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    Honey: A Therapeutic Agent for Disorders of the Skin.
    Cent Asian J Glob Health 2016 4;5(1):241. Epub 2016 Aug 4.
    Dietetics, Nutrition and Biological Sciences, Queen Margaret University, Musselburgh, East Lothian, Scotland, United Kingdom.
    Problems with conventional treatments for a range of dermatological disorders have led scientists to search for new compounds of therapeutic value. Efforts have included the evaluation of natural products such as honey. Manuka honey, for example, has been scientifically recognised for its anti-microbial and wound healing properties and is now used clinically as a topical treatment for wound infections. Read More

    Comorbidities in rosacea: A systematic review and update.
    J Am Acad Dermatol 2017 Oct 26. Epub 2017 Oct 26.
    Department of Internal Medicine, Hotel Dieu de France University Hospital, Beirut, Lebanon; Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
    Background: Rosacea is linked to abnormalities of cutaneous vasculature and dysregulation of the inflammatory response. Recent reports on rosacea have shown a significant association with cardiovascular, gastrointestinal, and psychiatric diseases, all of which may affect morbidity and mortality among these patients.

    Objective: To review available data regarding comorbidities associated with rosacea, discuss their pathogenesis, and highlight the evaluation of affected patients. Read More

    Topical a-Agonist Therapy for Persistent Facial Erythema of Rosacea and the Addition of Oxmetazoline to the Treatment Armamentarium: Where Are We Now?
    J Clin Aesthet Dermatol 2017 Jul 1;10(7):28-32. Epub 2017 Jul 1.
    Dr. Del Rosso is Research Director at JDR Dermatology Research, Las Vegas, Nevada and at Henderson Dermatology Research in Henderson, Nevada; is Adjunct Clinical Professor (Dermatology) at Touro University Nevada, Las Vegas, Nevada; and practices Dermatology and Cutaneous Surgery at Thomas Dermatology in Las Vegas, Nevada.
    The presence of vasoactivity in rosacea-affected skin led to the development of two topical α-adrenergic receptor agonists, brimonidine tartrate 0.5% gel and oxymetazoline hydrochloride 1% cream, both approved by the United States Food and Drug Administration for treatment of persistent facial erythema of rosacea. In this article, the author discusses challenges related to the treatment of persistent facial erythema of rosacea and the use of a-agonist therapy. Read More

    Role of Topical Oxymetazoline for Management of Erythematotelangiectatic Rosacea.
    Ann Pharmacother 2017 Nov 1:1060028017740139. Epub 2017 Nov 1.
    1 Idaho State University, Pocatello, ID, USA.
    Objective: To review and summarize topical oxymetazoline's pharmacology, pharmacokinetics, efficacy, safety, cost, and place in therapy for persistent redness associated with erythematotelangiectatic rosacea.

    Data Sources: Literature searches of MEDLINE (1975 to September 2017), International Pharmaceutical Abstracts (1975 to September 2017), and Cochrane Database (publications through September 2017) using the terms rosacea, persistent redness, α -agonist, and oxymetazoline.

    Study Selection And Data Extraction: Results were limited to studies of human subjects, English-language publications, and topical use of oxymetazoline. Read More

    Real-World Efficacy of Azelaic Acid 15% Gel for the Reduction of Inflammatory Lesions of Rosacea.
    Skin Therapy Lett 2017 11;22(6):5-7
    Department of Dermatology, Weill Medical College of Cornell University, New York, NY, USA.
    Approximately 16 million Americans have rosacea, an inflammatory cutaneous disorder with central facial erythema, papules, pustules, telangiectasia, flushing, and swelling being among the more commonly recognized features. Overexpression of cathelicidin peptide LL-37 has been implicated in the pathophysiology of rosacea. Azelaic acid has been found to inhibit the pathologic expression of cathelicidin, as well as the hyperactive protease activity that cleaves cathelicidin into LL-37. Read More

    Severe Rosacea: A Case Report.
    J Ophthalmic Vis Res 2017 Oct-Dec;12(4):429-433
    Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Purpose: To describe a case of severe rosacea with ocular involvement.

    Case Report: A 28-year-old female patient presented with extensive facial and ocular eruptions. She had a history of treatment with oral prednisolone due to the clinical diagnosis of lupus erythematosus (LE), which had resulted in transient improvement of the lesions, but was followed by exacerbation of the lesions. Read More

    Evidence-based update on rosacea comorbidities and their common physiologic pathways.
    J Am Acad Dermatol 2017 Oct 28. Epub 2017 Oct 28.
    Department of Dermatology, Stanford University School of Medicine, Redwood City, California. Electronic address:
    Rosacea is a common chronic inflammatory disease affecting the facial skin whose etiology and pathophysiology are the subject of much investigation. Risk factors include genetic and environmental elements that may predispose individuals to localized inflammation and abnormal neurovascular responses to stimuli. Recent studies have introduced an array of systemic rosacea comorbidities, such as inflammatory bowel disease and neurologic conditions, that can be challenging to synthesize. Read More

    Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee.
    J Am Acad Dermatol 2017 Oct 28. Epub 2017 Oct 28.
    Department of Dermatology, Pennsylvania State University, Hershey, Pennsylvania.
    In 2002, the National Rosacea Society assembled an expert committee to develop the first standard classification of rosacea. This original classification was intended to be updated as scientific knowledge and clinical experience increased. Over the last 15 years, significant new insights into rosacea's pathogenesis and pathophysiology have emerged, and the disorder is now widely addressed in clinical practice. Read More

    Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources.
    Molecules 2017 Oct 27;22(11). Epub 2017 Oct 27.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Miyagi 980-8574, Japan.
    Stratum corneum tryptic enzyme kallikrein 5 (KLK5) is a serine protease that is involved in the cell renewal and maintenance of the skin barrier function. The excessive activation of KLK5 causes an exacerbation of dermatoses, such as rosacea and atopic dermatitis. Some triterpenoids are reported to suppress the serine proteases. Read More

    Development of Ocular Rosacea following Combined Ipilimumab and Nivolumab Treatment for Metastatic Malignant Skin Melanoma.
    Ocul Oncol Pathol 2017 Sep 2;3(3):188-192. Epub 2017 Feb 2.
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
    Purpose: To report a case of severe ocular rosacea following ipilimumab plus nivolumab treatment in a patient with metastatic malignant skin melanoma.

    Methods: Case report and review of the literature.

    Results: A 68-year-old male with newly diagnosed metastatic malignant cutaneous melanoma was treated with first-line ipilimumab plus nivolumab, which resulted in a partial response. Read More

    Uncaria tomentosa.
    G Ital Dermatol Venereol 2017 Dec;152(6):651-657
    Unit of Dermatology, Department of Medical-Surgical Physiopathology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy -
    Uncaria tomentosa (U. tomentosa) or uña de gato, a species of vine of Rubiaceae family, was used from centuries in various medical conditions. Although there are no randomized controlled trials or published human outcome studies, some conditions reportedly improved by U. Read More

    The Effect of Skin Sebum, pH, and Moisture on Demodex Infestation in Acne Vulgaris and Rosacea Patients.
    Turkiye Parazitol Derg 2017 Sep;41(3):143-147
    Özel Melid Park Hastanesi, Malatya, Türkiye.
    Objective: Acne vulgaris is an inflammatory disease involving the pilosebaceous unit. Rosacea is a chronic inflammatory skin disease that affects the face in particular. This study aimed to determine if skin sebum, pH, and moisture affect the number of Demodex spp. Read More

    Obesity and risk for incident rosacea in US women.
    J Am Acad Dermatol 2017 Dec 21;77(6):1083-1087.e5. Epub 2017 Oct 21.
    Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island. Electronic address:
    Background: The relationship between obesity and rosacea is poorly understood.

    Objective: To conduct the first cohort study to determine the association between obesity and risk for incident rosacea.

    Methods: A total of 89,886 participants were included from the Nurses' Health Study II (1991-2005). Read More

    Efficacy and tolerability of liposomal polyvinylpyrrolidone-iodine hydrogel for the localized treatment of chronic infective, inflammatory, dermatoses: an uncontrolled pilot study.
    Clin Cosmet Investig Dermatol 2017 22;10:373-384. Epub 2017 Sep 22.
    Mundipharma Research GmbH & Co.KG, Limburg (Lahn), Germany.
    Infection is common in many chronic, inflammatory skin conditions but is often difficult to treat, in part due to growing bacterial resistance to antibiotics. Liposomal polyvinyl-pyrrolidone (PVP)-iodine hydrogel has a unique mode of action, combining the antiseptic and anti-inflammatory actions of PVP-iodine with the drug delivery and moisturizing properties of liposomes. We investigated the utility of liposomal PVP-iodine to treat infective dermatoses. Read More

    The Burden of Illness of Erythematotelangiectatic Rosacea and Papulopustular Rosacea: Findings From a Web-based Survey.
    J Clin Aesthet Dermatol 2017 Jun 1;10(6):17-31. Epub 2017 Jun 1.
    Allergan plc, Irvine, California.
    Objective: Evaluate patients' perceptions of rosacea symptoms and treatments. Design: Cross-sectional, web-based survey conducted from May 8 to July 1,2015. Setting: E-mail invitation. Read More

    Increased risk of chronic kidney disease in patients with rosacea: A nationwide population-based matched cohort study.
    PLoS One 2017 2;12(10):e0180446. Epub 2017 Oct 2.
    Department of Geriatrics and Gerontology, Chi-Mei Medical Center, Tainan, Taiwan.
    Background: Rosacea is a chronic inflammatory skin disorder. Inflammation and oxidative stress are involved in the etiopathogenesis of rosacea and chronic kidney disease (CKD). This study aimed to investigate the association between rosacea and CKD. Read More

    Pulsed Dye Laser Treatment Combined with Oral Minocycline Reduces Recurrence Rate of Rosacea.
    Ann Dermatol 2017 Oct 25;29(5):543-547. Epub 2017 Aug 25.
    Department of Dermatology, Inha University School of Medicine, Incheon, Korea.
    Background: The recurrence rate of rosacea was not known very well, but has been reported as 60% in 6 months after withdrawal of the drug. It is not known which treatment can reduce relapses of rosacea effectively.

    Objective: The objective was to identify whether 595 nm-pulsed dye laser (PDL) treatment reduced recurrence rate among rosacea patients who were treated with oral minocycline. Read More

    Emerging Roles for MAS-Related G Protein-Coupled Receptor-X2 in Host Defense Peptide, Opioid, and Neuropeptide-Mediated Inflammatory Reactions.
    Adv Immunol 2017 24;136:123-162. Epub 2017 Jul 24.
    University of Pennsylvania School of Dental Medicine, Philadelphia, PA, United States. Electronic address:
    Mast cells (MCs) are tissue-resident immune cells that contribute to host defense but are best known for their roles in allergic and inflammatory diseases. In humans, MCs are divided into two subtypes based on the protease content of their secretory granules. Thus, human lung MCs contain only tryptase and are known as MCT, whereas skin MCs contain both tryptase and chymase and are known as MCTC. Read More

    Ocular surface inflammation impairs structure and function of meibomian gland.
    Exp Eye Res 2017 Oct;163:78-84
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
    Dysfunction of the meibomian glands alters secreted meibum quantitatively and qualitatively that can lead to damage to the ocular surface epithelium. In response to an unstable tear film cause by meibomian gland dysfunction, ocular surface epithelium is damaged and expresses inflammatory cytokines leading to secondary ocular inflammation. In turn, inflammatory disorders of the palpebral conjunctiva and lid margin may affect the structure and function of meibomian gland. Read More

    Medicinal plants used by inhabitants of the Shigar Valley, Baltistan region of Karakorum range-Pakistan.
    J Ethnobiol Ethnomed 2017 Sep 25;13(1):53. Epub 2017 Sep 25.
    Department of Environmental Sciences, COMSATS, Abbottabad, Pakistan.
    Background: The inhabitants of mountainous terrains depend on folk therapies to treat various ailments; however lack of plant based research and geographical constraints set the traditional knowledge in jeopardy. Present study is the first documentation on traditional uses of plant species by the inhabitants of the Shigar Valley, Karakorum Range, Northern Pakistan.

    Method: Ethnobotanical data were collected over a period from July, 2013 to October, 2016 from 84 respondents, using semi structured questionnaire. Read More

    Rhinophyma: Our experience based on a series of 12 cases.
    Eur Ann Otorhinolaryngol Head Neck Dis 2017 Sep 21. Epub 2017 Sep 21.
    Clínica Clarós, C/Los Vergós, 31, CP 08017, Barcelona, Spain.
    Introduction: Rhinophyma is a rare, benign and unsightly disease of the skin of the nose that was first described a very long time ago, as illustrated by portrait of an old man with a bulbous nose holding his grandson, by Ghirlandaio in 1490. It was described for the first time by Ferdinando Hebra Von (1816-1880), as the third stage of rosacea. The objective of this study is to report the author's experience and propose a new treatment option in the management of rhinophyma. Read More

    An empirically generated responder definition for rosacea treatment.
    Clin Cosmet Investig Dermatol 2017 8;10:347-352. Epub 2017 Sep 8.
    Bayer AG, Pharmaceutical Statistics.
    Objective: The aim of this study was to empirically generate a responder definition for the treatment of papulopustular rosacea.

    Methods: A total of 8 multicenter clinical studies on patients with papulopustular facial rosacea were analyzed. All patients were treated with azelaic acid and/or comparator treatments. Read More

    The relationship between migraine and rosacea: Systematic review and meta-analysis.
    Cephalalgia 2017 Jan 1:333102417731777. Epub 2017 Jan 1.
    1 70590 Danish Headache Centre and Department of Neurology, 70590 Rigshospitalet Glostrup , Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
    Objective To systematically review the association between migraine and rosacea. Background Migraine is a complex disorder with episodes of headache, nausea, photo- and phonophobia. Rosacea is an inflammatory skin condition with flushing, erythema, telangiectasia, papules, and pustules. Read More

    Treatment of Rosacea With Concomitant Use of Topical Ivermectin 1% Cream and Brimonidine 0.33% Gel: A Randomized, Vehicle-controlled Study.
    J Drugs Dermatol 2017 Sep;16(9):909-916
    Background: There is currently a lack of data on the simultaneous treatment of different features of rosacea. Individually, ivermectin 1% (IVM) cream and brimonidine 0.33% (BR) gel have demonstrated efficacy on inflammatory lesions and persistent erythema, respectively. Read More

    The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966.
    Acta Derm Venereol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Dermatology, Medical Research Center, PEDEGO Research Group, University of Oulu and Oulu University Hospital, FIN-90029 OYS Oulu, Finland.
    Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade inflammation in order to determine the association between low grade inflammation and skin diseases in an unselected adult population. Read More

    Chemical Peels: Indications and Special Considerations for the Male Patient.
    Dermatol Surg 2017 Nov;43 Suppl 2:S163-S173
    *Division of Dermatology, Loyola University Medical Center, Maywood, Illinois; †Division of Dermatology & Dermatologic Surgery, Scripps Clinic, La Jolla, California.
    Background: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men.

    Objective: To review the indications for chemical peels with an emphasis on performing this procedure in male patients.

    Materials And Methods: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men. Read More

    Quality of life measurement in acne. Position Paper of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa.
    J Eur Acad Dermatol Venereol 2017 Sep 12. Epub 2017 Sep 12.
    Department of Dermatology and Wound Healing, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
    Acne causes profound negative psychological and social effects on the quality of life (QoL) of patients. The European Dermatology Forum S3-Guideline for the Treatment of Acne recommended adopting a QoL measure as an integral part of acne management. Because of constantly growing interest in health-related QoL assessment in acne and because of the high impact of acne on patients' lives, the European Academy of Dermatology and Venereology Task Force on QoL and Patient Oriented Outcomes and the Task Force on Acne, Rosacea and Hidradenitis Suppurativa have documented the QoL instruments that have been used in acne patients, with information on validation, purposes of their usage, description of common limitations and mistakes in their usage and overall recommendations. Read More

    Treatment of erythemato-telangiectatic rosacea with brimonidine alone or combined with vascular laser based on preliminary instrumental evaluation of the vascular component.
    Lasers Med Sci 2017 Sep 9. Epub 2017 Sep 9.
    Dermatology Clinic, University of Catania, A.O.U. Policlinico-Vittorio Emanuele,Via Santa Sofia, 78, 95123, Catania, Italy.
    The purpose of this study is to evaluate the outcome of a series of patients with erythematotelangiectatic rosacea (ETR) affected by persistent erythema and varying degree of telangiectasias being treated with brimonidine alone or combined with a vascular laser based on the type of vascular components preliminarily evaluated by clinical and instrumental observation. Ten patients affected by ETR were enrolled in a pilot, open study. Instrumental evaluation included erythema-directed digital photography by VISIA-CR™ system and X10 dermoscopy. Read More

    Vitamin B Derivative (Nicotinamide)Appears to Reduce Skin Cancer Risk.
    Skin Therapy Lett 2017 Sep;22(5):1-4
    University of Alberta, Faculty of Medicine and Dentistry, Edmonton, AB, Canada.
    Nicotinamide, an amide form of vitamin B3, has shown the potential to treat a variety of dermatological conditions, including acne, rosacea, and atopic dermatitis. Recent studies have demonstrated the role of nicotinamide, in both topical and oral forms, as a chemopreventive agent against skin cancer. Its anti-carcinogenic role may be due to its ability to enhance DNA repair and prevent ultraviolet (UV)-induced immunosuppression, which is known to contribute to the progression of pre-malignant lesions. Read More

    Lack of significant anti-inflammatory activity with clindamycin in the treatment of rosacea: results of 2 randomized, vehicle-controlled trials.
    Cutis 2017 Jul;100(1):53-58
    Galderma R&D, Sophia Antipolis, France.
    Rosacea is a chronic inflammatory skin disease of the face. The objective of the studies described here was to evaluate the efficacy of clindamycin in the treatment of rosacea. Two multicenter, randomized, vehicle-controlled, phase 2 studies were conducted in participants with moderate to severe rosacea. Read More

    Can Hematologic Parameters be an Indicator of Metabolic Disorders Accompanying Rosacea?
    Acta Dermatovenerol Croat 2017 Jul;25(2):145-150
    Asli Akin Belli, MD, Mugla Sitki Kocman University, Department of Dermatology, 48000, Mugla, Turkey;
    Recently, diverse hematologic parameters have been used as an indicator of the presence or severity of inflammatory and cardiovascular diseases. Our aim was to investigate the ratios of neutrophils to lymphocytes (NL), monocytes to high-density lipoprotein (HDL) cholesterol (MHC), and platelets to lymphocytes (PL) in patients with rosacea in comparison with the control group and determine whether there was a correlation between these ratios and metabolic disorders in patients with rosacea. We conducted a case-control study on 61 patients with rosacea and 60 healthy controls between January 2015 and January 2016 at the Dermatology Outpatient Clinic, Mugla, Turkey. Read More

    Diffuse Papular Eruption of the Face and Eyelids.
    Skinmed 2017 1;15(4):291-292. Epub 2017 Aug 1.
    Department of Dermatology, Saint Louis University, St. Louis, MO;
    A 68-year-old Caucasian woman presented with a 1-month history of a facial and neck eruption (Figure 1A). Her face was covered with 3-mm monomorphic, pink, shiny, papules and rare pustules on an erythematous background. The eruption extended down the neck, her conjunctivae were injected, and her lid margins were inflamed. Read More

    The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming.
    World Allergy Organ J 2017 22;10(1):29. Epub 2017 Aug 22.
    In-FLAME Global Network, of the World Universities Network (WUN), West New York, USA.
    Skin barrier structure and function is essential to human health. Hitherto unrecognized functions of epidermal keratinocytes show that the skin plays an important role in adapting whole-body physiology to changing environments, including the capacity to produce a wide variety of hormones, neurotransmitters and cytokine that can potentially influence whole-body states, and quite possibly, even emotions. Skin microbiota play an integral role in the maturation and homeostatic regulation of keratinocytes and host immune networks with systemic implications. Read More

    Rosacea and Helicobacter pylori: links and risks.
    Clin Cosmet Investig Dermatol 2017 10;10:305-310. Epub 2017 Aug 10.
    First Department of Dermatology and Venereology, Aristotle University Medical School, Thessaloniki, Greece.
    Rosacea is a chronic skin disease characterized by facial erythema and telangiectasia. Despite the fact that many hypotheses have been proposed, its etiology remains unknown. In the present review, the possible link and clinical significance of Helicobacter pylori in the pathogenesis of rosacea are being sought. Read More

    Oxymetazoline hydrochloride cream for facial erythema associated with rosacea.
    Expert Rev Clin Pharmacol 2017 Oct 24;10(10):1049-1054. Epub 2017 Aug 24.
    a Center for Dermatology Research, Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
    Introduction: Rosacea is a chronic skin condition characterized by transient and persistent erythema of the central face. The symptom of persistent erythema can be particularly frustrating for both patients and physicians as it is difficult to treat. Areas covered: Current treatment options for the treatment of rosacea include metronidazole, azelaic acid, sodium sulfacetamide-sulfur, and brimonidine. Read More

    Swiss S1 guideline for the treatment of rosacea.
    J Eur Acad Dermatol Venereol 2017 Nov 21;31(11):1775-1791. Epub 2017 Aug 21.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Rosacea (in German sometimes called 'Kupferfinne', in French 'Couperose' and in Italian 'Copparosa') is a chronic and frequently relapsing inflammatory skin disease primarily affecting the central areas of the face. Its geographic prevalence varies from 1% to 22%. The differential diagnosis is wide, and the treatment is sometimes difficult and varies by stage of rosacea. Read More

    Reinforcement of barrier function and scalp homeostasis by Senkyunolide A to fight against dandruff.
    Int J Cosmet Sci 2017 Aug 18. Epub 2017 Aug 18.
    Sederma, 29 rue du Chemin Vert, Le Perray en Yvelines, F-78610, France.
    Objective: Senkyunolide-A (SENKY) can be isolated from Apium graveolens seed oil obtained using supercritical CO2 extraction. SENKY and its parent compounds, the N-butyl phthalides, have been demonstrated to protect cells from CO poisoning, to prevent diabetes mellitus and to decrease cancer cell proliferation. This study was undertaken to evaluate in vitro and in vivo the effect of SENKY on epidermal function improvement, Malassezia effect control, scalp soothing and dandruff reduction via skin protection-related pathways. Read More

    Laser treatment of medical skin disease in women.
    Int J Womens Dermatol 2017 Sep 21;3(3):131-139. Epub 2017 Jul 21.
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT.
    Laser treatment is a relatively new and increasingly popular modality for the treatment of many dermatologic conditions. A number of conditions that predominantly occur in women and that have a paucity of effective treatments include rosacea, connective tissue disease, melasma, nevus of Ota, lichen sclerosus (LS), notalgia paresthetica and macular amyloidosis, and syringomas. Laser therapy is an important option for the treatment of patients with these conditions. Read More

    Granulomatous rosacea: a case report.
    J Med Case Rep 2017 Aug 20;11(1):230. Epub 2017 Aug 20.
    Department of Dermatology, University Hospital Hassan II, 202 Hay Mohamadi, Fez, Morocco.
    Background: Granulomatous rosacea is a rare chronic inflammatory skin disease with an unknown origin. The role of Demodex follicularum in its pathogenesis is currently proved.

    Case Presentation: We report a case of a 54-year-old Moroccan man with a 3-month history of erythematous, nonpruritic papules on the lateral side around the eyes. Read More

    Etiologies and management of cutaneous flushing: Nonmalignant causes.
    J Am Acad Dermatol 2017 Sep;77(3):391-402
    Department of Dermatology, Tulane University, New Orleans, Louisiana.
    The flushing phenomenon may represent a physiologic or a pathologic reaction. Although flushing is usually benign, it is prudent that the physician remains aware of potentially life-threatening conditions associated with cutaneous flushing. A thorough investigation should be performed if the flushing is atypical or not clearly associated with a benign underlying process. Read More

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