Am J Physiol Endocrinol Metab 2021 03 11;320(3):E496-E511. Epub 2021 Jan 11.
Department of Cell Biology, Physiology and Immunology, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain.
Tachykinin (TAC) signaling is an important element in the central control of reproduction. TAC family is mainly composed of substance P (SP), neurokinin A (NKA), and NKB, which bind preferentially to NK1, NK2, and NK3 receptors, respectively. While most studies have focused on the reproductive functions of NKB/NK3R, and to a lesser extent SP/NK1R, the relevance of NK2R, encoded by , remains poorly characterized. Read More