J Invest Dermatol 2022 Apr 10. Epub 2022 Apr 10.
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, China; Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China; Department of Dermatology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, China. Electronic address:
Rosacea is a chronic inflammatory skin disorder that manifests abnormal enhanced sensitivity to environmental stimuli. The decreased prevalence of rosacea in aged population has been reported, but the underlying mechanism is unclear. In this study, we confirm that the rosacea-like skin inflammation induced by cathelicidin LL37 is alleviated in aged mice and mice with progeria. Read More