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    An empirically generated responder definition for rosacea treatment.
    Clin Cosmet Investig Dermatol 2017 8;10:347-352. Epub 2017 Sep 8.
    Bayer AG, Pharmaceutical Statistics.
    Objective: The aim of this study was to empirically generate a responder definition for the treatment of papulopustular rosacea.

    Methods: A total of 8 multicenter clinical studies on patients with papulopustular facial rosacea were analyzed. All patients were treated with azelaic acid and/or comparator treatments. Read More

    The relationship between migraine and rosacea: Systematic review and meta-analysis.
    Cephalalgia 2017 Jan 1:333102417731777. Epub 2017 Jan 1.
    1 70590 Danish Headache Centre and Department of Neurology, 70590 Rigshospitalet Glostrup , Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
    Objective To systematically review the association between migraine and rosacea. Background Migraine is a complex disorder with episodes of headache, nausea, photo- and phonophobia. Rosacea is an inflammatory skin condition with flushing, erythema, telangiectasia, papules, and pustules. Read More

    Treatment of Rosacea With Concomitant Use of Topical Ivermectin 1% Cream and Brimonidine 0.33% Gel: A Randomized, Vehicle-controlled Study.
    J Drugs Dermatol 2017 Sep;16(9):909-916
    Background: There is currently a lack of data on the simultaneous treatment of different features of rosacea. Individually, ivermectin 1% (IVM) cream and brimonidine 0.33% (BR) gel have demonstrated efficacy on inflammatory lesions and persistent erythema, respectively. Read More

    The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966.
    Acta Derm Venereol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Dermatology, Medical Research Center, PEDEGO Research Group, University of Oulu and Oulu University Hospital, FIN-90029 OYS Oulu, Finland.
    Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade inflammation in order to determine the association between low grade inflammation and skin diseases in an unselected adult population. Read More

    Chemical Peels: Indications and Special Considerations for the Male Patient.
    Dermatol Surg 2017 Sep 4. Epub 2017 Sep 4.
    *Division of Dermatology, Loyola University Medical Center, Maywood, Illinois; †Division of Dermatology & Dermatologic Surgery, Scripps Clinic, La Jolla, California.
    Background: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men.

    Objective: To review the indications for chemical peels with an emphasis on performing this procedure in male patients.

    Materials And Methods: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men. Read More

    Quality of Life Measurement in Acne. Position Paper of the European Academy of Dermatology and Venereology (EADV) Task Forces on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS).
    J Eur Acad Dermatol Venereol 2017 Sep 12. Epub 2017 Sep 12.
    Department of Dermatology and Wound Healing, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
    Acne causes profound negative psychological and social effects on the quality of life (QoL) of patients. The European Dermatology Forum S3-Guideline for the Treatment of Acne recommended adopting a QoL measure as an integral part of acne management. Because of constantly growing interest in health-related QoL assessment in acne and because of the high impact of acne on patients' lives, the European Academy of Dermatology and Venereology Task Force on QoL and Patient Oriented Outcomes and the Task Force on Acne, Rosacea and Hidradenitis Suppurativa have documented the QoL instruments that have been used in acne patients, with information on validation, purposes of their usage, description of common limitations and mistakes in their usage and overall recommendations. Read More

    Treatment of erythemato-telangiectatic rosacea with brimonidine alone or combined with vascular laser based on preliminary instrumental evaluation of the vascular component.
    Lasers Med Sci 2017 Sep 9. Epub 2017 Sep 9.
    Dermatology Clinic, University of Catania, A.O.U. Policlinico-Vittorio Emanuele,Via Santa Sofia, 78, 95123, Catania, Italy.
    The purpose of this study is to evaluate the outcome of a series of patients with erythematotelangiectatic rosacea (ETR) affected by persistent erythema and varying degree of telangiectasias being treated with brimonidine alone or combined with a vascular laser based on the type of vascular components preliminarily evaluated by clinical and instrumental observation. Ten patients affected by ETR were enrolled in a pilot, open study. Instrumental evaluation included erythema-directed digital photography by VISIA-CR™ system and X10 dermoscopy. Read More

    Vitamin B Derivative (Nicotinamide)Appears to Reduce Skin Cancer Risk.
    Skin Therapy Lett 2017 Sep;22(5):1-4
    University of Alberta, Faculty of Medicine and Dentistry, Edmonton, AB, Canada.
    Nicotinamide, an amide form of vitamin B3, has shown the potential to treat a variety of dermatological conditions, including acne, rosacea, and atopic dermatitis. Recent studies have demonstrated the role of nicotinamide, in both topical and oral forms, as a chemopreventive agent against skin cancer. Its anti-carcinogenic role may be due to its ability to enhance DNA repair and prevent ultraviolet (UV)-induced immunosuppression, which is known to contribute to the progression of pre-malignant lesions. Read More

    Lack of significant anti-inflammatory activity with clindamycin in the treatment of rosacea: results of 2 randomized, vehicle-controlled trials.
    Cutis 2017 Jul;100(1):53-58
    Galderma R&D, Sophia Antipolis, France.
    Rosacea is a chronic inflammatory skin disease of the face. The objective of the studies described here was to evaluate the efficacy of clindamycin in the treatment of rosacea. Two multicenter, randomized, vehicle-controlled, phase 2 studies were conducted in participants with moderate to severe rosacea. Read More

    Can Hematologic Parameters be an Indicator of Metabolic Disorders Accompanying Rosacea?
    Acta Dermatovenerol Croat 2017 Jul;25(2):145-150
    Asli Akin Belli, MD, Mugla Sitki Kocman University, Department of Dermatology, 48000, Mugla, Turkey;
    Recently, diverse hematologic parameters have been used as an indicator of the presence or severity of inflammatory and cardiovascular diseases. Our aim was to investigate the ratios of neutrophils to lymphocytes (NL), monocytes to high-density lipoprotein (HDL) cholesterol (MHC), and platelets to lymphocytes (PL) in patients with rosacea in comparison with the control group and determine whether there was a correlation between these ratios and metabolic disorders in patients with rosacea. We conducted a case-control study on 61 patients with rosacea and 60 healthy controls between January 2015 and January 2016 at the Dermatology Outpatient Clinic, Mugla, Turkey. Read More

    Diffuse Papular Eruption of the Face and Eyelids.
    Skinmed 2017 1;15(4):291-292. Epub 2017 Aug 1.
    Department of Dermatology, Saint Louis University, St. Louis, MO;
    A 68-year-old Caucasian woman presented with a 1-month history of a facial and neck eruption (Figure 1A). Her face was covered with 3-mm monomorphic, pink, shiny, papules and rare pustules on an erythematous background. The eruption extended down the neck, her conjunctivae were injected, and her lid margins were inflamed. Read More

    The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming.
    World Allergy Organ J 2017 22;10(1):29. Epub 2017 Aug 22.
    In-FLAME Global Network, of the World Universities Network (WUN), West New York, USA.
    Skin barrier structure and function is essential to human health. Hitherto unrecognized functions of epidermal keratinocytes show that the skin plays an important role in adapting whole-body physiology to changing environments, including the capacity to produce a wide variety of hormones, neurotransmitters and cytokine that can potentially influence whole-body states, and quite possibly, even emotions. Skin microbiota play an integral role in the maturation and homeostatic regulation of keratinocytes and host immune networks with systemic implications. Read More

    Rosacea and Helicobacter pylori: links and risks.
    Clin Cosmet Investig Dermatol 2017 10;10:305-310. Epub 2017 Aug 10.
    First Department of Dermatology and Venereology, Aristotle University Medical School, Thessaloniki, Greece.
    Rosacea is a chronic skin disease characterized by facial erythema and telangiectasia. Despite the fact that many hypotheses have been proposed, its etiology remains unknown. In the present review, the possible link and clinical significance of Helicobacter pylori in the pathogenesis of rosacea are being sought. Read More

    Oxymetazoline hydrochloride cream for facial erythema associated with rosacea.
    Expert Rev Clin Pharmacol 2017 Aug 24:1-6. Epub 2017 Aug 24.
    a Center for Dermatology Research, Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
    Introduction: Rosacea is a chronic skin condition characterized by transient and persistent erythema of the central face. The symptom of persistent erythema can be particularly frustrating for both patients and physicians as it is difficult to treat. Areas covered: Current treatment options for the treatment of rosacea include metronidazole, azelaic acid, sodium sulfacetamide-sulfur, and brimonidine. Read More

    Swiss S1 guideline for the treatment of rosacea.
    J Eur Acad Dermatol Venereol 2017 Aug 21. Epub 2017 Aug 21.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Rosacea (in German sometimes called 'Kupferfinne', in French 'Couperose' and in Italian 'Copparosa') is a chronic and frequently relapsing inflammatory skin disease primarily affecting the central areas of the face. Its geographic prevalence varies from 1% to 22%. The differential diagnosis is wide, and the treatment is sometimes difficult and varies by stage of rosacea. Read More

    Laser treatment of medical skin disease in women.
    Int J Womens Dermatol 2017 Sep 21;3(3):131-139. Epub 2017 Jul 21.
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT.
    Laser treatment is a relatively new and increasingly popular modality for the treatment of many dermatologic conditions. A number of conditions that predominantly occur in women and that have a paucity of effective treatments include rosacea, connective tissue disease, melasma, nevus of Ota, lichen sclerosus (LS), notalgia paresthetica and macular amyloidosis, and syringomas. Laser therapy is an important option for the treatment of patients with these conditions. Read More

    Granulomatous rosacea: a case report.
    J Med Case Rep 2017 Aug 20;11(1):230. Epub 2017 Aug 20.
    Department of Dermatology, University Hospital Hassan II, 202 Hay Mohamadi, Fez, Morocco.
    Background: Granulomatous rosacea is a rare chronic inflammatory skin disease with an unknown origin. The role of Demodex follicularum in its pathogenesis is currently proved.

    Case Presentation: We report a case of a 54-year-old Moroccan man with a 3-month history of erythematous, nonpruritic papules on the lateral side around the eyes. Read More

    Etiologies and management of cutaneous flushing: Nonmalignant causes.
    J Am Acad Dermatol 2017 Sep;77(3):391-402
    Department of Dermatology, Tulane University, New Orleans, Louisiana.
    The flushing phenomenon may represent a physiologic or a pathologic reaction. Although flushing is usually benign, it is prudent that the physician remains aware of potentially life-threatening conditions associated with cutaneous flushing. A thorough investigation should be performed if the flushing is atypical or not clearly associated with a benign underlying process. Read More

    Electrosurgery for the Treatment of Moderate or Severe Rhinophyma.
    Actas Dermosifiliogr 2017 Aug 9. Epub 2017 Aug 9.
    Universidad El Bosque, Bogotá, Colombia; Servicio de Dermatología, Hospital Simón Bolívar, Bogotá, Colombia.
    Rhinophyma, a rare and progressive disfiguring condition, is thought to be the final stage of rosacea. Several surgical treatments are available, including dermabrasion, cryosurgery, scalpel excision, electrosurgery, and carbon dioxide laser. The last 2 techniques are the most effective for the management of rhinophyma. Read More

    The dermatology life quality index (DLQI) and the hospital anxiety and depression (HADS) in Chinese rosacea patients.
    Psychol Health Med 2017 Aug 10:1-6. Epub 2017 Aug 10.
    a Medical Beauty Center , Shanghai Dermatology Hospital , Shanghai , China.
    The study aims to investigate the quality of life (QOL) and the psychological situation in Chinese patients with rosacea. A total of 196 healthy controls and 201 rosacea patients were involved in the final analysis. The general information, the Dermatology Life Quality Index (DLQI) and the Hospital Anxiety and Depression Scale (HADS) were collected. Read More

    Cationic Supramolecular Hydrogels for Overcoming the Skin Barrier in Drug Delivery.
    ChemistryOpen 2017 Aug 17;6(4):585-598. Epub 2017 Jul 17.
    Departament de Farmacologia, Toxicologia i Química TerapèuticaUniversitat de BarcelonaAv. Joan XXIII 27-3108028BarcelonaSpain.
    A cationic bis-imidazolium-based amphiphile was used to form thermoreversible nanostructured supramolecular hydrogels incorporating neutral and cationic drugs for the topical treatment of rosacea. The concentration of the gelator and the type and concentration of the drug incorporated were found to be factors that strongly influenced the gelling temperature, gel-formation period, and overall stability and morphology. The incorporation of brimonidine tartrate resulted in the formation of the most homogeneous material of the three drugs explored, whereas the incorporation of betamethasone resulted in a gel with a completely different morphology comprising linked particles. Read More

    Intense pulsed light for evaporative dry eye disease.
    Clin Ophthalmol 2017 20;11:1167-1173. Epub 2017 Jun 20.
    Dell Laser Consultants, Austin, TX, USA.
    There is a clear association between dry eye disease (DED) and skin inflammatory diseases occurring in close proximity to the eyelids, such as facial skin rosacea. Intense pulsed light (IPL) is widely accepted as a treatment for skin rosacea. A number of recent studies demonstrated that, in patients suffering from meibomian gland dysfunction (MGD), IPL therapy also reduces signs and symptoms of DED. Read More

    Otophyma, Rhinophyma and Telangiectatic Rosacea - A Rare Combination in a Female Patient.
    Open Access Maced J Med Sci 2017 Jul 19;5(4):531-532. Epub 2017 Jul 19.
    Polyclinic for Dermatology and Venerology, University Hospital Lozenetz, Academic Educational Hospital of the Saint Kliment Ohridski University, Medical Faculty, Koziak Street 1, Dermatology, Venereology and Dermatologic Surgery; Onkoderma, Private Clinic for Dermatologic Surgery, Dermatology and Surgery, Sofia 1407, Bulgaria.
    Background: Rosacea is an inflammatory facial dermatosis seen more frequently in adults in their second half of life. The phymas are a particular subtype with sebaceous gland hyperplasia and progressive fibrosis.

    Case Report: We report on the rare simultaneous occurrence of telangiectatic rosacea, otophyma and rhinophyma in a 50-year-old female with psoriatic arthritis, chronic lymphedema of the legs, and metabolic syndrome. Read More

    Treatment of Ocular Rosacea.
    Surv Ophthalmol 2017 Aug 3. Epub 2017 Aug 3.
    Department of Molecular and Cellular Physiology, Albany Medical College; Lions Eye Institute, Department of Ophthalmology, Albany Medical College.
    While rosacea is a common entity with significant cosmetic, socioeconomic, and vision-threatening impacts, this disorder remains incurable. Furthermore, until quite recently, many of the therapeutic options for rosacea had not been assessed through rigorous clinical testing with meaningful outcome measures. Nonetheless, new medical and surgical interventions that have been validated in well-designed trials hold the promise of treating rosacea more effectively. Read More

    Three Cases of Autoimmune Progesterone Dermatitis.
    Ann Dermatol 2017 Aug 21;29(4):479-482. Epub 2017 Jun 21.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Autoimmune progesterone dermatitis is a rare cyclic premenstrual reaction to progesterone produced during the luteal phase of the menstrual cycle. The clinical symptoms of autoimmune progesterone dermatitis overlap with other forms of dermatosis such as erythema multiforme, eczema, fixed drug eruption, urticaria, and angioedema. We experienced 3 cases of autoimmune progesterone dermatitis. Read More

    Long-term management of distinct facial flushing and persistent erythema of rosacea by treatment with carvedilol.
    J Dermatolog Treat 2017 Aug 11:1-4. Epub 2017 Aug 11.
    a Department of Dermatology , Eberhard Karls University Tuebingen, Tuebingen , Germany.
    Background: The treatment of persistent erythema and flushing episodes in patients with rosacea remains a clinical challenge. A possible therapeutic option could be the use of antihypertensive drugs.

    Objectives: We therefore evaluated the effect of the non-selective β-blocker carvedilol in five Caucasian patients. Read More

    Human Permanent Ectoparasites; Recent Advances on Biology and Clinical Significance of Demodex Mites: Narrative Review Article.
    Iran J Parasitol 2017 Jan-Mar;12(1):12-21
    Dept. of Medical Biology, Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland.
    Background: Demodex is a genus of mites living predominantly in mammalian pilosebaceous units. They are commonly detected in the skin of face, with increasing numbers in inflammatory lesions. Causation between Demodex mites and inflammatory diseases, such as rosacea, blepharitis, perioral and seborrhoeic dermatitis or chalazion, is controversially discussed. Read More

    Spotlight on brimonidine topical gel 0.33% for facial erythema of rosacea: safety, efficacy, and patient acceptability.
    Patient Prefer Adherence 2017 6;11:1143-1150. Epub 2017 Jul 6.
    Department of Dermatology, Center for Dermatology Research.
    Background: Brimonidine tartrate is a highly selective alpha 2 agonist that induces direct vasoconstriction of small arteries and veins, thereby reducing vasodilation and edema.

    Objective: To review the current literature regarding the safety, efficacy, and patient acceptability of brimonidine 0.33% gel. Read More

    Late onset asymptomatic pancreatic neuroendocrine tumor - A case report on the phenotypic expansion for MEN1.
    Hered Cancer Clin Pract 2017 21;15:10. Epub 2017 Jul 21.
    Department of Clinical Genomics, Mayo Clinic, Jacksonville, FL 32224 USA.
    Background: Multiple endocrine neoplasia type 1 (MEN1) is a hereditary cancer syndrome associated with several endocrine as well as non-endocrine tumors and is caused by mutations in the MEN1 gene. Primary hyperparathyroidism affects the majority of MEN1 individuals by age 50 years. Additionally, MEN1 mutations trigger familial isolated hyperparathyroidism. Read More

    [Rosacea: New data for better care].
    Ann Dermatol Venereol 2017 Aug - Sep;144(8-9):508-517. Epub 2017 Jul 17.
    Clinique dermatologique, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address:
    In the last 10 years, numerous studies have been published that throw new light on rosacea, in all areas of the disease. This overview summarises all the key developments, based on the indexed bibliography appearing in Medline between 2007 and 2017. Recent epidemiological data show that the prevalence of the disease is doubtless greater than estimated hitherto (more than 10% of adults in some countries) and that we should not overlook rosacea in subjects with skin phototypes V or VI, a condition that exists on all continents. Read More

    Role of Demodex mite infestation in rosacea: A systematic review and meta-analysis.
    J Am Acad Dermatol 2017 Sep 12;77(3):441-447.e6. Epub 2017 Jul 12.
    Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
    Background: The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely.

    Objective: We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea.

    Methods: Systematic literature review and meta-analysis were conducted. Read More

    Lupus miliaris disseminatus faciei: a distinctive facial granulomatous eruption.
    BMJ Case Rep 2017 Jul 14;2017. Epub 2017 Jul 14.
    Department of Dermatology , All India Institute of Medical Sciences, New Delhi, India.
    Facial granulomatous papules are important to recognise, as some of them are associated with significant systemic association, particularly sarcoidosis and certain infectious conditions. Lupus miliaris disseminatus faciei (LMDF) is a benign granulomatous disorder of unknown aetiology characterised by symmetrical, monomorphic, reddish-brown papules on the face. It is not associated with any underlying systemic involvement. Read More

    Light-based devices in the treatment of cutaneous vascular lesions: An updated review.
    J Cosmet Dermatol 2017 Sep 13;16(3):296-302. Epub 2017 Jul 13.
    Skin Laser & Surgery Specialists of New York and New Jersey, New York, NY, USA.
    Background: Light-based devices have been used to treat cutaneous vascular lesions almost since the original development of the laser. After the introduction of the initial continuous wave and pulsed laser systems, the pulsed lasers became the gold standard device. Since then, new devices and methods to treat patients have been introduced. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    An observational descriptive survey of rosacea in the Chinese population: clinical features based on the affected locations.
    PeerJ 2017 7;5:e3527. Epub 2017 Jul 7.
    Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
    Background: There is currently no study that has evaluated the differences in epidemiological and clinical characteristics among rosacea patients according to different facial sites.

    Methods: Clinical and demographic data were obtained from 586 rosacea patients. The patients were divided into four groups based on the main sites involved with the rosacea lesions (full-face, cheeks, nose, or perioral involvement). Read More

    Pediatric blepharokeratoconjunctivitis: is there a 'right' treatment?
    Curr Opin Ophthalmol 2017 Sep;28(5):449-453
    aDivision of Pediatric Ophthalmology, Robert Wood Johnson Medical School, New Brunswick, New Jersey bWills Eye Hospital, Philadelphia, Pennsylvania, USA.
    Purpose Of Review: This article highlights the importance of recognizing blepharokeratoconjunctivitis (BKC) in children and reviews the clinical characteristics and current therapeutic modalities.

    Recent Findings: The mainstay of BKC treatment remains controlling the meibomian gland inflammation and treating cobormid conditions. BKC can occur in the setting of ocular rosacea and Demodex infestation. Read More

    Efficacy and Tolerability of a Cosmetic Skin Care Product With Trans-4-t-butylcyclohexanol and Licochalcone A in Subjects With Sensitive Skin Prone to Redness and Rosacea.
    J Drugs Dermatol 2017 Jun;16(6):605-610

    BACKGROUND: Sensitive skin and rosacea are skin conditions, which may affect the quality of life of the patients considerably. In vitro and in vivo data indicated that the combination of trans-t-butylcyclohexanol and licochalcone A is an effective combination for alleviating the increased sensitivity of rosacea subtype I.

    OBJECTIVE: Objective of this open dermocosmetic study was to investigate the efficacy and tolerability of a skin care product containing the anti-inflammatory licochalcone A and the TRPV1 antagonist trans-t-butylcyclohexanol in subjects with sensitive skin prone to redness and rosacea. Read More

    A Pilot, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of IncobotulinumtoxinA Injections in the Treatment of Rosacea.
    J Drugs Dermatol 2017 Jun;16(6):549-554

    BACKGROUND: Rosacea has a variable presentation. Whereas the pathophysiology may differ, erythema, and flushing are the most consistent findings in all patients.

    OBJECTIVE: To evaluate the safety and efficacy of incobotulinumtoxinA in reducing the severity of rosacea symptoms. Read More

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