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    Dose, duration, and cost: Opportunities to improve use of long-term oral antibiotics for people with rosacea.
    J Dermatolog Treat 2018 Apr 20:1-21. Epub 2018 Apr 20.
    d Department of Dermatology , Penn State Milton S. Hershey Medical Center , Hershey , PA.
    Background: Systemic antibiotics are often used to treat rosacea and tetracyclines are the most common antibiotic prescribed; however, there is ambiguity among clinical guideline suggestions. Importantly, there is an increasing call to all clinicians to curtail antibiotic use.

    Objective: Investigate the utilization and cost of long-term oral antibiotic use for the treatment of rosacea, including ocular rosacea. Read More

    It Takes One To Know One: Exploring Patient Dialogue On Rosacea Web Based Platforms And Their Potential For Significant Harm.
    J Dermatolog Treat 2018 Apr 20:1-37. Epub 2018 Apr 20.
    a School of Medicine, University of Dundee , Dundee , Scotland.
    Background: Rosacea is a non-curable skin condition, leading patients to turn self-management options from web based platforms. Self-management can be dangerous possibly under-reported.

    Aim: To discover the extent of online material and determine the potential for harm influenced by rosacea internet sources. Read More

    Can the tea tree oil (Australian native plant: Melaleuca alternifolia Cheel) be an alternative treatment for human demodicosis on skin?
    Parasitology 2018 Apr 18:1-11. Epub 2018 Apr 18.
    Department of Pathology,Monash Medical Centre and Department of Medicine,Monash University,Clayton,Victoria,Australia.
    Australian tea tree oil (TTO) and its extract terpinen-4-ol (T4O) are found to be effective in moderating demodex-related diseases. Their possible effects are lowering the mite counts, relieving the demodex-related symptoms and modulating the immune system especially the inflammatory response. This review summarizes the topical treatments of TTO and T4O in human demodicosis, their possible mechanism of actions, side-effects and potential resistance in treating this condition. Read More

    Flushing Disorders Associated with Gastrointestinal Symptoms: Part 2, Systemic Miscellaneous Conditions.
    Clin Med Res 2018 Apr 12. Epub 2018 Apr 12.
    University of Central Florida College of Medicine/HCA Consortium Graduate Medical Education, North Florida Regional Medical Center, 6500 W Newberry Rd, Gainesville, FL 32605
    Flushing disorders with involvement of the gastrointestinal tract represent a heterogeneous group of conditions. In part 1 discussed were neuroendocrine tumors (NET), mast cell activation disorders (MCAD), and hyperbasophilia. In this section are covered the remaining flushing disorders which primarily or secondarily involves the gastrointestinal tract. Read More

    Flushing Disorders Associated with Gastrointestinal Symptoms: Part 1, Neuroendocrine Tumors, Mast Cell Disorders and Hyperbasophila.
    Clin Med Res 2018 Apr 12. Epub 2018 Apr 12.
    University of Central Florida College of Medicine/HCA Consortium Graduate Medical Education, North Florida Regional Medical Center, 6500 W Newberry Rd, Gainesville, FL 32605
    Flushing is the subjective sensation of warmth accompanied by visible cutaneous erythema occurring throughout the body with a predilection for the face, neck, pinnae, and upper trunk where the skin is thinnest and cutaneous vessels are superficially located and in greatest numbers. Flushing can be present in either a wet or dry form depending upon whether neural-mediated mechanisms are involved. Activation of the sympathetic nervous system results in wet flushing, accompanied by diaphoresis, due to concomitant stimulation of eccrine sweat glands. Read More

    Analysis of the effect of temperature on protein abundance in Demodex-associated Bacillus oleronius.
    Pathog Dis 2018 Apr 10. Epub 2018 Apr 10.
    Department of Biology, Maynooth University, Co. Kildare, Ireland.
    A potential role for bacteria in the induction of rosacea has been suggested. The aim of this work was to characterize the effect of temperature on the production of immunostimulatory proteins by Bacillus oleronius-a bacterium to which rosacea patients show sera reactivity and which was originally isolated from a Demodex mite from a rosacea patient. The affected skin of rosacea patients is at a higher temperature than unaffected skin and it was postulated that this might alter the protein expression pattern of B. Read More

    Reduction of Ultraviolet B Light-Induced Erythema by Oxymetazoline and Brimonidine Is Mediated by Different α-Adrenoceptors.
    Exp Dermatol 2018 Apr 10. Epub 2018 Apr 10.
    Research Allergan plc, Irvine, CA, USA.
    When applied topically, oxymetazoline and brimonidine reduce the persistent facial erythema of rosacea; this effect is mediated by cutaneous vasoconstriction induced by postsynaptic activation of α-adrenoceptors. We investigated the α-adrenergic pharmacology of oxymetazoline and brimonidine. Functional activity on α-adrenoceptors was evaluated in vitro in HEK293 cells stably expressing single receptor subtypes using a fluorometric imaging plate reader Ca influx assay. Read More

    Pulsed dye laser treatment of rosacea using a novel 15 mm diameter treatment beam.
    Lasers Surg Med 2018 Apr 10. Epub 2018 Apr 10.
    Syneron-Candela Corporation, Wayland, Massachusetts.
    Background: The pulsed-dye laser has been used to treat facial redness and rosacea for decades. Recent advances in dye laser technology enable 50% higher output energies supporting 50% larger treatment areas, and beam-diameters up to 15 mm with clinically-relevant fluences. In this study, we investigate this novel pulsed-dye laser using a 15 mm diameter beam for treatment of rosacea. Read More

    Chronic blepharitis like picture in patients with Discoid lupus erythematosis - Case series.
    Nepal J Ophthalmol 2017 Jul;9(18):175-179
    Background: Blepharitis is a very common condition encountered in ophthalmology outpatient care department. Dermatological diseases like seborrheic keratopathy and rosacea have been frequently discussed as being associated with blepharitis. However Discoid lupus erythematosis [DLE], an autoimmune condition has only rarely been reported to involve the eyelids mimicking blepharitis. Read More

    Idiopathic facial aseptic granuloma-A diagnostic challenge in pediatric dermatology.
    Pediatr Dermatol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology, Rady Children's Hospital, San Diego, CA, USA.
    Idiopathic facial aseptic granuloma is a distinct, benign lesion that presents in very young children and is characterized by a painless facial nodule that usually appears on the cheek. It is typically characterized by a prolonged course but heals spontaneously or in response to antibiotic treatment. The challenge is to diagnose this entity correctly, ideally based on clinical acumen, to avoid surgical intervention with facial sutures and the resultant scarring and unnecessary treatment interventions. Read More

    A Study on Vitamin D and Cathelicidin Status in Patients with Rosacea: Serum Level and Tissue Expression.
    Ann Dermatol 2018 Apr 21;30(2):136-142. Epub 2018 Feb 21.
    Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.
    Background: Rosacea is a chronic inflammatory disease characterized by centrofacial erythema. Excess cathelicidin is suggested to be important to the pathophysiology of the disease. Recently, presence of a vitamin D response element was revealed in the cathelicidin gene promoter. Read More

    Dermocosmetics for Use in Rosacea: Guideline of the Society for Dermopharmacy.
    Skin Pharmacol Physiol 2018 Mar 29;31(3):147-154. Epub 2018 Mar 29.
    Department of Dermatology and Allergology, Ludwig-Maximilians University, Munich, Germany.
    Rosacea is a widespread inflammatory skin disease that is chronically recurrent and affects predominately the central parts of the face. Affected individuals typically react to numerous cosmetics with redness, burning, and/or worsening of the complexion. Consequently, there is a high demand for dermocosmetics that do not provoke such reactions and are suitable for use in rosacea. Read More

    The impact of age, sex, blepharitis, rosacea and rheumatoid arthritis on mite infection.
    Arch Med Sci 2018 Mar 17;14(2):353-356. Epub 2016 Jun 17.
    Department of Histology and Embryology, Biostructure Center, Medical University of Warsaw, Warsaw, Poland.
    Introduction: Two human-specific species have been described: and . A medical condition caused by the presence of is called demodicosis.

    Material And Methods: The study material comprised eyelashes collected from 1499 patients. Read More

    [THE ROLE OF SOME VAZOACTIVE PEPTIDES IN THE PATHOGENESIS OF EARLY FORMES OF ROSACEA AND THE HEMOSTASIS SYSTEM].
    Georgian Med News 2018 Feb(Issue):94-97
    Tbilisi State Medical University, Department of Dermatology and Venerology, Georgia.
    Recently, the role of vasoactive peptides has been increasingly discussed in the pathogenesis of rosacea. The most attention is paid to the growth factor of the vascular endothelium (VEGF). VEGF affects angiogenesis and survival of immature blood vessels. Read More

    Epidemiological and clinical features of rosacea in Korea: A multicenter cross-sectional study.
    J Dermatol 2018 Mar 25. Epub 2018 Mar 25.
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
    Rosacea is a common chronic inflammatory skin condition. Although several epidemiological and etiologic studies with large sample sizes have been conducted on Caucasians, such data regarding Asian populations are lacking. A total of 580 patients diagnosed with rosacea were enrolled from October 2014 to February 2015 at 14 general hospitals. Read More

    Quality of Life in Individuals with Erythematotelangiectatic and Papulopustular Rosacea: Findings From a Web-based Survey.
    J Clin Aesthet Dermatol 2018 Feb 1;11(2):47-52. Epub 2018 Feb 1.
    Dr. Zeichner is with Mount Sinai Hospital in New York, New York.
    The objective of the study was to evaluate the impact of rosacea on self-perception, emotional, social, and overall well-being and quality of life in individuals with erythematotelangiectatic rosacea (ETR) and papulopustular rosacea (PPR). We distributed a cross-sectional email invitation for participants in the United States to fill out a web-based survey. We included adults who reported having previously received a diagnosis of erythematotelangiectatic rosacea or papulopustular rosacea. Read More

    Genome-Wide Analysis Characterization and Evolution of Genes in , , and .
    Front Genet 2018 2;9:64. Epub 2018 Mar 2.
    School of Life Sciences, Anhui Agricultural University, Hefei, China.
    The SQUAMOSA promoter binding protein (SBP)-box proteins are plant-specific transcriptional factors in plants. SBP TFs are known to play important functions in a diverse development process and also related in the process of evolutionary novelties. gene family has been characterized in several plant species, but little is known about molecular evolution, functional divergence and comprehensive study of gene family in Rosacea. Read More

    Psychosocial aspects of rosacea with a focus on anxiety and depression.
    Clin Cosmet Investig Dermatol 2018 6;11:103-107. Epub 2018 Mar 6.
    Department of Dermatology, University of Rzeszow, Rzeszów, Poland.
    Background: Rosacea is a common, chronic skin condition characterized by facial redness and inflammatory lesions. The disease can lead to social stigmatization and may significantly reduce the quality of life of patients. Psychosocial impact of rosacea can be severe and debilitating; however, it is still underestimated. Read More

    Ivermectin 1% (CD5024) for the treatment of rosacea.
    Expert Opin Pharmacother 2018 Apr 16;19(5):511-516. Epub 2018 Mar 16.
    b Center for Dermatology Research, Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
    Introduction: Rosacea is a chronic and recurrent disease with a variety of cutaneous manifestations. The disorder is a centrofacial inflammatory dermatosis with significant financial, physical and psychological impacts. There are a number of topical, oral and systemic treatments available. Read More

    Phase 2 Randomized, Dose-Ranging Study of Oxymetazoline Cream for Treatment of Persistent Facial Erythema Associated With Rosacea.
    J Drugs Dermatol 2018 Mar;17(3):308-316
    Background: Rosacea is a chronic dermatologic condition with limited treatment options.

    Objective: This phase 2 study evaluated the optimal oxymetazoline dosing regimen in patients with moderate to severe persistent facial erythema of rosacea.

    Methods: Patients were randomly assigned to oxymetazoline cream, 0. Read More

    Pivotal Trial of the Efficacy and Safety of Oxymetazoline Cream 1.0% for the Treatment of Persistent Facial Erythema Associated With Rosacea: Findings from the Second REVEAL Trial.
    J Drugs Dermatol 2018 Mar;17(3):290-298
    Rosacea is a chronic dermatologic condition with limited treatment options, particularly for persistent erythema. This pivotal phase 3 study evaluated oxymetazoline, an a1A-adrenoceptor agonist, for the treatment of moderate to severe persistent erythema of rosacea. Eligible patients were randomly assigned 1:1 to receive oxymetazoline cream 1. Read More

    Assessment of Tear Functions in Patients with Acne Rosacea without Meibomian Gland Dysfunction.
    Ocul Immunol Inflamm 2018 Mar 13:1-4. Epub 2018 Mar 13.
    a Department of Ophthalmology , Ankara Numune Education and Research Hospital , Ankara , Turkey.
    Purpose: To evaluate the results of tear functions in acne rosacea.

    Methods: This prospective study includes 64 eyes of 32 acne rosacea patients without blepharitis and meibomian gland dysfunction and 90 eyes of 45 patients as control group. Tear functions of all were evaluated with ocular surface disease index (OSDI) questionnaire, and measurements of tear osmolarity were performed by using TearLab, Schirmer I tests without anesthesia and fluorescein tear break-up time (TBUT). Read More

    Demodex mites modulate sebocyte immune reaction: Possible role in the pathogenesis of rosacea.
    Br J Dermatol 2018 Mar 12. Epub 2018 Mar 12.
    The Charles Institute of Dermatology, University College Dublin, Belfield, Dublin, Ireland.
    Rosacea is a common facial skin disorder affecting middle-aged adults. Its aetiology is unknown and pathogenesis uncertain. Activation of the host innate immune response has been identified as important. Read More

    Successful therapy of ocular rosacea with topical ivermectin.
    Br J Dermatol 2018 Mar 12. Epub 2018 Mar 12.
    Department of Dermatology, Eberhard Karls University Tuebingen.
    Approximately 75% of cutaneous rosacea patients also suffer from an ocular involvement with blepharitis and meibomian gland dysfunction often presented as chalazia. Clinical symptoms are foreign body sensation, light sensitivity, burning and tearing. This article is protected by copyright. Read More

    Topical Ivermectin: Data Supporting Dual Modes of Action in Rosacea.
    J Clin Aesthet Dermatol 2017 Sep 1;10(9):39-42. Epub 2017 Sep 1.
    Dr. Del Rosso is Research Director at JDR Dermatology Research in Las Vegas, Nevada; Adjunct Clinical Professor of Dermatology at Touro University Nevada, Las Vegas; and with Dermatology and Cutaneous Surgery at Thomas Dermatology in Las Vegas, Nevada.
    Until recently, the potential modes of action of topical ivermectin in rosacea have been speculated but not studied. Short-term studies (12 week), long-term studies (up to 52 weeks), and case report series have now been completed, and topical ivermectin (IVM), formulated as a 1% cream that is applied once daily, has been shown to be effective, well-tolerated, and safe for the treatment of rosacea. This article reviews outcomes from studies that support dual modes of action, including both anti-inflammatory and anti-parasitic effects. Read More

    Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors.
    Sci Rep 2018 Mar 5;8(1):4032. Epub 2018 Mar 5.
    Department of Dermatology, University of California, San Diego, La Jolla, CA, 92037, United States.
    Under homeostatic conditions the release of self-RNA from dying cells does not promote inflammation. However, following injury or inflammatory skin diseases such as psoriasis and rosacea, expression of the cathelicidin antimicrobial peptide LL37 breaks tolerance to self-nucleic acids and triggers inflammation. Here we report that LL37 enables keratinocytes and macrophages to recognize self-non-coding U1 RNA by facilitating binding to cell surface scavenger receptors that enable recognition by nucleic acid pattern recognition receptors within the cell. Read More

    Measurement of Disease Severity in a Population of Rosacea Patients.
    Dermatol Clin 2018 Apr 16;36(2):97-102. Epub 2017 Dec 16.
    Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Public Health Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.
    Severity of rosacea in populations is not well characterized. A validated self-assessment tool was used to study the relationship between rosacea severity and demographic factors. Subjects were adult patients with a clinical diagnosis of rosacea. Read More

    Validity and Reliability of a Rosacea Self-Assessment Tool.
    Dermatol Clin 2018 Apr 28;36(2):93-96. Epub 2017 Nov 28.
    Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.
    The lack of validated rosacea assessment tools is a hurdle in assessing rosacea severity. This article discusses a valid and reliable rosacea severity self-assessment tool (RSAT) to measure rosacea severity. To determine test-retest validity, participants completed the self-assessment twice. Read More

    Genetic Predisposition to Rosacea.
    Dermatol Clin 2018 Apr 16;36(2):87-92. Epub 2017 Dec 16.
    Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.
    Rosacea is a common inflammatory skin disease with a multifaceted pathophysiology, including environmental stressors and neurovascular and immune dysfunction affected by the presence of pathogens. The genetic component of this disorder is not well understood. However, a possible genetic origin in Northern European descendants, family inheritance, twin concordance, and genetic associations with autoimmune disorders attest the genetic predisposition to rosacea. Read More

    Rosacea Pathogenesis.
    Dermatol Clin 2018 Apr 15;36(2):81-86. Epub 2017 Dec 15.
    Department of Dermatology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.
    Rosacea is a chronic inflammatory skin disorder that is not fully understood but involves the complex interplay of genetic factors, immune dysregulation, neurovascular dysregulation, presence of microorganisms, and environmental factors. Increased activation of the immune system occurs through multiple stimuli, including increased levels of cathelicidin and kallikrein 5, Toll-like receptor 2, matrix metalloproteinases, and mast cells within the skin. Their effects are enhanced by the presence of microorganisms and external triggers, such as UV radiation. Read More

    Coping Mechanisms and Resources for Patients Suffering from Rosacea.
    Dermatol Clin 2018 Apr 19;36(2):171-174. Epub 2017 Dec 19.
    Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Social Sciences & Health Policy, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.
    Rosacea has significant quality of life impact. The authors review the literature and Internet sources pertaining to rosacea to identify coping mechanisms and resources available to rosacea patients. MEDLINE and PsycINFO databases were searched to identify pertinent articles. Read More

    Patient Costs Associated with Rosacea.
    Dermatol Clin 2018 Apr 21;36(2):167-170. Epub 2017 Dec 21.
    Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Public Health Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.
    The recalcitrance of rosacea to many treatment options may prompt patients to spend exorbitant amounts of money on unsubstantiated treatment regimens in an effort to achieve relief. The authors examine the relationship between disease severity and treatment cost across several demographic and socioeconomic strata. Familiarization of evidence-based clinical recommendations and consensus guidelines may equip physicians to educate patients about the most efficacious and cost-effective treatment options to assist patients in making cost-conscious decisions in the management of their rosacea. Read More

    Revisiting Rosacea Criteria: Where Have We Been, Where Are We Going, and How Will We Get There?
    Dermatol Clin 2018 Apr 29;36(2):161-165. Epub 2017 Nov 29.
    University of Florida College of Medicine, PO Box 100277, Gainesville, Fl 32610-0277, USA. Electronic address:
    Rosacea is one of the most common and misunderstood dermatologic conditions. Currently, rosacea criteria are based on expert opinion; the definition of rosacea is primarily a reflection of opinion that is prone to bias. It has been more than a decade since the initial criteria were created by the National Rosacea Society. Read More

    Medical Management of Facial Redness in Rosacea.
    Dermatol Clin 2018 Apr 15;36(2):151-159. Epub 2017 Dec 15.
    Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA; Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
    Persistent centrofacial erythema is a predominant component of rosacea. The authors review the topical and systemic treatments for rosacea-related erythema and flushing to aid in treatment decision making in clinical practice. Databases were searched for literature pertaining to treatment options for erythema related to rosacea. Read More

    A Review of the Current Modalities for the Treatment of Papulopustular Rosacea.
    Dermatol Clin 2018 Apr 21;36(2):135-150. Epub 2017 Dec 21.
    Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Public Health Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.
    Papulopustular rosacea is characterized by papules and pustules in the central facial region. We review the literature surrounding the treatment of papulopustular rosacea. PubMed, EMBASE, and Cochrane (Central) databases searches of articles published from 1980 to 2015 were performed using the MeSH terms or keywords "rosacea" and "clinical trial. Read More

    Evaluating and Optimizing the Diagnosis of Erythematotelangiectatic Rosacea.
    Dermatol Clin 2018 Apr 21;36(2):127-134. Epub 2017 Dec 21.
    University of Florida College of Medicine, PO Box 100277, Gainesville, FL 32610-0277, USA.
    Erythematotelangiectatic rosacea is the most prevalent rosacea subtype. Multiple dermatologic conditions may mimic erythematotelangiectatic rosacea. The authors review a comprehensive approach to evaluating subjects with a suspected diagnosis of erythematotelangiectatic rosacea and discuss findings that may warrant further investigation. Read More

    Rosacea Triggers: Alcohol and Smoking.
    Dermatol Clin 2018 Apr 16;36(2):123-126. Epub 2017 Dec 16.
    Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Public Health Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.
    A variety of triggers are thought to exacerbate rosacea. A validated self-assessment tool and survey was used to study the relationship between rosacea severity and triggers. Subjects were adult patients with a clinical diagnosis of rosacea. Read More

    Rosacea Comorbidities.
    Dermatol Clin 2018 Apr 29;36(2):115-122. Epub 2017 Nov 29.
    Department of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, MDC 79, Tampa, FL 33612, USA. Electronic address:
    Rosacea is a chronic inflammatory cutaneous disorder with an unclear pathogenesis. It has been associated with multiple comorbidities, including cardiovascular diseases, malignancies, depression, migraines, dementia, Parkinson disease, gastrointestinal disorders, and autoimmune conditions. The extent, clinical significance, and implications of these associations remain a topic of discussion. Read More

    Psychosocial Burden and Other Impacts of Rosacea on Patients' Quality of Life.
    Dermatol Clin 2018 Apr 29;36(2):103-113. Epub 2017 Nov 29.
    Schulich School of Medicine and Dentistry, Western University, Windsor Campus, Medical Education Building, 401 Sunset Avenue, Windsor, Ontario N9B3P4, Canada; Windsor Clinical Research Inc, 2224 Walker Road, Suite 300B, Windsor, Ontario N8W 5L7, Canada.
    Rosacea is a common and chronic skin disorder with substantial impact on a patients' quality of life. Its varying phenotypic features and facial localization can adversely affect the mental health and socialization of those affected. Although there are no curative interventions, certain therapies have greater effect in improving patient quality of life. Read More

    Use of the microdebrider in the surgical management of rhinophyma.
    Ear Nose Throat J 2018 Jan-Feb;97(1-2):E42-E45
    Department of Otolaryngology-Head and Neck Surgery, University of Ottawa Faculty of Medicine, Ottawa, Ont., Canada.
    Rhinophyma is a disfiguring end-stage manifestation of acne rosacea. It is characterized by a painless hyperplasia of the sebaceous glands and connective tissues of the nose. Numerous surgical modalities-including scalpel surgery, dermabrasion, CO laser ablation, and electrocautery-have been reported with varying results. Read More

    The Rosacea-specific Quality-of-Life instrument (RosQol): Revision and validation among Chinese patients.
    PLoS One 2018 28;13(2):e0192487. Epub 2018 Feb 28.
    Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
    Rosacea is a common chronic facial disorder that affects patients' health-related quality of life; the only questionnaire designed specifically for rosacea is the Rosacea-specific Quality-of-Life instrument (RosQol). However, the questionnaire has not been validated among Chinese patients. This study aimed to validate the Chinese version of the RosQol. Read More

    Rosacea: Epidemiology, pathogenesis, and treatment.
    Dermatoendocrinol 2017 4;9(1):e1361574. Epub 2017 Oct 4.
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Rosacea is a chronic relapsing inflammatory skin disease with a high prevalence among adults of Northern European heritage with fair skin. Symptoms present in various combinations and severity, often fluctuating between periods of exacerbation and remission. Based on morphological characteristics, rosacea is generally classified into four major subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. Read More

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