4,020 results match your criteria Lupus Erythematosus Discoid


Current Concepts on Pathogenic Mechanisms and Histopathology in Cutaneous Lupus Erythematosus.

Front Med (Lausanne) 2022 30;9:915828. Epub 2022 May 30.

Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.

Cutaneous lupus erythematosus (CLE) is an interferon (IFN)-driven autoimmune disease that may be limited to the skin or can be associated with systemic lupus erythematosus (SLE). CLE occurs in several morphologic subtypes ranging from isolated, disc-shaped plaques to disseminated skin lesions. The typical histopathologic pattern of skin lesions is named interface dermatitis and characterized by a lymphocytic infiltrate and necroptotic keratinocytes at the dermo-epidermal junction. Read More

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Epidemiological, Clinical, Trichoscopic, and Histopathological Features of Lupus Erythematous Mimicking Alopecia Areata: A Multicenter Retrospective Study.

Skin Appendage Disord 2022 May 3;8(3):236-240. Epub 2022 Jan 3.

Department of Specialized, Experimental and Diagnostic Medicine, Dermatology - IRCCS, Policlinico Sant'Orsola, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Introduction: All types of lupus erythematosus (LE) may cause hair loss. Nonscarring alopecia was correlated with systemic LE, based on its high specificity. Discoid LE can also appear as nonscarring patches in early stages. Read More

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Lupus Erythematosus Tumidus: Clinical and Pathological Features in a Series of 20 Patients.

Am J Dermatopathol 2022 Jul 1;44(7):469-477. Epub 2021 Nov 1.

Passant, Faculty of Engineering, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Objective: We sought to assess the clinicopathologic/immunophenotypical features in patients with lupus erythematosus tumidus (LET).

Methods: All skin biopsies diagnosed as LET in 16 years were retrieved from our pathology laboratory. Clinical charts were reviewed and immunohistochemical markers were performed. Read More

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Discoid Lupus Erythematosus-Associated Cutaneous Squamous Cell Carcinoma in Systemic Lupus Erythematosus.

Eurasian J Med 2022 Jun;54(2):204-205

Ataturk University School of Medicine, Aesthetic, Plastic and Reconstructive Surgery, Erzurum, Turkey.

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Nivolumab-Induced de novo Discoid Lupus Erythematosus.

Case Rep Dermatol 2022 Jan-Apr;14(1):88-92. Epub 2022 Apr 21.

Department of Dermatology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.

An increasing number of checkpoint inhibitor-induced subacute cutaneous lupus erythematosus events have been reported. We present the first case of nivolumab-induced discoid lupus erythematosus in a patient with hepatocellular carcinoma. The patient presents with violaceous hypopigmented plaques on the pinna bilaterally, hypopigmented plaques with central hyperpigmentation on the posterior neck, and other hypopigmented plaques on the face, forearms, and hands. Read More

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Hair and Nail Conditions: Alopecia Evaluation.

Authors:
Sam Wu

FP Essent 2022 Jun;517:11-16

Department of Dermatology - University of North Carolina School of Medicine, 410 Market St Suite 400, Chapel Hill, NC 27516.

Alopecia affects men and women and can result in significant distress for patients. Alopecias can be categorized as nonscarring or scarring. Nonscarring alopecias include male and female pattern alopecias, alopecia areata, telogen effluvium, traction alopecia, trichotillomania, and tinea capitis. Read More

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Late-onset systemic lupus erythematosus associated with inverse discoid lupus erythematosus on the buttock.

JAAD Case Rep 2022 Jun 26;24:115-117. Epub 2022 Apr 26.

Division of Dermatology, University of Arizona, Tucson, Arizona.

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Discoid Lupus.

Cutis 2022 03;109(3):172-173

Family and Community Medicine Professor, Dermatology and Cutaneous Surgery University of Texas Health San Antonio.

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Implications of Dermoscopy and Histopathological Correlation in Discoid Lupus Erythematosus in Skin of Color.

Indian J Dermatol 2022 Jan-Feb;67(1):5-11

Department of Community Medicine, S. Nijalingappa Medical College, Bagalkot, Karnataka, India.

Background: Discoid lupus erythematosus (DLE) is chronic dermatosis manifests as scaly indurated plaques with erythema and peripheral hyperpigmentation. Few cases progress to systemic lupus erythematosus. Differentials include lichenoid photo dermatitis, Jessner's lymphocytic infilterate, and polymorphus light eruptions. Read More

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Dendritic cells may help differentiate discoid lupus erythematosus alopecia from lichen planopilaris.

Postepy Dermatol Alergol 2022 Apr 9;39(2):298-303. Epub 2022 May 9.

Department of Dermatology, University Hospital, Krakow, Poland.

Introduction: Primary cicatricial alopecia (PCA) encompasses a heterogeneous group of inflammatory diseases characterized by the replacement of hair follicle structures by fibrous tissue. Discoid lupus erythematosus (DLE) and lichen planopilaris (LPP) are the most common causes of scarring alopecia. The distinction between both entities is often challenging because of significant clinical and histopathological overlap. Read More

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Prominent B cell signature differentiates discoid from subacute cutaneous lupus erythematosus.

J Invest Dermatol 2022 May 17. Epub 2022 May 17.

Department of Dermatology, University of Rochester Medical Center, Rochester, NY, USA; Department of Medicine, Division of Allergy/Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA. Electronic address:

While B cells account for a significant proportion of the lymphocytic infiltrate in discoid lupus erythematosus (DLE), their contribution to pathogenesis is unknown. In this study, we compare the immune landscape of 17 subjects with DLE to 21 subjects with subacute cutaneous lupus erythematosus (SCLE) using transcriptomic and histologic analyses of lesional skin. A few of the subjects (3/17 DLE, 5/21 SCLE) had concomitant systemic lupus erythematosus (SLE). Read More

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Discoid lupus.

J Fam Pract 2022 03;71(2):E16-E17

Family and Community Medicine, Dermatology and Cutaneous Surgery, University of Texas Health, San Antonio.

THE COMPARISON A Multicolored (pink, brown, and white) indurated plaques in a butterfly distribution on the face of a 30-year-old woman with a darker skin tone. B Pink, elevated, indurated plaques with hypopigmentation in a butterfly distribution on the face of a 19-year-old woman with a lighter skin tone. Read More

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Systemic Lupus Erythematosus vs. Mixed Connective Tissue Disease Disguised As Scabies.

Cureus 2022 Mar 29;14(3):e23621. Epub 2022 Mar 29.

Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that involves numerous body systems and may initially present as a malar or discoid rash. When there are features of other autoimmune disorders present, such as scleroderma or polymyositis, the term mixed connective tissue disorder (MCTD) may be used. The current literature illustrates that the diagnostic criteria for MCTD are unclear. Read More

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The Role of Reflectance Confocal Microscopy in the Evaluation of Pigmented Oral Lesions and Their Relationship With Histopathological Aspects.

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Stomatology, Dental School, University of Sao Paulo, Sao Paulo, Brazil; and.

Abstract: Oral pigmentations are a heterogeneous group and can be the result of physiological activity of oral mucosal melanocytes, secondary to exogenous causes, associated with systemic or local diseases, or due to proliferative activity of melanocytes. Their diagnosis is critical because these lesions can be markers of internal diseases or, in the case of melanocytic proliferative processes, they may represent a malignant neoplasm. In the past decade, the use of reflectance confocal microscopy, a noninvasive imaging tool, has aided the analysis of such lesions, but the establishment of firm criteria in their evaluation is still lacking. Read More

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Cross-sectional characteristics of pediatric-onset discoid lupus erythematosus: Results of a multicenter, retrospective cohort study.

J Am Acad Dermatol 2022 Apr 26. Epub 2022 Apr 26.

Department of Pediatrics, Section of Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background: The incidence of systemic lupus in children with discoid lupus is unknown.

Objective: This study assessed the baseline characteristics of patients with pediatric discoid lupus erythematosus (pDLE).

Methods: Medical records at 17 sites were reviewed for pediatric dermatology and rheumatology patients with discoid lupus erythematosus. Read More

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Discoid lupus erythematosus of the palms: A case report.

Clin Case Rep 2022 Apr 22;10(4):e05048. Epub 2022 Apr 22.

Department of Dermatology University of Maryland School of Medicine Baltimore Maryland USA.

Discoid lupus erythematosus is an autoimmune connective-tissue disease that represents a subset of conditions on the cutaneous lupus spectrum. The lesions are characterized by disk-shaped plaques on photo-exposed skin with inflammatory hyperpigmentation and adherent scale. Here, we present a patient with a rare manifestation of discoid lesions on the palms. Read More

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Orbital myositis in systemic lupus erythematosus: a case-based review.

Rheumatol Int 2022 Apr 19. Epub 2022 Apr 19.

Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, 45110, Ioannina, Greece.

Ocular complications occur in up to one-third of patients with systemic lupus erythematosus (SLE). Among them, orbital myositis (OM) is considered a rare manifestation that affects the extraocular muscles and causes pain and restriction with eye movement. We report a case of OM in a 48-year-old female with SLE and secondary Sjogren's Syndrome, who presented headache, periorbital edema, and painful ocular movements in both eyes, with no other systemic manifestations. Read More

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Aggravation of discoid lupus erythematosus in a patient with psoriasis and psoriatic arthritis during treatment of secukinumab: A case report and review of literature.

Lupus 2022 Jun 19;31(7):891-894. Epub 2022 Apr 19.

Department of Dermatology, 38006National Taiwan University Hospital, Taipei, Taiwan.

Background: The coexistence of psoriasis and cutaneous lupus erythematosus (LE) is uncommon. Treatment for concomitant psoriasis and LE is challenging because some valid treatments for LE such as hydroxychloroquine and systemic corticosteroid are known to aggravate psoriasis. Th17 pathway is shared by these two disease entities. Read More

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Dermoscopy of discoid lupus erythematosus of palms.

J Eur Acad Dermatol Venereol 2022 Apr 16. Epub 2022 Apr 16.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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Dermoscopic Features of Actinic Cheilitis and Other Common Inflammatory Cheilitis: A Multicentric Retrospective Observational Study by the International Dermoscopy Society.

Dermatology 2022 Apr 7:1-6. Epub 2022 Apr 7.

Institute of Dermatology, Santa Maria della Misericordia University Hospital, Udine, Italy.

Background: Clinical differentiation between different cheilitis variants may be difficult. Application of mucoscopy, in addition to clinical background, could provide additional diagnostic clues facilitating initial patient management.

Objectives: To determine mucoscopic clues differentiating actinic cheilitis from the main forms of inflammatory cheilitis, including eczematous cheilitis, discoid lupus erythematosus, and lichen planus of the lips. Read More

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Prevalence and factors associated with long-term remission in cutaneous lupus: A longitudinal cohort study of 141 cases.

J Am Acad Dermatol 2022 Apr 4. Epub 2022 Apr 4.

Sorbonne Université, Faculté de médecine, AP-HP, Service de Dermatologie et Allergologie, Hôpital Tenon, Paris, France. Electronic address:

Background: Little is known about the prevalence and factors associated with long-term remission in cutaneous lupus erythematosus (CLE).

Objectives: To assess the prevalence, the factors associated with remission, and the long-term remission with and without treatment during CLE.

Methods: Longitudinal cohort study including biopsy-proven patients with CLE seen between November 1, 2019 and April 30, 2021, with at least 6 months of follow-up after diagnosis. Read More

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Lupus Erythematosus Tumidus Associated With Hemophagocytosis.

Am J Dermatopathol 2022 Jul 6;44(7):519-522. Epub 2022 Apr 6.

Department of Dermatopathology, St George's University Hospital, London, United Kingdom.

Abstract: A case of lupus erythematosus tumidus (LET), a subtype of chronic cutaneous lupus erythematosus, in an 85-year-old woman who presented with discrete indurated erythematous plaques over the face and upper chest is described. A skin biopsy showed features in keeping with a diagnosis of LET. Unusually however, the lymphocytic infiltrate contained frequent macrophages that demonstrated hemophagocytosis. Read More

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Comparison of clinical presentation and outcome of childhood-onset and adulthood-onset of systemic lupus erythematosus among Indonesian patients.

Lupus 2022 May 5;31(6):759-764. Epub 2022 Apr 5.

Allergy and Immunology Division, Faculty of Medicine, Department of Child Health, 61809Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung, Indonesia.

Introduction: The clinical presentation of childhood-onset systemic lupus erythematosus (SLE) is generally perceived to differ from that of adult-onset SLE.

Objective: We aimed to compare the demographic and clinical manifestation between childhood-onset vs. adult-onset SLE in a cohort of Indonesian patients at tertiary care centers. Read More

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Thalidomide and discoid lupus erythematosus: case series and review of literature.

Drugs Context 2022 16;11. Epub 2022 Mar 16.

CNR-IFC, Section of Clinical Epidemiology and Biostatistics, of Reggio Calabria, Italy.

Background: The anti-inflammatory drug, thalidomide, is often administered off-label especially in dermatology patients with diseases refractory to different medications. The drug's mechanism of action is not well understood but clinical evidence suggests an immunomodulatory function. Although this drug is a useful tool for several dermatoses, there are associations between its use and neurotoxic and teratogenic side effects. Read More

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Between a rock and a hard place: management of systemic lupus erythematosus and porphyria cutanea tarda.

J Dermatolog Treat 2022 Apr 6:1-3. Epub 2022 Apr 6.

Orlando Dermatology, Graduate Medical Education Consortium, Kansas City University, Orlando, FL, USA.

Porphyria cutanea tarda (PCT), the most common porphyria, is a rare photodermatosis characterized by fragile, hemorrhagic bullae and erosions with associated milia, hyperpigmentation, and hypertrichosis. SLE is a systemic connective tissue disease with approximately 80% of those affected manifesting cutaneous findings. These include malar and discoid rashes, photosensitivity, bullae, oral ulcerations, as well as a variety of other nonspecific findings. Read More

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Assessing the quality of acne and rosacea treatment information on YouTube.

Clin Exp Dermatol 2022 Mar 26. Epub 2022 Mar 26.

Department of Dermatology, Massachusetts General Hospital of Harvard Medical School, Boston, MA, USA.

Cutaneous lupus erythematosus has different manifestation depending on the type. In this study, discoid lupus, extensive skin lesions, fairer skin types and scalp involvement were found to be positive predictive factors for more severe disease. Read More

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Ultraviolet light induces HERV expression to activate RIG-I signalling pathway in keratinocytes.

Exp Dermatol 2022 Mar 24. Epub 2022 Mar 24.

Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China.

Skin inflammation and photosensitivity are common in lupus erythematosus (LE) patients, and ultraviolet (UV) light is a known trigger of skin and possibly systemic inflammation in systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) patients. Type I interferons (IFN) are upregulated in LE skin after UV exposure; however, the mechanisms to explain UVB-induced inflammation remain unclear. Here, we demonstrated that UVB irradiation-induced activation of human endogenous retroviruses (HERVs) plays a major role in the immune response. Read More

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Clinicohistological and immunopathological features of patients with cutaneous lupus erythematosus at tertiary dermatology centre in Malaysia.

Clin Exp Dermatol 2022 Mar 22. Epub 2022 Mar 22.

Department of Dermatology, Hospital Pulau Pinang, Penang, Malaysia.

Background: Cutaneous lupus erythematosus (CLE) is a chronic, autoimmune skin disease with a wide spectrum of clinical presentations in different populations.

Aim: To study the clinicohistological and immunological features of CLE in a multiethnic population and to identify the predictive factors of disease severity based on the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI).

Methods: This was a cross-sectional study of CLE conducted from March 2019 to February 2020. Read More

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Jaccoud-type lupus arthropathy.

Lupus 2022 Apr;31(4):398-406

Serviços Especializados em Reumatologia da Bahia, Salvador, Bahia, Brazil.

Background: Jaccoud's arthropathy (JA) is a condition characterized by joint deformities that have a "reducible" pattern, that is, they return to the normal appearance with a passive manoeuvre. JA was described in patients with rheumatic fever (RF) more than a century ago, and presently, the majority of the patients have systemic lupus erythematosus (SLE).

Purpose: The aim of this review is to draw one attention to the epidemiology, pathogenesis, histopathology, clinical features, imaging, and management of JA in patients with SLE (Jaccoud-type lupus arthropathy). Read More

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