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    Chronic hyperandrogenemia and western-style diet beginning at puberty reduces fertility and increases metabolic dysfunction during pregnancy in young adult, female macaques.
    Hum Reprod 2018 Apr;33(4):694-705
    Cardiometabolic Health Division, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA.
    Study Question: What are the impacts of elevated testosterone (T) and an obesogenic western-style diet (WSD), either independently or together, on fertility and metabolic adaptations of pregnancy in primates?

    Summary Answer: Testosterone increases the time to achieve pregnancy, while a WSD reduces overall fertility, and the combination of testosterone and WSD additionally impairs glucose tolerance and causes pregnancy loss.

    What Is Known Already: Both hyperandrogenemia and obesity are hallmarks of polycystic ovary syndrome, which is a leading cause of infertility among women worldwide. Female macaques receiving T and WSD beginning at puberty show increased metabolic, ovarian and uterine dysfunction in the non-pregnant state by 3 years of treatment. Read More

    MRI reveals menstrually-related muscle edema that negatively affects athletic agility in young women.
    PLoS One 2018 24;13(1):e0191022. Epub 2018 Jan 24.
    Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
    Context: About 10% of Japanese female athletes are afflicted by menstrually-related edema, mainly in the lower limbs, and, with few studies on this problem, the effect on performance remains unclear.

    Objective: To quantitatively evaluate fluid retention in the calf in female students over their menstrual cycle using magnetic resonance imaging (MRI) and to determine the relationship of MRI changes and athletic performance.

    Design: The menstrual cycle was divided into 5 phases: menstrual, follicular, ovulatory, early luteal, and late luteal with sampling done in either morning (AM) or afternoon (PM) sessions. Read More

    Chronic hyperandrogenemia in the presence and absence of a western-style diet impairs ovarian and uterine structure/function in young adult rhesus monkeys.
    Hum Reprod 2018 Jan;33(1):128-139
    Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
    Study Question: Does chronic hyperandrogenemia beginning at menarche, in the absence and presence of a western-style diet (WSD), alter ovarian and uterine structure-function in young adult rhesus monkeys?

    Summary Answer: Phenotypic alterations in ovarian and uterine structure/function were induced by exogenous testosterone (T), and compounded in the presence of a WSD (T+WSD).

    What Is Known Already: Hyperandrogenemia is a well-established component of PCOS and is observed in adolescent girls, indicating a potential pubertal onset of disease symptoms. Obesity is often associated with hyperandrogenemia and it is hypothesized that metabolic dysfunction exacerbates PCOS symptoms. Read More

    Effectiveness of Matricaria chamomilla (chamomile) extract on pain control of cyclic mastalgia: a double-blind randomised controlled trial.
    J Obstet Gynaecol 2018 Jan 26;38(1):81-84. Epub 2017 Oct 26.
    d BC of Anesthesiology, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran.
    Breast pain (mastalgia) often precedes menstrual period, which is of mild to moderate severity. This study was performed to determine the effectiveness of chamomile on pain control of cyclic mastalgia. This double-blind randomised controlled clinical trial was conducted on 60 patients with mastalgia referred to the breast clinic of an academic hospital, Mashhad University of Medical Sciences. Read More

    Evidence for disruption of normal circadian cortisol rhythm in women with obesity.
    Gynecol Endocrinol 2018 Apr 25;34(4):336-340. Epub 2017 Oct 25.
    a Department of Obstetrics and Gynecology , University of Colorado School of Medicine , Aurora , CO , USA.
    Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis may play a role in the pathogenesis of comorbidities encountered in obesity, including the relative hypogonadotropic hypogonadism that we and others have observed. We sought to examine serum cortisol profiles throughout the day and evening in a sample of normal weight women and women with obesity. In this cross-sectional study, regularly cycling obese (n = 12) and normal weight (n = 10) women were recruited. Read More

    Premenopausal Reproductive Health Modulates Future Cardiovascular Risk - Comparative Evidence from Monkeys and Women.
    Yale J Biol Med 2017 09 25;90(3):499-507. Epub 2017 Sep 25.
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA.
    Coronary heart disease (CHD) remains the major cause of mortality among postmenopausal women living in industrialized countries. Several lines of evidence suggest that ovarian hormones (especially estrogen) protect the coronary arteries of premenopausal women. However, it is also known that women commonly experience disruptions in cyclic hormonal function during their reproductive years. Read More

    Shared mechanisms of epilepsy, migraine and affective disorders.
    Neurol Sci 2017 May;38(Suppl 1):73-76
    U.O. Neurologia e Stroke Unit, Gallarate Hospital, ASST Valle Olona, Gallarate, Italy.
    Since the nineteenth century several clinical features have been observed in common between migraine and epilepsy (such as episodic attacks, triggering factors, presence of aura, frequent familiarity), but only in recent years researchers have really engaged in finding a common pathogenic mechanism. From studies of disease incidence, we understand how either migraine among patients with epilepsy or epilepsy among migraine patients are more frequent than in the general population. This association may result from a direct causality, by the same environmental risk factors and/or by a common genetic susceptibility. Read More

    Influence of sex, menstrual cycle, and oral contraceptives on cerebrovascular resistance and cardiorespiratory function during Valsalva or standing.
    J Appl Physiol (1985) 2017 Aug 18;123(2):375-386. Epub 2017 May 18.
    School of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada; and
    Women experience orthostatic intolerance more than men, and they experience faintness more in the early follicular [i.e., low-hormone (LH)] than luteal [i. Read More

    Altered fractional amplitude of low frequency fluctuation in premenstrual syndrome: A resting state fMRI study.
    J Affect Disord 2017 08 24;218:41-48. Epub 2017 Apr 24.
    Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi 530023, China. Electronic address:
    Background: Premenstrual syndrome (PMS) is becoming highly prevalent among female and is characterized by emotional, physical and behavior symptoms. Previous evidence suggested functional dysregulation of female brain was expected to be involved in the etiology of PMS. The aim of present study was to evaluate the alterations of spontaneous brain activity in PMS patients based on functional magnetic resonance imaging (fMRI). Read More

    A randomized trial of local endometrial injury during ovulation induction cycles.
    Int J Gynaecol Obstet 2017 Jul 4;138(1):47-52. Epub 2017 May 4.
    Obstetrics and Gynecology Department, Faculty of Medicine, Menoufia University, Shebin-Elkom, Egypt.
    Objective: To investigate the effect of endometrial injury on pregnancy outcomes among infertile women taking clomifene citrate.

    Methods: A prospective randomized trial was undertaken at an Egyptian hospital between January 26, 2015, and July 17, 2016. Eligible women (≥1 year primary/secondary/unexplained infertility, aged 20-35 years, day-2 follicle-stimulating hormone <12 IU/L, normal prolactin/thyroid function/uterine cavity, ≥1 patent tube, male partner with normal semen count and motility, 3 cycles of clomifene citrate without success) were randomly allocated (1:1) using computer-generated numbers into intervention (received endometrial injury on cycle day 15-24) or control groups (sham procedure). Read More

    Blunted Myoglobin and Quadriceps Soreness After Electrical Stimulation During the Luteal Phase or Oral Contraception.
    Res Q Exerc Sport 2017 Jun 7;88(2):193-202. Epub 2017 Apr 7.
    a University of Southern California.
    Purpose: Acute muscle damage after exercise triggers subsequent regeneration, leading to hypertrophy and increased strength after repeated exercise. It has been debated whether acute exercise-induced muscle damage is altered under various premenopausal estrogen conditions. Acute contraction-induced muscle damage was compared during exogenous (oral contraceptive, OC), endogenous (luteal phase, HI), or low (menses, LO) estrogen in healthy young women aged 21 to 30 years old. Read More

    Non-contraceptive oestrogen-containing preparations for controlling symptoms of premenstrual syndrome.
    Cochrane Database Syst Rev 2017 Mar 3;3:CD010503. Epub 2017 Mar 3.
    Academic Department of Obstetrics and Gynaecology, Keele University Medical School, North Staffordshire Hospital, City General Hospital, Newcastle Road, Stoke-on-Trent, Staffordshire, UK, ST4 6QG.
    Background: Premenstrual syndrome (PMS) is a psychological and somatic disorder of unknown aetiology, with symptoms typically including irritability, depression, mood swings, bloating, breast tenderness and sleep disturbances. About 3% to 10% of women who experience these symptoms may also meet criteria for premenstrual dysphoric disorder (PMDD). PMS symptoms recur during the luteal phase of the menstrual cycle and reduce by the end of menstruation. Read More

    HPA axis reactivity to pharmacologic and psychological stressors in euthymic women with histories of postpartum versus major depression.
    Arch Womens Ment Health 2017 06 1;20(3):411-420. Epub 2017 Mar 1.
    Department of Psychiatry, University of North Carolina, 101 Manning Drive, CB#7160, Chapel Hill, NC, 27599-7160, USA.
    It is unclear whether women with a history of postpartum depression (PPD) have residual, abnormal hypothalamic-pituitary-adrenal (HPA) axis reactivity, as has been reported in major depression (MDD). Further unclear is whether the abnormalities in HPA axis reactivity associated with MDD represent a stable, underlying predisposition or a state-dependent phenomenon. This study sought the following: (1) to determine if euthymic postpartum women with a history of depression have an abnormal HPA axis reactivity to pharmacologic and psychological challenges and (2) to compare HPA reactivity in women with histories of PPD versus MDD. Read More

    Progesterone luteal support after ovulation induction and intrauterine insemination: an updated systematic review and meta-analysis.
    Fertil Steril 2017 Apr 24;107(4):924-933.e5. Epub 2017 Feb 24.
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Walter Reed National Military Medical Center, Bethesda, Maryland.
    Objective: To evaluate the effect of progesterone (P) for luteal phase support after ovulation induction (OI) and intrauterine insemination (IUI).

    Design: An updated systematic review and meta-analysis.

    Setting: Not applicable. Read More

    Gonadotropin-releasing hormone analogue as sole luteal support in antagonist-based assisted reproductive technology cycles.
    Fertil Steril 2017 01 27;107(1):130-135.e1. Epub 2016 Oct 27.
    The Fertility Center from A to Z, Assuta Medical Centre, Ramat Aviv, Tel-Aviv, Israel.
    Objective: To evaluate the efficacy of GnRH agonists (GnRH-a) as sole luteal phase support in patients undergoing IVF in antagonist-based cycles compared with standard vaginal P preparations.

    Design: Retrospective cohort.

    Setting: Private fertility clinic. Read More

    GnRH antagonist and letrozole co-treatment in diminished ovarian reserve patients: a proof-of-concept study.
    Reprod Biol 2017 Mar 4;17(1):105-110. Epub 2017 Feb 4.
    The Fertility Clinic, Fertility, Skive Regional Hospital, Faculty of Health, Aarhus University, Resenvej 25, 7800 Skive, Aarhus C, Denmark.
    The current study aimed to investigate the effects of luteal gonadotropin-releasing hormone (GnRH) antagonist pretreatment on the outcomes of diminished ovarian reserve (DOR) patients who were treated using a FSH/letrozole/GnRH antagonist (FLA) protocol. Thus, patients who had luteal GnRH antagonist pretreatment (AFLA) prior to stimulation were compared to patients who had the FLA protocol, only. An electronic database was used to identify patients and stimulation characteristics. Read More

    Blunted cortisol response to psychosocial stress in atopic patients is associated with decrease in salivary alpha-amylase and aldosterone: Focus on sex and menstrual cycle phase.
    Psychoneuroendocrinology 2017 Apr 16;78:31-38. Epub 2017 Jan 16.
    Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia. Electronic address:
    A decreased responsiveness of the hypothalamic-pituitary-adrenocortical axis to stress stimuli in patients with atopy is well documented. The aim of this study was to investigate personality traits, salivary alpha-amylase activity and the aldosterone response to psychosocial stress procedure based on public speech in atopic patients with respect to sex and the menstrual cycle (MC) phase. The study was performed in 106 subjects of both sexes, 53 atopic patients suffering from allergic rhinitis, allergic asthma or atopic dermatitis and 53 age-, sex-, the MC phase- and BMI- matched healthy controls. Read More

    Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss.
    Fertil Steril 2017 Mar 9;107(3):684-690.e2. Epub 2017 Jan 9.
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive and Placental Research Unit, Yale University School of Medicine, New Haven, Connecticut.
    Objective: To assess the effectiveness of luteal start vaginal micronized P in a recurrent pregnancy loss (RPL) cohort.

    Design: Observational cohort study using prospectively collected data.

    Setting: Not applicable. Read More

    Cortisol awakening response is blunted and pain perception is increased during menses in cyclic women.
    Psychoneuroendocrinology 2017 Mar 21;77:158-164. Epub 2016 Dec 21.
    Department of Physiology, Faculty of Medicine, University of Inonu, 44280, Malatya, Turkey. Electronic address:
    Background And Aims: The incidence of menstrual symptoms is reported to be as high as 90% in cyclic women. These symptoms, including anxiety and pain, might be associated with cortisol, as its receptors are widely distributed in the brain areas associated with behavior. Therefore, the current study aimed to assess the cortisol awakening response (CAR) throughout the menstrual cycle and correlate it with pain perception and trait anxiety. Read More

    The influence of coping strategies and behavior on the physiological response to social stress in women: The role of age and menstrual cycle phase.
    Physiol Behav 2017 Mar 15;170:37-46. Epub 2016 Dec 15.
    Laboratory of Social Cognitive Neuroscience, University of Valencia, Valencia, Spain.
    There is information indicating that the variations induced by the menstrual cycle may influence the capacity of young women to respond to stress. The physiological response to stress changes across the stages of the lifespan; however, in spite of the great increase in life expectancy, the way women react after menopause, a period characterized by a dramatic decline in sex hormones, has not been sufficiently studied. The main objective of the study was to examine the capacity to respond to and recover from an acute social stressor in post-menopausal women compared to young women. Read More

    Effect of Low-Dose Aspirin on Midluteal Phase Uterine Artery Blood Flow in Patients With Recurrent Pregnancy Loss.
    J Ultrasound Med 2016 Dec 25;35(12):2583-2587. Epub 2016 Oct 25.
    Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
    Objectives: The purpose of this study was to evaluate differences in uterine artery blood flow parameters and pregnancy outcomes, if any. An investigation was conducted to determine the effects of low-dose aspirin on uterine artery blood flow indices in patients with recurrent pregnancy loss.

    Methods: This observational study included 353 Chinese women with a history of recurrent pregnancy loss and 85 women without a history of recurrent pregnancy loss (control group) from Ren Ji Hospital. Read More

    Does levonorgestrel emergency contraceptive have a post-fertilization effect? A review of its mechanism of action.
    Linacre Q 2016 Feb;83(1):35-51
    Gynecology in the Department of Woman's and Child's Health, University of Padua, Obstetrics and Gynecology Unit, University of Padova, Italy.
    Background: Recent studies have identified that levonorgestrel administered orally in emergency contraception (LNG-EC) is only efficacious when taken before ovulation. However, the drug does not consistently prevent follicular rupture or impair sperm function.

    Objective: The present systematic review is performed to analyze and more precisely define the extent to which pre-fertilization mechanisms of action may explain the drug's efficacy in pregnancy avoidance. Read More

    Elevated circulating micro-ribonucleic acid (miRNA)-200b and miRNA-429 levels in anovulatory women.
    Fertil Steril 2017 01 2;107(1):269-275. Epub 2016 Nov 2.
    The Magda and Richard Hoffman Center for Human Placenta Research, Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; IVF Unit, Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address:
    Objective: To study the role of micro-RNA (miRNA)-200b and miRNA-429 in human ovulation and to measure their expression levels in ovulatory and anovulatory patients.

    Design: Micro-RNA-200b and miRNA-429 expression analysis in human serum and granulosa cells at different phases of the ovulation cycle in normal cycling women and women undergoing assisted reproductive technology cycles.

    Setting: University-affiliated hospital and academic research laboratory. Read More

    Immature oocyte retrieval and in vitro oocyte maturation at different phases of the menstrual cycle in women with cancer who require urgent gonadotoxic treatment.
    Fertil Steril 2017 01 31;107(1):198-204. Epub 2016 Oct 31.
    McGill University Health Centre, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
    Objective: To evaluate the feasibility and the efficacy of in vitro maturation (IVM) when immature oocyte collection was performed in the early follicular, late follicular, or luteal phases in women with cancer who require urgent chemotherapy.

    Design: Retrospective cohort study.

    Setting: University teaching hospital. Read More

    Menstrual cycle-related variation in autonomic nervous system functioning in women in the early menopausal transition with and without insomnia disorder.
    Psychoneuroendocrinology 2017 Jan 14;75:44-51. Epub 2016 Oct 14.
    Center for Health Sciences, SRI International, Menlo Park, CA, 94025, USA; Brain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, 2000, South Africa. Electronic address:
    Insomnia is considered a hyperarousal disorder, in which several psychophysiological domains including the autonomic nervous system (ANS) are over-activated, potentially contributing to increased risk for cardiovascular (CV) disease. Here, we aimed to determine whether insomnia that develops in the context of the transition to menopause (menopausal transition insomnia, MTI) is similarly characterized by autonomic arousal. We also took into account modulation of the ANS by the hormonal changes of the menstrual cycle, a factor that has not previously been considered in studies on insomnia. Read More

    A role for the endocannabinoid system in premature luteal regression and progesterone withdrawal in lipopolysaccharide-induced early pregnancy loss model.
    Mol Hum Reprod 2016 11 28;22(11):800-808. Epub 2016 Jul 28.
    Laboratory of Physiopathology of Pregnancy and Labor, Center for Pharmacological and Botanical Studies, National Research Council, School of Medicine, University of Buenos Aires, Argentina.
    Study Question: What is the role of the endocannabinoid system (eCS) in the alterations of the endocrine system in a murine model of lipopolysaccharide (LPS)-induced miscarriage?

    Summary Answer: In 7-days pregnant wild type, but not cannabinoid receptor type 1 knockout (CB1-KO) mice, LPS increased COX-2 expression and prostaglandin F (PGF) production in the uterus leading to lower expression of prolactin receptor in the ovary and a marked regression of corpora lutea (CL), suggesting that the eCS mediates the deleterious effects of LPS on reproductive events.

    What Is Known Already: Appropriate systemic progesterone levels are critical for a successful pregnancy outcome. Precocious loss of luteal progesterone (P4) secretion leads to miscarriage in rodents. Read More

    Steroid hormone pretreatments in assisted reproductive technology.
    Fertil Steril 2016 Dec 25;106(7):1608-1614. Epub 2016 Oct 25.
    Center of Reproductive Medicine, Hôpital Foch, University Paris-Ouest, Suresnes, France. Electronic address:
    Adequate availability and FSH sensitivity of ovarian antral follicles and coordination of their growth during controlled ovarian hyperstimulation (COH) rank among factors that may determine outcome, particularly in patients presenting ovarian function defects and so-called "poor responders." Growing evidence indicates that both factors are positively influenced by steroid hormone pretreatments. First, data from studies conducted in both animals and in women exposed to virilizing androgen doses indicate that androgen pretreatments may increase follicle responsiveness to FSH and/or the number of growing follicles in the ovary, thereby constituting an interesting perspective in the management of "poor responders. Read More

    The impact of periconceptional maternal stress on fecundability.
    Ann Epidemiol 2016 Oct 20;26(10):710-716.e7. Epub 2016 Aug 20.
    Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY. Electronic address:
    Purpose: To examine the association between periconceptional self-reported stress levels and fecundability in women.

    Methods: Daily stress was reported on a scale from 1 to 4 (lowest to highest) among 400 women who completed daily diaries including data on lifestyle and behavioral factors, menstrual characteristics, contraceptive use, and intercourse for up to 20 cycles or until pregnancy. Discrete survival analysis was used to estimate the associations between self-reported stress during specific windows of the menstrual cycle and fecundability (cycles at risk until pregnancy), adjusting for potential confounders. Read More

    Embryo Mortality Around the Period of Maintenance of the Corpus Luteum Causes Alterations to the Ovarian Function of Lactating Dairy Cows.
    Biol Reprod 2016 11 5;95(5):112. Epub 2016 Oct 5.
    Department of Animal Science, Cornell University, Ithaca, New York
    Objectives were to identify cows with embryo mortality (EM) around the period of corpus luteum maintenance by interferon tau (IFNT) and to characterize ovarian function in cows that underwent EM. Lactating Holstein cows received artificial insemination (AI) (Day = 0) with semen or extender only. From Day 14 to 42 transrectal ultrasonography was performed daily to monitor ovarian dynamics and uterine contents whereas blood was collected every 48 h to determine ISG15 and MX2 mRNA abundance in blood mononuclear cells (Day 14 to 22 only) and determination of hormone concentrations. Read More

    Body condition and stage of seasonal anestrus interact to determine the ovulatory response after male biostimulation in anovulatory Criollo × Nubian goats.
    Anim Sci J 2017 Jun 17;88(6):841-846. Epub 2016 Oct 17.
    CENID Microbiología, INIFAP, Mexico.
    The effect of goat nutritional condition on the response to biostimulation with sexually active males during different stages of anestrus was determined. Fifty-eight Criollo × Nubian females on high and low body mass index (BMI) diets were used. Each BMI group was divided into two for biostimulation with sexually active males during May (mid-anestrus) or July (transition period). Read More

    Change in women's eating habits during the menstrual cycle.
    Ann Endocrinol (Paris) 2017 Feb 12;78(1):33-37. Epub 2016 Sep 12.
    Service d'endocrinologie et des maladies métaboliques, Institut national de nutrition et des technologies alimentaires, 11, street Jebel Lakhdhar, 1007, Bab Saadoun, Tunis, Tunisia.
    Objectives: During the menstrual cycle, the influence of hormonal variations on dietary habits in women has been suggested by several studies. In this context, our work aimed to assess the spontaneous food intake and the anthropometric parameters of women at different periods of their menstrual cycles.

    Methods: This prospective study included 30 healthy women with regular periods (28 to 30 days), aged between 18 and 45. Read More

    Women with Premenstrual Dysphoria Lack the Seemingly Normal Premenstrual Right-Sided Relative Dominance of 5-HTP-Derived Serotonergic Activity in the Dorsolateral Prefrontal Cortices - A Possible Cause of Disabling Mood Symptoms.
    PLoS One 2016 12;11(9):e0159538. Epub 2016 Sep 12.
    Department of Women's and Children's Health, Obstetrics and Gynaecology, Uppsala University Hospital, Uppsala, Sweden.
    Study Objective: To investigate potential quantitative and qualitative differences in brain serotonergic activity between women with Premenstrual Dysphoria (PMD) and asymptomatic controls.

    Background: Serotonin-augmenting drugs alleviate premenstrual mood symptoms in the majority of women with PMD while serotonin-depleting diets worsen PMD symptoms, both indicating intrinsic differences in brain serotonergic activity in women with PMD compared to asymptomatic women.

    Methods: Positron-emission tomography with the immediate precursor of serotonin, 5-hydroxytryptophan (5-HTP), radiolabelled by 11C in the beta-3 position, was performed in the follicular and luteal phases for 12 women with PMD and 8 control women. Read More

    Impact of luteal phase support with vaginal progesterone on the clinical pregnancy rate in intrauterine insemination cycles stimulated with gonadotropins: a randomized multicenter study.
    Fertil Steril 2016 Nov 23;106(6):1490-1495. Epub 2016 Aug 23.
    LUFC-Department of Obstetrics and Gynaecology, University Hospitals Leuven; Department of Development and Regeneration, Leuven, Belgium. Electronic address:
    Objective: To evaluate the effect of luteal phase support (LPS) in intrauterine insemination (IUI) cycles stimulated with gonadotropins.

    Design: Randomized multicenter trial.

    Setting: Academic tertiary care centers and affiliated secondary care centers. Read More

    The role of emotion regulation in the experience of menstrual symptoms and perceived control over anxiety-related events across the menstrual cycle.
    Arch Womens Ment Health 2016 12 25;19(6):1109-1117. Epub 2016 Aug 25.
    Rutgers, The State University of New Jersey, New Brunsick, USA.
    Hormonal variation throughout the menstrual cycle is posited to impact various physical and mental health symptoms; however, this is not observed in all women and mechanisms are not well understood. Difficulty in emotion regulation may elucidate differences that women experience in physical and mental health functioning between menstrual phases. We examined the moderating role of difficulty in emotion regulation in the relation between menstrual phase and menstrual symptom severity and perceived control over anxiety-related events, in healthy, regularly menstruating women. Read More

    Sympathetic neural and cardiovascular responses during static handgrip exercise in women with a history of hypertensive pregnancy.
    Clin Auton Res 2016 Dec 9;26(6):395-405. Epub 2016 Aug 9.
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, 7232 Greenville Ave, Dallas, TX, 75231, USA.
    Purpose: Women with a history of hypertensive pregnancy are at greater risk for future cardiovascular events; however, the mechanisms for this increased risk are unknown. Evidence suggests that an exercise stimulus unmasks latent hypertensive tendencies, identifying individuals at the greatest risk for developing cardiovascular disease. The current study examined the hypothesis that women with a hypertensive pregnancy history exhibit an augmented exercise pressor response. Read More

    Association of Premenstrual Syndrome with Blood Pressure in Young Adult Women.
    J Womens Health (Larchmt) 2016 Nov 15;25(11):1122-1128. Epub 2016 Jul 15.
    3 Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts , Amherst, Massachusetts.
    Objective: The prevalence of hypertension in premenopausal women is increasing. There is substantial need for novel strategies to identify women who would benefit from increased screening and early interventions. Several mechanisms likely contributing to premenstrual syndrome (PMS) are also involved in hypertension, including renin-angiotensin-aldosterone system dysfunction and micronutrient deficiencies. Read More

    Borderline and cluster C personality disorders manifest distinct physiological responses to psychosocial stress.
    Psychoneuroendocrinology 2016 Oct 22;72:131-8. Epub 2016 Jun 22.
    Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address:
    Background: Maladaptive emotional control is a defining feature of personality disorders. Yet little is known about the underlying physiological dynamics of emotional reactivity to psychosocial stress across distinct personality disorders. The current study compared subjective emotional responses with autonomic nervous system and HPA axis physiological responses to psychosocial stress in women with cluster C personality disorder (CPD) and borderline personality disorder (BPD). Read More

    Phenotypic and clinical aspects of Mayer-Rokitansky-Küster-Hauser syndrome in a Chinese population: an analysis of 594 patients.
    Fertil Steril 2016 Oct 24;106(5):1190-1194. Epub 2016 Jun 24.
    Department of Obstetrics and Gynecology, Affiliated Luohu Hospital of Shenzhen University, Shenzhen, Guangdong, People's Republic of China. Electronic address:
    Objective: To analyze the phenotypic and clinical aspects of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome.

    Design: Cross-sectional study.

    Setting: University hospital. Read More

    Clinical Significance and Characteristic Clinical Differences of Cytolytic Vaginosis in Recurrent Vulvovaginitis.
    Gynecol Obstet Invest 2017 15;82(2):137-143. Epub 2016 Jun 15.
    Department of Laboratory Medicine, Tianjin Central Obstetrics and Gynecology Hospital, Tianjin, China.
    Aim: The study aimed to evaluate whether cytolytic vaginosis (CV) has important clinical implications for recurrent vulvovaginitis and to identify clinical differences between CV and vulvovaginal candidosis (VVC).

    Methods: Medical histories, physical examinations and laboratory findings were used to diagnose and assess the prevalence rates of various vulvovaginal infections among 536 women with recurrent vulvovaginitis. Chi-square and Fisher exact tests were used to compare age, menstrual cycle phase at episode onset, symptoms/signs of infection and discharge characteristics between CV and VVC with single infection. Read More

    Prepulse inhibition deficits in women with PTSD.
    Psychophysiology 2016 Sep 30;53(9):1377-85. Epub 2016 May 30.
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Prepulse inhibition (PPI) is an automatic and preattentive process, whereby a weak stimulus attenuates responding to a sudden and intense startle stimulus. PPI is a measure of sensorimotor filtering, which is conceptualized as a mechanism that facilitates processing of an initial stimulus and is protective from interruption by a later response. Impaired PPI has been found in (a) healthy women during the luteal phase of the menstrual cycle, and (b) individuals with types of psychopathology characterized by difficulty suppressing and filtering sensory, motor, or cognitive information. Read More

    Random-start controlled ovarian stimulation for emergency fertility preservation in a patient with myelodysplastic syndrome: a case report.
    Braz J Med Biol Res 2016 10;49(6):e5227. Epub 2016 May 10.
    Reproductive Medical Center, Peking University People's Hospital, Beijing, China.
    This study reports a case of a gonadotropin-releasing hormone agonist trigger in a young female with myelodysplastic syndrome (MDS) who underwent fertility preservation using random-start controlled ovarian stimulation. This method involves the stimulation of the ovary regardless of a patient's menstrual-cycle phase. A review of the related literature is also provided. Read More

    Endocrine dysfunction and recurrent spontaneous abortion: An overview.
    Int J Appl Basic Med Res 2016 Apr-Jun;6(2):79-83
    Department of Biochemistry, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
    Miscarriage is the spontaneous loss of a fetus before it is viable, occurring at a rate of 15-20%. Recurrent spontaneous abortion (RSA) or habitual miscarriage is defined as repeated occurrence of 3 or more miscarriages before 20(th) week of gestation accounting for the most common complication of early pregnancy in humans. Various etiological factors responsible for recurrent miscarriage are anatomical, genetical, endocrinological, immunological, and infectious. Read More

    Intranasal gonadotropin-releasing hormone agonist (GnRHa) for luteal-phase support following GnRHa triggering, a novel approach to avoid ovarian hyperstimulation syndrome in high responders.
    Fertil Steril 2016 08 22;106(2):330-3. Epub 2016 Apr 22.
    Fertility Center From A to Z, Ramat Aviv, Israel; IVF Unit, Assuta Medical Center, Rishon Lezion, Israel.
    Objective: To study whether intranasal GnRH agonist (GnRHa) can be effectively used for luteal support in high-responder patients undergoing fresh-embryo transfer after ovulation induction with the use of GnRHa.

    Design: Retrospective cohort study.

    Setting: Private fertility clinic. Read More

    Flexibility in starting ovarian stimulation at different phases of the menstrual cycle for treatment of infertile women with the use of in vitro fertilization or intracytoplasmic sperm injection.
    Fertil Steril 2016 Aug 22;106(2):334-341.e1. Epub 2016 Apr 22.
    Department of Assisted Rreproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China. Electronic address:
    Objective: To investigate flexibility in starting controlled ovarian stimulation at any phase of the menstrual cycle in infertile women undergoing treatment with assisted reproduction.

    Design: Retrospective cohort study.

    Setting: Academic tertiary-care medical center. Read More

    Luteal versus follicular phase surgical oophorectomy plus tamoxifen in premenopausal women with metastatic hormone receptor-positive breast cancer.
    Eur J Cancer 2016 06 20;60:107-16. Epub 2016 Apr 20.
    The Ohio State University Center for Biostatistics, Columbus, Ohio, USA. Electronic address:
    Purpose: In premenopausal women with metastatic hormone receptor-positive breast cancer, hormonal therapy is the first-line therapy. Gonadotropin-releasing hormone analogue + tamoxifen therapies have been found to be more effective. The pattern of recurrence risk over time after primary surgery suggests that peri-operative factors impact recurrence. Read More

    Does the risk of metabolic disorders increase among women with polycystic ovary morphology? A population-based study.
    Hum Reprod 2016 06 12;31(6):1339-46. Epub 2016 Apr 12.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 24 Parvaneh, Yaman Street, Velenjak, PO Box 19395-4763, Tehran, Iran.
    Study Question: Is polycystic ovary morphology (PCOM) associated with metabolic syndrome (MS), insulin resistance (IR) and dyslipidemia?

    Summary Answer: No associations between PCOM and metabolic disorders were found.

    What Is Known Already: Polycystic ovary morphology has a prevalence of 21-63% in healthy women of reproductive age. Results of studies focusing on metabolic abnormalities among females with PCOM, are insufficient and controversial. Read More

    Timing of breast cancer surgery, menstrual phase, and prognosis: Systematic review and meta-analysis.
    Crit Rev Oncol Hematol 2016 Jun 19;102:1-14. Epub 2016 Feb 19.
    Department of Psychology, San Diego State University, United States.
    Background: For over 25 years, there has been a debate revolving around the timing of breast cancer surgery, menstrual cycle, and prognosis.

    Methods: This systematic review synthesizes and evaluates the body of evidence in an effort to inform evidence-based practice. A keyword and reference search was performed in PubMed and Web of Science to identify human studies that met the inclusion criteria. Read More

    Women with premenstrual dysphoric disorder have altered sensitivity to allopregnanolone over the menstrual cycle compared to controls-a pilot study.
    Psychopharmacology (Berl) 2016 06 10;233(11):2109-17. Epub 2016 Mar 10.
    Department of Clinical Science, Umeå University, 901 85, Umeå, Sweden.
    Rationale: In premenstrual dysphoric disorder (PMDD), a condition that afflicts 3-8 % of women in fertile ages, the cyclic recurrence of debilitating mood symptoms is restricted to the luteal phase of the menstrual cycle. The progesterone metabolite allopregnanolone is produced by the corpus luteum, and circulating levels are reflected in the brain. Allopregnanolone is a modulator of the GABAA receptor, enhancing the effect of γ-aminobutyric acid (GABA). Read More

    Controlled Ovarian Stimulation Using Medroxyprogesterone Acetate and hMG in Patients With Polycystic Ovary Syndrome Treated for IVF: A Double-Blind Randomized Crossover Clinical Trial.
    Medicine (Baltimore) 2016 Mar;95(9):e2939
    From the Department of Assisted Reproduction, Shanghai Ninth People's Hospital, JiaoTong University School of Medicine, Shanghai, China.
    Ovarian hyperstimulation syndrome (OHSS) during ovarian stimulation is a current challenge for patients with polycystic ovarian syndrome (PCOS). Our previous studies indicated that progestin can prevent premature luteinizing hormone (LH) surge or moderate/severe OHSS in the general subfertile population, both in the follicular-phase and luteal-phase ovarian stimulation but it is unclear if this is true for patients with PCOS. The aim of the article was to analyze cycle characteristics and endocrinological profiles using human menopausal gonadotropin (hMG) in combination with medroxyprogesterone acetate (MPA) for PCOS patients who are undergoing IVF/intracytoplasmic sperm injection (ICSI) treatments and investigate the subsequently pregnancy outcomes of frozen embryo transfer (FET). Read More

    [Glycemic changes during menstrual cycles in women with type 1 diabetes].
    Med Clin (Barc) 2016 Apr 18;146(7):287-91. Epub 2016 Feb 18.
    Unidad de Diabetes, Departamento de Endocrinología, Hospital Universitario La Paz, Madrid, España.
    Background And Objective: To determine frequency of women with type 1 diabetes showing menstrual cyclic changes in glycemia, analyze their clinical characteristics, and assess the pattern of glycemic changes.

    Patients And Methods: We analyzed glucose meter readings along 168 menstrual cycles of 26 women with type 1 diabetes. We evaluated mean glucose, mean glucose standard deviation, mean fasting glucose, percentage of glucose readings>7. Read More

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