18,713 results match your criteria Luteal Phase Dysfunction


Impairment of the antifibrotic prostaglandin E pathway may influence neutrophil extracellular traps-induced fibrosis in the mare endometrium.

Domest Anim Endocrinol 2018 Nov 3;67:1-10. Epub 2018 Nov 3.

Department of Morphology and Function, CIISA- Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

Prostaglandin E (PGE) has contradictory effects in many organs. It may have proinflammatory, anti-inflammatory, or anti-fibrotic roles, depending on the type of receptors to which it binds. By signaling through its receptors EP2 and EP4, PGE mediates anti-inflammatory and anti-fibrotic actions. Read More

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November 2018
2 Reads

Luteal granulosa cells from natural cycles are more capable of maintaining their viability, steroidogenic activity and LH receptor expression than those of stimulated IVF cycles.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

Graduate School of Health Sciences, Koc University, Davutpasa, Topkapi, Istanbul, Turkey.

Study Question: Are there any differences in the molecular characteristics of the luteal granulosa cells (GC) obtained from stimulated versus non-stimulated (natural) IVF cycles that may help explain the defective luteal phase in the former?

Summary Answer: Luteal GC of stimulated IVF cycles, particularly those of agonist-triggered antagonist cycles, are less viable ex vivo, express LH receptor and anti-apoptotic genes at lower levels, undergo apoptosis earlier and fail to maintain their estradiol (E2) and progesterone (P4) production in comparison to natural cycle GC.

What Is Known Already: Luteal function is defective in stimulated IVF cycles, which necessitates P4 and/or hCG administration (known as luteal phase support) in order to improve clinical pregnancy rates and prevent miscarriage. The luteal phase becomes shorter and menstruation begins earlier than a natural cycle if a pregnancy cannot be achieved, indicative of early demise of corpus luteum (premature luteolysis). Read More

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December 2018

Effect of sex hormone-binding globulin polymorphisms on the outcome of in vitro fertilization-embryo transfer for polycystic ovary syndrome patients: A case-control study.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Gynecology, Linyi People's Hospital, Linyi, China.

Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone-binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization-embryo transfer (IVF-ET) in PCOS patients. PCOS patients who underwent IVF-ET and patients with non-PCOS-related infertility were selected in the study. Read More

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December 2018
1 Read

The effect of orexin B on steroidogenic acute regulatory protein, p450 side chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase gene expression, progesterone and androstenedione secretion by the porcine uterus during early pregnancy and the oestrous cycle.

J Anim Sci 2018 Dec 2. Epub 2018 Dec 2.

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland.

The aim of this study was to investigate the effect of orexin B (OXB) on progesterone (P4) and androstenedione (A4) secretion by porcine endometrial and myometrial tissue explants and on the expression of key steroidogenic proteins and enzymes involved in steroid production. The hormones secretion and the expression of steroidogenic acute regulatory protein (StAR), P450 side-chain cleavage enzyme (CYP11A1) and 3β-hydroxysteroid dehydrogenase (HSD3B1) was analyzed on days 10 to 11, 12 to 13, 15 to 16, 27 to 28 of pregnancy and during the luteal phase of the oestrous cycle (days 10 to 11). Endometrial and myometrial explants were cultured in vitro in the presence of OXB (1, 10 or 100 nM) and OXB (1, 10 or 100 nM) with 1 µM of JNJ (OX2R antagonist). Read More

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December 2018

Thrombin generation during a regular menstrual cycle in women with von Willebrand disease.

Sci Rep 2018 Nov 30;8(1):17467. Epub 2018 Nov 30.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Fluctuations of the sex steroids during the menstrual cycle might significantly influence hemostasis. This association, derived from a number of the observations on healthy women, is yet to be described in females affected by bleeding disorders. The aim of the current study was to assess the changes in hemostatic variables in women with vWD during two phases of the menstrual cycle (follicular and luteal) and to compare it with healthy controls. Read More

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November 2018

Confirmation of ovulation from urinary progesterone analysis: assessment of two automated assay platforms.

Sci Rep 2018 Dec 4;8(1):17621. Epub 2018 Dec 4.

MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

Urinary concentrations of the major progesterone (P4) metabolite pregnanediol-3-glucuronide (PDG) are used to confirm ovulation. We aimed to determine whether automated immunoassay of urinary P4 was as efficacious as PDG to confirm ovulation. Daily urine samples from 20 cycles in 14 healthy women in whom ovulation was dated by ultrasound, and serial weekly samples from 21 women in whom ovulation was unknown were analysed. Read More

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December 2018

[Premenstrual dysphoric disorder is often overlooked].

Ugeskr Laeger 2018 Nov;180(47)

Premenstrual dysphoric disorder (PMDD) is a cluster of severe affective symptoms recurring during the luteal phase of the menstrual cycle, and it affects up to 8% of menstruating women. In Denmark, this disorder is often overlooked. Unlike in the treatment of anxiety and depression, selective serotonin reuptake inhibitors need not be given continuously but can be effective when used only in the luteal phase. Read More

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November 2018

Regulation of steroidogenic function of luteal cells by thrombospondin and insulin in water buffalo (Bubalus bubalis).

Reprod Fertil Dev 2018 Dec 4. Epub 2018 Dec 4.

The present study examined the effect of exogenous thrombospondin 1 (TSP1) on the steroidogenic function of luteal cells cultured in vitro. Furthermore, the transcriptional interaction of insulin with TSP1 and its receptor, cluster of differentiation 36 (CD36) were also investigated. At the highest dose (500 ng mL-1) TSP1 significantly downregulated the expression of the angiogenic marker von Willebrand factor (vWF) and progesterone production in cultured luteal cells. Read More

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December 2018

Filtered reproductive long non-coding RNAs by genome-wide analyses of goat ovary at different estrus periods.

BMC Genomics 2018 Dec 4;19(1):866. Epub 2018 Dec 4.

Key Laboratory of Embryo Development, Reproductive Regulation of Anhui Province, Fuyang Normal University, Fuyang, 236041, Anhui, China.

Background: The goat is an important farm animal. Reproduction is an important process of goat farming. The ovary is the most important reproductive organ for goats. Read More

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December 2018

Oncostatin M and its receptors mRNA regulation in bovine granulosa and luteal cells.

Theriogenology 2018 Nov 22;125:324-330. Epub 2018 Nov 22.

ReproPel, Faculdade de Veterinária, Pelotas, RS, Brazil. Electronic address:

Oncostatin M (OSM) and its receptor (OSMR) are members of the interleukin-6 family cytokines. Although OSM and OSMR expression was detected in human ovaries, their function and regulation during follicle development, ovulation and luteolysis have not been studied in any species. The aim of the present study was to investigate the levels of OSM and OSMR mRNA in bovine ovaries and the effect of OSM treatment on cultured granulosa cells. Read More

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November 2018
1 Read

Menstrual Cycle Phase Does Not Modulate Whole-Body Heat Loss during Exercise in Hot, Dry Conditions.

J Appl Physiol (1985) 2018 Nov 29. Epub 2018 Nov 29.

School of Human Kinetics, University of Ottawa, Canada.

Menstrual cycle phase has long been thought to modulate thermoregulatory function. However, information pertaining to the effects of menstrual phase on time-dependent changes in whole-body dry and evaporative heat exchange during exercise-induced heat stress and the specific heat load at which menstrual phase modulates whole-body heat loss remained unavailable. We therefore used direct calorimetry to continuously assess whole-body dry and evaporative exchange in twelve habitually active, non-endurance trained, eumenorrheic females (21±2 years) within the early-follicular, late-follicular and mid-luteal menstrual phases during three, 30-min bouts of cycling at increasing fixed exercise intensities of 40% (Low), 55% (Moderate) and 70% (High) V̇O, each followed by a 15-min recovery, in hot, dry conditions (40°C, 15% relative humidity). Read More

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November 2018

Decrease in pregnancy rate after endometrial scratch in women undergoing a first or second in vitro fertilization. A multicenter randomized controlled trial.

Hum Reprod 2018 Nov 29. Epub 2018 Nov 29.

CHU de Bordeaux, Endocrinology and Metabolism, Reproductive Medicine Unit, Bordeaux, France.

Study Question: Does endometrial scratch in women undergoing a first or second IVF/ICSI attempt improve the clinical pregnancy rate (CPR)?

Summary Answer: Endometrial scratch (ES) in women undergoing their first or second IVF/ICSI attempt does not enhance the CPR under the technical conditions of our study.

What Is Known Already: Several studies have suggested that physical scratch of the endometrium before an IVF attempt could improve embryo implantation.

Study Design, Size, Duration: This was a randomized controlled multi-center, two-arm, parallel trial. Read More

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November 2018
2 Reads

Changes in Functional Activity of Neutrophils and Monocytes Isolated from the Peripheral Blood of Women at Different Phases of the Menstrual Cycle.

Bull Exp Biol Med 2018 Dec 28;166(2):222-224. Epub 2018 Nov 28.

Research Institute of Immunology, South-Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.

We studied functional activity of neutrophilic granulocytes and monocytes isolated from the peripheral blood of women during the follicular and luteal phases of the menstrual cycle. It was shown that phagocytic activity of neutrophilic granulocytes increases, their intracellular oxygen-dependent bactericidal activity decreases, and the number of monocyte extracellular traps increases in women in the luteal phase of the menstrual cycle in comparison with the follicular phase. Read More

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December 2018

Effect of hypoxia on progesterone production by cultured bovine early and mid luteal cells.

J Reprod Dev 2018 Nov 28. Epub 2018 Nov 28.

Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan.

A major role of the corpus luteum (CL) is to produce progesterone (P4). The CL has immature vasculature shortly after ovulation, suggesting it exists under hypoxic conditions. To elucidate the mechanism involved in regulation of luteal cell function during CL development, we compared the effect of hypoxia on P4 production by cultured bovine early and mid luteal cells. Read More

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November 2018

Do Food Intake and Food Cravings Change during the Menstrual Cycle of Young Women?

Rev Bras Ginecol Obstet 2018 Nov 28;40(11):686-692. Epub 2018 Nov 28.

Faculty of Dentistry, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.

Objective:  The aim of the present study was to assess the anthropometric measures, food intake and food cravings during the menstrual cycle of undergraduate students of the faculty of nutrition.

Methods:  A cross-sectional study was performed with 27 students from a public university in the state of Mato Grosso do Sul, Brazil, who had their food intake evaluated through a 24-hour food recall, their nutritional status evaluated based on anthropometric measures, and food cravings evaluated using the Food Desire Questionnaire. Data were collected during an evaluation in the follicular phase (between the 5 and the 9 day of the menstrual cycle) and another in the luteal phase (LP) (between the 20 and the 25 day of the menstrual cycle). Read More

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November 2018

[Hirsutism secondary to a luteal cyst of the right ovary at the department of internal medicine and endocrinology of the Mali Hospital].

Mali Med 2018 ;33(1):35-37

Service de médecine interne et d'endocrinologie de l'hôpital du Mali.

The authors are reporting here for the first time a documented case of androgen-secreting luteal cyst responsible for primary sterility in Mali. A 26-year married woman with a history of familial hyper androgenia of diabetes and high blood pressure who consulted for hyper androgen syndrome and primary infertility. Hirsutism with the presence of hairs on her chin, upper lips, thorax, forearms, arms, and her legs under waxing which made a Ferriman and Galloway scoreof10. Read More

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January 2018
1 Read

Moving from peripheral blood to local uterine immunophenotype analysis in patients with poor reproductive history: pilot study of a novel technique.

Ir J Med Sci 2018 Nov 27. Epub 2018 Nov 27.

Sims IVF Clinic, Clonskeagh Road, Clonskeagh, Dublin 14, Ireland.

Background: A complete reproductive immunophenotype is poorly described, with most focus on peripheral blood natural killer cells rather than uterine populations. There is debate regarding normal endometrial levels, with no consensus, and much controversy on correlation with implantation/miscarriage.

Aims: Development and validation of a rapid endometrial assessment flow cytometry (FCM) technique, allowing determination of local lymphocyte subset ranges, comparison to peripheral blood, and patient subgroup analysis. Read More

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November 2018

Prostacyclin synthesis and prostacyclin receptor expression in the porcine corpus luteum: evidence for a luteotropic role in vitro.

Biol Reprod 2018 Aug 3. Epub 2018 Aug 3.

Department of Hormonal Action Mechanisms, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland.

The prostacyclin (prostaglandin I2) signaling system is an essential regulator of vascular homeostasis. Since the corpus luteum is a highly vascularized gland, prostacyclin seems to be crucial for luteal development and function. Although progress has been made in understanding the luteotropic action of prostacyclin in mammals, its role in the porcine corpus luteum remains to be determined. Read More

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Early luteal phase progestin concentration influences endometrial function in pregnant mares.

Theriogenology 2018 Nov 19;125:236-241. Epub 2018 Nov 19.

Platform Artificial Insemination and Embryo Transfer, Department for Small Animals and Horses, Vetmeduni Vienna, Veterinärplatz 1, 1210, Vienna, Austria. Electronic address:

In the horse, it is still unclear if and to what extent low progestin concentration contributes to early conceptus loss. In the present study, we have investigated if reduced or elevated progestin concentration in the early luteal phase influences endometrial function and conceptus development. We hypothesized that reduced progestin concentration via delayed downregulation of endometrial progesterone receptors (PR) influences endometrial function in healthy fertile mares while progestin substitution does not. Read More

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November 2018

Negative cognitive styles as risk factors for the occurrence of PMS and PMDD.

J Reprod Infant Psychol 2018 Nov 23:1-16. Epub 2018 Nov 23.

a Department of Clinical Psychology and Psychopathology , Institute of Psychology, University of Lodz , Łódź , Poland.

Background: The purpose of our study is to verify whether elements of cognitive vulnerability to affective disorders may enhance the occurrence of PMS/PMDD.

Methods: In total, 293 women with regular cycles took part in the study. The subjects were exposed to failure during the follicular phase or luteal phase, as appropriate, and the attributional style of failure, cognitive triad inventory (CTI) and presence of biased information processing were determined. Read More

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November 2018
1 Read

Ginger causes subfertility and abortifacient in mice by targeting both estrous cycle and blastocyst implantation without teratogenesis.

Phytomedicine 2018 Nov 31;50:300-308. Epub 2018 Jan 31.

Zoology Department, Faculty of Science, Alexandria University, Alexandria 21511, Egypt.

Background: Due to renowned medicinal properties, Ginger rhizomes (Zingiber officinale Roscoe) used traditionally in the treatment of arthritis, rheumatism, muscular aches, constipation, indigestion, hypertension, dementia, fever, and infectious diseases. As an antiemetic, Ginger is consumed by approximately 80% of pregnant women to treat nausea and vomiting of early pregnancy.

Purpose: The aim of this study is to evaluate the impact of ginger extract on the oestrous cycle and implantation in female mice. Read More

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November 2018
2 Reads

Menstrual cycle-related fluctuations in oxytocin concentrations: A systematic review and meta-analysis.

Front Neuroendocrinol 2018 Nov 17. Epub 2018 Nov 17.

Division of Clinical Psychological Intervention, Department of Education and Psychology, Freie Universität Berlin, Schwendenerstraße 27, 14195 Berlin, Germany. Electronic address:

Oxytocin affects physiological and psychological functions that are often expressed sex-specifically, suggesting interactions between oxytocin and sex hormones. As female sex hormone concentrations change during the menstrual cycle, oxytocin might fluctuate, too. This systematic review and meta-analysis investigated endogenous oxytocin concentrations across menstrual cycle phases in healthy women. Read More

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November 2018
4 Reads

Cyclooxygenase-2 is inhibited in prolonged luteal maintenance induced by intrauterine devices in mares.

Anim Reprod Sci 2018 Dec 10;199:93-103. Epub 2018 Nov 10.

Department of Production Animal Medicine, Faculty of Veterinary Medicine, Helsinki University, Paroninkuja 20, 04920 Saarentaus, Finland. Electronic address:

Treatment with intrauterine devices (IUD) prolongs luteal phases in mares, but the mechanism for this has not been fully elucidated. The aims of the present study were to examine how IUDs affect the uterus to induce longer luteal phases, particularly the role of cyclooxygenase-2 (COX-2) in the maintenance of the corpus luteum (CL). Twenty-seven reproductively normal mares were included: 12 were inseminated (AI), and 15 were fitted with IUDs. Read More

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December 2018

Increased frequency of mind wandering in healthy women using oral contraceptives.

Psychoneuroendocrinology 2018 Nov 8;101:121-127. Epub 2018 Nov 8.

Centre for Studies on Human Stress, Institut universitaire en santé mentale de Montréal, Research Centre, CIUSSS East, Montréal, Québec, Canada; Department of Psychiatry and Addiction, Université de Montréal.

Oral contraceptive (OC) is the most common type of contraceptive method used in industrialized countries. A recent epidemiological study showed that OC use was associated with the onset of depression in young women. Mind wandering, a cognitive process associated with spontaneous thoughts unrelated to the task at-hand, has previously been associated with depressive thinking. Read More

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November 2018
4 Reads

Effect of menstrual cycle on ethanol drinking in rhesus monkeys.

Drug Alcohol Depend 2018 Nov 3;194:205-209. Epub 2018 Nov 3.

Department of Physiology & Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, United States. Electronic address:

Background: Sex differences in the abuse-related effects of alcohol have been demonstrated in the clinic and in preclinical animal models. Less is known about the influence of menstrual cycle phase on drinking.

Methods: In this study, we examined the relationship between menstrual cycle phase and intake of ethanol (EtOH) in five adult female rhesus monkeys. Read More

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November 2018

Kiss1 and its receptor: molecular characterization and immunolocalization in the hypothalamus and corpus luteum of the buffalo.

Anim Biotechnol 2018 Nov 16:1-10. Epub 2018 Nov 16.

a Animal Reproduction Division , Indian Veterinary Research Institute, Izatnagar , Bareilly , Uttar Pradesh , India.

ABSTARCT The neuropeptide kisspeptin (Kp) through its receptor Kiss1r regulates the HPG axis by controlling GnRH release. Since buffalo is a seasonal breeder with problems of delayed puberty and postpartum anestrus, we characterized the Kiss1 and Kiss1r and investigated the immunolocalization in the hypothalamus and corpus luteum (CL). Kiss1 and Kiss1r genes were amplified from gDNA covering the coding region, cloned and sequenced with accession numbers MF168937 and MG820539, respectively. Read More

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November 2018
4 Reads

Luteal phase stimulation, the future of fertility preservation? Retrospective cohort study of luteal phase versus follicular phase stimulation.

J Gynecol Obstet Hum Reprod 2018 Nov 12. Epub 2018 Nov 12.

Department of Gynecology, Centre Médico-Chirurgical d'Obstétrique (CMCO), Hôpitaux universitaires de Strasbourg, France.

Research Question: Is luteal phase stimulation capable of improving fertility preservation?

Materials And Methods: We performed a retrospective cohort study of consecutive ovarian stimulations, during July 2012 and September 2018 at Strasbourg University Teaching Hospital in France. Enrollment criteria were patients aged below 40 who had been referred to our center following a diagnosis of cancer or requiring gonadotoxic treatment. All patients enrolled had regular menstrual cycles and normal ovulation. Read More

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November 2018
1 Read

Early luteal development in Santa Inês ewes superovulated with reduced doses of porcine follicle-stimulating hormone.

Reprod Domest Anim 2018 Nov 12. Epub 2018 Nov 12.

Faculdade de Ciências Agrárias e Veterinárias, UNESP-Universidade Estadual Paulista, Jaboticabal, Brazil.

The aim was to compare the early luteal development in ewes superovulated with different doses of pFSH. Twenty-nine Santa Inês ewes received a progesterone device (CIDR®) for 8 days. Gonadotrophic treatment started on Day 6: G200 (control, n = 9, 200 mg); G133 (n = 10, 133 mg); and G100 (n = 10, 100 mg of pFSH). Read More

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November 2018
1 Read

Expression and regulation of high mobility group AT-hook 1 (HMGA1) during ovulation and luteinisation in rat ovary.

Reprod Fertil Dev 2018 Nov 12. Epub 2018 Nov 12.

High mobility group AT-hook 1 (HMGA1) is able to regulate gene expression and function as a tumour suppressor. The spatiotemporal expression pattern of HMGA1 was investigated in this study. Immature female rats (22-23 days old) were treated with 10 IU, s. Read More

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November 2018
1 Read
2.400 Impact Factor

Effects of oral contraceptives and natural menstrual cycling on environmental learning.

BMC Womens Health 2018 Nov 7;18(1):179. Epub 2018 Nov 7.

Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.

Background: Endogenous ovarian hormones as well as exogenous oestradiol and progesterone play an important role in cognitive processing. Specifically, these hormones play a role in different aspects of memory, both in terms of storage capacity and temporal duration of the mnemonic track. These hormones also have various effects on different types of memory (i. Read More

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November 2018
2 Reads

Expression of vitamin D receptor in the porcine uterus and effect of 1,25(OH)D on progesterone and estradiol-17β secretion by uterine tissues in vitro.

Theriogenology 2018 Oct 30;125:102-108. Epub 2018 Oct 30.

Department of Animal Anatomy and Physiology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-718, Olsztyn, Poland.

Vitamin D acting via its nuclear receptor (VDR) was shown to target many reproductive tissues and regulate their function. Nevertheless, little is known about the role of vitamin D and VDR in the uterus. We hypothesized that VDR expression profile varies in the porcine uterus throughout the course of the estrous cycle, and 1,25(OH)D influences uterine steroidogenic activity. Read More

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October 2018
1 Read

Effect of endometrial mechanical stimulation in an unselected population undergoing in vitro fertilization: futility analysis of a double-blind randomized controlled trial.

J Assist Reprod Genet 2018 Nov 5. Epub 2018 Nov 5.

Department of Obstetrics and Gynecology, Washington University School of Medicine, 4444 Forest Park Avenue, St. Louis, MO, 63108, USA.

Purpose: Implantation failure is a major limiting factor of successful in vitro fertilization (IVF). The objective of this study was to determine if endometrial mechanical stimulation (EMS) by endometrial biopsy in the luteal phase of the cycle prior to embryo transfer (ET) improves clinical outcomes in an unselected subfertile population.

Methods: Double-blind, randomized controlled trial of EMS versus sham biopsy and odds of clinical pregnancy after IVF and embryo transfer. Read More

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November 2018
1 Read

Patient experience in a randomized trial of a weekly progesterone vaginal ring versus a daily progesterone gel for luteal support after in vitro fertilization.

Fertil Steril 2018 Nov;110(6):1101-1108.e3

Texas Fertility Center, Austin, Texas.

Objective: To assess patient experience and convenience of using progesterone vaginal ring (VR) versus vaginal gel for women requiring luteal phase support during in vitro fertilization (IVF).

Design: Post hoc analysis of a prospective, randomized, single-blind, multicenter, phase 3 clinical trial.

Setting: Twenty-two U. Read More

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November 2018
10 Reads

Simplifying luteal phase support in stimulated assisted reproduction cycles.

Authors:
Human M Fatemi

Fertil Steril 2018 Nov;110(6):1035-1036

IVIRMA Middle-East, Abu Dhabi, United Arab Emirates.

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November 2018

Protein to Maximize Whole-Body Anabolism in Resistance-trained Females after Exercise.

Med Sci Sports Exerc 2018 Nov 1. Epub 2018 Nov 1.

Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Canada.

Introduction: Current athlete-specific protein recommendations are based almost exclusively on research in males.

Purpose: Using the minimally-invasive indicator amino acid oxidation (IAAO) technique, we determined the daily protein intake that maximizes whole body protein synthesis and net protein balance after exercise in strength trained females.

Methods: Eight RT females (23 ± 3. Read More

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November 2018
4 Reads

Luteal blood flow measured by Doppler ultrasonography during the first three weeks after artificial insemination in pregnant and non-pregnant Bos indicus dairy cows.

J Reprod Dev 2018 Nov 4. Epub 2018 Nov 4.

Department of Theriogenology, Faculty of Veterinary Science, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.

The objective of this study was to determine if there are differences in luteal size (LS), progesterone (P4), and luteal blood flow (LBF) between pregnant and non-pregnant Bos indicus dairy cows during the first three weeks after insemination, and whether these parameters are related to each other. Lactating cows (n = 13) of mixed parity with a body weight of 430 ± 18 kg (mean ± SD), showing regular estrous cycle were used in the study. All cows were artificially inseminated and were classified as pregnant (embryonic heartbeat on day 30; n = 8) or non-pregnant (inter-estrus interval 17 to 21 days, n = 5). Read More

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November 2018
1.515 Impact Factor

Autoimmune Progesterone Dermatitis Diagnosed by Lymphocyte Transformation Test and Progesterone Provocation Test.

Acta Dermatovenerol Croat 2018 Oct;26(3):276-277

Assoc. Prof. Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology University Hospital Center Zagreb School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;

Autoimmune progesterone dermatitis (APD) is rare autoimmune response to endogenous progesterone or to earlier exposure to exogenous progesterone (1). Skin lesions typically occur due to increases in progesterone during the luteal phase of the menstrual cycle (2). A-31-year-old mother of two children presented to our Department with a 5-year history of pruritic and painful erythematosus macules, papules, and patches on her neck, pectoral region, and face, which appeared 2-3 days before the onset of menses and gradually resolved 7-10 days later (Figure 1). Read More

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October 2018
6 Reads

Effects of intravenous infusion of E.coli lipopolysaccharide in early pregnant cows.

Reproduction 2018 Oct 1. Epub 2018 Oct 1.

H Bollwein, Clinic of Reproductive Medicine, University of Zurich, Zurich, 8057, Switzerland.

The objective was to characterize effects of Escherichia coli LPS (given iv) on corpus luteum (CL) and embryonic viability in early pregnant cattle. Eight non-lactating German Holstein cows were given 0.5 µg/kg LPS on 35 ± 3 d (mean ± SEM) of pregnancy, whereas seven heifers, 41 ± 6 d pregnant, were given 10 ml saline (Control group). Read More

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October 2018
6 Reads

Visualising the boundary sharpness of uterine zonal structures using high-resolution T2-weighted images during the menstrual cycle.

Clin Radiol 2018 Oct 30. Epub 2018 Oct 30.

Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China. Electronic address:

Aim: To investigate whether there is an optimal time in the menstrual cycle to obtain the best image quality of uterine zonal structures with high-field magnetic resonance imaging (MRI).

Materials And Methods: Thirty-eight normal volunteers with regular menstrual cycles underwent pelvic 3 T high-resolution T2-weighted three-dimensional (3D) turbo spin echo (TSE) with variable flip angle MRI examinations during the menstrual phase (MP), follicular phase (FP), peri-ovulatory phase (OP), and luteal phase (LP). Two radiologists blinded evaluated the boundary sharpness of the three zonal structures of the uterine corpus and cervix on mid-sagittal images using a three-point Likert-scale. Read More

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October 2018
2 Reads

Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes.

Hum Reprod Update 2018 Nov 2. Epub 2018 Nov 2.

Department of Clinical Medicine, Aarhus University, Denmark and the Fertility Clinic Skive, Skive Regional Hospital, Resenvej 25, Skive, Denmark.

Background: Elective freezing of all good quality embryos and transfer in subsequent cycles, i.e. elective frozen embryo transfer (eFET), has recently increased significantly with the introduction of the GnRH agonist trigger protocol and improvements in cryo-techniques. Read More

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November 2018
2 Reads

Eating disorders in premenstrual dysphoric disorder: a neuroendocrinological pathway to the pathogenesis and treatment of binge eating.

J Eat Disord 2018 25;6:35. Epub 2018 Oct 25.

2Department of Gynecology, Oslo University Hospital, Ullevål Hospital, Oslo, Norway.

Background: This case report details the presentation, treatment and post-operative outcome of an adult female with co-occurring binge eating disorder and premenstrual dysphoric disorder (PMDD).

Case Presentation: The patient, self-presenting for treatment, reported having struggled with severe, debilitating physical and psychological PMDD symptoms for nearly a decade. After having taken part in a number of unsuccessful first- and second line treatments in primary and secondary care, the patient was referred to tertiary care at the Department of Gynecology at Oslo University Hospital in Norway. Read More

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October 2018
5 Reads

Progesterone levels on pregnancy test day after hormone replacement therapy-cryopreserved embryo transfer cycles and related reproductive outcomes.

Reprod Biomed Online 2018 Oct 6. Epub 2018 Oct 6.

The Fertility Clinic, Skive Regional Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark.

Research Question: Do serum progesterone levels determine ongoing pregnancy rates (OPR) in hormone replacement therapy frozen-thawed embryo transfer (HRT-FET) cycles?

Design: A cohort study of 244 HRT-FET cycles from a Danish public fertility centre. Data from patients undergoing HRT-FET from January 2016 to December 2017 were extracted from a clinical database. All patients had transfer in HRT cycles of autologous embryos frozen on day 5 or 6. Read More

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October 2018
1 Read

Characterization of the Genital Mucosa Immune Profile to Distinguish Phases of the Menstrual Cycle: Implications for HIV Susceptibility.

J Infect Dis 2018 Oct 31. Epub 2018 Oct 31.

Department of Medical Microbiology and Infectious Diseases, Winnipeg, Canada.

Background: Inflammation and immune activation are key factors in sexual transmission of human immunodeficiency virus (HIV). We sought to define the impact of hormonal cycling on the mucosal immune environment and HIV risk in sex workers with a natural menstrual cycle.

Methods: We compared soluble mucosal immune factors and cervical mononuclear cells during hormone titer-defined phases of the menstrual cycle among 37 sex workers from Nairobi, Kenya. Read More

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October 2018
1 Read

Myomectomy scar ectopic pregnancy following a cryopreserved embryo transfer.

Reprod Med Biol 2018 Oct 25;17(4):509-513. Epub 2018 Jun 25.

Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital Niigata Japan.

Case: A 40 year old woman with a history of a myomectomy visited the Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, Niigata, Japan, following 2 years of infertility. Magnetic resonance imaging detected an abnormal endometrial-like pseudo-cavity. A hysterosalpingography also revealed an abnormal accumulation of contrast medium at the myometrial scar site. Read More

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October 2018
1 Read

Expression of fibroblast growth factor 22 (FGF22) and its receptor, FGFR1B, during development and regression of bovine corpus luteum.

Theriogenology 2018 Oct 5;125:1-5. Epub 2018 Oct 5.

Departamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.

The aim of this study was to determine the expression of fibroblast growth factor 22 (FGF22) in the bovine corpus luteum (CL) and to investigate the effects of in vivo total or partial cloprostenol-induced luteolysis on the mRNA abundance of FGF22 and its receptor, FGFR1B. Corpora lutea at different stages of development were then dissected from abattoir ovaries (n = 10/stage); a portion of the tissue samples was fixed in paraformaldehyde and the remaining samples were homogenized and subjected to total RNA extraction. To assess mRNA abundance of target genes during induced luteolysis, nineteen cows were synchronized and then randomly assigned to a Latin square design as follows: Control; 2 administrations of prostaglandin F (PGF, total luteolysis; 2 × 250 μg of cloprostenol sodium) and 1/6PGF (partial luteolysis; 83. Read More

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October 2018
5 Reads

Does extracorporeal shock wave lithotripsy-related pain get affected by menstrual cycle and menopause?

Urolithiasis 2018 Oct 25. Epub 2018 Oct 25.

University of Health Sciences, Antalya Training and Research Hospital, Antalya, Turkey.

The objective of the study was to investigate the effect of the menstrual cycle and menopause on extracorporeal shock wave lithotripsy (ESWL)-related pain outcome. Since March 2017, we evaluated a total of 145 women who underwent the first session of ESWL for renal or ureteral stones. Patients were divided into two groups, as menstruating and menopaused women. Read More

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October 2018

Does anti-Mullerian hormone predict the outcome of further pregnancies in idiopathic recurrent miscarriage? A retrospective cohort study.

Arch Gynecol Obstet 2018 Oct 24. Epub 2018 Oct 24.

Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Purpose: To evaluate whether anti-Mullerian hormone, basal follicle-stimulating hormone, luteinizing hormone, estradiol, and female age would predict future outcomes in women with idiopathic recurrent miscarriage.

Methods: One hundred and sixteen women with idiopathic recurrent miscarriage were retrospectively included. Luteal support with or without a combined treatment regimen for idiopathic recurrent miscarriage was applied in a tertiary-care center in Vienna. Read More

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October 2018
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Supplementation of 17β-estradiol and progesterone in the co-culture medium of bovine oviductal epithelial cells and ovine spermatozoa reduces the sperm kinematics and capacitation.

Reprod Biol 2018 Oct 20. Epub 2018 Oct 20.

Faculdade de Veterinária, Universidade Federal Fluminense, Niterói, RJ, Brazil.

This study investigated the effect that bovine oviductal epithelial cell (BOEC) and ovine spermatozoa co-culture exposed to different hormonal environments had on ram sperm function over the course of a 24-h incubation period. Ram cooled-stored spermatozoa were selected by swim-up and then co-cultured separately for 24 h at 38.5 °C under 5% CO with either: (1) Fert-TALP medium (positive control [POSControl]), (2) Fert-TALP medium supplemented with 17β-estradiol (E2) and progesterone (P4) at concentrations similar to follicular phase (Follicular NEGControl), (3) Fert-TALP medium supplemented with E2 and P4 concentrations similar to luteal phase (Luteal NEGControl), (4) BOEC cultured in the same medium as that of the Follicular NEGControl group (Follicular BOEC group), or (5) BOEC cultured in the same medium as that of the Luteal NEGControl group (Luteal BOEC group). Read More

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October 2018
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Luteal phase progesterone supplementation following induced natural cycle frozen embryo transfer: A retrospective cohort study.

J Gynecol Obstet Hum Reprod 2018 Oct 19. Epub 2018 Oct 19.

Department de medicine de la reproduction, Centre medico-chirurgical et obstetrical (CMCO), 19 rue Louis Pasteur, 67300 Schiltigheim, France.

Introduction: The objective of this study was to assess the impact on the clinical pregnancy rate of luteal phase progesterone treatment in patients being prepared for natural cycle frozen embryo transfer (FET) with induced ovulation.

Material And Methods: This retrospective cohort study collect all the FET protocols over a 6-month period at Strasbourg University Hospital fertility unit between December 2016 and May 2017. In total 293 consecutive patients with regular menstrual cycles were prepared for natural cycle FET during this period. Read More

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October 2018
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Changes in Morphology and Presence of Pinopodes in Endometrial Cells during the Luteal Phase in Women with Infertility Problems: A Pilot Study.

Medicina (Kaunas) 2018 Oct 10;54(5). Epub 2018 Oct 10.

Department of Anatomy, University of Tartu, Ravila 19, 50411 Tartu, Estonia.

To investigate morphological changes in the endometrial epithelial cells of patients with infertility problems. Endometrial biopsies were obtained from 10 women who have undergone several unsuccessful in vitro fertilisation (IVF) procedures. Endometrial biopsies were performed between luteinizing hormone surge days LH+6 to +10 of the natural menstrual cycle. Read More

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October 2018