84,849 results match your criteria Lupus Erythematosus Discoid


Better Biomarkers for Lupus Disease Activity - Tools for Treating to Target.

Authors:
Susan A Boackle

Arthritis Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Division of Rheumatology, University of Colorado Denver School of Medicine, Aurora, CO.

Sometimes new ideas come from old places. Complement's central role in lupus pathogenesis has been known for years, and a reduction in C3 and C4 levels is one of the strongest biomarkers for increased lupus disease activity. However, every rheumatologist knows that some patients with no symptoms of active lupus will present with low complement levels, whereas some patients with aggressive disease have levels that never budge from the "normal" range. Read More

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December 2018

HMGB1+ microparticles present in urine are hallmarks of nephritis in patients with systemic lupus erythematosus.

Eur J Immunol 2018 Dec 10. Epub 2018 Dec 10.

Grupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia.

Non-classical monocytes infiltrate the kidney parenchyma and participate in tissue damage in patients with lupus nephritis (LN). Circulating microparticles (MPs) seem to play critical roles in the activation of monocytes in systemic lupus erythematosus (SLE) patients. This study aims to characterize the phenotypes of MPs and monocyte subsets in LN patients and to determine their potential to discriminate between SLE patients with and without LN. Read More

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December 2018

Exosomes in chronic inflammatory skin diseases and skin tumors.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Exosomes are a type of endosome that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Read More

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December 2018
1 Read

In vitro modulatory effect of dehydroepiandrosterone sulfate on apoptosis and expression of apoptosis-related genes in patients with systemic lupus erythematosus.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Rheumatology Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: Systemic lupus erythematosus‌ (SLE) is an autoimmune disease characterized by hyperactive B cells that produce various autoantibodies. Sex hormones have been documented to influence the development of SLE, in which women with SLE have low plasma level of dehydroepiandrosterone sulfate (DHEAS). A strong conclusion about the effect of DHEAS on apoptosis in SLE patients has not been provided. Read More

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December 2018

Mixed connective tissue disease in young Saudi patient with recurrent dental abscess: A case report.

Int J Health Sci (Qassim) 2018 Nov-Dec;12(6):65-68

Department of Paediatric, Paediatric Rheumatology Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Mixed connective tissue disease (MCTD) or overlap syndrome is a rare disease. It has overlapping features of more than one autoimmune disease with high titer of anti-ribonucleoprotein antibodies against U1. We present a 12-year-old Saudi male patient who was presented to the dental clinic complaining from non-healing oral ulcers and multiple periapical abscesses that not responsive to extractions and the use of oral antibiotics, these symptoms were accompanied with persistent fever, headache, muscle weakness, general malaise, and painful bilateral cervical lymphadenopathy. Read More

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December 2018

Cardiac Manifestations in Systemic Lupus Erythematosus: A Case Report and Review of the Literature.

Am J Med Case Rep 2018 ;6(9):180-183

Department of Medicine, Division of Rheumatology, State University of New York, Downstate Medical Center/Health + Hospitals Kings County Brooklyn, NY 11203 USA.

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical features and variable clinical course. SLE tends to affect women during childbearing years and is characterized by multi-organ involvement. Cardiac complications in SLE, which have been described to occur in about 50% of the cases, contributes to significant morbidity and mortality in this population. Read More

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January 2018

Long-lasting cutaneous tuberculosis owing to masquerading as sarcoidosis.

JAAD Case Rep 2019 Jan 27;5(1):1-4. Epub 2018 Nov 27.

Dermatology Department, University Hospital of Bordeaux, Bordeaux, France.

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January 2019

Pericardial Effusion due to Infliximab Therapy for Ulcerative Colitis.

Case Rep Gastrointest Med 2018 6;2018:4324592. Epub 2018 Nov 6.

Department of Internal Medicine, Medstar Washington Hospital Center, USA.

Ulcerative colitis is characterized by ulcers and inflammation of the inner lining of the gastrointestinal tract. Antitumor necrosis factor alpha (anti-TNF alpha) agents such as infliximab are drugs that have been used for the treatment of ulcerative colitis for decades. Infliximab is known to be associated with various adverse effects including anti-TNF alpha induced lupus (ATIL). Read More

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November 2018

Infectious and Noninfectious Acute Pericarditis in Children: An 11-Year Experience.

Int J Pediatr 2018 8;2018:5450697. Epub 2018 Nov 8.

Division of Infectious Diseases, Children's Hospital of Michigan, Detroit, MI, USA.

Objective: The study was undertaken to determine the etiology, review management, and outcome in children diagnosed with acute pericarditis during 11 years at tertiary pediatric institution.

Methods: Retrospective chart review of children diagnosed between 2004 and 2014. Patients with postsurgical pericardial effusions were excluded. Read More

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November 2018

A CD4 T cell population provides B cell help in systemic lupus erythematosus.

Authors:
Susan J Allison

Nat Rev Nephrol 2018 Dec 10. Epub 2018 Dec 10.

Nature Reviews Nephrology, .

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December 2018

Nested Polymerase Chain Reaction and Cutaneous Tuberculosis.

Am J Dermatopathol 2018 Nov 27. Epub 2018 Nov 27.

Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional SXXI, IMSS, Mexico City, México.

The role of Mycobacterium tuberculosis in the etiology and pathogenesis of cutaneous tuberculosis is controversial because of the difficulties associated with demonstrating the presence of these mycobacteria in tuberculid cutaneous lesions by routinely available microbiological and histological techniques. In this study, we aimed to demonstrate the presence of M. tuberculosis in cutaneous tuberculosis. Read More

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November 2018

Association of polymorphisms with neuromyelitis optica spectrum disorders in Han Chinese patients.

Neural Regen Res 2019 Feb;14(2):346-353

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Variants at the GTF2I repeat domain containing 1 (GTF2IRD1)-GTF2I locus are associated with primary Sjögren's syndrome, systemic lupus erythematosus, and rheumatoid arthritis. Numerous studies have indicated that this susceptibility locus is shared by multiple autoimmune diseases. However, until now there were no studies of the correlation between GTF2IRD1-GTF2I polymorphisms and neuromyelitis optica spectrum disorders (NMOSD). Read More

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February 2019

Galectin-9 reflects the interferon signature and correlates with disease activity in systemic autoimmune diseases.

Ann Rheum Dis 2018 Dec 8. Epub 2018 Dec 8.

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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December 2018

16 α-Hydroxyestrone induced adduct generate high affinity autoantibodies in SLE.

Authors:
Wahid Ali Khan

Adv Med Sci 2018 Dec 5;64(1):72-78. Epub 2018 Dec 5.

Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Saudi Arabia. Electronic address:

Purpose: Increased 16 α-hydroxyestrone (16 α-OHE) and autoantibodies against histone H1 (H) have been well described in systemic lupus erythematosus (SLE), but the combination effects of 16 α-OHE and H remains unclear. Here, we tried to assess the affinity and binding specificity of SLE autoantibodies against the 16 α-OHE-H adduct. IgG was induced against this adduct and was also used as immunochemical probe for the estimation of 16 α-OHE in the serum of SLE patients. Read More

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December 2018

Functional Variants of TNFAIP3 are Associated with Systemic Lupus Erythematosus in a Cohort of Chinese Han Population.

Hum Immunol 2018 Dec 4. Epub 2018 Dec 4.

The Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun, China. Electronic address:

Tumor necrosis factor-alpha-induced protein 3 (TNFAIP3) is a negative regulator of NF-κB activity. We previously reported that the paired tandem polymorphic dinucleotides TT>A (rs148314165, rs200820567 of TNFAIP3) conferred the risk for systemic lupus erythematosus (SLE) in European and Korean populations. We investigated the genetic association of the TT>A variants, as well as the functional coding variant rs2230926 in exon 3 of TNFAIP3 in 1229 Chinese Han SLE patients and 1608 matched population controls. Read More

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December 2018

The influence of interferon on healthy and diseased skin.

Cytokine 2018 Dec 6. Epub 2018 Dec 6.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Type I interferons (IFNs) are an immunomodulatory class of cytokines that serve to protect against viral and bacterial infection. In addition, mounting evidence suggests IFNs, particularly type I but also IFNγ, are important to the pathogenesis of autoimmune and inflammatory skin diseases, such as cutaneous lupus erythematosus (CLE). Understanding the role of IFNs is relevant to anti-viral responses in the skin, skin biology, and therapeutics for these IFN-related conditions. Read More

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December 2018

Update on the epidemiology, risk factors, and disease outcomes of systemic lupus erythematosus.

Best Pract Res Clin Rheumatol 2018 04 27;32(2):188-205. Epub 2018 Sep 27.

Rheumatology, Clinical Immunology and Allergy, University of Crete, Medical School, Iraklio, Greece. Electronic address:

Obtaining an updated view of the epidemiology, risk factors, and prognosis of systemic lupus erythematosus (SLE) is pivotal to our understanding of the disease burden. Recent community-based studies with comprehensive methodology provided more accurate disease occurrence estimates and suggested that SLE may be more frequent than previously thought. Gender, race, and socioeconomic status are important disease determinants, and there is increasing appreciation of the contribution of family history and environmental exposures in SLE susceptibility. Read More

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April 2018
2.603 Impact Factor

Difficult-to-diagnose diabetes in a patient treated with cyclophosphamide - the contradictory roles of immunosuppressant agents: a case report.

J Med Case Rep 2018 Dec 10;12(1):364. Epub 2018 Dec 10.

Unidad de Investigación Médica en Endocrinología Experimental, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauhtémoc 330, Colonia Doctores, 06720, Mexico City, Mexico.

Background: Cyclophosphamide may induce autoimmune diabetes through a decrease in suppressor T cells and increase of proinflammatory T helper type 1 response in animal models. In humans, this association is not as clear due to the presence of other risk factors for hyperglycemia, but it could be a precipitant for acute complications.

Case Presentation: A 31-year-old Mestizo-Mexican woman with a history of systemic lupus erythematosus presented with severe diabetic ketoacidosis, shortly after initiating a multi-drug immunosuppressive therapy. Read More

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December 2018

Chylous ascites and podocytopathy as the presentation of childhood lupus-an unusual occurrence.

Lupus 2018 Dec 8:961203318817831. Epub 2018 Dec 8.

1 Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Systemic lupus erythematosus (SLE) is an autoimmune disorder that can affect virtually any organ. Chylous ascites as a presenting manifestation of SLE has been described in a handful of cases in adults. However, to the best of our knowledge this presentation has never been reported in the pediatric age group. Read More

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December 2018

Invasive fungal disease in patients with systemic lupus erythematosus from Southern China: a retrospective study.

Lupus 2018 Dec 8:961203318817118. Epub 2018 Dec 8.

1 Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objective: To investigate the characteristics and associated factors of invasive fungal disease in patients with systemic lupus erythematosus from Southern China.

Methods: A retrospective study was performed. Demographic and clinical characteristics, laboratory data, and radiographic manifestations were recorded. Read More

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December 2018

Disease course patterns in systemic lupus erythematosus.

Lupus 2018 Dec 8:961203318817132. Epub 2018 Dec 8.

Centre for Prognosis Studies in Rheumatic Diseases, Toronto Lupus Clinic, Toronto, Canada.

Background: Disease activity in systemic lupus erythematosus follows three different courses: long quiescent, relapsing remitting and persistently active. However, the patterns of disease course since diagnosis are not known. This study aimed to assess the prevalence and characteristics of such patterns over 10 years. Read More

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December 2018

Are serum autoantibodies associated with brain changes in systemic lupus erythematosus? MRI data from the Leiden NP-SLE cohort.

Lupus 2018 Dec 8:961203318816819. Epub 2018 Dec 8.

1 Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.

Objective: The effect of serum autoantibodies on the brain of systemic lupus erythematosus (SLE) patients remains unclear. We investigated whether serum autoantibodies, individually and assessed in groups, are associated with specific brain-MRI abnormalities or whether these structural changes are associated with other SLE-related or traditional cardiovascular disease risk factors.

Methods: All patients underwent brain 3Tesla-MRI. Read More

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December 2018

HPV vaccines and lupus: current approaches towards preventing adverse immune cross-reactivity.

Expert Rev Vaccines 2018 Dec 10. Epub 2018 Dec 10.

c Department of Medicine B and Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat-Gan; Sackler Faculty of Medicine , Tel-Aviv University , Tel-Aviv , Israel.

Introduction: If not properly treated, human papillomavirus (HPV) infection may evolve from a common sexually transmitted disease to genital warts and cervical cancer. Various prophylactic HPV vaccines (HPVv), approved to reduce the incidence of the infection, have been found to be effective and safe; however, accounts of post-vaccination autoimmune phenomena, including systemic lupus erythematosus (SLE), have been reported in genetically susceptible individuals. Areas covered: Infectious agents play a role in breaking the immunologic tolerance to self-antigens, resulting in autoimmune events. Read More

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December 2018

Discovery and qualification of candidate urinary biomarkers of disease activity in lupus nephritis.

J Proteome Res 2018 Dec 10. Epub 2018 Dec 10.

Lupus nephritis (LN) is a severe clinical manifestation of systemic lupus erythematosus (SLE) associated with significant morbidity and mortality. Assessment of severity and activity of renal involvement in SLE requires a kidney biopsy, an invasive procedure with limited prognostic value. Non-invasive biomarkers are needed to inform treatment decisions and to monitor disease activity. Read More

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December 2018

The incidence of herpes zoster in cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

Authors:
Eden Lake

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La, Grange Park, IL. Electronic address:

The incidence of zoster is increased in many autoimmune diseases. This study found a significantly increased zoster incidence in dermatomyositis and cutaneous lupus erythematosus compared with a control group.Physicians should be aware of this risk and consider administering the vaccine against zoster to these patients if not contraindicated. Read More

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December 2018
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Discovery of affinity-based probes for Btk occupancy assay.

ChemMedChem 2018 Dec 6. Epub 2018 Dec 6.

SWITZERLAND.

Bruton's tyrosine kinase (Btk) is an attractive target for the treatment of a wide array of B-cell malignancies and autoimmune diseases. Small molecule covalent irreversible Btk inhibitors targeting Cys481 have been developed for the treatment of the aforementioned diseases. In clinical trials, probe molecules are required in occupancy studies to measure the level of engagement of the Btk protein by these Btk covalent irreversible inhibitors. Read More

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December 2018
1 Read

Anetoderma and Systemic Lupus Erythematosus: Case Report and Literature Review.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Pontevedra University Hospital, EOXI Pontevedra-Salnés, Centro de Especialidades Mollavao, c/ Simón Bolívar s/n., ES-36001 Pontevedra, Spain.

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December 2018
1 Read

Coexistence of systemic lupus erythematosus with Kikuchi-Fujimoto disease involving the salivary gland, initially disguised as lymphoma.

Rheumatology (Oxford) 2018 Dec 5. Epub 2018 Dec 5.

Division of Rheumatology, Department of Internal Medicine, Jeonju, Republic of Korea.

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December 2018

Antiphospholipid score is a novel risk factor for idiopathic osteonecrosis of the femoral head in patients with systemic lupus erythematosus.

Rheumatology (Oxford) 2018 Dec 6. Epub 2018 Dec 6.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Objectives: Idiopathic osteonecrosis of the femoral head (ION) is a common complication of SLE associated with CS therapy. Although the pathogenesis of ION involves local bone ischaemia favoured by thrombophilia, the involvement of aPL in lupus ION remains to be elucidated. We have previously reported the aPL score (aPL-S) as a quantitative marker of aPL and the development of thrombotic events in autoimmune diseases. Read More

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December 2018

Unilateral Eyelid Plaque Leading to Diagnosis of Systemic Lupus Erythematosus.

J Clin Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

From the Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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December 2018

A Report of Chronic Intestinal Pseudo-obstruction Related to Systemic Lupus Erythematosus.

Open Med (Wars) 2018 25;13:562-564. Epub 2018 Nov 25.

Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.

Chronic intestinal pseudo-obstruction (CIPO) is a functional gastrointestinal disorder with symptoms of ileus. CIPO can either be idiopathic or secondary to other diseases such as systemic lupus erythematosus (SLE). SLE is involved in many parts of the gastrointestinal system with variable clinical presentations. Read More

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November 2018
1 Read

Combining Bayesian genetic clustering and ecological niche modeling: Insights into wolf intraspecific genetic structure.

Ecol Evol 2018 Nov 30;8(22):11224-11234. Epub 2018 Oct 30.

WSL Swiss Federal Research Institute Birmensdorf Switzerland.

The distribution of intraspecific genetic variation and how it relates to environmental factors is of increasing interest to researchers in macroecology and biogeography. Recent studies investigated the relationships between the environment and patterns of intraspecific genetic variation across species ranges but only few rigorously tested the relation between genetic groups and their ecological niches. We quantified the relationship of genetic differentiation () and the overlap of ecological niches (as measured by -dimensional hypervolumes) among genetic groups resulting from spatial Bayesian genetic clustering in the wolf () in the Italian peninsula. Read More

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November 2018

Population responses of common ravens to reintroduced gray wolves.

Ecol Evol 2018 Nov 30;8(22):11158-11168. Epub 2018 Oct 30.

Yellowstone Center for Resources Yellowstone National Park Wyoming.

Top predators have cascading effects throughout the food web, but their impacts on scavenger abundance are largely unknown. Gray wolves () provide carrion to a suite of scavenger species, including the common raven (). Ravens are wide-ranging and intelligent omnivores that commonly take advantage of anthropogenic food resources. Read More

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November 2018

Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Systemic Autoimmunity Branch, Intramural Research Program (IRP), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and.

The peptidylarginine deiminases PAD2 and PAD4 are implicated in the pathogenesis of several autoimmune diseases. PAD4 may be pathogenic in systemic lupus erythematosus (SLE) through its role in neutrophil extracellular trap (NET) formation that promotes autoantigen externalization, immune dysregulation, and organ damage. The role of this enzyme in mouse models of autoimmunity remains unclear, as pan-PAD chemical inhibitors improve clinical phenotype, whereas PAD4-KO models have given conflicting results. Read More

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December 2018

Hemagglutinin stalk-reactive antibodies interfere with influenza virus neuraminidase activity by steric hindrance.

J Virol 2018 Dec 5. Epub 2018 Dec 5.

Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA.

Hemagglutinin (HA) stalk-reactive antibodies are the basis of several current "one-shot" universal influenza vaccine efforts because they protect against a wide spectrum of influenza virus strains. The appreciated mechanism of protection by HA-stalk antibodies is to inhibit HA stalk reconfiguration, blocking viral fusion and entry. This study shows that HA stalk-reactive antibodies also inhibit neuraminidase (NA) enzymatic activity, prohibiting viral egress. Read More

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December 2018

Siglec-1 Macrophages and the Contribution of IFN to the Development of Autoimmune Congenital Heart Block.

J Immunol 2018 Dec 5. Epub 2018 Dec 5.

Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016.

Given that diseases associated with anti-SSA/Ro autoantibodies, such as systemic lupus erythematosus and Sjögren syndrome, are linked with an upregulation of IFN and type I IFN-stimulated genes, including sialic acid-binding Ig-like lectin 1 (Siglec-1), a receptor on monocytes/macrophages, recent attention has focused on a potential role for IFN and IFN-stimulated genes in the pathogenesis of congenital heart block (CHB). Accordingly, three approaches were leveraged to address the association of IFN, IFN-stimulated genes, and the phenotype of macrophages in affected fetal cardiac tissue: 1) cultured healthy human macrophages transfected with hY3, an anti-SSA/Ro-associated ssRNA, 2) RNA isolated from freshly sorted human leukocytes/macrophages after Langendorff perfusion of three fetal hearts dying with CHB and three healthy gestational age-matched hearts, and 3) autopsy tissue from three additional human CHB hearts and one healthy heart. TLR ligation of macrophages with hY3 led to the upregulation of a panel of IFN transcripts, including SIGLEC1, a result corroborated using quantitative PCR. Read More

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December 2018

The Perceived Stress Scale-10 (PSS-10) is reliable and has construct validity in Chinese patients with systemic lupus erythematosus.

Lupus 2018 Dec 5:961203318815595. Epub 2018 Dec 5.

1 School of Nursing, Tianjin Medical University, Tianjin City, People's Republic of China.

Systemic lupus erythematosus is a chronic, progressive, autoimmune disease that causes significant stress on patients. There is no specific instrument for assessing stress in Chinese systemic lupus erythematosus patients. The objective of this study was to test the reliability and validity of the 10-item Perceived Stress Scale in Chinese systemic lupus erythematosus patients. Read More

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December 2018
1 Read

The contribution of PTPN22 to rheumatological disease.

Arthritis Rheumatol 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, University of California San Diego, 9500 Gilman Drive, MC0656, La Jolla, CA, 92093-0656.

One of the unresolved questions in modern medicine is why certain individuals develop a disorder such as rheumatoid arthritis or lupus, while others do not. Contemporary science holds genetics partly responsible and blames the remainder on environmental and stochastic factors. Among the many genes that increase the risk of autoimmune conditions, the risk allele encoding the W620 variant of PTPN22 is shared between multiple rheumatologic diseases, suggesting a fundamental role in the development of immune dysfunction. Read More

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December 2018

Monitoring disease activity in systemic lupus erythematosus with single-molecule array digital ELISA quantification of serum interferon-α.

Arthritis Rheumatol 2018 Dec 3. Epub 2018 Dec 3.

Sorbonne Université, Inserm UMRS1135, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Assistance Publique-Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, Département d'ImmunologieParis, France.

Objectives: No simple or standardized assay is available to quantify interferon-α (IFNα) in routine clinical practice. Single-molecule-array (Simoa) digital enzyme-linked immunosorbent assay (ELISA) technology enables direct IFNα quantification at fg/mL concentrations. This study was undertaken to assess IFNα digital ELISA diagnostic performances to monitor systemic lupus erythematosus (SLE) activity. Read More

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December 2018

Correction to: Anti-Müllerian hormone serum levels in systemic lupus erythematosus patients: influence of the disease severity and therapy on the ovarian reserve.

Endocrine 2018 Dec 1. Epub 2018 Dec 1.

Institute of Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy.

The original version of this article unfortunately contained a mistake in given and family names of all the authors. Read More

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December 2018

Ischemic stroke as initial manifestation of systemic lupus erythematosus: A case report and review of the literature.

eNeurologicalSci 2018 Dec 9;13:26-30. Epub 2018 Nov 9.

Department of Neurology, University Hospital of Heraklion, University of Crete, Greece.

Stroke is a frequent occurrence among patients suffering from systemic lupus erythematosus (SLE), but it rarely occurs as the initial manifestation of the disease. We here present the case of a 37 year-old patient who developed an acute cerebellar ischemic stroke as initial event of SLE: elevated partial thromboplastin time and ESR, thrombocytopenia, anti-ds-DNA, anti-SSA, anti-JO-1, and the lupus anticoagulant were detected, and the diagnosis of SLE was established. In addition, we reviewed the literature in order to clarify the demographic, clinical, imaging and outcome characteristics of such a presentation, and found 10 similar cases. Read More

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December 2018
1 Read

Lamotrigine-induced Systemic Lupus Erythematosus: A Diagnostic Dilemma.

Indian Dermatol Online J 2018 Nov-Dec;9(6):445-447

Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Many drugs are known to cause systemic lupus erythematosus (SLE), however there are no well defined criteria for drug induced lupus erythematosus (DILE). We present a rare case of lamotrigine induced lupus presenting as acute syndrome of apoptotic pan epidermolysis (ASAP). Read More

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December 2018

Cytomegaloviral or Pneumonia Increases Mortality in Systemic Lupus Erythematosus Patients with Pulmonary Hemorrhage: Evidence from Bronchoalveolar Lavage Fluid.

J Rheumatol 2018 Dec 1. Epub 2018 Dec 1.

From the Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei City; Faculty of Medicine, National Yang-Ming University, Taiwan and Institute of Clinical Medicine, National Yang-Ming University, Taipei City, Taiwan. The study was funded partially by grants from Taipei Veterans General Hospital (V107A-005 and V107B-018). The funder has no role in study design, data collection, analysis, and interpretation of data, writing the manuscript, and the decision to submit this work for publication. Y.S. Sun, MD, Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, and Faculty of Medicine, National Yang-Ming University; D.F. Huang, MD, Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, and Faculty of Medicine, National Yang-Ming University; F.C. Lin, MD, PhD, Department of Chest Medicine, Taipei Veterans General Hospital, and Faculty of Medicine, National Yang-Ming University; C.K. Hsu, MD, Department of Chest Medicine, Taipei Veterans General Hospital Yuli Branch; I.T. Sun, MD, Department of Ophthalmology, E-Da Hospital, I-Shou University; S.C. Chang, MD, PhD, Professor, Department of Chest Medicine, Taipei Veterans General Hospital, and Institute of Emergency and Critical Care Medicine, National Yang-Ming University; C.Y. Tsai, MD, PhD, Professor, Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, and Faculty of Medicine, National Yang-Ming University; C.C. Lai, MD, Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, and Faculty of Medicine, and Institute of Clinical Medicine, National Yang-Ming University. Address correspondence to Dr. C.C. Lai, Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei City, Taiwan 11217 (R.O.C.). E-mail: Accepted for publication August 10, 2018.

Objective: To evaluate the role of cytomegaloviral or pneumonia (CMV/PJP) in systemic lupus erythematosus (SLE) patients with pulmonary hemorrhage (PH).

Methods: We retrospectively examined hospital records for 27 SLE patients with PH who received bronchoalveolar lavage fluid (BALF) analyses. Clinical profile and mortality rates were compared between groups with and without CMV/PJP. Read More

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December 2018

Response to: "Antinuclear autoantibodies: discordance among four different assays" by Pacheco .

Ann Rheum Dis 2018 Dec 1. Epub 2018 Dec 1.

Division of Nephrology, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.

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December 2018

TTP: long-term outcomes following recovery.

Authors:
James N George

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):548-552

Hematology-Oncology Section, Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Although risk for relapse may be the greatest concern following recovery from acquired, autoimmune thrombotic thrombocytopenic purpura (TTP), there are multiple other major health issues that must be recognized and appropriately addressed. Depression may be the most common disorder following recovery from TTP and may be the most important issue for the patient's quality of life. Severe or moderate depression has occurred in 44% of Oklahoma Registry patients. Read More

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November 2018

The rheumatology/hematology interface: CAPS and MAS diagnosis and management.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):313-317

Department of Medicine, Division of Hematology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Catastrophic antiphospholipid antibody syndrome (CAPS) and macrophage activation syndrome (MAS) are both life-threatening hematologic disorders that infrequently afflict patients with rheumatologic disease. CAPS is characterized by fulminant multiorgan damage related to small vessel thrombosis in the setting of persistent antiphospholipid antibodies. It can occur in patients with rheumatologic diseases such as systemic lupus erythematosus but can also affect patients who do not have rheumatologic disease. Read More

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November 2018

Reprint of "The interaction between environmental triggers and epigenetics in autoimmunity".

Authors:
Bruce Richardson

Clin Immunol 2018 Nov 30. Epub 2018 Nov 30.

Department of Internal Medicine, Division of Rheumatology, University of Michigan, SRB 3007, 109 Zina Pitcher Pl., Ann Arbor, MI 48109-2200, United States. Electronic address:

Systemic lupus erythematosus flares when genetically predisposed people encounter environmental agents that cause oxidative stress, such as infections and sunlight. How these modify the immune system to initiate flares is unclear. Drug induced lupus models demonstrate that CD4+ T cells epigenetically altered with DNA methylation inhibitors cause lupus in animal models, and similar T cells are found in patients with active lupus. Read More

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November 2018

Kidney transplantation in systemic lupus erythematosus: Outcomes and prognosis.

Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.

Servicio de Nefrología, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, Madrid, España; Red de Investigación Renal (REDinREN), Madrid, España.

Introduction: The outcome and prognosis of systemic lupus erythematosus (SLE) in long-term kidney transplantation (KT) is variable. The objective of this study was to analyse the survival of the graft and the patient, comparing rates with a control group (primary glomerulonephritis [PGN]).

Materials And Methods: Forty-three patients receiving a KT with diagnosis of lupus nephritis (LN) and 367 patients with PGN were compared between January 1980 and December 2014. Read More

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November 2018
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