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    1 OF 240

    Evaluation of Modified 2-Tiered Serodiagnostic Testing Algorithms for Early Lyme Disease.
    Clin Infect Dis 2017 Jan 27. Epub 2017 Jan 27.
    Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.
    Background.: The conventional 2-tiered serologic testing protocol for Lyme disease (LD), an enzyme immunoassay (EIA) followed by immunoglobulin M and immunoglobulin G Western blots, performs well in late-stage LD but is insensitive in patients with erythema migrans (EM), the most common manifestation of the illness. Western blots are also complex, difficult to interpret, and relatively expensive. Read More

    Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi In Vitro.
    Antibiotics (Basel) 2017 Mar 22;6(1). Epub 2017 Mar 22.
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
    Lyme disease is a most common vector-borne disease in the US. Although the majority of Lyme patients can be cured with the standard two- to four-week antibiotic treatment, at least 10%-20% of patients continue to suffer from prolonged post-treatment Lyme disease syndrome (PTLDS). While the cause for this is unclear, one possibility is that persisting organisms are not killed by current Lyme antibiotics. Read More

    There Is a Method to the Madness: Strategies to Study Host Complement Evasion by Lyme Disease and Relapsing Fever Spirochetes.
    Front Microbiol 2017 2;8:328. Epub 2017 Mar 2.
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health Albany, NY, USA.
    Lyme disease and relapsing fever are caused by various Borrelia species. Lyme disease borreliae, the most common vector-borne pathogens in both the U.S. Read More

    Lyme Disease: Emergency Department Considerations.
    J Emerg Med 2017 Mar 10. Epub 2017 Mar 10.
    Emergency Center, University Medical Center, Lubbock, Texas.
    Background: Lyme disease (LD) is the most common vector-borne illness in North America. Reported cases of LD have increased from approximately 10,000 cases annually in 1991 to >25,000 cases in 2014. Greater recognition, enhanced surveillance, and public education have contributed to the increased prevalence, as have geographic expansion and the number of infected ticks. Read More

    Metabolomics of the tick-Borrelia interaction during the nymphal tick blood meal.
    Sci Rep 2017 Mar 13;7:44394. Epub 2017 Mar 13.
    Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA.
    The causal agents of Lyme disease in North America, Borrelia burgdorferi and Borrelia mayonii, are transmitted primarily by Ixodes scapularis ticks. Due to their limited metabolic capacity, spirochetes rely on the tick blood meal for nutrients and metabolic intermediates while residing in the tick vector, competing with the tick for nutrients in the blood meal. Metabolomics is an effective methodology to explore dynamics of spirochete survival and multiplication in tick vectors before transmission to a vertebrate host via tick saliva. Read More

    Diet-Induced Obesity Does Not Alter Tigecycline Treatment Efficacy in Murine Lyme Disease.
    Front Microbiol 2017 24;8:292. Epub 2017 Feb 24.
    Matrix Dynamics Group, Faculty of Dentistry, University of TorontoToronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of TorontoToronto, ON, Canada.
    Obese individuals more frequently suffer from infections, as a result of increased susceptibility to a number of bacterial pathogens. Furthermore, obesity can alter antibiotic treatment efficacy due to changes in drug pharmacokinetics which can result in under-dosing. However, studies on the treatment of bacterial infections in the context of obesity are scarce. Read More

    Searching for Lyme borreliosis in Australia: results of a canine sentinel study.
    Parasit Vectors 2017 Mar 13;10(1):114. Epub 2017 Mar 13.
    Department of Infectious Diseases and Zoonoses, Bacteriology and Mycology, Ludwig-Maximilians-University Munich, 80539, Munich, Germany.
    Background: Lyme borreliosis is a common tick-borne disease of the northern hemisphere that is caused by bacterial spirochaetes of the Borrelia burgdorferi (sensu lato) (Bbsl) complex. To date, there has been no convincing evidence for locally-acquired Lyme borreliosis on the Australian continent and there is currently a national debate concerning the nature and distributions of zoonotic tick-transmitted infectious disease in Australia. In studies conducted in Europe and the United States, dogs have been used as sentinels for tick-associated illness in people since they readily contact ticks that may harbour zoonotic pathogens. Read More

    Electrocardiographic progression of acute Lyme disease.
    Am J Emerg Med 2017 Mar 1. Epub 2017 Mar 1.
    Heart Rhythm Service, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada. Electronic address:
    Lyme carditis poses a challenge to physicians given dramatic clinical presentations like the one presented in this case. Quite frequently, these young patients are implanted with permanent pacemakers; given lack of knowledge on the transient nature of the cardiac conduction system inflammation. This is the first case in the literature that has captured the electrocardiographic evolution of Lyme carditis, day by day until complete resolution. Read More

    Borrelia burgdorferi Keeps Moving and Carries on: A Review of Borrelial Dissemination and Invasion.
    Front Immunol 2017 21;8:114. Epub 2017 Feb 21.
    Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Science Center , Bryan, TX , USA.
    Borrelia burgdorferi is the etiological agent of Lyme disease, a multisystemic, multistage, inflammatory infection resulting in patients experiencing cardiac, neurological, and arthritic complications when not treated with antibiotics shortly after exposure. The spirochetal bacterium transmits through the Ixodes vector colonizing the dermis of a mammalian host prior to hematogenous dissemination and invasion of distal tissues all the while combating the immune response as it traverses through its pathogenic lifecycle. The innate immune response controls the borrelial burden in the dermis, but is unable to clear the infection and thereby prevent progression of disease. Read More

    Melting pot of tick-borne zoonoses: the European hedgehog contributes to the maintenance of various tick-borne diseases in natural cycles urban and suburban areas.
    Parasit Vectors 2017 Mar 7;10(1):134. Epub 2017 Mar 7.
    Centre for Infectious Disease Control, National Institute of Public Health and Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3720 BA, Bilthoven, The Netherlands.
    Background: European hedgehogs (Erinaceus europaeus) are urban dwellers and host both Ixodes ricinus and Ixodes hexagonus. These ticks transmit several zoonotic pathogens like Borrelia burgdorferi (sensu lato), Anaplasma phagocytophilum, Rickettsia helvetica, Borrelia miyamotoi and "Candidatus Neoehrlichia mikurensis". It is unclear to what extent hedgehogs in (sub) urban areas contribute to the presence of infected ticks in these areas, which subsequently pose a risk for acquiring a tick-borne disease. Read More

    Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts.
    Front Immunol 2017 20;8:116. Epub 2017 Feb 20.
    Graduate Group in Immunology, University of California Davis, Davis, CA, USA; Center for Comparative Medicine, University of California Davis, Davis, CA, USA; Department of Pathology, Microbiology and Immunology, University of California Davis, Davis, CA, USA.
    Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of the pathogen with its natural hosts. However, infected humans and other incidental hosts can develop Lyme disease, a serious inflammatory syndrome characterized by tissue inflammation of joints, heart, muscles, skin, and CNS. Read More

    Use of a Targeted Urine Proteome Assay (TUPA) to identify protein biomarkers of delayed recovery after kidney transplant.
    Proteomics Clin Appl 2017 Mar 6. Epub 2017 Mar 6.
    Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.
    Purpose: Development of delayed graft function (DGF) following kidney transplant is associated with poor outcomes. An ability to rapidly identify patients with DGF versus those with immediate graft function (IGF) may facilitate the treatment of DGF and the research needed to improve prognosis. The purpose of this study was to use a Targeted Urine Proteome Assay (TUPA) to identify protein biomarkers of delayed recovery from kidney transplant. Read More

    Borrelia Diversity and Co-infection with Other Tick Borne Pathogens in Ticks.
    Front Cell Infect Microbiol 2017 14;7:36. Epub 2017 Feb 14.
    INRA, UMR Bipar, INRA, Anses, ENVA Maisons-Alfort, France.
    Identifying Borrelia burgdorferi as the causative agent of Lyme disease in 1981 was a watershed moment in understanding the major impact that tick-borne zoonoses can have on public health worldwide, particularly in Europe and the USA. The medical importance of tick-borne diseases has long since been acknowledged, yet little is known regarding the occurrence of emerging tick-borne pathogens such as Borrelia spp., Anaplasma phagocytophilum, Rickettsia spp. Read More

    Tick Humoral Responses: Marching to the Beat of a Different Drummer.
    Front Microbiol 2017 14;8:223. Epub 2017 Feb 14.
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore MD, USA.
    Ticks transmit a variety of human pathogens, including Borrelia burgdorferi, the etiological agent of Lyme disease. Multiple pathogens that are transmitted simultaneously, termed "coinfections," are of increasing importance and can affect disease outcome in a host. Arthropod immunity is central to pathogen acquisition and transmission by the tick. Read More

    Detection of Lyme Disease Bacterium, Borrelia burgdorferi sensu lato, in Blacklegged Ticks Collected in the Grand River Valley, Ontario, Canada.
    Int J Med Sci 2017 8;14(2):150-158. Epub 2017 Feb 8.
    Department of Biology, Georgia Southern University, Statesboro, Georgia 30458, USA.
    We document the presence of blacklegged ticks, Ixodes scapularis, in the Grand River valley, Centre Wellington, Ontario. Overall, 15 (36%) of 42 I. scapularis adults collected from 41 mammalian hosts (dogs, cats, humans) were positive for the Lyme disease bacterium, Borrelia burgdorferi sensu lato (s. Read More

    Evaluation of a serological test for the diagnosis of Borrelia miyamotoi disease in Europe.
    J Microbiol Methods 2017 Mar 1;136:11-16. Epub 2017 Mar 1.
    Central Research Institute of Epidemiology, Moscow, Russia. Electronic address:
    Background: Borrelia miyamotoi causes systemic febrile illness and is transmitted by the same tick species that transmits Borrelia burgdorferi sensu lato and tick-borne encephalitis virus. We describe a serological test using a fragment of glycerophosphodiester phosphodiesterase (GlpQ) as an antigen, and determined its performance in well-defined patient categories.

    Methods: Serum of patients with PCR-confirmed Borrelia miyamotoi disease (BMD), Lyme borreliosis (LB), tick-borne encephalitis (TBE), and healthy blood donors (HBD) were collected in Udmurt Republic, Russia. Read More

    Vancomycin Reduces Cell Wall Stiffness and Slows Swim Speed of the Lyme Disease Bacterium.
    Biophys J 2017 Feb;112(4):746-754
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona; Department of Physics, University of Arizona, Tucson, Arizona. Electronic address:
    Borrelia burgdorferi, the spirochete that causes Lyme disease, is a tick-transmitted pathogen that requires motility to invade and colonize mammalian and tick hosts. These bacteria use a unique undulating flat-wave shape to penetrate and propel themselves through host tissues. Previous mathematical modeling has suggested that the morphology and motility of these spirochetes depends crucially on the flagellar/cell wall stiffness ratio. Read More

    Determination of Seroprevalence of Borrelia burgdorferi IgG in Adult Population Living in Trabzon.
    Balkan Med J 2017 Jan 5;34(1):47-52. Epub 2017 Jan 5.
    Department of Medical Microbiology, Karadeniz Technical University School of Medicine, Trabzon, Turkey.
    Background: Lyme borreliosis is a tick-borne, multi-systemic infectious disease that is thought to be wide spread in Turkey even though studies on its seroprevalence are limited.

    Aims: To determine the seroprevalence of Lyme borreliosis in part of north-eastern Tur-key (in the city of Trabzon), and to identify possible relationships between seropositivity and various factors such as location, gender, age group, occupation, income, and educational level.

    Study Design: Retrospective cross-sectional study. Read More

    [Cutaneous manifestations of Lyme disease : Pitfalls in the serological diagnostic workup].
    Hautarzt 2017 Feb 24. Epub 2017 Feb 24.
    Abteilung für Dermatologie, Landesklinikum Wiener Neustadt, Wiener Neustadt, Österreich.
    Serology, the detection of B. burgdorferi-specific IgM and IgG serum antibodies, is the most common laboratory test to diagnose cutaneous manifestations of Lyme disease. In a two-tiered approach, an ELISA is used as a screening test. Read More

    The Lyme disease as the increasing health problem in Małopolskie voivodeship compared with Poland in 1998-2014
    Przegl Epidemiol 2016 ;70(4):529-538
    Department of Hygiene and Dietetics, Jagiellonian University Medical College
    Objective: Lyme disease is one of the most known tick borne diseases in Poland caused by spirochetes of the genus Borrelia burgdorferi. Most cases of Lyme disease are diagnosed in the northeastern Poland and the south of Poland, in Śląskie, Małopolskie, Podkarpackie voivodeship. The aim of the study was to evaluate epidemiological data of Lyme disease in Małopolskie voivodeship and other voivodeships in Poland and frequency analysis of the Lyme disease as an occupational disease. Read More

    A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species.
    PLoS Pathog 2017 Feb 17;13(2):e1006225. Epub 2017 Feb 17.
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, United States of America.
    Borrelia burgdorferi, the causative agent of Lyme disease in humans, is exposed to reactive oxygen and nitrogen species (ROS and RNS) in both the tick vector and vertebrate reservoir hosts. B. burgdorferi contains a limited repertoire of canonical oxidative stress response genes, suggesting that novel gene functions may be important for protection of B. Read More

    Tick-borne pathogens induce differential expression of genes promoting cell survival and host resistance in Ixodes ricinus cells.
    Parasit Vectors 2017 Feb 15;10(1):81. Epub 2017 Feb 15.
    Animal and Plant Health Agency (APHA), Woodham Lane, New Haw, Surrey, KT15 3NB, UK.
    Background: There has been an emergence and expansion of tick-borne diseases in Europe, Asia and North America in recent years, including Lyme disease, tick-borne encephalitis and human anaplasmosis. The primary vectors implicated are hard ticks of the genus Ixodes. Although much is known about the host response to these bacterial and viral pathogens, there is limited knowledge of the cellular responses to infection within the tick vector. Read More

    Plasmid diversity and phylogenetic consistency in the Lyme disease agent Borrelia burgdorferi.
    BMC Genomics 2017 Feb 15;18(1):165. Epub 2017 Feb 15.
    Department of Biology, The Graduate Center, City University of New York City, New York, NY, USA.
    Background: Bacteria from the genus Borrelia are known to harbor numerous linear and circular plasmids. We report here a comparative analysis of the nucleotide sequences of 236 plasmids present in fourteen independent isolates of the Lyme disease agent B. burgdorferi. Read More

    Infection-derived lipids elicit an immune deficiency circuit in arthropods.
    Nat Commun 2017 Feb 14;8:14401. Epub 2017 Feb 14.
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
    The insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans present in Gram-negative bacteria. Whether unidentified chemical moieties activate the IMD signalling cascade remains unknown. Here, we show that infection-derived lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and 1-palmitoyl-2-oleoyl diacylglycerol (PODAG) stimulate the IMD pathway of ticks. Read More

    A Serosurvey of Diseases of Free-Ranging Gray Wolves (Canis lupus) in Minnesota.
    J Wildl Dis 2017 Feb 13. Epub 2017 Feb 13.
    7   1854 Treaty Authority, Resource Management Division, 4428 Haines Rd., Duluth, Minnesota 55811, USA.
    We tested serum samples from 387 free-ranging wolves ( Canis lupus ) from 2007 to 2013 for exposure to eight canid pathogens to establish baseline data on disease prevalence and spatial distribution in Minnesota's wolf population. We found high exposure to canine adenoviruses 1 and 2 (88% adults, 45% pups), canine parvovirus (82% adults, 24% pups), and Lyme disease (76% adults, 39% pups). Sixty-six percent of adults and 36% of pups exhibited exposure to the protozoan parasite Neospora caninum . Read More

    Antibody responses to Borrelia burgdorferi detected by western blot vary geographically in Canada.
    PLoS One 2017 9;12(2):e0171731. Epub 2017 Feb 9.
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
    Lyme disease is emerging in eastern and central Canada, and most cases are diagnosed using the two-tier serological test (Enzyme Immuno Assay [EIA] followed by Western blot [WB]). Simplification of this algorithm would be advantageous unless it impacts test performance. In this study, accuracy of individual proteins of the IgG WB algorithm in predicting the overall test result in samples from Canadians was assessed. Read More

    Genome scaffolding and annotation for the pathogen vector Ixodes ricinus by ultra-long single molecule sequencing.
    Parasit Vectors 2017 Feb 8;10(1):71. Epub 2017 Feb 8.
    Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
    Background: Global warming and other ecological changes have facilitated the expansion of Ixodes ricinus tick populations. Ixodes ricinus is the most important carrier of vector-borne pathogens in Europe, transmitting viruses, protozoa and bacteria, in particular Borrelia burgdorferi (sensu lato), the causative agent of Lyme borreliosis, the most prevalent vector-borne disease in humans in the Northern hemisphere. To faster control this disease vector, a better understanding of the I. Read More

    [Neuroborreliosis - Diagnostics, treatment and course].
    Nervenarzt 2017 Feb 7. Epub 2017 Feb 7.
    Abteilung für Neurologie und Neurophysiologie, Universitätsklinikum Freiburg, Breisacher Str. 64, 79106, Freiburg, Deutschland.
    Lyme neuroborreliosis is a tick-borne infectious disease caused by the spirochete bacterium Borrelia burgdorferi sensu lato. Clinical manifestations are classified as early and late Lyme neuroborreliosis. Early manifestations are much more common than late manifestations. Read More

    Molecular and structural characterization of novel cystatins from the taiga tick Ixodes persulcatus.
    Ticks Tick Borne Dis 2017 Mar 31;8(3):432-441. Epub 2017 Jan 31.
    Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves, 9500, Prédio 43421, Porto Alegre 91501-970, RS, Brazil; Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves, 9090, Porto Alegre 91540-000, RS, Brazil; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Brazil. Electronic address:
    Cystatins are cysteine peptidase inhibitors that in ticks mediate processes such as blood feeding and digestion. The ixodid tick Ixodes persulcatus is endemic to the Eurasia, where it is the principal vector of Lyme borreliosis. To date, no I. Read More

    Tuberculosis 'The Great Imitator': A usual disease with unusual presentations.
    Indian J Tuberc 2017 Jan 4;64(1):54-59. Epub 2016 Jul 4.
    Lecturer, Dept. of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.
    Background: A number of infectious diseases have been referred to by the phrase 'The Great Imitator', of which the oldest is syphilis; others include Lyme disease, nocardiosis, etc. Tuberculosis has been described as the second great imitator as it can imitate various other disease processes. An awareness of the atypical clinical manifestations of tuberculosis is important, especially in regions where tuberculosis continues to be a major public health problem, such as India. Read More

    Closely-related Borrelia burgdorferi (sensu stricto) strains exhibit similar fitness in single infections and asymmetric competition in multiple infections.
    Parasit Vectors 2017 Feb 6;10(1):64. Epub 2017 Feb 6.
    Ecology, Evolution, and Environmental Biology Department, Columbia University, 1200 Amsterdam Ave, New York, NY, 10027, USA.
    Background: Wild hosts are commonly co-infected with complex, genetically diverse, pathogen communities. Competition is expected between genetically or ecologically similar pathogen strains which may influence patterns of coexistence. However, there is little data on how specific strains of these diverse pathogen species interact within the host and how this impacts pathogen persistence in nature. Read More

    Chronic Lyme borreliosis associated with minimal change glomerular disease: a case report.
    BMC Nephrol 2017 Feb 6;18(1):51. Epub 2017 Feb 6.
    Department of Nephrology, Dialysis and Hypertension, Edouard Herriot Hospital, Hospices Civils de Lyon, 5 Place d'Arsonval, 69437, Lyon, Cedex 03, France.
    Background: There are only few cases of renal pathology induced by Lyme borreliosis in the literature, as this damage is rare and uncommon in humans. This patient is the first case of minimal change glomerular disease associated with chronic Lyme borreliosis.

    Case Presentation: A 65-year-old Caucasian woman was admitted for an acute edematous syndrome related to a nephrotic syndrome. Read More

    The first case of imported Borrelia miyamotoi disease concurrent with Lyme disease.
    J Infect Chemother 2017 Feb 2. Epub 2017 Feb 2.
    National Institute of Infectious Diseases, Bacteriology-I, Japan.
    Borrelia miyamotoi disease (BMD) is an emerging infectious disease caused by B. miyamotoi. Although BMD has been reported in the United States, Europe, and Japan, no case of imported BMD has been described in the world. Read More

    Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies for Borrelia miyamotoi.
    Front Immunol 2017 19;8:12. Epub 2017 Jan 19.
    Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota , Grand Forks, ND , USA.
    The emerging pathogen, Borrelia miyamotoi, is a relapsing fever spirochete vectored by the same species of Ixodes ticks that carry the causative agents of Lyme disease in the US, Europe, and Asia. Symptoms caused by infection with B. miyamotoi are similar to a relapsing fever infection. Read More

    Bridging of cryptic Borrelia cycles in European songbirds.
    Environ Microbiol 2017 Feb 2. Epub 2017 Feb 2.
    Center for Vector and Infectious Diseases Research, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal.
    The principal European vector for Borrelia burgdorferi s.l., the causative agents of Lyme disease, is the host-generalist tick Ixodes ricinus. Read More

    Nested-PCR real time as alternative molecular tool for detection of Borrelia burgdorferi compared to the classical serological diagnosis of the blood.
    Med Dosw Mikrobiol 2016;68(1):47-56
    Introduction: Lyme disease, caused by Borrelia burgdorferi, is a multisystem disease that often makes difficulties to recognize caused by their genetic heterogenity. Currently, the gold standard for the detection of Lyme disease (LD) is serologic diagnostics based mainly on tests: ELISA and Western blot (WB). These methods, however, are subject to consider- able defect, especially in the initial phase of infection due to the occurrence of so-called serological window period and low specificity. Read More

    Lyme Carditis: A Case Involving the Conduction System and Mitral Valve.
    R I Med J (2013) 2017 Feb 1;100(2):17-20. Epub 2017 Feb 1.
    Clinical Assistant Professor of Medicine, Warren Alpert Medical School of Brown University, Providence, RI.
    Lyme disease is the most common tick-borne infection in the Northern hemisphere. Cardiac manifestations of Lyme disease typically include variable atrioventricular nodal block and rarely structural heart pathology. The incidence of Lyme carditis may be underestimated based on current reporting practices of confirmed cases. Read More

    Safety, immunogenicity, and efficacy of Borrelia burgdorferi outer surface protein A (OspA) vaccine: A meta-analysis.
    J Infect Dev Ctries 2017 Jan 30;11(1):1-9. Epub 2017 Jan 30.
    Kunming Medical University, Kunming, China.
    Introduction: Lyme borreliosis, caused by Borrelia burgdorferi sensu stricto in the United States and by several Borrelia species in Europe and Asia, has a great impact on the health of the global population. There are human vaccines available, such as the outer surface protein A (OspA) vaccine, but still more evidence is needed to verify its function. We investigated the safety, immunogenicity, and efficacy of adjuvanted or non-adjuvanted vaccines containing protective epitopes from Borrelia species OspA serotypes in healthy adults. Read More

    Using exploratory data analysis to identify and predict patterns of human Lyme disease case clustering within a multistate region, 2010-2014.
    Spat Spatiotemporal Epidemiol 2017 Feb 12;20:35-43. Epub 2017 Jan 12.
    West Virginia University School of Public Health, One Medical Center Drive, PO Box 9190, Morgantown, WV 26506, United States ; West Virginia Bureau of Public Health Office of Epidemiology and Preventative Services, 350 Capital St., Charleston, WV 25301, United States.
    Lyme disease is the most commonly reported vectorborne disease in the United States. The objective of our study was to identify patterns of Lyme disease reporting after multistate inclusion to mitigate potential border effects. County-level human Lyme disease surveillance data were obtained from Kentucky, Maryland, Ohio, Pennsylvania, Virginia, and West Virginia state health departments. Read More

    MicroRNA and mRNA Transcriptome Profiling in Primary Human Astrocytes Infected with Borrelia burgdorferi.
    PLoS One 2017 30;12(1):e0170961. Epub 2017 Jan 30.
    Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, United States of America.
    Lyme disease is caused by infection with the bacterium Borrelia burgdorferi (Bb), which is transmitted to humans by deer ticks. The infection manifests usually as a rash and minor systemic symptoms; however, the bacteria can spread to other tissues, causing joint pain, carditis, and neurological symptoms. Lyme neuroborreliosis presents itself in several ways, such as Bell's palsy, meningitis, and encephalitis. Read More

    Development and optimization of an in vitro cultivation protocol allows for isolation of Borrelia miyamotoi from patients with hard tick-borne relapsing fever.
    Clin Microbiol Infect 2017 Jan 18. Epub 2017 Jan 18.
    Center for Experimental and Molecular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:
    Objectives: Borrelia miyamotoi has been shown to infect humans in Eurasia and North America causing hard tick-borne relapsing fever (HTBRF). In vitro cultivation of B. miyamotoi was described recently; but clinical isolation of relapsing fever Borrelia is cumbersome. Read More

    Influences of Host Community Characteristics on Borrelia burgdorferi Infection Prevalence in Blacklegged Ticks.
    PLoS One 2017 17;12(1):e0167810. Epub 2017 Jan 17.
    Cary Institute of Ecosystem Studies, 2801 Sharon Turnpike, Millbrook, NY, United States of America.
    Lyme disease is a major vector-borne bacterial disease in the USA. The disease is caused by Borrelia burgdorferi, and transmitted among hosts and humans, primarily by blacklegged ticks (Ixodes scapularis). The ~25 B. Read More

    Co-feeding transmission facilitates strain coexistence in Borrelia burgdorferi, the Lyme disease agent.
    Epidemics 2016 Dec 26. Epub 2016 Dec 26.
    Columbia University, Department of Ecology, Evolution, and Environmental Biology, 1200 Amsterdam Avenue, New York, NY 10027, USA. Electronic address:
    Coexistence of multiple tick-borne pathogens or strains is common in natural hosts and can be facilitated by resource partitioning of the host species, within-host localization, or by different transmission pathways. Most vector-borne pathogens are transmitted horizontally via systemic host infection, but transmission may occur in the absence of systemic infection between two vectors feeding in close proximity, enabling pathogens to minimize competition and escape the host immune response. In a laboratory study, we demonstrated that co-feeding transmission can occur for a rapidly-cleared strain of Borrelia burgdorferi, the Lyme disease agent, between two stages of the tick vector Ixodes scapularis while feeding on their dominant host, Peromyscus leucopus. Read More

    Ticks and Borrelia in urban and peri-urban green space habitats in a city in southern England.
    Ticks Tick Borne Dis 2017 Mar 21;8(3):353-361. Epub 2016 Dec 21.
    Medical Entomology & Zoonoses Ecology, Emergency Response Department - Science & Technology, Health Protection Directorate, Public Health England, Porton Down, UK; NIHR Health Protection Research Unit in Environmental Change and Health, UK; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, UK.
    Ticks are becoming increasingly recognised as important vectors of pathogens in urban and peri-urban areas, including green space used for recreational activities. In the UK, the risk posed by ticks in such areas is largely unknown. In order to begin to assess the risk of ticks in urban/peri-urban areas in southern England, questing ticks were collected from five different habitat types (grassland, hedge, park, woodland and woodland edge) in a city during the spring, summer and autumn of 2013/2014 and screened for Borrelia burgdorferi sensu lato. Read More

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