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    Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity.
    Sci Rep 2018 Feb 22;8(1):3462. Epub 2018 Feb 22.
    Department of Rheumatology, 1st Affiliated Hospital of China Medical University, Shen Yang, China.
    We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM, anti-double-stranded DNA antibody (Anti-dsDNA Ab) and hemoglobin (Hb) levels and white blood cell (WBC) and platelet (PLT) counts, were performed using standard methods. Lupus nephritis (LN) was diagnosed according to the American College of Rheumatology (ACR) renal criteria. Read More

    Lupus and scleroderma overlap features in a 28-year-old man with anti-PL-12 anti-synthetase syndrome.
    Dermatol Online J 2017 Sep 15;23(9). Epub 2017 Sep 15.
    Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
    A 28-year-old man with clinically and laboratory diagnosed anti-PL-12 anti-synthetase syndrome (AS) in 2009 developed cutaneous lupus lesions, discoid lupus lesions, and sclerodacytly with finger-tip ulcerations four years following his AS diagnosis. Laboratory tests including +ANA, +anti-dsDNA antibody, +anti-Smith antibody, and +anti-RNP antibody in 2014 confirmed the diagnosis of progression to an overlap syndrome including systemic lupus erythematosus. The patient now also has clinical findings (sclerodacytly, Raynaud phenomenon, finger-tip ulcerations) consistent with scleroderma overlap. Read More

    The lupus patient with positive rheumatoid factor.
    Lupus 2018 Jan 1:961203318759607. Epub 2018 Jan 1.
    1 Rheumatology Service, Evangelical University Hospital of Curitiba, Curitiba, Brazil.
    Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study of 467 SLE patients seen at a single rheumatology unit was conducted. Read More

    The use of SLICC and ACR criteria to correctly label patients with cutaneous lupus and systemic lupus erythematosus.
    Clin Rheumatol 2018 Mar 1;37(3):817-818. Epub 2018 Feb 1.
    Dermatology Department, St. James's Hospital, Dublin, Ireland.
    The American College of Rheumatology (ACR) classification criteria for lupus and Systemic Lupus International Collaborating Clinics (SLICC) criteria are designed to classify disease. However, they have become widely used as diagnostic criteria in clinical situations. Patients may be labelled as systemic lupus erythematosus (SLE) in their medical records, when in fact they have cutaneous lupus erythematosus (CLE) without systemic symptoms. Read More

    Primary cutaneous anaplastic large-cell lymphoma: A case report.
    Medicine (Baltimore) 2018 Jan;97(4):e9645
    Rationale: Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare cancer belonging to the group of primary T-cell lymphoproliferative diseases. C-ALCL is characterized by the presence of single or multiple ulcerated lesions on the skin's surface.

    Patient Concerns: This is the case of a 73-year-old man who reported to the Clinic of Cranio-Maxillofacial and Oral Surgery and Implantology, Medical University of Warsaw, owing to a skin tumor in the right parotideomasseteric region, initially diagnosed as discoid lupus erythematosus. Read More

    Primary scarring alopecia: A retrospective study of 89 patients in Taiwan.
    J Dermatol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
    Primary scarring alopecia (PSA) is caused by irreversible damage to the hair epithelial stem cells that reside in hair follicles. There is limited published work regarding PSA amongst the Asian population. The aim of this study was to evaluate the clinical features and to characterize the subtypes of PSA in southern Taiwan. Read More

    Computerized planimetry to assess clinical responsiveness in a phase II randomized trial of topical R333 for discoid lupus erythematosus.
    Br J Dermatol 2018 Jan 16. Epub 2018 Jan 16.
    Corporal Michael J. Crescenz Veterans Affairs Medical Center (Philadelphia), Philadelphia, PA.
    Background: R333 is a topical janus kinase and spleen tyrosine kinase inhibitor being evaluated for discoid lupus erythematosus (DLE) treatment. There is no validated measure to assess area of active DLE lesions.

    Objectives: To evaluate R333 efficacy and assess a technique to measure responsiveness. Read More

    Individuals living with lupus: findings from the LUPUS UK Members Survey 2014.
    Lupus 2018 Apr 8;27(4):681-687. Epub 2018 Jan 8.
    1 Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
    Systemic lupus erythematosus (SLE) is a complex and unpredictable disease which varies greatly among patients and has a significant impact on an individual's daily living and quality of life. A better understanding of the patients' experiences with the disease is vital to the effective management of the disease. LUPUS UK, a national UK-registered charity supporting people with systemic and discoid lupus, conducted a UK-wide survey of individuals living with lupus in order to provide foundation information to support and identify gaps needing further research. Read More

    Naked Hair Shafts as a Marker of Cicatricial Alopecia.
    Am J Dermatopathol 2017 Dec 28. Epub 2017 Dec 28.
    Departments of Dermatology, and.
    Naked hair shafts (NHS) are free-floating hair shafts devoid of surrounding epithelium, supporting structures, and/or embedded in inflammation that may result from destruction of hair follicles by scarring processes such as inflammation and fibroplasia. Extensive examination of NHS has not been performed in scalp biopsies of alopecia. We retrospectively evaluated 622 scalp biopsies of alopecia [345 cicatricial alopecias (central centrifugal cicatricial alopecia, lichen planopilaris, discoid lupus erythematosus, acne keloidalis nuchae, and folliculitis decalvans] and 277 non-cicatricial alopecias [alopecia areata, androgenic alopecia, telogen effluvium, and psoriatic alopecia)] for the presence of NHS. Read More

    White rosettes in discoid lupus erythematosus: a new dermoscopic observation.
    Dermatol Pract Concept 2017 Oct 31;7(4):9-11. Epub 2017 Oct 31.
    BLDE University's Shri M B Patil Medical College, Vijayapura, India.
    White rosettes are shiny white structures seen as four oval-shaped points that come together in the center. They resemble four-leaf clover [1]. Earlier it was thought they were specific for actinic keratosis and squamous cell carcinoma, but they are noted in many other conditions [2]. Read More

    Blue-White Veil as Novel Dermatoscopic Feature in Discoid Lupus Erythematosus in 2 African-American Patients.
    Skin Appendage Disord 2017 Oct 10;3(4):211-214. Epub 2017 Jun 10.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
    Dermoscopic features of discoid lupus erythematosus (DLE) depend on the stage of the lesions: active lesions include yellow-brown dots and red dots, whereas longstanding inactive lesions show absence of follicular openings, cicatricial milky red or white patches, structureless white and brown areas, and thick arborizing vessels. Loss of pinpoint white dots, blue-gray dots in a speckled pattern, and a peripheral pigmented network have been described on dermoscopy of DLE in dark skin. We report a blue-white veil as a novel dermoscopic feature in 2 cases of biopsy-proven DLE in African-American patients. Read More

    Yellow dots in trichoscopy: relevance, clinical significance and peculiarities.
    An Bras Dermatol 2017 Sep-Oct;92(5):724-726
    Alopecia Outpatient Clinic at Hospital Naval Marcílio Dias (HNMD) - Rio de Janeiro (RJ), Brazil.
    Yellow dots are follicular ostium filled with keratin and/or sebum. Initially, they were exclusively associated with alopecia areata. Currently they have also been described in androgenetic alopecia, chronic cutaneous (discoid) lupus erythematosus, and dissecting cellulitis. Read More

    A rare case of unilateral discoid lupus erythematosus mimicking lupus vulgaris.
    BMJ Case Rep 2017 Nov 8;2017. Epub 2017 Nov 8.
    Department of Dermatology, Delhi Dermpath Laboratory, New Delhi, India.
    Discoidlupus erythematosus (DLE) is a chronic type of cutaneous lupus erythematosus which can present in various morphologies, and the diagnosis can be rather confounding. Prompt evaluation and treatment is necessary to prevent disfigurement and systemic involvement associated with DLE. The following case presented a diagnostic dilemma as the lesion mimicked lupus vulgaris. Read More

    Monogenic interferonopathies: Phenotypic and genotypic findings of CANDLE syndrome and its overlap with C1q deficient SLE.
    Int J Rheum Dis 2018 Jan 8;21(1):208-213. Epub 2017 Nov 8.
    Department of Allergy and Immunology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
    Objective: To report the clinical and genetic features of the first cases of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome in an Arab population and to compare them with patients of C1q deficient systemic lupus erythematosus (SLE).

    Materials And Methods: This is a retrospective case series of patients with CANDLE syndrome and C1q deficient SLE seen at a single tertiary hospital. Medical records were reviewed for demographic data, clinical and laboratory features, histopathology and imaging findings, and response to therapeutic intervention. Read More

    Dramatic effect of hydroxychloroquine on lupus alopecia.
    J Dermatol 2018 Feb 25;45(2):194-197. Epub 2017 Oct 25.
    Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
    Lupus alopecia is usually difficult to treat. We report a case of a 40-year-old woman with Sjögren's syndrome and atopic dermatitis who presented with discoid lupus erythematosus on the forearms and lupus erythematosus profundus with alopecia involving the scalp. A biopsy specimen taken from the discoid lupus erythematosus lesion on the forearm further exhibited a xanthomatous reaction, which however was not detected in another specimen from the lupus erythematosus profundus on the scalp. Read More

    Initial digital vasculitis in a large multicenter cohort of childhood-onset systemic lupus erythematosus.
    Rev Bras Reumatol Engl Ed 2017 Nov - Dec;57(6):583-589. Epub 2017 Oct 16.
    Universidade Federal de São Paulo (UNIFESP), Unidade de Reumatologia Pediátrica, São Paulo, SP, Brazil. Electronic address:
    Objectives: To assess clinical digital vasculitis (DV) as an initial manifestation of childhood-onset systemic lupus erythematosus (cSLE) within a large population.

    Methods: Multicenter cross-sectional study including 852 cSLE patients (ACR criteria) followed in ten Pediatric Rheumatology centers in São Paulo State, Brazil.

    Results: DV was observed in 25/852 (3%) cSLE patients. Read More

    Multiple primary squamous cell carcinomas of the lower lip and tongue arising in discoid lupus erythematosus: a case report.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Feb 30;125(2):e22-e30. Epub 2017 Aug 30.
    Department of Oral Pathology and Medicine, School of Dentistry, National and Kapodistrian University of Athens, Greece.
    Squamous cell carcinoma (SCC) developing in lesions of discoid lupus erythematosus (DLE) is rare, most frequently arising on sun-exposed skin and very rarely affecting the lips. A review of the English language literature revealed only 21 published cases of labial SCC in patients with DLE. Here, an unusual case of a patient with DLE who developed 3 primary SCCs of the oral and perioral region is presented. Read More

    Not Just Skin Deep: Systemic Disease Involvement in Patients With Cutaneous Lupus.
    J Investig Dermatol Symp Proc 2017 Oct;18(2):S69-S74
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:
    Cutaneous lupus erythematosus, specifically discoid lupus erythematosus, disproportionately affects those with skin of color and may result in greater dyspigmentation and scarring in darker skin types. In this article, we review investigations relevant to cutaneous lupus patients with skin of color at University of Texas Southwestern Medical Center, associations and risk of progression to systemic lupus, and recommendations for monitoring for systemic disease spread. Between 5% and 25% of patients with cutaneous lupus can develop systemic lupus. Read More

    Primary Idiopathic Pseudopelade of Brocq in a Young Child.
    Int J Trichology 2017 Jul-Sep;9(3):113-115
    Department of Leprosy, Pramukshwami Medical College, Karamsad, Gujarat, India.
    Pseudopelade of Brocq (PPB) is a rare, chronic, slowly progressive cicatricial alopecia that generally affects middle-aged women. Vertex and parietal scalp are commonly involved. It can be primary or secondary to end stage of other scarring alopecia such as lichen planopilaris and discoid lupus erythematosus. Read More

    Discoid Lupus Erythematosus Presenting as Upper Eyelid Edema and Erythema.
    Acta Med Iran 2017 Jul;55(7):474-476
    Department of Dermatology, Skin Research Center, Guilan University of Medical Sciences, Rasht, Iran.
    Discoid Lupus Erythematosus (DLE) is an autoimmune disorder that usually occurs on sun exposed areas of head and neck. Infrequently it could be presented by palpebral involvement and rarely unilateral upper eye lid edema and erythema have been reported as the sole manifestation of DLE. We describe a 38-year-old woman with chronic left upper eye lid edema and erythema from one year ago which was induced by steroid injection for left eyebrow alopecia. Read More

    Steady-state pharmacokinetics of hydroxychloroquine in patients with cutaneous lupus erythematosus.
    Lupus 2017 Jan 1:961203317727601. Epub 2017 Jan 1.
    4 University Hospital of North Durham, Department of Dermatology, North Road Durham, DH1 5TW, Institute of Cellular Medicine, 5994 Newcastle University , UK.
    Background Hydroxychloroquine (HCQ), a 4-aminoquinolone antimalarial, is regarded as the oral therapy of choice for cutaneous and systemic lupus erythematosus (SLE). It is also licensed for rheumatoid arthritis (RA). Studies of HCQ-treated patients with SLE or RA have demonstrated a positive correlation between whole-blood HCQ levels and clinical response. Read More

    Chronic cutaneous lupus erythematosus presenting as atypical acneiform and comedonal plaque: case report and literature review.
    Lupus 2017 Jan 1:961203317726377. Epub 2017 Jan 1.
    Hospital do Servidor Público Municipal de São Paulo (HSPM), São Paulo, Brazil.
    Introduction Chronic cutaneous lupus erythematosus (CCLE) usually presents as characteristic erythematous patches and infiltrated coin-shaped plaques. However, there are some atypical clinical variants that may mimic other dermatological conditions. Haroon et al. Read More

    Autoimmune phenotype with type I interferon signature in two brothers with ADA2 deficiency carrying a novel CECR1 mutation.
    Pediatr Rheumatol Online J 2017 Aug 22;15(1):67. Epub 2017 Aug 22.
    Department of Pediatrics, Medical Faculty, Technical University Dresden, Dresden, Germany.
    Background: Loss-of-function CECR1 mutations cause polyarteritis nodosa (PAN) with childhood onset, an autoinflammatory disorder without significant signs of autoimmunity. Herein we describe the unusual presentation of an autoimmune phenotype with constitutive type I interferon activation in siblings with adenosine deaminase 2 (ADA2) deficiency.

    Case Presentation: We describe two siblings with early-onset recurrent strokes, arthritis, oral ulcers, discoid rash, peripheral vascular occlusive disease and high antinuclear antibody titers. Read More

    Eruptive Keratoacanthoma-Like Discoid Lupus Erythematosus.
    Am J Dermatopathol 2017 Aug 9. Epub 2017 Aug 9.
    Departments of *Dermatology, and †Pathology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY.
    Hypertrophic discoid lupus erythematosus can resemble keratoacanthoma histomorphologically. We describe a unique case of eruptive keratoacanthomatous scaly papules in a 56-year-old woman with discoid lupus erythematosus. We review the literature and conclude by discussing important histologic features and useful immunostains to consider when attempting to discern the underlying identity and pathogenicity of such lesions. Read More

    Elastic Staining in Differentiating Between Follicular Streamers and Follicular Scars in Horizontal Scalp Biopsy Sections.
    Am J Dermatopathol 2018 Apr;40(4):254-258
    Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
    Background: Accurate identification of follicular streamers versus follicular scars on horizontal scalp biopsy sections is important to differentiate between cicatricial and noncicatricial alopecias. However, distinguishing between them can be difficult especially in nonoptimal specimens. The utility of elastic Verhoeff-Van Gieson (EVG) stain in cicatricial alopecias has been described on vertical sections, but its evaluation on horizontal sections has not been performed. Read More

    Direct antiglobulin (Coombs) test in systemic lupus erythematosus patients.
    Clin Rheumatol 2017 Sep 31;36(9):2141-2144. Epub 2017 Jul 31.
    Medicine Department, Evangelic University, R. Padre Agostinho, 2770, Curitiba, Paraná, 80730-000, Brazil.
    The objective of the study is to study the positivity of Coombs test or direct antiglobulin test (DAT) in systemic lupus erythematosus (SLE) patients and its relationship with disease's clinical and serological profile. Retrospective study of 373 SLE patients seen at single Rheumatology Unit. Epidemiological data (age, gender, age at disease onset, auto declared ethnic background and tobacco use), clinical (malar rash, photosensitivity, oral ulcers, discoid lesions, serositis, glomerulonephritis, convulsions, psychosis, hemolytic anemia, leukopenia, lymphocytopenia and arthritis), and serological profile (anti ds DNA, anti Ro/SS-A; anti La/SS-B, Anti RNP, Anti Sm, aCl (anticardiolipin) IgG, aCl Ig M, LA or lupus anticoagulant, rheumatoid factor and direct Coombs) were collected. Read More

    The Cutaneous Spectrum of Lupus Erythematosus.
    Clin Rev Allergy Immunol 2017 Dec;53(3):291-305
    Dermatologic Clinic, Faculty of Medicine, University of Strasbourg, Strasbourg, France.
    Systemic lupus erythematosus is a complex autoimmune disease with a wide spectrum of clinical and immunopathological features. Cutaneous and articular manifestations are the most common signs in patients with systemic lupus erythematosus. We here review the pathogenesis and the new classification of cutaneous lupus erythemathosus with a discussion of the significance of the various cutaneous signs. Read More

    Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma.
    Skinmed 2017 1;15(3):218-220. Epub 2017 Jun 1.
    Department of Dermatology, Mayo Clinic, Rochester, MN.
    A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs. Read More

    Reflectance confocal microscopic evaluation of nonmelanocytic lip lesions.
    Lasers Med Sci 2017 Sep 5;32(7):1497-1506. Epub 2017 Jul 5.
    Department of Dermatology, Süleymaniye Gynecology and Maternity Training and Research Hospital, İstanbul, Turkey.
    Lips display various benign and malignant lesions. Considering their functional and cosmetic importance, noninvasive diagnostic methods are required. In vivo reflectance confocal microscopy (RCM) has already been reported to be useful in the evaluation of various skin lesions. Read More

    Genetic similarities and differences between discoid and systemic lupus erythematosus patients within the Polish population.
    Postepy Dermatol Alergol 2017 Jun 29;34(3):228-232. Epub 2017 May 29.
    Division of Molecular and Forensic Genetics, Department of Forensic Medicine, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
    Introduction: Many studies have shown that some SNPs might be a risk factor for systemic lupus erythematosus (SLE), but little is known about potential susceptibility loci of the skin types of the disease. Discoid lupus erythematosus (DLE) is the most common form of the cutaneous lupus erythematosus. Nevertheless, a genetic contribution to DLE is not fully recognized. Read More

    Diagnostic value of immunohistochemistry staining of Bcl-2, CD34, CD20 and CD3 for distinction between discoid lupus erythematosus and lichen planus in the skin.
    Indian J Pathol Microbiol 2017 Apr-Jun;60(2):172-176
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    Background: Cluster of differentiation (CD) markers is a classification system for monoclonal antibodies against cell surface molecules on leukocytes and antigens from other cells.

    Aims: The aim of this study is to evaluate immunohistochemical markers in patients with discoid lupus erythematosus (DLE) and lichen planus (LP) and correlation of these markers in two groups and with the normal group in the West of Iran.

    Settings And Design: Analytical cross-sectional study. Read More

    Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome.
    Intern Med 2017 15;56(12):1581-1583. Epub 2017 Jun 15.
    Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan.
    A 35-year-old woman with discoid lupus erythematosus (DLE) was admitted at 11 weeks' gestation with a persistent fever. Laboratory studies revealed pancytopenia, elevated liver enzymes, and hyperferritinemia. Bone marrow aspiration confirmed the diagnosis of hemophagocytic syndrome (HPS). Read More

    Histologic features of chronic cutaneous lupus erythematosus of the scalp using horizontal sectioning: Emphasis on follicular findings.
    J Am Acad Dermatol 2017 Aug 16;77(2):349-355. Epub 2017 Jun 16.
    Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address:
    Background: Chronic cutaneous lupus erythematosus (CCLE) often affects the scalp resulting in scarring alopecia. While histopathologic findings of CCLE have been well described, there is little written on the morphologic changes to the hair follicles in this condition.

    Objective: We aim to determine the histopathologic findings of hair follicles in CCLE of the scalp. Read More

    Development of classification criteria for discoid lupus erythematosus: Results of a Delphi exercise.
    J Am Acad Dermatol 2017 Aug 9;77(2):261-267. Epub 2017 Jun 9.
    Harvard Medical School, Boston, Massachusetts; Division of Rheumatology, Departments of Dermatology and Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:
    Background: No classification criteria currently exist for discoid lupus erythematosus (DLE), which has led to problematic heterogeneity in both observational and interventional research efforts.

    Objectives: We sought to develop DLE classification criteria based on consensus of international expert opinion of relevant stakeholders in the field.

    Methods: Using a Delphi consensus process and nominal group techniques, potential items for classification criteria were generated. Read More

    Effect of ethnicity on clinical presentation and risk of antiphospholipid syndrome in Roma and Caucasian patients with systemic lupus erythematosus: a multicenter cross-sectional study.
    Int J Rheum Dis 2017 Jun 7. Epub 2017 Jun 7.
    Department of Internal Medicine, Complejo Hospitalario Universitario de Granada, Granada, Spain.
    Aim: To determine if there are ethnic differences in the prevalence of antiphospholipid syndrome (APS), clinical presentation and autoantibody profile between Roma and Caucasian patients with systemic lupus erythematosus (SLE).

    Method: A cross-sectional study was conducted including data from Roma and Caucasian SLE patients consecutively attending six hospitals in Spain. Socio-demographic characteristics, prevalence of APS, clinical and analytical features of SLE and APS were compared between ethnic groups. Read More

    Intense Pulsed Light and Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment for the Scarring Lesion of Discoid Lupus Erythematosus.
    Ann Dermatol 2017 Jun 11;29(3):331-333. Epub 2017 May 11.
    Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
    Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus that can cause permanent scarring. Treatment of DLE includes protection from sunlight and artificial sources of ultraviolet light, as well as systemic and topical medications. The first-line standard therapies are antimalarials and topical steroids. Read More

    The Increased Expression of Toll-Like Receptor 4 in Renal and Skin Lesions in Lupus Erythematosus.
    J Histochem Cytochem 2017 07 22;65(7):389-398. Epub 2017 May 22.
    Immunology Department, Habib Bourguiba Hospital (NE, RF, OA, MBJ, HM), University of Sfax, Sfax, Tunisia.
    Toll-like receptor 4 (TLR-4), a bacterial lipopolysaccharide sensor, is an innate immunity essential modulator. It is expressed on both immune and non-immune cells and may contribute to the cutaneous and renal manifestations during lupus erythematosus (LE). Our purpose is to evaluate TLR-4 expression and analyzing its role in lupus nephritis (LN) and chronic cutaneous lupus erythematosus (CLE) pathogenesis. Read More

    Anti-glomerular basement membrane disease accompanied by systemic lupus erythematosus presenting central nervous system involvement.
    CEN Case Rep 2017 May 27;6(1):1-4. Epub 2016 Aug 27.
    Hokkaido Renal Pathology Center, Sapporo IT Front Building #196 N9 W15, Chuo-ku, Sapporo, Hokkaido, 0600009, Japan.
    We report a case of rapidly progressive glomerulonephritis caused by anti-glomerular basement membrane (GBM) disease accompanied by systemic lupus erythematosus (SLE) presenting central nervous system involvement in a 32-year-old Japanese male. He was admitted to our hospital because of a 3-week history of fever and rapidly failing renal function requiring hemodialysis (HD). Laboratory tests showed anti-GBM antibody elevation with a value of 16,385 units/ml. Read More

    Classifying discoid lupus erythematosus: background, gaps, and difficulties.
    Int J Womens Dermatol 2017 Mar 16;3(1 Suppl):S62-S66. Epub 2017 Feb 16.
    Corporal Michael J. Crescenz VAMC (Philadelphia), Philadelphia, PA.
    To inform our ongoing efforts to develop defining features to be incorporated into a novel set of classification criteria for discoid lupus erythematosus (DLE), we conducted a literature review using the Ovid MEDLINE database. A search was performed to identify studies reporting criteria used to distinguish DLE from other cutaneous lupus erythematosus subtypes. We examined which clinical, histopathologic, and serologic features have data to support their use as effective features in distinguishing DLE from other potential disease mimickers and cutaneous lupus subsets. Read More

    Pathogenesis of cutaneous lupus erythema associated with and without systemic lupus erythema.
    Autoimmun Rev 2017 Jul 5;16(7):735-742. Epub 2017 May 5.
    Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address:
    Cutaneous lupus erythematosus (CLE) can be an individual disease only involving skin, or presents as part of the manifestations of SLE. A small proportion of CLE may progress into SLE, however, the underlying pathogenic mediators remain elusive. By only including researches that clearly described if the subtypes of CLE presented by enrolled subjects was associated with or without SLE, we provided an overview of antibodies, inflammatory cells and inflammatory molecular mediators identified in blood and skin that were possibly involved in lupus skin damages. Read More

    Clinical and immunological characteristics of 150 systemic lupus erythematosus patients in Jamaica: a comparative analysis.
    Lupus 2017 Nov 8;26(13):1448-1456. Epub 2017 May 8.
    1 Department of Medicine, University of the West Indies, Mona, Jamaica.
    Background Epidemiological studies in systemic lupus erythematosus have been reported in the literature in many countries and ethnic groups. Although systemic lupus erythematosus in Jamaica has been described in the past, there has not been a detailed evaluation of systemic lupus erythematosus patients in urban Jamaica, a largely Afro-Caribbean population. The goal of this study was to describe the clinical features, particularly disease activity, damage index and immunological features, of 150 systemic lupus erythematosus subjects. Read More

    Ultraviolet-A1 irradiation therapy for systemic lupus erythematosus.
    Lupus 2017 Oct 8;26(12):1239-1251. Epub 2017 May 8.
    Veterans Administration, New Orleans, LA, USA.
    Systemic lupus erythematosus (lupus, SLE) is a chronic autoimmune disease characterized by the production of autoantibodies, which bind to antigens and are deposited within tissues to fix complement, resulting in widespread systemic inflammation. The studies presented herein are consistent with hyperpolarized, adenosine triphosphate (ATP)-deficient mitochondria being central to the disease process. These hyperpolarized mitochondria resist the depolarization required for activation-induced apoptosis. Read More

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