3,648 results match your criteria Lupus Erythematosus Discoid


Practice-Based Differences in Pediatric Discoid Lupus Erythematosus.

Br J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Northwestern University Feinberg School of Medicine, Department of Dermatology and Pediatrics, Chicago, Illinois, United States.

Background: Children with discoid lupus erythematosus (DLE) are at risk for disfigurement and progression to systemic lupus erythematosus (SLE). Consensus is lacking regarding optimal care of children with DLE.

Objectives: We compared practice patterns among pediatric dermatologists/rheumatologists treating pediatric DLE. Read More

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http://dx.doi.org/10.1111/bjd.17780DOI Listing
February 2019

Cutaneous lupus associated with pembrolizumab therapy for advanced melanoma: a report of three cases.

Melanoma Res 2019 Feb 11. Epub 2019 Feb 11.

Departments of Dermatology.

Checkpoint blockade immunotherapy has revolutionized the treatment of advanced melanoma, with impressive survival benefits attained through upregulation of the anticancer immune response. Blockade of regulatory checkpoint molecules can, however, also result in aberrant immune activation leading to undesirable inflammation and autoimmunity. Although many genetic determinants have been described in patients with primary autoimmune diseases, it is uncertain whether patients developing autoimmune skin disease as an adverse effect of anti-PD-1 therapy share the same genetic risks. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000587DOI Listing
February 2019

A Study of the Histopathological Features of Alopecias on Transverse Sections of Scalp Biopsies.

Indian J Dermatol 2019 Jan-Feb;64(1):47-54

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Transverse sections of scalp biopsies are performed for the assessment of alopecias and are considered advantageous over vertical sections.

Aim: The aim was to study the histopathological features of alopecias on transverse sections of scalp biopsies.

Methods: It was a descriptive study. Read More

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http://dx.doi.org/10.4103/ijd.IJD_477_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340243PMC
February 2019
1 Read

Intravenous immunoglobulin G use in patients with chronic inflammatory demyelinating polyneuropathy: An uncommon cause of drug-induced discoid lupus erythematosus.

Australas J Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Dermatology, Temple University Hospital, Philadelphia, Pennsylvania, USA.

Drug-induced chronic cutaneous lupus erythematosus, or drug-induced discoid lupus erythematosus, is a rare cutaneous phenomenon. Various medications have been associated with drug-induced discoid lupus erythematosus including fluorouracile agents, especially tegafur and uraciltegafur, and TNF-α antagonists such as infliximab or etanercept. Recent literature has described a case series of six patients receiving IgG immunoglobulin for chronic inflammatory demyelinating polyneuropathy with subsequent presentations of discoid lupus erythematosus. Read More

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http://dx.doi.org/10.1111/ajd.12998DOI Listing
February 2019
1 Read

Increased level of B cell differentiation factor in systemic lupus erythematosus patients.

J Genet Eng Biotechnol 2018 Dec 30;16(2):467-471. Epub 2018 May 30.

Medical physiology Department Medical Division National Research Center, 33 El-Bohouth Street, Dokki, POB:12311, Cairo, Egypt.

Most autoimmune disease are driven by a dysfunction in T and B cells, but B cells are still an interesting area of research, perturbations in their development are implicated in autoimmune diseases. B cell differentiating factor (BCDF) plays a part in the differentiation of B cells. The aim was To assess the levels of BCDF, IgM and IgG in SLE patients and whether they have any peculiarity in the clinical context of SLE. Read More

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http://dx.doi.org/10.1016/j.jgeb.2018.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353854PMC
December 2018
1 Read

Direct immunofluorescence findings in cicatricial alopecia: A retrospective study of 155 cases.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):103-106

Department of Dermatology, Maulana Azad Medical College, New Delhi, India.

Objectives: To study the direct immunofluorescence (DIF) in cicatricial alopecia (CA) patients.

Materials And Methods: Approximately, 155 skin biopsies from CA patients examined over 7 years (2009-2015). Special stains and Hematoxylin and Eosin were performed, and final histopathological diagnosis was made. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_428_18DOI Listing
February 2019
2 Reads

Validation and Reliability of a Disease-Specific Quality of Life Measure in Patients with Cutaneous Lupus Erythematosus: CLEQoL.

Br J Dermatol 2019 Jan 13. Epub 2019 Jan 13.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Cutaneous lupus erythematosus (CLE) is a potentially disfiguring, chronic autoimmune disease with extremely variable skin manifestations, negatively affecting quality of life (QoL) of patients. Patient-reported outcome (PRO) measures used in assessing QoL in CLE patients have been either generic or developed without input from patients with CLE.

Objectives: To demonstrate the reliability and validity of a disease-specific QoL measure for CLE - the cutaneous lupus erythematosus quality of life (CLEQoL). Read More

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http://doi.wiley.com/10.1111/bjd.17636
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http://dx.doi.org/10.1111/bjd.17636DOI Listing
January 2019
3 Reads

Serum Transforming Growth Factor-Beta 1 Level in Egyptian Systemic Lupus Erythematosus Patients.

Arch Rheumatol 2018 Sep 31;33(3):358-366. Epub 2018 Jul 31.

Department of Internal Medicine, Cairo University, Cairo, Egypt.

Objectives: This study aims to assess the role of transforming growth factor-beta 1 (TGF-β1) in systemic lupus erythematosus (SLE).

Patients And Methods: The study included 40 female SLE patients (mean age 25.5±6. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2018.6405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328217PMC
September 2018
1 Read

Immunological methods for the diagnosis of oral mucosal diseases.

Br J Dermatol 2018 Dec 26. Epub 2018 Dec 26.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Medicine of West China Hospital of Stomatology, Sichuan University, Chengdu, China.

The immunological methods have been widely used in autoimmune blistering diseases (AIBDs) of the oral mucosa, which can also be adopted as auxiliary diagnostic tools in oral lichen planus (OLP) and discoid lupus erythematosus (DLE). AIBDs, characterized by autoantibodies against structural proteins of keratinocytes or the basement membrane zone, clinically presents as blisters and erosions of the oral mucosa. When atypical lesions occur, OLP or DLE may be confused with AIBDs. Read More

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http://dx.doi.org/10.1111/bjd.17589DOI Listing
December 2018

[Chloroquine retinopathy].

Ned Tijdschr Geneeskd 2018 Dec 17;163. Epub 2018 Dec 17.

LUMC, afd. Dermatologie, Leiden.

Background: Chloroquine (CQ) and hydroxychloroquine (HCQ) can induce retinopathy. The risk of this severe, irreversible ophthalmological complication significantly increases with duration of treatment (> 5 years) and dosage of medication (for CQ > 2.3 mg/kg/day and HCQ > 5. Read More

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December 2018
6 Reads

REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A).

Ann Rheum Dis 2019 Feb 18;78(2):238-248. Epub 2018 Dec 18.

Laboratory of Immune Regulation and Tolerance, Autoimmunity and Inflammation, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

Objectives: The release of neutrophil extracellular traps (NETs) represents a novel neutrophil effector function in systemic lupus erythematosus (SLE) pathogenesis. However, the molecular mechanism underlying NET release and how NETs mediate end-organ injury in SLE remain elusive.

Methods: NET formation and NET-related proteins were assessed in the peripheral blood and biopsies from discoid lupus and proliferative nephritis, using immunofluorescence, immunoblotting, quantitative PCR and ELISA. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-213181DOI Listing
February 2019
3 Reads

Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia.

Am J Dermatopathol 2018 Dec 10. Epub 2018 Dec 10.

Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Background: Premature desquamation of the inner root sheath (PDIRS) is considered one of the distinctive features in central centrifugal cicatricial alopecia (CCCA). However, PDIRS can be seen in other alopecia subtypes, and its utility in the diagnosis of CCCA has been debated. We aimed to examine a large cohort of alopecia cases for the presence of PDIRS in association with and without inflammation to determine whether PDIRS in noninflamed follicles can be used as a specific marker of CCCA. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001336DOI Listing
December 2018
2 Reads

Detection of DNA Autoantibodies by Electrophoretic Mobility Shift Assay.

Methods Mol Biol 2019 ;1901:133-152

Laboratory for Life Sciences, Tehran, Iran.

Although the presence of antibodies against double-stranded (ds) DNA is considered the serological hallmark of systemic lupus erythematosus (SLE), it is not detected in all SLE patients by routine laboratory tests. Looking at DNA-anti(ds)DNA interaction as one kind of DNA-protein interaction gave us the grounds for a novel type of assay, easy to perform, and providing a direct insight on DNA-anti(ds)DNA IgG interaction. The assay is an application of the electrophoretic mobility shift assay (EMSA) and is based on the observation that the electrophoretic mobility of a DNA-protein complex is typically less than that of free DNA. Read More

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http://link.springer.com/10.1007/978-1-4939-8949-2_11
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http://dx.doi.org/10.1007/978-1-4939-8949-2_11DOI Listing
January 2019
6 Reads

Persistent red and swollen eyelids.

Lancet 2018 10;392(10157):1552

Department of Dermatology, Chitose City Hospital, Chitose, Japan. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)32327-4DOI Listing
October 2018
2 Reads

Systemic Lupus Erythematous: Symptoms and Signs at Initial Presentations.

Antiinflamm Antiallergy Agents Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Rheumatology Department, Ministry of Health and Prevention, PO Box 65522, Dubai. Saudi Arabia.

Systemic lupus erythematosus (SLE) is an autoimmune multisystem inflammatory condition that causes microvascular inflammation with the production of various auto-antibodies that play a major role in its pathogenesis. SLE can affect both sexes, all ages, and all ethnic groups with widespread geographical and socioeconomic backgrounds. Asia encompasses people of many sociocultural backgrounds with diverse ethnic. Read More

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http://dx.doi.org/10.2174/1871523018666181128161828DOI Listing
November 2018
21 Reads

Koebner phenomenon of discoid lupus erythematosus on old tattoos.

Lupus 2018 Nov 28:961203318815578. Epub 2018 Nov 28.

1 Division of Dermatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

The Koebner phenomenon is the development of lesions in traumatized skin, often with spontaneously occurring lesions elsewhere. We report a case of a woman in her 20 s presenting with discoid lesions superimposed on tattoos that she obtained many years ago. Although a few case reports have been published describing development of lesions on red tattoos attributed to photosensitivity, or koebnerization occurring less than a month following tattoo placement, our patient demonstrates a unique delayed development of discoid lesions years after obtaining her tattoos in non-sun exposed skin. Read More

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http://dx.doi.org/10.1177/0961203318815578DOI Listing
November 2018

Frontal Fibrosing Alopecia and Discoid Lupus Erythematosus: More Than a Coincidence.

Actas Dermosifiliogr 2018 Oct 25. Epub 2018 Oct 25.

Unidad de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Campus de la Salud de Granada, Granada, España. Electronic address:

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http://dx.doi.org/10.1016/j.ad.2018.02.033DOI Listing
October 2018
1 Read

[Connective tissue diseases in the hospital setting in Lomé: a retrospective study of 231 cases].

Pan Afr Med J 2018 26;30:176. Epub 2018 Jun 26.

Service de Dermatologie-Vénérologie, Faculté des Sciences de Santé Lomé, Lomé, Togo.

This study aimed to highlight the epidemiological , clinical, therapeutic and evolutionary profile of connective tissue diseases in the hospitals setting in Lomé. We conducted a retrospective and descriptive study from January 1, 1993 to December 30, 2012. We focused on the medical records of patients with connective tissue diseases hospitalized in five Departments of Dermatology and Rheumatology at the Hospitals in Lomé. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.176.14565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235477PMC
December 2018
2 Reads

Clinical Images: Lichen planus pigmentosus and frontal fibrosing alopecia mimicking discoid lupus erythematosus.

Arthritis Rheumatol 2018 Nov 14. Epub 2018 Nov 14.

Corporal Michael J. Crescenz VAMC and University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1002/art.40779DOI Listing
November 2018
2 Reads

Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden.

Psychiatr Genet 2018 Nov 6. Epub 2018 Nov 6.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Aims: In the era of genome-wide association studies, familial risks are used to estimate disease heritability and success in gene identification. We wanted to estimate associations of 42 autoimmune diseases with attention-deficit hyperactivity disorder (ADHD) between individuals and family members.

Participants And Methods: The availability of a Multigeneration Register in Sweden provides reliable access to family data that covers the last century. Read More

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http://dx.doi.org/10.1097/YPG.0000000000000212DOI Listing
November 2018
3 Reads

Alopecias in lupus erythematosus.

Lupus Sci Med 2018 25;5(1):e000291. Epub 2018 Oct 25.

Corporal Michael J Crescenz VAMC, Philadelphia, Pennsylvania, USA.

Several patterns of hair loss can occur in lupus erythematosus (LE). Alopecias which show histological characteristics of LE are LE-specific, and include discoid LE (DLE), diffuse or patchy hair loss in acute LE, subacute cutaneous LE, and rarely tumid LE. Lupus hair in SLE is a poorly characterised entity and may be a form of telogen effluvium. Read More

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http://dx.doi.org/10.1136/lupus-2018-000291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203010PMC
October 2018
2 Reads

A comparative immunohistochemical study of epidermal and dermal/perifollicular Langerhans cell concentration in discoid lupus erythematosus and lichen planopilaris: a cross-sectional study.

Lupus 2018 Dec 30;27(14):2200-2205. Epub 2018 Oct 30.

1 Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: There are times when differentiation between discoid lupus erythematosus (DLE) and lichen planopilaris (LPP) becomes quite challenging clinicopathologically.

Objectives: The aim of this study was to evaluate and compare the concentration, distribution pattern and role of Langerhans cells (LCs), identified by CD1a staining in DLE and LPP.

Methods: Twenty-five specimens of skin biopsies from patients diagnosed with LPP and DLE were included. Read More

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http://dx.doi.org/10.1177/0961203318808587DOI Listing
December 2018

Skin signs in juvenile- and adult-onset systemic lupus erythematosus: clues to different systemic involvement.

Lupus 2018 Nov 18;27(13):2069-2075. Epub 2018 Oct 18.

1 Division of Dermatology, Chulalongkorn University, Bangkok, Thailand.

Objective: We aim to explore the differences of skin signs between juvenile- and adult-onset systemic lupus erythematosus and to identify their associations to the development of systemic involvement.

Methods: A retrospective chart review of 377 systemic lupus erythematosus patients was performed.

Results: In total, 171 patients with juvenile systemic lupus erythematosus and 206 with adult systemic lupus erythematosus were studied. Read More

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http://dx.doi.org/10.1177/0961203318805851DOI Listing
November 2018
3 Reads
2.200 Impact Factor

Chronic cutaneous lupus erythematosus and topical clindamycin.

BMJ Case Rep 2018 Sep 23;2018. Epub 2018 Sep 23.

Dermatology Residency, Affiliated Dermatology, Scottsdale, Arizona, USA.

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http://dx.doi.org/10.1136/bcr-2018-226728DOI Listing
September 2018

[34-Year-Old Patient with Scarred-Scaly Skin Changes].

Authors:
Dieter Krahl

Dtsch Med Wochenschr 2018 09 19;143(19):1361-1362. Epub 2018 Sep 19.

HEIDELBERGHISTO, Heidelberg.

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http://dx.doi.org/10.1055/a-0681-8749DOI Listing
September 2018
1 Read

Canine Cutaneous Lupus Erythematosus: Newly Discovered Variants.

Authors:
Frane Banovic

Vet Clin North Am Small Anim Pract 2019 Jan 15;49(1):37-45. Epub 2018 Sep 15.

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Athens, GA 30605, USA. Electronic address:

As the spectrum of canine cutaneous lupus erythematosus (CLE) variants has expanded markedly in the recent 2 decades, veterinarians are encouraged to become familiar with the characteristic clinical features of CLE variants to permit early diagnosis and appropriate treatment. This article describes the signalment, clinical signs, treatment outcome, and laboratory and histopathology findings of 2 new canine CLE variants, generalized discoid lupus erythematosus and mucocutaneous lupus erythematosus. Read More

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http://dx.doi.org/10.1016/j.cvsm.2018.08.004DOI Listing
January 2019
7 Reads

Usefulness of Pulsed Dye Laser in Cutaneous Lupus Erythematosus.

Actas Dermosifiliogr 2018 Sep 10. Epub 2018 Sep 10.

Departamento de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.

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http://dx.doi.org/10.1016/j.ad.2018.03.020DOI Listing
September 2018
2 Reads

Dermatoscopy and Reflectance Confocal Microscopy Correlations in Nonmelanocytic Disorders.

Dermatol Clin 2018 Oct 16;36(4):487-501. Epub 2018 Aug 16.

Dermatology Clinic, University of Catania, Via Santa Sofia 78, Catania 95123, Italy.

Dermatoscopy and in vivo reflectance confocal microscopy are noninvasive techniques that provide a horizontal approach, with an en face view of the skin structures. Both techniques assist in the clinical diagnosis of a variety of inflammatory and infectious cutaneous disorders. In many cases, they have shown concordance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183108
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http://dx.doi.org/10.1016/j.det.2018.05.015DOI Listing
October 2018
15 Reads

Dermoscopy of Common Inflammatory Disorders.

Dermatol Clin 2018 Oct 31;36(4):359-368. Epub 2018 Jul 31.

1st Department of Dermatology - Venereology, State Clinic of Dermatology, Aristotle University of Thessaloniki, Hospital of Skin and Venereal Diseases, 124 Delfon Street, Thessaloniki 54643, Greece. Electronic address:

In addition to its "traditional" application for the early diagnosis of melanoma and nonmelanoma skin cancers, dermoscopy gains appreciation in fields beyond dermato-oncology. Nowadays, dermoscopy has been established as a reliable adjunctive tool to the everyday clinical practice of general dermatology. Morphology and distribution of vascular structures, background colors, follicular abnormalities, and the presence of scales are important features that should be evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183107
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http://dx.doi.org/10.1016/j.det.2018.05.003DOI Listing
October 2018
14 Reads

Autoimmune skin disease among dermatology outpatients in Botswana: a retrospective review.

Int J Dermatol 2019 Jan 31;58(1):50-53. Epub 2018 Aug 31.

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Background: There is a paucity of data describing autoimmune skin diseases in sub-Saharan Africa and in HIV positive cohorts. We describe the incidence of autoimmune skin diseases in public dermatology clinics in Botswana.

Methods: New patient records from public dermatology clinics were reviewed retrospectively for the period of September 2008 to December 2015. Read More

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http://dx.doi.org/10.1111/ijd.14201DOI Listing
January 2019
22 Reads
1.230 Impact Factor

Prevalence of Pruritus in Cutaneous Lupus Erythematosus: Brief Report of a Multicenter, Multinational Cross-Sectional Study.

Biomed Res Int 2018 25;2018:3491798. Epub 2018 Jul 25.

Department of Dermatology, University of Rzeszow, Rzeszow, Poland.

Pruritus is an important symptom frequently accompanying various inflammatory skin conditions. Some recent data have indicated that it may also be associated with autoimmune connective tissue diseases, including systemic sclerosis and dermatomyositis; however, studies on the prevalence and clinical characteristics of pruritus in CLE are limited. We have performed a multinational, prospective, cross-sectional study in order to assess the prevalence and intensity of pruritus in adult patients suffering from various subtypes of CLE. Read More

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http://dx.doi.org/10.1155/2018/3491798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083500PMC
January 2019
25 Reads

MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus.

J Invest Dermatol 2019 Jan 18;139(1):51-61. Epub 2018 Aug 18.

Department of Medicine, Systemic Autoimmune Diseases Unit, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.

Cutaneous lupus erythematosus is a common and disfiguring manifestation in systemic lupus erythematosus. Subacute cutaneous lupus erythematosus and discoid lupus erythematosus (DLE) are the most prevalent forms. Despite sharing histological similarities, clinically they differ in their course and prognosis, suggesting different pathogenesis. Read More

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http://dx.doi.org/10.1016/j.jid.2018.07.026DOI Listing
January 2019
5 Reads

CyclinD1 Is Useful to Differentiate Langerhans Cell Histiocytosis From Reactive Langerhans Cells.

Am J Dermatopathol 2018 Sep 17. Epub 2018 Sep 17.

Pediatric Oncology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder characterized by clonal proliferation of neoplastic Langerhans cells (LCs). LC proliferation can also be seen in different reactive dermatosis. CyclinD1 is a downstream marker of mitogen-activated protein (MAP) kinase pathway, which is often activated in LCH. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001250DOI Listing
September 2018
1.430 Impact Factor

Rapamycin for refractory discoid lupus erythematosus.

Dermatol Ther 2018 09 14;31(5):e12631. Epub 2018 Aug 14.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

Generalized discoid lupus erythematosus can pose a therapeutic challenge for dermatologists. Current treatment emphasizes photoprotection, topical and systemic steroids, and steroid-sparing immunosuppressive agents if necessary. Rapamycin, also known as sirolimus, selectively inhibits mammalian target of rapamycin, a regulatory kinase responsible for multiple signal transduction pathways. Read More

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http://dx.doi.org/10.1111/dth.12631DOI Listing
September 2018
3 Reads

Ocular Involvement in Systemic Lupus Erythematosus: The Experience of Two Tertiary Referral Centers.

Ocul Immunol Inflamm 2018 10;26(8):1154-1165. Epub 2018 Aug 10.

b Department of Biomedical Sciences and Human Oncology , University of Bari Medical School , Bari , Italy.

Purpose: To assess the prevalence of the ocular manifestations related to the disease and/or ascribable to the administration of potentially toxic drugs in a cohort of 98 patients with systemic lupus erythematosus (SLE).

Methods: Retrospective, observational study reporting the experience of two tertiary referral centers.

Results: Overall, an ocular involvement was detected in 29 patients (29. Read More

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http://dx.doi.org/10.1080/09273948.2018.1501495DOI Listing
December 2018
2 Reads

Damage accrual in systemic lupus erythematosus in Dominicans in New York City and the Dominican Republic.

Lupus 2018 Oct 9;27(12):1989-1995. Epub 2018 Aug 9.

1 Columbia University College of Physicians and Surgeons, New York, USA.

Objectives Hispanics with systemic lupus erythematosus (SLE) in the United States have more severe disease and damage accrual compared with whites. Data on Hispanics of similar ancestry in geographically different locations is limited but essential in defining genetic and environmental factors for SLE. This study evaluates SLE disease burden in two Dominican communities, Washington Heights in New York City (NYC) and Santiago in the Dominican Republic (DR). Read More

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http://dx.doi.org/10.1177/0961203318791764DOI Listing
October 2018
2 Reads

Coexistence of Tumid Lupus Erythematosus and Discoid Lupus Erythematosus.

Actas Dermosifiliogr 2018 Jul 30. Epub 2018 Jul 30.

Servicio de Dermatología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

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http://dx.doi.org/10.1016/j.ad.2018.02.023DOI Listing
July 2018
1 Read

Hardness and Painful Lesion of the Breast.

Acta Dermatovenerol Croat 2017 Dec;25(4):305-306

Alejandro Vilas Sueiro, MD, Department of Dermatology, Naval Hospital, University Hospital Complex of Ferrol, Avenida Residencia SN, 15405 Ferrol (A Coruña), Spain;

Dear Editor, Lupus panniculitis or lupus profundus is a rare inflammatory complication found in patients with systemic lupus erythematosus (SLE), or discoid lupus erythematosus (DLE) (1). When the breast is involved, the term lupus mastitis (LM) is used. This disease involving the breast is rare, and the lesions may precede, coincide with, or occur later than the onset of other lupus lesions. Read More

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December 2017
15 Reads

Atrophic and Annular Scarring Alopecia of the Scalp as a Finding in Underlying Systemic Sarcoidosis.

Acta Dermatovenerol Croat 2017 Dec;25(4):298-299

Dario Didona, MD, Prima Divisione Dermatologica , Istituto Dermopatico dell'Immacolata-IRCCS, Via dei Mont di Creta 104 , 00167 Rome, Italy;

Cutaneous sarcoidosis is not an uncommon disorder, and the skin can be the sole manifestation in about 10% of patients. However, when the involved anatomical area of the cutaneous sarcoidosis is the scalp and it presents as a scarring alopecia, there is an increased risk of a systemic disease (1,2). A 79-year-old Caucasian male patient presented to our Institute with annular and painless plaques of the scalp, with variable diameter, showing a reddish and yellowish color (Figure 1, a). Read More

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December 2017
15 Reads

Unilateral Discoid Lupus Erythematosus Over the Face: An Unusual Presentation.

Indian Dermatol Online J 2018 Jul-Aug;9(4):268-269

Department of Pathology, AIIMS, New Delhi, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_173_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042185PMC
July 2018
2 Reads

White and yellow dots as new trichoscopic signs of severe female androgenetic alopecia in dark skin phototypes.

Int J Dermatol 2018 Oct 25;57(10):1221-1228. Epub 2018 Jul 25.

Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, Egypt.

Background: Androgenetic alopecia or female pattern hair loss is the condition that most commonly leads to hair loss in adult females. The trichoscope is used for the early diagnosis of the disease. The study aims at finding a possible association between trichoscopic signs and disease severity in dark-skinned females. Read More

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http://dx.doi.org/10.1111/ijd.14140DOI Listing
October 2018
12 Reads

[Epidemiology of systemic lupus erythematosus in Reunion Island, Indian Ocean: A case-series in adult patients from a University Hospital].

Rev Med Interne 2018 Jul 21. Epub 2018 Jul 21.

Service de médecine interne, hôpital Félix-Guyon, CHU de La Réunion, allée des Topazes, CS 11021, 97400 Saint-Denis, Réunion. Electronic address:

Objectives: The study aimed at assessing the epidemiology and clinical features of systemic lupus erythematosus (SLE) in Reunion Island, South West of Indian Ocean.

Patients And Methods: A retrospective study was conducted at the University Hospital of La Reunion (Saint-Denis) by charts review from 2004 to 2015. Patients with a SLE diagnosed over 15 years according to SLICC 2012 criteria were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02488663183064
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http://dx.doi.org/10.1016/j.revmed.2018.07.004DOI Listing
July 2018
2 Reads

Ex vivo fluorescence confocal microscopy for intraoperative, real-time diagnosis of cutaneous inflammatory diseases: A preliminary study.

Exp Dermatol 2018 Oct 14;27(10):1152-1159. Epub 2018 Aug 14.

Department of Surgery, Medicine, Dentistry and Morphological Sciences with interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Ex vivo fluorescence confocal microscopy (FCM) is an innovative imaging tool that can be used intraoperatively to obtain real-time images of untreated excised tissue with almost histologic resolution. As inflammatory diseases often share overlapping clinical features, histopathology evaluation is required for dubious cases, delaying definitive diagnoses, and therefore therapy. This study identifies key-features at ex vivo FCM for differential diagnoses of cutaneous inflammatory diseases, in particular, psoriasis, eczema, lichen planus and discoid lupus erythematosus. Read More

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http://dx.doi.org/10.1111/exd.13754DOI Listing
October 2018
10 Reads
3.762 Impact Factor

Chronic Inflammation Promotes Skin Carcinogenesis in Cancer-Prone Discoid Lupus Erythematosus.

J Invest Dermatol 2019 Jan 17;139(1):62-70. Epub 2018 Jul 17.

Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

High-risk skin cancer is a rare, but severe, complication associated with discoid lupus erythematosus (DLE). Chronic scar, inflammation, UVR, and immunosuppressive medications are proposed explanations for this heightened skin cancer risk; however, the exact mechanism driving skin carcinogenesis in DLE is unknown. The distinct co-localization of multiple independent skin cancers with areas of active inflammation in two DLE patients followed over 8 years strongly suggested that lupus inflammation promotes skin carcinogenesis in DLE. Read More

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http://dx.doi.org/10.1016/j.jid.2018.06.185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309656PMC
January 2019
8 Reads

Mepacrine-induced interstitial lung disease in discoid lupus erythematosus?

Br J Dermatol 2018 Oct 23;179(4):1015. Epub 2018 Aug 23.

Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.

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http://doi.wiley.com/10.1111/bjd.17027
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http://dx.doi.org/10.1111/bjd.17027DOI Listing
October 2018
4 Reads

Treating lupus patients with antimalarials: analysis of safety profile in a single-center cohort.

Lupus 2018 Sep 28;27(10):1616-1623. Epub 2018 Jun 28.

Sapienza Università di Roma, Dipartimento di Medicina Interna e Specialità Mediche, Rome, Italy.

This longitudinal retrospective study aims at describing the safety profile and the reasons for discontinuation of antimalarials in patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE), focusing on ocular toxicity. We analyzed the clinical data of 845 SLE and DLE patients; 59% of them were taking antimalarials: 1.4% chloroquine (CQ), 88. Read More

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http://dx.doi.org/10.1177/0961203318781008DOI Listing
September 2018
13 Reads

The Coexistence of Systemic Lupus Erythematosus and Psoriasis: Is It Possible?

Acta Med Indones 2018 Apr;50(2):144-150

Department of Internal Medicine, Faculty of Medicine, Airlanggan University - dr. Soetomo Hospital, Surabaya, Indonesia.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with various clinical disorders and frequent exacerbations. Psoriasis vulgaris is a common skin disorder which affect 1-3% of general populations. The pathophysiology regarding the coexistence of these diseases is not fully understood. Read More

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April 2018
3 Reads

Hair and Scalp Changes in Cutaneous and Systemic Lupus Erythematosus.

Am J Clin Dermatol 2018 Oct;19(5):679-694

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.

Cutaneous and systemic lupus erythematosus (SLE) commonly involves the hair and scalp. Alopecia can result from direct activity of disease on the scalp or from the state of physical stress in the form of telogen effluvium. Discoid lupus erythematosus and lupus panniculitis/profundus are known to cause scarring alopecia, while accumulation of recent studies has shown that non-scarring alopecia in SLE may have different subtypes, comprising lupus erythematosus-specific and lupus erythematosus-nonspecific changes on histology. Read More

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http://dx.doi.org/10.1007/s40257-018-0363-8DOI Listing
October 2018
20 Reads