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    Clindamycin-induced Maculopapular Exanthema with Preferential Involvement of Striae Distensae: A Koebner phenomenon?
    Acta Dermatovenerol Croat 2018 Apr;26(1):61-63
    Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;
    Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

    Disease severity and prophylactic measures in patients with cutaneous lupus erythematosus: results of a worldwide questionnaire-based study.
    Postepy Dermatol Alergol 2018 Apr 24;35(2):192-198. Epub 2018 Apr 24.
    Department of Dermatology, University of Rzeszow, Rzeszow, Poland.
    Introduction: Due to a wide array of dermatologic manifestations, assessment of disease severity in cutaneous lupus erythematosus (CLE) remains challenging. Given a need for some standardization in this field, we conducted a worldwide questionnaire-based study among physicians experienced in CLE management.

    Aim: We asked about CLE assessment, their prophylactic measures advised to patients, and treatment recommendations. Read More

    Coexistence of chronic cutaneous lupus erythematosus and frontal fibrosing alopecia.
    An Bras Dermatol 2018 Mar;93(2):274-276
    Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Lupus erythemathosus is a chronic, relapsing disease with acute, subacute, and chronic lesions. Effluvium telogen occurs in the setting of systemic activity of the disease, and cicatricial alopecia results from discoid lesionsin on the scalp. Other types of alopecia, like alopecia areata, may rarely be found in lupus. Read More

    Maximizing the clinical utility of descriptive lymphoid pathology reporting.
    Semin Cutan Med Surg 2018 Mar;37(1):75-80
    Pathology and Dermatology, UCSF Dermatopathology and Oral Pathology Service, University of California, San Francisco, San Francisco, California, USA.
    Dermatopathology reporting can be both exact and inexact. Exact reporting represents the use of terminology that corresponds to a disease sui generis, such as discoid lupus erythematosus or disseminated superficial porokeratosis. Inexact reporting can vary greatly amongst various practitioners-both in terms of the exact semantics used and also stylistically-and can be used habitually by pathologists as a means to provide cover for diagnostic uncertainty or inexperience. Read More

    Clinical and dermoscopic spectrum of discoid lupus erythematosus: novel observations from lips and oral mucosa.
    Int J Dermatol 2018 Apr 27. Epub 2018 Apr 27.
    Dermatology, Venereology & Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Background: Under dermoscopy, discoid lupus erythematosus (DLE) exhibits specific findings. Commonly DLE lesions affect sun-exposed sites, especially the face. However, most of the dermoscopic reports come from scalp DLE. Read More

    Pulsed-dye laser as an adjuvant treatment for discoid lupus erythematosus: a randomized, controlled trial.
    J Dermatolog Treat 2018 May 10:1-6. Epub 2018 May 10.
    a Division of Dermatology, Department of Medicine, Faculty of Medicine , Skin and Allergy Research Unit, Chulalongkorn University , Bangkok , Thailand.
    Purpose: To evaluate the efficacy and safety of pulsed-dye laser (PDL) for discoid lupus erythematosus (DLE) in a double blinded, randomized, controlled fashion.

    Method: Forty-eight DLE lesions from nine patients were recruited. The lesions on one side of the body were randomized into the treatment group and the other side served as a control. Read More

    Cutaneous lupus erythematosus in dogs: a comprehensive review.
    BMC Vet Res 2018 Apr 18;14(1):132. Epub 2018 Apr 18.
    Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
    Since the first description of discoid lupus erythematosus (LE) in two dogs in 1979, the spectrum of canine cutaneous lupus erythematosus (CLE) variants has expanded markedly.In this review, we first propose an adaptation of the Gilliam-Sontheimer classification of CLE for dogs. We then review the signalment, clinical signs, laboratory and histopathology and treatment outcome of the currently recognized variants of canine CLE, which are vesicular CLE, exfoliative CLE, mucocutaneous LE and facial or generalized discoid LE. Read More

    Racial Disparities in the Incidence of Primary Chronic Cutaneous Lupus Erythematosus in the Southeastern United States: The Georgia Lupus Registry.
    Arthritis Care Res (Hoboken) 2018 Apr 18. Epub 2018 Apr 18.
    Emory University, Department of Medicine, Division of Rheumatology, Atlanta, Georgia, US.
    Objective: Relative to SLE, epidemiologic studies on chronic cutaneous lupus erythematosus (CCLE) are rare and limited to populations without racial diversity. We sought to provide minimum estimates of the incidence of primary CCLE (CCLE in absence of SLE) in a predominantly white and black population in the Southestern United States.

    Methods: The Georgia Lupus Registry used multiple sources for case finding, including dermatology and rheumatology practices, multispecialty healthcare facilities, and dermatopathology reports. Read More

    A case report of lupus erythematosus tumidus converted from discoid lupus erythematosus.
    Medicine (Baltimore) 2018 Apr;97(16):e0375
    Department of Dermatology, West China Hospital of Sichuan University, Chengdu, China.
    Rationale: Lupus erythematosus tumidus (LET) is an uncommon type of cutaneous lupus erythematosus (CLE) that is rarely associated with other forms of lupus erythematosus.

    Patient Concerns: We report a 62-year-old Chinese man presented with recurrent erythematous facial plaques for 1 year and a low-grade fever for 1 week. He had been diagnosed as discoid lupus erythematosus (DLE) 1 year before. Read More

    Steroid-Induced Psychosis in the Pediatric Population: A New Case and Review of the Literature.
    J Child Adolesc Psychopharmacol 2018 Apr 11. Epub 2018 Apr 11.
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine , Miami, Florida.
    Objectives: Iatrogenic steroid-induced psychosis is a rare but serious adverse side effect seen largely in the adult population that less commonly affects children and adolescents. Given the significant distress steroid-induced psychosis may cause, recommendations are needed for effective management. Here we conducted a systematic review of the literature and report a new case of steroid-induced psychosis in a 12-year-old patient. Read More

    Combined mepacrine-hydroxychloroquine treatment in patients with systemic lupus erythematosus and refractory cutaneous and articular activity.
    Lupus 2018 Jan 1:961203318768877. Epub 2018 Jan 1.
    1 Autoimmune Diseases Research Unit, Department of Internal Medicine, Biocruces, 16494 Hospital Universitario Cruces , UPV/EHU Bizkaia, The Basque Country, Spain.
    Aim The aim of this study was to evaluate the clinical response to combined therapy with hydroxychloroquine and mepacrine in patients with systemic lupus erythematosus and refractory joint and/or skin disease. Methods Mepacrine was added to 46 systemic lupus erythematosus patients unresponsive to treatment with the following drug combinations: hydroxychloroquine + prednisone + immunosuppressive drugs ( n = 24), hydroxychloroquine + prednisone ( n = 16), hydroxychloroquine + prednisone + retinoids ( n = 2), hydroxychloroquine alone ( n = 1), hydroxychloroquine + one immunosuppressive drug ( n = 1), hydroxychloroquine + prednisone + one immunosuppressive drug + belimumab ( n = 1) or hydroxychloroquine + prednisone + belimumab ( n = 1). The outcome variable was the clinical response, either complete or partial, based on clinical judgement. Read More

    X-linked TLR7 gene polymorphisms are associated with diverse immunological conditions but not with discoid lupus erythematosus in Polish patients.
    Postepy Dermatol Alergol 2018 Feb 20;35(1):26-32. Epub 2018 Feb 20.
    Division of Molecular and Forensic Genetics, Department of Forensic Medicine, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
    Introduction: Toll-like receptor 7 (TLR7) is an important molecule involved in the development of autoimmunity and the response to different pathogens. Several polymorphisms within the gene were previously found to be associated with systemic lupus erythematosus (SLE). However, none of those studies investigated the promoter flanking variants rs1634318 and rs1616583. Read More

    A 22-year-old woman with systemic lupus erythematosus presents with two damaged kidneys, one seizure, no platelets, and many possible diagnoses.
    Arthritis Care Res (Hoboken) 2018 Mar 26. Epub 2018 Mar 26.
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH.
    A 22-year-old woman with a history of systemic lupus erythematosus (SLE) was admitted with progressive edema. Two years before hospitalization, a local rheumatologist diagnosed her with SLE based on a syndrome of oral ulcers, inflammatory arthritis, discoid lupus lesions, and Raynaud phenomenon. Serum analysis revealed high-titer anti-nuclear antibodies, the presence of anti-SSA, anti-SSB, anti-Smith, anti-RNP, anti-histone, and anti-double-stranded DNA antibodies, and low complement (C3 and C4) levels. Read More

    Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity.
    Sci Rep 2018 Feb 22;8(1):3462. Epub 2018 Feb 22.
    Department of Rheumatology, 1st Affiliated Hospital of China Medical University, Shen Yang, China.
    We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM, anti-double-stranded DNA antibody (Anti-dsDNA Ab) and hemoglobin (Hb) levels and white blood cell (WBC) and platelet (PLT) counts, were performed using standard methods. Lupus nephritis (LN) was diagnosed according to the American College of Rheumatology (ACR) renal criteria. Read More

    Jessner lymphocytic infiltration - rare in childhood.
    Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.
    Department of Dermatology and Allergy Centre, Odense University Hospital, Denmark.
    We present a 13-year-old girl with Jessner lymphocytic infiltrate of the skin, who has suffered from the disease since the age of 9 years. It is a rare disease in childhood, and we highlight the clinical features and therapeutic response of tacrolimus. Read More

    Lupus and scleroderma overlap features in a 28-year-old man with anti-PL-12 anti-synthetase syndrome.
    Dermatol Online J 2017 Sep 15;23(9). Epub 2017 Sep 15.
    Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
    A 28-year-old man with clinically and laboratory diagnosed anti-PL-12 anti-synthetase syndrome (AS) in 2009 developed cutaneous lupus lesions, discoid lupus lesions, and sclerodacytly with finger-tip ulcerations four years following his AS diagnosis. Laboratory tests including +ANA, +anti-dsDNA antibody, +anti-Smith antibody, and +anti-RNP antibody in 2014 confirmed the diagnosis of progression to an overlap syndrome including systemic lupus erythematosus. The patient now also has clinical findings (sclerodacytly, Raynaud phenomenon, finger-tip ulcerations) consistent with scleroderma overlap. Read More

    The lupus patient with positive rheumatoid factor.
    Lupus 2018 Jan 1:961203318759607. Epub 2018 Jan 1.
    1 Rheumatology Service, Evangelical University Hospital of Curitiba, Curitiba, Brazil.
    Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study of 467 SLE patients seen at a single rheumatology unit was conducted. Read More

    The use of SLICC and ACR criteria to correctly label patients with cutaneous lupus and systemic lupus erythematosus.
    Clin Rheumatol 2018 Mar 1;37(3):817-818. Epub 2018 Feb 1.
    Dermatology Department, St. James's Hospital, Dublin, Ireland.
    The American College of Rheumatology (ACR) classification criteria for lupus and Systemic Lupus International Collaborating Clinics (SLICC) criteria are designed to classify disease. However, they have become widely used as diagnostic criteria in clinical situations. Patients may be labelled as systemic lupus erythematosus (SLE) in their medical records, when in fact they have cutaneous lupus erythematosus (CLE) without systemic symptoms. Read More

    Primary cutaneous anaplastic large-cell lymphoma: A case report.
    Medicine (Baltimore) 2018 Jan;97(4):e9645
    Rationale: Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare cancer belonging to the group of primary T-cell lymphoproliferative diseases. C-ALCL is characterized by the presence of single or multiple ulcerated lesions on the skin's surface.

    Patient Concerns: This is the case of a 73-year-old man who reported to the Clinic of Cranio-Maxillofacial and Oral Surgery and Implantology, Medical University of Warsaw, owing to a skin tumor in the right parotideomasseteric region, initially diagnosed as discoid lupus erythematosus. Read More

    Primary scarring alopecia: A retrospective study of 89 patients in Taiwan.
    J Dermatol 2018 Apr 16;45(4):450-455. Epub 2018 Jan 16.
    Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
    Primary scarring alopecia (PSA) is caused by irreversible damage to the hair epithelial stem cells that reside in hair follicles. There is limited published work regarding PSA amongst the Asian population. The aim of this study was to evaluate the clinical features and to characterize the subtypes of PSA in southern Taiwan. Read More

    Computerized planimetry to assess clinical responsiveness in a phase II randomized trial of topical R333 for discoid lupus erythematosus.
    Br J Dermatol 2018 Jan 16. Epub 2018 Jan 16.
    Corporal Michael J. Crescenz Veterans Affairs Medical Center (Philadelphia), Philadelphia, PA, U.S.A.
    Background: R333 is a topical janus kinase and spleen tyrosine kinase inhibitor being evaluated for discoid lupus erythematosus (DLE) treatment. There is no validated measure to assess the area of active DLE lesions.

    Objectives: To evaluate R333 efficacy and assess a technique to measure responsiveness. Read More

    Individuals living with lupus: findings from the LUPUS UK Members Survey 2014.
    Lupus 2018 Apr 8;27(4):681-687. Epub 2018 Jan 8.
    1 Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
    Systemic lupus erythematosus (SLE) is a complex and unpredictable disease which varies greatly among patients and has a significant impact on an individual's daily living and quality of life. A better understanding of the patients' experiences with the disease is vital to the effective management of the disease. LUPUS UK, a national UK-registered charity supporting people with systemic and discoid lupus, conducted a UK-wide survey of individuals living with lupus in order to provide foundation information to support and identify gaps needing further research. Read More

    Naked Hair Shafts as a Marker of Cicatricial Alopecia.
    Am J Dermatopathol 2017 Dec 28. Epub 2017 Dec 28.
    Departments of Dermatology, and.
    Naked hair shafts (NHS) are free-floating hair shafts devoid of surrounding epithelium, supporting structures, and/or embedded in inflammation that may result from destruction of hair follicles by scarring processes such as inflammation and fibroplasia. Extensive examination of NHS has not been performed in scalp biopsies of alopecia. We retrospectively evaluated 622 scalp biopsies of alopecia [345 cicatricial alopecias (central centrifugal cicatricial alopecia, lichen planopilaris, discoid lupus erythematosus, acne keloidalis nuchae, and folliculitis decalvans] and 277 non-cicatricial alopecias [alopecia areata, androgenic alopecia, telogen effluvium, and psoriatic alopecia)] for the presence of NHS. Read More

    White rosettes in discoid lupus erythematosus: a new dermoscopic observation.
    Dermatol Pract Concept 2017 Oct 31;7(4):9-11. Epub 2017 Oct 31.
    BLDE University's Shri M B Patil Medical College, Vijayapura, India.
    White rosettes are shiny white structures seen as four oval-shaped points that come together in the center. They resemble four-leaf clover [1]. Earlier it was thought they were specific for actinic keratosis and squamous cell carcinoma, but they are noted in many other conditions [2]. Read More

    Blue-White Veil as Novel Dermatoscopic Feature in Discoid Lupus Erythematosus in 2 African-American Patients.
    Skin Appendage Disord 2017 Oct 10;3(4):211-214. Epub 2017 Jun 10.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
    Dermoscopic features of discoid lupus erythematosus (DLE) depend on the stage of the lesions: active lesions include yellow-brown dots and red dots, whereas longstanding inactive lesions show absence of follicular openings, cicatricial milky red or white patches, structureless white and brown areas, and thick arborizing vessels. Loss of pinpoint white dots, blue-gray dots in a speckled pattern, and a peripheral pigmented network have been described on dermoscopy of DLE in dark skin. We report a blue-white veil as a novel dermoscopic feature in 2 cases of biopsy-proven DLE in African-American patients. Read More

    Yellow dots in trichoscopy: relevance, clinical significance and peculiarities.
    An Bras Dermatol 2017 Sep-Oct;92(5):724-726
    Alopecia Outpatient Clinic at Hospital Naval Marcílio Dias (HNMD) - Rio de Janeiro (RJ), Brazil.
    Yellow dots are follicular ostium filled with keratin and/or sebum. Initially, they were exclusively associated with alopecia areata. Currently they have also been described in androgenetic alopecia, chronic cutaneous (discoid) lupus erythematosus, and dissecting cellulitis. Read More

    A rare case of unilateral discoid lupus erythematosus mimicking lupus vulgaris.
    BMJ Case Rep 2017 Nov 8;2017. Epub 2017 Nov 8.
    Department of Dermatology, Delhi Dermpath Laboratory, New Delhi, India.
    Discoidlupus erythematosus (DLE) is a chronic type of cutaneous lupus erythematosus which can present in various morphologies, and the diagnosis can be rather confounding. Prompt evaluation and treatment is necessary to prevent disfigurement and systemic involvement associated with DLE. The following case presented a diagnostic dilemma as the lesion mimicked lupus vulgaris. Read More

    Monogenic interferonopathies: Phenotypic and genotypic findings of CANDLE syndrome and its overlap with C1q deficient SLE.
    Int J Rheum Dis 2018 Jan 8;21(1):208-213. Epub 2017 Nov 8.
    Department of Allergy and Immunology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
    Objective: To report the clinical and genetic features of the first cases of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome in an Arab population and to compare them with patients of C1q deficient systemic lupus erythematosus (SLE).

    Materials And Methods: This is a retrospective case series of patients with CANDLE syndrome and C1q deficient SLE seen at a single tertiary hospital. Medical records were reviewed for demographic data, clinical and laboratory features, histopathology and imaging findings, and response to therapeutic intervention. Read More

    Dramatic effect of hydroxychloroquine on lupus alopecia.
    J Dermatol 2018 Feb 25;45(2):194-197. Epub 2017 Oct 25.
    Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
    Lupus alopecia is usually difficult to treat. We report a case of a 40-year-old woman with Sjögren's syndrome and atopic dermatitis who presented with discoid lupus erythematosus on the forearms and lupus erythematosus profundus with alopecia involving the scalp. A biopsy specimen taken from the discoid lupus erythematosus lesion on the forearm further exhibited a xanthomatous reaction, which however was not detected in another specimen from the lupus erythematosus profundus on the scalp. Read More

    Initial digital vasculitis in a large multicenter cohort of childhood-onset systemic lupus erythematosus.
    Rev Bras Reumatol Engl Ed 2017 Nov - Dec;57(6):583-589. Epub 2017 Oct 16.
    Universidade Federal de São Paulo (UNIFESP), Unidade de Reumatologia Pediátrica, São Paulo, SP, Brazil. Electronic address:
    Objectives: To assess clinical digital vasculitis (DV) as an initial manifestation of childhood-onset systemic lupus erythematosus (cSLE) within a large population.

    Methods: Multicenter cross-sectional study including 852 cSLE patients (ACR criteria) followed in ten Pediatric Rheumatology centers in São Paulo State, Brazil.

    Results: DV was observed in 25/852 (3%) cSLE patients. Read More

    Multiple primary squamous cell carcinomas of the lower lip and tongue arising in discoid lupus erythematosus: a case report.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Feb 30;125(2):e22-e30. Epub 2017 Aug 30.
    Department of Oral Pathology and Medicine, School of Dentistry, National and Kapodistrian University of Athens, Greece.
    Squamous cell carcinoma (SCC) developing in lesions of discoid lupus erythematosus (DLE) is rare, most frequently arising on sun-exposed skin and very rarely affecting the lips. A review of the English language literature revealed only 21 published cases of labial SCC in patients with DLE. Here, an unusual case of a patient with DLE who developed 3 primary SCCs of the oral and perioral region is presented. Read More

    Not Just Skin Deep: Systemic Disease Involvement in Patients With Cutaneous Lupus.
    J Investig Dermatol Symp Proc 2017 Oct;18(2):S69-S74
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:
    Cutaneous lupus erythematosus, specifically discoid lupus erythematosus, disproportionately affects those with skin of color and may result in greater dyspigmentation and scarring in darker skin types. In this article, we review investigations relevant to cutaneous lupus patients with skin of color at University of Texas Southwestern Medical Center, associations and risk of progression to systemic lupus, and recommendations for monitoring for systemic disease spread. Between 5% and 25% of patients with cutaneous lupus can develop systemic lupus. Read More

    Primary Idiopathic Pseudopelade of Brocq in a Young Child.
    Int J Trichology 2017 Jul-Sep;9(3):113-115
    Department of Leprosy, Pramukshwami Medical College, Karamsad, Gujarat, India.
    Pseudopelade of Brocq (PPB) is a rare, chronic, slowly progressive cicatricial alopecia that generally affects middle-aged women. Vertex and parietal scalp are commonly involved. It can be primary or secondary to end stage of other scarring alopecia such as lichen planopilaris and discoid lupus erythematosus. Read More

    Discoid Lupus Erythematosus Presenting as Upper Eyelid Edema and Erythema.
    Acta Med Iran 2017 Jul;55(7):474-476
    Department of Dermatology, Skin Research Center, Guilan University of Medical Sciences, Rasht, Iran.
    Discoid Lupus Erythematosus (DLE) is an autoimmune disorder that usually occurs on sun exposed areas of head and neck. Infrequently it could be presented by palpebral involvement and rarely unilateral upper eye lid edema and erythema have been reported as the sole manifestation of DLE. We describe a 38-year-old woman with chronic left upper eye lid edema and erythema from one year ago which was induced by steroid injection for left eyebrow alopecia. Read More

    Steady-state pharmacokinetics of hydroxychloroquine in patients with cutaneous lupus erythematosus.
    Lupus 2018 Apr 1;27(5):847-852. Epub 2017 Sep 1.
    4 University Hospital of North Durham, Department of Dermatology, North Road Durham, DH1 5TW, Institute of Cellular Medicine, 5994 Newcastle University , UK.
    Background Hydroxychloroquine (HCQ), a 4-aminoquinolone antimalarial, is regarded as the oral therapy of choice for cutaneous and systemic lupus erythematosus (SLE). It is also licensed for rheumatoid arthritis (RA). Studies of HCQ-treated patients with SLE or RA have demonstrated a positive correlation between whole-blood HCQ levels and clinical response. Read More

    Chronic cutaneous lupus erythematosus presenting as atypical acneiform and comedonal plaque: case report and literature review.
    Lupus 2018 Apr 31;27(5):853-857. Epub 2017 Aug 31.
    Hospital do Servidor Público Municipal de São Paulo (HSPM), São Paulo, Brazil.
    Introduction Chronic cutaneous lupus erythematosus (CCLE) usually presents as characteristic erythematous patches and infiltrated coin-shaped plaques. However, there are some atypical clinical variants that may mimic other dermatological conditions. Haroon et al. Read More

    Autoimmune phenotype with type I interferon signature in two brothers with ADA2 deficiency carrying a novel CECR1 mutation.
    Pediatr Rheumatol Online J 2017 Aug 22;15(1):67. Epub 2017 Aug 22.
    Department of Pediatrics, Medical Faculty, Technical University Dresden, Dresden, Germany.
    Background: Loss-of-function CECR1 mutations cause polyarteritis nodosa (PAN) with childhood onset, an autoinflammatory disorder without significant signs of autoimmunity. Herein we describe the unusual presentation of an autoimmune phenotype with constitutive type I interferon activation in siblings with adenosine deaminase 2 (ADA2) deficiency.

    Case Presentation: We describe two siblings with early-onset recurrent strokes, arthritis, oral ulcers, discoid rash, peripheral vascular occlusive disease and high antinuclear antibody titers. Read More

    Eruptive Keratoacanthoma-Like Discoid Lupus Erythematosus.
    Am J Dermatopathol 2018 Jun;40(6):423-427
    Pathology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY.
    Hypertrophic discoid lupus erythematosus can resemble keratoacanthoma histomorphologically. We describe a unique case of eruptive keratoacanthomatous scaly papules in a 56-year-old woman with discoid lupus erythematosus. We review the literature and conclude by discussing important histologic features and useful immunostains to consider when attempting to discern the underlying identity and pathogenicity of such lesions. Read More

    Elastic Staining in Differentiating Between Follicular Streamers and Follicular Scars in Horizontal Scalp Biopsy Sections.
    Am J Dermatopathol 2018 Apr;40(4):254-258
    Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
    Background: Accurate identification of follicular streamers versus follicular scars on horizontal scalp biopsy sections is important to differentiate between cicatricial and noncicatricial alopecias. However, distinguishing between them can be difficult especially in nonoptimal specimens. The utility of elastic Verhoeff-Van Gieson (EVG) stain in cicatricial alopecias has been described on vertical sections, but its evaluation on horizontal sections has not been performed. Read More

    Chinese lupus treatment and research group (CSTAR) registry: X. family history in relation to lupus clinical and immunological manifestations.
    Clin Exp Rheumatol 2018 Jan-Feb;36(1):81-87. Epub 2017 Jul 7.
    Department of Rheumatology, Peking Union Medical College Hospital, and Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
    Objectives: This study aimed to examine the associations between family history and clinical manifestations and immunologic characteristics of lupus in China.

    Methods: Based on their family history, lupus patients from the Chinese lupus treatment and research group (CSTAR) registry were categorised: familial lupus (FL), family history of other rheumatic disorders (RD), and sporadic lupus (SL). Demographic data, clinical manifestations, and laboratory data were compared among these three groups. Read More

    Direct antiglobulin (Coombs) test in systemic lupus erythematosus patients.
    Clin Rheumatol 2017 Sep 31;36(9):2141-2144. Epub 2017 Jul 31.
    Medicine Department, Evangelic University, R. Padre Agostinho, 2770, Curitiba, Paraná, 80730-000, Brazil.
    The objective of the study is to study the positivity of Coombs test or direct antiglobulin test (DAT) in systemic lupus erythematosus (SLE) patients and its relationship with disease's clinical and serological profile. Retrospective study of 373 SLE patients seen at single Rheumatology Unit. Epidemiological data (age, gender, age at disease onset, auto declared ethnic background and tobacco use), clinical (malar rash, photosensitivity, oral ulcers, discoid lesions, serositis, glomerulonephritis, convulsions, psychosis, hemolytic anemia, leukopenia, lymphocytopenia and arthritis), and serological profile (anti ds DNA, anti Ro/SS-A; anti La/SS-B, Anti RNP, Anti Sm, aCl (anticardiolipin) IgG, aCl Ig M, LA or lupus anticoagulant, rheumatoid factor and direct Coombs) were collected. Read More

    The Cutaneous Spectrum of Lupus Erythematosus.
    Clin Rev Allergy Immunol 2017 Dec;53(3):291-305
    Dermatologic Clinic, Faculty of Medicine, University of Strasbourg, Strasbourg, France.
    Systemic lupus erythematosus is a complex autoimmune disease with a wide spectrum of clinical and immunopathological features. Cutaneous and articular manifestations are the most common signs in patients with systemic lupus erythematosus. We here review the pathogenesis and the new classification of cutaneous lupus erythemathosus with a discussion of the significance of the various cutaneous signs. Read More

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