Reply: X chromosome short arm involvement in autoimmune diseases: comment on the report by Sharma, et al.
Arthritis Rheumatol 2018 Jan 5. Epub 2018 Jan 5.
Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation.
Studying Klinefelter's syndrome (male 47,XXY) and triple X (female 4,7XXX), we propose that the number of X chromosomes mediates the female bias of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Our recent paper described SLE and SS patients with extremely rare X chromosome aneuploides in which distal Xp was triplicated, implicating genes lying on the short arm of X1 . Brooks points out that X-linked chronic granulomatosus disease (X-CGD) can also have gene duplication from Xp21. Read More