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J Am Acad Dermatol 2020 Jun 1. Epub 2020 Jun 1.

Dermatology Department, American University of Beirut Medical Center, Lebanon. Electronic address:

The genital skin may be affected by a variety of dermatoses, be it inflammatory, infectious, malignant, idiopathic or others. The Red Scrotum Syndrome is characterized by persistent erythema of the scrotum associated with a burning sensation, hyperalgesia, and itching. Its cause is unknown but proposed mechanisms include rebound vasodilation following prolonged topical corticosteroid use and localized erythromelalgia. Read More

JAMA Dermatol 2020 Jun 3. Epub 2020 Jun 3.

Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Australas J Dermatol 2020 Jun 3. Epub 2020 Jun 3.

Department of Dermatology, Şişli Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Indian Dermatol Online J 2020 Mar-Apr;11(2):208-211. Epub 2020 Mar 9.

Department of Skin and Vd, SCB Medical College and Hospital, Cuttack, Odisha, India.

Background: Topical corticosteroids (TCs) are widely used for various indications in dermatology. However, these can cause a plethora of symptoms if overused or abused. Topical steroid damaged face is a relatively new entity which was described in 2008. Read More

J Dtsch Dermatol Ges 2020 May 29. Epub 2020 May 29.

Department of Dermatology and Allergy, Hospital of the Ludwig Maximilian University of Munich, Munich, Germany.

Background: Rosacea is a common chronic inflammatory cutaneous disorder affecting nearly 5.5 % of the adult population. Our aim was to evaluate the prevalence and epidemiology of rosacea and perioral dermatitis (POD) in an ambulatory care setting. Read More

Contact Dermatitis 2020 May 28. Epub 2020 May 28.

Department of Dermatology, University Hospital Antwerp (UZA), Antwerp, Belgium.

Cureus 2020 Apr 24;12(4):e7810. Epub 2020 Apr 24.

Family Medicine, University of South Florida, Tampa, USA.

Tetracycline derivatives are antibiotics such as minocycline and doxycycline that have been commonly utilized for inflammatory dermatological conditions such as acne and rosacea. Hyperpigmentation of the skin, nails, thyroid, oral mucosa, teeth, and bones is a known but rare side effect of prolonged tetracycline use. The hyperpigmentation typically takes months to years to develop. Read More

J Dermatol 2020 May 28. Epub 2020 May 28.

Department of Dermatology, Tokyo Medical University School of Medicine, Tokyo, Japan.

Cont Lens Anterior Eye 2020 May 24. Epub 2020 May 24.

Department of Ophthalmology, School of Medicine, Universidad Nacional de Colombia, Bogota, Colombia.

Purpose: To evaluate the efficacy of topical ivermectin-metronidazole combined therapy in the management of Demodex-associatedblepharitis.

Methods: Sixty patients with a diagnosis of Demodex-associatedblepharitis were recruited in a randomized clinical trial. Thirty receiving topical ivermectin (0. Read More

Acta Derm Venereol 2020 May 25. Epub 2020 May 25.

Department of Dermatology and Venereology, University Hospital of Brest, FR-29200 Brest, France. E-mail:

The prevalence of psychological disorders in patients with common skin diseases was assessed in a large representative sample of the French adult population. General health, as measured by the EQ5D score, was significantly lower if patients reported having rosacea, atopic dermatitis, urticaria, fungal infections, psoriasis or acne. The proportions of participants reporting being extremely anxious or depressed were higher in those who reported having rosacea, atopic dermatitis or contact dermatitis. Read More

J Formos Med Assoc 2020 May 20. Epub 2020 May 20.

Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Translational Research, Center of Excellence for Cancer Research, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Informatics and Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan; National Institute of Cancer Research, National Health Research Institutes, Maioli, Taiwan; Taiwan Microbiota Consortium, Taipei, Taiwan. Electronic address:

Background/purpose: Rosacea has been linked to inflammatory bowel disease and small bowel bacterial overgrowth. We aimed to investigate the fecal microbial profiling and the potential gene functions between rosacea and non-rosacea subjects.

Methods: A case-control study. Read More

J Cosmet Laser Ther 2020 May 22:1-7. Epub 2020 May 22.

Dermatology and Venereology Department, Tanta University Faculty of Medicine , Tanta, Egypt.

Background: Current rosacea treatment focused on symptom suppression to improve patient's quality of life, prevent progression, and sustain remission. The progress of laser therapy has brought about a paradigm shift in the world of treating erythema and telangiectasia. We appraised role of ferritin in pathogenesis of rosacea and consider its value in efficacy of 595 nm pulsed dye laser (PDL) in treatment of rosacea. Read More

J Am Acad Dermatol 2020 May 18. Epub 2020 May 18.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South University, Changsha, Hunan, China; Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Exp Dermatol 2020 May 20. Epub 2020 May 20.

Department of Anatomy & Cell Biology, Gachon University College of Medicine, Incheon, 21936, Republic of Korea.

Rosacea is a skin inflammatory condition accompanied by cutaneous signs such as edema, flushing, erythema, telangiectasia, and pustules. Generally, rosacea is triggered by ultraviolet B (UVB) exposure. When exposed to UVB, skin epidermis thickens and produces elevated levels of pro-inflammatory cytokines, especially keratinocyte-related VEGF, a potent angiogenic factor. Read More

J Cosmet Dermatol 2020 May 20. Epub 2020 May 20.

Department of Dermatology, Istanbul Medeniyet University, Medical Faculty, Göztepe Research and Training Hospital, Istanbul, Turkey.

Background: Data point to the importance of oxidative stress in rosacea. Glutathione S-transferases (GSTs) have substantial roles in a wide variety of oxidative stress-related conditions.

Aim: To evaluate the immunohistochemical staining characteristics of GST alpha (GSTA), mu (GSTM), pi (GSTP), and theta (GSTT) in patients with rosacea. Read More

BMJ Open 2020 May 18;10(5):e032829. Epub 2020 May 18.

Nossal Institute for Global Health, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Introduction: Current evidence indicates an alarming increase in topical steroid (TS) misuse in India. Data regarding the magnitude and characteristics of this problem in rural India, where 68% of the population resides, are insufficient. This study analyses the magnitude, causes, characteristics and consequences of TS misuse in rural India. Read More

J Dermatolog Treat 2020 May 19:1-28. Epub 2020 May 19.

Université Libre de Bruxelles (ULB), Institut de Recherche Interdisciplinaire en Biologie humaine et moléculaire (IRIBHM) & Service de Biostatistique et Informatique médicale (SBIM), Route de Lennik 808/CP602, 1070 Brussels, Belgium.

Patients with rosacea and demodicosis have high facial skin Demodex densities (Dds), which decrease with benzyl benzoate (BB) treatment. To evaluate the impact of topical BB (+crotamiton) treatment on Dds and clinical symptoms during prolonged follow-up and to compare low (12% once daily) and high (12% twice daily or 20-24% once daily) BB dose regimens. This retrospective study included 344 patients (103 rosacea, 241 demodicosis) observed for 7. Read More

J Clin Lab Anal 2020 May 17:e23363. Epub 2020 May 17.

Research and Studies Center on the Integument (CERT), Department of Dermatology, Clinical Investigation Center (CIC INSERM 1431), University Hospital of Besançon, Besançon, France.

Background: Rosacea is a common condition characterized by transient or persistent central facial erythema, and often papules and pustules. Currently, the role of bacterium in the development and progression of rosacea remains controversial. This study aimed to investigate the difference in the physiological conditions and microorganisms between the lesional and non-lesional areas of papulopustular rosacea. Read More

Actas Dermosifiliogr 2020 May 14. Epub 2020 May 14.

Servicio de Dermatología, Hospital Universitario Infanta Sofía, Madrid, Spain.

Background And Objective: Frontal fibrosing alopecia is an increasingly common form of scarring alopecia. The aim of this study was to describe the demographic and clinical characteristics of patients with FFA seen at the trichology unit of a medium-sized regional hospital and to report on treatments used.

Material And Methods: We reviewed the medical records of all patients with FFA seen at the trichology unit of Hospital Universitario Infanta Sofía in Madrid, Spain between May 2016 and May 2018. Read More

J Eur Acad Dermatol Venereol 2020 May 13. Epub 2020 May 13.

Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Most evidence regarding the relationship between cigarette smoking and risk of rosacea are obtained from cross-sectional or case-control studies.

Objective: To examine the association between smoking and risk of developing rosacea.

Methods: Participants were collected from four rounds (2001, 2005, 2009, and 2013) of the Taiwan National Health Interview Survey. Read More

Front Immunol 2020 24;11:703. Epub 2020 Apr 24.

Department of Physiology, Michigan State University, East Lansing, MI, United States.

Mast cells are tissue-resident innate immune cells known for their prominent role in mediating allergic reactions. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a promiscuous G-protein coupled receptor (GPCR) expressed on mast cells that is activated by several ligands that share cationic and amphipathic properties. Interestingly, MRGPRX2 ligands include certain FDA-approved drugs, antimicrobial peptides, and neuropeptides. Read More

J Trace Elem Med Biol 2020 Apr 17;61:126531. Epub 2020 Apr 17.

Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, Poland. Electronic address:

Background: Metronidazole with well-soluble silver nitrate forms a complex with potent activity (synergism) against bacterial strains and fungi with simultaneous lower side effect than in the case of the two agents administered separately. This study aimed to establish effectiveness in the treatment of ocular rosacea with new formulation of drops and ointment with silver(I) complex of metronidazole.

Methods: Three patients suffering from serious ophthalmic complications of acne rosacea were treated with drops and ointments applied 3 times a day for 3 months. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Feb;45(2):165-168

Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China

Objectives: To explore the relationship between the incidence of rosacea and drinking, smoking, gender or age, and to provide some basis for the diagnosis, treatment and mechanism of rosacea.

Methods: A total of 1 180 patients with rosacea and 1 008 non-rosacea patients diagnosed in the Department of Dermatology of Xiangya Hospital were included in the study. Logistic analysis was performed on the incidence factors, and the differences between the two groups in different age groups were compared. Read More

J Eur Acad Dermatol Venereol 2020 May 7. Epub 2020 May 7.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Cutaneous angiosarcoma (cAS) is a rare malignant aggressive vascular tumor and includes three variants: cAS affecting the head and neck (Wilson-Jones type), post-radiation cAS, and cAS associated with chronic lymphoedema (Stewart-Treves syndrome). The diagnosis is often delayed, because cAS is frequently clinically misdiagnosed as hematoma, rosacea, cellulitis or eczema. The diagnosis of cAS may be difficult also for the pathologists and the tumor may be misdiagnosed as a benign vascular lesion. Read More

Lasers Surg Med 2020 May 6. Epub 2020 May 6.

Aclaris Therapeutics, Inc., 640 Lee Road, Suite 200, Wayne, Pennsylvania, 19087.

Background And Objectives: The objectives of this study were to evaluate the safety, tolerability, and efficacy of oxymetazoline hydrochloride cream, 1% (oxymetazoline) when used as an adjunctive treatment with energy-based therapy for patients with moderate to severe facial erythema associated with rosacea.

Study Design/materials And Methods: In this Phase 4, multicenter, interventional, open-label study, eligible patients received one of four energy-based therapies (potassium titanyl phosphate laser, intense pulsed light therapy, pulsed-dye laser Vbeam Perfecta, or pulsed-dye laser Cynergy) on day 1 and day 29 and once-daily application of oxymetazoline on days 3 through 27 and days 31 through 56. Improvement from baseline in Clinician Erythema Assessment (CEA) score, patient satisfaction measures, incidence of treatment-emergent adverse events (TEAEs), and worsening from baseline on dermal tolerability assessments and the Clinician Telangiectasia Assessment (CTA) were assessed. Read More

Ocul Surf 2020 May 4. Epub 2020 May 4.

Section of Academic Ophthalmology, School of Life Course Sciences, Faculty of Life Sciences and Medicine (FoLSM), King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, United Kingdom; Department of Ophthalmology, King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, London, United Kingdom.

Purpose: To investigate the prevalence of dry eye among all adult age categories and to discover independent risk factors by investigating a wide range of etiological categories.

Methods: A cross-sectional association study including 79,866 voluntary participants aged 20-94 years of the population-based Lifelines Cohort Study in the Netherlands.

Results: Overall, 9. Read More

Clin Cosmet Investig Dermatol 2020 21;13:299-308. Epub 2020 Apr 21.

Bio Basic Europe Srl, Milan, Italy.

Introduction: Rosacea is a chronic multifactorial skin disorder mainly affecting facial skin with an estimated prevalence of about 5% worldwide. Its main symptoms, occurring early during pathology development, are skin dehydration, redness, erythema, and telangiectasia. Given the lack of a resolutive cure, therapeutic approaches able to relieve the main symptoms are needed. Read More

Br J Dermatol 2020 May 4. Epub 2020 May 4.

Department of Dermatology, Stanford University School of Medicine, United States.

Currently, few systemic medications are effective for rosacea. Recent research has shown elevation of interleukin (IL)-17A in rosacea. To assess if the IL-17A inhibitor, secukinumab, could improve moderate to severe papulopustular rosacea (PPR), an exploratory, open-label, single-arm investigator initiated clinical trial in adults with moderate to severe PPR was performed after Stanford Human Subjects Panel approval. Read More

J Eur Acad Dermatol Venereol 2020 May 3. Epub 2020 May 3.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Rosacea is a chronic inflammatory dermatosis that may manifest with flushing, erythema, telangiectasia, papules and pustules, or phymatous changes, occasionally with ocular involvement. It was widely accepted that rosacea typically occurs in people aged 30-50 years old. However, the youngest rosacea patient reported was an eight-year-old girl, inspiring dermatologists to pay more attention to the evaluation of rosacea among younger populations. Read More

J Am Acad Dermatol 2020 Apr 29. Epub 2020 Apr 29.

Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Flushing and erythema are frequent skin symptoms in rosacea. As their adequate treatment remains a clinical challenge, new treatment options are explored, such as oral β-blockers.

Objective: To evaluate the efficacy of oral β-blockers for rosacea-associated facial flushing and erythema. Read More

J Am Acad Dermatol 2020 Apr 28. Epub 2020 Apr 28.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, Hunan, 410008, PR China. Electronic address:

Background: Rosacea is recognized as a chronic inflammatory cutaneous disorder associated with multiple systemic illnesses. However, the association between rosacea and cardiometabolic disease (CMD) remains controversial.

Objective: To evaluate the association between rosacea and CMD by a systematic review and meta-analysis. Read More

Exp Ther Med 2020 Jun 20;19(6):3543-3550. Epub 2020 Mar 20.

Department of Dermatology, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou, Gansu 730050, P.R. China.

The aim of the present study was to evaluate the clinical efficacy and safety of 540 nm-wavelength intense pulsed light (IPL) for the treatment of telangiectasia in late-stage rosacea. Between July 2013 and January 2016, patients with rosacea who tested positive for were recruited. Patients received anti-mite therapy and were then randomly apportioned to receive either three 540 nm-IPL treatments at 4-week intervals (IPL group), or no treatment (control group). Read More

J Clin Med 2020 Apr 24;9(4). Epub 2020 Apr 24.

Department of Dermatology, Medical University of Vienna, 1090 Vienna, Austria.

Dupilumab is the first biological treatment approved for moderate-to-severe atopic dermatitis (AD). Efficacy and safety have been demonstrated in clinical trials, but real-life data is still limited. The objective of this study was to retrospectively evaluate Dupilumab treatment in AD patients in a real-life clinical setting. Read More

PLoS One 2020 27;15(4):e0231078. Epub 2020 Apr 27.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: Certain cosmetic habits may trigger or aggravate rosacea, while there is little published epidemiologic evidence to support this point.

Purpose: To examine if daily skin care habits have an effect on the development of rosacea in Chinese population.

Methods: A multi-center retrospective case-control survey of 1,245 rosacea cases and 1,538 skin-healthy controls was conducted in China. Read More

Indian J Ophthalmol 2020 May;68(5):745-749

Cornea Department, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

Purpose: To report clinical characteristics of Demodex blepharokeratoconjunctivitis affecting young patients.

Methods: This is a retrospective review of 14 patients with the history of chronic red eyes with corneal involvement. All patients were diagnosed with ocular demodicosis based on the results of eyelash sampling. Read More

J Clin Aesthet Dermatol 2020 Mar 1;13(3):22-27. Epub 2020 Mar 1.

Drs. Al Mokadem and Ibrahim are with Zagazig University in Zagazig, Egypt.

Acne and rosacea are common chronic inflammatory skin diseases associated with psychosocial impairment, anxiety, depression, and impaired overall quality of life. Timolol maleate is a potent nonselective β-blocker that causes a combination of vasoconstriction and inhibition of inflammatory mediators. We assessed the clinical efficacy and safety of topical timolol maleate 0. Read More

Dermatol Ther 2020 Apr 19:e13436. Epub 2020 Apr 19.

Department of Dermatology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.

Rosacea fulminans (RF) is a rare dermatological condition which occurs exclusively in women and it is characterized by a sudden onset of painful papules, pustules, cysts, and nodules on the face. A 28-year-old woman was referred to our clinic due to a painful facial eruption within the 13th week of her second pregnancy. After physical examination, the diagnosis of RF during pregnancy was established. Read More

J Eur Acad Dermatol Venereol 2020 Apr 15. Epub 2020 Apr 15.

UCD Charles Institute of Dermatology, University College Dublin, Dublin, Ireland.

Demodex mites are microscopic arachnids found in the normal skin of many mammals. In humans, it is well established that Demodex mite density is higher in patients with the skin condition rosacea, and treatment with acaricidal agents is effective in resolving symptoms. However, pathophysiology of rosacea is complex and multifactorial. Read More

J Dermatolog Treat 2020 Apr 23:1-4. Epub 2020 Apr 23.

Department of Biochemistry, Istanbul Medipol University Hospital, Istanbul, Turkey.

Although the etiopathogenesis of acne rosacea has not yet been clearly elucidated, it has been discussed over the years that autoimmunity may play a role. Genetic and environmental factors are known to have combined effects in the background of autoimmunity, but it has recently been emphasized that an impaired intestinal barrier system is also involved in the development of the disease. Zonulin is a protein that reversibly increases intestinal permeability. Read More

J Dermatol 2020 Jun 14;47(6):592-600. Epub 2020 Apr 14.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Rosacea is a chronic facial skin disease involved in neurovascular dysregulation and neurogenic inflammation. Behavioral factors such as stress, anxiety, depression and sleep were identified to be associated with other inflammatory skin diseases. Few studies have reported sleep status in rosacea. Read More

Int J Impot Res 2020 Apr 14. Epub 2020 Apr 14.

Department of Urology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Patients with rosacea have a higher incidence of depression, embarrassment, social phobia, stress, subjective disease perception and decreased quality of life. Sexual dysfunction is one of the main factors contributing to impaired life quality. The aim of this study is to evaluate the presence of sexual dysfunction in women with rosacea. Read More

Clin Cosmet Investig Dermatol 2020 30;13:253-257. Epub 2020 Mar 30.

Third Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, Department of Dermatovenereology, Prague, Czech Republic.

Background: Facial blemishes resulting from skin disorders have a significant effect on the patient's self-esteem and impact quality of life (QOL).

Aim: To assess the impact of a corrective cosmetic (CC) on QOL on top of skin quality parameters.

Methods: An international observational study was conducted on subjects with visible facial flaws that would benefit from a corrective cosmetic. Read More

Exp Dermatol 2020 Apr 11. Epub 2020 Apr 11.

Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.

Acne and rosacea, despite their similar clinical presentations, follow distinct clinical courses, suggesting that fundamental differences exist in their pathophysiology. We performed a case-control study profiling the skin microbiota in rosacea and acne patients compared to matched controls. Nineteen rosacea and eight acne patients were matched to controls by age ± 5 years, sex and race. Read More

Dermatol Ther 2020 Apr 10:e13394. Epub 2020 Apr 10.

Meram Medicine Faculty, Department of Dermatology, Necmettin Erbakan University, Konya, Turkey.

Discoid lupus erythematosus (DLE) is a chronic inflammatory erythematous skin disease that can be triggered by several factors. Rosacea is another skin disease that causes facial redness and tenderness. Demodex mites have been reported in rosacea and DLE patients commonly in the literature. Read More

Int J Clin Exp Pathol 2020 1;13(3):556-558. Epub 2020 Mar 1.

Department of Dermatology, Zhejiang Hospital No. 12, Lingyin Rd., Hangzhou 310013, Zhejiang Province, China.

We report a 38-year-old man who presented with bilateral conjunctival congestion, hoarseness, and progressively growing pruritic, infiltrated skin lesions that had first begun over the face and neck, and later spread to the trunk and the limbs in 4 months. The clinical appearance of the lesions mimics granulomatous rosacea, acne vulgaris, or pityrosporum folliculitis. Histopathologic examination of the lesions from the face and chest both revealed dense dermal nodular lymphohistiocytic infiltrates which were positive for CD68 and S-100, but negative for CD1a. Read More

Ocul Immunol Inflamm 2020 Apr 7:1-5. Epub 2020 Apr 7.

Centre for Ophthalmology, Eberhard-Karls University Tuebingen, Tuebingen, Germany.

: To investigate the efficacy of once-daily topical treatment of ocular and cutaneous rosacea with ivermectin 1% cream (Soolantra®, Galderma).: Ten patients with rosacea were evaluated in a retrospective monocentric pilot study. Subjective symptoms (measured with the Ocular Surface Disease Index), skin findings, and ocular changes (blepharitis with telangiectasia and meibomian gland dysfunction, conjunctival redness, tear breakup time (TBUT), and fluorescein staining of the cornea) were evaluated. Read More

J Cosmet Dermatol 2020 Apr 6. Epub 2020 Apr 6.

William Beaumont Hospital-Royal Oak, Royal Oak, MI.

Background: Many companies capitalized on treatable skin conditions by providing expensive prescription medications or high-end over-the-counter cosmetics. However, patients have become more apprehensive toward these medications in lieu of their often-detrimental side effect profile and reactivity with sensitive skin.

Aims: We developed a serum was created to counteract this budding problem. Read More