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Med Sci Monit 2022 Jun 24;28:e936727. Epub 2022 Jun 24.

Department of Obstetrics and Gynecology, Biruni University School of Medicine, Istanbul, Turkey.

BACKGROUND Abnormal uterine bleeding (AUB) lowers the quality of life of women. This study attempted to determine which treatment protocol of medroxyprogesterone acetate (MPA), 15 vs 10 day-administration in a luteal phase, provides better outcomes in women with ovulatory dysfunction-related AUB (AUB-O). MATERIAL AND METHODS The study included a total of 52 patients with AUB-O: Women in Group A were given MPA between days 11 and 25 of the menstrual cycle (15-day protocol), whereas women in Group B were given MPA between days 16 and 25 (10-day protocol). Read More

Front Endocrinol (Lausanne) 2022 19;13:753416. Epub 2022 May 19.

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Recurrent implantation failure (RIF) is a disease associated with endometrial receptivity dysfunction. Retinoic acid receptor alpha (RARα) is an important protein in many biological processes, such as differentiation and development. However, the exact underlying mechanism whereby RARα affects RIF remains unknown. Read More

Gynecol Endocrinol 2022 May 30:1-4. Epub 2022 May 30.

Department of Obstetrics and Gynecology, Policlinico Casilino Hospital, Rome, Italy.

The number of pregnancies obtained through fertilization (IVF) techniques are increasing, and only few studies have investigated hemodynamic variations in women undergoing IVF techniques. The aim of this study was to evaluate the hemodynamic parameters in women undergoing IVF, to assess a possible correlation between hemodynamics and embryo implantation. 45 normotensive non-obese women, age ≤ 43 years, with idiopathic or tubal infertility, referred to the Reproductive Physiopathology and Andrology Unit, Sandro Pertini Hospital, Rome, during the period 2020/2021, underwent IVF techniques. Read More

Animals (Basel) 2022 Feb 17;12(4). Epub 2022 Feb 17.

Faculty of Veterinary Medicine, Department of Clinical Sciences, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.

While the prevalence of asthma is higher in boys than in girls during childhood, this tendency reverses at puberty, suggesting an effect of sex hormones on the disease pathophysiology. Fluctuations of asthma severity concurring with the estrus cycle are reported in women, but this phenomenon has never been investigated in mares to date. The objective of this exploratory study was to determine whether the estrus cycle modulates airway obstruction in severe equine asthma (SEA). Read More

Front Endocrinol (Lausanne) 2021 3;12:564344. Epub 2022 Jan 3.

Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Oocyte retrieval is a routine procedure during the application of assisted reproduction technology. However, technical difficulties experienced during oocyte retrieval and the subsequent unsatisfactory number of oocytes obtained are rarely reported. The current study included 10,624 oocyte retrieval cycles from April 2015 to June 2018, and patients were followed up until February 2019. Read More

Medicine (Baltimore) 2021 Sep;100(37):e27194

Women's Hospital, School of Medicine, Zhejiang University, Hangzhou City, Zhejiang Province, China.

Abstract: To compare the patients' outcomes of Asherman syndrome who underwent uterine adhesiolysis in luteal phase or follicular phase.A retrospective cohort study.A tertiary hospital in China. Read More

Front Physiol 2021 6;12:737878. Epub 2021 Sep 6.

Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Objective: To explore the therapeutic efficacy of intrauterine perfusion of cyclosporin A (CsA) in intractable recurrent spontaneous abortion (RSA) patients with endometrial alloimmune dysfunction.

Methods: This is a randomized controlled trial (RCT) of patients with intractable RSA with endometrial alloimmune disorders. A total of 201 women were enrolled, all of whom had at least 3 serial abortions and endometrial alloimmune dysfunction. Read More

Women Health 2021 09;61(8):819-827

Department of Exercise Physiology, Nippon Sport Science University, Tokyo, Japan.

The aim of this study was to investigate the effects of weight management on menstrual status in female athletes. A total of 225 collegiate athletes and 27 para-athletes who belonged to teams affiliated with the Japanese Paralympic Committee were included in this cross-sectional survey. A self-reported questionnaire (containing information on the demographic characteristics, medical history, lifestyle habits, weight management, menstruation status, physical symptoms related to menstrual cycle, and the influence of physical symptoms experienced during the luteal phase of menstruation during training or competition. Read More

Gynecol Endocrinol 2021 Oct 19;37(10):945-949. Epub 2021 Aug 19.

Programa de Pós-Graduação em Ciências da Saúde: Ginecologia e Obstetrícia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.

Objective: Examine the relationship between Premenstrual Syndrome (PMS) and sleep in different menstrual cycle phases.

Methods: Case-control survey conducted at the Primary Care Service and Clinical Research Center at Hospital de Clínicas de Porto Alegre with women aged between 18 and 45 years old. Women filled the Brazilian version of the Premenstrual Symptoms Screen Tool (PSST) for the screening of PMS; participants with positive screening completed the Daily Record of Severity of Problems (DRSP) to confirm PMS diagnosis. Read More

Aging (Albany NY) 2021 08 4;13(15):19529-19541. Epub 2021 Aug 4.

College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.

Aims: Premenstrual dysphoric disorder (PMDD) is a psychiatric condition that is associated with the menstrual cycle. Elucidation of the neural regulation mechanisms of brain reactivity to emotional stimuli among women with PMDD may inform PMDD treatment.

Methods: Eighty-six women (42 PMDD, 44 healthy controls) were allocated into two groups (anger-induced group: 23 PMDD vs. Read More

Geburtshilfe Frauenheilkd 2021 Jul 23;81(7):769-779. Epub 2021 Apr 23.

Medical University Innsbruck, Department of Gynaecological Endocrinology and Reproductive Medicine, Innsbruck, Austria.

While roughly 30% of all women experience a spontaneous miscarriage in their lifetime, the incidence of recurrent (habitual) spontaneous miscarriage is 1 - 3% depending on the employed definition. The established risk factors include endocrine, anatomical, infection-related, genetic, haemostasis-related and immunological factors. Diagnosis is made more difficult by the sometimes diverging recommendations of the respective international specialist societies. Read More

Eur J Appl Physiol 2021 Nov 8;121(11):2993-3003. Epub 2021 Jul 8.

Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.

Purpose: Variations in substrate metabolism have been identified in women during continuous steady-state aerobic exercise performed at the same relative intensity throughout discrete phases of the menstrual cycle, although some evidence exists that this is abolished when carbohydrate is ingested. This investigation examined the effects of a supraphysiologic exogenous glucose infusion protocol, administered during two phases of the menstrual cycle (follicular and luteal) in eumenorrheic women to identify differences between metabolic, hormonal and substrate oxidative responses.

Methods: During the experimental conditions, blood glucose was infused intravenously at rates to "clamp" blood glucose at 10 mM in seven healthy females (age 20 ± 1 y, mass 55. Read More

BMC Pregnancy Childbirth 2021 Jul 7;21(1):495. Epub 2021 Jul 7.

Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

Background: Restorative reproductive medicine (RRM) seeks to identify and correct underlying causes and factors contributing to infertility and reproductive dysfunction. Many components of RRM are highly suitable for primary care practice. We studied the outcomes amongst couples who received restorative reproductive medicine treatment for infertility in a primary care setting. Read More

EBioMedicine 2021 Jul 2;69:103434. Epub 2021 Jul 2.

MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.

Background: The symptom of heavy menstrual bleeding (HMB) diminishes quality-of-life for many mid-age women and imposes substantial societal burden. We investigated our hypothesis that HMB reflects impaired endometrial vasoconstriction due to endometrial glucocorticoid deficiency. Does reversing this deficiency, by short-term luteal-phase treatment with exogenous glucocorticoid (dexamethasone), ameliorate HMB?

Methods: In our Bayesian response-adaptive parallel-group placebo-controlled randomised trial, five pre-planned interim analyses used primary outcome data to adjust randomisation probabilities to favour doses providing most dose-response information. Read More

Front Endocrinol (Lausanne) 2021 17;12:578783. Epub 2021 May 17.

Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: To investigate the factors that influence luteal phase short-acting gonadotropin-releasing hormone agonist (GnRH-a) long protocol and GnRH-antagonist (GnRH-ant) protocol on pregnancy outcome and quantify the influence. About the statistical analysis, it is not correct for the number of gravidities.

Methods: Infertile patients (n = 4,631) with fresh - fertilization/intracytoplasmic sperm injection (IVF/ICSI) and embryo transfer were divided into GnRH-a long protocol (n =3,104) and GnRH-ant (n =1,527) protocol groups and subgroups G1 (EMT ≤7mm), G2 (7 mm 10 mm) according to EMT on the trigger day. Read More

Int J Environ Res Public Health 2021 04 28;18(9). Epub 2021 Apr 28.

Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.

Background: Premenstrual syndrome (PMS) is a common disorder affecting the quality of life of women of reproductive age. In a previous study, sex hormone imbalances and alterations in autonomic function were present in PMS, with parasympathetic dysfunction and sympathetic overactivity during the late luteal phase. Palmar hyperhidrosis (PH) presents with oversweating, heat and emotional stimulation, sympathetic hyperactivity and parasympathetic hypofunction. Read More

Fertil Steril 2021 06 4;115(6):1416-1423. Epub 2021 Apr 4.

American Society for Reproductive Medicine, Birmingham, Alabama.

Luteal phase deficiency (LPD) is a clinical diagnosis associated with an abnormal luteal phase length of ≤10 days. Potential etiologies of LPD include inadequate progesterone duration, inadequate progesterone levels, or endometrial progesterone resistance. LPD has not only been described in association with medical conditions but also in fertile, normally menstruating women. Read More

Int J Environ Res Public Health 2021 03 4;18(5). Epub 2021 Mar 4.

Department of Gerontology and Geriatric Nursing, Faculty of Health Sciences, Medical University of Silesia, 40-635 Katowice, Poland.

Sexual dysfunction is more common in women with diabetes than in women without diabetes. The aim of the study was to determine sexual function and the level of the quality of sex life in premenopausal women with controlled, uncomplicated type 1 and type 2 diabetes taking into account the stages of the menstrual cycle and mood level. The study included 163 women with type 1 and type 2 diabetes and 115 controls without diabetes. Read More

Pharmaceuticals (Basel) 2021 Mar 7;14(3). Epub 2021 Mar 7.

Obstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant'Anna Hospital, University of Torino, 10042 Turin, Italy.

The segmentation of the in vitro fertilization (IVF) cycle, consisting of the freezing of all embryos and the postponement of embryo transfer (ET), has become popular in recent years, with the main purpose of preventing ovarian hyperstimulation syndrome (OHSS) in patients with high response to controlled ovarian stimulation (COS). Indeed cycle segmentation (CS), especially when coupled to a GnRH-agonist trigger, was shown to reduce the incidence of OHSS in high-risk patients. However, CS increases the economic costs and the work amount for IVF laboratories. Read More

J Foot Ankle Res 2021 Mar 24;14(1):21. Epub 2021 Mar 24.

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, 950-3198, Shimami-cho 1398, Kita-Ku,, Niigata, Japan.

Background: The purpose of the present study was to examine the relationship between ankle joint laxity and general joint laxity (GJL) in relation to the menstrual cycle, which was divided into four phases based on basal body temperature and ovulation, assessed using an ovulation kit.

Methods: Participants were 14 female college students (21-22 years) with normal menstrual cycles (cis gender). Anterior drawer stress to a magnitude of 120 N was applied for all participants. Read More

Niger J Clin Pract 2021 Mar;24(3):308-312

Department of Chest Diseases, Medical Faculty, Tokat Gaziosmanpasa University, Tokat, Turkey.

Background: Primary dysmenorrhea (PD) is characterized by symptoms including sweating, headache, nausea, vomiting, diarrhea, tremulousness, usually begins adolescence, those can be associated with autonomic dysfunction affecting pulmonary functions.

Aim: The aim of the present study is to investigate the impacts of PD on pulmonary function tests.

Subjects And Methods: A prospective cross-sectional design was selected. Read More

J Turk Ger Gynecol Assoc 2021 05 5;22(2):139-148. Epub 2021 Mar 5.

Department of Obstetrics and Gynecology, University of Health Sciences Turkey, Etlik Zübeyde Hanım Women’s Health and Research Center, Ankara, Turkey

Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are characterized by somatic and psychologic symptoms that arise at the luteal phase of the menstrual cycle and subside with menstruation. For definitive diagnosis prospectively self-reported symptoms should demonstrate a cyclic pattern and other psychological pathologies and thyroid dysfunction, that may present with similar symptoms, should be excluded. Both entities affect millions of women at reproductive age as the prevalence of PMS is given as 10-98% while PMDD affects 2-8%. Read More

Appl Physiol Nutr Metab 2021 Oct 2;46(10):1179-1188. Epub 2021 Mar 2.

Sports Performance Laboratory, Sports Medicine Program, University of California Davis, Sacramento, CA, USA.

Low energy availability (EA) suppresses many physiological processes, including ovarian function in female athletes. Low EA could also predispose athletes to develop a state of overreaching. This study compared the changes in ad libitum energy intake (EI), exercise energy expenditure (ExEE), and EA among runners completing a training overload (TO) phase. Read More

Psychopharmacology (Berl) 2021 Jun 23;238(6):1541-1552. Epub 2021 Feb 23.

National Center for PTSD Women's Health Sciences Division at VA Boston Healthcare System, Boston, MA, 02130, USA.

Rationale: Aberrations in the stress response are associated with posttraumatic stress disorder (PTSD) symptom development, maintenance, and severity. Gamma-aminobutyric acid (GABA), the brain's primary inhibitory neurotransmitter, may play a key role in stress recovery.

Objectives: In this preliminary study, we examined whether plasma GABA levels differed between women with PTSD and trauma-exposed healthy controls. Read More

Medicine (Baltimore) 2021 Feb;100(5):e23798

Department of Rehabilitation, Shanghai Xuhui Central Hospital, Shanghai, China.

Background: There are scanty data to apply radial extracorporeal shock wave therapy (rESWT) on the acupuncture points in the lower abdomen to reduce the menstrual pain. This trial aimed to test the rESWT safety and efficacy for treating primary dysmenorrhea (PD).

Methods: Forty-four young-women with PD were randomly assigned to one of the three groups: to receive rESWT on the acupuncture points during the follicular phase (Group A, n = 15) or during the luteal phase (Group B, n = 14), or to apply heat patch to the acupuncture points during the follicular phase as the control (Group C, n = 15) over three menstrual cycles. Read More

Reprod Biomed Online 2021 Apr 27;42(4):835-841. Epub 2020 Dec 27.

Department di Translational Medical Science, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Research Question: Wilson's disease (WD) is a disorder of copper metabolism that can cause hormonal alterations. The impact of WD and its therapies on fertility is not well defined. The aim of this study was to evaluate ovarian reserve and sperm parameters in long-term treated WD patients with hepatic onset. Read More

J Vasc Interv Radiol 2021 03 16;32(3):332-338. Epub 2021 Jan 16.

Department of Radiology, Saiseikai Shiga Hospital, Ohashi 2-4-1, Ritto, Shiga 520-3046, Japan.

Purpose: To investigate differences in outcomes of uterine artery embolization (UAE) for leiomyoma when performed during different phases of the menstrual cycle.

Materials And Methods: In this single-institution retrospective analysis, 111 premenopausal patients (median [range] age, 44 [33-52] years) undergoing UAE for symptomatic leiomyoma between June 2014 and February 2020 were included. Twenty-one patients underwent UAE in the menstrual phase (the early follicular phase), 27 in the late follicular phase, and 63 in the luteal phase. Read More

Tohoku J Exp Med 2021 01;253(1):51-60

Department of Cardiovascular Medicine, Dokkyo Medical University School of Medicine.

The cold-sensitivity constitution (CSC), termed "Hiesho" in Japanese, is a woman-specific cold sense of peripheral sites. The etiology of and criteria for CSC are not yet well established. We defined CSC as temperature gradient > 6˚C between body surface and core, and investigated the autonomic nervous activity by measuring heart rate variability and the vascular endothelial function by determining reactive hyperemia index (RHI) in 43 healthy premenopausal women, aged 18-47 years. Read More

J Clin Endocrinol Metab 2021 01;106(2):e721-e738

Gynecology and Physiopathology of Human Reproduction Unit, Department of Medical and Surgical Sciences, University of Bologna, S. Orsola-Malpighi Hospital of Bologna, Bologna, Italy.

Purpose: Exogenous gonadotrophins administration during in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles could significantly alter the endogenous follicular regulation system and could influence oocyte quality. The analysis of the follicular fluid (FF) cytokine and hormone profiles in physiological natural cycles is crucial to appreciate the role of FF milieu on follicle development. So far, the FF cytokine profile has been analyzed only in controlled ovarian stimulation cycles and in modified natural cycles. Read More

Neuropsychologia 2020 12 5;149:107669. Epub 2020 Nov 5.

Department of Psychology, Nanjing University, Nanjing, 210023, China. Electronic address:

Background: Most studies on the mechanism behind premenstrual syndrome (PMS) have focused on negative emotional overreaction, but little evidence exists regarding the weakening of positive emotions. Given the close relationship between positive emotions and reward processing, the aim of this study is to investigate the dysfunction of reward processing in women with PMS.

Method: Seventeen women with PMS and seventeen healthy women were scanned during a card guessing task in the late luteal phase. Read More