J Autoimmun 2022 04 9;128:102811. Epub 2022 Mar 9.
Department of Dermatology, The Second Xiangya Hospital of Central South University; Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, 410011, China; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, 210042, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China. Electronic address:
Background: Although the contribution of aberrant CD4 T cell signaling to systemic lupus erythematosus (SLE) is well established, its role in cutaneous lupus erythematosus (CLE) skin is largely unknown. Because the rate of systemic manifestations varies in each subtype, resident memory CD4 T cells in lesions that are responsible for only skin-associated tissue responses may vary in each subtype. However, the role of CD4 tissue-resident memory T (CD4 Trm) cells in each CLE subtype remains unclear. Read More