3,785 results match your criteria Lupus Erythematosus Discoid


Cutaneous lupus erythematosus and cardiovascular disease: current knowledge and insights into pathogenesis.

Clin Rheumatol 2020 Jul 5. Epub 2020 Jul 5.

Harvard Medical School, Boston, MA, USA.

Multiple autoinflammatory diseases, including psoriasis, psoriatic arthritis, and systemic lupus erythematosus, have been linked to increased risk of cardiovascular disease. Inflammation is known to play a key role in the pathogenesis of atherosclerosis, thus the contribution of systemic immune dysregulation, which characterizes such inflammatory conditions, towards the development of cardiovascular disease has garnered considerable interest. Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease, but risk of cardiovascular disease amongst patients with cutaneous lupus is less well known. Read More

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http://dx.doi.org/10.1007/s10067-020-05257-3DOI Listing

Linear lesions on the arm of a child: a diagnostic challenge.

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Fundacion Universitaria Sanitas. Bogota.

There are a number of conditions that follow the lines of Blaschko. Linear discoid lupus erythematosus is a rare variant of chronic lupus erythematosus with less than 20 cases reported in children. It can be misdiagnosed as lichen striatus or linear morphea. Read More

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Unilateral Blaschko-linear eruption with Gottron-like papules: blaschkoid lupus erythematosus or dermatomyositis?

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

A 6-year-old boy presented with dusky erythematous plaques in linear and whorled pattern over limbs and trunk for the past 1 year along with subcutaneous nodule on the left cheek of 3 months duration. He also had Gottron-like and inverse Gottron-like papules on hands. Histology from truncal lesion showed interface dermatitis with superficial and deep perivascular and periappendageal infiltrate suggestive of discoid cutaneous lupus erythematosus (CLE), while biopsy from facial nodule revealed features of lupus panniculitis. Read More

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http://dx.doi.org/10.1136/bcr-2020-235498DOI Listing

Clinical features, damage accrual, and survival in patients with familial systemic lupus erythematosus: data from a multi-ethnic, multinational Latin American lupus cohort.

Lupus 2020 Jun 30:961203320935184. Epub 2020 Jun 30.

Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina.

Objectives: This study aimed to compare the clinical features, damage accrual, and survival of patients with familial and sporadic systemic lupus erythematosus (SLE).

Methods: A multi-ethnic, multinational Latin American SLE cohort was studied. Familial lupus was defined as patients with a first-degree SLE relative; these relatives were interviewed in person or by telephone. Read More

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http://dx.doi.org/10.1177/0961203320935184DOI Listing

[Modern perspectives of oral squamous cell carcinoma].

Authors:
A A Ivina

Arkh Patol 2020 ;82(3):55-60

Peoples' Friendship University of Russia, Moscow, Russia.

The article is devoted to the modern perspectives of the etiology, pathogenesis, diagnosis and prognostic factors in theoral squamous cell carcinoma. In the new edition of the WHO Classification of Head and Neck Tumors of 2017, the concept of potentially malignant diseases is introduced, which include erythroplakia, leukoplakia, oral submucous fibrosis, dyskeratosiscongenita, smokeless tobacco keratosis, palatallesions associated with reverse smoking, chronic candidiasis, lichen planus, discoid lupus erythematosus, syphilitic glossitis and actinic keratosis (liponly). A binary system for assessing oral epithelial dysplasia assessing is proposed. Read More

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http://dx.doi.org/10.17116/patol20208203155DOI Listing
January 2020

Trigeminal trophic syndrome: an important simulator of discoid cutaneous lupus erythematosus - a case series.

Lupus 2020 Jun 26:961203320935169. Epub 2020 Jun 26.

Department of Dermatology, University of São Paulo, Brazil.

Trigeminal trophic syndrome occurs secondary to trigeminal nerve injury, leading to anaesthesia and paraesthesia, with consequent vigorous facial skin manipulation and lesion production, simulating other facial diseases such as ulcerative discoid lupus erythematosus, tumours and other artificially produced lesions. Ulceration and destruction of the ala nasi is a typical feature besides scratching end excoriations in the cutaneous segment affected. In this series, we present the features of five patients with trigeminal trophic syndrome, highlighting possible confusion with cutaneous lupus. Read More

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http://dx.doi.org/10.1177/0961203320935169DOI Listing

Creation and Validation of Classification Criteria for Discoid Lupus Erythematosus.

JAMA Dermatol 2020 Jun 17. Epub 2020 Jun 17.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: Classification criteria are the standardized definitions that are used to enroll uniform cohorts for research studies. They emphasize high specificity and are distinct from diagnostic criteria. No universally recognized classification criteria currently exist for discoid lupus erythematosus (DLE), which has led to problematic heterogeneity in observational and interventional clinical studies across the field. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.1698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301299PMC

Trichoscopic Findings Of Discoid Lupus Erythematosus Alopecia: A Cross-Sectional Study.

J Am Acad Dermatol 2020 Jun 2. Epub 2020 Jun 2.

Servicio de Dermatología. Hospital Universitario Ramón y Cajal. Departamento de Medicina, Facultad de Medicina, Universidad de Alcalá, IRYCIS. Madrid, Spain; Grupo de Dermatología Pedro Jaén, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.05.144DOI Listing

Mucoscopy of Discoid Lupus Erythematosus on Lower Lip.

Indian Dermatol Online J 2020 Mar-Apr;11(2):296-297. Epub 2020 Mar 9.

Department of Dermatology, NDMC Medical College and Hindu Rao Hospital, New Delhi, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_348_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247652PMC

Discoid Lupus Erythematosus Lesions Associated with Systemic Fluorouracil Agents: A Case Report and Review.

Authors:
Philip R Cohen

Cureus 2020 Apr 25;12(4):e7828. Epub 2020 Apr 25.

Dermatology, San Diego Family Dermatology, National City, USA.

Systemic fluorouracil agents include not only 5-fluorouracil (5FU), but also capecitabine, tegafur, and uracil/tegafur (UFT). Systemic lupus erythematosus (SLE), subacute cutaneous lupus erythematosus (SCLE), and discoid lupus erythematosus (DLE) are subtypes of lupus erythematosus; drug-induced lupus erythematosus can also present in each of these subtypes. This report describes the case of a 65-year-old woman with systemic 5FU-induced DLE. Read More

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http://dx.doi.org/10.7759/cureus.7828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249746PMC

An atypical presentation of alopecia in discoid lupus erythematosus.

J Cutan Pathol 2020 May 22. Epub 2020 May 22.

Department of Dermatology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.

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http://dx.doi.org/10.1111/cup.13758DOI Listing

An Update on the Pathogenesis of Skin Damage in Lupus.

Curr Rheumatol Rep 2020 May 12;22(5):16. Epub 2020 May 12.

Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha, 410011, Hunan, China.

Purpose Of Review: Lupus erythematosus (LE) is characterized by broad and varied clinical forms ranging from a localized skin lesion to a life-threatening form with severe systemic manifestations. The overlapping between cutaneous LE (CLE) and systemic LE (SLE) brings difficulties to physicians for early accurate diagnosis and sometimes may lead to delayed treatment for patients. We comprehensively review recent progress about the similarities and differences of the main three subsets of LE in pathogenesis and immunological mechanisms, with a particular focus on the skin damage. Read More

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http://dx.doi.org/10.1007/s11926-020-00893-9DOI Listing
May 2020
2.454 Impact Factor

The history of lupus throughout the ages.

J Am Acad Dermatol 2020 May 4. Epub 2020 May 4.

Service de Rhumatologie, Hôpitaux universitaires de Strasbourg, Centre National de Référence des maladies auto-immunes et systémiques rares Est/Sud-Ouest (RESO), Strasbourg, France. Electronic address:

The word lupus (Latin term for the wolf) was used indistinctively since the Middle Ages for several types of diseases characterized by ulcerous lesions, mainly in the lower limbs. In the middle of the 18th century, the French dermatologist Cazenave mentioned for the first time the term "lupus érythémateux," while Kaposi reported discoid lupus as a separate entity. The true turning point in the history of lupus occurred at the beginning of the 19th century, when the distinction between lupus vulgaris and cutaneous lupus in its modern sense emerged slowly. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.150DOI Listing

Tumid Lupus Erythematosus and Systemic Lupus Erythematosus: A Report on Their Rare Coexistence.

Cureus 2020 Apr 5;12(4):e7545. Epub 2020 Apr 5.

Rheumatology, Einstein Medical Center, Philadelphia, USA.

Tumid lupus erythematosus (TLE) is a rare variant of cutaneous lupus erythematosus. Clinically, it lacks typical changes found in discoid lupus and antinuclear antibodies (ANA) levels are elevated in only 10% of the patients. Coexistent systemic lupus erythematosus (SLE) has been reported to be rare, and literature shows only a few case reports. Read More

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http://dx.doi.org/10.7759/cureus.7545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199909PMC

Discoid lupus erythematosus of the lip: a case of refractory cheilitis.

Lupus 2020 Jun 6;29(7):804-805. Epub 2020 May 6.

Department of Dermatology, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

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http://dx.doi.org/10.1177/0961203320922302DOI Listing

A novel TRAF3IP2 variant causing familial scarring alopecia with mixed features of discoid lupus erythematosus and folliculitis decalvans.

Clin Genet 2020 Apr 30. Epub 2020 Apr 30.

Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.

Discoid lupus erythematosus (DLE) is an autoimmune disorder with a poorly defined etiology. Despite epidemiologic gender and ethnic biases, a clear genetic basis for DLE remains elusive. In this study, we used exome and RNA sequencing technologies to characterize a consanguineous Lebanese family with four affected individuals who presented with classical scalp DLE and generalized folliculitis. Read More

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http://dx.doi.org/10.1111/cge.13767DOI Listing

Cutaneous polyautoimmunity in two unrelated dogs: pemphigus foliaceus and generalized discoid lupus erythematosus.

Vet Dermatol 2020 Apr 27. Epub 2020 Apr 27.

Department of Clinical Sciences, College of Veterinary Medicine, NC State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.

Background: Polyautoimmunity, the concurrent expression of two or more distinct autoimmune diseases (ADs) in a single individual, is a known phenomenon in humans and has been rarely reported in dogs. To the best of the authors' knowledge, comorbid pemphigus foliaceus (PF) and generalized discoid lupus erythematosus (GDLE) has not been reported in dogs.

Hypothesis/objectives: To describe the clinical, histological and immunological features and treatment outcome of two unrelated dogs with comorbid PF and GDLE. Read More

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http://dx.doi.org/10.1111/vde.12851DOI Listing

Non-bullous neutrophilic lupus erythematosus-Muted bullous disease?

Indian J Pathol Microbiol 2020 Apr-Jun;63(2):305-308

Department of Pathology, ABVIMS and Dr. RML Hospital, New Delhi, India.

Non-bullous neutrophilic lupus erythematosus is a rare form of cutaneous lupus erythematosus (LE). We hereby present a case of 24-year-old female, known case of discoid LE (DLE) with negative ANA stabilized on hydroxychloroquine for 2 years. She reported new occurrence of erythematous, mildly pruritic, papular lesions and painful mucosal ulceration. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_704_19DOI Listing

Different distribution patterns of plasmacytoid dendritic cells in discoid lupus erythematosus and lichen planopilaris demonstrated by CD123 immunostaining.

An Bras Dermatol 2020 May - Jun;95(3):307-313. Epub 2020 Mar 20.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e Tajrish Hospital, Tehran, Iran.

Background: Clinical and histological features may overlap between lichen planopilaris-associated and discoid lupus erythematosus-associated scarring alopecia.

Objectives: The aim of this study was to demonstrate the cutaneous infiltration of plasmacytoid dendritic cells and to compare their distribution pattern in discoid lupus erythematosus and lichen planopilaris.

Methods: Twenty-four cases of discoid lupus erythematosus and 30 cases of lichen planopilaris were examined for immunostaining of the CD123 marker. Read More

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http://dx.doi.org/10.1016/j.abd.2019.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253924PMC

Demodex positive discoid lupus erythematosus: Is it a separate entity or an overlap syndrome?

Dermatol Ther 2020 May 25;33(3):e13394. Epub 2020 Apr 25.

Meram Medicine Faculty, Department of Dermatology, Necmettin Erbakan University, Konya, Turkey.

Discoid lupus erythematosus (DLE) is a chronic inflammatory erythematous skin disease that can be triggered by several factors. Rosacea is another skin disease that causes facial redness and tenderness. Demodex mites have been reported in rosacea and DLE patients commonly in the literature. Read More

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http://dx.doi.org/10.1111/dth.13394DOI Listing

Pigmented linear discoid lupus erythematosus following the lines of Blaschko: A retrospective study of a Chinese series.

Indian J Dermatol Venereol Leprol 2020 Jul-Aug;86(4):359-365

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Skin and Immune Diseases, Beijing, China.

Background: Linear cutaneous lupus erythematosus is a rare subtype of lupus erythematosus (LE) that develops linear lesions following the lines of Blaschko. Linear cutaneous lupus erythematosus may present as various subtypes of LE, including linear discoid lupus erythematosus. There are few reports about pigmentedlinear discoid lupus erythematosus in the literature. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_341_19DOI Listing

Successful treatment of facial localized discoid lupus erythematosus with intralesional betamethasone: A report of three cases.

Dermatol Ther 2020 May 22;33(3):e13389. Epub 2020 May 22.

Institute of Dermatology, Guangzhou Medical University, Guangzhou, China.

Discoid lupus erythematosus (DLE) is a chronic autoimmune skin disease that usually causes disfiguring scarring, dyspigmentation, and atrophy. Despite a range of available topical and systemic therapies, the treatment of DLE remains a therapeutic challenge, especially in some refractory cases. Here, we reported three male patients with long-term chronic lesions of unilateral facial localized DLE, who failed to have their disease controlled with many previous topical/systemic treatments, showed rapid and well response to intralesional injections of betamethasone (2 mg/mL, 0. Read More

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http://dx.doi.org/10.1111/dth.13389DOI Listing

Secukinumab-induced chronic discoid lupus erythematosus.

JAAD Case Rep 2020 Apr 26;6(4):362-364. Epub 2020 Mar 26.

Comprehensive Center for Inflammation Medicine, University Hospital Schleswig-Holstein, Lübeck, Germany.

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http://dx.doi.org/10.1016/j.jdcr.2020.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109566PMC

Inflammatory and T Helper 17/ Regulatory T Cells Related Cytokines Balance in Cutaneous Lupus Erythematosus (CLE).

Iran J Allergy Asthma Immunol 2020 Feb 1;19(1):9-17. Epub 2020 Feb 1.

Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

The cutaneous lupus erythematosus (CLE) is a common manifestation among systemic lupus erythematosus (SLE) patients. Malar rash and discoid lupus (DLE) are in the category of acute and chronic CLE, respectively. The pathogenesis of CLE is multifactorial, and cytokine imbalances contribute to immune dysfunction and the induction of organ damage. Read More

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http://dx.doi.org/10.18502/ijaai.v19i1.2411DOI Listing
February 2020

Discoid drug-induced lupus erythematosus induced by antitumor necrosis factor agents is a very rare subtype of cutaneous lupus: Three cases and literature review.

Dermatol Ther 2020 May 20;33(3):e13364. Epub 2020 Apr 20.

Faculté de Médecine Sorbonne Université, AP-HP, Service de Dermatologie et Allergologie, Hôpital Tenon, Paris, France.

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http://dx.doi.org/10.1111/dth.13364DOI Listing

Cutaneous Lupus Erythematosus: Current and Future Pathogenesis-Directed Therapies.

Yale J Biol Med 2020 03 27;93(1):81-95. Epub 2020 Mar 27.

Department of Dermatology, Yale School of Medicine, New Haven, CT.

Cutaneous lupus erythematosus (CLE) is an autoimmune disease of the skin with significant morbidity. Current treatments are often inadequate to control disease and there are no Food and Drug Administration (FDA)-approved therapies for this potentially debilitating disease, underscoring an unmet medical need. Recent insights into disease pathogenesis have implicated innate and adaptive immune components, including type I and type III interferons in the development of CLE. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087060PMC

A case of discoid lupus erythematosus because of palbociclib.

J Cutan Pathol 2020 Jul 15;47(7):668-670. Epub 2020 Apr 15.

Dermatology Unit, Department of Mentals and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.

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http://dx.doi.org/10.1111/cup.13696DOI Listing

Cutaneous squamous cell carcinoma causing a rhinophymatous mass in a patient with clinically occult hypertrophic lupus erythematosus.

Lupus 2020 May 22;29(6):644-648. Epub 2020 Mar 22.

Department of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, USA.

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http://dx.doi.org/10.1177/0961203320912838DOI Listing

Concordance among in vivo reflectance confocal microscopy, trichoscopy, and histopathology in the evaluation of scalp discoid lupus.

Skin Res Technol 2020 Mar 20. Epub 2020 Mar 20.

Dermatology Department, University of State of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.

Background: Reflectance confocal microscopy (RCM) has been used for the evaluation of several inflammatory skin conditions, including skin discoid lupus erythematosus (DLE), and has been correlated with conventional histopathology (HP). However, RCM is not being widely used in trichology. Few reports and just preliminary data suggest the use of RCM as a complementary tool in alopecias. Read More

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http://dx.doi.org/10.1111/srt.12852DOI Listing

Association of omentin-1, adiponectin, and resistin genetic polymorphisms with systemic lupus erythematosus in a Chinese population.

Int Immunopharmacol 2020 Jun 13;83:106343. Epub 2020 Mar 13.

School of Public Health, Anhui Medical University, Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei 230032, Anhui, China. Electronic address:

Objective: An increasing number of studies have demonstrated the roles of adipokines in systemic lupus erythematosus (SLE). We aimed to investigate the association of genetic variations of omentin-1, adiponectin, and resistin with SLE susceptibility.

Methods: We selected 623 SLE patients and 665 normal controls in the present study. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106343DOI Listing

Delgocitinib: First Approval.

Authors:
Sohita Dhillon

Drugs 2020 Apr;80(6):609-615

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Delgocitinib, a janus kinase (JAK) inhibitor, is being developed by Japan Tobacco for the treatment of autoimmune disorders and hypersensitivity, including inflammatory skin conditions. The JAK family of tyrosine kinases plays an important role in mediating the biological effects of several inflammatory cytokines, e.g. Read More

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http://dx.doi.org/10.1007/s40265-020-01291-2DOI Listing

Complete Remission of Hypertrophic Discoid Cutaneous Lupus Erythematosus After Treatment of Chronic Hepatitis C With Direct-Acting Antivirals.

JAMA Dermatol 2020 Mar 4. Epub 2020 Mar 4.

Department of Dermatology, Hospital Clínic de Barcelona, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1001/jamadermatol.2020.0013DOI Listing

Melanocytic and pseudomelanocytic nests coexist in interface dermatitis from head-neck sun-exposed skin: A report of three cases.

J Cutan Pathol 2020 Jul 20;47(7):649-653. Epub 2020 Mar 20.

Department of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

Discrete junctional cellular aggregates ("nests"), partially staining with melanocytic markers, are described in lichenoid tissue reaction, mainly from chronically sun-exposed skin. The concomitant epidermal flattening and papillary dermal fibrosis with melanophages, may raise the differential diagnosis to that of a regressing melanoma. We describe three cases of interface dermatitis of the head/neck area with clinicopathological features of melanotic discoid lupus erythematosus. Read More

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http://dx.doi.org/10.1111/cup.13672DOI Listing

Patient-Reported Lupus Flare Symptoms Are Associated with Worsened Patient Outcomes and Increased Economic Burden.

J Manag Care Spec Pharm 2020 Mar;26(3):275-283

Vedanta Research, Chapel Hill, North Carolina.

Background: Lupus flares significantly contribute to health resource utilization and hospitalizations. Identification of flare activity may be hindered since validated assessment scales are rarely used in clinical practice and flare severity may fall below clinician-assessed thresholds. Therefore, patient-reported outcomes of lupus flare frequency are important assessment tools for lupus management. Read More

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http://dx.doi.org/10.18553/jmcp.2020.26.3.275DOI Listing

Intralesional overlap syndrome: Sclerodermic lupus panniculitis and sclerodermic discoid lupus erythematosus.

JAAD Case Rep 2020 Mar 12;6(3):166-168. Epub 2020 Feb 12.

Weill Cornell Medicine Department of Pathology and Laboratory Medicine, Division of Dermatopathology, New York, New York.

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http://dx.doi.org/10.1016/j.jdcr.2019.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019040PMC

Periocular discoid lupus erythematosus: diagnostic challenges of a clinical and histopathological masquerader.

Clin Exp Dermatol 2020 Jul 30;45(5):613-615. Epub 2020 Mar 30.

Department of Ophthalmology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/ced.14192DOI Listing

Systemic 5-fluorouracil induced lupus erythematosus: a review of the literature.

Dermatol Online J 2019 Nov 15;25(11). Epub 2019 Nov 15.

Department of Dermatology, University of California San Diego, La Jolla, CA.

Drug-induced subacute cutaneous lupus erythematosus (SCLE) is the most common subtype of drug-induced systemic lupus erythematosus and has been associated with more than 100 drugs. It presents weeks to months after initiation of the culprit medication. The eruption is typically in a photodistribution and it is marked by positive serology to anti-Ro (SSA) antibody. Read More

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November 2019

Do lncRNAs and circRNAs expression profiles influence discoid lupus erythematosus progression?-a comprehensive analysis.

Ann Transl Med 2019 Dec;7(23):728

Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai 200011, China.

Background: Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs)are involved in the progression of discoid lupus erythematosus (DLE), but an understanding of their underlying mechanisms remains elusive. To explore the expression profiles of lncRNAs and circRNAs in DLE, we surveyed the lncRNA/circRNA and mRNA expression profiles in the epithelia of oral DLE and adjacent normal tissues.

Methods: The lesional and non-lesional lower lips of three DLE patients were analysed by RNA-sequencing (RNA-seq). Read More

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http://dx.doi.org/10.21037/atm.2019.12.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990042PMC
December 2019

Immune-mediated Skin Disorders and their Oral Manifestations in the Omani Population: A Hospital-based Study.

Oman Med J 2020 Jan 6;35(1):e84. Epub 2020 Jan 6.

Oral Basic Sciences, Oman Dental College, Muscat, Oman.

Objectives: We sought to determine the prevalence of immune-mediated skin disorders (IMDs), their oral manifestations, and the related comorbidity among Omani patients with IMDs attending the outpatient Department of Dermatology and Dental Clinic at Al Nahdha Hospital, Muscat.

Methods: We conducted a retrospective study of 236 newly-diagnosed patients with IMDs who attended the outpatient clinic between September 2014 and September 2017. Data, such as age, sex, investigations, diagnosis, comorbidity, and associated oral manifestations of the affected individuals, were collected from the hospital health information system. Read More

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http://dx.doi.org/10.5001/omj.2020.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976739PMC
January 2020

Clinicopathological and Immunological Profile of Patients with Cutaneous Manifestations and their Relationship with Organ Involvement in Systemic Lupus Erythematosus Attending a Tertiary Care Center of Eastern India.

Indian J Dermatol 2020 Jan-Feb;65(1):22-28

Department of Dermatology, Calcutta National Medical College, Kolkata, West Bengal, India.

Background: Lupus erythematosus (LE) is an autoimmune disorder with diverse clinical manifestations ranging from mild cutaneous disorder to life-threatening systemic illness and associated with varying immunological parameters.

Aim: We conducted a study in a tertiary care center of eastern India to determine the clinical pattern, immunological profile of patients with cutaneous manifestations of systemic LE (SLE) and their relationship with organ involvement.

Materials And Methods: Fifty-five consecutive patients attending dermatology OPD having features consistent with cutaneous LE and fulfilling the criteria of SLE were included. Read More

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http://dx.doi.org/10.4103/ijd.IJD_282_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986128PMC
February 2020

Intravenous Immunoglobulin in the Management of Lupus Erythematosus Panniculitis.

Cureus 2020 Jan 27;12(1):e6790. Epub 2020 Jan 27.

Department of Dermatology, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU.

Lupus erythematosus panniculitis (LEP) is a rare variant of cutaneous lupus erythematosus (CLE). It is characterized by the presence of a chronic inflammatory process involving the deep dermis and subcutaneous tissues. It commonly presents as deep indurated nodules or sharply demarcated plaques. Read More

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http://dx.doi.org/10.7759/cureus.6790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988482PMC
January 2020

Characteristics and Symptom Severity of Patients Reporting Systemic Lupus Erythematosus in the PatientsLikeMe Online Health Community: A Retrospective Observational Study.

Rheumatol Ther 2020 Mar 1;7(1):201-213. Epub 2020 Feb 1.

BioPharmaceuticals Medical, AstraZeneca, Luton, UK.

Introduction: Online health communities and research networks such as PatientsLikeMe (PLM) capture patient perspectives of diseases, including systemic lupus erythematosus (SLE). We performed a retrospective observational study of data provided by patients in the PLM SLE community to characterize demographics, clinical characteristics, patient experience, and symptom impact.

Methods: Adults who registered with PLM in 2011-2017 and reported SLE diagnosis and treatment with one or more SLE-related drug (antimalarials, immunosuppressives, corticosteroids, calcineurin inhibitors, or biologics) were included in the analysis. Read More

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http://dx.doi.org/10.1007/s40744-020-00195-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021880PMC

A rare form of discoid lupus erythematosus as a rosacea and angiofibroma: A case report.

Clin Case Rep 2020 Jan 19;8(1):155-158. Epub 2019 Dec 19.

Resident of Dermatology Department of Dermatology Skin diseases and leishmaniasis research center Isfahan University of medical science Isfahan Iran.

The rare presentation of DLE can be rosacea-/angiofibroma-like lesions which should be considered in patients with red-pink to skin-color papules with flushing and photosensitivity. Read More

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http://dx.doi.org/10.1002/ccr3.2611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982472PMC
January 2020

Clinic experience in discoid lupus erythematosus: a retrospective study of 132 cases.

Postepy Dermatol Alergol 2019 Dec 21;36(6):739-743. Epub 2018 Aug 21.

Department of Dermatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey.

Introduction: Lupus erythematosus (LE) is an autoimmune disease characterized by a broad range of cutaneous manifestations. Discoid LE (DLE) is the most common chronic manifestation of LE. Literature reviews show that there are a limited number of large-series studies investigating DLE. Read More

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http://dx.doi.org/10.5114/ada.2018.77726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986281PMC
December 2019

Four Cases of Lupus Psychosis: Comment on the Article by Hanly et al.

Arthritis Rheumatol 2020 05 3;72(5):861-863. Epub 2020 Apr 3.

New York-Presbyterian Hospital/Columbia University Irving Medical Center, New York, NY.

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http://dx.doi.org/10.1002/art.41209DOI Listing

A Rare Case of Plasma Cell Gingivitis with Cheilitis.

Case Rep Dent 2019 16;2019:2939126. Epub 2019 Dec 16.

Department of Periodontology, Govt. College of Dentistry, Indore, M.P., India.

Background: Plasma cell gingivitis (PCG) is a rare condition of the gingiva, characterized histopathologically by infiltration of plasma cells in connective tissue. Hypersensitivity reaction due to antigen is considered as primary etiological factor.

Case Presentation: The present case is of an 18-year-old male patient suffering from gingival enlargement along with cheilitis. Read More

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http://dx.doi.org/10.1155/2019/2939126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942776PMC
December 2019

An exophytic and symptomatic lesion of the labial mucosa diagnosed as labial seborrheic keratosis.

Int J Clin Exp Pathol 2019 1;12(7):2749-2752. Epub 2019 Jul 1.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu 610041, Sichuan, P. R. China.

Seborrheic keratosis is a common benign epidermal tumor that occurs mainly in the skin of the face and neck, trunk. The tumors are not, however, seen on the oral mucous membrane. Herein, we describe a case of labial seborrheic keratosis confirmed by histopathology. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949549PMC

Changes of NADH Fluorescence from the Skin of Patients with Systemic Lupus Erythematosus.

Biomed Res Int 2019 24;2019:5897487. Epub 2019 Dec 24.

Department of Dermatology and Venereology, Medical University of Lodz, Poland 90-647 Lodz, Plac J. Hallera 1/6, Łódź, Poland.

Introduction: The blood circulation of the skin is an accessible and representative vascular bed for examining the mechanisms of microcirculatory function. Endothelial function is impaired in systemic lupus erythematosus (SLE), which implies disorders in cell metabolism dependent on blood circulation; however, noninvasive monitoring of metabolism at the tissue and cell level is absent in daily clinical practice.

Objective: The aim of the study was to examine changes of NADH fluorescence from the epidermis of a forearm measured with the flow mediated skin fluorescence (FMSF) technique in patients with SLE and to investigate whether they are associated with clinical manifestation of the disease. Read More

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http://dx.doi.org/10.1155/2019/5897487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942734PMC

Coexistence of ankylosing spondylitis and discoid lupus: A case report.

North Clin Istanb 2019 22;6(4):412-414. Epub 2019 Nov 22.

Department of Physical Medicine and Rehabilitation, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Coexistence of ankylosing spondylitis with connective tissue diseases is very rare. Here, in this study, we describe a coexistence of ankylosing spondylitis and discoid lupus erythematosus in a 35-year-old man. He presented with a 5-year history of low back pain and concurrent development of a discoid rash. Read More

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http://dx.doi.org/10.14744/nci.2018.90922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936951PMC
November 2019