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    1 OF 41

    In Vitro Fertilization Using Luteinizing Hormone-Releasing Hormone Injections Resulted in Healthy Triplets without Increased Attack Rates in a Hereditary Angioedema Case.
    Case Reports Immunol 2018 13;2018:2706751. Epub 2018 Feb 13.
    Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, İzmir, Turkey.
    Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The management of pregnant patients with C1-INH-HAE is a challenge for the physician. Intravenous plasma-derived nanofiltered C1-INH (pdC1INH) is the only recommended option throughout pregnancy, postpartum, and breastfeeding period. Read More

    Short-term Assessment of HSCT Effects on the Hypothalamus-Pituitary Axis in Pediatric Thalassemic Patients.
    Arch Iran Med 2018 Feb 1;21(2):56-60. Epub 2018 Feb 1.
    Hematology-Oncology and Stem Cell Transplantation Research Center of Tehran University of Medical Sciences, Tehran, Iran.
    Background: Beta thalassemia major (BTM) and its treatment by hematopoietic stem cell transplantation (HSCT) may have deleterious effects on the endocrine systems. We assessed endocrine complications of HSCT in pediatric patients for 3 months.

    Methods: In 20 (6 female) pediatric major thalassemic patients (mean age of 10. Read More

    GONADOPENIA AND AGING IN MEN.
    Endocr Pract 2018 Apr;24(4):375-385
    Objective: The decrease in testosterone levels that occurs with aging has become an important clinical issue both due to the growth of the geriatric population and patient interest in testosterone therapy. The decision to assess for testosterone deficiency and the ability to determine whether the benefits exceed the risks require a comprehensive evaluation of the aging patient. This article is part of a series of papers focused on the endocrinology of aging. Read More

    Undetectable high-density lipoprotein cholesterol in acute malaria.
    J Clin Lipidol 2018 Mar 9. Epub 2018 Mar 9.
    Guy's, St Thomas' and Lewisham and Greenwich Trust, St. Thomas' Hospital, London, United Kingdom.
    We report the case of a 39-year-old West African man in whom high-density lipoprotein cholesterol (HDL-C) was identified as undetectable at <0.08 mmol/L. Total cholesterol in the same sample was 2. Read More

    S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism.
    J Sex Med 2018 Mar 29. Epub 2018 Mar 29.
    Department of Urology, University of Miami, Miami, FL, USA. Electronic address:
    Background: Excess reactive oxygen species and reactive nitrogen species are implicated in male infertility and impaired spermatogenesis.

    Aim: To investigate the effect of excess reactive nitrogen species and nitrosative stress on testicular function and the hypothalamic-pituitary-gonadal axis using the S-nitrosoglutathione reductase-null (Gsnor) mouse model.

    Methods: Testis size, pup number, and epididymal sperm concentration and motility of Gsnor mice were compared with those of age-matched wild-type (WT) mice. Read More

    Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis.
    J Clin Invest 2018 Mar 26. Epub 2018 Mar 26.
    Institute of Reproductive and Developmental Biology (IRDB), Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.
    Spermatogenesis is regulated by the 2 pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This process is considered impossible without the absolute requirement of LH-stimulated testicular testosterone (T) production. The role of FSH remains unclear because men and mice with inactivating FSH receptor (FSHR) mutations are fertile. Read More

    Hormonal, metabolic and skeletal phenotype of Schaaf-Yang syndrome: a comparison to Prader-Willi syndrome.
    J Med Genet 2018 Mar 1. Epub 2018 Mar 1.
    Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA.
    Background: Nonsense and frameshift mutations in the maternally imprinted, paternally expressed gene located in the Prader-Willi critical region 15q11-15q13, have been reported to cause Schaaf-Yang syndrome (SYS), a genetic disorder that manifests as developmental delay/intellectual disability, hypotonia, feeding difficulties and autism spectrum disorder. Prader-Willi syndrome (PWS) is a genetic disorder characterised by severe infantile hypotonia, hypogonadotrophic hypogonadism, early childhood onset obesity/hyperphagia, developmental delay/intellectual disability and short stature. Scoliosis and growth hormone insufficiency are also prevalent in PWS. Read More

    The SET protein promotes androgen production in testicular Leydig cells.
    Andrology 2018 Feb 26. Epub 2018 Feb 26.
    State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
    Approximately 40% of middle-aged men exhibit symptoms of late-onset hypogonadism (LOH). However, the mechanism of androgen deficiency is still currently unclear. As shown in our previous studies, the SET protein is expressed in testicular Leydig cells and ovarian granule cells. Read More

    Homozygous nonsense mutation Trp28X in the LHB gene causes male hypogonadism.
    J Assist Reprod Genet 2018 Feb 23. Epub 2018 Feb 23.
    State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
    Purpose: The purpose of this study was to investigate a novel mutation in the luteinizing hormone beta-subunit (LHB) gene in one male patient with hypogonadism due to selective luteinizing hormone (LH) deficiency.

    Methods: Sanger sequencing of one 28-year-old man born to consanguineous parents was performed. Treatment with human chorionic gonadotropin (hCG) (2000 IU, twice a week) was initiated for 3 months, followed by 5000 IU weekly to date. Read More

    FSH may be a useful tool to allow early diagnosis of Turner syndrome.
    BMC Endocr Disord 2018 Feb 7;18(1). Epub 2018 Feb 7.
    Department of Medical Genetics, FCM, Unicamp, Rua Tessalia Vieira de Camargo, 126, Campinas, SP, 13083-887, Brazil.
    Background: Ultrasensitive assays to measure pre-pubertal gonadotropins levels could help identify patients with Turner syndrome (TS) in mid-childhood, but studies in this field are scarce. The aim of this study was to analyze gonadotropins levels in girls with TS throughout childhood.

    Methods: Retrospective longitudinal study conducted with 15 girls with TS diagnosed with < 5 years whose FSH and LH measures were available since then. Read More

    Isolated follicle stimulated hormone deficiency in male: case report.
    BMC Res Notes 2018 Jan 15;11(1):24. Epub 2018 Jan 15.
    Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka.
    Background: Recent rapid advances in assisted reproductive health technologies enables couples with subfertility to conceive through various intervention. Majority of treatment modalities target the female partner. However it is important to identify and treat male factor subfertility right at the outset. Read More

    The assessment of testosterone and radioisotopic index of bone metabolism and bone mineral density in men with testosterone deficiency after one year of testosterone therapy.
    Nucl Med Rev Cent East Eur 2018 Jan 10. Epub 2018 Jan 10.
    Department of Radiological and Isotopic Diagnosis and Therapy, Medical University of Lodz, 113 Zeromskiego Street, 90-549 Lodz, Poland.
    Background: Testosterone deficiency in men is characterized by typical symptoms of hypogonadism and negative influence on the preservation of bone mass. In this study, we analysed the relationship between testosterone concentration and bone metabolism. Moreover, we assessed the impact of one-year compensation of testosterone deficiency in elderly men on bone metabolism and bone mineral density. Read More

    Daily subcutaneous testosterone for management of testosterone deficiency.
    Front Biosci (Elite Ed) 2018 Mar 1;10:334-343. Epub 2018 Mar 1.
    Djehuty Biomed Consulting, 106 Rugged Dr., Red Oak, TX 75154.
    Testosterone deficiency (TD) is a public health concern, a predictor of metabolic syndrome, and is associated with an increased all-cause and cardiovascular mortality. Testosterone deficiency in men is treated by a variety of methods including injectable testosterone compounds, patches, gels, pellets, and oral preparations. The use of testosterone alone has been linked to various adverse effects including, infertility, testicular atrophy, erythropoiesis, and gynecomastia. Read More

    Recombinant luteinizing hormone supplementation to recombinant follicle stimulating hormone therapy in gonadotropin releasing hormone analogue cycles: what is the evidence?
    Curr Med Res Opin 2018 May 15;34(5):881-886. Epub 2018 Jan 15.
    c Reproductive Medicine, Department of Obstetrics and Gynecology , Hadassah-Hebrew University Medical Center , Ein-Kerem , Jerusalem , Israel.
    Objective: To look into current evidence exploring the added value of rLH supplementation to rFSH in GnRH analogues cycles, to identify groups of women that still have no evidence for adjuvant rLH therapy and to discuss ways that may advance research on this topic.

    Methods: Eight systematic reviews and meta-analyses exploring the benefit for pregnancy achievement of rLH supplementation, excluding other LH activity preparations, to GnRH analogues cycles in the ART setting were thoroughly evaluated.

    Results: Evidence exists to show that rLH supplementation seems to have added value for pregnancy achievement in women with poor ovarian response and in women ≥35 years of age employing the GnRH agonist protocol, while the evidence is still debatable when the GnRH antagonist is administered. Read More

    Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea.
    J Endocr Soc 2017 Nov 16;1(11):1362-1371. Epub 2017 Oct 16.
    Reproductive Endocrinology Department, Le Kremlin-Bicêtre, F-94275, France.
    Context: Hyperprolactinemia-induced hypogonadotropic amenorrhea (hPRL-HA) is a major cause of hypothalamic gonadotrophin-releasing hormone (GnRH) deficiency in women. In hyperprolactinemic mice, we previously demonstrated that hypothalamic kisspeptin (Kp) expression was diminished and that Kp administration restored hypothalamic GnRH release, gonadotropin secretion, and ovarian cyclicity, suggesting that Kp neurons could also play a role in hPRL-HA.

    Objective: To study the effect of Kp-10 on the gonadotropic-ovarian axis in women with hPRL-HA. Read More

    High risk of hypogonadism in young male cancer survivors.
    Clin Endocrinol (Oxf) 2018 Mar 10;88(3):432-441. Epub 2018 Jan 10.
    Molecular Reproductive Medicine Unit, Department of Translational Medicine, Lund University, Malmö, Sweden.
    Objective: Cancer and its treatment in childhood and young adulthood can cause hypogonadism, leading to increased risk of long-term morbidity and mortality. The aim of this study was to evaluate the risk of presenting with biochemical signs of hypogonadism in testicular cancer survivors (TCS) and male childhood cancer survivors (CCS) in relation to the type of treatment given.

    Design: Case-control study. Read More

    Can Tangier disease cause male infertility? A case report and an overview on genetic causes of male infertility and hormonal axis involved.
    Mol Genet Metab 2018 Jan 26;123(1):43-49. Epub 2017 Nov 26.
    General Director of Azienda Ospedaliera Ospedali Riuniti Marche Nord, Pesaro, Italy. Electronic address:
    Tangier disease is an autosomal recessive disorder caused by mutations in the ABCA1 gene and characterized by the accumulation of cholesteryl ester in various tissues and a near absence of high-density lipoprotein. The subject in this investigation was a 36-year-old Italian man with Tangier disease. He and his wife had come to the In Vitro Fertilization Unit, Pesaro Hospital (Azienda Ospedaliera Ospedali Riuniti Marche Nord) seeking help regarding fertility issues. Read More

    Reproductive Hormone Levels Predict Changes in Frailty Status in Community-Dwelling Older Men: European Male Ageing Study Prospective Data.
    J Clin Endocrinol Metab 2018 Feb;103(2):701-709
    Andrology Research Unit, Division of Diabetes, Endocrinology, and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
    Context: Clinical sequelae of androgen deficiency share common features with frailty. Evidence supporting the role of androgens in the development of frailty is limited and conflicting.

    Objective: To determine associations between male reproductive hormones and prospective changes in frailty status. Read More

    Elevated luteinizing hormone despite normal testosterone levels in older men-natural history, risk factors and clinical features.
    Clin Endocrinol (Oxf) 2018 Mar 25;88(3):479-490. Epub 2017 Dec 25.
    Manchester Academic Health Sciences Centre, Faculty of Medical and Human Sciences, Institute of Human Development, Centre for Endocrinology and Diabetes, Andrology Research Unit, University of Manchester, Manchester, UK.
    Objective: Elevated luteinizing hormone (LH) with normal testosterone (T) suggests compensated dysregulation of the gonadal axis. We describe the natural history, risk factors and clinical parameters associated with the development of high LH (HLH, LH >9.4 U/L) in ageing men with normal T (T ≥ 10. Read More

    Individual testosterone decline and future mortality risk in men.
    Eur J Endocrinol 2018 Jan 24;178(1):123-130. Epub 2017 Oct 24.
    Department of Growth and Reproduction.
    Objective: Male aging is characterized by a decline in testosterone (TS) levels with a substantial variability between subjects. However, it is unclear whether differences in age-related changes in TS are associated with general health. We investigated associations between mortality and intra-individual changes in serum levels of total TS, SHBG, free TS and LH during a ten-year period with up to 18 years of registry follow-up. Read More

    Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice.
    Cell Physiol Biochem 2017 4;43(3):1064-1076. Epub 2017 Oct 4.
    Institute of Biomedicine, University of Turku, Turku, Finland.
    Background/aims: Physiological role of luteinizing hormone (LH) and its receptor (LHCGR) in adrenal remains unknown. In inhibin-α/Simian Virus 40 T antigen (SV40Tag) (inhα/Tag) mice, gonadectomy-induced (OVX) elevated LH triggers the growth of transcription factor GATA4 (GATA4)-positive adrenocortical tumors in a hyperplasia-adenoma-adenocarcinoma sequence.

    Methods: We investigated the role of LHCGR in tumor induction, by crossbreeding inhα/Tag with Lhcgr knockout (LuRKO) mice. Read More

    Vitamin D and Testosterone in Healthy Men: A Randomized Controlled Trial.
    J Clin Endocrinol Metab 2017 Nov;102(11):4292-4302
    Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria.
    Context: Available evidence shows an association of vitamin D with androgen levels in men. However, results from preliminary randomized controlled trials (RCTs) are conflicting.

    Objective: To evaluate whether vitamin D supplementation increases total testosterone (TT) levels in healthy men. Read More

    The Genetic Basis of Delayed Puberty.
    Neuroendocrinology 2018 18;106(3):283-291. Epub 2017 Sep 18.
    The genetic control of puberty remains an important but mostly unanswered question. Late pubertal timing affects over 2% of adolescents and is associated with adverse health outcomes including short stature, reduced bone mineral density, and compromised psychosocial health. Self-limited delayed puberty (DP) is a highly heritable trait, which often segregates in an autosomal dominant pattern; however, its neuroendocrine pathophysiology and genetic regulation remain unclear. Read More

    Hypoluteoidism in a dog associated with recurrent mammary fibroadenoma stimulated by progestin therapy.
    Acta Vet Scand 2017 Sep 6;59(1):55. Epub 2017 Sep 6.
    Section of Obstetrics and Gynecology, Department of Veterinary Medicine, University of Sassari, Via Vienna n.2, 07100, Sassari, Italy.
    Background: Hypoluteoidism in the bitch is characterized by insufficient production and secretion of progesterone by the corpora lutea. It is a rare pathologic condition and during pregnancy, it leads to embryonic resorption or fetal abortion. Supplementary therapy with progestins is indicated during pregnancy to obtain delivery of vital puppies but unwarranted side effects of such treatment are poorly documented. Read More

    Secondary Adrenal Insufficiency Following Nivolumab Therapy in a Patient with Metastatic Renal Cell Carcinoma.
    Tokai J Exp Clin Med 2017 Sep 20;42(3):115-120. Epub 2017 Sep 20.
    Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Iseharashi, Kanagawa 259-1193, Japan.
    Currently, nivolumab (an anti-programmed cell death-1 receptor monoclonal antibody) is available for many types of advanced cancers in Japan. However, there have been few detailed case reports about endocrine-related adverse events of this therapy. Here, we report a patient with metastatic renal cell carcinoma who presented with secondary adrenal insufficiency following nivolumab therapy. Read More

    Taurine Improves Sexual Function in Streptozotocin-Induced Diabetic Rats.
    Adv Exp Med Biol 2017 ;975:307-318
    Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, 110866, People's Republic of China.
    Previous studies have identified that diabetic erectile dysfunction is associated with androgen and nitric oxide deficiency resulting from hyperglycemia. It has been demonstrated that taurine can stimulate testosterone secretion, increase nitric oxide synthase (NOS) activity and nitric oxide (NO) production, and reduce blood glucose levels in the diabetic animals. Furthermore, recent studies have found that taurine relaxes both the corpus cavernosum and the vasculature. Read More

    Leydig cell dysfunction, systemic inflammation and metabolic syndrome in long-term testicular cancer survivors.
    Eur J Cancer 2017 10 31;84:9-17. Epub 2017 Jul 31.
    Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
    Background: Twenty to thirty percent of testicular cancer (TC) survivors have elevated serum levels of luteinising hormone (LH) with or without corresponding low testosterone levels (Leydig cell dysfunction) during clinical follow-up for TC. However, it remains to be clarified if this subgroup of TC survivors has an increased long-term risk of systemic inflammation and metabolic syndrome (MetS) when compared with TC survivors with normal Leydig cell function during follow-up.

    Patients And Methods: TC survivors with Leydig cell dysfunction and a control group of TC survivors with normal Leydig cell function during follow-up were eligible for participation in the study. Read More

    A role of alpha-tocopherol and phylloquinone in the modulation of uterine contractility and reproductive function in mouse models.
    Medicina (Kaunas) 2017 30;53(3):190-202. Epub 2017 May 30.
    Histopathology Department, University of Benin Teaching Hospital, Benin City, Nigeria.
    Background And Aim: Alpha-tocopherol has been implicated in reproduction processes, and deficiency of phylloquinone has been associated with serious complications in pregnancy. This study was therefore aimed at investigating the effects of phylloquinone and alpha-tocopherol on uterine contractility and female reproductive function using mouse models.

    Materials And Methods: Both in vivo and ex vivo animal models were employed and designed to assess changes on uterine contractility and reproductive functions in the non-pregnant uterus. Read More

    Curative effect of 1.88-mg and 3.75-mg gonadotrophin-releasing hormone agonist on stage III-IV endometriosis: Randomized controlled study.
    J Obstet Gynaecol Res 2017 Oct 14;43(10):1550-1554. Epub 2017 Jul 14.
    Central Laboratory, Peking University Shenzhen Hospital, Shenzhen, China.
    Aim: To compare the therapeutic effect of 1.88-mg and 3.75-mg gonadotrophin-releasing hormone agonist (GnRHa) in the treatment of stage III-IV endometriosis after laparoscopic surgery. Read More

    A child with hypertension and ambiguous genitalia - an uncommon variant of congenital adrenal hyperplasia: a case report.
    J Med Case Rep 2017 Jun 23;11(1):168. Epub 2017 Jun 23.
    Department of Biochemistry, Institute of Medicine (IOM), Kathmandu, Nepal.
    Background: Deficiency in 11β-hydroxylase as a cause of congenital adrenal hyperplasia is uncommon. It should be considered in the differential diagnosis of hypertension with virilization in any prepubescent child.

    Case Presentation: A 12-year-old Asian boy from eastern Nepal presented with pain in his abdomen and hypertension. Read More

    Prevalence of androgen deficiency in chronic spinal cord injury patients suffering from erectile dysfunction.
    Spinal Cord 2017 Jun 20. Epub 2017 Jun 20.
    Shafa Neuroscience Research Center, Khatam Al-Anbia Hospital, Tehran, Iran.
    Study Design: Retrospective cross-sectional study.

    Objectives: To estimate the prevalence of biochemical androgen deficiency in Iranian spinal cord injured men suffering from erectile dysfunction (ED) and to determine factors related to this problem.

    Setting: An andrology clinic of a teaching hospital in Tehran. Read More

    Gamma Knife radiosurgery for hypothalamic hamartoma preserves endocrine functions.
    Epilepsia 2017 06;58 Suppl 2:72-76
    Department of Functional Neurosurgery, Assistance Publique Hôpitaux de Marseille, La Timone Hospital, Aix-Marseille University, Marseille, France.
    Gamma Knife radiosurgery (GK) is an effective treatment for hypothalamic hamartoma. No precise data are available on the risk of endocrine side effects of this treatment. In this study, 34 patients with hypothalamic hamartoma (HH) were followed prospectively at the Department of Endocrinology, La Timone Hospital, Marseille, France, for a mean follow-up of >2 years (mean ± standard deviation [SD] 3. Read More

    Idiopathic hypogonadotropic hypogonadism reversal after testosterone replacement in a 34-year-old male.
    BMJ Case Rep 2017 Jun 5;2017. Epub 2017 Jun 5.
    Department of Endocrinology, Aga Khan University Hospital, Karachi, Pakistan.
    A 34-year-old male presented to the endocrinology clinic with the complaint of the absence of facial, axillary and pubic hairs. Further history revealed absent ejaculations and decreased early morning erections. The patient had no history of headaches, visual problems or anosmia. Read More

    Assessment of Hypogonadism in Men With Type 2 Diabetes: A Cross-Sectional Study From Saudi Arabia.
    Clin Med Insights Endocrinol Diabetes 2017 19;10:1179551417710209. Epub 2017 May 19.
    Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
    Background/objectives: A high incidence of hypogonadism in men with type 2 diabetes (T2D) has been globally reported. This study aimed to determining the frequency of hypogonadism and related risk factors among men with T2D in a single-site hospital in Saudi Arabia.

    Design And Methods: A cross-sectional study was performed on 157 men with T2D (between 30 and 70 years of age). Read More

    Hypogonadism in testicular cancer patients is associated with risk factors of cardiovascular disease and the metabolic syndrome.
    Andrology 2017 07 23;5(4):711-717. Epub 2017 May 23.
    Molecular Reproductive Medicine Unit, Department of Translational Medicine, Lund University, Malmö, Sweden.
    More than 95% of testicular cancer are cured but they are at increased long-term risk of cardiovascular disease. The risk of cardiovascular disease and treatment intensity was reported, but it is unknown whether this effect of cancer therapy is direct or indirect, mediated through androgen deficiency. Our aim was, therefore, to evaluate whether testicular cancer patients have increased the prevalence of risk factors of cardiovascular disease and if these risk factors are associated with hypogonadism and/or the cancer treatment given. Read More

    Impaired steroidogenesis in the testis of leptin-deficient mice (ob/ob -/-).
    Acta Histochem 2017 Jun 13;119(5):508-515. Epub 2017 May 13.
    Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
    The obesity and its comorbidities, including resistance to leptin, impacts the reproductive function. Testes express leptin receptors in the germ cells and Leydig cells. Then, leptin-deficient animals are obese and infertile. Read More

    [Cornelia de Lange Syndrome and multiple hormonal deficiency, an unusual association. Clinical case].
    Arch Argent Pediatr 2017 06;115(3):e170-e174
    Escuela de Medicina, Universidad Industrial de Santander.
    Cornelia de Lange syndrome is a genetic disease characterized by distinctive facial features, failure to thrive, microcephaly and several malformations associated. Its main endocrinological features are anomalies of the genitalia. We present a 13-year-old boy, who suffered from complicated aspiration pneumonia and showed Cornelia de Lange syndrome phenotype, with global developmental delay, suction-swallowing abnormalities, short stature and abnormal genitalia associated. Read More

    Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice.
    Endocrinology 2017 07;158(7):2168-2178
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602.
    Ras homolog gene family, member A (RhoA) is widely expressed throughout the female reproductive system. To assess its role in progesterone receptor-expressing cells, we generated RhoA conditional knockout mice RhoAd/d (RhoAf/f-Pgr-Cre+/-). RhoAd/d female mice had comparable mating activity, serum luteinizing hormone, prolactin, and estradiol levels and ovulation with control but were infertile with progesterone insufficiency, indicating impaired steroidogenesis in RhoAd/d corpus luteum (CL). Read More

    Estradiol deficiency is a risk factor for idiopathic benign paroxysmal positional vertigo in postmenopausal female patients.
    Laryngoscope 2018 Apr 7;128(4):948-953. Epub 2017 May 7.
    Department of Neurology, Medical Center for Vertigo and Balance Disorders, Changzheng Hospital, Second Military Medical University, Shanghai, China.
    Objectives/hypothesis: Although it is generally considered that benign paroxysmal positional vertigo (BPPV) is associated with changes in female sex hormone levels, no direct data have been reported until now. The purpose of this article was to provide direct data showing the distinct relationship between female sex hormone fluctuations and BPPV in postmenopausal female patients.

    Study Design: Prospective analysis in humans and basic research in animals. Read More

    Microdissection testicular sperm extraction in men with nonobstructive azoospermia: Experience of King Saud University Medical City, Riyadh, Saudi Arabia.
    Urol Ann 2017 Apr-Jun;9(2):136-140
    Department of Urology, Prince Mohammed Bin Abdulaziz Hospital, Riyadh, Saudi Arabia.
    Objectives: Microdissection testicular sperm extraction (micro-TESE) is an optimal technique of sperm extraction for intracytoplasmic sperm injection. This study is to present our experience in micro-TESE and evaluate the relation of its sperm retrieval rate (SRR) with patients' characteristics, testicular functions, and histological parameters as well as previous sperm retrieval interventions.

    Materials And Methods: We retrospectively reviewed records of 255 patients with nonobstructive azoospermia who underwent micro-TESE between 2011 and 2014. Read More

    The presence of symptoms of testosterone deficiency in the exercise-hypogonadal male condition and the role of nutrition.
    Eur J Appl Physiol 2017 Jul 3;117(7):1349-1357. Epub 2017 May 3.
    Department of Human Sciences, The Ohio State University, A054 PAES Building, 305 Annie and John Glenn Avenue, Columbus, OH, 43210, USA.
    Purpose: High volumes of aerobic exercise have been associated with reduced testosterone (T), known as the exercise-hypogonadal male condition (EHMC). Although the presence of low T has been identified, few studies have assessed the presence of androgen-deficient symptoms. The purpose of this investigation is to assess men exhibiting EHMC and evaluate their hypothalamic-pituitary-gonadal axis, the presence of hypogonadal symptoms, and also investigate a possible contribution of inadequate nutrition to the condition. Read More

    Dynamics of hormonal disorders following unilateral orchiectomy for a testicular tumor.
    Med Oncol 2017 May 7;34(5):84. Epub 2017 Apr 7.
    Department of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5 st., 02-781, Warsaw, Poland.
    Testicular tumors and their treatment interfere with homeostasis, hormonal status included. The aim of the study was to evaluate hormonal disorders of the pituitary-gonadal axis in men treated for testicular tumors. One hundred twenty-eight men treated for a unilateral testicular tumor at our institution were included. Read More

    Pulsatile GnRH Therapy May Restore Hypothalamus-Pituitary-Testis Axis Function in Patients With Congenital Combined Pituitary Hormone Deficiency: A Prospective, Self-Controlled Trial.
    J Clin Endocrinol Metab 2017 Jul;102(7):2291-2300
    Department of Endocrinology, Peking Union Medical College Hospital, Key Laboratory of Endocrinology, Ministry of Health, Beijing 100730, China.
    Context: The effectiveness of pulsatile gonadotropin-releasing hormone (GnRH) therapy in patients with congenital combined pituitary hormone deficiency (CCPHD) has not been investigated because of the limited number of patients, as well as these patients' presumed pituitary hypoplasia, poor gonadotrophic cell reserve, and impaired gonadotrophic response to GnRH.

    Objective: To assess the pituitary response to pulsatile GnRH therapy in men with CCPHD.

    Design: Prospective, self-controlled, 3-month clinical trial. Read More

    Long-Term Neonatal Estrogen Exposure Causes Irreversible Inhibition of LH Pulses by Suppressing Arcuate Kisspeptin Expression via Estrogen Receptors α and β in Female Rodents.
    Endocrinology 2017 09;158(9):2918-2929
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi 464-8601, Japan.
    Exposure to estrogen during the developmental period causes reproductive dysfunction in mammals, because the developing brain is highly sensitive to estrogens. In the present study, we report that long-term exposure to supraphysiological doses of estrogen during the neonatal critical period causes irreversible suppression of Kiss1/kisspeptin expression in the arcuate nucleus (ARC) via estrogen receptor-alpha (ERα) and ERβ, resulting in reproductive dysfunction in female rats. Daily estradiol-benzoate (EB) administration from days 0 to 10 postpartum caused persistent vaginal diestrus in female rats. Read More

    Anti-Müllerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH.
    J Clin Endocrinol Metab 2017 Apr;102(4):1102-1111
    Assistance Publique-Hôpitaux de Paris.
    Context: Isolated hypogonadotropic hypogonadism (IHH), characterized by gonadotropin deficiency and absent puberty, is very rare in women. IHH prevents pubertal ovarian stimulation, but anti-Müllerian hormone (AMH) and antral follicle count (AFC) have not been studied.

    Objectives: (1) To compare, in IHH vs controls, AMH, ovarian volume (OV), and AFC. Read More

    17α-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS.
    Endocr Pract 2017 May 22;23(5):576-582. Epub 2017 Feb 22.
    Objective: 17α-hydroxylase/17, 20-lyase deficiency (17OHD) is caused by mutations in the cytochrome P450 17A1 (CYP17A1) gene. To better understand 17OHD, a rare disease, we described the clinical features and performed CYP17A1 gene analysis in 8 affected Chinese patients.

    Methods: Patients with complete (7/8) or partial (1/8) 17OHD were derived from 6 families. Read More

    A study to evaluate the prevalence of hypogonadism in Indian males with Type-2 diabetes mellitus.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):64-70
    Global Medical Affairs, MSD Pharmaceuticals Private Limited, 10th Floor, Platina Building, C-59, G-Block, Bandra Kurla Complex, Mumbai, Maharashtra, India.
    Background: A high prevalence of hypogonadism in men with Type-2 diabetes mellitus (T2DM) has been reported worldwide.

    Objectives: To evaluate the prevalence of hypogonadism in Indian males with T2DM and assess the primary and secondary hypogonadism along with androgen deficiency.

    Materials And Methods: In this cross-sectional study, 900 men with T2DM were evaluated using androgen deficiency in aging male questionnaire. Read More

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