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57,357 results match your criteria Luteinizing Hormone Deficiency


Electro-acupuncture attenuates the mice premature ovarian failure via mediating PI3K/AKT/mTOR pathway.

Life Sci 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Aims: Electro-acupuncture (EA) is frequently recommended as a complementary therapy for premature ovarian failure (POF) in the clinical. However, little information exists about its potential treatment mechanisms. The study was designed to observe the effect of EA to ovarian function and fertility in POF mice model, and investigated its potential mechanisms on PI3K/AKT/mTOR signaling pathway. Read More

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December 2018

Monosodium Glutamate in the Diet Does Not Raise Brain Glutamate Concentrations or Disrupt Brain Functions.

Authors:
John D Fernstrom

Ann Nutr Metab 2018 3;73 Suppl 5:43-52. Epub 2018 Dec 3.

The non-essential amino acid glutamate participates in numerous metabolic pathways in the body. It also performs important physiologic functions, which include a sensory role as one of the basic tastes (as monosodium glutamate [MSG]), and a role in neuronal function as the dominant excitatory neurotransmitter in the central nervous system. Its pleasant taste (as MSG) has led to its inclusion as a flavoring agent in foods for centuries. Read More

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December 2018

Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways.

Authors:
Ali A Shati

Syst Biol Reprod Med 2018 Dec 3:1-14. Epub 2018 Dec 3.

a Department of Biology , College of Science, King Khalid University , Abha , Saudi Arabia.

This study aimed to investigate the protective role of resveratrol (RES) against cisplatin (Cis)-induced testicular damage and reproductive dysfunction in rats and to examine the underlying mechanisms of protection including its effect on endoplasmic reticulum (ER) stress, P53, extracellular signal-regulated kinase (ERK)-1/2, stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and Protein kinase B (Akt) signaling. Eight-week-old Rats were divided into four groups (n = 12 each) of 1) control group: received normal saline (i.p. Read More

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December 2018

Hyperhydration Induced Decrease in Urinary Luteinizing Hormone Concentrations of Male Athletes may be Compensated by Specific Gravity Adjustment in Doping Control Analysis.

Int J Sport Nutr Exerc Metab 2018 Dec 3:1-28. Epub 2018 Dec 3.

1 Anti-Doping Lab Qatar, Sports City Road, Sports City, Doha, Qatar.

Low urinary luteinizing hormone (LH) values have been discussed as a marker to detect steroid abuse. However, suppressed LH concentrations related to highly diluted urine samples could be a misleading indication of anabolic steroid abuse. One aim of the present study was to examine the effect of hyperhydration on the interpretation of LH findings during doping control analysis and to investigate different possibilities to correct volume related changes in urinary LH concentrations. Read More

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December 2018

Increasing hypothalamic nucleobindin 2 levels and decreasing hypothalamic inflammation in obese male mice via diet and exercise alleviate obesity-associated hypogonadism.

Neuropeptides 2018 Nov 1. Epub 2018 Nov 1.

School of Kinesiology, Shanghai University of Sport, Shanghai 200438, PR China; School of Kinesiology, Shenyang Sport University, Shenyang, Liaoning 110102, PR China. Electronic address:

To explore the role of nesfatin-1 in regulating male reproductive function during energy balance variation, we employed an obese mouse model which was first induced by a high-fat diet (HFD) and followed by interventions of a normal diet (ND) and/or moderate exercise, and then serum reproductive hormones of male mice, hypothalamic nucleobindin 2 (NUCB2)/nesfatin-1, inflammatory factors, and gonadotropin-releasing hormone (GnRH) levels were tested. Our findings showed that both serum nesfatin-1, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels and hypothalamic NUCB2/nesfatin-1 and Gnrh mRNA levels were reduced, whereas, the mRNA and protein levels of hypothalamic tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, inhibitor kappa B kinase β (IKKβ), and nuclear factor (NF)-κB were increased in obese male mice. Diet, exercise, and diet combined with exercise interventions reversed the decreases in serum nesfatin-1, FSH, LH, and T levels; increased hypothalamic NUCB2/nesfatin-1 and Gnrh mRNA levels; and reduced hypothalamic TNF-α, IL-1β, IKKβ, and NF-κB levels. Read More

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November 2018

Ovarian Function In Adolescents Conceived By Assisted Reproductive Technologies.

J Pediatr Adolesc Gynecol 2018 Nov 28. Epub 2018 Nov 28.

Institute of Maternal and Child Research, School of Medicine, University of Chile.

Study Objective: To compare ovarian function between adolescents conceived using assisted reproductive technology (AcART) and adolescents who were conceived spontaneously (AcSP).

Design: Multicenter study of ovarian function in AcART due to male or tubal infertility.

Setting: University Hospital PARTICIPANTS: We evaluated 22 AcART and 53 AcSP at 1-2 years after menarche. Read More

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November 2018

Down-regulation of steroidogenesis-related genes and its accompanying fertility decline in streptozotocin-induced diabetic male rats: ameliorative effect of metformin.

Andrology 2018 Dec 4. Epub 2018 Dec 4.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Background: Metformin has long been used for glycemic control in diabetic state. Recently, other benefits of metformin beyond blood glucose regulation have emerged.

Objectives: To investigate the effect of metformin on the expression of testicular steroidogenesis-related genes, spermatogenesis, and fertility of male diabetic rats. Read More

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December 2018

Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress.

Proc Natl Acad Sci U S A 2018 Dec 4. Epub 2018 Dec 4.

Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany;

The adrenal gland is a master regulator of the human body during response to stress. This organ shows constant replacement of senescent cells by newly differentiated cells. A high degree of plasticity is critical to sustain homeostasis under different physiological demands. Read More

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December 2018
1 Read

Histone deacetylase inhibitors suppress transdifferentiation of gonadotrophs to prolactin cells and proliferation of prolactin cells induced by diethylstilbestrol in male mouse pituitary.

Histochem Cell Biol 2018 Dec 3. Epub 2018 Dec 3.

Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

Diethylstilbestrol (DES), an estrogen agonist, increases prolactin (PRL) cells through transdifferentiation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) cells to PRL cells as well as proliferation of PRL cells in adult male mouse pituitary. Since hyperacetylation of histone H3 is implicated in the regulation of activation of various genes, we examined the effect of DES on the state of histone H3 acetylation. DES significantly reduced the immunohistochemical signal for acetylated histone H3 at lysine 9 (H3K9ac) in PRL, LH and FSH cells, but not for H3K18ac or H3K23ac. Read More

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December 2018

An in vivo model to assess the thermoregulatory response of lactating Holsteins to an acute heat stress event occurring after a pharmacologically-induced LH surge.

J Therm Biol 2018 Dec 17;78:247-256. Epub 2018 Oct 17.

Department of Animal Science, The University of Tennessee Institute of Agriculture and AgResearch, Knoxville, TN, USA. Electronic address:

Hyperthermia occurring 10-12 h after LH surge reduces quality of maturing oocyte, thereby reducing fertility. Objective was to examine consequences of an acute heat stress and the influence of certain hormones on the thermoregulatory responses of lactating cows during this critical period. Between the months of February through May, cows were transported to a facility and maintained at a temperature-humidity index (THI) of 65. Read More

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December 2018

Evolution of the regulatory mechanism for hypothalamic-pituitary-gonadal axis in vertebrates - hypothesis from a comparative view.

Authors:
Shinji Kanda

Gen Comp Endocrinol 2018 Nov 27. Epub 2018 Nov 27.

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address:

Reproduction is regulated by the hypothalamic-pituitary-gonadal axis (HPG) in vertebrates. In addition to wealth of knowledge in mammals, recent studies in non-mammalian species, especially teleosts, have provided evidence that some of the components in the HPG axis are conserved in bony vertebrates. On the other hand, from the comparisons of the recent accumulating knowledge between mammals and teleosts, unique characteristics of the regulatory system in each group have been unveiled. Read More

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November 2018

Associations between biochemical components of human semen with seminal conditions.

Syst Biol Reprod Med 2018 Nov 30:1-9. Epub 2018 Nov 30.

a Department of Molecular and Developmental Medicine , University of Siena , Siena , Italy.

The aim of the study was to assess whether abnormal levels of seminal biochemical components could be associated with semen alterations and infertility. In this study, 92 human ejaculates from selected men were analyzed. Albumin, estradiol, ferritin, total proteins (TP), folic acid (FA), vitamin B12, alkaline phosphatase (ALP), creatine kinase (CK), gamma-glutamyl transpeptidase (GGT), lactate dehydrogenase were evaluated. Read More

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November 2018

Ovulation: Parallels with Inflammatory Processes.

Endocr Rev 2018 Nov 28. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, University of Kentucky, Lexington, KY.

The midcycle surge of luteinizing hormone (LH) sets in motion interconnected networks of signaling cascades to bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators of these LH-induced signaling cascades are associated with inflammation, leading to the postulate that ovulation is similar to an inflammatory response. First responders to the LH surge are granulosa and theca cells, which produce steroids, prostaglandins, chemokines, and cytokines, which are also mediators of inflammatory processes. Read More

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November 2018

Interaction of positive coactivator 4 with histone 3.3 protein is essential for transcriptional activation of the luteinizing hormone receptor gene.

Biochim Biophys Acta Gene Regul Mech 2018 Oct 13;1861(10):971-981. Epub 2018 Sep 13.

Section on Molecular Endocrinology, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

The luteinizing hormone receptor (LHR) is essential for sexual development and reproduction in mammals. We have established that Sp1 has a central role in derepression of LHR gene transcription induced by Trichostatin A (TSA) in MCF7 cells. Moreover, the co-activator PC4 which associates directly with Sp1 at the LHR promoter is essential for TSA-mediated LHR transcription. Read More

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October 2018

Perfluorododecanoic acid blocks rat Leydig cell development during prepuberty.

Chem Res Toxicol 2018 Nov 29. Epub 2018 Nov 29.

Perfluorododecanoic acid (PFDoA) has been used as a surfactant and may have reproductive toxicity. However, whether PFDoA influences Leydig cell development during prepuberty remains unknown. In the present study, 21-day-old male Sprague Dawley rats were gavaged 0, 5 or 10 mg/kg PFDoA from postnatal day 21 to 35. Read More

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November 2018
2 Reads

Combined therapy using LHRH-PE40 and anti-CD40 dendritic cells substantially eliminate tumor cells.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Tianjin Huanhu Hospital, Tianjin, China.

LHRH-PE40 was used to promote the proliferation of bone marrow derived cell (BMDC) and improve the antigen-presenting ability of BMDC as well as the immune function via the CD40 signal pathway. LHRH-PE40 was also implicated in cancer treatment, targeting a variety of cancer cells that express luteinizing hormone-releasing hormone receptor (LHRHR). In the present study, the mechanism and efficacy of LHRH-PE40 were addressed in the following three aspects. Read More

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November 2018

No Relationship of Anti-Androgens to Alzheimer's Disease or Cognitive Disorder in the MedWatch Database.

J Alzheimers Dis Rep 2018 Jun 30;2(1):123-127. Epub 2018 Jun 30.

Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Two large studies suggest that risk is not increased. But other studies have found increased risk of Alzheimer's disease and impaired cognition.

Objective: To determine whether androgen deprivation therapy increases the risk of impaired cognition or Alzheimer's disease in men with prostate cancer. Read More

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June 2018
1 Read

Bi-allelic recessive loss-of-function mutations in FIGLA cause premature ovarian insufficiency with short stature.

Clin Genet 2018 Nov 25. Epub 2018 Nov 25.

IVF Center, Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Premature ovarian insufficiency (POI) is a group of heterogeneous disorders characterized by decreased ovarian reserve and increased follicle stimulating hormone (FSH) levels. It is rarely associated with short stature. FIGLA mutations with POI are identified with regards to heterozygosity; till date, only one affected family has been identified with homozygous mutations in FIGLA but without functional evaluation. Read More

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November 2018
1 Read

Can peri-ovulatory putrescine supplementation improve egg quality in older infertile women?

J Assist Reprod Genet 2018 Nov 22. Epub 2018 Nov 22.

Ottawa Hospital Research Institute, The Ottawa Hospital-General Campus, 501 Smyth Road, Box 511, Ottawa, K1H 8L6, Canada.

The aging-related decline in fertility is an increasingly pressing medical and economic issue in modern society where women are delaying family building. Increasingly sophisticated, costly, and often increasingly invasive, assisted reproductive clinical protocols and laboratory technologies (ART) have helped many older women achieve their reproductive goals. Current ART procedures have not been able to address the fundamental problem of oocyte aging, the increased rate of egg aneuploidy, and the decline of developmental potential of the eggs. Read More

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November 2018
9 Reads

Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis.

Phytomedicine 2018 Nov 29;50:247-256. Epub 2017 Nov 29.

Independent Researcher, Bidar 585401, Karnataka, India.

Background: Withania somnifera Dunal, commonly known as Indian ginseng, has been in use since ancient times as anti-stress agent, aphrodisiac, for impotence and infertility treatment.

Purpose: To evaluate the efficacy and safety of W. somnifera treatment in infertile men. Read More

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November 2018
4 Reads

Occupational manganese exposure, reproductive hormones, and semen quality in male workers: A cross-sectional study.

Toxicol Ind Health 2018 Nov 22:748233718810109. Epub 2018 Nov 22.

1 Department of Environmental Health, School of Public Health, China Medical University, Shenyang, China.

It has been found that exposure to manganese (Mn) could induce reproductive dysfunction, but its occupational risk in male workers is unclear. This study aims to assess the association of occupational Mn exposure with reproductive hormones and semen quality in a cross-sectional study. Urinary Mn, semen quality, and reproductive hormones were explored in 84 male workers occupationally exposed to Mn and 92 referents. Read More

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November 2018
1 Read

Immunization against Kisspeptin-54 perturb hypothalamic-pituitary-testicular signaling pathway in ram lambs.

Theriogenology 2018 Nov 6;125:193-202. Epub 2018 Nov 6.

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, People's Republic of China.

Kisspeptin, a peptide product of KISS1 gene, recently identified as essential upstream gatekeeper in hypothalamic-pituitary-gonadal (HPG) axis. This study was designed to investigate the effect of immunization against kisspeptin-54 on hypothalamic-pituitary-testicular signaling pathway. A total of ten intact 56-days-old ram lambs were used and randomized into the treatment and control groups, which were, respectively immunized by kisspeptin-54 based vaccine and the empty plasmid via intramuscular route. Read More

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November 2018
8 Reads

Total flavonoids extracted from  in the treatment of polycystic ovary syndrome through IL-6 mediated JAK2/STAT3 signaling pathway.

Biosci Rep 2018 Nov 21. Epub 2018 Nov 21.

Colleage of Public Health, Guilin Medical University, Guilin, China

Large doses of flavonoids could cure many diseases with no serious side effects. However, the role of flavonoids in the treatment of polycystic ovary syndrome (PCOS) has not been reported. Therefore, total flavonoids extracted from were selected to explore its therapeutic efficiency in PCOS. Read More

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November 2018
3 Reads

Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial.

Eur J Nutr 2018 Nov 20. Epub 2018 Nov 20.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.

Purpose: It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline.

Methods: The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. Read More

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November 2018
1 Read

Precocious or early puberty in patients with combined pituitary hormone deficiency due to POU1F1 gene mutation: case report and review of possible mechanisms.

Hormones (Athens) 2018 Nov 20. Epub 2018 Nov 20.

Istanbul Faculty of Medicine, Department of Pediatrics, Pediatric Endocrinology Unit, Istanbul University, Çapa 34093, Istanbul, Turkey.

Central precocious puberty (CPP) or early puberty (EP) is a rare entity in combined pituitary hormone deficiency (CPHD), the latter caused by mutations in pituitary transcription factor genes. The early onset of puberty in two patients with CPHD with POU1F1 gene mutation was evaluated. A 3-month-old boy was diagnosed with central hypothyroidism, and L-thyroxine was commenced. Read More

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November 2018
3 Reads

Adrenal crisis presented as acute onset of hypercalcemia and hyponatremia triggered by acute pyelonephritis in a patient with partial hypopituitarism and pre-dialysis chronic kidney disease.

CEN Case Rep 2018 Nov 19. Epub 2018 Nov 19.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

A 57-year-old woman with pre-dialysis chronic kidney disease (CKD) was hospitalized because of fever and fatigue. On admission, increased inflammatory response and pyuria with bacteriuria were observed. Pyelonephritis was successfully treated with antibiotics, whereas her fatigue continued and she developed progressive hypercalcemia and hyponatremia; serum sodium level, 116 mEq/L and corrected serum calcium level, 13. Read More

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November 2018
5 Reads

Improvement of Pituitary Function after Carotid Revascularization in Patients with Abnormal Cerebral Perfusion - A Pilot Study.

Acta Cardiol Sin 2018 Nov;34(6):472-480

Division of Cardiology.

Background: Brain ischemia may affect hypothalamic-pituitary axis function, which may influence the outcomes of patients with internal carotid artery (ICA) stenosis/occlusion. The objective of this study was to determine the influence of successful carotid revascularization on pituitary function in patients with severe ICA stenosis/occlusion.

Methods: This study was conducted from April 2009 to December 2014. Read More

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November 2018

Sport, doping and female fertility.

Reprod Biol Endocrinol 2018 Nov 19;16(1):108. Epub 2018 Nov 19.

Department of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", via S. Sofia 78, 95123, Catania, Italy.

This article is a review that addresses the following topics, divided by paragraphs. The first paragraph investigates the effects of physical activity on ovarian function, analyzing in particular the changes concerning the serum concentrations of follicle-stimulating hormone, luteinizing hormone, prolactin, growth hormone, thyroid hormones, leptin, ghrelin, neuropeptide Y. The second paragraph analyzes the effects of doping on the hypothalamic-pituitary-ovarian axis. Read More

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November 2018
2.410 Impact Factor

Short-term effects of surgical weight loss after sleeve gastrectomy on sex steroids plasma levels and PSA concentration in men with severe obesity.

Aging Male 2018 Nov 17:1-5. Epub 2018 Nov 17.

a Clinica Medica 3, Department of Medicine - DIMED, School of Medicine , University of Padova , Via Giustiniani 2 , Padova , Italy.

Male obesity is known to be associated with hypogonadism, which can be reverted after surgical weight reduction. However, the evidence about how rapidly this effect rises after surgery and what consequences each procedure have on prostate function and prostatic-specific antigen (PSA) concentration is scarce. So, we evaluated total testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone and PSA plasma levels in a group of 29 Caucasian obese men (BMI - 43. Read More

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November 2018
2 Reads

Novel Compound Heterozygous Variants in the Gene in a Genetically Male Patient with Female External Genitalia.

J Clin Res Pediatr Endocrinol 2018 Nov 16. Epub 2018 Nov 16.

Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China.

Objectives: The gene encodes a G-protein coupled receptor that plays a pivotal role in sexual differentiation in males, ovarian development in females, and in fertility via its interaction with luteinizing hormone (LH) and chorionic gonadotropin (CG). Inactive variants of the gene cause Leydig cell hypoplasia (LCH), which is a rare disease and one of the causes of disorder of sexual differentiation (DSD) in males. The aim of this work is to study the clinical and molecular characteristics of a 2-year-9-month old patient with type 1 LCH. Read More

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November 2018
4 Reads

Study of Clinical Sample Detection for LH With Lateral Flow Immunochromatographic Strip Using Support Vector Regression.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:4285-4288

Membrane-based lateral flow immuno-chromatographic strip (LFICS) is widely used in the measurement of Luteinizing hormone (LH) because of its advantages such as easy to handle, low costs, room temperature storage and transport, no need for long storage or transportation of samples and no requirement for skilled technicians. However, LFICS can only provide qualitative or semi-quantitative results without quantitative information, which greatly limited its application. In this paper, we developed a novel quantitative detection method for LFICS using support vector regression (SVR). Read More

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GnRH agonist deslorelin implant alters the progesterone release pattern during early pregnancy in gilts.

Reprod Domest Anim 2018 Nov 15. Epub 2018 Nov 15.

Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Finland.

The aim of this study was to investigate the relationship of progesterone (P) and luteinizing hormone (LH) during recognition and establishment of pregnancy in the gilt. Therefore effects of eliminating episodic LH pulses on P patterns were determined during early pregnancy. To this end, a slow-release GnRH implant deslorelin was used for GnRH downregulation. Read More

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November 2018

GnRH antagonist versus follicular-phase single-dose GnRH agonist protocol in patients of normal ovarian responses during controlled ovarian stimulation.

Gynecol Endocrinol 2018 Nov 15:1-5. Epub 2018 Nov 15.

a Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , People's Republic of China.

Objective: This study aims to explore the differences of the ovarian stimulation (OS) characteristics, laboratory, and clinical outcomes between follicular-phase single-dose gonadotropin-releasing hormone (GnRH) agonist protocol and GnRH antagonist protocol during controlled ovarian hyperstimulation (COH).

Methods: About 1883 consecutive IVF/ICSI fresh cycles of normal ovarian responders were retrospectively analyzed, with 1229 in the single-dose GnRH agonist protocol group and 654 in the GnRH antagonist protocol group at Reproductive Medical Center of Tongji Hospital from 1 January 2014 to 31 December 2017.

Results: The follicular-phase single-dose GnRH agonist group showed significantly more oocytes obtained, higher implantation rate and pregnancy rate, as well as lower luteinizing hormone (LH) level and estradiol (E2)/oocyte ratio on the day of human chorionic gonadotropin (hCG) administration. Read More

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November 2018

Modulatory effects of methanolic fruit fraction of Pedalium murex on sulphasalazine-induced male reproductive disruption.

Andrologia 2018 Nov 14:e13190. Epub 2018 Nov 14.

Reproductive Physiology and Endocrinology Section, Centre of Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, India.

Pedalium murex is widely practiced in Ayurveda for the treatment of sexual disorders, but their detailed scientific evaluations are still unexplored. Therefore, the present study was conducted to assess the effect of methanolic fruit fraction of P. murex (MfPm) against sulphasalazine (SSZ) induced male reproductive disruption. Read More

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November 2018
6 Reads

Phoenixin: Expression at different ovarian development stages and effects on genes ralated to reproduction in spotted scat, Scatophagus argus.

Comp Biochem Physiol B Biochem Mol Biol 2018 Nov 10;228:17-25. Epub 2018 Nov 10.

Fisheries College, Guangdong Ocean University, Zhanjiang 524088, China; Guangdong Research Center on Reproductive Control and Breeding Technology of Indigenous Valuable Fish Species, Zhanjiang 524088, China. Electronic address:

Phoenixin (Pnx), a recently discovered neuropeptide, has been implicated in reproduction. Pnx mainly exists in two active isoforms, phoenixin-14 (Pnx-14) and phoenixin-20 (Pnx-20). However, little is known about the functions of Pnx in teleosts. Read More

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November 2018
1 Read

The association of miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T polymorphisms with a risk of primary ovarian insufficiency in Korean women.

Menopause 2018 Nov 12. Epub 2018 Nov 12.

Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.

Objective: The purpose of this study was to investigate the association of microRNA polymorphisms (miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T) with primary ovarian insufficiency (POI) in Korean women.

Methods: We conducted a case-control study of Korean women: 142 participants with POI and 266 controls with at least 1 live birth and no history of pregnancy loss.

Results: The haplotype-based multifactor dimensionality reduction analysis revealed that the T-C-T-G (miR-25/-32/-125/-222), T-A-C-G (miR-25/-32/-125/-222), C-T-G (miR-32/-125/-222), A-C-G (miR-32/-125/-222), T-G (miR-122/-222), C-T (miR-32/-125), and C-C (miR-25/-32) inferred haplotypes were significantly less frequent in POI (P < 0. Read More

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November 2018
2 Reads

Sex- and sub region-dependent modulation of arcuate kisspeptin neurons by vasopressin and vasoactive intestinal peptide.

J Neuroendocrinol 2018 Nov 13:e12660. Epub 2018 Nov 13.

Centre for Neuroendocrinology and Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, 9054, New Zealand.

A population of kisspeptin neurons located in the hypothalamic arcuate nucleus (ARN) very likely represent the gonadotrophin-releasing hormone pulse generator responsible for driving pulsatile luteinizing hormone secretion in mammals. As such, it has become important to understand the neural inputs that modulate the activity of ARN kisspeptin (ARN ) neurons. Using a transgenic GCaMP6 mouse model allowing the intracellular calcium levels (i[Ca ]) of individual ARN neurons to be assessed simultaneously, we examined whether the circadian neuropeptides vasoactive intestinal peptide (VIP) and arginine vasopressin (AVP) modulated the activity of ARN neurons directly. Read More

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November 2018

Exploring Dynamics and Noise in Gonadotropin-Releasing Hormone (GnRH) Signaling.

Methods Mol Biol 2018 ;1819:405-429

Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Bristol, UK.

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes. These are G-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. FSH and LH control steroidogenesis and gametogenesis in the gonads so GnRH mediates control of reproduction by the central nervous system. Read More

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January 2018
1 Read

Bitter taste receptor ligand improves metabolic and reproductive functions in a murine model of PCOS.

Endocrinology 2018 Nov 9. Epub 2018 Nov 9.

Johns Hopkins University School of Medicine, Department of Pediatrics, Division of Endocrinology, Baltimore, MD.

Polycystic ovary syndrome (PCOS) results from functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Cultured theca cells from polycystic ovaries of women with the most common form of PCOS overexpress most androgen producing enzymes, particularly CYP450c17. This study used a murine model of PCOS induced by chronic feeding with high fat content diet that exhibits the reproductive, hyperandrogenic, and metabolic constellation of symptoms of PCOS seen in women. Read More

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November 2018
6 Reads

Changes in GABAergic Transmission to and Intrinsic Excitability of Gonadotropin-Releasing Hormone (GnRH) Neurons during the Estrous Cycle in Mice.

eNeuro 2018 Sep-Oct;5(5). Epub 2018 Nov 8.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.

Gonadotropin-releasing hormone (GnRH) neurons form the final common central output pathway controlling fertility and are regulated by steroid feedback. In females, estradiol feedback action varies between negative and positive; negative feedback typically regulates episodic GnRH release whereas positive feedback initiates a surge of GnRH, and subsequently luteinizing hormone (LH) release ultimately triggering ovulation. During the estrous cycle, changes between estradiol negative and positive feedback occur with cycle stage and time of day, with positive feedback in the late afternoon of proestrus in nocturnal species. Read More

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November 2018
6 Reads

Less known aspects of central hypothyroidism: Part 1 - Acquired etiologies.

J Clin Transl Endocrinol 2018 Dec 26;14:25-33. Epub 2018 Sep 26.

Department of Medical Endocrinology and Metabolism, Rigshospitalet, National University Hospital, Copenhagen University, Copenhagen, Denmark.

Central hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH concentrations can be normal or even above the upper normal reference limit. Indeed, certain patients are at risk of developing CH, such as those with a pituitary adenoma or hypophysitis, those who have been treated for a childhood malignancy, have suffered a head trauma, sub-arachnoid hemorrhage or meningitis, and those who are on drugs capable to reduce TSH secretion. Read More

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December 2018
4 Reads

Risk assessment of endocrine disrupting phthalates and hormonal alterations in children and adolescents.

J Toxicol Environ Health A 2018 12;81(21):1150-1164. Epub 2018 Nov 12.

a Division of Toxicology , College of Pharmacy, Sungkyunkwan University , Suwon , Gyeonggi-do , South Korea.

Risk assessment and hormone evaluation were carried out for di(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP), endocrine disrupting chemicals (EDCs), in 302 Korean children (n = 223) and adolescents (n = 79) (< age 19). Urinary and serum concentrations of DEHP, MEHP (mono(2-ethylhexyl) phthalate), DBP, MBP (monobutyl phthalate), and PA (phthalic acid, a common final metabolite of phthalates) were detected in children and adolescents. Daily exposure levels were estimated to be 16. Read More

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November 2018

Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice.

Life Sci 2018 Nov 7. Epub 2018 Nov 7.

Guangdong Engineering & Technology Research Center for Disease-Model Animals, Program in Cardiovascular Disease and Metabolism, the Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; Department of Biochemistry, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; Laboratary Animal Center, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. Electronic address:

Aims: This study aims to investigate the pathophysiological role and mechanism of pigment epithelium-derived factor (PEDF) deletion in ovarian damage.

Methods: Female PEDF-knockout mice and their wild-type littermates were used in this study. Relevant tests were performed at 8-10 weeks or 32 weeks of age. Read More

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November 2018
6 Reads

Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes.

Int J Gynaecol Obstet 2018 Nov 8. Epub 2018 Nov 8.

Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Objective: To explore assisted reproductive outcomes among women with different polycystic ovary syndrome (PCOS) phenotypes.

Methods: A retrospective cohort study included women with PCOS who were treated at Yazd Research and Clinical Center for Infertility, Yazd, Iran, using the GnRH antagonist protocol between April 1, 2015, and August 31, 2017. Clinical pregnancy was the primary outcome, and chemical pregnancy, implantation rate, fertilization rate, and spontaneous abortion rate, were the secondary outcomes that were evaluated among four defined phenotypes of women with PCOS. Read More

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November 2018
2 Reads

Efficacy and Safety of gonadotropin-releasing hormone (GnRH) Agonists Triptorelin Acetate and Cetrorelix Acetate in Assisted Reproduction.

Med Sci Monit 2018 Nov 8;24:7996-8000. Epub 2018 Nov 8.

Center for Reproductive Medicine, Shandong University, Jinan, Shandong, China (mainland).

BACKGROUND The aim of this study was to compare the efficacy and safety of 2 GnRH agonists - triptorelin acetate and cetrorelix acetate - in assisted reproduction. MATERIAL AND METHODS A total of 182 females who received in vitro fertilization and embryo transfer (IVF+ET) from March 2014 to July 2014 were involved, and their clinical data were retrospectively analyzed. Among them, 91 patients received treatment with short-acting triptorelin (group A) and another 91 patients were treated with cetrorelix acetate (group B). Read More

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November 2018

Can Panax Ginseng protect against fertility disorders in hypothyroid female albino rats?

Cell Mol Biol (Noisy-le-grand) 2018 Oct 30;64(13):97-102. Epub 2018 Oct 30.

Faculty of Medicine, Taibah university, KSA.

Hypothyroidism is an endocrine disorder due to decreased thyroid hormone production. This endocrine disorder significantly affects the menstrual cycle and fertility. The aim of this present study was to assess the efficacy of Panax ginseng, one of traditional Chinese medicine, in ameliorating the gonadal hormonal dysfunction and lowering oxidative stress accompanied with hypothyroidism in adult female albino rats. Read More

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October 2018
9 Reads

GnRH antagonist treatment of malignant adrenocortical tumors.

Endocr Relat Cancer 2019 Jan;26(1):103-117

Institute of Biomedicine, University of Turku, Turku, Finland.

Aberrantly expressed G protein-coupled receptors in tumors are considered as potential therapeutic targets. We analyzed the expressions of receptors of gonadotropin-releasing hormone (GNRHR), luteinizing hormone/chorionic gonadotropin (LHCGR) and follicle-stimulating hormone (FSHR) in human adrenocortical carcinomas and assessed their response to GnRH antagonist therapy. We further studied the effects of the GnRH antagonist cetrorelix acetate (CTX) on cultured adrenocortical tumor (ACT) cells (mouse Cα1 and Y-1, and human H295R), and in vivo in transgenic mice (SV40 T-antigen expression under inhibin α promoter) bearing Lhcgr and Gnrhr in ACT. Read More

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January 2019
4 Reads

Fertility hormones and vitamin E in active and passive adult male smokers in Calabar, Nigeria.

PLoS One 2018 6;13(11):e0206504. Epub 2018 Nov 6.

Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.

Smoking is an extremely lethal act and is associated with many illnesses. Lately, major concerns that passive smokers face the same health risks as (if not higher than) active smokers have been raised. Some studies have shown that active smoking is associated with low serum levels of vitamins and testosterone. Read More

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November 2018
137 Reads
3.230 Impact Factor

Evaluation of a Novel General Pituitary Hormone Score to Evaluate the Function of the Residual Anterior Pituitary (Adenohypophysis) in Patients Following Surgery for Pituitary Adenoma.

Med Sci Monit 2018 Nov 6;24:7944-7951. Epub 2018 Nov 6.

Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University, Fuzhou, Fujian, China (mainland).

BACKGROUND The aim was to develop and assess a general pituitary hormone score to evaluate the function of the anterior pituitary (adenohypophysis) in patients following resection of pituitary adenomas. MATERIAL AND METHODS Sixty-six patients with pituitary null cell macroadenoma (1-3 cm diameter) (N=38) and pituitary null cell giant adenoma (≥3 cm diameter) (N=28) had preoperative and postoperative data including magnetic resonance imaging (MRI) and measurement of six pituitary hormones levels, adrenocorticotropic hormone (ACTH), growth hormone (GH), thyroid-stimulating hormone (TSH), prolactin (PRL), follicle-stimulating hormone (FSH), and luteinizing hormone (LH). The postoperative general pituitary hormone score, for 57 patients who underwent subtotal resection (>60%) and nine patients who underwent partial resection (≤60%), was 1-5 for each hormone level (score range, 6-30). Read More

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November 2018
2 Reads

Hypoxic stress: A risk factor for post-concussive hypopituitarism?

Med Hypotheses 2018 Dec 6;121:31-34. Epub 2018 Sep 6.

Vienna Chiropractic Associates, P.C. (Private Practice of Chiropractic), 243 Church Street NW, #300-B, Vienna, VA 22180, USA. Electronic address:

Hypopituitarism diagnosed months or years following concussive injury can cause a variety of endocrine disturbances including insufficient secretion of human growth, luteinizing, follicle stimulating, thyroid stimulating, adrenocorticotrophic, and antidiuretic hormones. Recent evidence suggests that autoimmune reactions against pituitary and/or hypothalamic tissue constitute an etiologic factor for this hypopituitarism. One important trigger for autoimmunity is hypoxic stress. Read More

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December 2018
2 Reads