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    The cost of Lyme borreliosis.
    Eur J Public Health 2017 Apr 24. Epub 2017 Apr 24.
    National Institute of Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands.
    Background: Lyme borreliosis (LB) is the most frequently reported tick-borne infection in Europe and North America. The aim of this study was to estimate the cost-of-illness of LB in the Netherlands. We used available incidence estimates from 2010 for tick bite consultations and three symptomatic LB outcomes: erythema migrans (EM), disseminated LB and Lyme-related persisting symptoms. Read More

    Isolation of the Lyme Disease Spirochete Borrelia mayonii From Naturally Infected Rodents in Minnesota.
    J Med Entomol 2017 Apr 24. Epub 2017 Apr 24.
    Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Rd., Fort Collins, CO 80521
    Borrelia mayonii is a newly described member of the Borrelia burgdorferi sensu lato complex that is vectored by the black-legged tick (Ixodes scapularis Say) and a cause of Lyme disease in Minnesota and Wisconsin. Vertebrate reservoir hosts involved in the enzootic maintenance of B. mayonii have not yet been identified. Read More

    Pleomorphism and Viability of the Lyme Disease Pathogen Borrelia burgdorferi Exposed to Physiological Stress Conditions: A Correlative Cryo-Fluorescence and Cryo-Scanning Electron Microscopy Study.
    Front Microbiol 2017 11;8:596. Epub 2017 Apr 11.
    Biology Centre CAS, Institute of ParasitologyČeské Budějovice, Czechia.
    To understand the response of the Lyme disease spirochete Borrelia burgdorferi exposed to stress conditions and assess the viability of this spirochete, we used a correlative cryo-fluorescence and cryo-scanning microscopy approach. This approach enables simple exposition of bacteria to various experimental conditions that can be stopped at certain time intervals by cryo-immobilization, examination of cell viability without necessity to maintain suitable culture conditions during viability assays, and visualization of structures in their native state at high magnification. We focused on rare and transient events e. Read More

    Neuroretinitis as presenting and the only presentation of Lyme disease: Diagnosis and management.
    Indian J Ophthalmol 2017 Mar;65(3):250-252
    Department of Ophthalmology, VMMC and Safdarjung Hospital, New Delhi, India.
    We present a case of neuroretinitis as presenting and the only presentation of Lyme disease in a 25-year-old female who visited hilly areas in the Himalayas of North India. She presented with right eye sudden and painless blurring of vision. Her vision at presentation was 20/60. Read More

    Effects of conservation management of landscapes and vertebrate communities on Lyme borreliosis risk in the United Kingdom.
    Philos Trans R Soc Lond B Biol Sci 2017 Jun;372(1722)
    Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
    Landscape change and altered host abundance are major drivers of zoonotic pathogen emergence. Conservation and biodiversity management of landscapes and vertebrate communities can have secondary effects on vector-borne pathogen transmission that are important to assess. Here we review the potential implications of these activities on the risk of Lyme borreliosis in the United Kingdom. Read More

    Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control.
    Philos Trans R Soc Lond B Biol Sci 2017 Jun;372(1722)
    Department of Ecology, Evolution and Environmental Biology, Columbia University, New York, NY 10027, USA.
    Lyme disease is the most common tick-borne disease in temperate regions of North America, Europe and Asia, and the number of reported cases has increased in many regions as landscapes have been altered. Although there has been extensive work on the ecology and epidemiology of this disease in both Europe and North America, substantial uncertainty exists about fundamental aspects that determine spatial and temporal variation in both disease risk and human incidence, which hamper effective and efficient prevention and control. Here we describe areas of consensus that can be built on, identify areas of uncertainty and outline research needed to fill these gaps to facilitate predictive models of disease risk and the development of novel disease control strategies. Read More

    Detection of Anaplasma phagocytophilum, Babesia microti, Borrelia burgdorferi, Borrelia miyamotoi, and Powassan Virus in Ticks by a Multiplex Real-Time Reverse Transcription-PCR Assay.
    mSphere 2017 Mar-Apr;2(2). Epub 2017 Apr 19.
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
    Ixodes scapularis ticks are implicated in transmission of Anaplasma phagocytophilum, Borrelia burgdorferi, Borrelia miyamotoi, Babesia microti, and Powassan virus. We describe the establishment and implementation of the first multiplex real-time PCR assay with the capability to simultaneously detect and differentiate all five pathogens in a single reaction. The application of this assay for analysis of ticks at sites in New York and Connecticut revealed a high prevalence of B. Read More

    Application of Bayesian decision-making to laboratory testing for Lyme disease and comparison with testing for HIV.
    Int J Gen Med 2017 10;10:113-123. Epub 2017 Apr 10.
    Department of Medicine, Hammersmith Hospital, Imperial College London, London, UK.
    In this study, Bayes' theorem was used to determine the probability of a patient having Lyme disease (LD), given a positive test result obtained using commercial test kits in clinically diagnosed patients. In addition, an algorithm was developed to extend the theorem to the two-tier test methodology. Using a disease prevalence of 5%-75% in samples sent for testing by clinicians, evaluated with a C6 peptide enzyme-linked immunosorbent assay (ELISA), the probability of infection given a positive test ranged from 26. Read More

    Tick bite and Lyme disease-related emergency department encounters in New Hampshire, 2010-2014.
    Zoonoses Public Health 2017 Apr 22. Epub 2017 Apr 22.
    New Hampshire Department of Health and Human Services, Concord, NH, USA.
    Lyme disease (LD) is a common tick-borne disease in New Hampshire (NH). While LD is a reportable condition and cases are counted for public health surveillance, many more people receive care for tick bites or diagnoses of LD than are reflected in surveillance data. NH's emergency department (ED) data system was queried for tick bite and LD-related encounters. Read More

    A systematic review and meta-analysis for the adverse effects, immunogenicity and efficacy of Lyme disease vaccines: Guiding novel vaccine development.
    Can J Public Health 2017 Apr 20;108(1):e62-e70. Epub 2017 Apr 20.
    Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, Toronto, ON.
    Background: Lyme borreliosis (LB) is the most prevalent arthropod-borne infectious disease in North America. Currently, no vaccine is available to prevent LB in humans, although monovalent and multivalent vaccines have been developed in the past.

    Objective: The aim of the current study is to conduct a systematic review and meta-analysis to evaluate and compare the findings from these two classes of vaccines for their reactogenicity, immunogenicity and efficacy, in the hope this may assist in the development of future vaccines. Read More

    [Bilateral facial nerve palsy associated with Epstein-Barr virus infection in a 3-year-old boy].
    Arch Pediatr 2017 Apr 14. Epub 2017 Apr 14.
    Service de neuropédiatrie, CHRU Gui-de-Chauliac, 80, avenue Augustin-Fliche, 34000 Montpellier, France; PhyMedExpU1046 Inserm, UMR9214 CNRS, université de Montpellier, 34000 Montpellier, France.
    Bilateral facial nerve palsy is a rare and sometimes difficult diagnosis. We describe a case of bilateral simultaneous facial nerve palsy associated with Epstein-Barr virus (EBV) infection in a 3-year-old boy. Several symptoms led to the diagnosis of EBV infection: the clinical situation (fever, stomachache, and throat infection), white blood cell count (5300/mm(3) with 70% lymphocyte count), seroconversion with EBV-specific antibodies, lymphocytic meningitis, and a positive blood EBV polymerase chain reaction (9. Read More

    Liver microbiome of Peromyscus leucopus, a key reservoir host species for emerging infectious diseases in North America.
    Infect Genet Evol 2017 Apr 13;52:10-18. Epub 2017 Apr 13.
    Conservation Genetics Laboratory, University of Liège, Boulevard du Rectorat 26, 4000 Liège, Belgium; CIRAD, UR AGIRs, F-34398 Montpellier, France.
    Microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. Here we propose a first analysis of the liver microbiome using next generation sequencing as a tool to detect potentially pathogenic strains. We used Peromyscus leucopus, the main reservoir host species of Lyme disease in eastern North America, as a model and sequenced V5-V6 regions of the 16S gene from 18 populations in southern Quebec (Canada). Read More

    Successful treatment of fulminant Lyme myocarditis with mechanical circulatory support in a young male adult: a case report.
    Croat Med J 2017 Apr;58(2):185-193
    Željko Župan, Clinic of Anesthesiology and Intensive Care Medicine, University Hospital Center Rijeka, Tome Strižića 3, 51000 Rijeka, Croatia,
    We describe the case of fulminant myocarditis due to Lyme disease and use of mechanical circulatory support (MCS) for the treatment of the Lyme carditis associated with refractory cardiogenic shock. Fulminant Lyme myocarditis in young adult male patient led to a sudden onset of acute, severe biventricular heart failure with progressive cardiogenic shock, and multiorgan failure immediately after admission. Read More

    Bilateral Facial Diplegia: A Rare Presenting Symptom of Lyme.
    Case Rep Infect Dis 2017 16;2017:4521526. Epub 2017 Mar 16.
    Duke Lifepoint Conemaugh Memorial Medical Center, Department of Emergency Medicine, Johnstown, PA, USA.
    Lyme disease is a common disease that is faced by the physician but also acts a mimicker of many other disease processes. Facial palsies, especially bilateral, are a relatively rare presenting symptom of Lyme disease and may warrant further investigation. A thorough history and physical examination coupled with precision testing may aid the physician when faced with a patient with the diagnostic dilemma of facial diplegia. Read More

    Lyme Disease: A Case Report with Typical and Atypical Lesions.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):124-127
    Department of Anaesthesiology, Indira Gandhi Medical College, Himachal Pradesh, India.
    Lyme disease is a multisystem infectious disease caused by the spirochete "Borrelia burgdorferi," which is transmitted by "Ixodes" tick, with skin being the most common and earliest organ to be affected. Diagnosis of erythema chronicum migrans (ECM), which is the characteristic lesion of early disease, may help in early treatment and prevention of complications. Here, we are reporting a case of Lyme disease in a 10-year-old young boy from a non-endemic zone of Himachal Pradesh, who presented with typical as well as atypical ECM lesions. Read More

    Vertebrate Ticks Distribution and Their Role as Vectors in Relation to Road Edges and Underpasses.
    Vector Borne Zoonotic Dis 2017 Apr 12. Epub 2017 Apr 12.
    3 Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias , Universidad de La Laguna, La Laguna, Spain .
    Roads fragment vertebrate populations and affect the dynamics and dispersal patterns of vertebrate parasites. We evaluated how vertebrate ticks distribute near roads and road underpasses in human-caused road-fragmented landscapes in Seville, SW Spain. We sampled 49 stations with 93 individualized sampling points and assessed tick abundance. Read More

    Health Care Professionals' Evidence-Based Medicine Internet Searches Closely Mimic the Known Seasonal Variation of Lyme Borreliosis: A Register-Based Study.
    JMIR Public Health Surveill 2017 Apr 11;3(2):e19. Epub 2017 Apr 11.
    National Institute for Health and Welfare, Helsinki, Finland.
    Background: Both health care professionals and nonprofessionals seek medical information on the Internet. Using Web-based search engine searches to detect epidemic diseases has, however, been problematic. Physician's databases (PD) is a chargeable evidence-based medicine (EBM) portal on the Internet for health care professionals and is available throughout the entire health care system in Finland. Read More

    Evaluation of the SELECT Tick Control System (TCS), a Host-Targeted Bait Box, to Reduce Exposure to Ixodes scapularis (Acari: Ixodidae) in a Lyme Disease Endemic Area of New Jersey.
    J Med Entomol 2017 Mar 15. Epub 2017 Mar 15.
    Division of Vector-Borne Diseases, National Center for Enteric and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Rd., Fort Collins, CO 80521
    We describe a 2-yr trial to evaluate the ability of SELECT Tick Control System (TCS) host-targeted bait boxes to reduce numbers of host-seeking Ixodes scapularis nymphs in a residential neighborhood. After four successive 9-wk deployments, nymphal and larval I. scapularis infestation prevalence and intensity were significantly reduced on target small mammals. Read More

    A Risk Model for the Lyme Disease Vector Ixodes scapularis (Acari: Ixodidae) in the Prairie Provinces of Canada.
    J Med Entomol 2017 Feb 26. Epub 2017 Feb 26.
    Groupe de recherche en épidémiologie des zoonoses et santé publique, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada ( ; ; ).
    Lyme disease is emerging in Canada due to geographic range expansion of the tick vector Ixodes scapularis Say. Recent areas of emergence include parts of the southeastern Canadian Prairie region. We developed a map of potential risk areas for future I. Read More

    Acquisition of Borrelia burgdorferi Infection by Larval Ixodes scapularis (Acari: Ixodidae) Associated With Engorgement Measures.
    J Med Entomol 2017 Mar 18. Epub 2017 Mar 18.
    Department of Plant Sciences & Entomology, University of Rhode Island, Kingston, RI 02881 ( ; ; ; ).
    Measuring rates of acquisition of the Lyme disease pathogen, Borrelia burgdorferi sensu lato Johnson, Schmid, Hyde, Steigerwalt & Brenner, by the larval stage of Ixodes scapularis Say is a useful tool for xenodiagnoses of B. burgdorferi in vertebrate hosts. In the nymphal and adult stages of I. Read More

    Plasmodium spp. and Borrelia burgdorferi co-infection associated with antiphospholipid syndrome in a returned traveler: a case report.
    Clin Case Rep 2017 Apr 2;5(4):471-476. Epub 2017 Mar 2.
    Infectious Diseases DepartmentCentro Hospitalar São JoãoPortoPortugal; Infectious Diseases DepartmentFaculty of Medicine of University of PortoPortoPortugal; Institute of Health Innovation and Investigation (I3S)Nephrology and Infectious Diseases GroupNational Institute of Biomedical EngineeringPortoPortugal.
    The differential diagnosis of fever in a returned traveler is wide and challenging. We present a case of a patient working in Africa, who returned with fever, constitutional symptoms, headache, and blurred vision. An initial diagnosis of malaria was made, and additional workup revealed Borrelia burgdorferi co-infection and antiphospholipid syndrome. Read More

    Plasma fibronectin stabilizes Borrelia burgdorferi-endothelial interactions under vascular shear stress by a catch-bond mechanism.
    Proc Natl Acad Sci U S A 2017 Apr 10;114(17):E3490-E3498. Epub 2017 Apr 10.
    Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada M5S 3E2;
    Bacterial dissemination via the cardiovascular system is the most common cause of infection mortality. A key step in dissemination is bacterial interaction with endothelia lining blood vessels, which is physically challenging because of the shear stress generated by blood flow. Association of host cells such as leukocytes and platelets with endothelia under vascular shear stress requires mechanically specialized interaction mechanisms, including force-strengthened catch bonds. Read More

    Lyme disease and Bell's palsy: an epidemiological study of diagnosis and risk in England.
    Br J Gen Pract 2017 Apr 10. Epub 2017 Apr 10.
    Plastic Surgery Department, Queen Victoria Hospital, East Grinstead, West Sussex.
    Background: Lyme disease is caused by a tick-borne spirochaete of the Borrelia species. It is associated with facial palsy, is increasingly common in England, and may be misdiagnosed as Bell's palsy.Aim To produce an accurate map of Lyme disease diagnosis in England and to identify patients at risk of developing associated facial nerve palsy, to enable prevention, early diagnosis, and effective treatment. Read More

    Interferon-γ-induced protein 10 in Lyme disease.
    Clin Ter 2017 Mar-Apr;168(2):e146-e150
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
    Lyme disease is an infectious disease caused by bacteria of the Borrelia type, that affects about 300,000 people a year in the USA and 65,000 people a year in Europe. Borrelia infection, and Lyme disease, following occupational exposure has been frequently reported in USA, Europe and Asia. The manifestations of Lyme disease include erythema migrans (EM), arthritis, neuroborrelliosis (NB), and others. Read More

    Early Disseminated Lyme Disease Causing False Positive Serology for Primary Epstein-Barr Virus Infection - Report of 2 Cases.
    Clin Infect Dis 2017 Apr 4. Epub 2017 Apr 4.
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
    False positive serology for Lyme disease was reported in patients with acute infectious mononucleosis. Here we describe two patients with early-disseminated Lyme disease who were misdiagnosed with infectious mononucleosis based on false positive tests for primary Epstein-Barr virus infection. Read More

    Estimation of cognitive and affective disorders occurrence in patients with Lyme borreliosis.
    Ann Agric Environ Med 2017 Mar;24(1):33-38
    Department of Infectious Diseases, Specialistic Hospital No 1, Bytom, Poland.
    Introduction And Objective: Lyme borreliosis (LB) is a disease caused by the bacteria Borrelia burgdorferi. The most common symptoms are related to the skin, musculo-scelatal system, central and peripheral nervous system, rarely to the heart muscle and the eye, and may occur in the multistage course of the disease. LB may additionally be accompanied by psychopathological symptoms. Read More

    Was it authentic Lyme disease or some other disorder?
    Pathog Dis 2017 Apr;75(3)
    Department of Clinical Specialties, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY 11568, USA.
    We compared the evidence presented recently that challenges the long-standing belief that, in 1922, two French physicians reported the first case of neurological Lyme disease with a further analysis of the original findings that were translated and re-published in 1993. Alternative possibilities are offered that could explain these discrepant interpretations on what was considered to be a landmark clinical case of historical significance. Read More

    Standardized Symptom Measurement of Individuals with Early Lyme Disease Over Time.
    Arch Clin Neuropsychol 2017 Mar;32(2):129-141
    Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Objective: Understanding the Lyme disease (LD) literature is challenging given the lack of consistent methodology and standardized measurement of symptoms and the impact on functioning. This prospective study incorporates well-validated measures to capture the symptom picture of individuals with early LD from time of diagnosis through 6-months post-treatment.

    Method: One hundred seven patients with confirmed early LD and 26 healthy controls were evaluated using standardized instruments for pain, fatigue, depressive symptoms, functional impact, and cognitive functioning. Read More

    Tick Thioester-Containing Proteins and Phagocytosis Do Not Affect Transmission of Borrelia afzelii from the Competent Vector Ixodes ricinus.
    Front Cell Infect Microbiol 2017 16;7:73. Epub 2017 Mar 16.
    Biology Centre of the Czech Academy of Sciences, Institute of Parasitology Ceske Budejovice, Czechia.
    The present concept of the transmission of Lyme disease from Borrelia-infected Ixodes sp. ticks to the naïve host assumes that a low number of spirochetes that manage to penetrate the midgut epithelium migrate through the hemocoel to the salivary glands and subsequently infect the host with the aid of immunomodulatory compounds present in tick saliva. Therefore, humoral and/or cellular immune reactions within the tick hemocoel may play an important role in tick competence to act as a vector for borreliosis. Read More

    The influence of abiotic and biotic factors on the invasion of Ixodes scapularis in Ontario, Canada.
    Ticks Tick Borne Dis 2017 Mar 21. Epub 2017 Mar 21.
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada; Canadian Wildlife Health Cooperative, Ontario Veterinary College, University of Guelph,50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada. Electronic address:
    In northeastern North America, the blacklegged tick, Ixodes scapularis, is the vector of numerous tick-borne pathogens, including the agent of Lyme disease, Borrelia burgdorferi sensu stricto. Since 1990, there has been a rapid spread of I. scapularis northward into the province of Ontario, Canada. Read More

    [Studies on Lyme disease incidence rates in selected groups of forestry workers in West Pomerania, 2005-2014].
    Med Pr 2017 Mar 16;68(2):211-220. Epub 2017 Feb 16.
    Zachodniopomorski Uniwersytet Technologiczny w Szczecinie / West Pomeranian University of Technology Szczecin, Szczecin, Poland (Wydział Kształtowania Środowiska i Rolnictwa, Katedra Inżynierii Systemów Agrotechnicznych / Faculty of Environmental Management and Agriculture, Department for Engineering of Agrotechnical Systems).
    Background: The data collected by sanitary-epidemiological stations in 2005-2014 were analyzed to determine the incidence rates of borreliosis Lyme disease in the West Pomerania group of workers exposed to tick bites.

    Material And Methods: It was assumed that an adequate comparison of official epidemiological data with the data concerning the number of exposed people, is an indispensable condition for assessing properly the trend in Lyme disease incidence rates, concerning at the same time a real scale of occupational exposure. The study covered a selected group of forestry workers, i. Read More

    Evaluating the submission of digital images as a method of surveillance for Ixodes scapularis ticks.
    Parasitology 2017 Mar 27:1-7. Epub 2017 Mar 27.
    Public Health Risk Sciences Division,National Microbiology Laboratory,Public Health Agency of Canada,3200 Sicotte Street,PO 5000,Saint-Hyacinthe,Québec,CanadaJ2S 7C6.
    Widespread access to the internet is offering new possibilities for data collection in surveillance. We explore, in this study, the possibility of using an electronic tool to monitor occurrence of the tick vector of Lyme disease, Ixodes scapularis. The study aimed to compare the capacity for ticks to be identified in web-based submissions of digital images/photographs, to the traditional specimen-based identification method used by the provincial public health laboratory in Quebec, Canada. Read More

    Consumer segmentation and time interval between types of hospital admission: a clinical linkage database study.
    J Public Health (Oxf) 2017 Mar 14:1-9. Epub 2017 Mar 14.
    Health Services Research Unit, Guy Hilton Research Centre, Keele University, Stoke-on-Trent ST4 7QB, UK.
    Background: Healthcare policies target unplanned hospital admissions and 30-day re-admission as key measures of efficiency, but do not focus on factors that influence trajectories of different types of admissions in the same patient over time.

    Objectives: To investigate the influence of consumer segmentation and patient factors on the time intervals between different types of hospital admission.

    Research Design, Subjects And Measures: A cohort design was applied to an anonymised linkage database for adults aged 40 years and over (N = 58 857). Read More

    Evaluation of bioMérieux's dissociated VIDAS Lyme IgM II (LYM) and IgG II (LYG) as a first-tier diagnostic assay for Lyme disease.
    J Clin Microbiol 2017 Mar 22. Epub 2017 Mar 22.
    Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
    The recommended laboratory diagnostic approach for Lyme disease is a standard two-tiered testing (STTT) algorithm where the first-tier is typically an enzyme immunoassay (EIA) that if positive or equivocal is reflexed to Western immunoblotting as the second-tier. bioMérieux manufacturers one of the most commonly used first-tier EIAs in the U.S. Read More

    Evaluation of Modified 2-Tiered Serodiagnostic Testing Algorithms for Early Lyme Disease.
    Clin Infect Dis 2017 Apr;64(8):1074-1080
    Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.
    Background.: The conventional 2-tiered serologic testing protocol for Lyme disease (LD), an enzyme immunoassay (EIA) followed by immunoglobulin M and immunoglobulin G Western blots, performs well in late-stage LD but is insensitive in patients with erythema migrans (EM), the most common manifestation of the illness. Western blots are also complex, difficult to interpret, and relatively expensive. Read More

    Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi In Vitro.
    Antibiotics (Basel) 2017 Mar 22;6(1). Epub 2017 Mar 22.
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
    Lyme disease is a most common vector-borne disease in the US. Although the majority of Lyme patients can be cured with the standard two- to four-week antibiotic treatment, at least 10%-20% of patients continue to suffer from prolonged post-treatment Lyme disease syndrome (PTLDS). While the cause for this is unclear, one possibility is that persisting organisms are not killed by current Lyme antibiotics. Read More

    There Is a Method to the Madness: Strategies to Study Host Complement Evasion by Lyme Disease and Relapsing Fever Spirochetes.
    Front Microbiol 2017 2;8:328. Epub 2017 Mar 2.
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health Albany, NY, USA.
    Lyme disease and relapsing fever are caused by various Borrelia species. Lyme disease borreliae, the most common vector-borne pathogens in both the U.S. Read More

    Lyme Disease: Emergency Department Considerations.
    J Emerg Med 2017 Mar 10. Epub 2017 Mar 10.
    Emergency Center, University Medical Center, Lubbock, Texas.
    Background: Lyme disease (LD) is the most common vector-borne illness in North America. Reported cases of LD have increased from approximately 10,000 cases annually in 1991 to >25,000 cases in 2014. Greater recognition, enhanced surveillance, and public education have contributed to the increased prevalence, as have geographic expansion and the number of infected ticks. Read More

    Metabolomics of the tick-Borrelia interaction during the nymphal tick blood meal.
    Sci Rep 2017 Mar 13;7:44394. Epub 2017 Mar 13.
    Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA.
    The causal agents of Lyme disease in North America, Borrelia burgdorferi and Borrelia mayonii, are transmitted primarily by Ixodes scapularis ticks. Due to their limited metabolic capacity, spirochetes rely on the tick blood meal for nutrients and metabolic intermediates while residing in the tick vector, competing with the tick for nutrients in the blood meal. Metabolomics is an effective methodology to explore dynamics of spirochete survival and multiplication in tick vectors before transmission to a vertebrate host via tick saliva. Read More

    Diet-Induced Obesity Does Not Alter Tigecycline Treatment Efficacy in Murine Lyme Disease.
    Front Microbiol 2017 24;8:292. Epub 2017 Feb 24.
    Matrix Dynamics Group, Faculty of Dentistry, University of TorontoToronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of TorontoToronto, ON, Canada.
    Obese individuals more frequently suffer from infections, as a result of increased susceptibility to a number of bacterial pathogens. Furthermore, obesity can alter antibiotic treatment efficacy due to changes in drug pharmacokinetics which can result in under-dosing. However, studies on the treatment of bacterial infections in the context of obesity are scarce. Read More

    Searching for Lyme borreliosis in Australia: results of a canine sentinel study.
    Parasit Vectors 2017 Mar 13;10(1):114. Epub 2017 Mar 13.
    Department of Infectious Diseases and Zoonoses, Bacteriology and Mycology, Ludwig-Maximilians-University Munich, 80539, Munich, Germany.
    Background: Lyme borreliosis is a common tick-borne disease of the northern hemisphere that is caused by bacterial spirochaetes of the Borrelia burgdorferi (sensu lato) (Bbsl) complex. To date, there has been no convincing evidence for locally-acquired Lyme borreliosis on the Australian continent and there is currently a national debate concerning the nature and distributions of zoonotic tick-transmitted infectious disease in Australia. In studies conducted in Europe and the United States, dogs have been used as sentinels for tick-associated illness in people since they readily contact ticks that may harbour zoonotic pathogens. Read More

    Electrocardiographic progression of acute Lyme disease.
    Am J Emerg Med 2017 Mar 1. Epub 2017 Mar 1.
    Heart Rhythm Service, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada. Electronic address:
    Lyme carditis poses a challenge to physicians given dramatic clinical presentations like the one presented in this case. Quite frequently, these young patients are implanted with permanent pacemakers; given lack of knowledge on the transient nature of the cardiac conduction system inflammation. This is the first case in the literature that has captured the electrocardiographic evolution of Lyme carditis, day by day until complete resolution. Read More

    Borrelia burgdorferi Keeps Moving and Carries on: A Review of Borrelial Dissemination and Invasion.
    Front Immunol 2017 21;8:114. Epub 2017 Feb 21.
    Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Science Center , Bryan, TX , USA.
    Borrelia burgdorferi is the etiological agent of Lyme disease, a multisystemic, multistage, inflammatory infection resulting in patients experiencing cardiac, neurological, and arthritic complications when not treated with antibiotics shortly after exposure. The spirochetal bacterium transmits through the Ixodes vector colonizing the dermis of a mammalian host prior to hematogenous dissemination and invasion of distal tissues all the while combating the immune response as it traverses through its pathogenic lifecycle. The innate immune response controls the borrelial burden in the dermis, but is unable to clear the infection and thereby prevent progression of disease. Read More

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