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J Inherit Metab Dis 2019 Jan;42(1):147-158

Metabolic Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.

Background: Transaldolase deficiency (TALDO-D) is a rare autosomal recessive inborn error of the pentose phosphate pathway. Since its first description in 2001, several case reports have been published, but there has been no comprehensive overview of phenotype, genotype, and phenotype-genotype correlation.

Methods: We performed a retrospective questionnaire and literature study of clinical, biochemical, and molecular data of 34 patients from 25 families with proven TALDO-D. Read More

Curr Diabetes Rev 2019 Feb 6. Epub 2019 Feb 6.

Internal Medicine Department, Endocrinology unit,Ain Shams University hospitals,Cairo. Egypt.

Introduction: T1DM is considered the most common chronic metabolic autoimmune disorder in childhood and adolescence as well as in early adulthood. It appears frequently during 12-13 years of age with distinctive features like immune-mediated chronic damage of pancreatic β-cells, leading eventually to partial, or mostly, absolute insulin deficiency. Insulin-like growth factor 1 (IGF-1) is a polypeptide consisting of 70 amino acids with insulin-like chemical structure. Read More

Discov Med 2018 Dec;26(145):243-249

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.

Congenital adrenal hyperplasia (CAH) resulting from 17α-hydroxylase/17,20-lyase deficiency (17-OHD) is an uncommon autosomal recessive disease. 17-OHD is caused by mutations in the cytochrome P450c17 gene (CYP17A1), and characterized by hypertension, hypokalemia, female sexual infantilism, or male pseudohermaphroditism. Here we report a case of a 19-year-old Chinese girl (46,XX) with 17-OHD, and analyze her clinical and molecular genetic characteristics. Read More

Int J Impot Res 2019 Jan 22. Epub 2019 Jan 22.

UMC Utrecht, Laboratory of Clinical Chemistry and Hematology, G03.550, Heidelberglaan 100, 3584CX, Utrecht, Netherlands.

Testosterone has effects on many organs and systems. The purpose of this study was to test the hypothesis that low testosterone is associated with changes in various non-cardiovascular biomarkers in men older than 40 who were tested for possible hypogonadism. We extracted data from 9939 outpatient men who were over 40 years old (median age 56) and who also had concurrent laboratory measurements of total testosterone and one or more biomarkers of interest: estradiol, uric acid, prostate-specific antigen (PSA), sex-hormone binding globulin (SHBG), luteinizing hormone, creatinine, bone alkaline phosphatase (BAP), creatine kinase, hemoglobin A1c, and 25-hydroxy-vitamin D, and body mass index (BMI). Read More

Neuro Endocrinol Lett 2018 Dec 22;39(5):363-370. Epub 2018 Dec 22.

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.

Objectives: Brain bio-energetic stability is required for optimal gonadal steroid positive-feedback activation of the gonadotropin-releasing hormone-I (GnRH-I)-pituitary luteinizing hormone (LH) neuroendocrine axis. Caudal hindbrain metabolic-sensory noradrenergic neurons counter energy deficiency by curtailing the mid-cycle LH surge. Central mu opioid receptors (mu-R) impose inhibitory effects of diverse physiological stimuli, including stress, on LH. Read More

J Pineal Res 2019 Jan 16:e12559. Epub 2019 Jan 16.

China Agricultural University, Beijing, P.R. China.

Melatonin is a natural molecule produced in the pineal gland and other tissues. It participates in numerous biological activities including the regulation of reproduction. However, the mechanism by which melatonin affects mammalian female reproductive performance is not fully investigated. Read More

Horm Res Paediatr 2019 Jan 9:1-10. Epub 2019 Jan 9.

Department of Paediatric Allergy and Immunology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey.

Background: The term "H syndrome" was coined to denote the major clinical findings, which include hyperpigmentation, hypertrichosis, hearing loss, hepatosplenomegaly, hyperglycaemia, hypogonadism, hallux flexion contractures, and short height.

Objective: To report the clinical, endocrinological, histochemical, and genetic findings of three siblings.

Methods: Skin and liver biopsies were taken to investigate the histochemical characteristics of hyperpigmented hypertrichotic skin lesions and massive hepatomegaly. Read More

Front Endocrinol (Lausanne) 2018 14;9:763. Epub 2018 Dec 14.

Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom.

Spermatogenesis is a concerted sequence of events during maturation of spermatogonia into spermatozoa. The process involves differential gene-expression and cell-cell interplay regulated by the key endocrine stimuli, i.e. Read More

Bioorg Med Chem Lett 2019 Feb 10;29(4):654-658. Epub 2018 Dec 10.

Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd., Fujisawa 251-8555, Japan.

The kisspeptin (Kp, Kp-54, metastin)/KISS1R system plays crucial roles in regulating the secretion of gonadotropin-releasing hormone. Continuous administration of nonapeptide Kp analogs caused plasma testosterone depletion, whereas bolus administration caused strong plasma testosterone elevation in male rats. To develop a new class of small peptide drugs, we focused on stepwise N-terminal truncation of Kp analogs and discovered potent pentapeptide analogs. Read More

J Gerontol A Biol Sci Med Sci 2018 Dec 17. Epub 2018 Dec 17.

Department of Pathology, Nagasaki University School of Medicine, Graduate School of Biomedical Sciences, Nagasaki, Japan.

The orexigenic hormone neuropeptide Y (NPY) plays a pivotal role in the peripheral regulation of fat metabolism. However, the mechanisms underlying the effects of sex on NPY function have not been extensively analyzed. In this study, we examined the effects of NPY deficiency on fat metabolism in male and female mice. Read More

Arch Esp Urol 2018 Dec;71(10):850-855

Department of Urology. Ataturk University Medical Faculty. Erzurum. Turkey.

Objectives: According to the WorldHealth Organization (WHO) definition, infertility is "thefailure of a sexually active, non-contracepting couple toachieve pregnancy in one year" and is a complicateddisorder with its medical, psychosocial and economicaspects. There is some proof that vitamin D deficiencyhas important effects on the male reproductive system.There are numerous animal trials and a limited numberof human trials investigating this topic. Read More

J Assist Reprod Genet 2018 Nov 22. Epub 2018 Nov 22.

Ottawa Hospital Research Institute, The Ottawa Hospital-General Campus, 501 Smyth Road, Box 511, Ottawa, K1H 8L6, Canada.

The aging-related decline in fertility is an increasingly pressing medical and economic issue in modern society where women are delaying family building. Increasingly sophisticated, costly, and often increasingly invasive, assisted reproductive clinical protocols and laboratory technologies (ART) have helped many older women achieve their reproductive goals. Current ART procedures have not been able to address the fundamental problem of oocyte aging, the increased rate of egg aneuploidy, and the decline of developmental potential of the eggs. Read More

Hormones (Athens) 2018 Dec 20;17(4):581-588. Epub 2018 Nov 20.

Istanbul Faculty of Medicine, Department of Pediatrics, Pediatric Endocrinology Unit, Istanbul University, Çapa 34093, Istanbul, Turkey.

Central precocious puberty (CPP) or early puberty (EP) is a rare entity in combined pituitary hormone deficiency (CPHD), the latter caused by mutations in pituitary transcription factor genes. The early onset of puberty in two patients with CPHD with POU1F1 gene mutation was evaluated. A 3-month-old boy was diagnosed with central hypothyroidism, and L-thyroxine was commenced. Read More

J Clin Transl Endocrinol 2018 Dec 26;14:25-33. Epub 2018 Sep 26.

Department of Medical Endocrinology and Metabolism, Rigshospitalet, National University Hospital, Copenhagen University, Copenhagen, Denmark.

Central hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH concentrations can be normal or even above the upper normal reference limit. Indeed, certain patients are at risk of developing CH, such as those with a pituitary adenoma or hypophysitis, those who have been treated for a childhood malignancy, have suffered a head trauma, sub-arachnoid hemorrhage or meningitis, and those who are on drugs capable to reduce TSH secretion. Read More

Life Sci 2019 Jan 7;216:129-139. Epub 2018 Nov 7.

Guangdong Engineering & Technology Research Center for Disease-Model Animals, Program in Cardiovascular Disease and Metabolism, the Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; Department of Biochemistry, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; Laboratary Animal Center, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. Electronic address:

Aims: This study aims to investigate the pathophysiological role and mechanism of pigment epithelium-derived factor (PEDF) deletion in ovarian damage.

Methods: Female PEDF-knockout mice and their wild-type littermates were used in this study. Relevant tests were performed at 8-10 weeks or 32 weeks of age. Read More

J Clin Med 2018 Oct 21;7(10). Epub 2018 Oct 21.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Polna 33, Poznan 60-535, Poland.

Premature ovarian insufficiency (POI) is hypogonadism associated with amenorrhea, increased levels of gonadotropins, and hypoestrogenism. Deficiency of estrogens may contribute to higher risk of cardiovascular diseases and death. POI patients present several risk factors for the development of cardiovascular diseases (CVD): endothelial dysfunction, abnormal lipid profile, insulin resistance, and insulin action disturbances. Read More

Med Sci Sports Exerc 2019 Mar;51(3):556-567

Research & Clinical Innovation, Royal Centre for Defence Medicine, Lichfield, UNITED KINGDOM.

Purpose: To explore the effects of the first all-female transantarctic expedition on hormonal axes pertinent to reproductive and metabolic function.

Methods: Six females (age, 28-36 yr; body mass index, 24.2 ± 0. Read More

Endocr Pract 2018 Dec 5;24(12):1030-1037. Epub 2018 Oct 5.

Objective: To evaluate pituitary function in men with a low screening prostate-specific antigen (PSA) of ≤0.1 ng/mL and test the hypothesis that low PSA is associated with hypogonadism alone or other hormone deficiency.

Methods: This was a case-control study evaluating the rates of hypogonadism and low insulin-like growth factor (IGF)-1 in a cohort of men with low or normal screening PSA level. Read More

Stem Cells Transl Med 2019 Jan 2;8(1):58-65. Epub 2018 Oct 2.

Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Exogenous testosterone therapy can be used to treat testosterone deficiency; however, it has several adverse effects including infertility due to negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis. Leydig stem cell (LSC) transplantation could provide a new strategy for treating testosterone deficiency, but clinical translatability of injecting stem cells inside the testis is not feasible. Here, we explore the feasibility of subcutaneously autografting LSCs in combination with Sertoli and myoid cells to increase testosterone. Read More

Nutr Metab (Lond) 2018 10;15:58. Epub 2018 Aug 10.

State Key Lab of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193 People's Republic of China.

Background: The effects of vitamin D on the immune function of laying hens are not well understood. This study investigated the effects of vitamin D (VD) on laying performance and immunological functions in laying hens under lipopolysaccharide (LPS) challenge.

Methods: In experiment one, 360 Jinghong-1 strain layers (32 weeks) were randomly divided into four groups with six replicates per group and 15 hens per replicate. Read More

Sex Med Rev 2018 Oct 26;6(4):618-623. Epub 2018 Jul 26.

Division of Urology, Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA; Department of Urology, Hackensack University Medical Center, Hackensack, NJ, USA. Electronic address:

Introduction: Over the last several decades, the opioid epidemic has become a national crisis, largely spurred by the spike in the use of prescription painkillers. With the epidemic came a concomitant rise in the incidence of opioid-induced androgen deficiency (OPIAD). Although OPIAD can significantly impact male sexual function and quality of life, it is an overlooked and poorly understood clinical entity that requires more attention from healthcare providers. Read More

Biochim Biophys Acta Mol Basis Dis 2018 Oct 23;1864(10):3292-3297. Epub 2018 Jul 23.

Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany. Electronic address:

Objectives: Female reproductive dysfunction occurs in patients with pathological loss of adipose tissue, i.e. lipodystrophy (LD). Read More

Eur J Endocrinol 2018 Sep 29;179(3):R143-R150. Epub 2018 Jun 29.

Department of Surgery and CancerInstitute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK

The two pituitary gonadotrophins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and in particular LH-stimulated high intratesticular testosterone (ITT) concentration, are considered crucial for spermatogenesis. We have revisited these concepts in genetically modified mice, one being the ()-knockout mouse (LuRKO), the other a transgenic mouse expressing in Sertoli cells a highly constitutively active mutated (Fshr-CAM). It was found that full spermatogenesis was induced by exogenous testosterone treatment in LuRKO mice at doses that restored ITT concentration to a level corresponding to the normal circulating testosterone level in WT mice, ≈5 nmol/L, which is 1. Read More

J Clin Endocrinol Metab 2018 Sep;103(9):3239-3249

Andros Men's Health Institutes, CV Arnhem, Netherlands.

Context: Luteinizing hormone-releasing hormone (LHRH) agonists have replaced estrogens for endocrine treatment of advanced prostate cancer (PC) because of cardiovascular side effects. The fetal estrogen estetrol (E4) may be safer for PC treatment and is expected to decrease testosterone (T) and prevent estrogen deficiency.

Objective: To investigate the safety and T-suppressive effect of E4 in healthy men. Read More

Front Public Health 2018 31;6:147. Epub 2018 May 31.

Facultad de Medicina, Universidad de los Andes, Santiago, Chile.

To describe and evaluate urinary hormone profiles in the luteal phase. Twenty-five healthy fertile women, with regular ovulatory pattern cycles as assessed by temperature and cervical mucus, at a university based center. Daily urinary hormonal assessment of luteinizing hormone, estrone glucuronide, and pregnanediol glucuronide. Read More

PLoS One 2018 24;13(5):e0197252. Epub 2018 May 24.

Department of Urology, Obihiro-Kosei General Hospital, Obihiro, Hokkaido, Japan.

Purpose: Intermittent androgen deprivation therapy is an effective treatment for metastatic prostate cancer. However, no study to date has evaluated the long-term outcomes of this treatment among patients with prostate cancer after radical prostatectomy. We retrospectively examined the treatment outcomes of patients with prostate-specific antigen recurrence who underwent radical prostatectomy at our department. Read More

Int J Sport Nutr Exerc Metab 2018 Sep 17;28(5):490-496. Epub 2018 Aug 17.

2 University of Guelph.

Low energy availability (LEA), and subsequent relative energy deficiency in sport, has been observed in endurance, aesthetic, and team sport athletes, with limited data on prevalence in athletes in short-burst activities such as sprinting. We examined prevalence of signs and symptoms of LEA in elite female sprinters at the start of the training season (PRE), and at the end of a 5-month indoor training period (POST). Four of 13 female sprinters (31%) presented at PRE testing with at least one primary (amenorrhea, low bone mineral density, low follicle-stimulating hormone, luteinizing hormone, or estradiol, resting metabolic rate ≤29 kcal/kg fat-free mass, Low Energy Availability in Females Questionnaire score ≥8) and one secondary indicator of LEA (fasting blood glucose <4 mmol/L, free triiodothyronine <3. Read More

Zhonghua Nan Ke Xue 2017 Sep;23(9):808-812

Department of Andrology, Guangzhou First People's Hospital Affiliated to Guangzhou Medical University, Guangzhou, Guangdong 510180, China.

Objective: To investigate the values of serum calculated free testosterone (cFT), testosterone secretion index (TSI), and free testosterone index (FTI) in the diagnosis of ED with androgen deficiency by observing their changes in the patient.

Methods: We conducted this study among 185 men complaining of ED and 35 20－40 years old healthy males presenting at the clinic for premarital medical checkup. We asked them about their medical history, to fill in the International Index of Erectile Function (IIEF-5) Questionnaire, and to complete the nocturnal penile tumescence (NPT) test. Read More

J Inherit Metab Dis 2018 May 2. Epub 2018 May 2.

Metabolic Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.

Background: Transaldolase deficiency (TALDO-D) is a rare autosomal recessive inborn error of the pentose phosphate pathway. Since its first description in 2001, several case reports have been published, but there has been no comprehensive overview of phenotype, genotype, and phenotype-genotype correlation.

Methods: We performed a retrospective questionnaire and literature study of clinical, biochemical, and molecular data of 34 patients from 25 families with proven TALDO-D. Read More

Zhonghua Nan Ke Xue 2017 Mar;23(3):212-216

Department of Urology, The Affiliated Hospital of Jiujiang College, Jiujiang, Jiangxi 332000, China.

Objective: To evaluate the role of the serum testosterone level as an independent predictor of bone metastasis of prostate cancer.

Methods: This study included 165 male patients with prostate cancer confirmed by biopsy. The patients were aged 58－78 (66. Read More

Case Reports Immunol 2018 13;2018:2706751. Epub 2018 Feb 13.

Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, İzmir, Turkey.

Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The management of pregnant patients with C1-INH-HAE is a challenge for the physician. Intravenous plasma-derived nanofiltered C1-INH (pdC1INH) is the only recommended option throughout pregnancy, postpartum, and breastfeeding period. Read More

Arch Iran Med 2018 Feb 1;21(2):56-60. Epub 2018 Feb 1.

Hematology-Oncology and Stem Cell Transplantation Research Center of Tehran University of Medical Sciences, Tehran, Iran.

Background: Beta thalassemia major (BTM) and its treatment by hematopoietic stem cell transplantation (HSCT) may have deleterious effects on the endocrine systems. We assessed endocrine complications of HSCT in pediatric patients for 3 months.

Methods: In 20 (6 female) pediatric major thalassemic patients (mean age of 10. Read More

Endocr Pract 2018 Apr;24(4):375-385

Objective: The decrease in testosterone levels that occurs with aging has become an important clinical issue both due to the growth of the geriatric population and patient interest in testosterone therapy. The decision to assess for testosterone deficiency and the ability to determine whether the benefits exceed the risks require a comprehensive evaluation of the aging patient. This article is part of a series of papers focused on the endocrinology of aging. Read More

J Clin Lipidol 2018 May - Jun;12(3):822-825. Epub 2018 Mar 9.

Guy's, St Thomas' and Lewisham and Greenwich Trust, St. Thomas' Hospital, London, United Kingdom.

We report the case of a 39-year-old West African man in whom high-density lipoprotein cholesterol (HDL-C) was identified as undetectable at <0.08 mmol/L. Total cholesterol in the same sample was 2. Read More

J Sex Med 2018 May 30;15(5):654-661. Epub 2018 Mar 30.

Department of Urology, University of Miami, Miami, FL, USA. Electronic address:

Background: Excess reactive oxygen species and reactive nitrogen species are implicated in male infertility and impaired spermatogenesis.

Aim: To investigate the effect of excess reactive nitrogen species and nitrosative stress on testicular function and the hypothalamic-pituitary-gonadal axis using the S-nitrosoglutathione reductase-null (Gsnor) mouse model.

Methods: Testis size, pup number, and epididymal sperm concentration and motility of Gsnor mice were compared with those of age-matched wild-type (WT) mice. Read More

J Clin Invest 2018 May 26;128(5):1787-1792. Epub 2018 Mar 26.

Institute of Reproductive and Developmental Biology (IRDB), Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.

Spermatogenesis is regulated by the 2 pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This process is considered impossible without the absolute requirement of LH-stimulated testicular testosterone (T) production. The role of FSH remains unclear because men and mice with inactivating FSH receptor (FSHR) mutations are fertile. Read More

JAMA 2018 Apr;319(13):1375-1376

University of Chicago, Chicago, Illinois.

J Med Genet 2018 May 1;55(5):307-315. Epub 2018 Mar 1.

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA.

Background: Nonsense and frameshift mutations in the maternally imprinted, paternally expressed gene located in the Prader-Willi critical region 15q11-15q13, have been reported to cause Schaaf-Yang syndrome (SYS), a genetic disorder that manifests as developmental delay/intellectual disability, hypotonia, feeding difficulties and autism spectrum disorder. Prader-Willi syndrome (PWS) is a genetic disorder characterised by severe infantile hypotonia, hypogonadotrophic hypogonadism, early childhood onset obesity/hyperphagia, developmental delay/intellectual disability and short stature. Scoliosis and growth hormone insufficiency are also prevalent in PWS. Read More

Andrology 2018 05 26;6(3):478-487. Epub 2018 Feb 26.

State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Approximately 40% of middle-aged men exhibit symptoms of late-onset hypogonadism (LOH). However, the mechanism of androgen deficiency is still currently unclear. As shown in our previous studies, the SET protein is expressed in testicular Leydig cells and ovarian granule cells. Read More

J Assist Reprod Genet 2018 May 23;35(5):913-919. Epub 2018 Feb 23.

State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Purpose: The purpose of this study was to investigate a novel mutation in the luteinizing hormone beta-subunit (LHB) gene in one male patient with hypogonadism due to selective luteinizing hormone (LH) deficiency.

Methods: Sanger sequencing of one 28-year-old man born to consanguineous parents was performed. Treatment with human chorionic gonadotropin (hCG) (2000 IU, twice a week) was initiated for 3 months, followed by 5000 IU weekly to date. Read More

BMC Endocr Disord 2018 Feb 7;18(1). Epub 2018 Feb 7.

Department of Medical Genetics, FCM, Unicamp, Rua Tessalia Vieira de Camargo, 126, Campinas, SP, 13083-887, Brazil.

Background: Ultrasensitive assays to measure pre-pubertal gonadotropins levels could help identify patients with Turner syndrome (TS) in mid-childhood, but studies in this field are scarce. The aim of this study was to analyze gonadotropins levels in girls with TS throughout childhood.

Methods: Retrospective longitudinal study conducted with 15 girls with TS diagnosed with < 5 years whose FSH and LH measures were available since then. Read More

BMC Res Notes 2018 Jan 15;11(1):24. Epub 2018 Jan 15.

Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Recent rapid advances in assisted reproductive health technologies enables couples with subfertility to conceive through various intervention. Majority of treatment modalities target the female partner. However it is important to identify and treat male factor subfertility right at the outset. Read More

Nucl Med Rev Cent East Eur 2018 10;21(1):14-19. Epub 2018 Jan 10.

Department of Radiological and Isotopic Diagnosis and Therapy, Medical University of Lodz, 113 Zeromskiego Street, 90-549 Lodz, Poland.

Background: Testosterone deficiency in men is characterized by typical symptoms of hypogonadism and negative influence on the preservation of bone mass. In this study, we analysed the relationship between testosterone concentration and bone metabolism. Moreover, we assessed the impact of one-year compensation of testosterone deficiency in elderly men on bone metabolism and bone mineral density. Read More

Front Biosci (Elite Ed) 2018 03 1;10:334-343. Epub 2018 Mar 1.

Djehuty Biomed Consulting, 106 Rugged Dr., Red Oak, TX 75154.

Testosterone deficiency (TD) is a public health concern, a predictor of metabolic syndrome, and is associated with an increased all-cause and cardiovascular mortality. Testosterone deficiency in men is treated by a variety of methods including injectable testosterone compounds, patches, gels, pellets, and oral preparations. The use of testosterone alone has been linked to various adverse effects including, infertility, testicular atrophy, erythropoiesis, and gynecomastia. Read More

Curr Med Res Opin 2018 May 15;34(5):881-886. Epub 2018 Jan 15.

c Reproductive Medicine, Department of Obstetrics and Gynecology , Hadassah-Hebrew University Medical Center , Ein-Kerem , Jerusalem , Israel.

Objective: To look into current evidence exploring the added value of rLH supplementation to rFSH in GnRH analogues cycles, to identify groups of women that still have no evidence for adjuvant rLH therapy and to discuss ways that may advance research on this topic.

Methods: Eight systematic reviews and meta-analyses exploring the benefit for pregnancy achievement of rLH supplementation, excluding other LH activity preparations, to GnRH analogues cycles in the ART setting were thoroughly evaluated.

Results: Evidence exists to show that rLH supplementation seems to have added value for pregnancy achievement in women with poor ovarian response and in women ≥35 years of age employing the GnRH agonist protocol, while the evidence is still debatable when the GnRH antagonist is administered. Read More

J Endocr Soc 2017 Nov 16;1(11):1362-1371. Epub 2017 Oct 16.

Reproductive Endocrinology Department, Le Kremlin-Bicêtre, F-94275, France.

Context: Hyperprolactinemia-induced hypogonadotropic amenorrhea (hPRL-HA) is a major cause of hypothalamic gonadotrophin-releasing hormone (GnRH) deficiency in women. In hyperprolactinemic mice, we previously demonstrated that hypothalamic kisspeptin (Kp) expression was diminished and that Kp administration restored hypothalamic GnRH release, gonadotropin secretion, and ovarian cyclicity, suggesting that Kp neurons could also play a role in hPRL-HA.

Objective: To study the effect of Kp-10 on the gonadotropic-ovarian axis in women with hPRL-HA. Read More

Clin Endocrinol (Oxf) 2018 Mar 10;88(3):432-441. Epub 2018 Jan 10.

Molecular Reproductive Medicine Unit, Department of Translational Medicine, Lund University, Malmö, Sweden.

Objective: Cancer and its treatment in childhood and young adulthood can cause hypogonadism, leading to increased risk of long-term morbidity and mortality. The aim of this study was to evaluate the risk of presenting with biochemical signs of hypogonadism in testicular cancer survivors (TCS) and male childhood cancer survivors (CCS) in relation to the type of treatment given.

Design: Case-control study. Read More

Mol Genet Metab 2018 01 26;123(1):43-49. Epub 2017 Nov 26.

General Director of Azienda Ospedaliera Ospedali Riuniti Marche Nord, Pesaro, Italy. Electronic address:

Tangier disease is an autosomal recessive disorder caused by mutations in the ABCA1 gene and characterized by the accumulation of cholesteryl ester in various tissues and a near absence of high-density lipoprotein. The subject in this investigation was a 36-year-old Italian man with Tangier disease. He and his wife had come to the In Vitro Fertilization Unit, Pesaro Hospital (Azienda Ospedaliera Ospedali Riuniti Marche Nord) seeking help regarding fertility issues. Read More

J Clin Endocrinol Metab 2018 02;103(2):701-709

Andrology Research Unit, Division of Diabetes, Endocrinology, and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

Context: Clinical sequelae of androgen deficiency share common features with frailty. Evidence supporting the role of androgens in the development of frailty is limited and conflicting.

Objective: To determine associations between male reproductive hormones and prospective changes in frailty status. Read More