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    Eruptive Keratoacanthoma-Like Discoid Lupus Erythematosus.
    Am J Dermatopathol 2017 Aug 9. Epub 2017 Aug 9.
    Departments of *Dermatology, and †Pathology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY.
    Hypertrophic discoid lupus erythematosus can resemble keratoacanthoma histomorphologically. We describe a unique case of eruptive keratoacanthomatous scaly papules in a 56-year-old woman with discoid lupus erythematosus. We review the literature and conclude by discussing important histologic features and useful immunostains to consider when attempting to discern the underlying identity and pathogenicity of such lesions. Read More

    Elastic Staining in Differentiating Between Follicular Streamers and Follicular Scars in Horizontal Scalp Biopsy Sections.
    Am J Dermatopathol 2017 Aug 9. Epub 2017 Aug 9.
    Departments of *Pathology, and †Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL; and ‡Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.
    Background: Accurate identification of follicular streamers versus follicular scars on horizontal scalp biopsy sections is important to differentiate between cicatricial and noncicatricial alopecias. However, distinguishing between them can be difficult especially in nonoptimal specimens. The utility of elastic Verhoeff-Van Gieson (EVG) stain in cicatricial alopecias has been described on vertical sections, but its evaluation on horizontal sections has not been performed. Read More

    Direct antiglobulin (Coombs) test in systemic lupus erythematosus patients.
    Clin Rheumatol 2017 Jul 31. Epub 2017 Jul 31.
    Medicine Department, Evangelic University, R. Padre Agostinho, 2770, Curitiba, Paraná, 80730-000, Brazil.
    The objective of the study is to study the positivity of Coombs test or direct antiglobulin test (DAT) in systemic lupus erythematosus (SLE) patients and its relationship with disease's clinical and serological profile. Retrospective study of 373 SLE patients seen at single Rheumatology Unit. Epidemiological data (age, gender, age at disease onset, auto declared ethnic background and tobacco use), clinical (malar rash, photosensitivity, oral ulcers, discoid lesions, serositis, glomerulonephritis, convulsions, psychosis, hemolytic anemia, leukopenia, lymphocytopenia and arthritis), and serological profile (anti ds DNA, anti Ro/SS-A; anti La/SS-B, Anti RNP, Anti Sm, aCl (anticardiolipin) IgG, aCl Ig M, LA or lupus anticoagulant, rheumatoid factor and direct Coombs) were collected. Read More

    The Cutaneous Spectrum of Lupus Erythematosus.
    Clin Rev Allergy Immunol 2017 Jul 27. Epub 2017 Jul 27.
    Dermatologic Clinic, Faculty of Medicine, University of Strasbourg, Strasbourg, France.
    Systemic lupus erythematosus is a complex autoimmune disease with a wide spectrum of clinical and immunopathological features. Cutaneous and articular manifestations are the most common signs in patients with systemic lupus erythematosus. We here review the pathogenesis and the new classification of cutaneous lupus erythemathosus with a discussion of the significance of the various cutaneous signs. Read More

    Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma.
    Skinmed 2017 1;15(3):218-220. Epub 2017 Jun 1.
    Department of Dermatology, Mayo Clinic, Rochester, MN.
    A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs. Read More

    Reflectance confocal microscopic evaluation of nonmelanocytic lip lesions.
    Lasers Med Sci 2017 Jul 5. Epub 2017 Jul 5.
    Department of Dermatology, Süleymaniye Gynecology and Maternity Training and Research Hospital, İstanbul, Turkey.
    Lips display various benign and malignant lesions. Considering their functional and cosmetic importance, noninvasive diagnostic methods are required. In vivo reflectance confocal microscopy (RCM) has already been reported to be useful in the evaluation of various skin lesions. Read More

    Genetic similarities and differences between discoid and systemic lupus erythematosus patients within the Polish population.
    Postepy Dermatol Alergol 2017 Jun 29;34(3):228-232. Epub 2017 May 29.
    Division of Molecular and Forensic Genetics, Department of Forensic Medicine, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
    Introduction: Many studies have shown that some SNPs might be a risk factor for systemic lupus erythematosus (SLE), but little is known about potential susceptibility loci of the skin types of the disease. Discoid lupus erythematosus (DLE) is the most common form of the cutaneous lupus erythematosus. Nevertheless, a genetic contribution to DLE is not fully recognized. Read More

    Diagnostic value of immunohistochemistry staining of Bcl-2, CD34, CD20 and CD3 for distinction between discoid lupus erythematosus and lichen planus in the skin.
    Indian J Pathol Microbiol 2017 Apr-Jun;60(2):172-176
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    Background: Cluster of differentiation (CD) markers is a classification system for monoclonal antibodies against cell surface molecules on leukocytes and antigens from other cells.

    Aims: The aim of this study is to evaluate immunohistochemical markers in patients with discoid lupus erythematosus (DLE) and lichen planus (LP) and correlation of these markers in two groups and with the normal group in the West of Iran.

    Settings And Design: Analytical cross-sectional study. Read More

    Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome.
    Intern Med 2017 15;56(12):1581-1583. Epub 2017 Jun 15.
    Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan.
    A 35-year-old woman with discoid lupus erythematosus (DLE) was admitted at 11 weeks' gestation with a persistent fever. Laboratory studies revealed pancytopenia, elevated liver enzymes, and hyperferritinemia. Bone marrow aspiration confirmed the diagnosis of hemophagocytic syndrome (HPS). Read More

    Histologic features of chronic cutaneous lupus erythematosus of the scalp using horizontal sectioning: Emphasis on follicular findings.
    J Am Acad Dermatol 2017 Aug 16;77(2):349-355. Epub 2017 Jun 16.
    Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address:
    Background: Chronic cutaneous lupus erythematosus (CCLE) often affects the scalp resulting in scarring alopecia. While histopathologic findings of CCLE have been well described, there is little written on the morphologic changes to the hair follicles in this condition.

    Objective: We aim to determine the histopathologic findings of hair follicles in CCLE of the scalp. Read More

    Development of classification criteria for discoid lupus erythematosus: Results of a Delphi exercise.
    J Am Acad Dermatol 2017 Aug 9;77(2):261-267. Epub 2017 Jun 9.
    Harvard Medical School, Boston, Massachusetts; Division of Rheumatology, Departments of Dermatology and Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:
    Background: No classification criteria currently exist for discoid lupus erythematosus (DLE), which has led to problematic heterogeneity in both observational and interventional research efforts.

    Objectives: We sought to develop DLE classification criteria based on consensus of international expert opinion of relevant stakeholders in the field.

    Methods: Using a Delphi consensus process and nominal group techniques, potential items for classification criteria were generated. Read More

    Effect of ethnicity on clinical presentation and risk of antiphospholipid syndrome in Roma and Caucasian patients with systemic lupus erythematosus: a multicenter cross-sectional study.
    Int J Rheum Dis 2017 Jun 7. Epub 2017 Jun 7.
    Department of Internal Medicine, Complejo Hospitalario Universitario de Granada, Granada, Spain.
    Aim: To determine if there are ethnic differences in the prevalence of antiphospholipid syndrome (APS), clinical presentation and autoantibody profile between Roma and Caucasian patients with systemic lupus erythematosus (SLE).

    Method: A cross-sectional study was conducted including data from Roma and Caucasian SLE patients consecutively attending six hospitals in Spain. Socio-demographic characteristics, prevalence of APS, clinical and analytical features of SLE and APS were compared between ethnic groups. Read More

    Intense Pulsed Light and Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment for the Scarring Lesion of Discoid Lupus Erythematosus.
    Ann Dermatol 2017 Jun 11;29(3):331-333. Epub 2017 May 11.
    Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
    Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus that can cause permanent scarring. Treatment of DLE includes protection from sunlight and artificial sources of ultraviolet light, as well as systemic and topical medications. The first-line standard therapies are antimalarials and topical steroids. Read More

    The Increased Expression of Toll-Like Receptor 4 in Renal and Skin Lesions in Lupus Erythematosus.
    J Histochem Cytochem 2017 Jul 22;65(7):389-398. Epub 2017 May 22.
    Immunology Department, Habib Bourguiba Hospital (NE, RF, OA, MBJ, HM), University of Sfax, Sfax, Tunisia.
    Toll-like receptor 4 (TLR-4), a bacterial lipopolysaccharide sensor, is an innate immunity essential modulator. It is expressed on both immune and non-immune cells and may contribute to the cutaneous and renal manifestations during lupus erythematosus (LE). Our purpose is to evaluate TLR-4 expression and analyzing its role in lupus nephritis (LN) and chronic cutaneous lupus erythematosus (CLE) pathogenesis. Read More

    Anti-glomerular basement membrane disease accompanied by systemic lupus erythematosus presenting central nervous system involvement.
    CEN Case Rep 2017 May 27;6(1):1-4. Epub 2016 Aug 27.
    Hokkaido Renal Pathology Center, Sapporo IT Front Building #196 N9 W15, Chuo-ku, Sapporo, Hokkaido, 0600009, Japan.
    We report a case of rapidly progressive glomerulonephritis caused by anti-glomerular basement membrane (GBM) disease accompanied by systemic lupus erythematosus (SLE) presenting central nervous system involvement in a 32-year-old Japanese male. He was admitted to our hospital because of a 3-week history of fever and rapidly failing renal function requiring hemodialysis (HD). Laboratory tests showed anti-GBM antibody elevation with a value of 16,385 units/ml. Read More

    Classifying discoid lupus erythematosus: background, gaps, and difficulties.
    Int J Womens Dermatol 2017 Mar 16;3(1 Suppl):S62-S66. Epub 2017 Feb 16.
    Corporal Michael J. Crescenz VAMC (Philadelphia), Philadelphia, PA.
    To inform our ongoing efforts to develop defining features to be incorporated into a novel set of classification criteria for discoid lupus erythematosus (DLE), we conducted a literature review using the Ovid MEDLINE database. A search was performed to identify studies reporting criteria used to distinguish DLE from other cutaneous lupus erythematosus subtypes. We examined which clinical, histopathologic, and serologic features have data to support their use as effective features in distinguishing DLE from other potential disease mimickers and cutaneous lupus subsets. Read More

    Pathogenesis of cutaneous lupus erythema associated with and without systemic lupus erythema.
    Autoimmun Rev 2017 Jul 5;16(7):735-742. Epub 2017 May 5.
    Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address:
    Cutaneous lupus erythematosus (CLE) can be an individual disease only involving skin, or presents as part of the manifestations of SLE. A small proportion of CLE may progress into SLE, however, the underlying pathogenic mediators remain elusive. By only including researches that clearly described if the subtypes of CLE presented by enrolled subjects was associated with or without SLE, we provided an overview of antibodies, inflammatory cells and inflammatory molecular mediators identified in blood and skin that were possibly involved in lupus skin damages. Read More

    Clinical and immunological characteristics of 150 systemic lupus erythematosus patients in Jamaica: a comparative analysis.
    Lupus 2017 Jan 1:961203317707828. Epub 2017 Jan 1.
    1 Department of Medicine, University of the West Indies, Mona, Jamaica.
    Background Epidemiological studies in systemic lupus erythematosus have been reported in the literature in many countries and ethnic groups. Although systemic lupus erythematosus in Jamaica has been described in the past, there has not been a detailed evaluation of systemic lupus erythematosus patients in urban Jamaica, a largely Afro-Caribbean population. The goal of this study was to describe the clinical features, particularly disease activity, damage index and immunological features, of 150 systemic lupus erythematosus subjects. Read More

    Ultraviolet-A1 irradiation therapy for systemic lupus erythematosus.
    Lupus 2017 Jan 1:961203317707064. Epub 2017 Jan 1.
    Veterans Administration, New Orleans, LA, USA.
    Systemic lupus erythematosus (lupus, SLE) is a chronic autoimmune disease characterized by the production of autoantibodies, which bind to antigens and are deposited within tissues to fix complement, resulting in widespread systemic inflammation. The studies presented herein are consistent with hyperpolarized, adenosine triphosphate (ATP)-deficient mitochondria being central to the disease process. These hyperpolarized mitochondria resist the depolarization required for activation-induced apoptosis. Read More

    Drugs for discoid lupus erythematosus.
    Cochrane Database Syst Rev 2017 05 5;5:CD002954. Epub 2017 May 5.
    Department of Dermatology, Broadgreen Hospital, Liverpool, UK, L14 3LB.
    Background: Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus, which can cause scarring. Many drugs have been used to treat this disease and some (such as thalidomide, cyclophosphamide and azathioprine) are potentially toxic. This is an update of a Cochrane Review first published in 2000, and previously updated in 2009. Read More

    Oral manifestations of lupus.
    Ir J Med Sci 2017 May 3. Epub 2017 May 3.
    Department of Dermatology, St. James's Hospital, Dublin, 8, Ireland.
    Introduction: Mucosal involvement is commonly seen in patients with lupus; however, oral examination is often forgotten. Squamous cell carcinoma arising within oral lupoid plaques has been described, emphasizing the importance of identifying and treating oral lupus.

    Methods: We undertook a retrospective single-centre study looking at oral findings in patients attending our multidisciplinary lupus clinic between January 2015 and April 2016. Read More

    Development of new extra-glandular manifestations or associated auto-immune diseases after establishing the diagnosis of primary Sjögren's syndrome : A long-term study of the Antonius Nieuwegein Sjögren (ANS) cohort.
    Rheumatol Int 2017 Jul 19;37(7):1153-1158. Epub 2017 Apr 19.
    Department of Clinical Epidemiology and Medical Statistics, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.
    To investigate in a long-term study, the development of new extra-glandular manifestations (EGM) or associated auto-immune diseases (AID) from 1 year after establishing the diagnosis of primary Sjögren's syndrome (pSS). The primary goal was to examine the frequency and type of these manifestations and to find out which demographic, clinical and serological profile was most at risk. All outpatients diagnosed with primary Sjögren's syndrome were included in a retrospective study, with at least one check-up per year, from June 1991 until August 2015. Read More

    Discoid Lupus and Human Immunodeficiency Virus: A Retrospective Chart Review to Determine the Prevalence and Progression of Co-occurrence of these Conditions at a Single Academic Center.
    Indian J Dermatol 2017 Mar-Apr;62(2):226
    Department of Dermatology, University of California, San Diego, CA, USA.
    Context: Discoid lupus erythematosus (DLE) and human immunodeficiency virus (HIV) are both disorders of the immune system. The pathophysiology of these diseases varies greatly as DLE is characterized by an overactive immune system that attacks normal host cells, whereas HIV is characterized by an exogenous attack on the immune system that depletes it of key cell types. Although the reason is unknown, co-occurrence of DLE and HIV is rare. Read More

    [How I explore… scalp and hairin erythemato-squamous disorders].
    Rev Med Liege 2016 Oct;71(10):460-462
    Service de Dermatopathologie, CHU de Liège, Belgique.
    In their early stages, some dermatoses of the scalp such as psoriasis seborrheic dermatitis, tinea capitis and discoid lupus erythematosus are often hardly noticeable to others. However, the eruptions are occasionally severe and extensive. Reaching an adequate diagnosis is of utmost impor¬tance for an adequate healthcare. Read More

    Predictors of low quality of life in discoid lupus patients.
    Br J Dermatol 2017 Mar 24. Epub 2017 Mar 24.
    University of Texas Southwestern Medical Center, Department of Dermatology, Dallas, TX.
    Discoid lupus erythematosus (DLE) is unique from other cutaneous lupus erythematosus (CLE) subtypes because of dyspigmentation and scarring, which are associated with quality of life (QoL) impairment in other skin disorders.(1, 2) While previous QoL studies have included heterogeneous cohorts of patients with CLE, we focused on patients with DLE to identify clinical and demographic features that correlate with QoL impairment. We hypothesized that greater skin disease activity, skin disease damage, dark skin type, female gender, low socioeconomic status (defined by annual income), and current smoking status would be associated with poorer QoL in patients with DLE. Read More

    Successful treatment of recalcitrant discoid lupus erythematosus with ustekinumab.
    Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.
    Department of Dermatology, Hospital Universitario de Fuenlabrada, Madrid.
    We report a 52-year old woman with a 28-year historyof disfiguring facial discoid lupus erythematosus(DLE), persistent despite both classical therapiesand rituximab. Ustekinumab 45 mg was started incombination with methotrexate and intralesionalcorticosteroids. Methotrexate and intralesionalcorticosteroids were withdrawn 30 months later andustekinumab maintained as monotherapy. Read More

    Immunopathogenic Oral Diseases: An Overview 
Focusing on Pemphigus Vulgaris and Mucous Membrane Pemphigoid.
    Oral Health Prev Dent 2017;15(2):177-182
    Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Read More

    Lupus erythematosus tumidus of the scalp masquerading as alopecia areata.
    Cutis 2017 Feb;99(2):E22-E24
    Dermatology Residency Program, San Antonio Uniformed Services Health Education Consortium, Texas, USA.
    Lupus erythematosus tumidus (LET) is a unique subset of chronic cutaneous lupus erythematosus (CCLE) that generally presents as urticarialike papules and plaques with induration and erythema on the face, trunk, and upper extremities. Lesions rarely present on the scalp or below the waist. We report a unique case of LET on the scalp of a woman that presented clinically as alopecia areata. Read More

    Periorbital discoid lupus: a rare localization in a patient with systemic lupus erythematosus.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):122-124
    Istanbul Medeniyet University School of Medicine - Istanbul, Turkey.
    A 40-year-old female patient with a 5-year history of systemic lupus erythematosus was referred to our policlinic with complaints of erythema, atrophy, and telangiectasia on the upper eyelids for 8 months. No associated mucocutaneous lesion was present. Biopsy taken by our ophthalmology department revealed discoid lupus erythematosus. Read More

    Frontal fibrosing alopecia in association with Sjögren's syndrome: more than a simple coincidence.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):14-16
    Hospital do Servidor Público Estadual do Estado de São Paulo (HSPE) - São Paulo (SP), Brazil.
    Frontal fibrosing alopecia is a distinctive form of scarring alopecia considered to be a clinical variant of lichen planopilaris. It predominantly occurs in postmenopausal women and has a slowly progressive course. It was first described by Kossard in 1994. Read More

    [Rare cutaneous tuberculosis in sub-Saharan Africa developed on discoid lupus erythematous lesion].
    Bull Soc Pathol Exot 2017 Feb 28. Epub 2017 Feb 28.
    Dermatologie, hôpital institut d'hygiène sociale de Dakar, université Cheikh-Anta-Diop de Dakar, BP 7045, Dakar, Sénégal.
    Lupus vulgaris is a common presentation of cutaneous tuberculosis (TB), but its ulcerative or vegetating form also called vorax is rare.We report a case of lupus vulgaris in its vorax form, which occurred in a patient with discoid lupus erythematous. A 42-year-old patient monitored for chronic lupus erythematosus consulted again for a facial tumor and fever. Read More

    Frontal Fibrosing Alopecia Coexisting with Lupus Erythematosus: Poor Response to Hydroxychloroquine.
    Skin Appendage Disord 2017 Jan 12;2(3-4):162-165. Epub 2016 Nov 12.
    Dermatology Clinic, Hospital do Servidor Público Municipal de São Paulo, São Paulo, Brazil.
    Lupus erythematosus, especially the discoid form, and lichen planopilaris may be associated and can occur in different topographies (coexistence) or in the same lesion (lupus eythematosus/lichen planus overlap syndrome). Frontal fibrosing alopecia is considered a variant form of lichen planopilaris and is characterized by frontotemporal hairline and eyebrow involvement. Of the association with lupus erythematosus we have only a few descriptions. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Association study between the TP53 Rs1042522G/C polymorphism and susceptibility to systemic lupus erythematosus in a Chinese Han population.
    Rheumatol Int 2017 Apr 9;37(4):523-529. Epub 2017 Feb 9.
    Department of Information, The Second Hospital of Anhui Medical University, 678 Furong Road Hefei, Anhui, 230601, China.
    Tumour suppressor protein 53 (p53) plays a central role in apoptosis, cell proliferation and death. Previously studies found contribution of functional p53 Arg72Pro polymorphism (TP53 rs1042522G/C polymorphism) in the development of systemic lupus erythematosus (SLE) remains controversial. In this study, for the first time, we evaluated its association with SLE in a Chinese Han population. Read More

    A retrospective study comparing histopathological and immunopathological features of nasal planum dermatitis in 20 dogs with discoid lupus erythematosus or leishmaniosis.
    Vet Dermatol 2017 Apr 29;28(2):200-e46. Epub 2017 Jan 29.
    Veterinaria Cetego, Via M.C. Cetego 20, 00177, Roma, Italy.
    Background: In areas endemic for leishmaniosis, discoid lupus erythematosus (DLE) and canine leishmaniosis (CanL) are the most common differential diagnoses for nasal planum erosive-ulcerative dermatitis in dogs.

    Hypothesis/objective: To compare histopathological and immunopathological features of canine nasal planum erosive-ulcerative dermatitis with depigmentation due to DLE or CanL.

    Animals: Nasal planum biopsies from dogs with nasal planum loss of architecture, depigmentation, swelling, erosions or ulcerations due to DLE (n = 14) or CanL (n = 6). Read More

    High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study.
    J Immunol Res 2017 3;2017:3972706. Epub 2017 Jan 3.
    Department of Dermatology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
    Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control group. Additionally, we intended to determine the differences of sociodemographic and clinical data of the DLE patients with MetS compared to the patients without MetS. Read More

    Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti-Interferon-γ Antibody, in Patients With Discoid Lupus Erythematosus.
    Arthritis Rheumatol 2017 May 31;69(5):1028-1034. Epub 2017 Mar 31.
    Amgen Inc., Thousand Oaks, California.
    Objective: Interferon-γ (IFNγ) is implicated in the pathogenesis of discoid lupus erythematosus (DLE). This study sought to evaluate a single dose of AMG 811, an anti-IFNγ antibody, in patients with DLE.

    Methods: The study was designed as a phase I randomized, double-blind, placebo-controlled crossover study of the pharmacodynamics, safety, and clinical efficacy of AMG 811 in patients with DLE. Read More

    ANA-Negative Presentation of SLE in Man with Severe Autoimmune Neutropenia.
    Case Rep Med 2016 19;2016:6853936. Epub 2016 Dec 19.
    University of California San Diego School of Medicine, La Jolla, CA, USA.
    Background. Systemic lupus erythematosus (SLE) is a chronic, inflammatory, connective tissue disease that commonly affects the joints and a variety of organs due to an overactivation of the body's immune system. There is wide heterogeneity in presentation of SLE patients, including lung, central nervous system, skin, kidney, and hematologic manifestations. Read More

    Oral lichenoid lesions: distinguishing the benign from the deadly.
    Mod Pathol 2017 Jan;30(s1):S54-S67
    Professor Emeritus, Emory University School of Medicine: Atlanta Oral Pathology, Decatur, GA, USA.
    Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus. Read More

    Autoimmune collagen vascular diseases: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):678-689. Epub 2016 Jul 9.
    Assistant Professor of Dermatology, University of Connecticut School of Medicine, Farmington, CT.
    Morphea, dermatomyositis (DM), and discoid lupus erythematosus (DLE) are autoimmune collagen vascular diseases that can present at any age. In all three of these diseases, the tenants of diagnosis and treatment are largely the same in both children and adults, with a few notable differences. Children with morphea are more likely to present with the linear subtype and have a higher incidence of extracutaneous manifestations. Read More

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