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Int J Dermatol 2022 May 17. Epub 2022 May 17.

Department of Dermatology and Allergy, University Hospital of Munich (LMU), Munich, Germany.

Background And Objectives: Ocular rosacea is a special manifestation of rosacea with unknown etiology. Eye involvement in rosacea patients is surprisingly common; however, it is often underdiagnosed, resulting in inappropriate treatment. We aimed to provide an updated epidemiologic perspective on ocular rosacea in Germany to improve patient care. Read More

J Cosmet Dermatol 2022 May 16. Epub 2022 May 16.

Public health expertise, Eskişehir Provincial Health Directorate, Eskişehir, Turkey.

Objectives/aims: Rosacea is not only a skin condition but a systemic inflammatory disease that includes chronic inflammation, vascular alterations, and autoimmunity in pathogenesis. We aimed to evaluate the presence of a sensorineural hearing loss in the patients with rosacea in comparison with the healthy control group and, also to compare the audiometric results according to the severity of disease among the patient group.

Methods: Fifty-three patients with erythematelangiectatic or papulopustular type of rosacea and 105 age- and sex-matched healthy controls were included. Read More

J Adv Res 2022 05 1;38:261-274. Epub 2021 Sep 1.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.

Background: Endogenous gasotransmitters are small gaseous mediators that can be generated endogenously by mammalian organisms. The dysregulation of the gasotransmitter system is associated with numerous disorders ranging from inflammatory diseases to cancers. However, the relevance of these endogenous gasotransmitters, prodrug donors and inhibitors in inflammatory dermatological disorders has not yet been thoroughly reviewed and discussed. Read More

Actas Dermosifiliogr 2022 May 10. Epub 2022 May 10.

Servicio de Dermatología, Hospital General Universitario de Valencia, Spain.

Background And Objective: Rosacea is a chronic acneiform skin disorder in which impaired skin barrier function can lead to sensitization to allergens. We aimed to analyze contact allergies in our patients with rosacea.

Material And Methods: Retrospective cohort study of all patients who underwent patch testing in our skin allergy clinic between May 1991 and May 2019. Read More

Carbohydr Res 2022 May 6;517:108580. Epub 2022 May 6.

Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Av. Américo Vespucio 49, Seville, 41092, Spain. Electronic address:

Food allergy induced by lipid transfer proteins (LTPs) of Rosacea fruit family, such as peach, is becoming an important health problem in the Mediterranean area. Current treatments, such as allergen specific immunotherapy (AIT) with allergenic extracts show promising, but in many cases, they need an improvement in homogeneity, availability and induction of tolerant responses. Peptide-based vaccines containing adjuvants, such as carbohydrates for C-type lectin receptors (CLRs) are presented as an alternative approach. Read More

Photodiagnosis Photodyn Ther 2022 May 7;39:102897. Epub 2022 May 7.

Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address:

A 72-year-old woman suffering from multiple actinic keratosis (AK) complicating steroid-induced rosacea received 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) in our outpatient clinic. Both AKs and rosacea achieved remission after one session of PDT. However, an adverse effect of severe acute inflammatory response emerged with lasting hyperpigmentation. Read More

J Cosmet Dermatol 2022 May 9. Epub 2022 May 9.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Skin Therapy Lett 2022 May;27(3):5-7

Center for Clinical Studies, Webster, TX, USA.

Tetracycline-class drugs have been used for first-line treatment of moderate-to-severe acne and rosacea for decades. Recently, a new third generation tetracycline, sarecycline, was US FDA-approved for the treatment of moderate-to-severe acne. This narrow-spectrum tetracycline-derived antibiotic has been shown to be effective with an improved safety profile. Read More

Skinmed 2022 30;20(2):157-158. Epub 2022 Apr 30.

Pathological Anatomy Department, Hospital de Santarém EPE, Santarém, Portugal.

Actas Dermosifiliogr 2022 03 26;113(3):326-328. Epub 2021 Jul 26.

Servicio de Dermatología, Hospital Universitario de Cabueñes, Gijón, Asturias, España.

Actas Dermosifiliogr 2022 03 11;113(3):T326-T328. Epub 2022 Feb 11.

Servicio de Dermatología, Hospital Universitario de Cabueñes, Gijón, Asturias, Spain.

J Cosmet Dermatol 2022 May 4. Epub 2022 May 4.

Sakarya University, Education and Research Hospital, Department of Dermatology, Sakarya, Turkey.

Background: The coronavirus disease 2019 (COVID-19) pandemic has led to a dramatic increase in the use of personal protective equipment (PPE). However, the increased use of PPEs may lead to facial skin complaints.

Aims: This survey study aims to evaluate the effect of the COVID-19 pandemic on facial dermatoses and complaints. Read More

Exp Dermatol 2022 May 2. Epub 2022 May 2.

The Skin Center Dermatology Group, New City, New York, USA.

J Am Acad Dermatol 2022 Apr 28. Epub 2022 Apr 28.

Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Actas Dermosifiliogr 2022 Mar 2. Epub 2022 Mar 2.

Servicio de Dermatología, Hospital Univsersitari Sagrat Cor- Grupo Quirónsalud, Barcelona, Spain.

Photodiagnosis Photodyn Ther 2022 Apr 22:102875. Epub 2022 Apr 22.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Objective: To systematically review the efficacy of photodynamic therapy (PDT) in the treatment of rosacea.

Methods: PubMed, Embase, and Cochrane Library databases were searched for articles published by February 5, 2022, using "photodynamic therapy" and "rosacea" as the keywords.

Results: Nine studies were included in the review. Read More

J Clin Aesthet Dermatol 2022 Apr;15(4):12

Dr. Searle is with the University of Birmingham Medical School in Birmingham, United Kingdom.

Cureus 2022 Mar 19;14(3):e23308. Epub 2022 Mar 19.

Infectious Disease, H. Lee Moffitt Cancer Center, Tampa, USA.

Rosacea granulomatosis is a common, chronic skin disorder that primarily affects the central face, namely the cheek, nose, chin, and central forehead. Although rosacea is mainly a disorder of innate and adaptive immunity, a variety of endogenous and exogenous triggers such as may stimulate it. Often found as commensal organisms in human skin, ​​​​​​​can be parasitic if there is a change in the host's cutaneous environment. Read More

Dermatol Ther 2022 Apr 20:e15528. Epub 2022 Apr 20.

Dermatology Clinic, University of Catania, Catania.

During the COVID-19 pandemic, teledermatology services were set up and enhanced to take care of those benign conditions like cutaneous warts (CWs) which, if undiagnosed or treated with delay, could have worsened, enlarged, and potentially spread to the community. The aim of this hybrid exploratory trial was to combine face-to-face clinical and dermoscopic evaluation with teledermatology follow-up in the management of CWs with a cryogenic pen based on nitrous oxide for home treatment. Twelve adult patients affected by CWs were enrolled. Read More

J Dermatolog Treat 2022 Apr 18:1-4. Epub 2022 Apr 18.

Department of Dermatology, Aalborg University Hospital, Aalborg, Denmark.

Zinc has numerous pharmacological uses in dermatology. Its antioxidant and immunomodulatory properties are thought to correlate with its efficacy in acne vulgaris and leishmaniasis, amongst other cutaneous conditions. We conducted a review of the literature on the use of zinc in dermatology; in particular, we investigated its role in acne vulgaris, hair loss, hidradenitis suppurativa, leishmaniasis, and warts. Read More

Case Rep Dermatol Med 2022 14;2022:9944727. Epub 2022 Apr 14.

Department of Dermatology, University Hospital Center of Tangier, Tetouan, Al Hoceima, Morocco.

To date, the occurrence of adverse events following immunization after COVID-19 vaccine is rare, and their report is still very poor; however, causality assessment is conducted to identify the associated cause, if they occur. In this case report, we present a case of an association of three cutaneous manifestations (maculopapular exanthem with enanthem, site injection reaction, and rosacea exacerbation) occurring three days after taking the first dose of AstraZeneca AZD1222 vaccine. Read More

Dermatol Ther 2022 Apr 14:e15517. Epub 2022 Apr 14.

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

J Invest Dermatol 2022 Apr 10. Epub 2022 Apr 10.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, China; Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China; Department of Dermatology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, China. Electronic address:

Rosacea is a chronic inflammatory skin disorder that manifests abnormal enhanced sensitivity to environmental stimuli. The decreased prevalence of rosacea in aged population has been reported, but the underlying mechanism is unclear. In this study, we confirm that the rosacea-like skin inflammation induced by cathelicidin LL37 is alleviated in aged mice and mice with progeria. Read More

Int J Dermatol 2022 Apr 10. Epub 2022 Apr 10.

Division of Dermatology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.

Background: Data on Demodex in the immunosuppressed state is limited, focusing mainly on patients with human immunodeficiency virus and hematological malignancies. The aim of this study was to describe the manifestations of facial demodicosis in diverse immunosuppressive states.

Methods: The medical records of all patients followed at a Demodex outpatient clinic of a tertiary medical center from January 2008 to November 2020 were retrospectively reviewed. Read More

J Inflamm Res 2022 31;15:2141-2156. Epub 2022 Mar 31.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

Objective: Rosacea is a chronic inflammatory skin disease with high morbidity. Previous studies have described the contribution of skin barrier dysfunction (SBD) in the progression of rosacea, but the specific mechanism remains unclear. In this study, we aim to investigate the key genes that may involve SBD-mediated rosacea aggravation. Read More

J Cosmet Dermatol 2022 Apr 7. Epub 2022 Apr 7.

School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University, Bangkok, Thailand.

Background: Acne is a chronic, inflammatory skin disorder of pilosebaceous units. Tranexamic acid (TXA) acts as a plasmin inhibitor to reduce blood loss and is also used to treat rosacea due to its anti-inflammatory effects. Some parts of the pathogenesis of rosacea are similar to inflammatory acne. Read More

JAMA Dermatol 2022 Apr 6. Epub 2022 Apr 6.

Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

Importance: Four distinct rosacea subtypes have traditionally been recognized, but the frequency of these subtypes among patients with rosacea remains unknown.

Objective: To assess the frequency of 4 rosacea subtypes.

Data Sources: This systemic review and meta-analysis included a search of 2 databases, PubMed and Embase, from inception of the databases to November 2, 2021. Read More

Front Med (Lausanne) 2022 15;9:820119. Epub 2022 Mar 15.

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: Blepharitis is a common eye disorder that may be overlooked by patients and clinical practitioners. The symptoms of blepharitis often manifest as irritation, a burning sensation, grittiness, and itchiness and may decrease visual acuity if not treated promptly. Meibomian gland dysfunction (MGD), a common cause of blepharitis, is believed to be associated with increased inflammatory marker levels that may disrupt the composition of lipids produced by the sebaceous glands in the eyelids and ultimately cause tear film instability. Read More

Front Immunol 2022 14;13:881277. Epub 2022 Mar 14.

Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, China.

[This corrects the article DOI: 10.3389/fimmu.2021. Read More