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J Cosmet Dermatol 2021 May 10. Epub 2021 May 10.

Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia.

Background: Treatment options for erythematotelangiectatic rosacea (ETR) are still scarce. Tranexamic acid (TXA) is an antifibrinolytic drug that was recently used for the treatment of ETR.

Aims: to evaluate the efficacy and safety of intradermal microinjections of TXA for ETR. Read More

J Dermatol 2021 May 9. Epub 2021 May 9.

Institut de Recherche Interdisciplinaire en Biologie humaine et moléculaire (IRIBHM), Université libre de Bruxelles (ULB), Brussels, Belgium.

Demodex folliculorum and brevis are commensal mites that live in low densities in human pilosebaceous follicles as part of the normal adult microbiota, but that give rise to demodicosis and, possibly, rosacea, when they proliferate excessively. This proliferation is favored by various factors, including age, marked immunosuppression, sebaceous gland hyperplasia, and hypervascularization-related factors. To study possible factors influencing mite proliferation, we explored the effects of different variables on Demodex densities (Dd) in a retrospective study of two groups of subjects selected on the basis of their clinical diagnosis: Demodex+, consisting of subjects with demodicosis or with centro-facial papulopustules suggesting rosacea (n = 844, mean Dd 263. Read More

Clin Cosmet Investig Dermatol 2021 30;14:407-417. Epub 2021 Apr 30.

Department of Dermatology, Peking Union Medical College Hospital, Beijing, People's Republic of China.

Background: Rosacea is a chronic skin disorder characterized by erythema, flushing, telangiectasia, papules and pustules, phymatous changes, and ocular involvement. The aim of this study was to examine all published research articles in which botulinum toxin was used to treat rosacea and to evaluate the efficacy and safety of this treatment.

Methods: PubMed, Embase, Cochrane Library, and Web of Science database were used to identify articles eligible for systematic review on March 26, 2021. Read More

J Allergy Clin Immunol 2021 May 3. Epub 2021 May 3.

Department of Basic and Translational Sciences, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA-19104, USA. Electronic address:

Cutaneous mast cells (MCs) express Mas-related G protein-coupled receptor-X2 (MRGPRX2; mouse ortholog MrgprB2), which is activated by an ever-increasing number of cationic ligands. Antimicrobial host defense peptides (HDPs) generated by keratinocytes contribute to host defense likely by two mechanisms; one involving direct killing of microbes and the other via MC activation through MRGPRX2. However, its inappropriate activation may cause pseudoallergy and likely contribute to the pathogenesis of rosacea, atopic dermatitis, allergic contact dermatitis, urticaria and mastocytosis. Read More

Int J Dermatol 2021 May 5. Epub 2021 May 5.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

JAAD Case Rep 2021 May 2;11:106-108. Epub 2021 Apr 2.

Department of Dermatology, Henry Ford Health System, Detroit, Michigan.

Front Med (Lausanne) 2021 16;8:626369. Epub 2021 Apr 16.

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Numerous studies have attempted to apply artificial intelligence (AI) in the dermatological field, mainly on the classification and segmentation of various dermatoses. However, researches under real clinical settings are scarce. This study was aimed to construct a novel framework based on deep learning trained by a dataset that represented the real clinical environment in a tertiary class hospital in China, for better adaptation of the AI application in clinical practice among Asian patients. Read More

J Cosmet Dermatol 2021 Apr;20 Suppl 1:28-31

Dermatology Clinic, University of Catania, Catania, Italy.

Background: Topical azelaic acid (AzA) is a common treatment for mild/moderate inflammatory rosacea.

Aims: To assess the efficacy and tolerability of a novel formulation cream containing 15% AzA (anti-inflammatory/anti-oxidant/anti-microbial agent) combined with 1% dihydroavenanthramide D (anti-inflammatory/anti-itch) in inflammatory rosacea using clinical/instrumental evaluation.

Methods: In this multicentre, prospective, open-label trial, 45 patients with mild/moderate inflammatory rosacea enrolled at the Dermatology Clinic of the University of Catania, Naples, and Rome (Italy) were instructed to apply the cream twice daily for 8 weeks. Read More

Arch Dermatol Res 2021 May 2. Epub 2021 May 2.

Department of Dermatology, Xiangya Hospital, Central South University, Xiangya Road, Kaifu District, Changsha, 410008, Hunan, China.

Although various treatments have been proposed for the management of rosacea, achieving complete remission of persistent erythema remains challenging. Short-wave radiofrequency (SWRF) treatment has been shown to repair skin barriers and reduce chronic inflammation. However, limited studies have evaluated the effectiveness of SWRF treatment for erythematotelangiectatic rosacea (ETR). Read More

J Am Acad Dermatol 2021 Apr 28. Epub 2021 Apr 28.

Departament of Dermatology, University of São Paulo Medical School, São Paulo, São Paulo, Brazil.

Ann R Coll Surg Engl 2021 May;103(5):e165-e168

Queen Victoria Hospital NHS Trust, East Grinstead, UK.

Rhinophyma affects predominantly the Caucasian population and is rare in those with Fitzpatrick skin type IV-VI. Diagnosis is based on clinical evaluation. Prominent features include abnormal coloration and texture of skin, impaired vascularity, irregular nodular exophytic growth and telangiectasia. Read More

Br J Dermatol 2021 Apr 29. Epub 2021 Apr 29.

Dermatology Department, Ramon y Cajal University Hospital, University of Alcala, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.

Rosacea is a chronic inflammatory disease that primarily affects young and middle-aged Caucasian women. Its etiology is multifactorial and appears to be determined by genetic predisposition, alteration of the neurovascular and immune response, as well as an altered dialogue with the microbiota. Additionally, the disease has been linked to gastrointestinal disorders such as Helicobacter pylori infection or small intestine bacterial overgrowth and even neurological disorders such as Parkinson's disease, revealing the existence of a brain-gut-skin axis. Read More

Ann Dermatol 2020 Dec 11;32(6):466-472. Epub 2020 Nov 11.

Department of Dermatology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

Background: A recent study suggested a possible role of skin barrier dysfunction in the pathogenesis of rosacea, which leads to irritation symptoms. Gamma linolenic acid (GLA) is an essential omega-6 fatty acid that is known to restore defective epidermal skin barrier. GLA supplementation has not previously been performed in rosacea patients. Read More

Ann Dermatol 2020 Aug 30;32(4):298-305. Epub 2020 Jun 30.

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: The clinical features of inflammatory papular dermatoses of the face are very similar. Their clinical manifestations have been described on the basis of a small number of case reports and are not specific.

Objective: This study aimed to use computer-aided image analysis (CAIA) to compare the clinical features and parameters of inflammatory papular dermatoses of the face and to develop a formalized diagnostic algorithm based on the significant findings. Read More

Ann Dermatol 2020 Aug 30;32(4):265-272. Epub 2020 Jun 30.

Department of Dermatology, Boston University School of Medicine, Boston, MA, USA.

The human microbiome is a rich environment consisting of bacteria, fungi and other commensal microorganisms of the gut, mucosa and skin. The functional role of the gut microbiome includes facilitation in metabolism of macronutrients, maturation of the immune system, and production of pro- or anti-inflammatory signaling molecules and peptides. The identification of these resident organisms has brought about a new understanding of disease processes. Read More

Ann Dermatol 2020 Jun 24;32(3):247-250. Epub 2020 Apr 24.

Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.

Rosacea is a chronic inflammatory skin disease of unknown etiology. We noticed a series of patients who were diagnosed with rosacea as well as obstructive sleep apnea syndrome (OSAS), for which they used a continuous positive airway pressure (CPAP) mask. This case series aims to give insight in the possible relationship between rosacea and the use of a CPAP mask for OSAS. Read More

Ann Dermatol 2020 Jun 24;32(3):189-196. Epub 2020 Apr 24.

Department of Dermatology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

Background: Rosacea is a common skin disease associated with increased expression of cathelicidin, kallikrein 5 (KLK5), toll-like receptor (TLR) 2, and abnormal barrier function. Recently, it was reported that hyaluronan (HA) could influence immune function via various receptors and HA oligosaccharides (oligo-HAs) could suppress TLR-dependent cytokine expression.

Objective: We investigated if oligo-HAs could influence on inflammation and epidermal barrier induced by LL-37, which had a major role in rosacea. Read More

J Cosmet Dermatol 2021 Apr 26. Epub 2021 Apr 26.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: Patients with rosacea often complained of low-tolerance to skincare.

Aim: To examine if the preexisted low-tolerance to skincare is associated with rosacea the occurrence of the Chinese population.

Methods: A retrospective case-control survey of 997 rosacea cases and 1,012 skin-healthy controls was carried out in China. Read More

Actas Dermosifiliogr 2021 Apr 19. Epub 2021 Apr 19.

Servicio de Anatomía Patológica, Hospital Universitario El Bierzo, Ponferrada, España; Servicio de Anatomía Patológica, Hospital de La Reina, Ponferrada, España; Unidad de Investigación. Instituto de Investigación Biomédica de A Coruña (INIBIC). Universidad de A Coruña, A Coruña, España. Electronic address:

This series of 2 articles on dermatopathologic diagnoses reviews conditions in which granulomas form. Part 1 clarifies concepts, discusses the presentation of different types of granulomas and giant cells, and considers a large variety of noninfectious diseases. Some granulomatous diseases have a metabolic origin, as in necrobiosis lipoidica. Read More

Iran J Parasitol 2020 Oct-Dec;15(4):596-601

Department of Medical Microbiology, Faculty of Medicine, Giresun University, Giresun, Turkey.

Background: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. ADA enzyme deficiency results in the loss of functional properties of B and T lymphocytes. species have been reported to be transmitted between humans through close contact and to play a role in the pathogenesis of rosacea, acne vulgaris, perioral dermatitis, seborrhoeic dermatitis, micropapillary-pruritic dermatitis and blepharitis. Read More

Pediatrics 2021 May;147(5)

Cooper Medical School of Rowan University, Camden, New Jersey.

Two adolescent boys presented with acute acneiform eruptions in the setting of recent dupilumab administration. Subsequent investigation via direct scraping of pustules revealed live Demodex mite colonization of the face. These adolescent patients represent a population not commonly associated with Demodex folliculitis, and we theorize their baseline commensal Demodex mite population may have increased as a consequence of dupilumab-induced, focused immunomodulation. Read More

J Cosmet Dermatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Dermatology, Ankara City Hospital, Ankara, Turkey.

Background: Rosacea is a chronic inflammatory skin disease characterized with increased serum and tissue inflammatory mediators. IL-17 is a well-known inflammatory mediator that plays important roles in pathogenesis of inflammatory skin diseases. Previous studies reported that Th17 pathway is activated in rosacea and IL-17, one of Th17 signature cytokines, is elevated in tissue samples of rosacea patients. Read More

J Cosmet Dermatol 2021 Apr 19. Epub 2021 Apr 19.

Department of Dermatology, Peking Union Medical College Hospital, Beijing, China.

Rosacea is a chronic inflammatory disease characterized by facial flushing, erythema, telangiectasia, papules, and pustules. Its pathogenesis has not been fully understood. In 2017, the global ROSacea COnsensus (ROSCO) panel updated the diagnosis, classification, and assessment of rosacea. Read More

J Cosmet Dermatol 2021 Apr 19. Epub 2021 Apr 19.

Department of Dermatology, Gazi University School of Medicine, Ankara, Turkey.

Background: Lasers have great importance in the management of vascular skin lesions.

Aim: To determine the efficacy of 577-nm pro-yellow laser in cure of certain vascular skin diseases.

Material And Methods: Seventy-four patients who are diagnosed as vascular skin diseases were involved in this study. Read More

Clin Exp Dermatol 2021 Apr 17. Epub 2021 Apr 17.

Department of Dermatology, University of California, Davis, Sacramento, CA, USA.

Lupus miliaris disseminatus faciei (LMDF) is a chronic inflammatory dermatosis of unknown etiology, most often seen in young adults. Although many treatment modalities exist for LMDF, treatment guidelines have not been developed and response to therapy is generally unpredictable. Herein, we present transcriptomic analysis of LMDF lesional skin, which revealed a variety of differentially expressed genes linking LMDF to alterations in innate and adaptive Th1 immunity. Read More

J Drugs Dermatol 2021 04;20(4):426-431

Background: Cutaneous rosacea is a common inflammatory skin disorder that often presents with facial papulopustular lesions that are frequently bothersome to patients. Studies have shown oral sarecycline to be effective and safe for acne, with a low risk of side effects that are historically associated with other tetracycline-class drugs such as doxycycline and minocycline, in addition to offering a reduced risk of emergence of resistant bacteria due to its narrow-spectrum of antibiotic activity. Oral sarecycline is FDA-approved for the treatment of acne (2018). Read More

J Drugs Dermatol 2021 Apr;20(4):384-392

Background: Rosacea, an inflammatory skin disease that leads to an impaired skin barrier function commonly involves the face. Symptoms of rosacea can be bothersome and include pain, stinging, burning, itching, and facial flushing. This review explored skin barrier impairment in rosacea and reduced symptomatology when using over the counter (OTC) skincare products. Read More

J Am Acad Dermatol 2021 Apr 20. Epub 2021 Apr 20.

J Clin Aesthet Dermatol 2021 Mar 1;14(3):E53-E57. Epub 2021 Mar 1.

Dr. Jones is with J&S Studies Inc., in College Station, Texas.

FMX103 1.5% is the first and only topical minocycline foam that is approved for the treatment of papulopustular rosacea in adults. We sought to characterize the safety and pharmacokinetics of minocycline under maximal-use conditions of FMX103 1. Read More

J Clin Aesthet Dermatol 2021 Mar 1;14(3):42-45. Epub 2021 Mar 1.

All authors are with Hospital Universitario Centro Dermatológico Federico Lleras in Bogotá, Colombia.

Botulinum toxin has been used to treat persistent erythema and flushing in rosacea for several years. Here, we describe two women and one man, each with rosacea with flushing and permanent erythema refractory to conventional treatment, who achieved satisfactory and lasting results following intradermal application of botulinum toxin. Two different botulinum toxin types were used. Read More