2,051 results match your criteria Luteinizing Hormone Deficiency


Growth Pattern in Chinese Children With 5α-Reductase Type 2 Deficiency: A Retrospective Multicenter Study.

Front Pharmacol 2019 15;10:173. Epub 2019 Mar 15.

Center of Endocrinology, Genetics and Metabolism, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Background: 5α-reductase type 2 deficiency (5αRD) is an autosomal recessive hereditary disease of the group of 46, XY disorders of sex development (DSD).

Objective: To study the growth pattern in Chinese pediatric patients with 5αRD.

Subjects: Data were obtained from 141 patients with 5αRD (age: 0-16 years old) who visited eight pediatric endocrine centers from January 2010 to December 2017. Read More

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http://dx.doi.org/10.3389/fphar.2019.00173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429988PMC
March 2019
1 Read

Neonatal estrogen causes irreversible male infertility via specific suppressive action on hypothalamic Kiss1 neurons.

Endocrinology 2019 Mar 28. Epub 2019 Mar 28.

Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.

Aberrant exposure to estrogen-like compounds during the critical developmental period may cause improper hypothalamic programming, thus resulting in reproductive dysfunction in adulthood in male mammals. Kisspeptin-neurokinin B (NKB)-dynorphin A (Dyn) (KNDy) neurons in the arcuate nucleus (ARC) have been suggested to govern tonic gonadotropin-releasing hormone (GnRH)/gonadotropin release to control reproduction in male mammals. Here we report that chronic exposure to supra-physiological levels of estrogen during the neonatal period caused an irreversible suppression of KNDy genes in the ARC, resulting in reproductive dysfunction in male rats. Read More

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http://dx.doi.org/10.1210/en.2018-00732DOI Listing
March 2019
1 Read

Cryptozoospermia after treatment with clomiphene citrate following long-term use of intramuscular testosterone undecanoate depot injection (Nebido®).

Horm Mol Biol Clin Investig 2019 Mar 14. Epub 2019 Mar 14.

Department of Physiology, Immunology and Pathophysiology, University of Rijeka Faculty of Medicine, B. Branchetta 20, 51000 Rijeka, Croatia, Phone +385-51-651 238, Mobile Phone: +385-91-755-06-47, Fax +385-51-675 699.

Objective To illustrate the importance of treatment duration with intramuscular testosterone undecanoate (Nebido®) for the final spermatogenesis recovery after treatment cessation. Also, to show a subsequent poor efficacy of the selective estrogen receptor modulator (SERM) clomiphene citrate (CC) in treating steroid-induced azoospermia following Nebido® cessation and describe that initial oligozoospermia, existing before starting Nebido®, largely contributes to that treatment outcome. Methodology Setting: Department of Human Reproduction and Department of Endocrinology, Clinical Hospital Center Rijeka, Rijeka, and Department of Endocrinology, Clinical Hospital Center Sestre milosrdnice, Zagreb, Croatia. Read More

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http://dx.doi.org/10.1515/hmbci-2018-0078DOI Listing
March 2019
3 Reads

Clinical, biochemical, and molecular overview of transaldolase deficiency and evaluation of the endocrine function: Update of 34 patients.

J Inherit Metab Dis 2019 Jan;42(1):147-158

Metabolic Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.

Background: Transaldolase deficiency (TALDO-D) is a rare autosomal recessive inborn error of the pentose phosphate pathway. Since its first description in 2001, several case reports have been published, but there has been no comprehensive overview of phenotype, genotype, and phenotype-genotype correlation.

Methods: We performed a retrospective questionnaire and literature study of clinical, biochemical, and molecular data of 34 patients from 25 families with proven TALDO-D. Read More

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http://dx.doi.org/10.1002/jimd.12036DOI Listing
January 2019
4 Reads

Prepubertal IGF-1 and possible relation with physical features of growth and Type 1 Diabetes Mellitus.

Curr Diabetes Rev 2019 Feb 6. Epub 2019 Feb 6.

Internal Medicine Department, Endocrinology unit,Ain Shams University hospitals,Cairo. Egypt.

Introduction: T1DM is considered the most common chronic metabolic autoimmune disorder in childhood and adolescence as well as in early adulthood. It appears frequently during 12-13 years of age with distinctive features like immune-mediated chronic damage of pancreatic β-cells, leading eventually to partial, or mostly, absolute insulin deficiency. Insulin-like growth factor 1 (IGF-1) is a polypeptide consisting of 70 amino acids with insulin-like chemical structure. Read More

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http://dx.doi.org/10.2174/1573399815666190206161230DOI Listing
February 2019
4 Reads

Two novel heterozygous mutations in the CYP17A1 gene in a Chinese patient with 17α-hydroxylase 17,20-lyase deficiency.

Discov Med 2018 12;26(145):243-249

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.

Congenital adrenal hyperplasia (CAH) resulting from 17α-hydroxylase/17,20-lyase deficiency (17-OHD) is an uncommon autosomal recessive disease. 17-OHD is caused by mutations in the cytochrome P450c17 gene (CYP17A1), and characterized by hypertension, hypokalemia, female sexual infantilism, or male pseudohermaphroditism. Here we report a case of a 19-year-old Chinese girl (46,XX) with 17-OHD, and analyze her clinical and molecular genetic characteristics. Read More

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December 2018
3 Reads

Association of low testosterone with changes in non-cardiovascular biomarkers in adult men.

Int J Impot Res 2019 Jan 22. Epub 2019 Jan 22.

UMC Utrecht, Laboratory of Clinical Chemistry and Hematology, G03.550, Heidelberglaan 100, 3584CX, Utrecht, Netherlands.

Testosterone has effects on many organs and systems. The purpose of this study was to test the hypothesis that low testosterone is associated with changes in various non-cardiovascular biomarkers in men older than 40 who were tested for possible hypogonadism. We extracted data from 9939 outpatient men who were over 40 years old (median age 56) and who also had concurrent laboratory measurements of total testosterone and one or more biomarkers of interest: estradiol, uric acid, prostate-specific antigen (PSA), sex-hormone binding globulin (SHBG), luteinizing hormone, creatinine, bone alkaline phosphatase (BAP), creatine kinase, hemoglobin A1c, and 25-hydroxy-vitamin D, and body mass index (BMI). Read More

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http://dx.doi.org/10.1038/s41443-019-0112-4DOI Listing
January 2019
2 Reads

Mu Opioid Receptor Regulation of Gonadotropin-Releasing Hormone-Luteinizing Hormone Axis during Short-Term Food Deprivation: Role of Alpha1-Adrenoreceptor Signaling.

Neuro Endocrinol Lett 2018 Dec;39(5):363-370

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.

Objectives: Brain bio-energetic stability is required for optimal gonadal steroid positive-feedback activation of the gonadotropin-releasing hormone-I (GnRH-I)-pituitary luteinizing hormone (LH) neuroendocrine axis. Caudal hindbrain metabolic-sensory noradrenergic neurons counter energy deficiency by curtailing the mid-cycle LH surge. Central mu opioid receptors (mu-R) impose inhibitory effects of diverse physiological stimuli, including stress, on LH. Read More

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December 2018
6 Reads

Leptin mediates the effects of melatonin on female reproduction in mammals.

J Pineal Res 2019 Apr 26;66(3):e12559. Epub 2019 Feb 26.

State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.

Melatonin is a natural molecule produced in the pineal gland and other tissues. It participates in numerous biological activities including the regulation of reproduction. However, the mechanism by which melatonin affects mammalian female reproductive performance is not fully investigated. Read More

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http://dx.doi.org/10.1111/jpi.12559DOI Listing
April 2019
11 Reads

Clinical, Histochemical, and Molecular Study of Three Turkish Siblings Diagnosed with H Syndrome, and Literature Review.

Horm Res Paediatr 2019 Jan 9:1-10. Epub 2019 Jan 9.

Department of Paediatric Allergy and Immunology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey.

Background: The term "H syndrome" was coined to denote the major clinical findings, which include hyperpigmentation, hypertrichosis, hearing loss, hepatosplenomegaly, hyperglycaemia, hypogonadism, hallux flexion contractures, and short height.

Objective: To report the clinical, endocrinological, histochemical, and genetic findings of three siblings.

Methods: Skin and liver biopsies were taken to investigate the histochemical characteristics of hyperpigmented hypertrichotic skin lesions and massive hepatomegaly. Read More

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https://www.karger.com/Article/FullText/495190
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http://dx.doi.org/10.1159/000495190DOI Listing
January 2019
10 Reads

Role of Follicle-Stimulating Hormone in Spermatogenesis.

Front Endocrinol (Lausanne) 2018 14;9:763. Epub 2018 Dec 14.

Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom.

Spermatogenesis is a concerted sequence of events during maturation of spermatogonia into spermatozoa. The process involves differential gene-expression and cell-cell interplay regulated by the key endocrine stimuli, i.e. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00763
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http://dx.doi.org/10.3389/fendo.2018.00763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302021PMC
December 2018
21 Reads

A new class of pentapeptide KISS1 receptor agonists with hypothalamic-pituitary-gonadal axis activation.

Bioorg Med Chem Lett 2019 Feb 10;29(4):654-658. Epub 2018 Dec 10.

Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd., Fujisawa 251-8555, Japan.

The kisspeptin (Kp, Kp-54, metastin)/KISS1R system plays crucial roles in regulating the secretion of gonadotropin-releasing hormone. Continuous administration of nonapeptide Kp analogs caused plasma testosterone depletion, whereas bolus administration caused strong plasma testosterone elevation in male rats. To develop a new class of small peptide drugs, we focused on stepwise N-terminal truncation of Kp analogs and discovered potent pentapeptide analogs. Read More

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http://dx.doi.org/10.1016/j.bmcl.2018.12.016DOI Listing
February 2019
3 Reads

NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning.

J Gerontol A Biol Sci Med Sci 2018 Dec 17. Epub 2018 Dec 17.

Department of Pathology, Nagasaki University School of Medicine, Graduate School of Biomedical Sciences, Nagasaki, Japan.

The orexigenic hormone neuropeptide Y (NPY) plays a pivotal role in the peripheral regulation of fat metabolism. However, the mechanisms underlying the effects of sex on NPY function have not been extensively analyzed. In this study, we examined the effects of NPY deficiency on fat metabolism in male and female mice. Read More

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https://academic.oup.com/biomedgerontology/advance-article/d
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http://dx.doi.org/10.1093/gerona/gly282DOI Listing
December 2018
14 Reads

Vitamin D deficiency in infertile patients.

Arch Esp Urol 2018 Dec;71(10):850-855

Department of Urology. Ataturk University Medical Faculty. Erzurum. Turkey.

Objectives: According to the WorldHealth Organization (WHO) definition, infertility is "thefailure of a sexually active, non-contracepting couple toachieve pregnancy in one year" and is a complicateddisorder with its medical, psychosocial and economicaspects. There is some proof that vitamin D deficiencyhas important effects on the male reproductive system.There are numerous animal trials and a limited numberof human trials investigating this topic. Read More

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December 2018
7 Reads

Can peri-ovulatory putrescine supplementation improve egg quality in older infertile women?

J Assist Reprod Genet 2019 Mar 22;36(3):395-402. Epub 2018 Nov 22.

Ottawa Hospital Research Institute, The Ottawa Hospital-General Campus, 501 Smyth Road, Box 511, Ottawa, K1H 8L6, Canada.

The aging-related decline in fertility is an increasingly pressing medical and economic issue in modern society where women are delaying family building. Increasingly sophisticated, costly, and often increasingly invasive, assisted reproductive clinical protocols and laboratory technologies (ART) have helped many older women achieve their reproductive goals. Current ART procedures have not been able to address the fundamental problem of oocyte aging, the increased rate of egg aneuploidy, and the decline of developmental potential of the eggs. Read More

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http://dx.doi.org/10.1007/s10815-018-1327-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439130PMC
March 2019
41 Reads

Precocious or early puberty in patients with combined pituitary hormone deficiency due to POU1F1 gene mutation: case report and review of possible mechanisms.

Hormones (Athens) 2018 Dec 20;17(4):581-588. Epub 2018 Nov 20.

Istanbul Faculty of Medicine, Department of Pediatrics, Pediatric Endocrinology Unit, Istanbul University, Çapa 34093, Istanbul, Turkey.

Central precocious puberty (CPP) or early puberty (EP) is a rare entity in combined pituitary hormone deficiency (CPHD), the latter caused by mutations in pituitary transcription factor genes. The early onset of puberty in two patients with CPHD with POU1F1 gene mutation was evaluated. A 3-month-old boy was diagnosed with central hypothyroidism, and L-thyroxine was commenced. Read More

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http://dx.doi.org/10.1007/s42000-018-0079-4DOI Listing
December 2018
16 Reads

Less known aspects of central hypothyroidism: Part 1 - Acquired etiologies.

J Clin Transl Endocrinol 2018 Dec 26;14:25-33. Epub 2018 Sep 26.

Department of Medical Endocrinology and Metabolism, Rigshospitalet, National University Hospital, Copenhagen University, Copenhagen, Denmark.

Central hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH concentrations can be normal or even above the upper normal reference limit. Indeed, certain patients are at risk of developing CH, such as those with a pituitary adenoma or hypophysitis, those who have been treated for a childhood malignancy, have suffered a head trauma, sub-arachnoid hemorrhage or meningitis, and those who are on drugs capable to reduce TSH secretion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146237183006
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http://dx.doi.org/10.1016/j.jcte.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205405PMC
December 2018
16 Reads

Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice.

Life Sci 2019 Jan 7;216:129-139. Epub 2018 Nov 7.

Guangdong Engineering & Technology Research Center for Disease-Model Animals, Program in Cardiovascular Disease and Metabolism, the Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; Department of Biochemistry, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; Laboratary Animal Center, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. Electronic address:

Aims: This study aims to investigate the pathophysiological role and mechanism of pigment epithelium-derived factor (PEDF) deletion in ovarian damage.

Methods: Female PEDF-knockout mice and their wild-type littermates were used in this study. Relevant tests were performed at 8-10 weeks or 32 weeks of age. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183072
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http://dx.doi.org/10.1016/j.lfs.2018.11.015DOI Listing
January 2019
18 Reads

Metabolic Profile of Patients with Premature Ovarian Insufficiency.

J Clin Med 2018 Oct 21;7(10). Epub 2018 Oct 21.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Polna 33, Poznan 60-535, Poland.

Premature ovarian insufficiency (POI) is hypogonadism associated with amenorrhea, increased levels of gonadotropins, and hypoestrogenism. Deficiency of estrogens may contribute to higher risk of cardiovascular diseases and death. POI patients present several risk factors for the development of cardiovascular diseases (CVD): endothelial dysfunction, abnormal lipid profile, insulin resistance, and insulin action disturbances. Read More

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http://www.mdpi.com/2077-0383/7/10/374
Publisher Site
http://dx.doi.org/10.3390/jcm7100374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210159PMC
October 2018
53 Reads

Female Reproductive, Adrenal, and Metabolic Changes during an Antarctic Traverse.

Med Sci Sports Exerc 2019 Mar;51(3):556-567

Research & Clinical Innovation, Royal Centre for Defence Medicine, Lichfield, UNITED KINGDOM.

Purpose: To explore the effects of the first all-female transantarctic expedition on hormonal axes pertinent to reproductive and metabolic function.

Methods: Six females (age, 28-36 yr; body mass index, 24.2 ± 0. Read More

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http://Insights.ovid.com/crossref?an=00005768-900000000-9678
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http://dx.doi.org/10.1249/MSS.0000000000001803DOI Listing
March 2019
20 Reads

PITUITARY EVALUATION IN PATIENTS WITH LOW PROSTATE-SPECIFIC ANTIGEN.

Endocr Pract 2018 Dec 5;24(12):1030-1037. Epub 2018 Oct 5.

Objective: To evaluate pituitary function in men with a low screening prostate-specific antigen (PSA) of ≤0.1 ng/mL and test the hypothesis that low PSA is associated with hypogonadism alone or other hormone deficiency.

Methods: This was a case-control study evaluating the rates of hypogonadism and low insulin-like growth factor (IGF)-1 in a cohort of men with low or normal screening PSA level. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0204
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http://dx.doi.org/10.4158/EP-2018-0204DOI Listing
December 2018
17 Reads
2.811 Impact Factor

Subcutaneous Leydig Stem Cell Autograft: A Promising Strategy to Increase Serum Testosterone.

Stem Cells Transl Med 2019 Jan 2;8(1):58-65. Epub 2018 Oct 2.

Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Exogenous testosterone therapy can be used to treat testosterone deficiency; however, it has several adverse effects including infertility due to negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis. Leydig stem cell (LSC) transplantation could provide a new strategy for treating testosterone deficiency, but clinical translatability of injecting stem cells inside the testis is not feasible. Here, we explore the feasibility of subcutaneously autografting LSCs in combination with Sertoli and myoid cells to increase testosterone. Read More

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http://doi.wiley.com/10.1002/sctm.18-0069
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http://dx.doi.org/10.1002/sctm.18-0069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312442PMC
January 2019
18 Reads
3.600 Impact Factor

Natesto Effects on Reproductive Hormones and Semen Parameters: Results from an Ongoing Single-center, Investigator-initiated Phase IV Clinical Trial.

Eur Urol Focus 2018 04 1;4(3):333-335. Epub 2018 Sep 1.

Department of Urology, University of Miami, Miami, FL, USA.

Promising initial data from our perspective clinical trial demonstrates that Natesto can not only increase serum testosterone but also maintain follicle-stimulating hormone, luteinizing hormone, and importantly, semen parameters. Read More

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http://dx.doi.org/10.1016/j.euf.2018.08.009DOI Listing
April 2018
1 Read

Dietary vitamin D supplementation protects laying hens against lipopolysaccharide-induced immunological stress.

Nutr Metab (Lond) 2018 10;15:58. Epub 2018 Aug 10.

State Key Lab of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193 People's Republic of China.

Background: The effects of vitamin D on the immune function of laying hens are not well understood. This study investigated the effects of vitamin D (VD) on laying performance and immunological functions in laying hens under lipopolysaccharide (LPS) challenge.

Methods: In experiment one, 360 Jinghong-1 strain layers (32 weeks) were randomly divided into four groups with six replicates per group and 15 hens per replicate. Read More

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https://nutritionandmetabolism.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12986-018-0293-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086064PMC
August 2018
14 Reads

Do 5α-Reductase Inhibitors Raise Circulating Serum Testosterone Levels? A Comprehensive Review and Meta-Analysis to Explaining Paradoxical Results.

Sex Med Rev 2019 01 8;7(1):95-114. Epub 2018 Aug 8.

Men's Health Boston, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Introduction: Many studies have reported that 5α-reductase inhibitors (finasteride and dutasteride) raise serum testosterone (T) levels, yet there is lack of consistency among studies on this point.

Aim: To review and meta-analyze available studies reporting changes in serum T concentrations in men treated with 5α-reductase inhibitors (5α-RIs).

Methods: A Medline search using PubMed and EMBASE was performed including the following key words: "finasteride," "dutasteride," "testosterone and 5α-reductases. Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.06.002DOI Listing
January 2019
8 Reads

Management Strategies in Opioid Abuse and Sexual Dysfunction: A Review of Opioid-Induced Androgen Deficiency.

Sex Med Rev 2018 Oct 26;6(4):618-623. Epub 2018 Jul 26.

Division of Urology, Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA; Department of Urology, Hackensack University Medical Center, Hackensack, NJ, USA. Electronic address:

Introduction: Over the last several decades, the opioid epidemic has become a national crisis, largely spurred by the spike in the use of prescription painkillers. With the epidemic came a concomitant rise in the incidence of opioid-induced androgen deficiency (OPIAD). Although OPIAD can significantly impact male sexual function and quality of life, it is an overlooked and poorly understood clinical entity that requires more attention from healthcare providers. Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.04.003DOI Listing
October 2018
25 Reads

Leptin restores markers of female fertility in lipodystrophy.

Biochim Biophys Acta Mol Basis Dis 2018 Oct 23;1864(10):3292-3297. Epub 2018 Jul 23.

Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany. Electronic address:

Objectives: Female reproductive dysfunction occurs in patients with pathological loss of adipose tissue, i.e. lipodystrophy (LD). Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.07.015DOI Listing
October 2018
5 Reads

MECHANISMS IN ENDOCRINOLOGY: Hormonal regulation of spermatogenesis: mutant mice challenging old paradigms.

Authors:
Ilpo Huhtaniemi

Eur J Endocrinol 2018 Sep 29;179(3):R143-R150. Epub 2018 Jun 29.

Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK.

The two pituitary gonadotrophins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and in particular LH-stimulated high intratesticular testosterone (ITT) concentration, are considered crucial for spermatogenesis. We have revisited these concepts in genetically modified mice, one being the ()-knockout mouse (LuRKO), the other a transgenic mouse expressing in Sertoli cells a highly constitutively active mutated (Fshr-CAM). It was found that full spermatogenesis was induced by exogenous testosterone treatment in LuRKO mice at doses that restored ITT concentration to a level corresponding to the normal circulating testosterone level in WT mice, ≈5 nmol/L, which is 1. Read More

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http://dx.doi.org/10.1530/EJE-18-0396DOI Listing
September 2018
5 Reads

A Dose-Escalating Study With the Fetal Estrogen Estetrol in Healthy Men.

J Clin Endocrinol Metab 2018 Sep;103(9):3239-3249

Andros Men's Health Institutes, CV Arnhem, Netherlands.

Context: Luteinizing hormone-releasing hormone (LHRH) agonists have replaced estrogens for endocrine treatment of advanced prostate cancer (PC) because of cardiovascular side effects. The fetal estrogen estetrol (E4) may be safer for PC treatment and is expected to decrease testosterone (T) and prevent estrogen deficiency.

Objective: To investigate the safety and T-suppressive effect of E4 in healthy men. Read More

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http://dx.doi.org/10.1210/jc.2018-00147DOI Listing
September 2018
14 Reads

Towards the Clinical Evaluation of the Luteal Phase in Fertile Women: A Preliminary Study of Normative Urinary Hormone Profiles.

Front Public Health 2018 31;6:147. Epub 2018 May 31.

Facultad de Medicina, Universidad de los Andes, Santiago, Chile.

To describe and evaluate urinary hormone profiles in the luteal phase. Twenty-five healthy fertile women, with regular ovulatory pattern cycles as assessed by temperature and cervical mucus, at a university based center. Daily urinary hormonal assessment of luteinizing hormone, estrone glucuronide, and pregnanediol glucuronide. Read More

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http://dx.doi.org/10.3389/fpubh.2018.00147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991009PMC
May 2018
3 Reads

Long-term treatment outcomes of intermittent androgen deprivation therapy for relapsed prostate cancer after radical prostatectomy.

PLoS One 2018 24;13(5):e0197252. Epub 2018 May 24.

Department of Urology, Obihiro-Kosei General Hospital, Obihiro, Hokkaido, Japan.

Purpose: Intermittent androgen deprivation therapy is an effective treatment for metastatic prostate cancer. However, no study to date has evaluated the long-term outcomes of this treatment among patients with prostate cancer after radical prostatectomy. We retrospectively examined the treatment outcomes of patients with prostate-specific antigen recurrence who underwent radical prostatectomy at our department. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197252PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967753PMC
December 2018
5 Reads

Prevalence of Indicators of Low Energy Availability in Elite Female Sprinters.

Int J Sport Nutr Exerc Metab 2018 Sep 17;28(5):490-496. Epub 2018 Aug 17.

2 University of Guelph.

Low energy availability (LEA), and subsequent relative energy deficiency in sport, has been observed in endurance, aesthetic, and team sport athletes, with limited data on prevalence in athletes in short-burst activities such as sprinting. We examined prevalence of signs and symptoms of LEA in elite female sprinters at the start of the training season (PRE), and at the end of a 5-month indoor training period (POST). Four of 13 female sprinters (31%) presented at PRE testing with at least one primary (amenorrhea, low bone mineral density, low follicle-stimulating hormone, luteinizing hormone, or estradiol, resting metabolic rate ≤29 kcal/kg fat-free mass, Low Energy Availability in Females Questionnaire score ≥8) and one secondary indicator of LEA (fasting blood glucose <4 mmol/L, free triiodothyronine <3. Read More

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https://journals.humankinetics.com/doi/10.1123/ijsnem.2017-0
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http://dx.doi.org/10.1123/ijsnem.2017-0397DOI Listing
September 2018
12 Reads

[Value of the serum free testosterone level in detecting erectile dysfunction].

Zhonghua Nan Ke Xue 2017 Sep;23(9):808-812

Department of Andrology, Guangzhou First People's Hospital Affiliated to Guangzhou Medical University, Guangzhou, Guangdong 510180, China.

Objective: To investigate the values of serum calculated free testosterone (cFT), testosterone secretion index (TSI), and free testosterone index (FTI) in the diagnosis of ED with androgen deficiency by observing their changes in the patient.

Methods: We conducted this study among 185 men complaining of ED and 35 20-40 years old healthy males presenting at the clinic for premarital medical checkup. We asked them about their medical history, to fill in the International Index of Erectile Function (IIEF-5) Questionnaire, and to complete the nocturnal penile tumescence (NPT) test. Read More

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September 2017
13 Reads

[Low serum testosterone level does not predict bone metastasis of prostate cancer].

Zhonghua Nan Ke Xue 2017 Mar;23(3):212-216

Department of Urology, The Affiliated Hospital of Jiujiang College, Jiujiang, Jiangxi 332000, China.

Objective: To evaluate the role of the serum testosterone level as an independent predictor of bone metastasis of prostate cancer.

Methods: This study included 165 male patients with prostate cancer confirmed by biopsy. The patients were aged 58-78 (66. Read More

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March 2017
8 Reads

In Vitro Fertilization Using Luteinizing Hormone-Releasing Hormone Injections Resulted in Healthy Triplets without Increased Attack Rates in a Hereditary Angioedema Case.

Case Reports Immunol 2018 13;2018:2706751. Epub 2018 Feb 13.

Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, İzmir, Turkey.

Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The management of pregnant patients with C1-INH-HAE is a challenge for the physician. Intravenous plasma-derived nanofiltered C1-INH (pdC1INH) is the only recommended option throughout pregnancy, postpartum, and breastfeeding period. Read More

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http://dx.doi.org/10.1155/2018/2706751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831601PMC
February 2018
4 Reads

Short-term Assessment of HSCT Effects on the Hypothalamus-Pituitary Axis in Pediatric Thalassemic Patients.

Arch Iran Med 2018 02 1;21(2):56-60. Epub 2018 Feb 1.

Hematology-Oncology and Stem Cell Transplantation Research Center of Tehran University of Medical Sciences, Tehran, Iran.

Background: Beta thalassemia major (BTM) and its treatment by hematopoietic stem cell transplantation (HSCT) may have deleterious effects on the endocrine systems. We assessed endocrine complications of HSCT in pediatric patients for 3 months.

Methods: In 20 (6 female) pediatric major thalassemic patients (mean age of 10. Read More

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February 2018
16 Reads

GONADOPENIA AND AGING IN MEN.

Endocr Pract 2018 Apr;24(4):375-385

Objective: The decrease in testosterone levels that occurs with aging has become an important clinical issue both due to the growth of the geriatric population and patient interest in testosterone therapy. The decision to assess for testosterone deficiency and the ability to determine whether the benefits exceed the risks require a comprehensive evaluation of the aging patient. This article is part of a series of papers focused on the endocrinology of aging. Read More

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http://journals.aace.com/doi/10.4158/EP-2017-0131
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http://dx.doi.org/10.4158/EP-2017-0131DOI Listing
April 2018
9 Reads

Undetectable high-density lipoprotein cholesterol in acute malaria.

J Clin Lipidol 2018 May - Jun;12(3):822-825. Epub 2018 Mar 9.

Guy's, St Thomas' and Lewisham and Greenwich Trust, St. Thomas' Hospital, London, United Kingdom.

We report the case of a 39-year-old West African man in whom high-density lipoprotein cholesterol (HDL-C) was identified as undetectable at <0.08 mmol/L. Total cholesterol in the same sample was 2. Read More

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http://dx.doi.org/10.1016/j.jacl.2018.02.019DOI Listing
March 2018
16 Reads

S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism.

J Sex Med 2018 May 30;15(5):654-661. Epub 2018 Mar 30.

Department of Urology, University of Miami, Miami, FL, USA. Electronic address:

Background: Excess reactive oxygen species and reactive nitrogen species are implicated in male infertility and impaired spermatogenesis.

Aim: To investigate the effect of excess reactive nitrogen species and nitrosative stress on testicular function and the hypothalamic-pituitary-gonadal axis using the S-nitrosoglutathione reductase-null (Gsnor) mouse model.

Methods: Testis size, pup number, and epididymal sperm concentration and motility of Gsnor mice were compared with those of age-matched wild-type (WT) mice. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.03.002DOI Listing
May 2018
9 Reads
3.151 Impact Factor

Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis.

J Clin Invest 2018 May 26;128(5):1787-1792. Epub 2018 Mar 26.

Institute of Reproductive and Developmental Biology (IRDB), Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.

Spermatogenesis is regulated by the 2 pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This process is considered impossible without the absolute requirement of LH-stimulated testicular testosterone (T) production. The role of FSH remains unclear because men and mice with inactivating FSH receptor (FSHR) mutations are fertile. Read More

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https://www.jci.org/articles/view/96794
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http://dx.doi.org/10.1172/JCI96794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919831PMC
May 2018
9 Reads

Evaluation and Treatment of Male Hypogonadism.

JAMA 2018 Apr;319(13):1375-1376

University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2018.3182DOI Listing
April 2018
5 Reads

Hormonal, metabolic and skeletal phenotype of Schaaf-Yang syndrome: a comparison to Prader-Willi syndrome.

J Med Genet 2018 May 1;55(5):307-315. Epub 2018 Mar 1.

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA.

Background: Nonsense and frameshift mutations in the maternally imprinted, paternally expressed gene located in the Prader-Willi critical region 15q11-15q13, have been reported to cause Schaaf-Yang syndrome (SYS), a genetic disorder that manifests as developmental delay/intellectual disability, hypotonia, feeding difficulties and autism spectrum disorder. Prader-Willi syndrome (PWS) is a genetic disorder characterised by severe infantile hypotonia, hypogonadotrophic hypogonadism, early childhood onset obesity/hyperphagia, developmental delay/intellectual disability and short stature. Scoliosis and growth hormone insufficiency are also prevalent in PWS. Read More

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http://dx.doi.org/10.1136/jmedgenet-2017-105024DOI Listing
May 2018
11 Reads

The SET protein promotes androgen production in testicular Leydig cells.

Andrology 2018 05 26;6(3):478-487. Epub 2018 Feb 26.

State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Approximately 40% of middle-aged men exhibit symptoms of late-onset hypogonadism (LOH). However, the mechanism of androgen deficiency is still currently unclear. As shown in our previous studies, the SET protein is expressed in testicular Leydig cells and ovarian granule cells. Read More

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http://dx.doi.org/10.1111/andr.12476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001814PMC
May 2018
4 Reads

Homozygous nonsense mutation Trp28X in the LHB gene causes male hypogonadism.

J Assist Reprod Genet 2018 May 23;35(5):913-919. Epub 2018 Feb 23.

State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Purpose: The purpose of this study was to investigate a novel mutation in the luteinizing hormone beta-subunit (LHB) gene in one male patient with hypogonadism due to selective luteinizing hormone (LH) deficiency.

Methods: Sanger sequencing of one 28-year-old man born to consanguineous parents was performed. Treatment with human chorionic gonadotropin (hCG) (2000 IU, twice a week) was initiated for 3 months, followed by 5000 IU weekly to date. Read More

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http://dx.doi.org/10.1007/s10815-018-1133-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984881PMC
May 2018
10 Reads

FSH may be a useful tool to allow early diagnosis of Turner syndrome.

BMC Endocr Disord 2018 Feb 7;18(1). Epub 2018 Feb 7.

Department of Medical Genetics, FCM, Unicamp, Rua Tessalia Vieira de Camargo, 126, Campinas, SP, 13083-887, Brazil.

Background: Ultrasensitive assays to measure pre-pubertal gonadotropins levels could help identify patients with Turner syndrome (TS) in mid-childhood, but studies in this field are scarce. The aim of this study was to analyze gonadotropins levels in girls with TS throughout childhood.

Methods: Retrospective longitudinal study conducted with 15 girls with TS diagnosed with < 5 years whose FSH and LH measures were available since then. Read More

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http://dx.doi.org/10.1186/s12902-018-0236-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803864PMC
February 2018
14 Reads

Congenital Hypopituitarism.

Authors:
John S Parks

Clin Perinatol 2018 03;45(1):75-91

Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

Mutations of growth hormone genes and pituitary transcription factors account for a small proportion of cases of severe congenital hypopituitarism. Most cases show characteristic MRI findings of pituitary stalk interruption syndrome. Clinical suspicion should prompt assessment of cortisol, free T4, thyroid-stimulating hormone, and growth hormone levels together with MRI of the hypothalamic and pituitary regions. Read More

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http://dx.doi.org/10.1016/j.clp.2017.11.001DOI Listing
March 2018
4 Reads

Lower rate of early pregnancy loss in patients experiencing early-onset low LH in GnRH antagonist cycles supplemented with menotropin.

J Formos Med Assoc 2019 Jan 7;118(1 Pt 1):92-98. Epub 2018 May 7.

Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background/purpose: The role of LH during controlled ovarian stimulation (COS) in the general population remains contentious. There is no consensus on the indications for LH supplementation during COS. The purpose of this study is to determine whether menotropin supplement is associated with decreases in early pregnancy loss rates in patients exhibiting low endogenous LH during COS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646173072
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http://dx.doi.org/10.1016/j.jfma.2018.01.012DOI Listing
January 2019
14 Reads

Isolated follicle stimulated hormone deficiency in male: case report.

BMC Res Notes 2018 Jan 15;11(1):24. Epub 2018 Jan 15.

Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Recent rapid advances in assisted reproductive health technologies enables couples with subfertility to conceive through various intervention. Majority of treatment modalities target the female partner. However it is important to identify and treat male factor subfertility right at the outset. Read More

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http://dx.doi.org/10.1186/s13104-017-3109-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769506PMC
January 2018
8 Reads

The assessment of testosterone and radioisotopic index of bone metabolism and bone mineral density in men with testosterone deficiency after one year of testosterone therapy.

Nucl Med Rev Cent East Eur 2018 10;21(1):14-19. Epub 2018 Jan 10.

Department of Radiological and Isotopic Diagnosis and Therapy, Medical University of Lodz, 113 Zeromskiego Street, 90-549 Lodz, Poland.

Background: Testosterone deficiency in men is characterized by typical symptoms of hypogonadism and negative influence on the preservation of bone mass. In this study, we analysed the relationship between testosterone concentration and bone metabolism. Moreover, we assessed the impact of one-year compensation of testosterone deficiency in elderly men on bone metabolism and bone mineral density. Read More

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http://dx.doi.org/10.5603/NMR.a2018.0002DOI Listing
September 2018
29 Reads