Neurologic Lyme Disease in the United States.

J Clin Microbiol 2018 Sep 26. Epub 2018 Sep 26.

Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595

In the United States, laboratories frequently offer multiple different assays for testing of cerebrospinal fluid (CSF) samples to provide laboratory support for the diagnosis of central nervous system Lyme disease (CNSLD). Often included among these diagnostic tests are the same enzyme immunoassays and immunoblots that are routinely used to detect the presence of antibodies to in serum. However, performing these assays on CSF alone may yield positive results simply from passive diffusion of serum antibodies into the CSF. Read More

View Article
September 2018
1 Read

In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease.

Drug Des Devel Ther 2018 11;12:2915-2921. Epub 2018 Sep 11.

Biomaterials and Advanced Drug Delivery, Stanford Cardiovascular Pharmacology Division, Cardiovascular Institute, School of Medicine, Stanford University, Palo Alto, CA, USA,

Background: Lyme disease accounts for >90% of all vector-borne disease cases in the United States and affect ~300,000 persons annually in North America. Though traditional tetracycline antibiotic therapy is generally prescribed for Lyme disease, still 10%-20% of patients treated with current antibiotic therapy still show lingering symptoms.

Methods: In order to identify new drugs, we have evaluated four cephalosporins as a therapeutic alternative to commonly used antibiotics for the treatment of Lyme disease by using microdilution techniques like minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). Read More

View Article
September 2018
3 Reads

Tritrophic interactions between a fungal pathogen, a spider predator, and the blacklegged tick.

Ecol Evol 2018 Aug 13;8(16):7824-7834. Epub 2018 Jul 13.

Cary Institute of Ecosystem Studies Millbrook New York.

The blacklegged tick is the primary vector for the bacterium causing Lyme disease in eastern North America and for other medically important pathogens. This species is vulnerable to attack by fungal pathogens and arthropod predators, but the impacts of interactions between biocontrol agents have not been examined. The biocontrol agent Met52, containing the entomopathogenic fungus (=), controls blacklegged ticks with efficacy comparable to chemical acaricides. Read More

View Article
August 2018
1 Read

DNA Methylation by Restriction Modification Systems Affects the Global Transcriptome Profile in

J Bacteriol 2018 Sep 24. Epub 2018 Sep 24.

Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58202-9061, USA.

Prokaryote restriction modification (RM) systems serve to protect bacteria from potentially detrimental foreign DNA. Recent evidence suggests that DNA methylation by the methyltransferase (MTase) components of RM systems can also have effects on transcriptome profiles. The type strain of causative agent of Lyme disease, B31 possesses two RM systems with N6-methyladenosine (m6A) MTase activity; encoded by the gene located on linear plasmid lp25, and on lp56. Read More

View Article
September 2018
2 Reads

Systematic Approach to the Diagnosis and Treatment of Lyme Carditis and High-Degree Atrioventricular Block.

Healthcare (Basel) 2018 Sep 22;6(4). Epub 2018 Sep 22.

Department of Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.

Lyme carditis (LC) is a manifestation of the early disseminated stage of Lyme disease and often presents as high-degree atrioventricular (AV) block. High-degree AV block in LC can be treated with antibiotics, usually resolving with a highly favorable prognosis, thus preventing the unnecessary implantation of permanent pacemakers. We present a systematic approach to the diagnosis and management of LC that implements the Suspicious Index in Lyme Carditis (SILC) risk stratification score. Read More

View Article
September 2018
1 Read

Dogs () as Sentinels for Human Infectious Disease and Application to Canadian Populations: A Systematic Review.

Vet Sci 2018 Sep 21;5(4). Epub 2018 Sep 21.

The Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Roslin EH25 9RG, UK.

In a world where climate change, vector expansion, human activity, and pathogen dispersal do not respect boundaries, the human⁻animal⁻pathogen interface has become less defined. Consequently, a One Health approach to disease surveillance and control has generated much interest across several disciplines. This systematic review evaluates current global research on the use of domestic dogs as sentinels for human infectious disease, and critically appraises how this may be applied within Canada. Read More

View Article
September 2018
1 Read

Impacts of misclassification on Lyme disease surveillance.

Zoonoses Public Health 2018 Sep 21. Epub 2018 Sep 21.

Emerging Infections Program, Maryland Department of Health, Baltimore, Maryland.

In Maryland, Lyme disease (LD) is the most widely reported tickborne disease. All laboratories and healthcare providers are required to report LD cases to the local health department. Given the large volume of LD reports, the nuances of diagnosing and reporting LD, and the effort required for investigations by local health department staff, surveillance for LD is burdensome and subject to underreporting. Read More

View Article
September 2018
9 Reads

Genome-wide analysis of Borrelia turcica and 'Candidatus Borrelia tachyglossi' shows relapsing fever-like genomes with unique genomic links to Lyme disease Borrelia.

Infect Genet Evol 2018 Sep 18;66:72-81. Epub 2018 Sep 18.

The Vector and Water-Borne Pathogen Research Group, The School of Veterinary and Life Sciences, Murdoch University, Perth 6150, Australia.

Borrelia are tick-borne bacteria that in humans are the aetiological agents of Lyme disease and relapsing fever. Here we present the first genomes of B. turcica and B. Read More

View Article
September 2018
26 Reads

Holistic approach in patients with presumed Lyme borreliosis leads to less than 10% of confirmation and more than 80% of antibiotics failure.

Clin Infect Dis 2018 Sep 18. Epub 2018 Sep 18.

Sorbonne Université, AP-HP, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Service de Maladies infectieuses et Tropicales, Paris, France.

Background: There is no precise idea whether patients with chronic symptoms attributed to Lyme borreliosis (LB) have LB or another disease.

Methods: We evaluated patients consulting for a presumed LB with a holistic approach including presumptive treatment. We included symptomatic patients who consulted with a presumed LB. Read More

View Article
September 2018
14 Reads

Effects of temperature on bacterial microbiome composition in Ixodes scapularis ticks.

Microbiologyopen 2018 Sep 21:e00719. Epub 2018 Sep 21.

Tick Borne Disease Research Laboratory, Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, Texas.

Ixodes scapularis, the blacklegged deer tick, is the principal vector of Lyme disease in North America. Environmental factors are known to influence regional and seasonal incidence of Lyme disease and possibly the endemicity of the disease to the northeastern and upper mid-western regions of the United States. With a goal to understand the impact of environmental temperature on microbial communities within the tick, we investigated the bacterial microbiome of colony-reared I. Read More

View Article
September 2018
1 Read

Better drugs for Lyme disease: focus on the spirochete.

Infect Drug Resist 2018 7;11:1437-1439. Epub 2018 Sep 7.

Atkins Veterinary Services, Calgary, AB, Canada.

Twenty-five years ago, the AIDS epidemic was wreaking havoc around the world. Although "HIV denialists" threatened to undermine research efforts to combat the epidemic, development of targeted antiviral therapy eventually provided effective treatment for the disease. Now the Lyme disease epidemic is wreaking havoc around the world, and "Lyme denialists" are undermining efforts to combat the epidemic. Read More

View Article
September 2018
1 Read

Deer ked: a Lyme-carrying ectoparasite on the move.

Cutis 2018 Aug;102(2):121-122

Department of Dermatology, University of Connecticut, Farmington, USA.

, known as the deer ked, is an ectoparasite of cervids traditionally found in northern European countries such as Norway, Sweden, and Finland. Although rarely reported in the United States, this vector recently has been shown to carry and from specimens collected domestically. Importantly, it has been suggested that deer keds are one of the many disease-carrying vectors that are now found in more expansive regions of the world due to climate change. Read More

View Article
August 2018
1 Read

Variable clinical presentations of babesiosis.

Nurse Pract 2018 Oct;43(10):48-54

Pamela Paparone is an NP at the Atlantic County Health Department, Northfield, N.J. Philip W. Paparone is a communicable disease physician at the Atlantic County Health Department, Northfield, N.J.

Human babesiosis continues to spread in multiple regions of the US. It is transmitted by Ixodes species ticks, as are Lyme disease and anaplasmosis. Its variable clinical presentations, together with serologic detection limitations, require that a high index of clinical suspicion be present for prompt diagnosis. Read More

View Article
October 2018
5 Reads

Transfusion-Associated Lyme Disease - Although Unlikely, It Is Still a Concern Worth Considering.

Front Microbiol 2018 4;9:2070. Epub 2018 Sep 4.

Department of Clinical Specialties, New York Institute of Technology College of Osteopathic Medicine, New York, NY, United States.

Even though hematogenous spread of the Lyme disease spirochete, , has been well documented, and there are more than 300,000 cases per year of Lyme disease in the United States, no evidence (anecdotal or published) of transfusion-associated Lyme disease has been reported. Such a possibility would seem to exist but various factors, as discussed in this perspective, make this less likely to occur. Nonetheless, if not done already, safeguards need to be put in place at blood collection and dispensing facilities, possibly with the assistance of diagnostic microbiology and immunology laboratories, to ensure that the potential for the transfer of the Lyme disease spirochete through a blood transfusion remains a theoretical consideration rather than a real possibility. Read More

View Article
September 2018
2 Reads

Global Profiling of Lysine Acetylation in B31 Reveals Its Role in Central Metabolism.

Front Microbiol 2018 31;9:2036. Epub 2018 Aug 31.

Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

The post-translational modification of proteins has been shown to be extremely important in prokaryotes. Using a highly sensitive mass spectrometry-based proteomics approach, we have characterized the acetylome of . As previously reported for other bacteria, a relatively low number (5%) of the potential genome-encoded proteins of were acetylated. Read More

View Article
August 2018
1 Read