3,659 results match your criteria Lupus Erythematosus Discoid


[Systemic Lupus Erythematosus].

Authors:
Tetsuya Tsuchida

Brain Nerve 2019 Apr;71(4):317-321

Department of Dermatology, Saitama Medical University.

The cutaneous manifestations of lupus erythematosus (LE) include LE-specific and LE-nonspecific skin lesions. LE-specific skin lesions are divided into chronic, subacute, and acute types. The representatives of the chronic and acute types are discoid lupus erythematosus (DLE) and butterfly rash, respectively. Read More

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http://dx.doi.org/10.11477/mf.1416201268DOI Listing
April 2019
1 Read

Systemic lupus erythematosus camouflaging: As refractory acne in a young girl.

J Family Med Prim Care 2019 Jan;8(1):276-279

Department of Dermatology, Tata Main Hospital, Jamshedpur, Jharkhand, India.

Cutaneous manifestations of systemic lupus erythematosus (SLE) are important diagnostic criteria as described by the revised American College of Rheumatology and Systemic Lupus International Collaborating Clinics. Patients usually present with various lupus-specific cutaneous manifestations such as malar rash, discoid rash, photosensitivity, and alopecia. Acneiform presentation of SLE is extremely rare. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_376_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396584PMC
January 2019
1 Read

'"Perforation of paper with pen: Simple technique to explain 'Carpet Tack sign" in Discoid Lupus Erythematosus (DLE)".

Authors:
Arun C Inamadar

J Am Acad Dermatol 2019 Mar 21. Epub 2019 Mar 21.

Professor and Head, Dept. of Dermatology, Venereology & Leprosy, Sri B.M. Patil Medical College, Hospital & Research Center, BLDE Deemed University, Vijayapur, Karnataka, India. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.03.039DOI Listing

Inflammatory chemokine profiles and their correlations with effector CD4 T cell and regulatory cell subpopulations in cutaneous lupus erythematosus.

Cytokine 2019 Mar 20;119:95-112. Epub 2019 Mar 20.

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Vasco de Quiroga No. 15, Colonia Belisario Domínguez Sección XVI, 14080 Mexico City, Mexico. Electronic address:

We compared the chemokine/receptor expression in skin biopsies of discoid (SLE/DLE) and subacute lupus (SLE/SCLE) and correlated it with tissue and circulating effector CD4 T cells/regulatory cells. Skin biopsies and peripheral blood from 9 active SLE/DLE patients, 9 SLE/SCLE patients, 5 control SLE patients without cutaneous lesions and 10 control healthy donors were included. Clinical skin activity was measured by Cutaneous Lupus Erythematosus Disease Area and Severity Index scoring, and systemic activity was measured by a modified SLEDAI-2K excluding the cutaneous items. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.010DOI Listing
March 2019
1 Read

Bullous systemic lupus erythematosus - a case report.

Autops Case Rep 2019 Jan-Mar;9(1):e2018069. Epub 2019 Feb 25.

Universidade de São Paulo, Hospital Universitário, Department of Internal Medcine. São Paulo, SP, Brazil.

Skin involvement in systemic lupus erythematosus (SLE) occurs in more than 75% of patients with this condition. Vesicles and blisters in lupus erythematosus (LE) may be present in SLE secondary to interface vacuolar changes in the epidermis, in discoid LE also secondary to vacuolar epidermal changes, and in bullous LE secondary to antibodies anti-collagen VII deposits with neutrophilic aggregates. In addition, blisters can occur due to the association of SLE with other autoimmune blistering diseases (e. Read More

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http://www.autopsyandcasereports.org/article/doi/10.4322/acr
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http://dx.doi.org/10.4322/acr.2018.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394362PMC
February 2019
4 Reads

Glycoprotein 96 polymorphisms are associated with the risk of systemic lupus erythematosus: A case-control study.

Int J Rheum Dis 2019 Mar 12. Epub 2019 Mar 12.

Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Aim: To investigate the clinical implications of a genetic polymorphism in glycoprotein 96 (GP96), by analyzing the association between the genotype and haplotype of GP96 with systemic lupus erythematosus (SLE).

Method: We analyzed cell-surface expression of GP96 in peripheral blood mononuclear cells (PBMCs) and serum titer of anti-GP96 antibody of SLE patients. Single nucleotide polymorphisms and deletion mutants of GP96 were detected by two-dimensional gene scanning (TDGS). Read More

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http://dx.doi.org/10.1111/1756-185X.13515DOI Listing
March 2019
2 Reads

Tubular Hair Casts in Trichoscopy of Hair and Scalp Disorders.

Int J Trichology 2019 Jan-Feb;11(1):14-19

Department of Dermatology, College of Medical Sciences, Bharatpur, Nepal.

Introduction: Hair casts have been reported in a variety of hair and scalp disorders. Trichoscopy allows a quick and noninvasive method for the evaluation of hair and scalp disorders in high magnification. However, the study of hair casts seen in trichoscopy is lacking. Read More

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http://dx.doi.org/10.4103/ijt.ijt_77_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385511PMC
March 2019
12 Reads

Novel biomarkers containing citrullinated peptides for diagnosis of systemic lupus erythematosus using protein microarrays.

Clin Exp Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Microbiology, Wu Lien-Teh Institute, Harbin Medical University, Harbin, China.

Objectives: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterised by autoantibody production. This study aims to identify biomarkers involving citrullinated peptides that can be used for SLE diagnosis.

Methods: After a negative selection step with serum from healthy controls (HCs), a phage library of 12 peptides was used for three rounds of screening with sera from 30 SLE patients. Read More

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February 2019
1 Read
2.724 Impact Factor

Practice-Based Differences in Pediatric Discoid Lupus Erythematosus.

Br J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Northwestern University Feinberg School of Medicine, Department of Dermatology and Pediatrics, Chicago, Illinois, United States.

Background: Children with discoid lupus erythematosus (DLE) are at risk for disfigurement and progression to systemic lupus erythematosus (SLE). Consensus is lacking regarding optimal care of children with DLE.

Objectives: We compared practice patterns among pediatric dermatologists/rheumatologists treating pediatric DLE. Read More

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http://dx.doi.org/10.1111/bjd.17780DOI Listing
February 2019
1 Read

Cutaneous lupus associated with pembrolizumab therapy for advanced melanoma: a report of three cases.

Melanoma Res 2019 Feb 11. Epub 2019 Feb 11.

Departments of Dermatology.

Checkpoint blockade immunotherapy has revolutionized the treatment of advanced melanoma, with impressive survival benefits attained through upregulation of the anticancer immune response. Blockade of regulatory checkpoint molecules can, however, also result in aberrant immune activation leading to undesirable inflammation and autoimmunity. Although many genetic determinants have been described in patients with primary autoimmune diseases, it is uncertain whether patients developing autoimmune skin disease as an adverse effect of anti-PD-1 therapy share the same genetic risks. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000587DOI Listing
February 2019
1 Read

A Study of the Histopathological Features of Alopecias on Transverse Sections of Scalp Biopsies.

Indian J Dermatol 2019 Jan-Feb;64(1):47-54

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Transverse sections of scalp biopsies are performed for the assessment of alopecias and are considered advantageous over vertical sections.

Aim: The aim was to study the histopathological features of alopecias on transverse sections of scalp biopsies.

Methods: It was a descriptive study. Read More

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http://dx.doi.org/10.4103/ijd.IJD_477_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340243PMC
February 2019
3 Reads

Intravenous immunoglobulin G use in patients with chronic inflammatory demyelinating polyneuropathy: An uncommon cause of drug-induced discoid lupus erythematosus.

Australas J Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Dermatology, Temple University Hospital, Philadelphia, Pennsylvania, USA.

Drug-induced chronic cutaneous lupus erythematosus, or drug-induced discoid lupus erythematosus, is a rare cutaneous phenomenon. Various medications have been associated with drug-induced discoid lupus erythematosus including fluorouracile agents, especially tegafur and uraciltegafur, and TNF-α antagonists such as infliximab or etanercept. Recent literature has described a case series of six patients receiving IgG immunoglobulin for chronic inflammatory demyelinating polyneuropathy with subsequent presentations of discoid lupus erythematosus. Read More

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http://dx.doi.org/10.1111/ajd.12998DOI Listing
February 2019
3 Reads

Increased level of B cell differentiation factor in systemic lupus erythematosus patients.

J Genet Eng Biotechnol 2018 Dec 30;16(2):467-471. Epub 2018 May 30.

Medical physiology Department Medical Division National Research Center, 33 El-Bohouth Street, Dokki, POB:12311, Cairo, Egypt.

Most autoimmune disease are driven by a dysfunction in T and B cells, but B cells are still an interesting area of research, perturbations in their development are implicated in autoimmune diseases. B cell differentiating factor (BCDF) plays a part in the differentiation of B cells. The aim was To assess the levels of BCDF, IgM and IgG in SLE patients and whether they have any peculiarity in the clinical context of SLE. Read More

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http://dx.doi.org/10.1016/j.jgeb.2018.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353854PMC
December 2018
1 Read

Direct immunofluorescence findings in cicatricial alopecia: A retrospective study of 155 cases.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):103-106

Department of Dermatology, Maulana Azad Medical College, New Delhi, India.

Objectives: To study the direct immunofluorescence (DIF) in cicatricial alopecia (CA) patients.

Materials And Methods: Approximately, 155 skin biopsies from CA patients examined over 7 years (2009-2015). Special stains and Hematoxylin and Eosin were performed, and final histopathological diagnosis was made. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_428_18DOI Listing
February 2019
2 Reads

Validation and reliability of a disease-specific quality-of-life measure in patients with cutaneous lupus erythematosus.

Br J Dermatol 2019 Jan 13. Epub 2019 Jan 13.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, U.S.A.

Background: Cutaneous lupus erythematosus (CLE) is a potentially disfiguring, chronic autoimmune disease with variable skin manifestations, negatively affecting patients' quality of life (QoL). Patient-reported outcome (PRO) measures assessing QoL in patients with CLE have been generic or developed without input from patients.

Objectives: To demonstrate the reliability and validity of a disease-specific QoL measure for CLE - the cutaneous lupus erythematosus quality of life (CLEQoL). Read More

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http://doi.wiley.com/10.1111/bjd.17636
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http://dx.doi.org/10.1111/bjd.17636DOI Listing
January 2019
8 Reads

Serum Transforming Growth Factor-Beta 1 Level in Egyptian Systemic Lupus Erythematosus Patients.

Arch Rheumatol 2018 Sep 31;33(3):358-366. Epub 2018 Jul 31.

Department of Internal Medicine, Cairo University, Cairo, Egypt.

Objectives: This study aims to assess the role of transforming growth factor-beta 1 (TGF-β1) in systemic lupus erythematosus (SLE).

Patients And Methods: The study included 40 female SLE patients (mean age 25.5±6. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2018.6405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328217PMC
September 2018
1 Read

Immunological methods for the diagnosis of oral mucosal diseases.

Br J Dermatol 2018 Dec 26. Epub 2018 Dec 26.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.

Immunological methods, which have been widely used in autoimmune blistering diseases (AIBDs) of the oral mucosa, can also be adopted as auxiliary diagnostic tools in oral lichen planus (OLP) and discoid lupus erythematosus (DLE). AIBDs, characterized by autoantibodies against structural proteins of keratinocytes or the basement membrane zone, clinically present as blisters and erosions of the oral mucosa. When atypical lesions occur, OLP or DLE may be confused with AIBDs. Read More

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http://dx.doi.org/10.1111/bjd.17589DOI Listing
December 2018

[Chloroquine retinopathy].

Ned Tijdschr Geneeskd 2018 Dec 17;163. Epub 2018 Dec 17.

LUMC, afd. Dermatologie, Leiden.

Background: Chloroquine (CQ) and hydroxychloroquine (HCQ) can induce retinopathy. The risk of this severe, irreversible ophthalmological complication significantly increases with duration of treatment (> 5 years) and dosage of medication (for CQ > 2.3 mg/kg/day and HCQ > 5. Read More

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December 2018
12 Reads

REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A).

Ann Rheum Dis 2019 Feb 18;78(2):238-248. Epub 2018 Dec 18.

Laboratory of Immune Regulation and Tolerance, Autoimmunity and Inflammation, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

Objectives: The release of neutrophil extracellular traps (NETs) represents a novel neutrophil effector function in systemic lupus erythematosus (SLE) pathogenesis. However, the molecular mechanism underlying NET release and how NETs mediate end-organ injury in SLE remain elusive.

Methods: NET formation and NET-related proteins were assessed in the peripheral blood and biopsies from discoid lupus and proliferative nephritis, using immunofluorescence, immunoblotting, quantitative PCR and ELISA. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-213181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352428PMC
February 2019
6 Reads

Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia.

Am J Dermatopathol 2019 May;41(5):350-354

Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Background: Premature desquamation of the inner root sheath (PDIRS) is considered one of the distinctive features in central centrifugal cicatricial alopecia (CCCA). However, PDIRS can be seen in other alopecia subtypes, and its utility in the diagnosis of CCCA has been debated. We aimed to examine a large cohort of alopecia cases for the presence of PDIRS in association with and without inflammation to determine whether PDIRS in noninflamed follicles can be used as a specific marker of CCCA. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001336DOI Listing
May 2019
3 Reads

Detection of DNA Autoantibodies by Electrophoretic Mobility Shift Assay.

Methods Mol Biol 2019 ;1901:133-152

Laboratory for Life Sciences, Tehran, Iran.

Although the presence of antibodies against double-stranded (ds) DNA is considered the serological hallmark of systemic lupus erythematosus (SLE), it is not detected in all SLE patients by routine laboratory tests. Looking at DNA-anti(ds)DNA interaction as one kind of DNA-protein interaction gave us the grounds for a novel type of assay, easy to perform, and providing a direct insight on DNA-anti(ds)DNA IgG interaction. The assay is an application of the electrophoretic mobility shift assay (EMSA) and is based on the observation that the electrophoretic mobility of a DNA-protein complex is typically less than that of free DNA. Read More

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http://link.springer.com/10.1007/978-1-4939-8949-2_11
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http://dx.doi.org/10.1007/978-1-4939-8949-2_11DOI Listing
January 2019
10 Reads

Persistent red and swollen eyelids.

Lancet 2018 10;392(10157):1552

Department of Dermatology, Chitose City Hospital, Chitose, Japan. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)32327-4DOI Listing
October 2018
6 Reads

Systemic Lupus Erythematous: Symptoms and Signs at Initial Presentations.

Antiinflamm Antiallergy Agents Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Rheumatology Department, Ministry of Health and Prevention, PO Box 65522, Dubai. Saudi Arabia.

Systemic lupus erythematosus (SLE) is an autoimmune multisystem inflammatory condition that causes microvascular inflammation with the production of various auto-antibodies that play a major role in its pathogenesis. SLE can affect both sexes, all ages, and all ethnic groups with widespread geographical and socioeconomic backgrounds. Asia encompasses people of many sociocultural backgrounds with diverse ethnic. Read More

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http://dx.doi.org/10.2174/1871523018666181128161828DOI Listing
November 2018
38 Reads

Koebner phenomenon of discoid lupus erythematosus on old tattoos.

Lupus 2019 Feb 28;28(2):241-243. Epub 2018 Nov 28.

1 Division of Dermatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

The Koebner phenomenon is the development of lesions in traumatized skin, often with spontaneously occurring lesions elsewhere. We report a case of a woman in her 20 s presenting with discoid lesions superimposed on tattoos that she obtained many years ago. Although a few case reports have been published describing development of lesions on red tattoos attributed to photosensitivity, or koebnerization occurring less than a month following tattoo placement, our patient demonstrates a unique delayed development of discoid lesions years after obtaining her tattoos in non-sun exposed skin. Read More

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http://dx.doi.org/10.1177/0961203318815578DOI Listing
February 2019

Frontal Fibrosing Alopecia and Discoid Lupus Erythematosus: More Than a Coincidence.

Actas Dermosifiliogr 2018 Oct 25. Epub 2018 Oct 25.

Unidad de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Campus de la Salud de Granada, Granada, España. Electronic address:

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http://dx.doi.org/10.1016/j.ad.2018.02.033DOI Listing
October 2018
1 Read

[Connective tissue diseases in the hospital setting in Lomé: a retrospective study of 231 cases].

Pan Afr Med J 2018 26;30:176. Epub 2018 Jun 26.

Service de Dermatologie-Vénérologie, Faculté des Sciences de Santé Lomé, Lomé, Togo.

This study aimed to highlight the epidemiological , clinical, therapeutic and evolutionary profile of connective tissue diseases in the hospitals setting in Lomé. We conducted a retrospective and descriptive study from January 1, 1993 to December 30, 2012. We focused on the medical records of patients with connective tissue diseases hospitalized in five Departments of Dermatology and Rheumatology at the Hospitals in Lomé. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.176.14565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235477PMC
December 2018
3 Reads

Lichen Planus Pigmentosus and Frontal Fibrosing Alopecia Mimicking Discoid Lupus Erythematosus.

Arthritis Rheumatol 2019 Mar 1;71(3):478. Epub 2019 Feb 1.

Corporal Michael J. Crescenz VAMC and University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1002/art.40779DOI Listing
March 2019
2 Reads

Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden.

Psychiatr Genet 2019 04;29(2):37-43

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Aims: In the era of genome-wide association studies, familial risks are used to estimate disease heritability and success in gene identification. We wanted to estimate associations of 42 autoimmune diseases with attention-deficit hyperactivity disorder (ADHD) between individuals and family members.

Participants And Methods: The availability of a Multigeneration Register in Sweden provides reliable access to family data that covers the last century. Read More

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http://dx.doi.org/10.1097/YPG.0000000000000212DOI Listing
April 2019
6 Reads

Alopecias in lupus erythematosus.

Lupus Sci Med 2018 25;5(1):e000291. Epub 2018 Oct 25.

Corporal Michael J Crescenz VAMC, Philadelphia, Pennsylvania, USA.

Several patterns of hair loss can occur in lupus erythematosus (LE). Alopecias which show histological characteristics of LE are LE-specific, and include discoid LE (DLE), diffuse or patchy hair loss in acute LE, subacute cutaneous LE, and rarely tumid LE. Lupus hair in SLE is a poorly characterised entity and may be a form of telogen effluvium. Read More

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http://dx.doi.org/10.1136/lupus-2018-000291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203010PMC
October 2018
5 Reads

A comparative immunohistochemical study of epidermal and dermal/perifollicular Langerhans cell concentration in discoid lupus erythematosus and lichen planopilaris: a cross-sectional study.

Lupus 2018 Dec 30;27(14):2200-2205. Epub 2018 Oct 30.

1 Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: There are times when differentiation between discoid lupus erythematosus (DLE) and lichen planopilaris (LPP) becomes quite challenging clinicopathologically.

Objectives: The aim of this study was to evaluate and compare the concentration, distribution pattern and role of Langerhans cells (LCs), identified by CD1a staining in DLE and LPP.

Methods: Twenty-five specimens of skin biopsies from patients diagnosed with LPP and DLE were included. Read More

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http://dx.doi.org/10.1177/0961203318808587DOI Listing
December 2018

Skin signs in juvenile- and adult-onset systemic lupus erythematosus: clues to different systemic involvement.

Lupus 2018 Nov 18;27(13):2069-2075. Epub 2018 Oct 18.

1 Division of Dermatology, Chulalongkorn University, Bangkok, Thailand.

Objective: We aim to explore the differences of skin signs between juvenile- and adult-onset systemic lupus erythematosus and to identify their associations to the development of systemic involvement.

Methods: A retrospective chart review of 377 systemic lupus erythematosus patients was performed.

Results: In total, 171 patients with juvenile systemic lupus erythematosus and 206 with adult systemic lupus erythematosus were studied. Read More

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http://dx.doi.org/10.1177/0961203318805851DOI Listing
November 2018
4 Reads
2.200 Impact Factor

Chronic cutaneous lupus erythematosus and topical clindamycin.

BMJ Case Rep 2018 Sep 23;2018. Epub 2018 Sep 23.

Dermatology Residency, Affiliated Dermatology, Scottsdale, Arizona, USA.

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http://dx.doi.org/10.1136/bcr-2018-226728DOI Listing
September 2018

[34-Year-Old Patient with Scarred-Scaly Skin Changes].

Authors:
Dieter Krahl

Dtsch Med Wochenschr 2018 09 19;143(19):1361-1362. Epub 2018 Sep 19.

HEIDELBERGHISTO, Heidelberg.

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http://dx.doi.org/10.1055/a-0681-8749DOI Listing
September 2018
1 Read

Canine Cutaneous Lupus Erythematosus: Newly Discovered Variants.

Authors:
Frane Banovic

Vet Clin North Am Small Anim Pract 2019 Jan 15;49(1):37-45. Epub 2018 Sep 15.

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Athens, GA 30605, USA. Electronic address:

As the spectrum of canine cutaneous lupus erythematosus (CLE) variants has expanded markedly in the recent 2 decades, veterinarians are encouraged to become familiar with the characteristic clinical features of CLE variants to permit early diagnosis and appropriate treatment. This article describes the signalment, clinical signs, treatment outcome, and laboratory and histopathology findings of 2 new canine CLE variants, generalized discoid lupus erythematosus and mucocutaneous lupus erythematosus. Read More

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http://dx.doi.org/10.1016/j.cvsm.2018.08.004DOI Listing
January 2019
9 Reads

Usefulness of Pulsed Dye Laser in Cutaneous Lupus Erythematosus.

Actas Dermosifiliogr 2018 Sep 10. Epub 2018 Sep 10.

Departamento de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.

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http://dx.doi.org/10.1016/j.ad.2018.03.020DOI Listing
September 2018
2 Reads

Dermatoscopy and Reflectance Confocal Microscopy Correlations in Nonmelanocytic Disorders.

Dermatol Clin 2018 Oct 16;36(4):487-501. Epub 2018 Aug 16.

Dermatology Clinic, University of Catania, Via Santa Sofia 78, Catania 95123, Italy.

Dermatoscopy and in vivo reflectance confocal microscopy are noninvasive techniques that provide a horizontal approach, with an en face view of the skin structures. Both techniques assist in the clinical diagnosis of a variety of inflammatory and infectious cutaneous disorders. In many cases, they have shown concordance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183108
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http://dx.doi.org/10.1016/j.det.2018.05.015DOI Listing
October 2018
21 Reads

Dermoscopy of Common Inflammatory Disorders.

Dermatol Clin 2018 Oct 31;36(4):359-368. Epub 2018 Jul 31.

1st Department of Dermatology - Venereology, State Clinic of Dermatology, Aristotle University of Thessaloniki, Hospital of Skin and Venereal Diseases, 124 Delfon Street, Thessaloniki 54643, Greece. Electronic address:

In addition to its "traditional" application for the early diagnosis of melanoma and nonmelanoma skin cancers, dermoscopy gains appreciation in fields beyond dermato-oncology. Nowadays, dermoscopy has been established as a reliable adjunctive tool to the everyday clinical practice of general dermatology. Morphology and distribution of vascular structures, background colors, follicular abnormalities, and the presence of scales are important features that should be evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183107
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http://dx.doi.org/10.1016/j.det.2018.05.003DOI Listing
October 2018
19 Reads

Autoimmune skin disease among dermatology outpatients in Botswana: a retrospective review.

Int J Dermatol 2019 Jan 31;58(1):50-53. Epub 2018 Aug 31.

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Background: There is a paucity of data describing autoimmune skin diseases in sub-Saharan Africa and in HIV positive cohorts. We describe the incidence of autoimmune skin diseases in public dermatology clinics in Botswana.

Methods: New patient records from public dermatology clinics were reviewed retrospectively for the period of September 2008 to December 2015. Read More

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http://dx.doi.org/10.1111/ijd.14201DOI Listing
January 2019
28 Reads
1.230 Impact Factor

Prevalence of Pruritus in Cutaneous Lupus Erythematosus: Brief Report of a Multicenter, Multinational Cross-Sectional Study.

Biomed Res Int 2018 25;2018:3491798. Epub 2018 Jul 25.

Department of Dermatology, University of Rzeszow, Rzeszow, Poland.

Pruritus is an important symptom frequently accompanying various inflammatory skin conditions. Some recent data have indicated that it may also be associated with autoimmune connective tissue diseases, including systemic sclerosis and dermatomyositis; however, studies on the prevalence and clinical characteristics of pruritus in CLE are limited. We have performed a multinational, prospective, cross-sectional study in order to assess the prevalence and intensity of pruritus in adult patients suffering from various subtypes of CLE. Read More

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http://dx.doi.org/10.1155/2018/3491798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083500PMC
January 2019
37 Reads

MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus.

J Invest Dermatol 2019 Jan 18;139(1):51-61. Epub 2018 Aug 18.

Department of Medicine, Systemic Autoimmune Diseases Unit, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.

Cutaneous lupus erythematosus is a common and disfiguring manifestation in systemic lupus erythematosus. Subacute cutaneous lupus erythematosus and discoid lupus erythematosus (DLE) are the most prevalent forms. Despite sharing histological similarities, clinically they differ in their course and prognosis, suggesting different pathogenesis. Read More

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http://dx.doi.org/10.1016/j.jid.2018.07.026DOI Listing
January 2019
7 Reads

CyclinD1 Is Useful to Differentiate Langerhans Cell Histiocytosis From Reactive Langerhans Cells.

Am J Dermatopathol 2019 Mar;41(3):188-192

Pediatric Oncology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder characterized by clonal proliferation of neoplastic Langerhans cells (LCs). LC proliferation can also be seen in different reactive dermatosis. CyclinD1 is a downstream marker of mitogen-activated protein (MAP) kinase pathway, which is often activated in LCH. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001250DOI Listing
March 2019
1 Read
1.430 Impact Factor

Rapamycin for refractory discoid lupus erythematosus.

Dermatol Ther 2018 09 14;31(5):e12631. Epub 2018 Aug 14.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

Generalized discoid lupus erythematosus can pose a therapeutic challenge for dermatologists. Current treatment emphasizes photoprotection, topical and systemic steroids, and steroid-sparing immunosuppressive agents if necessary. Rapamycin, also known as sirolimus, selectively inhibits mammalian target of rapamycin, a regulatory kinase responsible for multiple signal transduction pathways. Read More

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http://dx.doi.org/10.1111/dth.12631DOI Listing
September 2018
3 Reads

Ocular Involvement in Systemic Lupus Erythematosus: The Experience of Two Tertiary Referral Centers.

Ocul Immunol Inflamm 2018 10;26(8):1154-1165. Epub 2018 Aug 10.

b Department of Biomedical Sciences and Human Oncology , University of Bari Medical School , Bari , Italy.

Purpose: To assess the prevalence of the ocular manifestations related to the disease and/or ascribable to the administration of potentially toxic drugs in a cohort of 98 patients with systemic lupus erythematosus (SLE).

Methods: Retrospective, observational study reporting the experience of two tertiary referral centers.

Results: Overall, an ocular involvement was detected in 29 patients (29. Read More

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http://dx.doi.org/10.1080/09273948.2018.1501495DOI Listing
December 2018
2 Reads

Damage accrual in systemic lupus erythematosus in Dominicans in New York City and the Dominican Republic.

Lupus 2018 Oct 9;27(12):1989-1995. Epub 2018 Aug 9.

1 Columbia University College of Physicians and Surgeons, New York, USA.

Objectives Hispanics with systemic lupus erythematosus (SLE) in the United States have more severe disease and damage accrual compared with whites. Data on Hispanics of similar ancestry in geographically different locations is limited but essential in defining genetic and environmental factors for SLE. This study evaluates SLE disease burden in two Dominican communities, Washington Heights in New York City (NYC) and Santiago in the Dominican Republic (DR). Read More

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http://dx.doi.org/10.1177/0961203318791764DOI Listing
October 2018
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Coexistence of Tumid Lupus Erythematosus and Discoid Lupus Erythematosus.

Actas Dermosifiliogr 2019 Apr 30;110(3):253-255. Epub 2018 Jul 30.

Servicio de Dermatología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

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http://dx.doi.org/10.1016/j.ad.2018.02.023DOI Listing
April 2019
2 Reads

Hardness and Painful Lesion of the Breast.

Acta Dermatovenerol Croat 2017 Dec;25(4):305-306

Alejandro Vilas Sueiro, MD, Department of Dermatology, Naval Hospital, University Hospital Complex of Ferrol, Avenida Residencia SN, 15405 Ferrol (A Coruña), Spain;

Dear Editor, Lupus panniculitis or lupus profundus is a rare inflammatory complication found in patients with systemic lupus erythematosus (SLE), or discoid lupus erythematosus (DLE) (1). When the breast is involved, the term lupus mastitis (LM) is used. This disease involving the breast is rare, and the lesions may precede, coincide with, or occur later than the onset of other lupus lesions. Read More

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December 2017
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Atrophic and Annular Scarring Alopecia of the Scalp as a Finding in Underlying Systemic Sarcoidosis.

Acta Dermatovenerol Croat 2017 Dec;25(4):298-299

Dario Didona, MD, Prima Divisione Dermatologica , Istituto Dermopatico dell'Immacolata-IRCCS, Via dei Mont di Creta 104 , 00167 Rome, Italy;

Cutaneous sarcoidosis is not an uncommon disorder, and the skin can be the sole manifestation in about 10% of patients. However, when the involved anatomical area of the cutaneous sarcoidosis is the scalp and it presents as a scarring alopecia, there is an increased risk of a systemic disease (1,2). A 79-year-old Caucasian male patient presented to our Institute with annular and painless plaques of the scalp, with variable diameter, showing a reddish and yellowish color (Figure 1, a). Read More

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December 2017
15 Reads