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Nutr J 2021 Jun 2;20(1):49. Epub 2021 Jun 2.

Health education group, Jahad Daneshgahi, Ahvaz, Khuzestan, Iran.

Background: It is suggested that vitamin D may have a beneficial role in male reproduction. The male reproductive system is a target tissue for vitamin D. This study will aim to evaluate the effects of vitamin D supplementation on sperm parameters, seminal and serum levels of oxidative stress and serum endocrine factors in asthenospermia infertile men. Read More

Basic Clin Androl 2021 Jun 3;31(1):13. Epub 2021 Jun 3.

Systems Biology Group Lab, Rome, Italy.

Background: Androgen deficiency affects men in the adulthood, causing several harmful effects at the reproductive and behavioural levels. Since aromatase is an enzyme that catalyses the conversion of androgens to estrogens, and it is responsible for an adequate balance of both sex hormones in males and females, the administration of molecules acting as down modulators may contribute to restore an abnormal enzymatic activity. A prospective pilot study was carried out to investigate the effect of D-chiro-inositol, a putative aromatase down-modulator, on serum levels of testosterone, estradiol, estrone, dehydroepiandrosterone and epiandrosterone from a group of adult male volunteers. Read More

Cureus 2021 Apr 15;13(4):e14511. Epub 2021 Apr 15.

Reproductive Medicine, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, IND.

Background Hypovitaminosis D has been linked with poor semen parameters and endocrinological factors in male infertility. This study aimed to analyze the association of serum vitamin D levels and reproductive hormones such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone (TT) with the semen parameters in a cohort of infertile men. Methodology In this study, 224 infertile men (aged 18-45 years) were recruited after applying inclusion and exclusion criteria. Read More

Front Endocrinol (Lausanne) 2021 14;12:666687. Epub 2021 Apr 14.

Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany.

Vitamin D deficiency is very common in women of reproductive age. Studies in animals suggests a link between vitamin D and reproductive hormone biosynthesis. A systematic analysis of the correlation of reproductive hormones in reproductive-aged women with both total and free vitamin D was, however, not done so far. Read More

Fed Pract 2021 Mar;38(3):121-127

is an Assistant Professor in the Division of Endocrinology, Metabolism and Nutrition at University of Washington School of Medicine, Seattle. is a Pharmacist; is the Pharamaceconomics Program Manager in Pharmacy; is the Formulary Program Manager; all at the US Department of Veterans Affairs Puget Sound Health Care System. is Professor Emeritus of Medicine in the Division of Gerontology and Geriatric Medicine and at the University of Washington School of Medicine.

Background: Testosterone therapy is indicated for the treatment of hypogonadism. Evidence-based guidelines recommend testosterone treatment only for men with symptoms and signs of testosterone deficiency and consistently low serum testosterone concentrations; luteinizing hormone (LH) and follicle-stimulating hormone (FSH) measurements and discussion of risks and benefits of testosterone prior to therapy. However, the US Department of Veterans Affairs (VA) Office of the Inspector General (OIG) report found that health care providers were adhering poorly to guideline recommendations for the diagnosis and treatment of men with hypogonadism. Read More

Hum Reprod 2021 05;36(6):1469-1480

Fertility Clinic, Skive Regional Hospital, and the Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) play complementary roles in follicle development and ovulation via a complex interaction in the hypothalamus, anterior pituitary gland, reproductive organs, and oocytes. Impairment of the production or action of gonadotropins causes relative or absolute LH and FSH deficiency that compromises gametogenesis and gonadal steroid production, thereby reducing fertility. In women, LH and FSH deficiency is a spectrum of conditions with different functional or organic causes that are characterized by low or normal gonadotropin levels and low oestradiol levels. Read More

Clin J Gastroenterol 2021 Mar 14. Epub 2021 Mar 14.

Department of Surgery, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan.

Isolated adrenocorticotropic hormone (ACTH) deficiency is a rare immune-related adverse event associated with immunotherapy using immune checkpoint inhibitors for malignant tumors. A 68-year-old man had previously undergone a complete gastrectomy with regional lymph-node dissection for remnant gastric cancer, with a final diagnosis of T4aN2M1, Stage IV. Because he developed lymph-node metastases during postoperative chemotherapy using S-1 plus oxaliplatin, he was treated with ramucirumab plus nab-paclitaxel. Read More

Vitam Horm 2021 8;115:585-609. Epub 2021 Feb 8.

Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Late-onset hypogonadism, resulting from deficiency in serum testosterone (T), affects the health and quality of life of millions of aging men. T is synthesized by Leydig cells (LCs) in response to luteinizing hormone (LH). LH binds LC plasma membrane receptors, inducing the formation of a supramolecular complex of cytosolic and mitochondrial proteins, the Steroidogenic InteracTomE (SITE). Read More

Front Pediatr 2020 2;8:600962. Epub 2021 Feb 2.

Department of Paediatric Endocrinology, Great Ormond Street Hospital for Children, London, United Kingdom.

Congenital hypopituitarism (CH) is characterized by a deficiency of one or more pituitary hormones. The pituitary gland is a central regulator of growth, metabolism, and reproduction. The anterior pituitary produces and secretes growth hormone (GH), adrenocorticotropic hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, and prolactin. Read More

Int J Oral Maxillofac Surg 2021 Feb 23. Epub 2021 Feb 23.

Department of Oral Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China. Electronic address:

Idiopathic condylar resorption (ICR) is an aggressive form of temporomandibular joint disease that most frequently presents in adolescent girls during the pubertal growth spurt. Although numerous studies have indicated that the etiopathogenesis of ICR may be related to estrogen deficiency, the decisive role of estrogens remains controversial, and other sex hormone disturbances have not yet been investigated in this regard. Therefore, the aim of this study was to ascertain the role of serum estrogen levels and also the roles of other sex hormones in the pathogenesis of ICR. Read More

Andrologia 2020 Nov 21;52(10):e13759. Epub 2020 Jul 21.

Department of Urology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.

In this study, the efficiency of intracavernosal alprostadil + oral clomiphene citrate (CC) treatment in late-onset hypogonadism (LOH) accompanied by penile vasculogenic erectile dysfunction (PVED) in patients irresponsive to phosphodiesterase type 5 inhibitor treatment was evaluated. A total of 31 patients with concurrent PVED and LOH were included in the study. The patients were given intracavernosal alprostadil (10-20 μg) and oral CC (50 mg) every day for 12 weeks. Read More

Reprod Biol Endocrinol 2021 Feb 13;19(1):22. Epub 2021 Feb 13.

Reproductive Endocrinology and Regulation Laboratory West China Second University Hospital, Sichuan University, #20 Section 3, Ren Min Nan Road, Chengdu, 610041, Sichuan, China.

Background: Irisin, which is cleaved from fibronectin type III domain-containing protein 5 (Fndc5), plays an important role in energy homeostasis. The link between energy metabolism and reproduction is well known. However, the biological actions of irisin in reproduction remain largely unexplored. Read More

Front Horm Res 2021 Feb 8;54:1-11. Epub 2021 Feb 8.

Division of Endocrinology, Department of Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA,

Hypothalamic-pituitary (HP) dysfunctions are commonly reported complications in survivors of childhood cancer. These include growth hormone deficiency, luteinizing hormone/follicle-stimulating hormone deficiency, thyroid-stimulating hormone deficiency, adrenocorticotropic hormone deficiency, central precocious puberty, hyperprolactinemia, and central diabetes insipidus. Local tumor invasion and surgical or radiation-induced injury represent the highest risk factors. Read More

Evid Based Complement Alternat Med 2021 5;2021:6696234. Epub 2021 Jan 5.

Sichuan Engineering Research Center for Medicinal Animals, Chengdu, Sichuan 610031, China.

Objective: Modern research shows that Haima Duobian pill (HDP) can relieve the kidney yang deficiency syndrome (KYDS), but the mechanism is still unclear. The aim of this work was to study the effects of HDP in a rat model of KYDS.

Materials And Methods: The network pharmacology methods were used to predict the therapeutic effects of Haima Duobian pill. Read More

Int J Fertil Steril 2021 Jan 19;15(1):1-7. Epub 2021 Jan 19.

Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Background: Follicle-stimulating hormone (FSH) plays a crucial role in spermatogenesis; in this study, we assessed the effect of recombinant human FSH (rhFSH) on sperm parameters, chromatin status and clinical outcomes of infertile oligozoospermic men candidates for intracytoplasmic sperm injection (ICSI).

Materials And Methods: This interventional randomized clinical trials (IRCT) included 40 infertile oligozoospermic men undergoing ICSI. These individuals were randomized into two groups: 20 men received rhFSH drug for three months and the other 20 men who did not receive rhFSH drug were considered the control group. Read More

J Sex Med 2021 02 27;18(2):256-264. Epub 2020 Nov 27.

Department of Urology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

Background: SARS-CoV-2 which causes coronavirus disease 2019 (COVID-19) binds to angiotensin-converting enyzme 2 (ACE2) and enters the host cell. ACE2 protein is expressed highly in the testis.

Aim: The aim of this study was to compare male reproductive hormones such as total testosterone (TT), luteinizing hormone (LH), follicular stimulant hormone (FSH), and prolactin between patients with COVID-19, age-matched cases with non-COVID-19 respiratory tract infection, and age-matched controls. Read More

Bone Marrow Transplant 2021 Jun 16;56(6):1422-1425. Epub 2021 Jan 16.

Department of Pediatric Hematology and Oncology, Timone Enfants Hospital and Aix-Marseille University, Marseille, France.

We included 255 patients from the L.E.A. Read More

Zhejiang Da Xue Xue Bao Yi Xue Ban 2020 Dec;49(6):697-704

College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 311400, China.

Objective: To investigate the effect of Chinese medicine Wubi Shanyao pills on sexual function of kidney-yang-deficiency mice induced by hydrocortisone.

Methods: Male Kunming mice were injected with hydrocortisone for 10 days to prepare the kidney-yang-deficiency model, and administrated with Wubi Shanyao pills (0.91, 1. Read More

Am J Physiol Endocrinol Metab 2021 03 11;320(3):E496-E511. Epub 2021 Jan 11.

Department of Cell Biology, Physiology and Immunology, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain.

Tachykinin (TAC) signaling is an important element in the central control of reproduction. TAC family is mainly composed of substance P (SP), neurokinin A (NKA), and NKB, which bind preferentially to NK1, NK2, and NK3 receptors, respectively. While most studies have focused on the reproductive functions of NKB/NK3R, and to a lesser extent SP/NK1R, the relevance of NK2R, encoded by , remains poorly characterized. Read More

Geriatr Gerontol Int 2021 Feb 6;21(2):268-275. Epub 2021 Jan 6.

Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries Co., Ltd., Beijing, China.

Aim: The aim of this study was to investigate the effect of oyster oligopeptide (OOP) at different doses on testosterone secretion and its regulating mechanism in partial androgen deficiency syndrome of aging male.

Methods: The cyclophosphamide-induced partial androgen deficiency syndrome of the aging male rats were treated with a low, medium and high dose of OOP for 6 weeks.

Results: Cyclophosphamide could decrease levels of total testosterone and luteinizing hormone in serum, and testosterone and glutathione peroxidase in testis, and increase malondialdehyde, and downregulate the mRNA expression of steroidogenic acute regulatory protein, steroidogenic acute regulatory-related lipid transfer domain 7 and P450 cholesterol side chain cleavage enzyme in testis (P < 0. Read More

Urol Oncol 2021 Jan 1. Epub 2021 Jan 1.

The University of Kansas Health System-Department of Urology, Kansas City, KS. Electronic address:

Background: Prior studies have demonstrated declines in androgen levels in men with cancer and patients undergoing anesthesia and surgery. In this study, we hypothesized that decreased serum androgen levels are prevalent in male patients undergoing radical cystectomy (RC) for bladder cancer and that it persists in the postoperative period. We characterized perioperative androgen hormonal profiles and examined for associated changes indicative of sarcopenia on computed tomography scans in men undergoing RC. Read More

Environ Toxicol 2021 May 17;36(5):789-799. Epub 2020 Dec 17.

School of Public Health, Beihua University, Jilin, China.

With the aggravation of environmental pollution, the incidence of infertility is increasing. Ginsenoside Rg1 is a monomer component extracted from Panax ginseng. It has been found that Ginsenoside Rg1 is able to prevent premature ovarian failure and delay testicular senescence. Read More

J Clin Med 2020 Nov 28;9(12). Epub 2020 Nov 28.

Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Málaga, Spain.

Obesity is associated with decreased circulating testosterone levels, the main male sex hormone. However, there are a number of different male sex hormones whose dynamics remain poorly understood regarding this pathology. In this regard, 17 hydroxyprogesterone (17-OH progesterone), as an important precursor of testosterone synthetized in testes and adrenal glands, could play an essential role in testosterone deficiency in male obesity. Read More

Aging (Albany NY) 2020 11 21;12(24):26012-26028. Epub 2020 Nov 21.

Institute of Reproductive Health/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Late-onset hypogonadism (LOH) is a syndrome in middle-aged and elderly men caused by age-related testosterone deficiency. Age-related change of total testosterone (TT) of Asian males is different from Caucasian population, suggesting difference for LOH identification in Asians. A nationwide cross-sectional study involving six centers in China was conducted. Read More

Womens Health (Lond) 2020 Jan-Dec;16:1745506520969606

Department of Endocrinology, Institute of Medicine, People's Friendship University of Russia, Moscow, Russia.

Objectives: to evaluate and compare clinical presentations, medical history, and laboratory data of patients with polycystic ovary syndrome, including vitamin 25(OH)D3 level.

Methods: In total, 81 patients were examined. The patient group included 51 patients with signs of polycystic ovary syndrome. Read More

Front Endocrinol (Lausanne) 2020 29;11:526287. Epub 2020 Sep 29.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.

Elevated 17-hydroxyprogesterone may be caused by congenital adrenal hyperplasia, ovarian or adrenal tumors. A positive cosyntropin stimulation test result for 17-hydroxyprogesterone may be found in functional or non-functional tumors and be related to tumor size. Here, we present a case of a 36-year-old woman with a 4-year history of infertility. Read More

Turk J Pediatr 2020 ;62(5):826-830

Departments of Pediatric Endocrinology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.

Background: Aromatase deficiency leading to virilization in mother and female fetuses during pregnancy is a rare disease. It is characterized by impaired estrogen production, increased gonadotropins, and ovarian cysts.

Case: Herein, we report a clinical phenotype of the virilized female due to a novel compound heterozygous variant in CYP19A1 [IVS10 + 1 G > A; c. Read More

Niger J Physiol Sci 2020 Jun 30;35(1):46-51. Epub 2020 Jun 30.

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Reproductive dysfunction following insulin deficiency in Diabetes Mellitus has been well reported among diabetic patients. However, the mechanism through which Diabetes alters reproductive function remains oblivion. While most studies have focused on diabetes mellitus in male subjects, there have been cases on altered reproductive functions in females. Read More

Indian J Endocrinol Metab 2020 May-Jun;24(3):265-269. Epub 2020 Jun 30.

Department of Endocrinology, JIPMER, Dhanvantri Nagar, Gorimedu, Puducherry, India.

Context: Thyroid hormones play an important role in reproductive and sexual function in both sexes. Comprehensive information on the ill-effects of hypothyroidism on Leydig cell, Sertoli cell and germ cell function is lacking in the existing literature.

Aims: To investigate the effect of primary hypothyroidism and its treatment on testicular function - Sertoli cell, Leydig cells, seminal fluid and spermatozoa. Read More

Int J Mol Sci 2020 Oct 11;21(20). Epub 2020 Oct 11.

Department of Biochemistry, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences, 194223 Saint Petersburg, Russia.

Low-molecular-weight agonists of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptor (LHCGR), which interact with LHCGR transmembrane allosteric site and, in comparison with gonadotropins, more selectively activate intracellular effectors, are currently being developed. Meanwhile, their effects on testicular steroidogenesis have not been studied. The purpose of this work is to perform a comparative study of the effects of 5-amino---butyl-4-(3-(1-methylpyrazole-4-carboxamido)phenyl)-2-(methylthio)thieno[2,3-] pyrimidine-6-carboxamide (TP4/2), a LHCGR allosteric agonist developed by us, and hCG on adenylyl cyclase activity in rat testicular membranes, testosterone levels, testicular steroidogenesis and spermatogenesis in young (four-month-old), aging (18-month-old) and diabetic male Wistar rats. Read More