1,117 results match your criteria Lupus Erythematosus Drug-Induced

Anticancer treatments and photosensitivity.

V Sibaud

J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6:51-58

Oncodermatology Department, Claudius REGAUD Institute and Cancer University Institute, Toulouse Oncopole, Toulouse Cedex 9, France.

Drug-induced photosensitivity is associated with a wide range of anticancer treatments, including conventional chemotherapeutic agents, targeted anticancer therapies, and immune checkpoint inhibitors. These dermatologic adverse events can have a major impact on the well-being and quality of life of cancer patients, leading to dose modifications and interruption or discontinuation of anticancer treatments in severe cases. However, the heterogeneous nature of the photosensitive reactions induced by these agents, as well as the common concomitant use of other potentially photosensitizing drugs (antibiotics, voriconazole, nonsteroidal anti-inflammatory drugs, etc. Read More

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Review of secukinumab-induced adverse events of special interest and its potential pathogenesis.

Dermatol Ther 2022 May 25:e15599. Epub 2022 May 25.

Institute of Dermatology, Guangzhou Medical University, Guangzhou, P.R. China.

Although secukinumab has demonstrated high efficacy and favorable safety in moderate-to-severe psoriasis and psoriatic arthritis, patients developing adverse events of special interest (AESI) were reported increasingly in real-world practice. A systematic literature search of the PubMed database was conducted to identify clinical studies or case reports on secukinumab-induced AESI. More than 1077 patients (aged 18-74 years) from 55 studies were reported to have 24 AESI 3 days to 96 weeks after secukinumab treatment. Read More

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Terbinafine Induced Lupus Erythematosus With Progression to Lupus Nephritis.

Cureus 2022 Apr 6;14(4):e23887. Epub 2022 Apr 6.

Nephrology, St Luke's University Health Network, Easton, USA.

Drug-induced lupus erythematosus (DILE) is a syndrome that manifests with symptoms similar, but with less severity, to that of systemic lupus erythematosus (SLE). Many medications are reported to be involved in DILE; however, terbinafine (Lamisil) is not a well-known causative agent of this syndrome. In this case report, we present a 22-year-old male patient with no prior medical history presented with worsening fever, rash, joint pain, and weight loss a couple of weeks after starting terbinafine. Read More

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An unusual association between anti-histone antibody seropositive SLE, autoimmune hemolytic anemia, and herpetic rash: A case report.

J Family Med Prim Care 2022 Apr 18;11(4):1542-1544. Epub 2022 Mar 18.

Department of Medicine, Tata Main Hospital, Jamshedpur, Jharkhand, India.

Systemic lupus erythematosus (SLE) is an autoimmune disease associated with several autoantibodies targeted to nuclear and cytoplasmic antigens. Positivity of the serum antinuclear antibody (ANA), double stranded (ds) DNA, anti-smith (sm) antibody are essential for the diagnosis of SLE. Anti-histone antibody is usually present in drug-induced SLE. Read More

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Amlodipine-Induced Subacute Cutaneous Lupus Erythematosus Localized to Non-Sun-Exposed Areas.

Case Rep Dermatol 2022 Jan-Apr;14(1):71-76. Epub 2022 Mar 29.

Department of Dermatology, Tokyo Metropolitan Tama Medical Center, Fuchu-shi, Tokyo, Japan.

The cutaneous manifestations of subacute cutaneous lupus erythematosus (SCLE), a subset of cutaneous lupus erythematosus, arise most often in sun-exposed areas. We report a case of SCLE with atypical distribution, following treatment with amlodipine. This highlighted a possible clue that can be used to clinically distinguish a drug-induced case from an idiopathic disorder. Read More

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Clinical use of anti-histone antibodies in idiopathic and drug-induced lupus.

Adrian Y S Lee

Immunol Med 2022 Apr 6:1-6. Epub 2022 Apr 6.

Department of Immunology, Westmead Hospital, Westmead, Australia.

Anti-histone antibodies (AHAs) make their appearance in a number of systemic autoimmune diseases including systemic lupus erythematosus (SLE) and drug-induced lupus erythematosus (DILE). Although being known for over 50 years, they are poorly studied and understood. There is emerging evidence for their use in predicting clinical features of SLE, diversifying their clinical use. Read More

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Acute Pancreatitis After the Use of Belimumab in a Patient With Systemic Lupus Erythematosus: Case Report and Review of Literature.

Cureus 2022 Feb 23;14(2):e22540. Epub 2022 Feb 23.

Rheumatology, Oak Hill Hospital, Spring Hill, USA.

Belimumab is a B-cell depletion therapy that has emerged as an effective and safe treatment option for Systemic Lupus Erythematosus (SLE), but ongoing phase IV trials continue to report its common and rare adverse effects. Our case report seeks to add data to the existing literature on the safety profile of belimumab. We report an interesting and complicated case of a 30-year-old female with a 12-year history of SLE and multiple treatment failures who developed acute pancreatitis in the context of the initiation of belimumab. Read More

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February 2022

Pearls for the diagnosis and possible pathophysiological mechanisms of valproic acid-induced lupus erythematosus: A literature review.

Lupus 2022 May 24;31(6):650-658. Epub 2022 Mar 24.

Pulmonology Department NHS, 37794General Hospital of Thessaloniki "G. Papanikolaou", Thessaloniki, Greece.

Drug-induced lupus erythematosus (DILE) accounts for 10-15% of systemic lupus erythematosus (SLE) cases, with more than 100 pharmaceutical agents implicated in its development. Depending on the offending drug, clinical and serological manifestations present great variability and, thus, DILE may be overlooked in clinical practice. Valproic acid (VPA) - induced lupus erythematosus has not been analytically reported in the literature, rendering the recognition of such cases even more difficult. Read More

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Arerugi 2022 ;71(2):130-134

Department of Respiratory Medicine, Federation of National Public Service and Affiliated Personnel Mutual Aid Associations, Yoshijima Hospital.

A 74-year-old man developed with left pleural effusion and was suspected of benign asbestos pleural effusion and tuberculous pleurisy. Because of elevation of ADA level in the pleural effusion, diagnostic treatment for tuberculous pleurisy by anti-tuberculosis drugs was performed. However, right pleural effusion, cutaneous/mucosal lesions, leukocytopenia, and fever elevation occurred. Read More

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The Immunogenetics of Photodermatoses.

Adv Exp Med Biol 2022 ;1367:369-381

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan.

Photodermatosis is an abnormal skin inflammatory reaction to light. The major classifications of photodermatoses are idiopathic photodermatoses, photodermatoses due to exogenous or endogenous agents, photo-exacerbated dermatoses, and photosensitive genodermatoses. In this chapter, we focus on idiopathic photodermatoses and drug-related photodermatoses and emphasize on the epidemiology and immunogenetic backgrounds. Read More

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Proton Pump Inhibitor Induced Subacute Cutaneous Lupus Erythematosus: A Case Series of 7 Patients and Brief Review of Literature.

Indian Dermatol Online J 2022 Jan-Feb;13(1):64-72. Epub 2022 Jan 24.

Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Background: Subacute cutaneous lupus erythematosus (SCLE) manifests with erythematous, nonscarring, annular, or papulosquamous plaques. Proton pump inhibitors (PPIs) are increasingly being incriminated in its causation, but reports of similar nature from India are lacking.

Aims: To describe the characteristics of seven patients with SCLE induced by PPIs and to review the published cases in order to provide a better perspective of the association. Read More

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January 2022

A Rare Case of Dulaglutide-Associated Angioedema in a Male Patient.

Cureus 2021 Nov 30;13(11):e20041. Epub 2021 Nov 30.

Internal Medicine Department, Primary Health Care Corporation, Athens, GRC.

Dulaglutide is an injectable glucagon-like peptide-1 receptor agonist approved for the treatment of adults with type 2 diabetes. Angioedema is defined as self-limiting edema, localized in the deeper layers of the skin and mucosa. Angioedema can be hereditary or acquired which can be allergic due to reactions to foods, insect bites and stings, and latex, drug-induced, caused by physical stimuli and associated with lupus erythematosus and hypereosinophilia. Read More

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November 2021

Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia.

Cells 2021 12 1;10(12). Epub 2021 Dec 1.

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.

Autoimmune disorders are often associated with low platelet count or thrombocytopenia. In immune-induced thrombocytopenia (IIT), a common mechanism is increased platelet activity, which can have an increased risk of thrombosis. In addition, or alternatively, auto-antibodies suppress platelet formation or augment platelet clearance. Read More

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December 2021

Neuropsychiatric Systemic Lupus Erythematosus in Older Adults: Diagnosis and Management.

Drugs Aging 2022 02 16;39(2):129-142. Epub 2021 Dec 16.

Division of Rheumatology, Department of Medicine, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital-Lupus Clinic, University of Toronto, EW, 1-412, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada.

Systemic lupus erythematosus (SLE) is a multisystem chronic autoimmune disease with variable clinical manifestations. Neuropsychiatric systemic lupus erythematosus (NPSLE) includes the neurologic syndromes of the central, peripheral and autonomic nervous system and the psychiatric syndromes observed in patients with SLE. Neuropsychiatric systemic lupus erythematosus events may present as an initial manifestation of SLE or may be diagnosed later in the course of the disease. Read More

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February 2022

Risk of immunomediated adverse events and loss of response to infliximab in elderly patients with inflammatory bowel disease. A cohort study of the ENEIDA registry.

J Crohns Colitis 2021 Dec 3. Epub 2021 Dec 3.

Hospital Universitario de Burgos, Burgos.

Background: Immunomediated adverse events (IAEs) are the most frequently reported infliximab-related adverse events. Combination therapy may reduce their incidence, although this strategy is not recommended in elderly patients.

Aims: To compare the rates of infliximab-related IAE and loss of response (LOR) in elderly and younger patients. Read More

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December 2021

Causes of Granulomatous Inflammation in Native and Allograft Kidneys: Case Series from A Single Center and A Review of the Literature.

Turk Patoloji Derg 2022 ;38(2):122-132

Division of Nephrology, Muş State Hospital, Muş, TURKEY.

Objective: Granulomatous interstitial nephritis is a rare finding, and etiology differs by geography. We aimed to investigate the distribution of causes of granuloma/granulomata in the kidney and renal survival of these patients in a tertiary care hospital in Western Turkey.

Material And Method: Medical records of adults who underwent a kidney biopsy procedure in our institution between January 2000 and June 2019 were reviewed. Read More

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Use of Colony-Stimulating Factors in Patients With Systemic Lupus Erythematosus.

J Pharm Pract 2021 Nov 8:8971900211053268. Epub 2021 Nov 8.

Department of Pharmaceutical Sciences, 21818Beaumont Hospital, Royal Oak, MI, USA.

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that commonly manifests as cutaneous rashes, renal disease, gastrointestinal dysfunction, and cytopenia. Hematological anomalies are frequently associated with drug-induced toxicity in SLE patients. Colony-stimulating factors have been used to treat drug-induced cytopenia in past case reports; however, evidence suggests that colony-stimulating factors can exacerbate autoimmune disorders, including SLE. Read More

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November 2021

A Case of New-Onset Systemic Lupus Erythematosus With Serositis in a Maintenance Hemodialysis Patient.

Clin Med Insights Case Rep 2021 27;14:11795476211056172. Epub 2021 Oct 27.

Apheresis and Dialysis Center, Keio University School of Medicine, Tokyo, Japan.

A 61-year-old woman with a 4-year history of maintenance hemodialysis due to end-stage renal disease of unknown cause was admitted because of a recurrent fever and abdominal pain lasting for 3 months. She had rheumatoid arthritis as a complication and had taken sulfasalazine for over 4 years. Laboratory data revealed thrombocytopenia, hypocomplementemia, a high C-reactive protein level, and positivity for antinuclear antibody and anti-double strand DNA antibody. Read More

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October 2021

Cutaneous drug-induced lupus erythematosus: Clinical and immunological characteristics and update on new associated drugs.

Ann Dermatol Venereol 2021 Dec 26;148(4):211-220. Epub 2021 Oct 26.

Service de dermatologie et allergologie, faculté de médecine Sorbonne Université, Hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.

Cutaneous drug-induced lupus erythematosus (CDILE) is a lupus-like syndrome related to drug exposure which typically resolves after drug discontinuation. It can present as a systemic or a sole cutaneous form and different drugs may be associated with each form. CDILE pharmacoepidemiology is constantly changing. Read More

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December 2021

Anticoagulant Use as an Independent Risk Factor and Higher In-Hospital Mortality in Patients Showing Alveolar Hemorrhage in Diffuse Lung Disease.

Medicina (Kaunas) 2021 Oct 13;57(10). Epub 2021 Oct 13.

Department of Pathology, Nagoya Tokushukai General Hospital, Kasugai City 487-0016, Japan.

: Bronchoalveolar lavage (BAL) is commonly performed to evaluate diffuse lung disease and occasionally to identify alveolar hemorrhage. However, the clinical impact of alveolar hemorrhage and its risk factors in patients with diffuse lung disease have not been clarified. : We retrospectively analyzed the medical records of all patients who underwent BAL to evaluate diffuse lung disease from January 2017 to December 2020. Read More

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October 2021

A Curious Case of Drug-induced Subacute Cutaneous Lupus Erythematosus.

Indian Dermatol Online J 2021 Sep-Oct;12(5):772-773. Epub 2021 Aug 2.

Department of Pathology, AIIMS, Jodhpur, Rajasthan, India.

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Probable drug-induced lupus erythematosus by zonisamide.

JAAD Case Rep 2021 Nov 14;17:4-6. Epub 2021 Sep 14.

Aesthetic and Clinical Dermatology Associates, Hinsdale, Illinois.

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November 2021

Parkinsonism in viral, paraneoplastic, and autoimmune diseases.

J Neurol Sci 2022 02 1;433:120014. Epub 2021 Oct 1.

Truong Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA; Department of Neurosciences, UC Riverside, Riverside, CA, USA. Electronic address:

Secondary parkinsonism, namely parkinsonism due to causes other than idiopathic neurodegeneration, may have multiple etiologies. Common secondary etiologies of parkinsonism such as drug-induced or vascular etiologies are well documented. Other secondary causes of parkinsonism such as infectious (mainly viral and prion-like diseases), autoimmune (systemic/drug-induced) and paraneoplastic etiologies are rare but are a topic of increasing interest. Read More

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February 2022

Chest high-resolution computed tomography in patients with connective tissue disease: pulmonary conditions beyond "the usual suspects".

Curr Probl Diagn Radiol 2021 Aug 29. Epub 2021 Aug 29.

Institute of Radiology, Department of Medicine, University of Udine, "S. Maria della Misericordia" University Hospital, p.le S. Maria della Misericordia, 15 - 33100 Udine, Italy.

The term "connective tissue diseases" (CTDs) refers to a heterogeneous group of autoimmune disorders, including systemic sclerosis, rheumatoid arthritis, Sjögren's syndrome, systemic lupus erythematosus, polymyositis, dermatomyositis, antisynthetase syndrome, and mixed connective tissue disease. Chest high-resolution computed tomography (HRCT) is the imaging method of choice for evaluating patients with known or suspected CTD-related interstitial lung disease (CTD-ILD), a complication accounting for substantial morbidity and mortality. While specific HRCT patterns and signs of CTD-ILD have been extensively described (hence the designation "the usual suspects"), the knowledge of various, less frequent conditions involving the lungs in patients with CTD would help the radiologist produce a clinically valuable report, thus potentially influencing patient management. Read More

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Levetiracetam-induced systemic lupus erythematosus or simply a drug-induced rash?

Ali S M Jawad

J R Coll Physicians Edinb 2021 Sep;51(3):310-317

Department of Rheumatology, Royal London Hospital, Bancroft Road, London, E1 4DG, UK, Email:

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September 2021

Atypical Subacute Cutaneous Lupus in a Patient on Apixaban Anticoagulation Therapy: A Case Report and Review of the Literature.

Cureus 2021 Jul 22;13(7):e16571. Epub 2021 Jul 22.

Department of Dermatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.

Subacute cutaneous lupus erythematosus (SCLE) is a rare cutaneous lupus erythematosus (CLE) subtype manifesting in middle-aged Caucasians with photo-distributed papulosquamous or annular lesions. Drug-induced SCLE (DI-SCLE) forms present in a similar manner but direct oral anticoagulants are rarely implicated. We report an unusual case of SCLE in a 37-year-old African American patient with a history of unprovoked deep vein thromboses (DVT) who presented with new-onset photoprotected polymorphic lesions two months after the initiation of apixaban anticoagulation therapy. Read More

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Ischemic Choroidal Diseases.

Klin Monbl Augenheilkd 2021 Sep 20;238(9):962-970. Epub 2021 Aug 20.

Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg, Deutschland.

Introduction: Ischemic choroidal diseases are an underdiagnosed entity. The clinical pattern varies according to the size and the localisation of the affected vascular structure.

Clinical Presentation: In eyes with occlusion of the long posterior ciliary arteries, characteristic triangular patches of choroidal ischemia (Amalric sign) are seen, which in the course of time merge into well-defined areas of atrophy of the retinal pigment epithelium. Read More

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September 2021

Adalimumab-Induced Rhupus Syndrome in a Female Patient Affected with Anti-Citrullinated Protein Antibody (ACPA)-Positive Rheumatoid Arthritis (RA): A Case Report and Review of Literature.

Clin Pract 2021 Jul 1;11(3):404-409. Epub 2021 Jul 1.

Primary Care Department, Casa Della Salute "Chiaravalle Centrale", Fragility Outpatient Clinic, Azienda Sanitaria Provinciale di Ca-tanzaro, Chiaravalle, 88064 Catanzaro, Italy.

We report a 38-year-old female patient affected with anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) who developed mild hemolytic anemia (Hb = 10.5 vs. >12 gr/dL), indolent oral ulceration, ANA (1:1280, homogeneous pattern), and anti-dsDNA antibody positivity following 8 months of therapy with an adalimumab biosimilar (GP2017). Read More

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Liver Abnormalities in Systemic Lupus Erythematosus: A Prospective Observational Study.

Cureus 2021 Jun 16;13(6):e15691. Epub 2021 Jun 16.

Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IND.

Objectives In this study, we aimed to examine and analyze liver abnormalities among patients with systemic lupus erythematosus (SLE), including both newly diagnosed patients and those being followed up, as well as the prevalence of lupus hepatitis. Methods This was a prospective observational study. Clinical data, liver function tests (LFTs), and the findings from the ultrasonography of the abdomen among the patients were prospectively recorded and evaluated. Read More

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Clinical and pathophysiological characteristics of valproate-induced pleural effusion.

Clin Toxicol (Phila) 2021 Oct 14;59(10):869-876. Epub 2021 Jul 14.

Experimental Research Center ELPEN, ELPEN Pharmaceuticals, Pikermi, Greece.

Introduction: Valproic acid is a carboxylic acid derivative commonly prescribed for several types of seizure disorders or for acute manic episodes in patients with bipolar disorder. Several cases of valproate-induced pleural effusion have been reported, although the precise pathophysiological mechanism remains unknown.

Objective: To describe the presentation of pleural effusion associated with valproate use and to categorize published case reports according to clinical, immunological, and pleural effusion cell type. Read More

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October 2021