13,075 results match your criteria Lyme Disease


Emerging Infectious Diseases and Antimicrobial Resistance (EIDAR).

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

University of Nebraska Medical Center College of Public Health, 984355 Medical Center, Omaha, NB 68198.

Introduction: The Infectious Disease Clinical Research Program's (IDCRP) Emerging Infectious Diseases and Antimicrobial Resistance (EIDAR) Research Area is a Department of Defense (DoD) clinical research capability that is responsive and adaptive to emerging infectious disease (EID) threats to US military readiness. Among active-duty and other Military Health System (MHS) beneficiaries, EIDAR research is largely focused on evaluating the incidence, risk factors, and acute- and long-term health effects of military-relevant EIDs, especially those caused by high-consequence pathogens or are responsible for outbreaks among US military populations. The EIDAR efforts also address Force Health Protection concerns associated with antimicrobial resistance and antimicrobial stewardship practices within the MHS. Read More

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http://dx.doi.org/10.1093/milmed/usz081DOI Listing

Borrelia burgdorferi basic membrane protein A initiates proinflammatory chemokine storm in THP 1-derived macrophages via the receptors TLR1 and TLR2.

Biomed Pharmacother 2019 Apr 16;115:108874. Epub 2019 Apr 16.

Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650500, China.

Lyme disease, reffered to as Lyme borreliosis, is a tick-borne zoonotic disease caused by Borrelia burgdorferi spirochetes. Lyme arthritis, the most common, serious and harmful manifestation during the late stages of Lyme disease, is closely associated with the Borrelia burgdorferi basic membrane protein A (BmpA). Chemokines are also reported to have an important role in Lyme arthritis. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108874DOI Listing
April 2019
2 Reads

Lyme disease research gets a needed boost.

Science 2019 Apr 18;364(6437):221. Epub 2019 Apr 18.

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http://dx.doi.org/10.1126/science.364.6437.221DOI Listing

Modeling transmission dynamics of lyme disease: Multiple vectors, seasonality, and vector mobility.

Infect Dis Model 2019 28;4:28-43. Epub 2019 Mar 28.

Department of Mathematics and Statistics, San Diego State University, California, 92182, USA.

Lyme disease is the most prevalent tick-borne disease in the United States, which humans acquire from an infected tick of the genus Ixodes (primarily ). While previous studies have provided useful insights into various aspects of Lyme disease, the tick's host preference in the presence of multiple hosts has not been considered in the existing models. In this study, we develop a transmission dynamics model that includes the interactions between the primary vectors involved: blacklegged ticks (), white-footed mice (), and white-tailed deer (). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680427183005
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http://dx.doi.org/10.1016/j.idm.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453107PMC
March 2019
1 Read

Erythema Migrans-Like Rash Mimicking Lyme Disease.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Japan.

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.2635-19DOI Listing
April 2019
1 Read

New Zealand White rabbits effectively clear B31 despite the bacteria's functional antigenic variation system.

Infect Immun 2019 Apr 15. Epub 2019 Apr 15.

Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical; Sciences, Texas A&M University, College Station, TX 77843, USA

is a tick-borne bacterium responsible for approximately 300,000 annual cases of Lyme disease (LD) in the USA with increasing incidents in other parts of the world. The debilitating nature of LD is mainly attributed to the ability of to persist in patients for many years despite strong anti- antibody responses. Antimicrobial treatment of persistent infection is challenging. Read More

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http://dx.doi.org/10.1128/IAI.00164-19DOI Listing
April 2019
1 Read

Prevalence and determinants of persistent symptoms after treatment for Lyme borreliosis: study protocol for an observational, prospective cohort study (LymeProspect).

BMC Infect Dis 2019 Apr 15;19(1):324. Epub 2019 Apr 15.

National Institute for Public Health and Environment (RIVM), Center for Infectious Disease Control, P.O. Box 1, 3720, BA, Bilthoven, the Netherlands.

Background: After antibiotic treatment of Lyme borreliosis, a subset of patients report persistent symptoms, also referred to as post-treatment Lyme disease syndrome. The reported prevalence of persistent symptoms varies considerably, and its pathophysiology is under debate. The LymeProspect study has been designed to investigate the prevalence, severity, and a wide range of hypotheses on the etiology of persistent symptoms among patients treated for Lyme borreliosis in the Netherlands. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3949-8DOI Listing
April 2019
2 Reads

Antigen Engineering Approaches for Lyme Disease Vaccines.

Bioconjug Chem 2019 Apr 16. Epub 2019 Apr 16.

Increasing rates of Lyme disease necessitate preventive measures such as immunization to mitigate the risk of contracting the disease. At present, there is no human Lyme disease vaccine available on the market, although there was in the past. Since the withdrawal of the first and only licensed Lyme disease vaccine based on lipidated recombinant OspA, vaccine and antigen research has aimed to overcome its risks and shortcomings. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00167DOI Listing
April 2019
1 Read

Model of Risk of Exposure to Lyme Borreliosis and Tick-Borne Encephalitis Virus-Infected Ticks in the Border Area of the Czech Republic (South Bohemia) and Germany (Lower Bavaria and Upper Palatinate).

Int J Environ Res Public Health 2019 Apr 2;16(7). Epub 2019 Apr 2.

Institute of Parasitology, Biology Centre, Academy of Sciences of Czech Republic, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic.

In Europe, Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are the two vector-borne diseases with the largest impact on human health. Based on data on the density of host-seeking ticks and pathogen prevalence and using a variety of environmental data, we have created an acarological risk model for a region where both diseases are endemic (Czech Republic-South Bohemia and Germany-Lower Bavaria, Upper Palatinate). The data on tick density were acquired by flagging 50 sampling sites three times in a single season. Read More

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http://dx.doi.org/10.3390/ijerph16071173DOI Listing
April 2019
1 Read

Laboratory Blood-Based Testing for Lyme Disease at a National Reference Laboratory.

Am J Clin Pathol 2019 Apr 15. Epub 2019 Apr 15.

Quest Diagnostics, Secaucus, NJ.

Objectives: We evaluated trends in Lyme disease (LD) testing at a national reference laboratory.

Methods: LD screening enzyme immunoassay and Western blot testing data performed at Quest Diagnostics during 2010 to 2016 were analyzed nationally and at the state level.

Results: Overall, 593,800 (11. Read More

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http://dx.doi.org/10.1093/ajcp/aqz030DOI Listing
April 2019
6 Reads

[Zoonoses related to leisure activities].

Authors:
Nadia Haddad

Rev Prat 2019 Mar;69(3):336-340

UMR BIPAR, Ecole nationale vétérinaire d'Alfort, Anses, INRA, université Paris-Est, Maisons- Alfort, France.

Zoonoses related to leisure activities. Many zoonoses can be contracted by humans during recreational activities. In the context of a walk, some of them, such as Lyme disease, are transmissible by biological vectors, particularly ticks, or by aerosol (Q fever, hantavirose), whereas others can be contracted in case of aquatic activities (leptospirosis), hunting (tularaemia), and visits to pet farms or fairs (especially the hemolytic uremic syndrome). Read More

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March 2019
3 Reads

Differences between palpation and static/dynamic tests to diagnose painful temporomandibular disorders in patients with Lyme disease.

Clin Oral Investig 2019 Apr 13. Epub 2019 Apr 13.

Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objectives: The aim was to determine the frequency of Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD)-based pain diagnoses and dynamic/static tests-based pain diagnoses, and to assess the agreement of palpation tests with static/dynamic tests.

Materials And Methods: Eighty-six (N = 86) adult patients with Lyme disease (mean age 57.0 ± 14. Read More

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http://dx.doi.org/10.1007/s00784-019-02890-4DOI Listing
April 2019
1 Read

Diversity of the Lyme Disease Spirochetes and its Influence on Immune Responses to Infection and Vaccination.

Vet Clin North Am Small Anim Pract 2019 Apr 6. Epub 2019 Apr 6.

Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University Medical Center, 1112 East Clay Street, Room 101 McGuire Hall, PO Box 980678, Richmond, VA 23298-0678, USA. Electronic address:

The Lyme disease spirochetes are a highly diverse group of bacteria with unique biological properties. Their ability to cycle between ticks and mammals requires that they adapt to variable and constantly changing environmental conditions. Outer surface protein C is an essential virulence determinant that has received considerable attention in vaccine and diagnostic assay development. Read More

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http://dx.doi.org/10.1016/j.cvsm.2019.02.007DOI Listing
April 2019
1 Read

Can Protected Areas Mitigate Lyme Disease Risk in Fennoscandia?

Authors:
Julien Terraube

Ecohealth 2019 Apr 8. Epub 2019 Apr 8.

Global Change and Conservation Lab, Organismal and Evolutionary Biology Research Program, Faculty of Biological and Environmental Sciences, University of Helsinki, PO Box 65, Viikinkaari 1, 00014, Helsinki, Finland.

This Forum article synthesizes the current evidence on the links between predator-prey interactions, protected areas and spatial variations in Lyme disease risk in Fennoscandia. I suggest key research directions to better understand the role of protected areas in promoting the persistence of diverse predator guilds. Conserving predators could help reducing host populations and Lyme disease risk in northern Europe. Read More

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http://dx.doi.org/10.1007/s10393-019-01408-4DOI Listing
April 2019
2 Reads

Extensive meningeal enhancement in acute central nervous system Lyme: Case series and review of literature.

J Clin Neurosci 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.

Introduction: Clinical presentation of the central nervous system Lyme disease is nonspecific and therefore brain imaging and disease-specific serological testing is generally pursued to assist with diagnosis. Brain imaging findings are, however, rare and often unspecific.

Case Description: In the current report, we are presenting a rare magnetic resonance imaging (MRI) finding of extensive meningeal enhancement in two patients with acute Lyme disease. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.048DOI Listing
April 2019
2 Reads

Stationary phase persister/biofilm microcolony of Borrelia burgdorferi causes more severe disease in a mouse model of Lyme arthritis: implications for understanding persistence, Post-treatment Lyme Disease Syndrome (PTLDS), and treatment failure.

Discov Med 2019 03;27(148):125-138

Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

Although most patients with Lyme disease can be cured with a 2-4 week antibiotic therapy, about 10-20% of patients continue to suffer prolonged persistent symptoms, a condition called post-treatment Lyme disease syndrome (PTLDS). The cause for PTLDS is unclear and hotly debated. Borrelia burgdorferi develops morphological variants under stress conditions but their significance is not clear. Read More

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March 2019
3 Reads

Phylogeography of Borrelia spirochetes in Ixodes pacificus and Ixodes spinipalpis ticks highlights differential acarological risk of tick-borne disease transmission in northern versus southern California.

PLoS One 2019 4;14(4):e0214726. Epub 2019 Apr 4.

California Department of Public Health, Vector-Borne Disease Section, Richmond, CA, United States of America.

The common human-biting tick, Ixodes pacificus, is the primary vector of the Lyme disease spirochete, Borrelia burgdorferi sensu stricto (ss) in western North America and has been found to harbor other closely-related spirochetes in the Borrelia burgdorferi sensu lato (sl) complex. Between 2008-2015, 11,066 adult and 3,815 nymphal I. pacificus and five adult and 144 nymphal Ixodes spinpalpis, a commonly collected wildlife tick, were collected from 42 California counties. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214726PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448939PMC
April 2019
12 Reads

A small intergenic region of lp17 is required for evasion of adaptive immunity and induction of pathology by the Lyme disease spirochete.

Cell Microbiol 2019 Apr 3:e13029. Epub 2019 Apr 3.

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.

The causative agent of Lyme disease, Borrelia burgdorferi, harbours a single linear chromosome and upwards of 23 linear and circular plasmids. Only a minority of these plasmids, including linear plasmid 17, are maintained with near-absolute fidelity during extended in vitro passage, and characterisation of any putative virulence determinants they encode has only recently begun. In this work, a mutant lacking a ~4. Read More

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http://dx.doi.org/10.1111/cmi.13029DOI Listing
April 2019
4 Reads

Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses.

Vaccine 2019 Apr 25;37(17):2401-2407. Epub 2019 Mar 25.

Dept. Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA; Division of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA; Department of Large Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA. Electronic address:

As Ixodes ticks spread to new regions, the incidence of Lyme disease (LD) in companion animals and humans will increase. Preventive strategies for LD in canines center on vaccination and tick control (acaricides). Both subunit and bacterin based LD veterinary vaccines are available. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453540PMC
April 2019
2 Reads

Ticks and tick-borne diseases in the city: Role of landscape connectivity and green space characteristics in a metropolitan area.

Sci Total Environ 2019 Mar 16;670:941-949. Epub 2019 Mar 16.

Department of Biology, University of Antwerp, Wilrijk, Belgium.

Green spaces in the city are important for human wellbeing, but are also zones in which humans can become infected with zoonotic diseases. Therefore, there is a need to understand how infection risk is related to green space characteristics, wildlife communities and connectivity with rural areas hosting reservoir populations of hosts. Our hypothesis is that wildlife hosts in urban green spaces, and thereby the prevalence of questing ticks and their Lyme disease causing pathogens (Borrelia burgdorferi s. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.235DOI Listing
March 2019
2 Reads

Lyme neuroborreliosis.

Authors:
John J Halperin

Curr Opin Infect Dis 2019 Mar 27. Epub 2019 Mar 27.

Department of Neurosciences, Overlook Medical Center, Summit, NJ.

Purpose Of Review: To review the recent evidence clarifying the symptomatology and diagnosis of nervous system Lyme disease.

Recent Findings: Two-tier testing combining pairs of ELISAs, using C6 or VlsE assays to replace second tier Western blots, may eliminate confusion about test interpretation. Cerebrospinal fluid (CSF) can be informative in diagnosing central nervous system (CNS) Lyme disease, not peripheral nervous system (PNS) disorders. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000545DOI Listing
March 2019
2 Reads

Lyme Neuroborreliosis - The Mystifying Pitfall: "Neuropathology and Current Therapeutics".

Recent Pat Antiinfect Drug Discov 2019 Mar 26. Epub 2019 Mar 26.

Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmadabad, Gujarat-382481. India.

Lyme's Disease (LD) is a severe rapidly growing broad spectrum chronic infection caused by the bacterium 'Borrelia (B.) burgdoferi', which can be easily transmitted through the bite of certain species of ticks. The prevalence of LD is swiftly mounting in present scenario in many countries from species to species. Read More

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http://dx.doi.org/10.2174/1574891X14666190327114641DOI Listing
March 2019
1 Read

Emerging and threatening vector-borne zoonoses in the world and in Europe: a brief update.

Authors:
Eva Jánová

Pathog Glob Health 2019 Mar 27:1-9. Epub 2019 Mar 27.

a Department of Animal Genetics, Faculty of Veterinary Medicine , University of Veterinary and Pharmaceutical Sciences , Brno , Czech Republic.

Climatic changes, landscape management, massive human, animal and commodity transportation represent important factors which are contributing to the spread of zoonotic diseases. The environmental and socioeconomic factors affecting the incidence of vector-borne zoonoses and possibilities for the reduction of disease impacts are discussed in the article. The most important zoonoses with expanding area of incidence and/or increasing occurrence are summarized, with special emphasis on the European region. Read More

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http://dx.doi.org/10.1080/20477724.2019.1598127DOI Listing
March 2019
1 Read

Genospecies of Borrelia burgdorferi sensu lato detected in 16 mammal species and questing ticks from northern Europe.

Sci Rep 2019 Mar 25;9(1):5088. Epub 2019 Mar 25.

Centre for Infectious Disease Control (CIb), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Lyme borreliosis is the most common vector-borne zoonosis in the northern hemisphere, and the pathogens causing Lyme borreliosis have distinct, incompletely described transmission cycles involving multiple host groups. The mammal community in Fennoscandia differs from continental Europe, and we have limited data on potential competent and incompetent hosts of the different genospecies of Borrelia burgdorferi sensu lato (sl) at the northern distribution ranges where Lyme borreliosis is emerging. We used qPCR to determine presence of B. Read More

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http://dx.doi.org/10.1038/s41598-019-41686-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434031PMC
March 2019
6 Reads

Tracking of transmission from infected nymphs to mice.

Infect Immun 2019 Mar 25. Epub 2019 Mar 25.

Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic

Quantitative and microscopic tracking of transmission from infected nymphs has shown transmission cycle different from and are abundant in the guts of unfed nymphs and their numbers continuously decrease during feeding. spirochetes are present in murine skin within 1 day of tick attachment. In contrast, spirochetes were not detectable in salivary glands at any stage of tick feeding. Read More

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http://dx.doi.org/10.1128/IAI.00896-18DOI Listing
March 2019
1 Read

Prevalence and Identification of Borrelia burgdorferi Sensu Lato Genospecies in Ticks from Northeastern China.

Vector Borne Zoonotic Dis 2019 Mar 23. Epub 2019 Mar 23.

2 Department of Animal Medicine, College of Life Sciences and Engineering, Foshan University, Foshan, Guangdong Province, China.

Lyme disease is considered as one of important tick-transmitted zoonosis in northeastern China, where the causative agents, the Borrelia burgdorferi sensu lato (s.l.) complex, remain poorly characterized. Read More

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http://dx.doi.org/10.1089/vbz.2018.2316DOI Listing
March 2019
3 Reads

Mice Against Ticks: an experimental community-guided effort to prevent tick-borne disease by altering the shared environment.

Philos Trans R Soc Lond B Biol Sci 2019 May;374(1772):20180105

1 MIT Media Lab , Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Mice Against Ticks is a community-guided ecological engineering project that aims to prevent tick-borne disease by using CRISPR-based genome editing to heritably immunize the white-footed mice ( Peromyscus leucopus) responsible for infecting many ticks in eastern North America. Introducing antibody-encoding resistance alleles into the local mouse population is anticipated to disrupt the disease transmission cycle for decades. Technology development is shaped by engagement with community members and visitors to the islands of Nantucket and Martha's Vineyard, including decisions at project inception about which types of disease resistance to pursue. Read More

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http://www.royalsocietypublishing.org/doi/10.1098/rstb.2018.
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http://dx.doi.org/10.1098/rstb.2018.0105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452264PMC
May 2019
8 Reads

A Rare Case of HIV-Induced Inflammatory Demyelinating Polyneuropathy.

Am J Med Case Rep 2019 21;7(1):5-8. Epub 2019 Jan 21.

Department of Medicine, SUNY Downstate Medical Center, 450 Clarkson Avenue Brooklyn, NY 11203 (718) 270-2030.

Background: Acute inflammatory demyelinating polyneuropathy (AIDP) is an uncommon form of neuropathy in HIV-infected patients that can cause pain, sensory disturbance, and motor weakness.

Case Presentation: A 23-year-old African American male with past medical history of Guillain-Barre Syndrome (GBS), Lyme disease, and sexually transmitted infections including syphilis and chlamydia presented with acute back pain radiating to bilateral lower extremities with worsening right foot weakness for four days. Cerebrospinal fluid (CSF) studies including meningoencephalitis panel were negative as well as blood tests for Lyme disease and HIV antibody testing. Read More

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http://dx.doi.org/10.12691/ajmcr-7-1-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424340PMC
January 2019
6 Reads

Presence of and Sensu Stricto in a Tick and Dual Parasitism of and on a Bird in Canada.

Healthcare (Basel) 2019 Mar 20;7(1). Epub 2019 Mar 20.

Department of Biology, Georgia Southern University, Statesboro, GA 30458, USA.

Wild birds transport ticks into Canada that harbor a diversity of zoonotic pathogens. However, medical practitioners often question how these zoonotic pathogens are present in their locality. In this study, we provide the first report of an tick cofeeding with a blacklegged tick, , which parasitized a Veery, -a neotropical songbird. Read More

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http://dx.doi.org/10.3390/healthcare7010046DOI Listing
March 2019
1 Read

Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes.

PLoS Pathog 2019 03 21;15(3):e1007659. Epub 2019 Mar 21.

Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Sciences Center, Bryan, Texas, United States of America.

The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we investigated the function of BBK32 orthologues of the Lyme-associated Borrelia burgdorferi sensu lato complex, designated BAD16 from B. afzelii strain PGau and BGD19 from B. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445466PMC
March 2019
1 Read

The effects of multiyear and seasonal weather factors on incidence of Lyme disease and its vector in New York State.

Sci Total Environ 2019 May 8;665:1182-1188. Epub 2019 Feb 8.

Department of Epidemiology and Biostatistics, University at Albany, State University at New York, Rensselaer, NY, United States of America; Investigations and Vector Surveillance Units, Bureau of Communicable Disease Control, New York State Department of Health, Albany, NY, United States of America.

Background: More frequent extreme weather and warmer weather due to climate change might change the spatiotemporal distributions of vector-borne diseases, including Lyme disease. However, limited studies have examined the associations of Lyme disease and its vectors with weather factors, especially multi-year and multi-weather factors related to vector life cycle.

Objectives: We investigated the associations between multi-year, unique weather indicators (relevant to tick and host activities) and Lyme disease incidence or documented I. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.123DOI Listing
May 2019
2 Reads

Epidemiology of Lyme borreliosis through two surveillance systems: the national Sentinelles GP network and the national hospital discharge database, France, 2005 to 2016.

Euro Surveill 2019 Mar;24(11)

Santé publique France, Paris, France.

Background: Lyme borreliosis (LB) is the most frequent vector-borne disease in France. Since 2009, surveillance of LB is conducted by a sentinel network of general practitioners (GPs). This system, in conjunction with the national hospitalisation database was used to estimate the incidence and describe the characteristics of LB in France. Read More

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https://www.eurosurveillance.org/content/10.2807/1560-7917.E
Publisher Site
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.11.1800134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425552PMC
March 2019
3 Reads

Organizing pneumonia co-existing with carcinoid tumour: complete resolution with bronchoscopic tumour resection.

Respirol Case Rep 2019 May 7;7(4):e00409. Epub 2019 Mar 7.

Pulmonary and Critical Care University of Maryland School of Medicine Baltimore MD USA.

Organizing pneumonia is a well-known clinical entity resulting in response to noxious stimuli causing lung injury. It is known to occur with infectious disease processes, neoplasms, post lung surgery or radiation therapy and when idiopathic, is called cryptogenic organizing pneumonia. We present an unusual case of a 48-year-old woman who presented with chronic cough and progressive dyspnoea while being on macrolide therapy for Lyme disease. Read More

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http://dx.doi.org/10.1002/rcr2.409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405329PMC
May 2019
1 Read

Lyme neuroborreliosis in children: Report of nine cases and a review of the literature.

Arch Pediatr 2019 Apr 15;26(3):133-137. Epub 2019 Mar 15.

Service de microbiologie, hôpital Necker-enfants-malades, Assistance publique-hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France.

Lyme neuroborreliosis is a bacterial infection caused by the dissemination and proliferation of a Borrelia species in the central nervous system. Neuroborreliosis occurs after transmission of the pathogen from an infected tick to a human host during a tick bite. We report nine cases of pediatric neuroborreliosis collected by the National Observatory of Pediatric Bacterial Meningitis in France between 2001 and 2012. Read More

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http://dx.doi.org/10.1016/j.arcped.2019.02.010DOI Listing
April 2019
1 Read

Analysis of a flagellar filament cap mutant reveals that HtrA serine protease degrades unfolded flagellin protein in the periplasm of Borrelia burgdorferi.

Mol Microbiol 2019 Mar 18. Epub 2019 Mar 18.

Philips Research Institute, Virginia Commonwealth University, Richmond, Virginia, 23298, USA.

Unlike external flagellated bacteria, spirochetes have periplasmic flagella (PF). Very little is known about how PF are assembled within the periplasm of spirochaetal cells. Herein, we report that FliD (BB0149), a flagellar cap protein (also named hook-associated protein 2), controls flagellin stability and flagellar filament assembly in the Lyme disease spirochete Borrelia burgdorferi. Read More

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http://dx.doi.org/10.1111/mmi.14243DOI Listing
March 2019
3 Reads
4.419 Impact Factor

Co-infections in Persons with Early Lyme Disease, New York, USA.

Emerg Infect Dis 2019 Apr;25(4):748-752

In certain regions of New York state, USA, Ixodes scapularis ticks can potentially transmit 4 pathogens in addition to Borrelia burgdorferi: Anaplasma phagocytophilum, Babesia microti, Borrelia miyamotoi, and the deer tick virus subtype of Powassan virus. In a prospective study, we systematically evaluated 52 adult patients with erythema migrans, the most common clinical manifestation of B. burgdorferi infection (Lyme disease), who had not received treatment for Lyme disease. Read More

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http://dx.doi.org/10.3201/eid2504.181509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433014PMC
April 2019
1 Read

Evaluation and Management of Septic Arthritis and its Mimics in the Emergency Department.

West J Emerg Med 2019 Mar 6;20(2):331-341. Epub 2018 Dec 6.

Rush University Medical Center, Department of Emergency Medicine, Chicago, Illinois.

Septic arthritis is a dangerous medical condition associated with significant morbidity and mortality. However, the differential diagnosis can be broad with conditions that mimic this disease and require different evaluation and treatment. This narrative review presents the emergency medicine evaluation and management, as well as important medical conditions that may mimic this disease. Read More

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http://dx.doi.org/10.5811/westjem.2018.10.40974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404712PMC
March 2019
1 Read

Borrelia outer surface protein C is capable of human fibrinogen binding.

FEBS J 2019 Mar 15. Epub 2019 Mar 15.

Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.

Outer surface protein C (OspC) is one of the most abundant surface lipoproteins produced during early infection by the Borrelia spirochete, the causative agent of Lyme disease. The high sequence variability of the ospC gene results in the production of several and strongly divergent OspC types. One of the known roles of OspC is the recruitment of blood components, including complement regulators, to facilitate the bloodstream survival of Borrelia at an essential stage of host infection. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/febs.14810
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http://dx.doi.org/10.1111/febs.14810DOI Listing
March 2019
5 Reads

Lyme Disease Patient Trajectories Learned from Electronic Medical Data for Stratification of Disease Risk and Therapeutic Response.

Sci Rep 2019 Mar 14;9(1):4460. Epub 2019 Mar 14.

Department of Genetics and Genomic Sciences, Institute for Next Generation Healthcare, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1498, New York, NY, 10029, USA.

Lyme disease (LD) is the most common tick-borne illness in the United States. Although appropriate antibiotic treatment is effective for most cases, up to 20% of patients develop post-treatment Lyme disease syndrome (PTLDS). There is an urgent need to improve clinical management of LD using precise understanding of disease and patient stratification. Read More

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http://dx.doi.org/10.1038/s41598-019-41128-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418311PMC
March 2019
1 Read
5.078 Impact Factor

[Suspicion of chronic Lyme disease: must we give in to antibiotic climbing?]

Authors:
Yves Hansmann

Rev Prat 2018 Nov;68(9):946-948

Service des maladies infectieuses et tropicales, Hôpitaux universitaires de Strasbourg, Strasbourg, France.

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November 2018

Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1.

Int J Gen Med 2019 18;12:101-119. Epub 2019 Feb 18.

Hudson Valley Healing Arts Center, Hyde Park, NY 12538, USA,

Purpose: We collected data from an online survey of 200 of our patients, which evaluated the efficacy of dapsone (diaminodiphenyl sulfone, ie, DDS) combined with other antibiotics and agents that disrupt biofilms for the treatment of chronic Lyme disease/post-treatment Lyme disease syndrome (PTLDS). We also collected aggregate data from direct retrospective chart review, including laboratory testing for Lyme, other infections, and associated tick-borne coinfections. This helped us to determine the frequency of exposure to other infections/coinfections among a cohort of chronically ill Lyme patients, evaluate the efficacy of newer "persister" drug regimens like DDS, and determine how other infections and tick-borne coinfections may be contributing to the burden of chronic illness leading to resistant symptomatology. Read More

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http://dx.doi.org/10.2147/IJGM.S193608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388746PMC
February 2019
2 Reads

Sjögren's syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease.

Reumatologia 2019 28;57(1):59-62. Epub 2019 Feb 28.

Department of Surgical Dentistry, Ivan Horbachevsky Ternopil State Medical University, Ukraine.

Lyme disease is a multisystem tick-borne transmissive disease with heterogeneous manifestations, frequently making the diagnosis difficult in clinical practice. Herein, we report a case of a 43-year-old female patient who presented with generalized lymphadenopathy requiring a further diagnostic evaluation towards lymphoma. The patient also had clinical signs of Sjögren's syndrome. Read More

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http://dx.doi.org/10.5114/reum.2019.83242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409830PMC
February 2019
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CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells.

Eur J Immunol 2019 Mar 10. Epub 2019 Mar 10.

Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Lyme disease is a common multisystem disease caused by infection with a tick-transmitted spirochete, Borrelia burgdorferi and related Borrelia species. The monoglycosylated diacylglycerol known as B. burgdorferi glycolipid II (BbGL-II) is a major target of antibodies in sera from infected individuals. Read More

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http://dx.doi.org/10.1002/eji.201847949DOI Listing
March 2019
4 Reads

A minority of children diagnosed with Lyme disease recall a preceding tick bite.

Ticks Tick Borne Dis 2019 04 26;10(3):694-696. Epub 2019 Feb 26.

Division of Emergency Medicine, Rhode Island Hospital, Providence, RI, United States.

Of 1770 children undergoing emergency department evaluation for Lyme disease, 362 (20.5%) children had Lyme disease. Of those with an available tick bite history, only a minority of those with Lyme disease had a recognized tick bite (60/325; 18. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.02.015DOI Listing
April 2019
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Vertical transmission rates of Borrelia miyamotoi in Ixodes scapularis collected from white-tailed deer.

Ticks Tick Borne Dis 2019 04 26;10(3):682-689. Epub 2019 Feb 26.

Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, 48824, United States; Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, 48824, United States. Electronic address:

Borrelia miyamotoi is a relapsing fever spirochete transmitted by ticks in the Ixodes ricinus complex. In the eastern United States, B. miyamotoi is transmitted by I. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.02.014DOI Listing
April 2019
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Early Disseminated Lyme Disease in a 15-Year-Old Male.

J Cutan Med Surg 2019 Mar/Apr;23(2):222

2 Department of Medicine, Division of Clinical Dermatology & Cutaneous Science, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.

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http://dx.doi.org/10.1177/1203475418791995DOI Listing
March 2019
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Latent Lyme Disease Resulting in Chronic Arthritis and Early Career Termination in a United States Army Officer.

Mil Med 2019 Mar 6. Epub 2019 Mar 6.

Department of Chemistry and Life Science, Bartlett Hall, 753 Cullum Road, West Point, NY.

Lyme disease is a continuing threat to military personnel operating in arboriferous and mountainous environments. Here we present the case of a 24-year-old Second Lieutenant, a recent graduate from the United States Military Academy, with a history of Lyme disease who developed recurrent knee effusions following surgery to correct a hip impingement. Although gonococcal arthritis was initially suspected from preliminary laboratory results, a comprehensive evaluation contradicted this diagnosis. Read More

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http://dx.doi.org/10.1093/milmed/usz026DOI Listing
March 2019
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Geographic Range of Lyme Borreliosis in Mongolia.

Vector Borne Zoonotic Dis 2019 Mar 5. Epub 2019 Mar 5.

2 National Center for Zoonotic Diseases, Ulaanbaatar, Mongolia.

Introduction: In Asia, Borrelia garinii, B. afzelii, and B. bavariensis are transmitted by Ixodes persulcatus ticks and clinically present with a wide range of neurological and arthritic symptoms. Read More

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http://dx.doi.org/10.1089/vbz.2018.2421DOI Listing
March 2019
6 Reads

[A "new" look at "old" borreliosis].

Authors:
Tadeusz Płusa

Pol Merkur Lekarski 2019 Feb;46(272):55-59

Medical Faculty of Łazarski University in Warsaw.

The threat of borreliosis is a growing medical problem. The number of cases is constantly increasing, and the diagnostic methods and recommended treatment methods do not bring new values in comparison to the findings from over 30 years ago. Among the pathogens transmitted by ticks, apart from Borrelia burgdorferi, Anaplasma phagocytophilum, Babesia species, Neoehrlichia mikurensis, as well as fever caused by rickettsiae and others, are referred to as "emerging" or "rediscovered". Read More

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February 2019
7 Reads

Detection of antibodies to Borrelia burgdorferi s.l. in wild small mammals and sensitivity of PCR and cultivation.

Vet Microbiol 2019 Mar 4;230:241-243. Epub 2019 Feb 4.

Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, 612 42 Brno, Czech Republic. Electronic address:

The aim of this study was to determine the seroprevalence of antibodies to B. burgdorferi s.l. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.02.004DOI Listing
March 2019
4 Reads