13,369 results match your criteria Lyme Disease


A tick beat in the electrocardiogram: Persistent third degree block as only manifestation of Lyme disease.

J Electrocardiol 2018 Dec 6;52:109-111. Epub 2018 Dec 6.

Internal Medicine Department, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Lyme disease is the most common tick-borne illness in North America. A 23-year-old female presented to our emergency department with a chief complaint of sudden dyspnea and chest pain. An electrocardiogram revealed a third degree heart block. Read More

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December 2018

Interferon-gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast-like synoviocytes into immune effector cells.

Cell Microbiol 2018 Dec 14:e12992. Epub 2018 Dec 14.

Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy, & Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Lyme arthritis (LA), a late disease manifestation of Borrelia burgdorferi infection, usually resolves with antibiotic therapy. However, some patients develop proliferative synovitis lasting months to several years after spirochetal killing, called post-infectious LA. In this study, we phenotyped hematopoietic and stromal cell populations in the synovial lesion ex vivo and used these findings to generate an in vitro model of LA using patient-derived fibroblast-like synoviocytes (FLS). Read More

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December 2018

Host-specific expression of Ixodes scapularis salivary genes.

Ticks Tick Borne Dis 2018 Dec 3. Epub 2018 Dec 3.

Section of Infectious Diseases, New Haven, CT, 06520, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland, 20815, USA.

Ixodes scapularis vectors several pathogens including Borrelia burgdorferi, the agent of Lyme disease. Nymphal and larval stages, and the pathogens transmitted by I. scapularis are maintained in a zoonotic cycle involving rodent reservoir hosts, predominantly Peromyscus leucopus. Read More

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December 2018

Lyme neuroborreliosis- clinical outcomes, controversy, pathogenesis, and polymicrobial infections.

Ann Neurol 2018 Dec 10. Epub 2018 Dec 10.

Department of Molecular Genetics and Microbiology and Pathology, Stony Brook University School of Medicine, Stony Brook, NY, USA.

Lyme Borreliosis is the object of numerous misconceptions. In this review, we revisit the fundamental manifestations of neuroborreliosis (meningitis and cranial and radiculoneuritis) as these have withstood the test of time. We also discuss other manifestations that are less frequent. Read More

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December 2018

Review of European and American guidelines for the diagnosis of Lyme borreliosis.

Med Mal Infect 2018 Dec 6. Epub 2018 Dec 6.

Aix Marseille université, IRD, SSA, VITROME, IHU-Méditerranée Infection, AP-HM, 13005 Marseille, France.

Lyme disease is a tick-borne bacterial disease with polymorphic clinical manifestations (cutaneous, rheumatological, and neurological). In recent years the issue of the diagnosis of this infection has been highly publicized on the Internet and other media in Europe and America. Some patients and physicians may share the perception that the diagnosis of the infection is not reliable in France. Read More

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December 2018
1 Read

Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques.

Clin Cosmet Investig Dermatol 2018 9;11:561-569. Epub 2018 Nov 9.

IGeneX Laboratories, Palo Alto, CA, USA.

Background: Morgellons disease (MD) is a skin condition associated with Lyme disease (LD) and tick-borne illness. Patients with this skin disorder experience ulcerative lesions that contain multicolored filamentous collagen and keratin inclusions. Infection with various species of and other tick-borne pathogens has been detected in tissue and body fluid specimens from MD patients. Read More

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November 2018
3 Reads

Biologic Markers of Antibiotic-Refractory Lyme Arthritis in Human: A Systematic Review.

Infect Dis Ther 2018 Nov 30. Epub 2018 Nov 30.

Cumming School of Medicine, University of Calgary, Calgary, Canada.

Introduction: Lyme disease-also known as Lyme borreliosis (LB)-is the most common vector-borne disease in North America and Europe. It may result in substantial morbidity, primarily from persistent Lyme arthritis (LA) that-although treatable-can develop into antibiotic-refractory LA (A-RLA). The aim of this study is to systematically review and evaluate a range of biomarkers for their potential predictive value in the development of A-RLA. Read More

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November 2018
3 Reads

Landscape structure affects the prevalence and distribution of a tick-borne zoonotic pathogen.

Parasit Vectors 2018 Dec 4;11(1):621. Epub 2018 Dec 4.

Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, Scotland, UK.

Background: Landscape structure can affect pathogen prevalence and persistence with consequences for human and animal health. Few studies have examined how reservoir host species traits may interact with landscape structure to alter pathogen communities and dynamics. Using a landscape of islands and mainland sites we investigated how natural landscape fragmentation affects the prevalence and persistence of the zoonotic tick-borne pathogen complex Borrelia burgdorferi (sensu lato), which causes Lyme borreliosis. Read More

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December 2018
1 Read

An updated meta-analysis of the distribution and prevalence of Borrelia burgdorferi s.l. in ticks in Europe.

Int J Health Geogr 2018 Dec 4;17(1):41. Epub 2018 Dec 4.

Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, Romania.

Background: The bacteria of the group Borrelia burgdorferi s.l. are the etiological agents of Lyme borreliosis in humans, transmitted by bites of ticks. Read More

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December 2018
3 Reads

Clinical Course, Serologic Response, and Long-Term Outcome in Elderly Patients with Early Lyme Borreliosis.

J Clin Med 2018 Dec 2;7(12). Epub 2018 Dec 2.

Department of Infectious Diseases, University Medical Center Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.

Infected elderly people often present with signs and symptoms that differ from those in younger adults, but data on the association between patient age and presentation of early Lyme borreliosis (LB) are limited. In this study, the association between patient age (18⁻44 years, young vs. 45⁻64 years, middle-aged vs. Read More

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December 2018
3 Reads

Efficacy of Borrelia burgdorferi vaccine in dogs in North America: A systematic review and meta-analysis.

J Vet Intern Med 2018 Dec 3. Epub 2018 Dec 3.

Research and Scholarship Team, McLaughlin Library, University of Guelph, Guelph, Ontario, Canada.

Background: Lyme borreliosis, a tick-borne disease, is endemic to some parts of North America and is an emerging disease in other parts of the world. Vaccination is an increasingly common, although controversial, method used in the prevention of Lyme disease in dogs; the reported efficacies of Borrelia burgdorferi vaccines in dogs are highly variable, ranging from 50% to 100%.

Objectives: To determine the efficacy of vaccines for prevention of Lyme disease in dogs in North America. Read More

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December 2018
2 Reads

Downregulation of the central noradrenergic system by infection.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

School of Biology, Faculty of Biological Sciences, Clarendon Way, University of Leeds, Leeds LS2 9JT, UK

is associated with physiological effects in the host. Dysregulation of catecholamines in the central nervous system has previously been observed in chronically-infected animals. In the study described here, the noradrenergic system was found to be suppressed with decreased levels of norepinephrine (NE) in brains of infected animals and in infected human and rat neural cells The mechanism responsible for the NE suppression was found to be down-regulation of dopamine β-hydroxylase (DBH) gene expression, encoding the enzyme that synthesizes norepinephrine from dopamine with down-regulation observed and in infected brain tissue, particularly in the dorsal locus coeruleus/pons region. Read More

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December 2018
4 Reads

Borreliosis-associated orofacial pain: A case report

Swiss Dent J 2018 12(12):969-973

Universitätsklinik für Schädel-, Kiefer- und Gesichtschirurgie, Inselspital, Universitätsspital Bern

Lyme borreliosis is a prevalent disease with a wide variety of clinical manifestations. However, only a few pertinent references are found in the dental literature. Considering the diversity of differential diagnoses, borreliosis-associated orofacial pain may be a challenge for treatment providers and patients alike. Read More

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December 2018
1 Read

Multistate Infestation with the Exotic Disease-Vector Tick Haemaphysalis longicornis - United States, August 2017-September 2018.

MMWR Morb Mortal Wkly Rep 2018 Nov 30;67(47):1310-1313. Epub 2018 Nov 30.

Haemaphysalis longicornis is a tick indigenous to eastern Asia and an important vector of human and animal disease agents, resulting in such outcomes as human hemorrhagic fever and reduction of production in dairy cattle by 25%. H. longicornis was discovered on a sheep in New Jersey in August 2017 (1). Read More

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November 2018
3 Reads

The relapsing fever spirochete Borrelia turicatae persists in the highly oxidative environment of its soft-bodied tick vector.

Cell Microbiol 2018 Nov 29:e12987. Epub 2018 Nov 29.

Departments of Pediatrics and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America.

The relapsing fever spirochete Borrelia turicatae possesses a complex life cycle in its soft-bodied tick vector, Ornithodoros turicata. Spirochetes enter the tick midgut during a bloodmeal, and during the following weeks spirochetes disseminate throughout O. turicata. Read More

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November 2018
1 Read

DksA controls the response of the Lyme disease spirochete to starvation.

J Bacteriol 2018 Nov 26. Epub 2018 Nov 26.

Department of Medical Microbiology and Immunology, Creighton University, Omaha, NE, United States.

The pathogenic spirochete senses and responds to changes in the environment, including changes in nutrient availability, throughout its enzootic cycle in ticks and vertebrate hosts. This study examined the role of DnaK suppressor protein (DksA) in the transcriptional response of to starvation. Wild-type and mutant strains were subjected to starvation by shifting cultures grown in rich complete medium, BSK II, to a defined mammalian tissue culture medium, RPMI 1640, for 6 h under microaerobic conditions (5% CO, 3% O). Read More

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November 2018
6 Reads

Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice.

J Infect Dis 2018 Nov 21. Epub 2018 Nov 21.

MassBiologics of University of Massachusetts Medical School, Boston.

We recently developed anti-OspA human immunoglobulin G1 monoclonal antibodies (HuMAbs) that are effective in preventing Borrelia transmission from ticks in a murine model. Here, we investigated a novel approach of DNA-mediated gene transfer of HuMAbs that provide protection against Lyme disease. Plasmid DNA-encoded anti-OspA HuMAbs inoculated in mice achieved a serum antibody concentration of >6 μg/mL. Read More

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November 2018
1 Read

"Ticking Bomb": The Impact of Climate Change on the Incidence of Lyme Disease.

Can J Infect Dis Med Microbiol 2018 24;2018:5719081. Epub 2018 Oct 24.

Carnegie Mellon University, Heinz College, 4800 Forbes Ave., Pittsburgh, PA, USA.

Lyme disease (LD) is the most common tick-borne disease in North America. It is caused by and transmitted to humans by blacklegged ticks, The life cycle of the LD vector, , usually takes two to three years to complete and goes through three stages, all of which are dependent on environmental factors. Increases in daily average temperatures, a manifestation of climate change, might have contributed to an increase in tick abundance via higher rates of tick survival. Read More

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October 2018
3 Reads

Convenient synthesis of the immunogenic glycolipid BbGL1.

Steroids 2018 Nov 22;141:41-45. Epub 2018 Nov 22.

Instituto de Química Rosario (IQUIR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina. Electronic address:

A simple and efficient method to synthesize the immunogenic glycolipid BbGL1 is introduced. Two simple steps were required to obtain the desired product in good yield. First, a highly efficient glycosylation of cholesterol using galactosyl trichloroacetimidate as a donor was performed to produce cholesteryl-β-d-galactoside. Read More

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November 2018
1 Read

Letter to the editor on "Suspicious Index in Lyme Carditis (SILC): Systematic review and proposed new risk score".

Clin Cardiol 2018 Nov 22. Epub 2018 Nov 22.

Clinical Research Scientist and Consultant, ScientificWriting Corp, Houston, Texas.

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November 2018
2 Reads

Suspicious index in Lyme carditis: Construction of a new risk model in the absence of guidelines.

Clin Cardiol 2018 Nov 22. Epub 2018 Nov 22.

Division of Cardiology, Kingston Health Science Centre, Queen's University, Kingston, Ontario, Canada.

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November 2018
3 Reads

Risk factors associated with the carriage of Ixodes scapularis relative to other tick species in a population of pet dogs from southeastern Ontario, Canada.

Ticks Tick Borne Dis 2018 Oct 17. Epub 2018 Oct 17.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2WI, Canada; Canadian Wildlife Health Cooperative, Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2WI, Canada. Electronic address:

In eastern North America, the blacklegged tick, Ixodes scapularis, is the vector for Borrelia burgdorferi sensu stricto and Anaplasma phagocytophilum, the causal agents for human and canine Lyme disease and anaplasmosis, respectively. The extensive range expansion of I. scapularis in Ontario is a growing veterinary and public health concern. Read More

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October 2018
2 Reads

Passage of Borrelia burgdorferi through diverse Ixodid hard ticks causes distinct diseases: Lyme borreliosis and Baggio-Yoshinari syndrome.

Clinics (Sao Paulo) 2018 Nov 14;73:e394. Epub 2018 Nov 14.

Reumatologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Baggio-Yoshinari syndrome is an emerging, tick-borne, infectious disease recently discovered in Brazil. This syndrome is similar to Lyme disease, which is common in the United States of America, Europe and Asia; however, Brazilian borreliosis diverges from the disease observed in the Northern Hemisphere in its epidemiological, microbiological, laboratory and clinical characteristics. Polymerase chain reaction procedures showed that Baggio-Yoshinari syndrome is caused by the Borrelia burgdorferi sensu stricto spirochete. Read More

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November 2018
9 Reads

Holistic or Dedicated Approach in Lyme Disease?

Clin Infect Dis 2018 Nov 21. Epub 2018 Nov 21.

Infectious Diseases Unit, University Hospital Raymond Poincaré, APHP Versailles Saint Quentin University GARCHES, France.

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November 2018
1 Read

Consultation for presumed Lyme borreliosis: the need for a multidisciplinary management.

Clin Infect Dis 2018 Nov 21. Epub 2018 Nov 21.

Service de Maladies Infectieuses, CHU Besancon, France.

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November 2018
1 Read

Septic arthritis of the pediatric hip: update on diagnosis and treatment.

Curr Opin Pediatr 2018 Nov 16. Epub 2018 Nov 16.

Department of Orthopaedics, Medical University of South Carolina, Charleston, South Carolina, USA.

Purpose Of Review: To review the clinical diagnosis, management and natural history of septic arthritis of the hip (SAH) in the pediatric patient, and to highlight new information that may improve the management of these patients.

Recent Findings: The basics of management of possible pediatric SAH have remained largely unchanged for generations. New questions have been raised regarding the role and timing of advanced imaging (MRI) in the evaluation of patients with possible SAH. Read More

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November 2018
4 Reads

The Controversies, Challenges and Complexities of Lyme Disease: A Narrative Review.

J Pharm Pharm Sci 2018 ;21(1):429-436

Public Health Institute, Liverpool John Moore's University, Liverpool L32ET, United Kingdom.

Purpose: Lyme disease has become an increasingly important global public health concern.

Method: A narrative review was conducted and designed to present a broad perspective on Lyme disease, and describe its history and development in terms of clinical care and public health implications. A structured literature search was conducted based on the question; what is currently known about Lyme disease?

Results: The narrative review is presented in chronological order in terms of a summary of the history of Lyme disease, the complexities of clinical diagnosis, the problematic interpretation of serologic testing, the conflicting guidelines for diagnosis, treatment and management of chronic Lyme, and benefits of antibiotic treatment. Read More

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January 2018
1 Read

Clinical spectrum of Lyme disease.

Eur J Clin Microbiol Infect Dis 2018 Nov 19. Epub 2018 Nov 19.

University Hospital "Dr. Jose Eleuterio Gonzalez", Department of Dermatology, Universidad Autonoma de Nuevo Leon, Av. Madero y Gonzalitos s/n, Colonia Mitras Centro, 64460, Monterrey, NL, Mexico.

Lyme disease (borreliosis) is one of the most common vector-borne diseases worldwide. Its incidence and geographic expansion has been steadily increasing in the last decades. Lyme disease is caused by Borrelia burgdorferi sensu lato, a heterogeneous group of which three genospecies have been systematically associated to Lyme disease: B. Read More

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November 2018
5 Reads

Interventions to prevent Lyme disease in humans: A systematic review.

Prev Med Rep 2019 Mar 13;13:16-22. Epub 2018 Nov 13.

EPPI-Centre, UCL Institute of Education, University College London, London, UK.

Lyme disease (LD) is an infection transferred to humans through bites from infected ticks. Surveillance indicates that the number of LD cases is increasing in the UK, therefore, improved knowledge about reducing transmission from ticks to humans is needed. Eighteen electronic databases were searched and additional web-based searching was conducted, to locate empirical research, published from 2002 onwards. Read More

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March 2019
8 Reads

Climate impacts on blacklegged tick host-seeking behavior.

Int J Parasitol 2018 Nov 15. Epub 2018 Nov 15.

Department of Ecology, Evolution, and Environmental Biology, Columbia University, New York City, NY 10027, USA. Electronic address:

The nymph of the blacklegged tick (Ixodes scapularis), the primary North American vector of the causative agent of Lyme disease, must attach to a host by the end of its questing season in order to feed and subsequently molt into an adult. The proper timing of this behavior is critical both for the tick's survival and for perpetuating the transmission of tick-borne pathogens. Questing also depletes limited nymphal lipid reserves and increases desiccation risk. Read More

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November 2018
2 Reads

Can Google Trends data improve forecasting of Lyme disease incidence?

Zoonoses Public Health 2018 Nov 16. Epub 2018 Nov 16.

Department of Neurology and Stroke, Neurology Clinics, Eberhard Karls University, Tübingen, Germany.

Background: Online activity-based epidemiological surveillance and forecasting is getting more and more attention. To date, Google search volumes have not been assessed for forecasting of tick-borne diseases. Thus, we performed an analysis of forecasting of the Lyme disease incidence based on the traditional data extended with Google Trends. Read More

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November 2018
3 Reads

High burdens of Ixodes scapularis larval ticks on white-tailed deer may limit Lyme disease risk in a low biodiversity setting.

Ticks Tick Borne Dis 2018 Nov 3. Epub 2018 Nov 3.

Department of Ecology, Evolution, and Environmental Biology, Columbia University, 1200 Amsterdam Ave., 10027 New York, NY, United States. Electronic address:

An inverse relationship between biodiversity and human health has been termed the 'dilution effect' paradigm. In the case of tick-borne infections such as Lyme disease, the key assumption is that Borrelia burgdorferi sensu lato abundance is increased by the loss of less competent (dilution) hosts as biodiversity declines. White-tailed deer play a dual role in the pathogen cycle, as key reproductive hosts for adult ticks and incompetent hosts for the pathogen. Read More

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November 2018
7 Reads

Delusional infestation versus Morgellons disease.

Clin Dermatol 2018 Nov - Dec;36(6):714-718. Epub 2018 Aug 16.

University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Delusional infestation is the conviction that one is infested with pathogens-either animate or inanimate-despite medical or microbiologic evidence to the contrary. Infestation with inanimate pathogens, specifically fibers or filaments, has been controversially termed Morgellons disease by the patients themselves, who believe that this is not a psychiatric disease but rather a new organic condition or a skin manifestation of an infection, such as Lyme disease. A large-scale study by the Centers of Disease Control and Prevention on patients presenting with Morgellons clinical manifestations did not find evidence of fibers in the skin nor an association with any infection, including Lyme disease. Read More

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August 2018
2 Reads

basic membrane protein A stimulates murine macrophage to secrete specific chemokines.

Int J Med Sci 2018 2;15(13):1473-1479. Epub 2018 Oct 2.

Department of Microbiology and Immunology, Kunming Medical University, Kunming 650500, China.

In this study, we investigated the mechanisms that lead to the production of proinflammatory mediators by the murine macrophage cell line, RAW264.7, when these cells are exposed in vitro to recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). Using antibody protein microarray technology with high-throughput detection ability for detecting 25 chemokines in culture supernatant the RAW264. Read More

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October 2018
8 Reads

Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis.

Postepy Dermatol Alergol 2018 Oct 19;35(5):490-494. Epub 2018 Jul 19.

Department of Infectious Diseases and Neuroinfections, Medical University of Białystok, Białystok, Poland.

Introduction: Acrodermatitis chronica atrophicans (ACA) is probably the most common late and chronic manifestation of the Lyme borreliosis seen in European patients.

Aim: To analyze epidemiological data, and to investigate the effects of treatment of patients with ACA.

Material And Methods: Nine patients were included in the study. Read More

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October 2018
4 Reads

Characterization of tick organic anion transporting polypeptides (OATPs) upon bacterial and viral infections.

Parasit Vectors 2018 Nov 14;11(1):593. Epub 2018 Nov 14.

Department of Biological Sciences, Old Dominion University, Norfolk, VA, USA.

Background: Ixodes scapularis organic anion transporting polypeptides (OATPs) play important roles in tick-rickettsial pathogen interactions. In this report, we characterized the role of these conserved molecules in ticks infected with either Lyme disease agent Borrelia burgdorferi or tick-borne Langat virus (LGTV), a pathogen closely related to tick-borne encephalitis virus (TBEV).

Results: Quantitative real-time polymerase chain reaction analysis revealed no significant changes in oatps gene expression upon infection with B. Read More

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November 2018
2 Reads
3.430 Impact Factor

A 15-Year-Old Male With Wide Complex Tachyarrhythmia.

Air Med J 2018 Nov - Dec;37(6):383-387. Epub 2018 Sep 1.

Department of Emergency Medicine, Allegheny General Hospital, Pittsburgh, PA.

A 15-year-old male presented with exertional syncope and was found to be in an unstable regular wide complex tachyarrhythmia (WCT). After a trial of antiarrhythmic medication, his clinical condition declined, necessitating synchronized cardioversion. Although he noted symptomatic improvement after cardioversion, he was found to be in third-degree heart block. Read More

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September 2018
4 Reads

Acoustic inversion for Monin-Obukhov similarity parameters from wind noise in a convective boundary layer.

J Acoust Soc Am 2018 Sep;144(3):1258

U.S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory, 2902 Newmark Drive, Champaign, Illinois 61822-1076, USA.

The prediction accuracy of outdoor sound is in large part limited by uncertainties in the state of the atmosphere. These uncertainties can potentially be reduced by inferring scaling parameters of the atmospheric surface layer from wind noise. Screened microphones sense wind noise as a result of mean atmospheric flow, turbulent eddy interaction with the windscreen, and pressure fluctuations within the turbulent flow. Read More

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September 2018
1 Read

Extensive Distribution of the Lyme Disease Bacterium, Sensu Lato, in Multiple Tick Species Parasitizing Avian and Mammalian Hosts across Canada.

Healthcare (Basel) 2018 Nov 12;6(4). Epub 2018 Nov 12.

Department of Biology, Georgia Southern University, Statesboro, GA 30458, USA.

Lyme disease, caused by the spirochetal bacterium, sensu lato (Bbsl), is typically transmitted by hard-bodied ticks (Acari: Ixodidae). Whenever this tick-borne zoonosis is mentioned in medical clinics and emergency rooms, it sparks a firestorm of controversy. Denial often sets in, and healthcare practitioners dismiss the fact that this pathogenic spirochetosis is present in their area. Read More

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November 2018
2 Reads

Core genome phylogenetic analysis of the avian associated Borrelia turdi indicates a close relationship to Borrelia garinii.

Mol Phylogenet Evol 2018 Nov 10;131:93-98. Epub 2018 Nov 10.

National Institute of Health Dr. Ricardo Jorge, Infectious Department, Lisbon, Portugal; MARE - Marine and Environmental Sciences Centre, Department of Life Sciences, Largo Marquês de Pombal, Faculty of Sciences and Technology, University of Coimbra, Portugal.

Borrelia burgdorferi sensu lato comprises a species complex of tick-transmitted bacteria that includes the agents of human Lyme borreliosis. Borrelia turdi is a genospecies of this complex that exists in cryptic transmission cycles mainly between ornithophilic tick vectors and their avian hosts. The species has been originally discovered in avian transmission cycles in Asia but has increasingly been found in Europe. Read More

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November 2018
14 Reads

Of Old Lyme, ticks, and new Borrelia.

Travel Med Infect Dis 2018 Nov - Dec;26:74. Epub 2018 Nov 10.

Medizinische Fakultät, Departement Klinische Forschung (DKF), Emeritus, Departement Klinische Medizin, Ksp. 1, 7.St.W, Spitalstrasse 21, 4031 Basel CH, Switzerland. Electronic address:

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November 2018
1 Read

Epidemiology of Lyme disease in Pennsylvania 2006-2014 using electronic health records.

Ticks Tick Borne Dis 2018 Oct 26. Epub 2018 Oct 26.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology and Health Services Research, Geisinger, Danville, PA, USA; Johns Hopkins School of Medicine, Department of Medicine, Baltimore, MD, USA. Electronic address:

Lyme disease is the most common vector-borne disease in the United States. Electronic health record (EHR)-based research on Lyme disease is limited. We used Geisinger EHR data from 479,344 primary care patients in 38 Pennsylvania counties in 2006-2014 to compare EHR-based Lyme disease incidence rates to surveillance incidence rates, evaluate individual and community risk factors for incident Lyme disease, and to characterize the proportion of cases with diagnoses consistent with post-treatment Lyme disease syndrome in the EHR (PTLDS). Read More

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October 2018
8 Reads

Predicting the ligand-binding properties of Borrelia burgdorferi s.s. Bmp proteins in light of the conserved features of related Borrelia proteins.

J Theor Biol 2018 Nov 9;462:97-108. Epub 2018 Nov 9.

Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6 A, Turku FI-20520, Finland. Electronic address:

Bacteria of the genus Borrelia cause vector-borne infections like the most important hard tick-borne disease in the northern hemisphere, Lyme borreliosis (LB), and soft tick or louse transmitted relapsing fevers (RF), prevalent in temperate and tropical areas. Borrelia burgdorferi sensu lato (s.l. Read More

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November 2018
7 Reads

A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn.

PLoS One 2018 12;13(11):e0207067. Epub 2018 Nov 12.

National Microbiology Laboratory, Public Health Agency of Canada, Saint-Hyacinthe, Quebec, Canada.

Lyme disease (LD), caused by bacteria of the Borrelia burgdorferi sensu lato species complex, is the most common vector-borne disease in North America and Europe. A systematic review (SR) was conducted to summarize the global literature on adverse birth outcomes associated with gestational LD in humans. The SR followed an a priori protocol of pretested screening, risk of bias, and data extraction forms. Read More

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November 2018
3 Reads

Neurocognition in Post-Treatment Lyme Disease and Major Depressive Disorder.

Arch Clin Neuropsychol 2018 Nov 12. Epub 2018 Nov 12.

Lyme Disease Research Center, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Objective: Neurocognitive dysfunction in patients with residual or emergent symptoms after treatment for Lyme Disease is often attributed to comorbid depression. In this study, patients with Post-Treatment Lyme Disease Syndrome (PTLDS) were compared to patients with Major Depressive Disorder (MDD), as well as healthy comparison subjects (HC), on neurocognitive measures administered through the same laboratory, to determine if patterns of performance were similar.

Methods: Two analyses were conducted. Read More

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November 2018
19 Reads

Cryo-electron tomography of periplasmic flagella in Borrelia burgdorferi reveals a distinct cytoplasmic ATPase complex.

PLoS Biol 2018 Nov 9;16(11):e3000050. Epub 2018 Nov 9.

Department of Microbial Pathogenesis, Microbial Sciences Institute, Yale University, New Haven, Connecticut, United States of America.

Periplasmic flagella are essential for the distinct morphology and motility of spirochetes. A flagella-specific type III secretion system (fT3SS) composed of a membrane-bound export apparatus and a cytosolic ATPase complex is responsible for the assembly of the periplasmic flagella. Here, we deployed cryo-electron tomography (cryo-ET) to visualize the fT3SS machine in the Lyme disease spirochete Borrelia burgdorferi. Read More

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November 2018
2 Reads

dtangle: accurate and robust cell type deconvolution.

Bioinformatics 2018 Nov 8. Epub 2018 Nov 8.

Department of Statistics, University of Michigan, 311 West Hall 1085 South University Ann Arbor, Michigan, United States of America.

Motivation: Cell type composition of tissues is important in many biological processes. To help understand cell type composition using gene expression data, methods of estimating (deconvolving) cell type proportions have been developed. Such estimates are often used to adjust for confounding effects of cell type in differential expression analysis (DEA). Read More

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November 2018
3 Reads

Extensive Diversity of RNA Viruses in Australian Ticks.

J Virol 2018 Nov 7. Epub 2018 Nov 7.

Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia.

Understanding the microbiome of ticks in Australia is of considerable interest given the ongoing debate over whether Lyme disease, and its causative agent the bacterium sensu lato, are present in Australia. The diversity of bacteria infecting Australian ticks has been studied using both culture and metagenomics based techniques. However, little is known about the virome of Australian ticks, including whether this includes viruses with the potential to infect mammals. Read More

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November 2018
7 Reads

Efficient prediction of acoustic pulses accounting for fractional travel time.

J Acoust Soc Am 2018 Oct;144(4):2383

United States Army Cold Regions Research and Engineering Laboratory, 72 Lyme Road, Hanover, New Hampshire 03755, USA.

Predicting a full waveform of an acoustic broadband signal propagating over different impedance surfaces is a stringent test of both the method used in the modeling of propagation and the surface impedance models. It has been shown that predicted waveforms might be sensitive to the fractional travel time, when the propagation time of the pulse does not equal an integer number of computational time steps. A method overcoming this issue is developed and demonstrated for different propagation conditions: a pulse propagating over a snow layer, frozen ground, and their combinations along the propagating path with homogeneous and vertically stratified atmosphere for a range of 60 m. Read More

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October 2018
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