1,005 results match your criteria Lupus Erythematosus Drug-Induced


MMP-9/Gelatinase B Degrades Immune Complexes in Systemic Lupus Erythematosus.

Front Immunol 2019 22;10:538. Epub 2019 Mar 22.

Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Systemic Lupus Erythematosus (SLE) is a common and devastating autoimmune disease, characterized by a dysregulated adaptive immune response against intracellular antigens, which involves both autoreactive T and B cells. In SLE, mainly intracellular autoantigens generate autoantibodies and these assemble into immune complexes and activate the classical pathway of the complement system enhancing inflammation. Matrix metalloproteinase-9 (MMP-9) levels have been investigated in the serum of SLE patients and in control subjects. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440319PMC
March 2019
1 Read

An intriguing case of anemia and renal failure.

Proc (Bayl Univ Med Cent) 2019 Jan 24;32(1):78-79. Epub 2019 Jan 24.

Division of Nephrology, University of Oklahoma-TulsaTulsaOklahoma.

Hydralazine-induced vasculitis is an established autoimmune entity but widely underdiagnosed despite its initial description in 1953. Hydralazine-induced lupus occurs in 5% to 10% of patients and is characterized by fever, arthralgias, rash, anemia, leukopenia, and positive antinuclear antibodies. Renal involvement is rare in drug-induced systemic lupus erythematosus but can occur. Read More

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http://dx.doi.org/10.1080/08998280.2018.1540824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442904PMC
January 2019
1 Read

Acute myocardial infarction and renal dysfunction due to chronic extreme anemia (hemoglobin 2.5 g/dL) in immune thrombocytopenia.

Proc (Bayl Univ Med Cent) 2018 Oct 23;31(4):508-510. Epub 2018 Oct 23.

Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at HoustonHoustonTexas.

Immune thrombocytopenic purpura (ITP) is an acquired thrombocytopenia where autoantibodies are generated against platelet antigens. Primary ITP is often idiopathic, whereas secondary ITP has many potential causes, including drug induced, infection related (human immunodeficiency virus, hepatitis C), leukemias, or autoimmune such as systemic lupus erythematosus. ITP is a common cause of thrombocytopenia in asymptomatic individuals, where evidence of bleeding may be minor or absent. Read More

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http://dx.doi.org/10.1080/08998280.2018.1499317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413974PMC
October 2018
2 Reads

Successful clozapine rechallenge in a patient with suspected drug induced lupus.

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Department of Psychiatry, Welland Centre, Northamptonshire, UK.

Clozapine is the most effective treatment for patients with refractory schizophrenia. Clozapine is also associated with serious and potentially lethal side effects including drug induced lupus (DIL). There have been four previous published case reports describing clozapine inducing a lupus-like syndrome including one previous case where a clozapine rechallenge was attempted without success. Read More

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http://dx.doi.org/10.1136/bcr-2018-228574DOI Listing
April 2019
3 Reads

A Case of Pancytopenia with Many Possible Causes: How Do You Tell Which is the Right One?

Eur J Case Rep Intern Med 2019 30;6(2):001012. Epub 2019 Jan 30.

Department of Internal Medicine, Cascais Hospital, Cascais, Portugal.

Systemic lupus erythematosus (SLE) often presents with cytopenia(s); however, pancytopenia is found less commonly, requiring the consideration of possible aetiologies other than the primary disease. The authors describe the case of a female patient with a recent diagnosis of SLE admitted through the Emergency Department with fever of unknown origin and severe pancytopenia. She was medicated with prednisolone, hydroxychloroquine, azathioprine, amlodipine and sildenafil. Read More

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http://dx.doi.org/10.12890/2019_001012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432823PMC
January 2019
1 Read

Ustekinumab-induced subacute cutaneous lupus.

JAAD Case Rep 2019 Mar 1;5(3):271-273. Epub 2019 Mar 1.

Dermatology Department, University Hospital Limerick, Limerick, Ireland.

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http://dx.doi.org/10.1016/j.jdcr.2019.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403108PMC
March 2019
1 Read

Drug-induced systemic lupus: revisiting the ever-changing spectrum of the disease using the WHO pharmacovigilance database.

Ann Rheum Dis 2019 Apr 4;78(4):504-508. Epub 2019 Feb 4.

AP-HP, Pitié-Salpêtrière Hospital, Department of Pharmacology, Regional Pharmacovigilance Center, INSERM, Sorbonne Universités, Paris, France.

Objective: Drug-induced lupus (DIL) is an idiosyncratic side effect of treatments in which symptoms overlap with those of systemic lupus erythematosus (SLE). The spectrum of DIL constantly evolves with that of the pharmacopoeia. Here, we used VigiBase, the WHO global individual case safety reports (ICSRs) database, to identify the main drugs associated with DIL. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21459
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http://dx.doi.org/10.1136/annrheumdis-2018-214598DOI Listing
April 2019
7 Reads

Are there distinct clinical and pathological features distinguishing Idiopathic from Drug-Induced Subacute Cutaneous Lupus Erythematosus? A European retrospective multicenter study.

J Am Acad Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Dermatology - Department Medical Science and Public Health, University of Cagliari, Via Ospedale 54, 09124 Cagliari Italy; European Academy of Dermatology and Venereology (EADV) Task Force of Dermatopathology; SIDEMAST Dermatopathology Study Group of Italian Society of Dermatology.

Background: Clinical and pathological criteria to distinguish drug-induced subacute lupus erythematosus (DI-SCLE) from idiopathic (I-SCLE) are controversial.

Objective: Aim of the survey was a retrospective analysis of a consistent number of iatrogenous and idiopathic SCLE cases, by means of clinical and histopathological investigation.

Methods: Eleven European University Dermatology Units collected all diagnosed cases from January 2000 to December 2016. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.009DOI Listing
February 2019
3 Reads
4.449 Impact Factor

Intravenous immunoglobulin G use in patients with chronic inflammatory demyelinating polyneuropathy: An uncommon cause of drug-induced discoid lupus erythematosus.

Australas J Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Dermatology, Temple University Hospital, Philadelphia, Pennsylvania, USA.

Drug-induced chronic cutaneous lupus erythematosus, or drug-induced discoid lupus erythematosus, is a rare cutaneous phenomenon. Various medications have been associated with drug-induced discoid lupus erythematosus including fluorouracile agents, especially tegafur and uraciltegafur, and TNF-α antagonists such as infliximab or etanercept. Recent literature has described a case series of six patients receiving IgG immunoglobulin for chronic inflammatory demyelinating polyneuropathy with subsequent presentations of discoid lupus erythematosus. Read More

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http://dx.doi.org/10.1111/ajd.12998DOI Listing
February 2019
2 Reads

[Etiologies and risk factors for young people with intracerebral hemorrhage].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1246-1250

Department of Geriatrics Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To determine the etiologies and risk factors of intracerebral hemorrhage in young people.
 Methods: A total of 401 young patients with intracerebral hemorrhage were enrolled, and they were assigned into a 20-29 , a 30-39, and a 40-45 age group. The differences of various etiologies and risk factors among the three groups were analyzed. Read More

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http://www.csumed.org/xbwk/CN/10.11817/j.issn.1672-7347.2018
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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.11.013DOI Listing
November 2018
11 Reads

Association of raised levels of IL-4 and anti-TPO with hyperprolactinemia.

Am J Reprod Immunol 2019 Mar 30;81(3):e13085. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.

Background And Objective: The modulatory role of prolactin in autoimmune regulation is well established. Hyperprolactinemia is often associated with autoimmune disease like systemic lupus erythematosus and autoimmune thyroid diseases. The objective was to compare levels of direct and indirect autoimmune factors in different categories of hyperprolactinemia cases and predict the direction of association between hyperprolactinemia and autoimmune factors, if any. Read More

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http://dx.doi.org/10.1111/aji.13085DOI Listing
March 2019
4 Reads

When Chest Pain Reveals More: A Case of Hydrochlorothiazide-Induced Systemic Lupus Erythematosus.

Am J Case Rep 2019 Jan 7;20:26-30. Epub 2019 Jan 7.

Department of Internal Medicine, Trihealth Good Samaritan Hospital, Cincinnati, OH, USA.

BACKGROUND Drug induced lupus erythematosus is considered an autoimmune entity which is precipitated by medications. Hydrochlorothiazide has been recognized to cause subacute cutaneous lupus erythematosus, but very few cases of systemic drug induced lupus systemic erythematosus have been reported. CASE REPORT A 57-year-old Caucasian male with a past medical history of hypertension and hyperlipidemia presented with recurrent fevers, chest pain, and dyspnea. Read More

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http://dx.doi.org/10.12659/AJCR.911380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396705PMC
January 2019
3 Reads

INASL Guidelines on Management of Hepatitis B Virus Infection in Patients receiving Chemotherapy, Biologicals, Immunosupressants, or Corticosteroids.

J Clin Exp Hepatol 2018 Dec 26;8(4):403-431. Epub 2018 Jun 26.

Hepatology & Liver Transplant (Medicine), Fortis Escorts Liver & Digestive Diseases Institute (FELDI), Fortis Escorts Hospital, Delhi, India.

Hepatitis B Virus (HBV) reactivation in patients receiving chemotherapy, biologicals, immunosupressants, or corticosteroids is emerging to be an important cause of morbidity and mortality in patients with current or prior exposure to HBV infection. These patients suffer a dual onslaught of illness: one from the primary disease for which they are receiving the culprit drug that led to HBV reactivation, and the other from HBV reactivation itself. The HBV reactivation not only leads to a compromised liver function, which may culminate into hepatic failure; it also adversely impacts the treatment outcome of the primary illness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09736883183009
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http://dx.doi.org/10.1016/j.jceh.2018.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286881PMC
December 2018
34 Reads

Lamotrigine-induced Systemic Lupus Erythematosus: A Diagnostic Dilemma.

Indian Dermatol Online J 2018 Nov-Dec;9(6):445-447

Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Many drugs are known to cause systemic lupus erythematosus (SLE), however there are no well defined criteria for drug induced lupus erythematosus (DILE). We present a rare case of lamotrigine induced lupus presenting as acute syndrome of apoptotic pan epidermolysis (ASAP). Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_24_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232978PMC
December 2018
2 Reads

Reprint of "The interaction between environmental triggers and epigenetics in autoimmunity".

Authors:
Bruce Richardson

Clin Immunol 2018 Nov 30;196:72-76. Epub 2018 Nov 30.

Department of Internal Medicine, Division of Rheumatology, University of Michigan, SRB 3007, 109 Zina Pitcher Pl., Ann Arbor, MI 48109-2200, United States. Electronic address:

Systemic lupus erythematosus flares when genetically predisposed people encounter environmental agents that cause oxidative stress, such as infections and sunlight. How these modify the immune system to initiate flares is unclear. Drug induced lupus models demonstrate that CD4+ T cells epigenetically altered with DNA methylation inhibitors cause lupus in animal models, and similar T cells are found in patients with active lupus. Read More

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http://dx.doi.org/10.1016/j.clim.2018.11.013DOI Listing
November 2018
2 Reads

Diagnostic biologique des angioedèmes bradykiniques : les recommandations du CREAK.

Presse Med 2019 Jan 8;48(1 Pt 1):55-62. Epub 2018 Nov 8.

Centre de référence national des angioedèmes (CREAK), 38043 Grenoble, France; Service d'immunologie, CHUGA, 38043 Grenoble, France.

Bradykinin mediated angioedema (BK-AE) can be associated either with C1Inhibitor deficiency (hereditary and acquired forms), either with normal C1Inh (hereditary form and drug induced AE as angiotensin converting enzyme inhibitors…). In case of high clinical suspicion of BK-AE, C1Inh exploration must be done at first: C1Inh function and antigenemy as well as C4 concentration. C1Inh deficiency is significant if the tests are below 50 % of the normal values and controlled a second time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07554982183032
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http://dx.doi.org/10.1016/j.lpm.2018.06.015DOI Listing
January 2019
9 Reads

Alveolar Hemorrhage in Vasculitis (Primary and Secondary).

Semin Respir Crit Care Med 2018 08 7;39(4):482-493. Epub 2018 Nov 7.

Department of Respiratory Medicine, Hospices Civils de Lyon, National Reference Center for Rare Pulmonary Diseases, Lyon, France.

Defined by the accumulation of red blood cells into the alveolar space, diffuse alveolar hemorrhage (DAH) is a severe and potentially fatal medical condition requiring careful attention. In contrast to simple extravasation of erythrocytes facilitated by impaired hemostasis or hemodynamic causes, DAH in vasculitis is due to capillaritis, that is, inflammation of capillaries. Dyspnea, hemoptysis, chest infiltrates, and abrupt fall of blood hemoglobin level represent the cardinal features of DAH; yet, hemoptysis is lacking in one-third of cases. Read More

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http://dx.doi.org/10.1055/s-0038-1668533DOI Listing
August 2018
22 Reads

[When drugs induce cutaneous lupus erythematosus].

Ugeskr Laeger 2018 Oct;180(41)

Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is defined as an adverse reaction to continuous use of a culprit drug. The reaction resolves upon drug withdrawal. More than 50 drugs have been linked to DI-SCLE, and it is estimated, that around 20% of the SCLE cases are drug-induced. Read More

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October 2018
5 Reads

Drug-Induced Cutaneous Lupus Erythematosus: A Case Series of Five Patients with Bupropion-Associated Disease.

J Clin Rheumatol 2018 Sep 14. Epub 2018 Sep 14.

University of Iowa Carver College of Medicine Vujevich Dermatology AssociatesWashington, PA Departments of Dermatology and Pathology University of Iowa Hospitals and Clinics Department of Dermatology Iowa City VA Medical Center Department of Dermatology University of Iowa Hospitals and Clinics Department of Dermatology Iowa City VA Medical Center

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http://dx.doi.org/10.1097/RHU.0000000000000882DOI Listing
September 2018

Frequency of Pathologic Changes in the Oral Cavity in Patients Subjected to Long-term Pharmacologic Immunosuppressive Therapy After Kidney, Liver, and Hematopoietic Cell Transplantation.

Transplant Proc 2018 Sep 11;50(7):2176-2178. Epub 2018 Apr 11.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

Introduction: Patients subjected to long-term immunosuppressive therapy after organ and cells transplantation are more susceptible than healthy people to the development of the pathologic changes in the oral cavity, including precancerous lesions, oral cancers, lesions following viral infections (herpes simplex virus, Epstein-Barr virus, and cytomegalovirus), fungal infections mainly caused by Candida albicans, drug-induced gingival overgrowth, stomatitis, and tongue disorders.

Material And Methods: Clinical case material included 38 patients after kidney, liver, or blood-forming cells transplantation subjected to various immunosuppressive therapy schemes. The study comprised standard case taking and physical examination of the patient, including detailed intraoral and extraoral stomatological examinations. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.003DOI Listing
September 2018
16 Reads

Subacute cutaneous lupus erythematosus and systemic lupus erythematosus associated with abatacept.

JAAD Case Rep 2018 Aug 16;4(7):698-700. Epub 2018 Aug 16.

Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jdcr.2018.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113658PMC
August 2018
3 Reads

Delayed Diagnosis of Tuberculoma in a Child with Nephritis due to Systemic Lupus Erythematosus.

Turk Thorac J 2018 Jul 19;19(3):153-155. Epub 2018 Jun 19.

Department of Child Health, Padjadjaran University School of Medicine, Hasan Sadikin General Hospital, Bandung, Indonesia.

Tuberculoma is one of the manifestations of tuberculosis infection in the central nervous system. Even though its prevalence is only 1%, the mortality rate is high. Clinical presentation in immunocompromised patients with tuberculoma maybe different, thus making the diagnosis difficult. Read More

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http://dx.doi.org/10.5152/TurkThoracJ.2018.17033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077006PMC
July 2018
23 Reads

Antinuclear antibody-negative lupus? An ominous presentation of hydralazine-induced lupus syndrome.

Eur J Rheumatol 2018 Dec 20;5(4):272-274. Epub 2018 Jun 20.

Department of Cardiovascular Science, East Carolina University East Carolina Heart Institute, Greenville, North Carolina, USA.

Up to 10% of systemic lupus erythematosus (SLE) cases are drug-induced; hence, they are called drug-induced lupus syndrome (DILS). Antinuclear antibody (ANA) should be present to diagnose SLE and DILS. ANA-negative lupus is very rare; therefore, it presents a diagnostic challenge. Read More

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http://dx.doi.org/10.5152/eurjrheum.2018.18040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267758PMC
December 2018
2 Reads

Drug-induced lupus: Traditional and new concepts.

Autoimmun Rev 2018 Sep 10;17(9):912-918. Epub 2018 Jul 10.

Nephrology Unit, Fondazione Ca' Granda IRCCS Ospedale Maggiore, Milano, Italy.

Drug-induced lupus (DIL) includes a spectrum of drug-induced reactions often characterised by a clinical phenotype similar to that of idiopathic systemic lupus eruthematosus (SLE) but usually lacking major SLE complications. Different drugs may be associated with distinct clinical and serological profiles, and early recognition is crucial. Drugs traditionally associated with DIL include procainamide, hydralazine, quinidine and others, but strong associations with newer agents, such as TNF α (TNFα) inhibitors, are increasingly recognised. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.03.016DOI Listing
September 2018
24 Reads

Recent Developments in the Diagnosis and Management of Photosensitive Disorders.

Am J Clin Dermatol 2018 Oct;19(5):707-731

Department of Dermatology, Henry Ford Hospital, 3031 West Grand Blvd, Suite 800, Detroit, MI, 48202, USA.

Photodermatoses occur in males and females of all races and ages. Onset can be variable in timing and influenced by genetic and environmental factors. Photodermatoses are broadly classified as immunologically mediated, chemical- and drug-induced, photoaggravated, and genetic (defective DNA repair or chromosomal instability) diseases. Read More

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http://dx.doi.org/10.1007/s40257-018-0365-6DOI Listing
October 2018
14 Reads

Response to: 'Drug-induced lupus erythematosus following immunotherapy with anti-programmed death-(ligand) 1' by Michot .

Ann Rheum Dis 2018 Jun 22. Epub 2018 Jun 22.

Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France.

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http://dx.doi.org/10.1136/annrheumdis-2018-213691DOI Listing
June 2018
2 Reads

Stevens-Johnsons syndrome or drug-induced lupus - a clinical dilemma: A case report and review of the literature.

Biomed Rep 2018 Jul 16;9(1):37-41. Epub 2018 May 16.

Department of Internal Medicine and Rheumatology, 'Sfanta Maria' Hospital, 011172 Bucharest, Romania.

Tumor necrosis factor inhibitors are the first biological agents used in the treatment of rheumatoid arthritis (RA) to have yielded satisfactory results in terms of clinical improvement and radiologic progression, but they are also associated with the possibility of occurrence of a number of autoimmune systemic events [drug-induced lupus (DIL), vasculitis, sarcoidosis] and localized adverse events [uveitis, psoriasis, interstitial lung disease, erythema multiforme including the major form Stevens-Johnson syndrome (SJS)]. During treatment with TNF inhibitors, many patients develop positivity for antinuclear, antihistone and anti-double stranded DNA antibodies, though only a minority of patients will develop clinical manifestations and approximately less than 1% will fulfill the classification criteria for systemic lupus erythematosus. Mucocutaneous manifestations are the most frequent manifestations of DIL following treatment with TNF inhibitors, and can be severe and occasionally difficult to differentiate from erythema multiforme/SJS. Read More

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http://www.spandidos-publications.com/10.3892/br.2018.1098
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http://dx.doi.org/10.3892/br.2018.1098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007037PMC
July 2018
11 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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http://doi.wiley.com/10.1002/JPER.17-0719
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http://dx.doi.org/10.1002/JPER.17-0719DOI Listing
June 2018
42 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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http://dx.doi.org/10.1111/jcpe.12940DOI Listing
June 2018
66 Reads

Prevalence of antinuclear antibodies in hidradenitis suppurativa.

Int J Rheum Dis 2018 May;21(5):1018-1022

Division of Rheumatology, School of Medicine and Health Sciences, Ideas to Health Laboratory, The George Washington University, Washington, District of Columbia, USA.

Aim: The purpose of this study was to investigate the prevalence of antinuclear antibody (ANA) positivity in a cohort of patients with hidradenitis suppurativa (HS), and to assess the frequency of seroconversion during treatment with tumor necrosis factor (TNF)-α inhibitor therapy.

Methods: This prospective study was conducted through the Wound Etiology and Healing (WE-HEAL) Study. Immunofluorescence ANA testing was performed at baseline, and repeated when clinically indicated. Read More

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http://dx.doi.org/10.1111/1756-185X.13312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995150PMC
May 2018
27 Reads

Drug-induced lupus erythematosus: an update on drugs and mechanisms.

Authors:
Ye He Amr H Sawalha

Curr Opin Rheumatol 2018 Sep;30(5):490-497

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Purpose Of Review: Rapid introduction of newly developed drugs in the absence of clear understanding of the pathophysiologic mechanisms behind drug-induced lupus erythematosus (DILE) can sometimes make DILE difficult to recognize in clinical practice. The purpose of this review is to summarize drugs most recently reported to be involved in DILE and discuss the current landscape of diverse mechanisms involved.

Recent Findings: A large number of proton pump inhibitor (PPI)-induced subacute cutaneous lupus erythematosus cases have been reported, suggesting a shift over time in the spectrum of drugs implicated in DILE. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000522DOI Listing
September 2018
3 Reads

Clindamycin-induced Maculopapular Exanthema with Preferential Involvement of Striae Distensae: A Koebner phenomenon?

Acta Dermatovenerol Croat 2018 Apr;26(1):61-63

Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;

Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

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April 2018
23 Reads

Drug-induced Subacute Cutaneous Lupus Erythematosus Caused by a Topical Beta Blocker - Timolol.

Acta Dermatovenerol Croat 2018 Apr;26(1):44-47

Monika Bilewicz-Stebel, MD Department of Internal Medicine, Dermatology and Allergology, Curie-Skłodowskiej 10, 41-800 Zabrze, Poland, School of Public Health Medical University of Silesia in Katowice 40-027 Katowice, Poland;

Drug-induced lupus erythematosus (DI-LE) is an autoimmune condition secondary to a recent pharmacological intervention. There are no established specific diagnostic criteria for DI-LE, and the disease is recognized based on the medical history of the patient. Typically, the onset is closely related to a recent drug exposure, and the disease terminates after discontinuation of the inducing factor. Read More

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April 2018
15 Reads

Bone marrow as a target organ of systemic lupus erythematosus: analysis of cases with myelofibrosis.

Int J Rheum Dis 2018 May 19;21(5):1049-1059. Epub 2018 Apr 19.

Division of Rheumatology, Department of Internal Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey.

Aim: Cytopenia in the course of systemic lupus erythematosus (SLE) may be due to multiple factors. In this study, we aimed primarily to evaluate the detailed results of bone marrow (BM) biopsies of SLE patients, secondly to determine the myelofibrosis (MF) frequency and thirdly to compare BM morphologic findings as well as the clinical and laboratory parameters between groups (with MF and without MF) in cytopenic SLE patients.

Methods: We retrospectively analyzed 224 SLE patients' files. Read More

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http://dx.doi.org/10.1111/1756-185X.13308DOI Listing
May 2018
2 Reads

Rare case of chorea-hyperglycaemia-basal ganglia (C-H-BG) syndrome.

BMJ Case Rep 2018 Apr 17;2018. Epub 2018 Apr 17.

Department of Diabetes and Endocrinology, University Hospital Llandough, Llandough, UK.

An 83-year-old woman presented with acute-onset haemichorea and haemiballism particularly affecting the left side of the body. She was known to have type 2 diabetes, which was poorly controlled with sitagliptin. She was hyperglycaemic but not ketotic or acidotic. Read More

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http://dx.doi.org/10.1136/bcr-2017-223920DOI Listing
April 2018
3 Reads

The interaction between environmental triggers and epigenetics in autoimmunity.

Authors:
Bruce Richardson

Clin Immunol 2018 Jul 9;192:1-5. Epub 2018 Apr 9.

Department of Internal Medicine, Division of Rheumatology, University of Michigan, SRB 3007, 109 Zina Pitcher Pl., Ann Arbor, MI 48109-2200, United States. Electronic address:

Systemic lupus erythematosus flares when genetically predisposed people encounter environmental agents that cause oxidative stress, such as infections and sunlight. How these modify the immune system to initiate flares is unclear. Drug induced lupus models demonstrate that CD4+ T cells epigenetically altered with DNA methylation inhibitors cause lupus in animal models, and similar T cells are found in patients with active lupus. Read More

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http://dx.doi.org/10.1016/j.clim.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988979PMC
July 2018
1 Read

The devil's in the dosing: severe drug-induced liver injury in a hydroxychloroquine-naive patient with subacute cutaneous lupus erythematosus and porphyria cutanea tarda.

Lupus 2018 Jul 9;27(8):1383-1386. Epub 2018 Apr 9.

1 Division of Rheumatology, University of Michigan Medical School, USA.

A 29-year-old woman with a 1.5 year history of photosensitive skin lesions on her hands presented with a malar rash, bullous lesions on her hands, and was diagnosed with subacute lupus erythematosus after serologies revealed a positive antinuclear antibody test (1:2560), and antibodies to Ro/SSA and dsDNA. Hydroxychloroquine (400 mg/day) was prescribed and the patient developed severe drug-induced liver injury. Read More

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http://dx.doi.org/10.1177/0961203318768884DOI Listing
July 2018
6 Reads

Hydralazine-associated vasculitis: Overlapping features of drug-induced lupus and vasculitis.

Semin Arthritis Rheum 2018 10 12;48(2):283-287. Epub 2018 Jan 12.

Division of Immunology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242.

Introduction: Hydralazine is an antihypertensive medication that has been associated with drug-induced lupus erythematosus (DIL) as well as ANCA-associated vasculitis (AAV). Although rare, early diagnosis is critical since drug cessation is the mainstay of therapy. This retrospective study aims to characterize the clinical, laboratory, and histopathologic features of this disease. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.01.005DOI Listing
October 2018
6 Reads

Drug-induced Rowell syndrome, a rare and difficult to manage disease: A case report.

Exp Ther Med 2018 Jan 23;15(1):785-788. Epub 2017 Nov 23.

Department of Ophthalmology, Grigore T. Popa University of Medicine and Pharmacy, 700715 Iași, Romania.

Rowell syndrome is defined as the association between lupus erythematosus, erythema multiforme-like lesions and characteristic immunological changes including positive tests for rheumatoid factor, speckled antinuclear antibody, positive anti-Ro or anti-La antibodies. The present report presents the case of a 45-year-old female patient who was previously diagnosed in January 2010 with terbinafine-induced subacute cutaneous lupus erythematosus and was admitted for a skin eruption consisting of erythematous-papular erythema multiforme-like lesions, primarily on the trunk and limbs. The associated symptoms consisted of fatigability, myalgia and gonalgia. Read More

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http://dx.doi.org/10.3892/etm.2017.5557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777104PMC
January 2018
24 Reads

ANA-Negative Hydralazine-Induced Pericardial Effusion.

Case Rep Med 2017 17;2017:3521541. Epub 2017 Dec 17.

Department of Cardiology, Maricopa Integrated Health System, Phoenix, AZ, USA.

This case describes a patient with pericardial effusion as a phenomenon of the drug-induced lupus erythematosus (DILE) syndrome due to hydralazine. The relevance of this case report lies in the fact that although hydralazine has been a known causative agent of DILE, its presentation may involve a negative anti-nuclear antibody (ANA) study. Pericardial effusion is a documented adverse effect as a result of hydralazine use. Read More

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http://dx.doi.org/10.1155/2017/3521541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748098PMC
December 2017
3 Reads

Drug-induced aseptic meningitis: a mini-review.

Fundam Clin Pharmacol 2018 Jun 9;32(3):252-260. Epub 2018 Mar 9.

Centre Régional de Pharmacovigilance, CHRU de Nancy, Hôpital Central, 29, avenue du Maréchal de Lattre de Tassigny, 60034, 54035, Nancy, France.

Aseptic meningitis associates a typical clinical picture of meningitis with the absence of bacterial or fungal material in the cerebrospinal fluid. Drug-induced aseptic meningitis (DIAM) may be due to two mechanisms: (i) a direct meningeal irritation caused by the intrathecal administration of drugs and (ii) an immunologic hypersensitivity reaction to a systemic administration. If the direct meningeal irritation allows a rather easy recognition, the immunologic hypersensitivity reaction is a source of challenging diagnostics. Read More

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http://dx.doi.org/10.1111/fcp.12349DOI Listing
June 2018
7 Reads

Drug-induced lupus erythematosus secondary to pirfenidone.

Br J Dermatol 2018 06 6;178(6):1437-1438. Epub 2018 Apr 6.

Dermatology Department, St. Vincent's University Hospital, Elm Park, Dublin 4, Dublin, Ireland.

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http://dx.doi.org/10.1111/bjd.16246DOI Listing
June 2018
2 Reads

Drug-Induced by Systemic Lupus Erythematosus Presenting as Recurrent Pericardial Effusion After Mitral Valve Repair.

Acta Med Iran 2017 Sep;55(9):597-601

Department of Cardiac Surgery, Imam Ali Hospital, Kermanshah University of Medicine, Kermanshah, Iran.

We report a patient presented with recurrent pericardial effusion caused by drug-induced systemic lupus Erythematosus (SLE) following mitral valve repair. The surgery was complicated by hemiparesis and convulsion in early postoperative period. The patient had been received carbamazepine for a paroxysmal seizure that occurred following mitral valve repair. Read More

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September 2017
6 Reads

[Esomeprazol-induced cutaneous lupus erythematosus].

Z Gastroenterol 2017 Sep 12;55(9):861-865. Epub 2017 Sep 12.

Klinik für Gastroenterologie und gastrointestinale Onkologie, Georg-August-Universität Göttingen Universitätsmedizin, Göttingen, Germany.

Proton pump inhibitors are among the most commonly used drugs worldwide. They are considered to be largely safe and cause little side-effects. We report a 69-year-old woman who suffered from erythematous plaques 2 months after initiating therapy with esomeprazole. Read More

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http://dx.doi.org/10.1055/s-0043-113833DOI Listing
September 2017
3 Reads

Drug-Induced Lupus Erythematosus Associated with Antiretroviral Therapy in a Patient with Human Immunodeficiency Virus: A Case Report.

Cureus 2017 Sep 7;9(9):e1661. Epub 2017 Sep 7.

Rheumatology, Mount Sinai Icahn School of Medicine Queens Hospital New York.

Antiretroviral medications are the mainstay of human immunodeficiency virus (HIV) therapy and some have been in use for over 20 years. To date, there have been no reported cases of antiretroviral therapy (ART) induced drug-induced lupus erythematosus (DILE). We present a case of a 35-year-old woman who received a combination of emtricitabine, rilpivirine, and tenofovir disoproxil fumarate for HIV treatment. Read More

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http://dx.doi.org/10.7759/cureus.1661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675601PMC
September 2017
2 Reads

[Secukinumab-induced subacute-cutaneous lupus erythematosus].

Hautarzt 2018 Jan;69(1):64-66

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Deutschland.

We report about a 52-year-old woman with onset of drug-induced lupus erythematosus (DILE) in sun-exposed areas, under therapy with secukinumab. Topical therapy with a steroid class 3 for 4 weeks showed substantial improvement. The systemic therapy was switched to ustekinumab. Read More

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http://dx.doi.org/10.1007/s00105-017-4071-8DOI Listing
January 2018
3 Reads

Diverse patterns of anti-TNF-α-induced lupus: case series and review of the literature.

Clin Rheumatol 2018 Feb 23;37(2):563-568. Epub 2017 Oct 23.

Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel.

The induction of autoantibodies is common following therapy with anti-TNF-α agents. However, anti-TNF-α-induced lupus (ATIL) is rare. We assessed the clinical characteristics of three patients with inflammatory bowel disease (IBD) who were treated with infliximab and developed distinct subsets of ATIL. Read More

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http://dx.doi.org/10.1007/s10067-017-3884-2DOI Listing
February 2018
31 Reads

Neutrophil extracellular traps in vasculitis, friend or foe?

Curr Opin Rheumatol 2018 Jan;30(1):16-23

Department of Medical and Health Sciences.

Purpose Of Review: Neutrophil extracellular traps (NETs) can be found at the sites of vascular lesions and in the circulation of patients with active small vessel vasculitis. Neutrophils from vasculitis patients release more NETs in vitro, and NETs have properties that can harm the vasculature both directly and indirectly. There are several ways to interfere with NET formation, which open for new therapeutic options. Read More

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http://Insights.ovid.com/crossref?an=00002281-201801000-0000
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http://dx.doi.org/10.1097/BOR.0000000000000450DOI Listing
January 2018
6 Reads

Drug-induced Lupus Presenting with Myocarditis.

J Assoc Physicians India 2017 Jun;65(6):110

RMO, Chittaranjan Seva Sadan, Kolkata, West Bengal.

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June 2017
10 Reads