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    1 OF 252

    Molecular identification of tick-borne pathogens in asymptomatic individuals with human immunodeficiency virus type 1 (HIV-1) infection: a retrospective study.
    BMC Infect Dis 2018 May 18;18(1):227. Epub 2018 May 18.
    Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, 3C Pawińskiego Street, 02-106, Warsaw, Poland.
    Background: The studies on the occurrence and diversity of tick-borne infections in HIV-infected individuals have been few, and the subject has been relatively neglected when compared with other common infections associated with HIV. In HIV-positive patients in whom a serological diagnostics is complicated due to reduced positive predictive value, a method where the microorganism is detected directly is of great value. Therefore, we performed a molecular study to ascertain the prevalence and incidence of tick-borne infections in HIV-infected persons in Poland, an endemic area for Ixodes ricinus ticks. Read More

    Shifts in Borrelia burgdorferi (s.l.) geno-species infections in Ixodes ricinus over a 10-year surveillance period in the city of Hanover (Germany) and Borrelia miyamotoi-specific Reverse Line Blot detection.
    Parasit Vectors 2018 May 18;11(1):304. Epub 2018 May 18.
    Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Buenteweg 17, 30559, Hanover, Germany.
    Background: Lyme borreliosis caused by spirochetes of the Borrelia burgdorferi (sensu lato) complex is still the most common tick-borne disease in Europe, posing a considerable threat to public health. The predominant vector in Europe is the widespread hard tick Ixodes ricinus, which also transmits the relapsing fever spirochete B. miyamotoi as well as pathogenic Rickettsiales (Anaplasma phagocytophilum, Rickettsia spp. Read More

    Clinical evaluation of Morgellons disease in a cohort of North American patients.
    Dermatol Reports 2018 Apr 24;10(1):7660. Epub 2018 Apr 24.
    Union Square Medical Associates, San Francisco, CA, USA.
    Morgellons disease (MD) is a dermatological condition characterized by aberrant production of keratin and collagen fibers in skin. Although infection with , the causative agent of Lyme disease (LD), has been associated with MD, relatively few studies have hitherto provided epidemiological evidence regarding this association. A cohort of 1000 seropositive North American LD patients was evaluated for the presence of MD. Read More

    Human Babesiosis Caused by Has Widespread Distribution across Canada.
    Healthcare (Basel) 2018 May 17;6(2). Epub 2018 May 17.
    International Lyme and Associated Diseases Society, Bethesda, MD 20827, USA.
    Human babesiosis caused by is an emerging infectious disease in Canada. This malaria-like illness is brought about by a protozoan parasite infecting red blood cells. Currently, controversy surrounds which tick species are vectors of Since the availability of a serological or molecular test in Canada for has been limited, we conducted a seven-year surveillance study (2011⁻2017) to ascertain the occurrence and geographic distribution of infection country-wide. Read More

    Review of methods to prevent and reduce the risk of Lyme disease.
    Can Commun Dis Rep 2015 Jun 4;41(6):146-153. Epub 2015 Jun 4.
    Communicable Disease Control Program, Department of National Defence, Ottawa, ON.
    Background: Cases of Lyme disease and areas with self-sustaining populations of vector ticks are increasing in Canada. This trend is expected to continue. Preventing Lyme disease will therefore become relevant to an increasing number of Canadians. Read More

    Surveillance for Lyme disease in Canada, 2009 to 2012.
    Can Commun Dis Rep 2015 Jun 4;41(6):132-145. Epub 2015 Jun 4.
    Surveillance and Assessment Branch, Alberta Health, Calgary, AB.
    Objectives: To summarize the first four years of national surveillance for Lyme disease in Canada from 2009 to 2012 and to conduct a preliminary comparison of presenting clinical manifestations in Canada and the United States.

    Methods: The numbers and incidence of reported cases by province, month, year, age and sex were calculated. Logistic regression was used to examine trends over time. Read More

    Citizen science: Exploring its application as a tool for prodromic surveillance of vector-borne disease.
    Can Commun Dis Rep 2015 Mar 5;41(3):63-67. Epub 2015 Mar 5.
    The Schulich Interfaculty Program in Public Health, Western University, London, ON.
    Citizen science is the systematic collection and analysis of data, development of technology, testing of natural phenomena and the dissemination of these activities by researchers on a primarily avocational or voluntary basis. The application of citizen science-informed mobile applications (apps) provides a means for Canadians to participate in the surveillance of infectious disease. This article makes the case for a mobile application that can be used to enhance the surveillance of vector-borne diseases in Canada. Read More

    Summary of the Public Health Agency of Canada's .
    Can Commun Dis Rep 2014 Mar 6;40(5):88-90. Epub 2014 Mar 6.
    Public Health Agency of Canada, Centre for Food-borne, Environmental and Zoonotic Infectious Diseases.
    Background: Lyme disease is an emerging infectious disease in Canada that requires a comprehensive approach to prevention and control. It is a serious illness caused by a bacterium transmitted by certain types of ticks. The risk of Lyme disease currently exists in southern parts of British Columbia and Manitoba, southern and eastern Ontario, southern Quebec and New Brunswick, and in some locations in Nova Scotia. Read More

    Assessment of a screening test to identify Lyme disease risk.
    Can Commun Dis Rep 2014 Mar 6;40(5):83-87. Epub 2014 Mar 6.
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba.
    Background: Lyme disease is emerging in eastern and central Canada due to the spread of the tick vector . Currently, the test to establish Lyme disease-endemic areas requires multiple site visits and multiple sampling methods, and is consequently complex, time-consuming, and resource-expensive.

    Objective: To assess the capacity of drag sampling alone as a screening technique to identify areas of Lyme disease risk. Read More

    Environmental risk from Lyme disease in central and eastern Canada: a summary of recent surveillance information.
    Can Commun Dis Rep 2014 Mar 6;40(5):74-82. Epub 2014 Mar 6.
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba.
    Background: Lyme disease is the most commonly reported vector-borne disease in the temperate world. It is emerging in central and eastern Canada due to spread of the tick vector into and within Canada to form new areas of environmental risk known as Lyme disease-endemic areas. Identifying the geographic location of Lyme disease-endemic areas is important to identify the population at risk, target interventions, and inform the clinical diagnosis of Lyme disease patients. Read More

    Laboratory diagnostics for Lyme disease.
    Can Commun Dis Rep 2014 May 29;40(11):209-217. Epub 2014 May 29.
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba.
    Background: Lyme disease is on the rise in Canada. It is a notifiable disease, and when infection is disseminated, serological testing provides supplemental evidence to confirm a case.

    Objective: To describe the current diagnostic tests for Lyme disease, review the recommended approach to laboratory testing for Lyme disease and identify future research priorities for Lyme disease laboratory diagnostics in Canada. Read More

    Lyme disease: clinical diagnosis and treatment.
    Can Commun Dis Rep 2014 May 29;40(11):194-208. Epub 2014 May 29.
    Department of Medicine, CDHA and Dalhousie University, Halifax, Nova Scotia.
    Background: Lyme disease is an emerging zoonotic infection in Canada. As the tick expands its range, more Canadians will be exposed to the bacterium that causes Lyme disease.

    Objective: To review the clinical diagnosis and treatment of Lyme disease for front-line clinicians. Read More

    Synopsis: Lyme Disease in Canada - A Federal Framework.
    • Authors:
    Can Commun Dis Rep 2017 Oct 5;43(10):212-214. Epub 2017 Oct 5.
    The required the federal government to develop a Federal Framework on Lyme Disease. To do this, the Public Health Agency of Canada held a conference with a wide variety of stakeholders who shared their experiences with Lyme disease, and discussed current knowledge and research. A draft version of the Framework was publicly posted on Canada. Read More

    Emerging infectious diseases: prediction and detection.
    Can Commun Dis Rep 2017 Oct 5;43(10):206-211. Epub 2017 Oct 5.
    South African Centre for Epidemiological Modelling and Analysis, University of Stellenbosch, Western Cape, South Africa.
    Emerging infectious diseases (EIDs), including West Nile virus, severe acute respiratory syndrome (SARS) and Lyme disease, have had a direct effect within Canada, while many more EIDs such as Zika, chikungunya and Ebola are a threat to Canadians while travelling. Over 75% of EIDs affecting humans are, or were originally, zoonoses (infectious diseases transmitted from animals to humans). There are two main ways by which infectious diseases can emerge: by changes in their geographical ranges and by adaptive emergence, a genetic change in a microorganism that results in it becoming capable of invading a new niche, often by jumping to a new host species such as humans. Read More

    Surveillance for Lyme disease in Canada: 2009-2015.
    Can Commun Dis Rep 2017 Oct 5;43(10):194-199. Epub 2017 Oct 5.
    Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint-Hyacinthe, QC.
    Objective: To summarize seven years of surveillance data for Lyme disease cases reported in Canada from 2009 to 2015.

    Methods: We describe the incidence over time, seasonal and geographic distribution, demographic and clinical characteristics of reported Lyme disease cases. Logistic regression was used to explore differences between age groups, sex and year to better understand potential demographic risk factors for the occurrence of Lyme disease. Read More

    What's eating you? Ixodes tick and related diseases, part 2: diagnosis and treatment of regional tick-borne diseases.
    Cutis 2018 Apr;101(4):266;268;305
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
    The tick is an important arthropod vector in the transmission of human disease. Although Lyme disease is the most prevalent zoonosis transmitted by Ixodes ticks, other less common diseases may be encountered, including human granulocytic anaplasmosis, babesiosis, Powassan virus infection, tick-borne encephalitis, disease, and tick paralysis. In part 2 of this review, disease presentation, diagnosis, and treatment of these less commonly encountered tick-borne diseases are discussed. Read More

    Borrelia burgdorferi surface-located Lmp1 protein processed into region-specific polypeptides that are critical for microbial persistence.
    Cell Microbiol 2018 May 10:e12855. Epub 2018 May 10.
    Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
    One of the Borrelia burgdorferi virulence determinants, annotated as Lmp1, is a surface-exposed, conserved and potential multi-domain protein involved in various functions in spirochete infectivity. Lmp1 contributes to host-pathogen interactions and evasion of host adaptive immunity by spirochetes. Here we show that in diverse B. Read More

    Human neuroglial cells internalize Borrelia burgdorferi by coiling phagocytosis mediated by Daam1.
    PLoS One 2018 10;13(5):e0197413. Epub 2018 May 10.
    Bacterial Diseases Branch, Division of Vector Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America.
    Borrelia burgdorferi, the agent of Lyme borreliosis, can elude hosts' innate and adaptive immunity as part of the course of infection. The ability of B. burgdorferi to invade or be internalized by host cells in vitro has been proposed as a mechanism for the pathogen to evade immune responses or antimicrobials. Read More

    Efficient detection of symptomatic and asymptomatic patient samples for Babesia microti and Borrelia burgdorferi infection by multiplex qPCR.
    PLoS One 2018 10;13(5):e0196748. Epub 2018 May 10.
    Department of Microbiology, Biochemistry and molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America.
    Background: Tick-borne infections have been increasing steadily over the years, with co-infections with Borrelia burgdorferi and Babesia microti/divergens emerging as a serious health problem. B. burgdorferi is a spirochetal bacterium that causes Lyme disease while protozoan pathogens belonging to Babesia species are responsible for babesiosis. Read More

    Evaluation of Modified Two-Tiered Testing Algorithms for Lyme Disease Laboratory Diagnosis Using Well-Characterized Serum Samples.
    J Clin Microbiol 2018 May 9. Epub 2018 May 9.
    Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    Standard two-tiered testing (STTT) is the recommended algorithm for laboratory diagnosis of Lyme disease (LD). Several limitations are associated with STTT that include low sensitivity in the early stages of disease, as well as technical complexity and subjectivity associated with second-tier immunoblots; therefore, modified two-tiered testing (MTTT) algorithms that utilize two sequential first-tier tests and eliminate immunoblots have been evaluated. Recently, a novel MTTT that uses a VlsE chemiluminescence immunoassay followed by a C6 enzyme immunoassay has been proposed. Read More

    Tick-borne disease risk in a forest food web.
    Ecology 2018 May 8. Epub 2018 May 8.
    Cary Institute of Ecosystem Studies, Millbrook, NY, 12545, USA.
    Changes to the community ecology of hosts for zoonotic pathogens, particularly rodents, are likely to influence the emergence and prevalence of zoonotic diseases worldwide. However, the complex interactions between abiotic factors, pathogens, vectors, hosts, and both food resources and predators of hosts are difficult to disentangle. Here we (1) use 19 years of data from six large field plots in southeastern New York to compare the effects of hypothesized drivers of interannual variation in Lyme disease risk, including the abundance of acorns, rodents, and deer, as well as a series of climate variables; and (2) employ landscape epidemiology to explore how variation in predator community structure and forest cover influences spatial variation in the infection prevalence of ticks for the Lyme disease bacterium, Borrelia burgdorferi, and two other important tick-borne pathogens, Anaplasma phagocytophilum and Babesia microti. Read More

    A case of Lyme disease in a Japanese woman.
    Infect Drug Resist 2018 26;11:625-628. Epub 2018 Apr 26.
    Department of Bacteriology-1, National Institute of Infectious Diseases, Tokyo, Japan.
    This report presents the case of a Japanese patient who developed Lyme disease. The patient was a 44-year-old woman who had general fatigue and the inability to open her mouth. She was initially suspected of having mild tetanus with lockjaw; however, she reported a past history of a tick bite while camping in the USA and had erythema migrans 2 months before this visit. Read More

    Borrelia burgdorferi adhere to blood vessels in the dura mater and are associated with increased meningeal T cells during murine disseminated borreliosis.
    PLoS One 2018 3;13(5):e0196893. Epub 2018 May 3.
    Trauma, Health & Hazards Center, University of Colorado, Colorado Springs, Colorado, United States of America.
    Borrelia burgdorferi, the causative agent of Lyme disease, is a vector-borne bacterial infection that is transmitted through the bite of an infected tick. If not treated with antibiotics during the early stages of infection, disseminated infection can spread to the central nervous system (CNS). In non-human primates (NHPs) it has been demonstrated that the leptomeninges are among the tissues colonized by B. Read More

    Vital Signs: Trends in Reported Vectorborne Disease Cases - United States and Territories, 2004-2016.
    MMWR Morb Mortal Wkly Rep 2018 May 4;67(17):496-501. Epub 2018 May 4.
    Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Fort Collins, Colorado.
    Introduction: Vectorborne diseases are major causes of death and illness worldwide. In the United States, the most common vectorborne pathogens are transmitted by ticks or mosquitoes, including those causing Lyme disease; Rocky Mountain spotted fever; and West Nile, dengue, and Zika virus diseases. This report examines trends in occurrence of nationally reportable vectorborne diseases during 2004-2016. Read More

    Effects of a zoonotic pathogen, , on the behavior of a key reservoir host.
    Ecol Evol 2018 Apr 26;8(8):4074-4083. Epub 2018 Mar 26.
    Bard College Annandale-on-Hudson NY USA.
    Most emerging infectious diseases of humans are transmitted to humans from other animals. The transmission of these "zoonotic" pathogens is affected by the abundance and behavior of their wildlife hosts. However, the effects of infection with zoonotic pathogens on behavior of wildlife hosts, particularly those that might propagate through ecological communities, are not well understood. Read More

    Outcome of facial palsy from Lyme disease in prospectively followed patients who had received corticosteroids.
    Diagn Microbiol Infect Dis 2018 Apr 4. Epub 2018 Apr 4.
    Division of General Internal Medicine, New York Medical College, Valhalla, NY 10595.
    Although a short course of corticosteroid therapy has been shown to improve the outcome of idiopathic facial nerve palsy (Bell's palsy), it is unclear whether corticosteroids, in addition to antibiotic therapy, are beneficial, are harmful, or have no impact on the outcome of facial palsy from Lyme disease (LDFP). From 2011 through 2016, 14 patients with LDFP were enrolled into a prospective study to determine the outcome of Lyme disease over the ensuing 12 months. Eleven (78. Read More

    What's eating you? Ixodes tick and related diseases, part 1: life cycle, local reactions, and lyme disease.
    Cutis 2018 Mar;101(3):187-190
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
    The tick is an important arthropod vector in the transmission of human disease. This 3-part review highlights the biology of the tick and manifestations of related diseases. Part 1 addresses the tick biology and life cycle; local reactions; and Lyme disease, the most prevalent of associated diseases. Read More

    Low probability of a dilution effect for Lyme borreliosis in Belgian forests.
    Ticks Tick Borne Dis 2018 Apr 22. Epub 2018 Apr 22.
    Forest & Nature Lab, Department of Environment, Ghent University, Geraardsbergsesteenweg 267, 9090, Melle-Gontrode, Belgium. Electronic address:
    An increasing number of studies have investigated the consequences of biodiversity loss for the occurrence of vector-borne diseases such as Lyme borreliosis, the most common tick-borne disease in the northern hemisphere. As host species differ in their ability to transmit the Lyme borreliosis bacteria Borrelia burgdorferi s.l. Read More

    Seroprevalence of Borrelia burgdorferi in Belgian forestry workers and associated risk factors.
    Parasit Vectors 2018 May 2;11(1):277. Epub 2018 May 2.
    Earth and Life Institute (ELI), Georges Lemaitre Center for Earth and Climate Research, Université catholique de Louvain (UCL), Louvain-la-Neuve, Belgique.
    Background: As forest is the preferred environment for ticks, forestry workers are exposed to tick bites and tick-borne diseases. We assessed the seroprevalence of anti-Borrelia burgdorferi (Bb) antibodies and investigated, using an integrated landscape approach, the individual and environmental factors associated with the seroprevalence of Bb in Belgian forestry workers, a high-risk group in Belgium.

    Methods: A group of 310 Belgian forest workers was examined to assess the seroprevalence of anti-Borrelia IgG antibodies. Read More

    [Pathway to diagnosis and real-life experience of patients believing they are affected by "chronic Lyme disease"].
    Rev Med Interne 2018 Apr 26. Epub 2018 Apr 26.
    Aix-les Bains, France.
    Objectives: Chronic Lyme disease is a subject of scientific and social controversy in both Europe and the United States. The aim of our study was to analyze the pathway to diagnosis of patients believing they were affected by the disease, and to describe their real-life experience.

    Method: A qualitative study was performed with 13 patients declaring themselves to be affected by chronic Lyme disease. Read More

    Neurosyphilis: mighty imitator forays with benign presentation and unique neuroimaging findings.
    Sex Health 2018 Apr 30. Epub 2018 Apr 30.
    Common causes of temporal lobe hyper intensities are central nervous system infections like herpes simplex encephalitis, Lyme disease, limbic encephalitis and vascular pathology like Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy. Personal assessment, laboratory data analysis and neuroimaging for the patient who was admitted to a central Pennsylvania tertiary care referral centre were conducted. A 52-year-old male presented with a 1-year history of diffuse dysesthesia in upper and lower extremities with associated intermittent headaches and neck stiffness. Read More

    Modeling Climate Suitability of the Western Blacklegged Tick in California.
    J Med Entomol 2018 Apr 25. Epub 2018 Apr 25.
    Department of Environmental Science, Policy and Management, University of California, Berkeley, CA.
    Ixodes pacificus Cooley & Kohls (Acari: Ixodidae), the primary vector of Lyme disease spirochetes to humans in the far-western United States, is broadly distributed across Pacific Coast states, but its distribution is not uniform within this large, ecologically diverse region. To identify areas of suitable habitat, we assembled records of locations throughout California where two or more I. pacificus were collected from vegetation from 1980 to 2014. Read More

    orrelia host aptation rotein (BadP) is required for the colonization of a mammalian host by the agent of Lyme disease.
    Infect Immun 2018 Apr 23. Epub 2018 Apr 23.
    South Texas Center for Emerging Infectious Diseases (STCEID), Center of Excellence in Infection Genomics and Department of Biology, The University of Texas at San Antonio, San Antonio, TX-78249
    (), the agent of Lyme disease (LD), uses host-derived signals to modulate gene expression during the vector and mammalian phases of infection. Microarray analysis of mutants lacking orrelia host-aptation egulator (BadR) revealed down-regulation of genes encoding enzymes whose role in the patho-physiology of is unknown. Immunoblot analysis of the mutants confirmed reduced levels of these enzymes and one of these enzymes encoded by , shares homology to prokaryotic magnesium chelatase and Lon-type proteases. Read More

    The role of Ixodes scapularis, Borrelia burgdorferi and wildlife hosts in Lyme disease prevalence: A quantitative review.
    Ticks Tick Borne Dis 2018 Apr 16. Epub 2018 Apr 16.
    Program in Ecology, Evolution and Conservation Biology, University of Illinois at Urbana-Champaign, United States; Department of Natural Resources and Environmental Sciences, University of Illinois at Urbana-Champaign, United States.
    Due to the ongoing expansion of Ixodes scapularis (blacklegged tick) throughout the northeastern and midwestern United States, there is need to identify the role wildlife hosts play in the establishment and maintenance of tick populations. To quantify and synthesize the patterns of I. scapularis and Borrelia burgdorferi sensu stricto and sensu lato prevalence relative to wildlife hosts, we reviewed the findings of independent studies conducted throughout the United States. Read More

    Seven cases of probable endotoxin poisoning related to contaminated glutathione infusions.
    Epidemiol Infect 2018 May 20;146(7):931-934. Epub 2018 Apr 20.
    Public Health Unit,Population Health Unit,Sydney Local Health District,Sydney,Australia.
    We report seven cases of probable endotoxin poisoning linked to contaminated compounded glutathione. Five of the cases were using the infusions for treatment of Lyme disease highlighting the risks of using compounded sterile preparations for unapproved indications, especially if the quality of source products cannot be assured. Read More

    Adverse Events Associated with Antibiotics and Intravenous Therapies for Post-Lyme Disease Syndrome in a Commercially Insured Sample.
    Clin Infect Dis 2018 Apr 17. Epub 2018 Apr 17.
    Department of Pharmacy Practice, Midwestern University College of Pharmacy, Glendale, AZ, USA.
    Background: Non-guideline endorsed post-treatment courses of antibiotics for post-Lyme disease syndrome (PLDS) have been linked to adverse patient outcomes, but these findings have yet to be validated in large systematic evaluations.

    Methods: A retrospective cohort analysis of medical and pharmacy claims derived from the Truven Health Market Scan® Commercial Claims and Encounters Database assessed 90-day incidence rates of adverse events (AEs) associated with PLDS treatments (PLDS-TX). Patients were diagnosed with PLDS ≥6 months after initial diagnosis and standard antibiotic treatment for Lyme disease. Read More

    Integrated Social-Behavioral and Ecological Risk Maps to Prioritize Local Public Health Responses to Lyme Disease.
    Environ Health Perspect 2018 04 18;126(4):047008. Epub 2018 Apr 18.
    Groupe de recherche en épidémiologie des zoonoses et santé publique (GREZOSP), Faculté de médecine vétérinaire (FMV), Université de Montréal, Saint-Hyacinthe, Québec, Canada
    Background: The risk of contracting Lyme disease (LD) can vary spatially because of spatial heterogeneity in risk factors such as social-behavior and exposure to ecological risk factors. Integrating these risk factors to inform decision-making should therefore increase the effectiveness of mitigation interventions.

    Objectives: The objective of this study was to develop an integrated social-behavioral and ecological risk-mapping approach to identify priority areas for LD interventions. Read More

    Relapsing Fevers: Neglected Tick-Borne Diseases.
    Front Cell Infect Microbiol 2018 4;8:98. Epub 2018 Apr 4.
    Early Bacterial Virulence: Borrelia Group, Université de Strasbourg, Facultés de Médecine et de Pharmacie, CHRU Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, VBB EA 7290, Strasbourg, France.
    Relapsing fever still remains a neglected disease and little is known on its reservoir, tick vector and physiopathology in the vertebrate host. The disease occurs in temperate as well as tropical countries. Relapsing fever borreliae are spirochaetes, members of the family which also contain Lyme disease spirochaetes. Read More

    Lactoferrin is a natural inhibitor of plasminogen activation.
    J Biol Chem 2018 Apr 18. Epub 2018 Apr 18.
    Molecular Immunology Unit, Medical University of Vienna, Austria.
    The plasminogen system is essential for dissolution of fibrin clots, and in addition, it is involved in a wide variety of other physiological processes, including proteolytic activation of growth factors, cell migration, and removal of protein aggregates. On the other hand, uncontrolled plasminogen activation contributes to many pathological processes, e.g. Read More

    Hip Synovial Fluid Cell Counts in Children From a Lyme Disease Endemic Area.
    Pediatrics 2018 May 18;141(5). Epub 2018 Apr 18.
    Divisions of Emergency Medicine and
    Background: Patients with septic hip arthritis require surgical drainage, but they can be difficult to distinguish from patients with Lyme arthritis. The ability of synovial fluid white blood cell (WBC) counts to help discriminate between septic and Lyme arthritis of the hip has not been investigated.

    Methods: We assembled a retrospective cohort of patients ≤21 years of age with hip monoarticular arthritis and a synovial fluid culture obtained who presented to 1 of 3 emergency departments located in Lyme disease endemic areas. Read More

    Collapse in the elderly: rivastigmine-induced heart block and a literature review of the pharmacology of acetylcholinesterase inhibitors used in Alzheimer's disease.
    BMJ Case Rep 2018 Apr 17;2018. Epub 2018 Apr 17.
    Senior Health Department, St Georges University Hospital, London, UK.
    Falls resulting in neck of femur fractures are common in the elderly. Often multiple comorbidities can make management and diagnosis of such a polyfactorial condition difficult, particularly with Alzheimer's dementia (AD). Indeed, poorly managed AD may contribute to falls. Read More

    Dynamics of Spirochetemia and Early PCR Detection of Borrelia miyamotoi.
    Emerg Infect Dis 2018 May;24(5):860-867
    We investigated whether Borrelia miyamotoi disease can be detected in its early stage by using PCR for borrelial 16S rRNA, which molecule (DNA or RNA) is the best choice for this test, and whether spirochetes are present in blood during the acute phase of B. miyamotoi disease. A total of 473 patients with a suspected tickborne infection in Yekaterinburg, Russia, in 2009, 2010, and 2015 were enrolled in this study. Read More

    Borrelia miyamotoi sensu lato in Père David Deer and Haemaphysalis longicornis Ticks.
    Emerg Infect Dis 2018 May;24(5):928-931
    By sequence analysis of 16S rRNA, flaB, p66, and glpQ, we identified Borrelia miyamotoi in 1 of 4 Père David deer (n = 43) seropositive for Borrelia spp. and 1.2% (3/244) of Haemaphysalis longicornis ticks from Dafeng Elk National Natural Reserve, China. Read More

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