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    Diagnostic value of immunohistochemistry staining of Bcl-2, CD34, CD20 and CD3 for distinction between discoid lupus erythematosus and lichen planus in the skin.
    Indian J Pathol Microbiol 2017 Apr-Jun;60(2):172-176
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    Background: Cluster of differentiation (CD) markers is a classification system for monoclonal antibodies against cell surface molecules on leukocytes and antigens from other cells.

    Aims: The aim of this study is to evaluate immunohistochemical markers in patients with discoid lupus erythematosus (DLE) and lichen planus (LP) and correlation of these markers in two groups and with the normal group in the West of Iran.

    Settings And Design: Analytical cross-sectional study. Read More

    Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome.
    Intern Med 2017 15;56(12):1581-1583. Epub 2017 Jun 15.
    Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan.
    A 35-year-old woman with discoid lupus erythematosus (DLE) was admitted at 11 weeks' gestation with a persistent fever. Laboratory studies revealed pancytopenia, elevated liver enzymes, and hyperferritinemia. Bone marrow aspiration confirmed the diagnosis of hemophagocytic syndrome (HPS). Read More

    Histologic features of chronic cutaneous lupus erythematosus of the scalp using horizontal sectioning: Emphasis on follicular findings.
    J Am Acad Dermatol 2017 Jun 14. Epub 2017 Jun 14.
    Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address:
    Background: Chronic cutaneous lupus erythematosus (CCLE) often affects the scalp resulting in scarring alopecia. While histopathologic findings of CCLE have been well described, there is little written on the morphologic changes to the hair follicles in this condition.

    Objective: We aim to determine the histopathologic findings of hair follicles in CCLE of the scalp. Read More

    Development of classification criteria for discoid lupus erythematosus: Results of a Delphi exercise.
    J Am Acad Dermatol 2017 Jun 9. Epub 2017 Jun 9.
    Harvard Medical School, Boston, Massachusetts; Division of Rheumatology, Departments of Dermatology and Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:
    Background: No classification criteria currently exist for discoid lupus erythematosus (DLE), which has led to problematic heterogeneity in both observational and interventional research efforts.

    Objectives: We sought to develop DLE classification criteria based on consensus of international expert opinion of relevant stakeholders in the field.

    Methods: Using a Delphi consensus process and nominal group techniques, potential items for classification criteria were generated. Read More

    Effect of ethnicity on clinical presentation and risk of antiphospholipid syndrome in Roma and Caucasian patients with systemic lupus erythematosus: a multicenter cross-sectional study.
    Int J Rheum Dis 2017 Jun 7. Epub 2017 Jun 7.
    Department of Internal Medicine, Complejo Hospitalario Universitario de Granada, Granada, Spain.
    Aim: To determine if there are ethnic differences in the prevalence of antiphospholipid syndrome (APS), clinical presentation and autoantibody profile between Roma and Caucasian patients with systemic lupus erythematosus (SLE).

    Method: A cross-sectional study was conducted including data from Roma and Caucasian SLE patients consecutively attending six hospitals in Spain. Socio-demographic characteristics, prevalence of APS, clinical and analytical features of SLE and APS were compared between ethnic groups. Read More

    Intense Pulsed Light and Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment for the Scarring Lesion of Discoid Lupus Erythematosus.
    Ann Dermatol 2017 Jun 11;29(3):331-333. Epub 2017 May 11.
    Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
    Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus that can cause permanent scarring. Treatment of DLE includes protection from sunlight and artificial sources of ultraviolet light, as well as systemic and topical medications. The first-line standard therapies are antimalarials and topical steroids. Read More

    Anti-glomerular basement membrane disease accompanied by systemic lupus erythematosus presenting central nervous system involvement.
    CEN Case Rep 2017 May 27;6(1):1-4. Epub 2016 Aug 27.
    Hokkaido Renal Pathology Center, Sapporo IT Front Building #196 N9 W15, Chuo-ku, Sapporo, Hokkaido, 0600009, Japan.
    We report a case of rapidly progressive glomerulonephritis caused by anti-glomerular basement membrane (GBM) disease accompanied by systemic lupus erythematosus (SLE) presenting central nervous system involvement in a 32-year-old Japanese male. He was admitted to our hospital because of a 3-week history of fever and rapidly failing renal function requiring hemodialysis (HD). Laboratory tests showed anti-GBM antibody elevation with a value of 16,385 units/ml. Read More

    Classifying discoid lupus erythematosus: background, gaps, and difficulties.
    Int J Womens Dermatol 2017 Mar 16;3(1 Suppl):S62-S66. Epub 2017 Feb 16.
    Corporal Michael J. Crescenz VAMC (Philadelphia), Philadelphia, PA.
    To inform our ongoing efforts to develop defining features to be incorporated into a novel set of classification criteria for discoid lupus erythematosus (DLE), we conducted a literature review using the Ovid MEDLINE database. A search was performed to identify studies reporting criteria used to distinguish DLE from other cutaneous lupus erythematosus subtypes. We examined which clinical, histopathologic, and serologic features have data to support their use as effective features in distinguishing DLE from other potential disease mimickers and cutaneous lupus subsets. Read More

    Pathogenesis of cutaneous lupus erythema associated with and without systemic lupus erythema.
    Autoimmun Rev 2017 Jul 5;16(7):735-742. Epub 2017 May 5.
    Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address:
    Cutaneous lupus erythematosus (CLE) can be an individual disease only involving skin, or presents as part of the manifestations of SLE. A small proportion of CLE may progress into SLE, however, the underlying pathogenic mediators remain elusive. By only including researches that clearly described if the subtypes of CLE presented by enrolled subjects was associated with or without SLE, we provided an overview of antibodies, inflammatory cells and inflammatory molecular mediators identified in blood and skin that were possibly involved in lupus skin damages. Read More

    Clinical and immunological characteristics of 150 systemic lupus erythematosus patients in Jamaica: a comparative analysis.
    Lupus 2017 Jan 1:961203317707828. Epub 2017 Jan 1.
    1 Department of Medicine, University of the West Indies, Mona, Jamaica.
    Background Epidemiological studies in systemic lupus erythematosus have been reported in the literature in many countries and ethnic groups. Although systemic lupus erythematosus in Jamaica has been described in the past, there has not been a detailed evaluation of systemic lupus erythematosus patients in urban Jamaica, a largely Afro-Caribbean population. The goal of this study was to describe the clinical features, particularly disease activity, damage index and immunological features, of 150 systemic lupus erythematosus subjects. Read More

    Ultraviolet-A1 irradiation therapy for systemic lupus erythematosus.
    Lupus 2017 Jan 1:961203317707064. Epub 2017 Jan 1.
    Veterans Administration, New Orleans, LA, USA.
    Systemic lupus erythematosus (lupus, SLE) is a chronic autoimmune disease characterized by the production of autoantibodies, which bind to antigens and are deposited within tissues to fix complement, resulting in widespread systemic inflammation. The studies presented herein are consistent with hyperpolarized, adenosine triphosphate (ATP)-deficient mitochondria being central to the disease process. These hyperpolarized mitochondria resist the depolarization required for activation-induced apoptosis. Read More

    Drugs for discoid lupus erythematosus.
    Cochrane Database Syst Rev 2017 May 5;5:CD002954. Epub 2017 May 5.
    Department of Dermatology, Broadgreen Hospital, Liverpool, UK, L14 3LB.
    Background: Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus, which can cause scarring. Many drugs have been used to treat this disease and some (such as thalidomide, cyclophosphamide and azathioprine) are potentially toxic. This is an update of a Cochrane Review first published in 2000, and previously updated in 2009. Read More

    Oral manifestations of lupus.
    Ir J Med Sci 2017 May 3. Epub 2017 May 3.
    Department of Dermatology, St. James's Hospital, Dublin, 8, Ireland.
    Introduction: Mucosal involvement is commonly seen in patients with lupus; however, oral examination is often forgotten. Squamous cell carcinoma arising within oral lupoid plaques has been described, emphasizing the importance of identifying and treating oral lupus.

    Methods: We undertook a retrospective single-centre study looking at oral findings in patients attending our multidisciplinary lupus clinic between January 2015 and April 2016. Read More

    Development of new extra-glandular manifestations or associated auto-immune diseases after establishing the diagnosis of primary Sjögren's syndrome : A long-term study of the Antonius Nieuwegein Sjögren (ANS) cohort.
    Rheumatol Int 2017 Apr 19. Epub 2017 Apr 19.
    Department of Clinical Epidemiology and Medical Statistics, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.
    To investigate in a long-term study, the development of new extra-glandular manifestations (EGM) or associated auto-immune diseases (AID) from 1 year after establishing the diagnosis of primary Sjögren's syndrome (pSS). The primary goal was to examine the frequency and type of these manifestations and to find out which demographic, clinical and serological profile was most at risk. All outpatients diagnosed with primary Sjögren's syndrome were included in a retrospective study, with at least one check-up per year, from June 1991 until August 2015. Read More

    Discoid Lupus and Human Immunodeficiency Virus: A Retrospective Chart Review to Determine the Prevalence and Progression of Co-occurrence of these Conditions at a Single Academic Center.
    Indian J Dermatol 2017 Mar-Apr;62(2):226
    Department of Dermatology, University of California, San Diego, CA, USA.
    Context: Discoid lupus erythematosus (DLE) and human immunodeficiency virus (HIV) are both disorders of the immune system. The pathophysiology of these diseases varies greatly as DLE is characterized by an overactive immune system that attacks normal host cells, whereas HIV is characterized by an exogenous attack on the immune system that depletes it of key cell types. Although the reason is unknown, co-occurrence of DLE and HIV is rare. Read More

    [How I explore… scalp and hairin erythemato-squamous disorders].
    Rev Med Liege 2016 Oct;71(10):460-462
    Service de Dermatopathologie, CHU de Liège, Belgique.
    In their early stages, some dermatoses of the scalp such as psoriasis seborrheic dermatitis, tinea capitis and discoid lupus erythematosus are often hardly noticeable to others. However, the eruptions are occasionally severe and extensive. Reaching an adequate diagnosis is of utmost impor¬tance for an adequate healthcare. Read More

    Predictors of low quality of life in discoid lupus patients.
    Br J Dermatol 2017 Mar 24. Epub 2017 Mar 24.
    University of Texas Southwestern Medical Center, Department of Dermatology, Dallas, TX.
    Discoid lupus erythematosus (DLE) is unique from other cutaneous lupus erythematosus (CLE) subtypes because of dyspigmentation and scarring, which are associated with quality of life (QoL) impairment in other skin disorders.(1, 2) While previous QoL studies have included heterogeneous cohorts of patients with CLE, we focused on patients with DLE to identify clinical and demographic features that correlate with QoL impairment. We hypothesized that greater skin disease activity, skin disease damage, dark skin type, female gender, low socioeconomic status (defined by annual income), and current smoking status would be associated with poorer QoL in patients with DLE. Read More

    Successful treatment of recalcitrant discoid lupus erythematosus with ustekinumab.
    Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.
    Department of Dermatology, Hospital Universitario de Fuenlabrada, Madrid.
    We report a 52-year old woman with a 28-year historyof disfiguring facial discoid lupus erythematosus(DLE), persistent despite both classical therapiesand rituximab. Ustekinumab 45 mg was started incombination with methotrexate and intralesionalcorticosteroids. Methotrexate and intralesionalcorticosteroids were withdrawn 30 months later andustekinumab maintained as monotherapy. Read More

    Immunopathogenic Oral Diseases: An Overview 
Focusing on Pemphigus Vulgaris and Mucous Membrane Pemphigoid.
    Oral Health Prev Dent 2017;15(2):177-182
    Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Read More

    Periorbital discoid lupus: a rare localization in a patient with systemic lupus erythematosus.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):122-124
    Istanbul Medeniyet University School of Medicine - Istanbul, Turkey.
    A 40-year-old female patient with a 5-year history of systemic lupus erythematosus was referred to our policlinic with complaints of erythema, atrophy, and telangiectasia on the upper eyelids for 8 months. No associated mucocutaneous lesion was present. Biopsy taken by our ophthalmology department revealed discoid lupus erythematosus. Read More

    Frontal fibrosing alopecia in association with Sjögren's syndrome: more than a simple coincidence.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):14-16
    Hospital do Servidor Público Estadual do Estado de São Paulo (HSPE) - São Paulo (SP), Brazil.
    Frontal fibrosing alopecia is a distinctive form of scarring alopecia considered to be a clinical variant of lichen planopilaris. It predominantly occurs in postmenopausal women and has a slowly progressive course. It was first described by Kossard in 1994. Read More

    [Rare cutaneous tuberculosis in sub-Saharan Africa developed on discoid lupus erythematous lesion].
    Bull Soc Pathol Exot 2017 Feb 28. Epub 2017 Feb 28.
    Dermatologie, hôpital institut d'hygiène sociale de Dakar, université Cheikh-Anta-Diop de Dakar, BP 7045, Dakar, Sénégal.
    Lupus vulgaris is a common presentation of cutaneous tuberculosis (TB), but its ulcerative or vegetating form also called vorax is rare.We report a case of lupus vulgaris in its vorax form, which occurred in a patient with discoid lupus erythematous. A 42-year-old patient monitored for chronic lupus erythematosus consulted again for a facial tumor and fever. Read More

    Frontal Fibrosing Alopecia Coexisting with Lupus Erythematosus: Poor Response to Hydroxychloroquine.
    Skin Appendage Disord 2017 Jan 12;2(3-4):162-165. Epub 2016 Nov 12.
    Dermatology Clinic, Hospital do Servidor Público Municipal de São Paulo, São Paulo, Brazil.
    Lupus erythematosus, especially the discoid form, and lichen planopilaris may be associated and can occur in different topographies (coexistence) or in the same lesion (lupus eythematosus/lichen planus overlap syndrome). Frontal fibrosing alopecia is considered a variant form of lichen planopilaris and is characterized by frontotemporal hairline and eyebrow involvement. Of the association with lupus erythematosus we have only a few descriptions. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Association study between the TP53 Rs1042522G/C polymorphism and susceptibility to systemic lupus erythematosus in a Chinese Han population.
    Rheumatol Int 2017 Apr 9;37(4):523-529. Epub 2017 Feb 9.
    Department of Information, The Second Hospital of Anhui Medical University, 678 Furong Road Hefei, Anhui, 230601, China.
    Tumour suppressor protein 53 (p53) plays a central role in apoptosis, cell proliferation and death. Previously studies found contribution of functional p53 Arg72Pro polymorphism (TP53 rs1042522G/C polymorphism) in the development of systemic lupus erythematosus (SLE) remains controversial. In this study, for the first time, we evaluated its association with SLE in a Chinese Han population. Read More

    A retrospective study comparing histopathological and immunopathological features of nasal planum dermatitis in 20 dogs with discoid lupus erythematosus or leishmaniosis.
    Vet Dermatol 2017 Apr 29;28(2):200-e46. Epub 2017 Jan 29.
    Veterinaria Cetego, Via M.C. Cetego 20, 00177, Roma, Italy.
    Background: In areas endemic for leishmaniosis, discoid lupus erythematosus (DLE) and canine leishmaniosis (CanL) are the most common differential diagnoses for nasal planum erosive-ulcerative dermatitis in dogs.

    Hypothesis/objective: To compare histopathological and immunopathological features of canine nasal planum erosive-ulcerative dermatitis with depigmentation due to DLE or CanL.

    Animals: Nasal planum biopsies from dogs with nasal planum loss of architecture, depigmentation, swelling, erosions or ulcerations due to DLE (n = 14) or CanL (n = 6). Read More

    High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study.
    J Immunol Res 2017 3;2017:3972706. Epub 2017 Jan 3.
    Department of Dermatology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
    Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control group. Additionally, we intended to determine the differences of sociodemographic and clinical data of the DLE patients with MetS compared to the patients without MetS. Read More

    Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti-Interferon-γ Antibody, in Patients With Discoid Lupus Erythematosus.
    Arthritis Rheumatol 2017 May 31;69(5):1028-1034. Epub 2017 Mar 31.
    Amgen Inc., Thousand Oaks, California.
    Objective: Interferon-γ (IFNγ) is implicated in the pathogenesis of discoid lupus erythematosus (DLE). This study sought to evaluate a single dose of AMG 811, an anti-IFNγ antibody, in patients with DLE.

    Methods: The study was designed as a phase I randomized, double-blind, placebo-controlled crossover study of the pharmacodynamics, safety, and clinical efficacy of AMG 811 in patients with DLE. Read More

    ANA-Negative Presentation of SLE in Man with Severe Autoimmune Neutropenia.
    Case Rep Med 2016 19;2016:6853936. Epub 2016 Dec 19.
    University of California San Diego School of Medicine, La Jolla, CA, USA.
    Background. Systemic lupus erythematosus (SLE) is a chronic, inflammatory, connective tissue disease that commonly affects the joints and a variety of organs due to an overactivation of the body's immune system. There is wide heterogeneity in presentation of SLE patients, including lung, central nervous system, skin, kidney, and hematologic manifestations. Read More

    Oral lichenoid lesions: distinguishing the benign from the deadly.
    Mod Pathol 2017 Jan;30(s1):S54-S67
    Professor Emeritus, Emory University School of Medicine: Atlanta Oral Pathology, Decatur, GA, USA.
    Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus. Read More

    Autoimmune collagen vascular diseases: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):678-689. Epub 2016 Jul 9.
    Assistant Professor of Dermatology, University of Connecticut School of Medicine, Farmington, CT.
    Morphea, dermatomyositis (DM), and discoid lupus erythematosus (DLE) are autoimmune collagen vascular diseases that can present at any age. In all three of these diseases, the tenants of diagnosis and treatment are largely the same in both children and adults, with a few notable differences. Children with morphea are more likely to present with the linear subtype and have a higher incidence of extracutaneous manifestations. Read More

    The Relationship Between Disease Severity in Discoid Lupus Erythematosus and Quality of Life.
    Br J Dermatol 2016 Dec 10. Epub 2016 Dec 10.
    Department of Dermatology, Counties Manukau District Health Board, Private Bag, 93311, Auckland, New Zealand.
    Discoid Lupus Erythematosus (DLE) is a chronic scarring skin condition and a subset of cutaneous lupus as defined by Gilliam and Sontheimer (1). It is a common form of cutaneous lupus in a European population (CLE) (2). The objective of this study was to assess the effect of DLE severity on quality of life (QOL). Read More

    Primary cicatricial alopecia: Lymphocytic primary cicatricial alopecias, including chronic cutaneous lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia, and Graham-Little syndrome.
    J Am Acad Dermatol 2016 Dec;75(6):1081-1099
    Department of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada; Department of Dermatology, New York University, New York, New York.
    Both primary and secondary forms of cicatricial alopecia have been described. The hair follicles are the specific target of inflammation in primary cicatricial alopecias. Hair follicles are destroyed randomly with surrounding structures in secondary cicatricial alopecia. Read More

    Comparison of ethnicity, gender, age of onset and outcome in South Africans with systemic lupus erythematosus.
    Lupus 2017 Apr 12;26(4):438-446. Epub 2016 Nov 12.
    3 Department of Nephrology, Inkosi Albert Luthuli Central Hospital, and School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.
    Ethnicity, gender and age of onset are reported to influence the expression and outcome of systemic lupus erythematosus. We studied a multi-ethnic cohort of 408 South Africans (91.2% females) comprising 237 (58. Read More

    Lenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus.
    Lupus 2017 May 12;26(6):646-649. Epub 2016 Nov 12.
    2 Department of Pediatrics, Duke University Medical Center, Durham, USA.
    Objective Cutaneous manifestations of pediatric systemic lupus erythematosus cause significant morbidity. Lenalidomide, a thalidomide analogue, has shown promise treating cutaneous lupus erythematosus in adults. Our objective was to evaluate lenalidomide's efficacy and safety in treating refractory cutaneous manifestations of pediatric systemic lupus erythematosus. Read More

    Frequency and predictors of the lupus low disease activity state in a multi-national and multi-ethnic cohort.
    Arthritis Res Ther 2016 Nov 9;18(1):260. Epub 2016 Nov 9.
    The University of Melbourne, Melbourne, Australia.
    Background: Systemic lupus erythematosus (SLE) is a chronic heterogeneous disease with considerable burden from disease activity and damage. A novel clinical treatment target in the form of the lupus low disease activity state (LLDAS) has been recently reported, with retrospective validation showing that time spent in LLDAS translates to reduced damage accrual. The objectives of this study were to describe the frequency and identify the predictors of attaining LLDAS in a large multinational cohort of patients with SLE. Read More

    Update on Lupus Nephritis.
    Clin J Am Soc Nephrol 2017 May 7;12(5):825-835. Epub 2016 Nov 7.
    Department of Internal Medicine, The Ohio State Wexner Medical Center, Columbus, Ohio
    SLE is a chronic inflammatory disease that affects the kidneys in about 50% of patients. Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite potent anti-inflammatory and immunosuppressive therapies still ends in CKD or ESRD for too many patients. This review highlights recent updates in our understanding of disease epidemiology, genetics, pathogenesis, and treatment in an effort to establish a framework for lupus nephritis management that is patient-specific and oriented toward maintaining long-term kidney function in patients with lupus. Read More

    Features of 847 Childhood-Onset Systemic Lupus Erythematosus Patients in Three Age Groups at Diagnosis: A Brazilian Multicenter Study.
    Arthritis Care Res (Hoboken) 2016 Nov 6;68(11):1736-1741. Epub 2016 Oct 6.
    Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
    Objective: To evaluate demographic data and clinical and laboratory features at disease diagnosis in 3 different age groups of childhood-onset systemic lupus erythematosus (SLE): group A, early-onset (<6 years); group B, school age (≥6 to <12 years); and group C, adolescent (≥12 to <18 years).

    Methods: This was a Brazilian multicenter cohort retrospective study in 10 pediatric rheumatology centers, including 847 childhood-onset SLE patients.

    Results: Patients were divided into 3 groups: group A with 39 patients (4%), group B with 395 patients (47%), and group C with 413 patients (49%). Read More

    Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases).
    Vet Dermatol 2016 Dec 16;27(6):488-e131. Epub 2016 Oct 16.
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
    Background: Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized.

    Hypothesis/objectives: We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE.

    Methods: Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis). Read More

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