12,694 results match your criteria Lyme Disease
Emerg Nurse 2018 Aug 9. Epub 2018 Aug 9.
University of Chester, Chester, England.
Over the past ten years there has been a significant rise in the number of people who present to emergency departments with Lyme disease. Although some patients remain asymptomatic many present with a rash around a previous tick bite and others may present with a range of debilitating symptoms that can be problematic if left untreated. Due to the growing prevalence of Lyme disease in the UK and the US this article gives an overview of the vector-borne condition and provides emergency nurses with information about the pathophysiology, prevention, presenting signs and symptoms and management. Read More
Pediatr Emerg Care 2018 Aug;34(8):588-591
Assistant Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Lyme disease is the most common vector-borne illness in North America, with the majority of cases occurring in the Northeast and upper Midwest. Lyme arthritis is the most prevalent manifestation of late-stage Lyme disease. Lyme arthritis typically presents as a monoarthritis or oligoarthritis in large joints such as the knee. Read More
Wien Klin Wochenschr 2018 Aug 3;130(15-16):484-490. Epub 2018 Aug 3.
Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
The recent proposal of splitting the genus Borrelia into two genera in the newly formed family of Borreliaceae, i. e. Borrelia and Borreliella has motivated us to reflect upon how these organisms has been characterized and differentiated. Read More
JAMA 2018 Aug 2. Epub 2018 Aug 2.
Division of Infectious Diseases, New York Medical College, Valhalla.
Front Immunol 2018 18;9:1634. Epub 2018 Jul 18.
Stanford University School of Medicine, Stanford, CA, United States.
Lyme disease ( infection) is increasingly recognized as a significant source of morbidity worldwide. Here, we show that blood plasmablasts and CD27 memory B cells are elevated in untreated Lyme disease, with higher plasmablast levels associated with more rapid resolution of clinical symptoms. Stronger serum reactivity to surface proteins and peptides from was also associated with faster resolution of clinical symptoms. Read More
BMC Infect Dis 2018 Aug 2;18(1):362. Epub 2018 Aug 2.
Department of medical microbiology, VU medical center, De Boelelaan 1117, Amsterdam, 1081, HV, The Netherlands.
Background: Infection with Borrelia burgdorferi sensu lato complex (B. b. sl) spirochetes can cause Lyme borreliosis, manifesting as localized infection (e. Read More
J Prev Med Public Health 2018 Jul 7;51(4):213-214. Epub 2018 Jun 7.
Department of Preventive Medicine, Jeju National University School of Medicine, Jeju, Korea.
Lyme borreliosis (LB) is the most common tick-borne infectious disease in North America, and it was designated as a national notifiable infectious disease in Korea in December 2010. While no cases in Jeju-do were recorded from 2012 to 2016, a recent survey reported that the seroprevalence of using enzyme-linked immunosorbent assays in horses in Jeju-do was 19.0% (95% confidence interval, 12. Read More
Proc Biol Sci 2018 Aug 1;285(1884). Epub 2018 Aug 1.
Department of Biological and Environmental Science, University of Jyväskylä, PO Box 35, 40014, Jyväskylä, Finland.
The impact of a pathogen on the fitness and behaviour of its natural host depends upon the host-parasite relationship in a given set of environmental conditions. Here, we experimentally investigated the effects of one of the aetiological agents of Lyme disease in humans, on the fitness of its natural rodent host, the bank vole (), in semi-natural conditions with two contrasting host population densities. Our results show that can modify the reproductive success and spacing behaviour of its rodent host, whereas host survival was not affected. Read More
Rev Invest Clin 2018 ;70(4):158-163
Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.
Lyme disease (LD) is a multisystemic inflammatory disease caused by pathogenic spirochetes, belonging to the genospecies complex Borrelia burgdorferi sensu lato (B.b.s. Read More
Pediatr Infect Dis J 2018 Jul 31. Epub 2018 Jul 31.
Emergency Medicine, Boston Children's Hospital, Boston, MA.
Knowing the frequency of positive Lyme disease serology in children without signs of infection facilitates test interpretation. Of 315 asymptomatic children from Lyme disease endemic regions, 32 had positive or equivocal C6 enzyme linked immunoassays, but only 5 had positive IgG or IgM supplemental immunoblots (1.6%, 95% confidence interval 0. Read More
Parasitology 2018 Aug 1:1-7. Epub 2018 Aug 1.
State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology,Beijing 100071,P.R. China.
Northeastern China is a region of high tick abundance, multiple tick-borne pathogens and likely human infections. The spectrum of diseases caused by tick-borne pathogens has not been objectively evaluated in this region for clinical management and for comparison with other regions globally where tick-transmitted diseases are common. Based on clinical symptoms, PCR, indirect immunofluorescent assay and (or) blood smear, we identified and described tick-borne diseases from patients with recent tick bite seen at Mudanjiang Forestry Central Hospital. Read More
PLoS One 2018 31;13(7):e0201665. Epub 2018 Jul 31.
Department of Biology, Stanford University, Stanford, California, United States of America.
The distribution, abundance and seasonal activity of vector species, such as ticks and mosquitoes, are key determinants of vector-borne disease risk, and are strongly influenced by abiotic and habitat conditions. Despite the numerous species of tick vectors in the heavily populated North American West Coast, all but Ixodes pacificus, the primary vector of the Lyme disease spirochete, is poorly characterized with regard to seasonal activity patterns and fine scale drivers of distribution and abundance, particularly in heavily populated regions of southern California. This lack of knowledge inhibits both scientific understanding and public health efforts to minimize vector exposure and risk of pathogen transmission to humans. Read More
Front Psychiatry 2018 13;9:314. Epub 2018 Jul 13.
National Reference Laboratory for Lyme Disease, National Institute of Public Health, Prague, Czechia.
Several recent studies have demonstrated the association of cat-related injuries with major depression and with depressiveness in the general population. It was suggested that cat-scratch disease, the infection with the bacterium , can be responsible for the observed association. However, no direct evidence for the role of the infection in this association has been published until now. Read More
BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.
Hospital Internal Medicine: Community Division, Mayo Clinic Health System, Rochester, Minnesota, USA.
A 45-year-old man was presented with 3 weeks of fever, chills, headache, myalgia and sweats after returning from a camping trip. He had multiple erythematous, blanching, non-target lesions on back and lower abdomen and oral pseudomembrane. He was empirically started on doxycycline for presumed Lyme disease and hydration for management of acute renal failure. Read More
J Pediatric Infect Dis Soc 2018 Jul 30. Epub 2018 Jul 30.
Department of Pediatric Infectious Diseases, Children's National Health System, Washington, DC.
We performed a retrospective study to determine the time frame for symptom resolution in 78 pediatric patients hospitalized with laboratory-confirmed early-disseminated or late-stage Lyme disease. The vast majority of the patients improved promptly after receiving appropriate antibiotics. Patients with a longer duration of arthritis before the institution of therapy experienced a longer time to recovery. Read More
Arch Biochem Biophys 2018 Jul 27;654:105-114. Epub 2018 Jul 27.
Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2d, 15-222, Bialystok, Poland.
Objectives: Distinguishing of rheumatoid arthritis (RA) and Lyme arthritis (LA) is difficult, because of similar symptoms. This presents a significant clinical problem since treatments are quite different in both diseases. We investigated the plasma phospholipid profiles of RA and LA patients versus healthy subjects to find metabolic changes responsible for differentiation of both diseases. Read More
Parasitol Res 2018 Jul 30. Epub 2018 Jul 30.
Dipartimento di Scienze Agrarie e Agroambientali, Università degli Studi di Milano, Via Celoria 2, 20133, Milan, Italy.
Introduced Siberian chipmunks Eutamias sibiricus have been reported to be important reservoirs for human Lyme disease, as they may host high numbers of hard ticks carrying Borrelia spp. and other pathogens. In the present study, we assessed the prevalence of Borrelia spp. Read More
J Infect Chemother 2018 Jul 26. Epub 2018 Jul 26.
Department of Bacteriology-I, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan. Electronic address:
Since 2011, Borrelia miyamotoi disease (BMD) has been reported in five countries in the northern hemisphere. The causative agent of BMD is transmitted by Ixodes ticks, which are also vectors of Lyme disease borreliae. In this study, we examined 459 cases of clinically suspected Lyme disease (LD group), and found twelve cases that were seropositive for the glycerophosphodiester phosphodiesterase (GlpQ) antigen derived from B. Read More
Ticks Tick Borne Dis 2018 Jul 20. Epub 2018 Jul 20.
Bacterial Diseases Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Rd., Fort Collins, CO 80521, United States. Electronic address:
In the north-central United States, the blacklegged tick (Ixodes scapularis) is currently known to vector seven human pathogens. These include five bacteria (Borrelia burgdorferi sensu stricto, Borrelia mayonii, Borrelia miyamotoi, Anaplasma phagocytophilum, Ehrlichia muris eauclairensis), one protozoan (Babesia microti) and one virus (Powassan). We sought to assess the prevalence and distribution of these pathogens in host-seeking nymphs collected throughout Minnesota, a state on the northwestern edge of the tick's expanding range, where reported cases of I. Read More
Front Cell Infect Microbiol 2018 11;8:213. Epub 2018 Jul 11.
Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA, United States.
Cyclic-di-GMP (c-di-GMP) contributes to the regulation of processes required by the Lyme disease (LD) spirochetes to complete the tick-mammal enzootic cycle. Our understanding of the effector mechanisms of c-di-GMP in the is evolving. While most LD spirochete isolates encode a single PilZ domain containing c-di-GMP receptor designated as PlzA, genome analyses have revealed that a subset encode a second PilZ domain protein (PlzB). Read More
WMJ 2018 Jun;117(2):83-87
Division of General Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Introduction: Optic neuritis is a condition associated with various systemic diseases, such as multiple sclerosis, and is also considered a rare complication of Lyme disease.
Case: A 46-year-old white woman presented with sudden onset of bilateral vision loss. After extensive workup, she was diagnosed with Lyme optic neuritis based on the clinical presentation and positive serology. Read More
Wien Klin Wochenschr 2018 Aug 25;130(15-16):468-478. Epub 2018 Jul 25.
Psychiatric Department, SMZ-Ost-Donauspital, Vienna, Austria.
Dementia-like syndromes are rare manifestations of Lyme neuroborreliosis. The clinical patterns are summarized using our own cases and case reports from the literature, which were diagnosed as definite Lyme neuroborreliosis according to the European guidelines. The cases disclose signs of subcortical dementia that occur more rapidly than in patients suffering from primary dementia. Read More
Medicine (Baltimore) 2018 07;97(30):e11413
AP-HP, Hôpital Saint Antoine, Service de Médecine Interne et Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris.
The aim of this study was to determine the characteristics, treatment, and outcome according to each etiology of pachymeningitis.We conducted a retrospective multicenter French nationwide study between 2000 and 2016 to describe the characteristics, outcome, and treatment of pachymeningitis.We included 60 patients (median age 55. Read More
Healthcare (Basel) 2018 Jul 25;6(3). Epub 2018 Jul 25.
Department of Biology, Georgia Southern University, Statesboro, GA 30458, USA.
Lyme disease has been documented in northern areas of Canada, but the source of the etiological bacterium, sensu lato (Bbsl) has been in doubt. We collected 87 ticks from 44 songbirds during 2017, and 24 (39%) of 62 nymphs of the blacklegged tick, , were positive for Bbsl. We provide the first report of Bbsl-infected, songbird-transported in Cape Breton, Nova Scotia; Newfoundland and Labrador; north-central Manitoba, and Alberta. Read More
Emerg Infect Dis 2018 Sep 17;24(9). Epub 2018 Sep 17.
In 2017, we surveyed forests in the upper Tennessee Valley, Tennessee, USA. We found Ixodes scapularis ticks established in 23 of 26 counties, 4 of which had Borrelia burgdorferi sensu stricto-infected ticks. Public health officials should be vigilant for increasing Lyme disease incidence in this region. Read More
Ned Tijdschr Geneeskd 2018 Jul 5;162. Epub 2018 Jul 5.
Wilhelmina Ziekenhuis, afd. Neurologie, Assen.
Background: Lyme disease is a multisystem disease which can present itself in several ways. When the nervous system is involved, it is called Lyme neuroborreliosis. Both central and peripheral nervous systems can be affected. Read More
Hosp Pharm 2018 Jul 2;53(4):263-265. Epub 2018 Jan 2.
University of Pittsburgh Medical Center Mercy, PA, USA.
A case report of a patient who presented with an acute onset, fluctuating atrioventricular (AV) block and was diagnosed with Lyme carditis is presented. A 55-year-old man with progressively worsening generalized malaise, flu-like symptoms, dyspnea on exertion, and near syncope was admitted with bradycardia (heart rate was between 20 and 30 beats per minute upon admission). He endorsed having several tick bites after which he developed erythema migrans on his arm and abdomen. Read More
Viruses 2018 07 22;10(7). Epub 2018 Jul 22.
Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
ticks harbor a variety of microorganisms, including eukaryotes, bacteria and viruses. Some of these can be transmitted to and cause disease in humans and other vertebrates. Others are not pathogenic, but may impact the ability of the tick to harbor and transmit pathogens. Read More
Front Immunol 2018 3;9:1540. Epub 2018 Jul 3.
Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Ticks are blood-feeding arthropods that can transmit pathogens to humans and animals, leading to serious infectious diseases such as Lyme disease. After single or multiple tick infestation, some animal species develop resistance to tick feeding, leading to reduced risk of pathogen transmission. In mice infested with larval ticks, both mast cells and basophils reportedly play key roles in the manifestation of acquired tick resistance (ATR), but it remains ill-defined how they contribute to it. Read More
Healthcare (Basel) 2018 Jul 19;6(3). Epub 2018 Jul 19.
Department of Anthropology, Binghamton University, Binghamton, NY 13902, USA.
Seasonal variation in spatial distribution and pathogen prevalence of in blacklegged ticks () influences human population risk of Lyme disease in peri-urban built environments. Parks, gardens, playgrounds, school campuses and neighborhoods represent a significant risk for Lyme disease transmission. From June 2012 through May 2014, ticks were collected using 1 m² corduroy cloths dragged over low-lying vegetation parallel to walkways with high human foot traffic. Read More
Nurse Pract 2018 Aug;43(8):13-21
Scott J. Saccomano is an assistant professor in the College of Health and Human Services at the University of North Carolina, Wilmington, N.C. Debra A. Hrelic is the academic program coordinator for the University of North Carolina, Wilmington, in Wilmington, N.C.
Lyme disease is the most commonly reported vector-borne disease in the United States. After initial antibiotic treatment for patients with Lyme disease, ongoing symptoms that may persist have considerable long-term impact on healthcare costs. Posttreatment Lyme disease syndrome is characterized by a host of chronic symptoms that can leave patients physically and mentally disabled. Read More
Front Cell Infect Microbiol 2018 5;8:231. Epub 2018 Jul 5.
Division of Biological Sciences, University of Montana, Missoula, MT, United States.
The Lyme disease spirochete () must tolerate nutrient stress to persist in the tick phase of its enzootic life cycle. We previously found that the stringent response mediated by Rel globally regulates gene expression to facilitate persistence in the tick vector. Here, we show that Rel regulates the expression of a swath of small RNAs (sRNA), affecting 36% of previously identified sRNAs in . Read More
Case Rep Infect Dis 2018 20;2018:6764894. Epub 2018 Jun 20.
Department of Medicine, St. John's Riverside Hospital, 967 N. Broadway Yonkers, NY 10701, USA.
Lyme disease is a multisystem infection caused by the spirochete sensu stricto that manifests with characteristic symptoms in patients. Patients are identified based on their clinical symptoms and then diagnosed through enzyme-linked immunosorbent assay (ELISA), Western blot, and blood culture techniques. Here, we present the case of a 75-year-old, Northeast suburban resident complaining of unstable gait, high fevers, malaise, myalgia, and confusion. Read More
Vector Borne Zoonotic Dis 2018 Jul 18. Epub 2018 Jul 18.
Department of Pathobiology, Ontario Veterinary College, University of Guelph , Guelph, Ontario, Canada .
Tick dragging is an important tool used by public health for Ixodes scapularis surveillance to identify Lyme disease risk areas in Ontario, Canada. Concerns have been raised on the repeatability of tick dragging due to fluctuations that occur in the tick population in response to micro- and macroclimatic variations. Our objective was to assess the repeatability of tick dragging over a short timescale by examining three outcome measures: presence/absence of ticks, tick abundance, and likelihood of tick establishment based on an indicator developed by Clow et al. Read More
J Med Entomol 2018 Jul 18. Epub 2018 Jul 18.
State University of New York College of Environmental Science and Forestry, Syracuse, NY.
Blacklegged ticks (Ixodes scapularis Say, Acari: Ixodidae) are the most commonly encountered and medically relevant tick species in New York State (NY) and have exhibited recent geographic range expansion. Forests and adjacent habitat are important determinants of I. scapularis density and may influence tick-borne pathogen prevalence. Read More
Diagn Microbiol Infect Dis 2018 Jun 18. Epub 2018 Jun 18.
Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.
A critical analysis was conducted of a doxycycline treatment trial of Indian rhesus macaques. In this treatment trial, the investigators attempted to infect the primates with Borrelia burgdorferi sensu stricto by at least 10 tick bites from artificially infected ticks. None of the primates became ill; nevertheless, 5 primates were treated with a 28-day course of oral doxycycline. Read More
Vector Borne Zoonotic Dis 2018 Jul 17. Epub 2018 Jul 17.
1 Department of Epidemiology, University of Iowa College of Public Health , Iowa City, Iowa.
Certain professionals have more exposure to animals and therefore an increased risk of zoonoses. Professional hunting dog caretakers work with upwards of 50 dogs and are exposed to zoonoses through exposure to multiple potentially infectious canine secretions or excretions, as well as to the ticks that dogs carry. Dog caretakers reported having found embedded ticks on their bodies 5. Read More
Cureus 2018 May 10;10(5):e2608. Epub 2018 May 10.
Hospital Medicine, Aspirus Riverview Hospital.
Dermatomyositis (DM) is one of the rare clinical manifestations of tickborne-related autoimmune presentations; we report an uncommon case of Borrelia-related DM-like presentation from rural Wisconsin. A 76-year-old female presented with fatigue, malaise, weight loss and progressive proximal muscle weakness after a flare-up of shoulder arthritis. She had a heliotrope rash and a Shawl sign in addition to generalized cutaneous erythema with edema. Read More
Am J Med 2018 Jul 14. Epub 2018 Jul 14.
From the Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595. Electronic address:
Ticks Tick Borne Dis 2018 Jul 10. Epub 2018 Jul 10.
Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521, United States. Electronic address:
The relapsing fever spirochete, Borrelia miyamotoi, is increasingly recognized as a cause of human illness (hard tick-borne relapsing fever) in the United States. We previously demonstrated that single nymphs of the blacklegged tick, Ixodes scapularis, can transmit B. miyamotoi to experimental hosts. Read More
Vet Clin North Am Equine Pract 2018 Aug;34(2):313-343
Newmarket-Indialantic Equine, Newmarket, NH, USA. Electronic address:
Given the variable clinical signs attributed to Borrelia burgdorferi, including infectious arthritis, neurologic disease, and behavioral changes, B burgdorferi is an important differential for decreased performance in sport horses. The primary vectors (Ixodes tick species) are expanding their range and thus Borrelia species are located in a wider area, making exposure more likely. Due to regionally high seroprevalence and vague clinical signs, diagnosis of Lyme disease in the horse is believed overestimated. Read More
Ticks Tick Borne Dis 2018 Jul 2. Epub 2018 Jul 2.
Groupe de Recherche en Épidémiologie des Zoonoses et Santé Publique, Faculté de médecine vétérinaire, Université de Montréal, 3200 Sicotte, Saint-Hyacinthe, Québec, J2S 2M2, Canada; Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, 3200 Sicotte, Saint-Hyacinthe, Québec, J2S 2M2, Canada.
In North America, different strains of the Lyme disease-causing bacterium Borrelia burgdorferi sensu stricto cluster into phylogenetic groups that are associated with different levels of pathogenicity and, for some, specific rodent reservoir hosts. Here we explore whether landscape connectivity, by impacting host dispersal, influences B. burgdorferi s. Read More
Sci Rep 2018 Jul 12;8(1):10552. Epub 2018 Jul 12.
Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, Saint-Hyacinthe, Québec, J2S 2M2, Canada.
Lyme disease is emerging in southern Canada due to range expansion of the tick vector, followed by invasion of the agent of Lyme disease Borrelia burgdorferi sensu stricto. Strain diversity, as determined by Multi Locus Sequence Typing, occurs in this zone of emergence, and this may have its origins in adaptation to ecological niches, and have phenotypic consequences for pathogenicity and serological test performance. Sixty-four unique strains were cultured from ticks collected in southern Canada and the genomes sequenced using the Illumina MiSeq platform. Read More
PLoS One 2018 12;13(7):e0199644. Epub 2018 Jul 12.
Department of Biology, Colorado State University, Fort Collins, CO, United States of America.
Tick-borne pathogens are increasing their range and incidence in North America as a consequence of numerous factors including improvements in diagnostics and diagnosis, range expansion of primary vectors, changes in human behavior, and an increasing understanding of the diversity of species of pathogens that cause human disease. Public health agencies have access to human incidence data on notifiable diseases e.g. Read More