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    3478 results match your criteria Lupus Erythematosus Discoid

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    Squamous Cell Carcinoma in Discoid Lupus Erythematosus.
    Indian J Dermatol Venereol Leprol 1982 Jul-Aug;48(4):218-220
    A case of Squamous cell Carcinoma arising in discoid lupus erythematosus of 10 years duration is described. The constant exposure to U-V rays in sunlight, in addition to the chronic hypoxidosis in the scar resulting from chronic discoid iupus erythematosus, is assumed to induce malignant degeneration. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Association study between the TP53 Rs1042522G/C polymorphism and susceptibility to systemic lupus erythematosus in a Chinese Han population.
    Rheumatol Int 2017 Feb 9. Epub 2017 Feb 9.
    Department of Information, The Second Hospital of Anhui Medical University, 678 Furong Road Hefei, Anhui, 230601, China.
    Tumour suppressor protein 53 (p53) plays a central role in apoptosis, cell proliferation and death. Previously studies found contribution of functional p53 Arg72Pro polymorphism (TP53 rs1042522G/C polymorphism) in the development of systemic lupus erythematosus (SLE) remains controversial. In this study, for the first time, we evaluated its association with SLE in a Chinese Han population. Read More

    A retrospective study comparing histopathological and immunopathological features of nasal planum dermatitis in 20 dogs with discoid lupus erythematosus or leishmaniosis.
    Vet Dermatol 2017 Jan 29. Epub 2017 Jan 29.
    Veterinaria Cetego, Via M.C. Cetego 20, 00177, Roma, Italy.
    Background: In areas endemic for leishmaniosis, discoid lupus erythematosus (DLE) and canine leishmaniosis (CanL) are the most common differential diagnoses for nasal planum erosive-ulcerative dermatitis in dogs.

    Hypothesis/objective: To compare histopathological and immunopathological features of canine nasal planum erosive-ulcerative dermatitis with depigmentation due to DLE or CanL.

    Animals: Nasal planum biopsies from dogs with nasal planum loss of architecture, depigmentation, swelling, erosions or ulcerations due to DLE (n = 14) or CanL (n = 6). Read More

    High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study.
    J Immunol Res 2017 3;2017:3972706. Epub 2017 Jan 3.
    Department of Dermatology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
    Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control group. Additionally, we intended to determine the differences of sociodemographic and clinical data of the DLE patients with MetS compared to the patients without MetS. Read More

    Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti-Interferon-γ Antibody, in Subjects with Discoid Lupus Erythematosus.
    Arthritis Rheumatol 2017 Jan 24. Epub 2017 Jan 24.
    Amgen Inc., Thousand Oaks, CA.
    Objective: Interferon (IFN)-γ is implicated in the pathogenesis of discoid lupus erythematosus (DLE). This study evaluated a single dose of AMG 811, an anti-IFN-γ antibody, in subjects with DLE.

    Methods: This was a phase 1, randomized, double-blind, placebo-controlled, crossover study (sequence 1: AMG 811 followed by placebo; sequence 2: placebo followed by AMG 811). Read More

    ANA-Negative Presentation of SLE in Man with Severe Autoimmune Neutropenia.
    Case Rep Med 2016 19;2016:6853936. Epub 2016 Dec 19.
    University of California San Diego School of Medicine, La Jolla, CA, USA.
    Background. Systemic lupus erythematosus (SLE) is a chronic, inflammatory, connective tissue disease that commonly affects the joints and a variety of organs due to an overactivation of the body's immune system. There is wide heterogeneity in presentation of SLE patients, including lung, central nervous system, skin, kidney, and hematologic manifestations. Read More

    Oral lichenoid lesions: distinguishing the benign from the deadly.
    Mod Pathol 2017 Jan;30(s1):S54-S67
    Professor Emeritus, Emory University School of Medicine: Atlanta Oral Pathology, Decatur, GA, USA.
    Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus. Read More

    Autoimmune collagen vascular diseases: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):678-689. Epub 2016 Jul 9.
    Assistant Professor of Dermatology, University of Connecticut School of Medicine, Farmington, CT.
    Morphea, dermatomyositis (DM), and discoid lupus erythematosus (DLE) are autoimmune collagen vascular diseases that can present at any age. In all three of these diseases, the tenants of diagnosis and treatment are largely the same in both children and adults, with a few notable differences. Children with morphea are more likely to present with the linear subtype and have a higher incidence of extracutaneous manifestations. Read More

    The Relationship Between Disease Severity in Discoid Lupus Erythematosus and Quality of Life.
    Br J Dermatol 2016 Dec 10. Epub 2016 Dec 10.
    Department of Dermatology, Counties Manukau District Health Board, Private Bag, 93311, Auckland, New Zealand.
    Discoid Lupus Erythematosus (DLE) is a chronic scarring skin condition and a subset of cutaneous lupus as defined by Gilliam and Sontheimer (1). It is a common form of cutaneous lupus in a European population (CLE) (2). The objective of this study was to assess the effect of DLE severity on quality of life (QOL). Read More

    Comparison of ethnicity, gender, age of onset and outcome in South Africans with systemic lupus erythematosus.
    Lupus 2016 Nov 10. Epub 2016 Nov 10.
    Department of Nephrology, Inkosi Albert Luthuli Central Hospital, and School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.
    Ethnicity, gender and age of onset are reported to influence the expression and outcome of systemic lupus erythematosus. We studied a multi-ethnic cohort of 408 South Africans (91.2% females) comprising 237 (58. Read More

    Lenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus.
    Lupus 2016 Nov 10. Epub 2016 Nov 10.
    Department of Pediatrics, Duke University Medical Center, Durham, USA.
    Objective: Cutaneous manifestations of pediatric systemic lupus erythematosus cause significant morbidity. Lenalidomide, a thalidomide analogue, has shown promise treating cutaneous lupus erythematosus in adults. Our objective was to evaluate lenalidomide's efficacy and safety in treating refractory cutaneous manifestations of pediatric systemic lupus erythematosus. Read More

    Frequency and predictors of the lupus low disease activity state in a multi-national and multi-ethnic cohort.
    Arthritis Res Ther 2016 Nov 9;18(1):260. Epub 2016 Nov 9.
    The University of Melbourne, Melbourne, Australia.
    Background: Systemic lupus erythematosus (SLE) is a chronic heterogeneous disease with considerable burden from disease activity and damage. A novel clinical treatment target in the form of the lupus low disease activity state (LLDAS) has been recently reported, with retrospective validation showing that time spent in LLDAS translates to reduced damage accrual. The objectives of this study were to describe the frequency and identify the predictors of attaining LLDAS in a large multinational cohort of patients with SLE. Read More

    Update on Lupus Nephritis.
    Clin J Am Soc Nephrol 2016 Nov 7. Epub 2016 Nov 7.
    Department of Internal Medicine, The Ohio State Wexner Medical Center, Columbus, Ohio
    SLE is a chronic inflammatory disease that affects the kidneys in about 50% of patients. Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite potent anti-inflammatory and immunosuppressive therapies still ends in CKD or ESRD for too many patients. This review highlights recent updates in our understanding of disease epidemiology, genetics, pathogenesis, and treatment in an effort to establish a framework for lupus nephritis management that is patient-specific and oriented toward maintaining long-term kidney function in patients with lupus. Read More

    Features of 847 Childhood-Onset Systemic Lupus Erythematosus Patients in Three Age Groups at Diagnosis: A Brazilian Multicenter Study.
    Arthritis Care Res (Hoboken) 2016 Nov 6;68(11):1736-1741. Epub 2016 Oct 6.
    Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
    Objective: To evaluate demographic data and clinical and laboratory features at disease diagnosis in 3 different age groups of childhood-onset systemic lupus erythematosus (SLE): group A, early-onset (<6 years); group B, school age (≥6 to <12 years); and group C, adolescent (≥12 to <18 years).

    Methods: This was a Brazilian multicenter cohort retrospective study in 10 pediatric rheumatology centers, including 847 childhood-onset SLE patients.

    Results: Patients were divided into 3 groups: group A with 39 patients (4%), group B with 395 patients (47%), and group C with 413 patients (49%). Read More

    Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases).
    Vet Dermatol 2016 Dec 16;27(6):488-e131. Epub 2016 Oct 16.
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
    Background: Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized.

    Hypothesis/objectives: We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE.

    Methods: Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis). Read More

    Estrogen receptor alpha gene ( ESR1) polymorphism can contribute to clinical findings in systemic lupus erythematosus patients.
    Lupus 2017 Mar 29;26(3):294-298. Epub 2016 Sep 29.
    1 Federal University of Santa Catarina, Department of Cell Biology, Embryology and Genetics, Florianopolis, Brazil.
    Background Estrogens have a modulatory effect on several immune responses, many of which are correlated to autoimmune diseases. Estrogens act through binding to their receptors, and an overexpression of these receptors has been identified in patients with different autoimmune diseases. Here we analyzed the association of a putative functional genetic variant in the main estrogen receptor (ERα) gene ( ESR1), and the susceptibility to clinical findings and severity of SLE. Read More

    Eccrine Duct Dilation as a Marker of Cicatricial Alopecia.
    Am J Dermatopathol 2016 Sep 26. Epub 2016 Sep 26.
    Departments of *Pathology, and †Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL; and ‡Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.
    Background: Eccrine duct dilation (EDD) and syringoma-like sweat duct proliferation have been described as reactive changes occurring in a variety of skin conditions. However, extensive evaluation of EDD in scalp biopsies performed for alopecia has not been performed.

    Methods: We retrospectively examined 129 cases of cicatricial alopecia (lichen planopilaris, central centrifugal cicatricial alopecia, and discoid lupus erythematosus) and 130 cases of noncicatricial alopecias (androgenetic alopecia, telogen effluvium, and alopecia areata) for the presence of EDD. Read More

    Addison Disease and Discoid Lupus Erythematosus: A Rare Association of Polyglandular Autoimmune Syndrome Type II.
    J Clin Rheumatol 2016 Oct;22(7):382-3
    From the *Corporal Michael J. Crescenz Medical Center; †Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania; and ‡Department of Dermatology, Thomas Jefferson University Sidney Kimmel School of Medicine, Philadelphia, PA.

    Lupus Skin Is Primed for IL-6 Inflammatory Responses through a Keratinocyte-Mediated Autocrine Type I Interferon Loop.
    J Invest Dermatol 2017 Jan 16;137(1):115-122. Epub 2016 Sep 16.
    Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:
    Cutaneous lupus erythematosus is a disfiguring and common manifestation in systemic lupus erythematosus, and the etiology of this predisposition for cutaneous inflammation is unknown. Here, we sought to examine the keratinocyte as an important source of IL-6 and define the mechanism for its increased production in cutaneous lupus erythematosus. Evaluation of discoid and subacute cutaneous lupus erythematosus lesions showed significant epidermal up-regulation of IL-6 compared with control via real-time PCR and immunohistochemistry. Read More

    Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report.
    BMC Dermatol 2016 Sep 20;16(1):14. Epub 2016 Sep 20.
    Cancer Treatment and Research Center, Mail Code 7876, 7979 Wurzbach Road, San Antonio, TX, 78229-4427, USA.
    Background: Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Chronic cutaneous lupus erythematosus (CCLE) is an autoimmune disease that is associated with autoantibody production and T-cell dysfunction. Cutaneous manifestations of sarcoidosis may mimic CCLE and vice versa making it difficult to reach a diagnosis clinically. Read More

    A practical clinical recording system for cases with desquamative gingivitis.
    Br J Dermatol 2016 Sep 17. Epub 2016 Sep 17.
    WHO Collaborating Centre for Oral Health-General Health; and UCL, UK.
    The most frequent autoimmune disorders that involve the oral mucosae are lichen planus, pemphigoid, pemphigus, epidermolysis bullosa acquisita, erythema multiforme, discoid lupus erythematosus and chronic ulcerative stomatitis, affected individuals presenting with variable oral lesions; mainly(1-3) hyperkeratosis, erythema, blisters, erosions and ulcerations. The gingival tissues are commonly involved, not least because of decreases in oral hygiene(4) but the gingiva can be the unique site of onset or the first manifestation of the disorder(5) often as "desquamative gingivitis" (DG).(3,6,7)(This article is protected by copyright. Read More

    Mutilating Squamous Cell Carcinoma: A Rare Complication of an Early Plaque of Discoid Lupus Erythematosus.
    West Indian Med J 2016 Feb 22. Epub 2016 Feb 22.
    Department of Dermatology and Venereology, Pt BDS PGIMS, Rohtak, Haryana, India.
    Cutaneous Squamous cell carcinoma (SCC) is the second most common form of non-melanotic skin cancer after basal cell carcinoma (BCC). It is a well-known complication of discoid lupus erythematosus (DLE) and usually favours the depigmented lesions located over sun-exposed areas. The clinical course of this complication may be aggressive, with a high risk of mortality. Read More

    Dermoscopy in General Dermatology: A Practical Overview.
    Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
    Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

    Squamous Cell Cancer Arising in an African American Male Cheek from Discoid Lupus: A Rare Case and Review of the Literature.
    Case Rep Surg 2016 17;2016:9170424. Epub 2016 Aug 17.
    Department of Head & Neck Surgery, Kaiser Fontana/Ontario, 9961 Sierra Avenue, Fontana, CA 92335, USA.
    A 50-year-old African American male with Discoid Lupus Erythematosus (DLE) presented to the dermatology clinic for a rapidly enlarging left cheek mass. The mass failed to resolve with conservative measures. A biopsy revealed poorly differentiated Squamous Cell Carcinoma (SCC). Read More

    Apoptosis of keratinocytes and serum DNase I activity in patients with cutaneous lupus erythematosus: relationship with clinical and immunoserological parameters.
    J Eur Acad Dermatol Venereol 2016 Aug 24. Epub 2016 Aug 24.
    Department of Dermatovenereology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
    Background: Dysregulation of apoptosis has an important role in the induction of autoimmunity.

    Objective: To evaluate the influence of keratinocyte apoptosis and deoxyribonuclease I (DNase I) activity on the clinical and immunoserological parameters of cutaneous lupus erythematosus (CLE).

    Methods: We studied 69 CLE patients (39 with discoid LE (DLE), 12 with subacute CLE (SCLE), 12 with acute and 6 with intermittent CLE). Read More

    Cutaneous characteristics and association with antinuclear antibodies in 402 patients with different subtypes of lupus erythematosus.
    J Eur Acad Dermatol Venereol 2016 Dec 19;30(12):2097-2104. Epub 2016 Jul 19.
    Connective tissue disease research unit of the Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, Bochum, Germany.
    Background: Lupus erythematosus (LE) is an autoimmune disease characterized by a heterogeneous spectrum of skin manifestations and organ affection, and is frequently associated with serum autoantibodies, which mostly remain positive through the course of the disease. The classification of LE is still a controversial topic.

    Objectives: To examine the prevalence and long-term course of autoantibodies in patients with cutaneous LE (CLE) and/or systemic LE (SLE) treated in the outpatient clinic for connective tissue diseases of the department of Dermatology in Bochum, Germany. Read More

    Atypical clinical presentation of primary and secondary cutaneous follicle center lymphoma (FCL) on the head characterized by macular lesions.
    J Am Acad Dermatol 2016 Nov 2;75(5):1000-1006. Epub 2016 Jul 2.
    Research Unit of Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria. Electronic address:
    Background: Primary cutaneous follicle center lymphoma (pcFCL) usually presents with reddish nodules, plaques, and tumors on the head and neck or the back.

    Objective: We sought to describe a peculiar clinical presentation of pcFCL and secondary cutaneous follicle center lymphoma (FCL).

    Methods: We report a series of 13 patients (7 male and 6 female; median age 58 years, mean age 58. Read More

    Relevance of trichoscopy in the differential diagnosis of alopecia: A cross-sectional study from North India.
    Indian J Dermatol Venereol Leprol 2016 Nov-Dec;82(6):651-658
    Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
    Background: Trichoscopy is an office tool used in the diagnosis of alopecia but its utility has not been assessed.

    Objectives: To compare the trichoscopic characteristics of different types of alopecia, identify features of diagnostic value, and to determine the utility of trichoscopy in the diagnosis of alopecia.

    Methods: A descriptive cross-sectional study was performed in patients with alopecia. Read More

    Lupus Damage and Waist Circumference as the Independent Risk Factors for Cardiovascular Disease in SLE Patients from Phramongkutklao Hospital.
    J Med Assoc Thai 2016 Mar;99(3):290-300
    Background: Cardiovascular disease (CVD) has been reported to be a major cause of both morbidity and premature mortality in systemic lupus erythematosus (SLE) patients.

    Objective: To determine the prevalence of cardiovascular disease and associated risk factors in Thai SLE patients from Phramongkutklao Hospital, Thailand.

    Material And Method: A retrospective cross-sectional study was performed to investigate the frequency of CVD in SLE patients in Phramongkutklao Hospital on the basis of medical record documentation. Read More

    Lupus erythematosus and localized scleroderma coexistent at the same sites: a rare presentation of overlap syndrome of connective-tissue diseases.
    Cutis 2016 May;97(5):359-63
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, USA.
    Overlap syndromes are known to occur with connective-tissue diseases (CTDs). Rarely, the overlap occurs at the same tissue site. We report the case of a patient with clinical and histopathologic findings consistent with the presence of discoid lupus erythematosus (DLE) and localized scleroderma within the same lesions. Read More

    Advances in the treatment of cutaneous lupus erythematosus.
    Lupus 2016 Jul;25(8):830-7
    Department of Dermatology, University of Bonn, Germany.
    Lupus erythematosus (LE) is a multifactorial autoimmune disease with clinical manifestations of differing severity which may present with skin manifestations as primary sign of the disease (cutaneous lupus erythematosus, CLE) or as part of a disease spectrum (systemic lupus erythematosus, SLE). To date, no drugs are approved specifically for the treatment of CLE and only single agents have been applied in randomized controlled trials. Therefore, topical and systemic agents are used "off-label", primarily based on open-label studies, case series, retrospective analyses, and expert opinions. Read More

    Podoplanin Expression Is Correlated With the Progression of Chronic Discoid Lupus Erythematosus to Lip Squamous Cell Carcinoma.
    Int J Surg Pathol 2016 Oct 29;24(7):595-9. Epub 2016 May 29.
    Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Chronic lip discoid lupus erythematosus (DLE) is a potentially malignant disorder that can develop into lip squamous cell carcinoma (LSCC). Podoplanin is a specific marker for lymphatic endothelial cells and plays a role in cancer progression. The objective of this study was to determine the immunoexpression of podoplanin in samples of patients with DLE and its correlation with the risk of progression to LSCC. Read More

    Ethnic differences in the epidemiology of cutaneous lupus erythematosus in New Zealand.
    Lupus 2016 Nov 11;25(13):1497-1502. Epub 2016 Jul 11.
    2 Department of Epidemiology and Biostatistics, The University of Auckland, Auckland, New Zealand.
    Background The prevalence and variation by ethnicity of cutaneous lupus in New Zealand is not known. Therefore, a cross-sectional study to determine the prevalence and variation by ethnicity of cutaneous lupus in the ethnically diverse community of South Auckland, New Zealand, was undertaken. Methods Multiple sources were examined to determine the prevalence of acute cutaneous lupus erythematosus, subacute cutaneous erythematosus and discoid lupus erythematosus. Read More

    Early discoid lupus erythematosus protects against renal disease in patients with systemic lupus erythematosus: longitudinal data from a large Latin American cohort.
    Lupus 2017 Jan 26;26(1):73-83. Epub 2016 May 26.
    Division of Rheumatology, Emory School of Medicine, Atlanta, USA
    Objectives: The objective of this study was to examine whether early discoid lupus erythematosus (DLE) would be a protective factor for further lupus nephritis in patients with systemic lupus erythematosus (SLE).

    Methods: We studied SLE patients from GLADEL, an inception longitudinal cohort from nine Latin American countries. The main predictor was DLE onset, which was defined as physician-documented DLE at SLE diagnosis. Read More

    Flame Hair.
    Skin Appendage Disord 2015 Sep 2;1(2):105-9. Epub 2015 Sep 2.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.
    Background: 'Flame hairs' is a trichoscopic feature described as hair residue from pulling anagen hairs in trichotillomania.

    Objective: To detect whether flame hairs are present in other hair loss disorders.

    Methods: We retrospectively, independently and blindly reviewed the trichoscopic images of 454 consecutive patients with alopecia areata (99 cases), trichotillomania (n = 20), acute chemotherapy-induced alopecia (n = 6), acute radiotherapy-induced alopecia (n = 2), tinea capitis (n = 13), lichen planopilaris (n = 33), frontal fibrosing alopecia (n = 60), discoid lupus erythematosus (n = 30), dissecting cellulitis (n = 11), central centrifugal cicatricial alopecia (n = 94) and traction alopecia (n = 86) for the presence of flame hairs. Read More

    Severe recalcitrant cutaneous manifestations in systemic lupus erythematosus successfully treated with fumaric acid esters.
    Br J Dermatol 2016 Apr 23. Epub 2016 Apr 23.
    The Royal Free London NHS Foundation Trust, Department of Dermatology.
    Fumaric acid esters (FAE) have proven efficacy in the treatment of psoriasis and have been in use for decades. More recently, as their mechanism of action and abundant immunomodulatory effects become clearer, potential benefits in other inflammatory skin conditions are becoming increasingly recognized. The use of FAE as combination systemic therapy has not been well studied, and data on safety and efficacy in this scenario is lacking. Read More

    Review of treatment for discoid lupus erythematosus.
    Dermatol Ther 2016 Jul 12;29(4):274-83. Epub 2016 Apr 12.
    Harvard Medical School, Boston, Massachusetts.
    Discoid lupus erythematosus (DLE) is a chronic cutaneous disease characterized by inflammatory plaques that, in the absence of prompt diagnosis and treatment, may lead to disfiguring scarring and skin atrophy. However, there is limited evidence for which treatments are most effective. Currently, no medications have been approved specifically for the treatment of DLE. Read More

    Antiphospholipid syndrome with subsequent chronic discoid lupus erythematosus: a case report.
    G Ital Dermatol Venereol 2016 Apr;151(2):203-5
    Department of Dermatology, University of Sassari, Sassari, Italy -
    Antiphospholipid syndrome is an immune-mediated acquired disorder characterized by vein and/or artery thromboses and obstetrical complications associated with the presence of antiphospholipid antibodies in the blood. aPL include anticardiolipin antibodies (aCL), antiβ2glycoproteinI (antiβ2GPI), and lupus anticoagulant (LAC). A primitive idiopathic form and a secondary form of APS are recognized. Read More

    Validity of trichoscopy in the diagnosis of primary cicatricial alopecias.
    Int J Dermatol 2016 Oct 7;55(10):1106-14. Epub 2016 Apr 7.
    Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: There are limited data on the validity of dermatoscopy in primary cicatricial alopecias (PCAs) and its subtypes, including lichen planopilaris and discoid lupus erythematosus. Trichoscopic features of PCAs, their prevalence, and validity were evaluated in this study.

    Methods: One hundred patients with PCA underwent dermatoscopy. Read More

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