553 results match your criteria Lupus Erythematosus Bullous


Exosomes in chronic inflammatory skin diseases and skin tumors.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Exosomes are a type of endosome that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Read More

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http://dx.doi.org/10.1111/exd.13857DOI Listing
December 2018
1 Read

The incidence of herpes zoster in cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

Authors:
Eden Lake

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La, Grange Park, IL. Electronic address:

The incidence of zoster is increased in many autoimmune diseases. This study found a significantly increased zoster incidence in dermatomyositis and cutaneous lupus erythematosus compared with a control group.Physicians should be aware of this risk and consider administering the vaccine against zoster to these patients if not contraindicated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183297
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http://dx.doi.org/10.1016/j.jaad.2018.10.077DOI Listing
December 2018
7 Reads

Does Complement Have a Role in the Pathogenesis of Alopecia Areata?

Skin Appendage Disord 2018 Oct 22;4(4):261-263. Epub 2018 Mar 22.

Department of Dermatology, University of California, Irvine, Irvine, California, USA.

Alopecia areata (AA) is an autoimmune disorder in which immune attack of the anagen follicle causes hair loss in approximately 2% of the population. Although the pathogenesis of AA has not been fully determined, most likely it is mediated by a variety of factors including cellular/humoral immunity and genetic predisposition. Researchers have been interested in the possible role of the complement pathway in AA since the 1970s. Read More

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http://dx.doi.org/10.1159/000487448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219235PMC
October 2018
7 Reads

[When drugs induce cutaneous lupus erythematosus].

Ugeskr Laeger 2018 Oct;180(41)

Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is defined as an adverse reaction to continuous use of a culprit drug. The reaction resolves upon drug withdrawal. More than 50 drugs have been linked to DI-SCLE, and it is estimated, that around 20% of the SCLE cases are drug-induced. Read More

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October 2018
3 Reads

Scleredema of Buschke associated with lichen sclerosus: Three cases.

Indian J Dermatol Venereol Leprol 2018 Oct 4. Epub 2018 Oct 4.

"Mario Aresu" Department of Medical Science, Section of Dermatology, University of Cagliari, Cagliari, Italy.

Scleredema adultorum of Buschke is a rare fibromucinous, scleroderma-like connective tissue disease most commonly found in a post-infectious setting or linked to hematological disorders or diabetes. Lichen sclerosus et atrophicus is an autoimmune condition only in 2.5% of cases localized exclusively at an extragenital site, occurring in up to 34% of patients in association with other autoimmune diseases such as vitiligo, thyroid disorders, alopecia areata, lichen planus, morphea, pernicious anemia and systemic lupus erythematosus. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_288_17DOI Listing
October 2018
3 Reads

Bullous systemic lupus erythematosus associated with increased activity of lupus nephritis: a case report and review of the literature.

Postepy Dermatol Alergol 2018 Aug 21;35(4):431-433. Epub 2018 Aug 21.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.

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http://dx.doi.org/10.5114/ada.2018.77676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130133PMC
August 2018
1 Read

Autoimmune skin disease among dermatology outpatients in Botswana: a retrospective review.

Int J Dermatol 2019 Jan 31;58(1):50-53. Epub 2018 Aug 31.

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Background: There is a paucity of data describing autoimmune skin diseases in sub-Saharan Africa and in HIV positive cohorts. We describe the incidence of autoimmune skin diseases in public dermatology clinics in Botswana.

Methods: New patient records from public dermatology clinics were reviewed retrospectively for the period of September 2008 to December 2015. Read More

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http://dx.doi.org/10.1111/ijd.14201DOI Listing
January 2019
16 Reads
1.230 Impact Factor

Fogo selvagem: endemic pemphigus foliaceus.

An Bras Dermatol 2018 Sep-Oct;93(5):638-650

Dermatology Service, Hospital Maria Aparecida Pedrossian, Universidade Federal de Mato Grosso do Sul, Campo Grande (MS), Brazil.

Fogo selvagem or endemic pemphigus foliaceus is an autoimmune acantholytic anti-cadherin bullous disease that primarily affects seborrheic areas, which might disseminate. Brazil has the world's largest number of patients, mainly in the Central-West region, but the disease has also been reported in other South American countries. It affects young people and adults who have been exposed to rural areas, with occurrence of familial cases. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20188235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106655PMC
October 2018
10 Reads

Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus: report of a case and review of the literature.

Dermatol Online J 2018 05 15;24(5). Epub 2018 May 15.

Department of Dermatology, University of California San Diego, La Jolla, California.

Severe bullous eruptions in systemic lupus erythematosus (SLE) patients include bullous SLE, Rowell syndrome, toxic epidermal necrolysis (TEN), and TEN-like eruption of acute cutaneous lupus (TEN-like ACLE). TEN-like ACLE, a rare manifestation of SLE that closely mimics TEN, can be distinguished by characteristic clinical and laboratory findings. A 27-year-old man with SLE who developed TEN-like ACLE after initiating mycophenolate mofetil for active SLE is reported. Read More

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May 2018
9 Reads

The Value of Type IV Collagen Immunohistochemical Staining in the Differential Diagnosis of Autoimmune Subepidermal Bullous Diseases.

Acta Dermatovenerol Croat 2018 Jun;26(2):133-138

Hai-Jin Park, MD, Inje Univ. Ilsan Paik Hospital, 170 Juwha-Ro, Ilsanseo-gu, Goyang, Gyeonggi-do, Korea;

Autoimmune subepidermal bullous diseases (AISBDs) exhibit various clinical presentations, histological appearances, prognoses, and responses to treatment. Many diagnostic techniques, such as direct immunofluorescence (IF), indirect salt-split skin IF, and enzyme-linked immunosorbent assays, are used in the differential diagnoses of AISBDs. However, these techniques require fresh frozen tissue, expensive laboratory equipment, and sophisticated laboratory techniques. Read More

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June 2018
3 Reads

Bullous Pemphigoid Associated with Adalimumab Therapy in a Patient with Ulcerative Colitis.

Case Rep Dermatol 2018 May-Aug;10(2):145-148. Epub 2018 May 24.

Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany.

Bullous pemphigoid (BP) is a blistering autoimmune disease mainly observed in elderly patients. Several triggers are known for this autoimmune disease and some drugs are known to be a cause of BP. However, there are only few case reports on the induction of BP under adalimumab therapy. Read More

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http://dx.doi.org/10.1159/000489163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006603PMC
May 2018
1 Read

Clindamycin-induced Maculopapular Exanthema with Preferential Involvement of Striae Distensae: A Koebner phenomenon?

Acta Dermatovenerol Croat 2018 Apr;26(1):61-63

Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;

Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

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April 2018
14 Reads

Complement Activation in Inflammatory Skin Diseases.

Front Immunol 2018 16;9:639. Epub 2018 Apr 16.

Department of Pathology, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands.

The complement system is a fundamental part of the innate immune system, playing a crucial role in host defense against various pathogens, such as bacteria, viruses, and fungi. Activation of complement results in production of several molecules mediating chemotaxis, opsonization, and mast cell degranulation, which can contribute to the elimination of pathogenic organisms and inflammation. Furthermore, the complement system also has regulating properties in inflammatory and immune responses. Read More

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http://dx.doi.org/10.3389/fimmu.2018.00639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911619PMC
April 2018
3 Reads

Immunoglobulin E-Mediated Autoimmunity.

Front Immunol 2018 9;9:689. Epub 2018 Apr 9.

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

The study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, which may be termed autoallergy, is in its infancy. It is now recognized that systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, both spontaneous and inducible, are most likely to be mediated, at least in part, by IgE autoantibodies. The situation in other conditions, such as autoimmune uveitis, rheumatoid arthritis, hyperthyroid Graves' disease, autoimmune pancreatitis, and even asthma, is far less clear but evidence for autoallergy is accumulating. Read More

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http://dx.doi.org/10.3389/fimmu.2018.00689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900004PMC
April 2018
8 Reads

Leukocytoclastic Vasculitis Concurrent With Bullous Systemic Lupus Erythematosus Manifesting Striking Wood-Grain and Wi-Fi Sign-like Purpuric Lesions.

J Clin Rheumatol 2018 Apr 13. Epub 2018 Apr 13.

From the Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.1097/RHU.0000000000000717DOI Listing
April 2018
4 Reads

The devil's in the dosing: severe drug-induced liver injury in a hydroxychloroquine-naive patient with subacute cutaneous lupus erythematosus and porphyria cutanea tarda.

Lupus 2018 Jul 9;27(8):1383-1386. Epub 2018 Apr 9.

1 Division of Rheumatology, University of Michigan Medical School, USA.

A 29-year-old woman with a 1.5 year history of photosensitive skin lesions on her hands presented with a malar rash, bullous lesions on her hands, and was diagnosed with subacute lupus erythematosus after serologies revealed a positive antinuclear antibody test (1:2560), and antibodies to Ro/SSA and dsDNA. Hydroxychloroquine (400 mg/day) was prescribed and the patient developed severe drug-induced liver injury. Read More

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http://dx.doi.org/10.1177/0961203318768884DOI Listing
July 2018
4 Reads

Clinical image: bullous lupus erythematosus.

Rheumatology (Oxford) 2018 Sep;57(9):1601

Department of Medicine, Postgraduate Institute of Medical Education and Research, Dr Ram Manohar Lohia Hospital, New Delhi, India.

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http://dx.doi.org/10.1093/rheumatology/key084DOI Listing
September 2018
3 Reads

Scabies Surrepticius: Scabies Masquerading as Pityriasis Rosea.

Cureus 2017 Dec 19;9(12):e1961. Epub 2017 Dec 19.

Department of Dermatology, University of California, San Diego.

Scabies, a mite infestation caused by 'Sarcoptes scabiei', most commonly presents as pruritic linear burrows where the mite has invaded the skin. Scabies variant such as bullous, crusted, hidden, incognito, nodular and scalp-mimic the other conditions. In addition, atypical presentations of scabies can masquerade as dermatitis herpetiformis, ecchymosis, Langerhans cell histiocytosis, systemic lupus erythematosus, urticaria, and urticaria pigmentosa. Read More

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http://dx.doi.org/10.7759/cureus.1961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820012PMC
December 2017
5 Reads

Bullous systemic lupus erythematosus.

Presse Med 2018 Feb 23;47(2):190-191. Epub 2018 Feb 23.

Mohammed V Military-Teaching hospital, university Souissi, department of internal medicine, Rabat, Morocco.

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https://linkinghub.elsevier.com/retrieve/pii/S07554982173057
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http://dx.doi.org/10.1016/j.lpm.2017.11.021DOI Listing
February 2018
6 Reads

Bullous systemic lupus erythematosus in a 10-year-old child.

An Bras Dermatol 2017 ;92(5 Suppl 1):37-39

Dr. Günter Hans Department of Dermatology at Hospital Universitário Maria Aparecida Pedrossian, of the Universidade Federal de Mato Grosso do Sul (HUMAP-UFMS) - Campo Grande (MS), Brazil.

Bullous systemic lupus erythematosus (BSLE) is a rare autoimmune subepidermal blistering disease, with few cases described in childhood. It has different clinical-pathological features. We report a case of BSLE in a 10-year-old child with systemic lupus erythematosus, treated with prednisone and hydroxychloroquine. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/abd1806-4841.20176074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726672PMC
March 2018
11 Reads

Bullous Pemphigoid Masquerading as Erythema Annulare Centrifugum.

Acta Dermatovenerol Croat 2017 Oct;25(3):255-256

Sheng-Yiao Lin, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan;

Dear Editor, Bullous pemphigoid (BP), a relatively common autoimmune blistering disease in the elderly, is characterized by large, tense bullae on urticarial, erythematous, or normal skin. However, atypical BP with polymorphic clinical presentations is rarely encountered, leading to misdiagnosis and delayed treatments (1). BP with lesions resembling erythema gyratum repens or figurate erythema has been regarded as a paraneoplastic phenomenon (1). Read More

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October 2017
18 Reads

High-dose intravenous immunoglobulins for the treatment of dermatological autoimmune diseases.

J Dtsch Dermatol Ges 2017 Dec;15(12):1211-1226

Department of Dermatology, University of Heidelberg, Heidelberg, Germany.

Based on their immunomodulatory properties, high-dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second- or third-line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second-line therapy after failure of corticosteroid monotherapy. Read More

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http://dx.doi.org/10.1111/ddg.13389DOI Listing
December 2017
17 Reads

Oral Manifestation in Patients diagnosed with Dermatological Diseases.

J Contemp Dent Pract 2017 Dec 1;18(12):1153-1158. Epub 2017 Dec 1.

Department of Oral Pathology and Microbiology, M. A. Rangoonwala College of Dental Sciences & Research Centre Pune, Maharashtra, India.

Aim: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India.

Materials And Methods: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014. A total of 310 patients (mean age 37. Read More

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December 2017
5 Reads

Clinical, histological, immunological presentations and outcomes of bullous systemic lupus erythematosus: 10 New cases and a literature review of 118 cases.

Semin Arthritis Rheum 2018 08 4;48(1):83-89. Epub 2017 Nov 4.

AP-HP, Service de Médecine Interne 2, Centre National de Référence des Maladies Systémiques Rares, Lupus et Syndrome des Anticorps antiphospholipides, Institut e3m, Groupe Hospitalier Pitié-Salpêtrière, Paris 75013, France; Université Paris VI Pierre et Marie Curie, Sorbonnes Universités, Paris 75013, France.

Background: Bullous systemic lupus erythematosus (BSLE) is a rare blistering condition associated with systemic lupus erythematosus (SLE).

Patients And Methods: We conducted a multi-center retrospective study and literature review in order to describe the clinical, immunological, and histological presentations and outcomes of BSLE. The skin biopsies were centrally reviewed, and sera obtained during a flare of BSLE were analyzed for identification of circulating anti-basement membrane zone antibodies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172173030
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http://dx.doi.org/10.1016/j.semarthrit.2017.11.003DOI Listing
August 2018
24 Reads
3.920 Impact Factor

International Bullous Diseases Group: consensus on diagnostic criteria for epidermolysis bullosa acquisita.

Br J Dermatol 2018 Jul 8;179(1):30-41. Epub 2018 May 8.

Department of Dermatology at St George Hospital, University of New South Wales, Sydney, Australia.

Background: Epidermolysis bullosa acquisita (EBA) is a complex autoimmune bullous disease disease with variable clinical presentations and multiple possible diagnostic tests, making an international consensus on the diagnosis of EBA essential.

Objectives: To obtain an international consensus on the clinical and diagnostic criteria for EBA.

Methods: The International Bullous Diseases Group (IBDG) met three times to discuss the clinical and diagnostic criteria for EBA. Read More

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http://dx.doi.org/10.1111/bjd.16138DOI Listing
July 2018
2 Reads

Spectrum of orocutaneous disease associations: Immune-mediated conditions.

J Am Acad Dermatol 2017 Nov;77(5):795-806

Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:

There are a number of diseases that manifest both on the skin and the oral mucosa, and therefore the importance for dermatologists in clinical practice to be aware of these associations is paramount. In the following continuing medical education series, we outline orocutaneous disease associations with both immunologic and inflammatory etiologies. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.02.019DOI Listing
November 2017
12 Reads

Lupus-like cutaneous reaction following pembrolizumab: An immune-related adverse event associated with anti-PD-1 therapy.

J Cutan Pathol 2018 Jan 10;45(1):74-77. Epub 2017 Nov 10.

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

PD-1 (programmed cell death-1) inhibitors, used to treat metastatic melanoma and other malignancies, are associated with development of immune-related adverse events in the skin. Such reactions include morbilliform eruptions, vitiligo, alopecia areata and bullous pemphigoid. In this report, we describe a patient who developed a lupus-like cutaneous reaction in the setting of pembrolizumab therapy for metastatic melanoma, adding to the spectrum of reactions which may be observed in association with PD-1 inhibitor therapy. Read More

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http://dx.doi.org/10.1111/cup.13059DOI Listing
January 2018
4 Reads

Bullous systemic lupus erythematosus in a 6-year-old boy.

Pediatr Dermatol 2017 Nov 29;34(6):e313-e316. Epub 2017 Aug 29.

Department of Dermatology, School of Medicine, Yale University, New Haven, CT, USA.

Bullous systemic lupus erythematosus (BSLE) is a rare subepidermal blistering disorder characterized by an acute vesiculobullous eruption in a subset of individuals with systemic lupus erythematosus. BSLE most commonly affects young women and only rarely affects children. Herein we report a rare case of BSLE in a 6-year-old boy. Read More

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http://dx.doi.org/10.1111/pde.13258DOI Listing
November 2017
6 Reads

The Value of Direct Immunofluorescence on Proteinase-Digested Formalin-Fixed Paraffin-Embedded Skin Biopsies.

Am J Dermatopathol 2018 Feb;40(2):111-117

Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

Direct immunofluorescence (DIF) on frozen tissue (DIF-F) is the method of choice for the identification of immune deposits present in skin and other tissues. DIF can also be performed on formalin-fixed paraffin-embedded tissue (DIF-P) after antigen retrieval with proteases and has proven to be of value in renal pathology. However, its utility in skin biopsies has not been fully examined. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000934DOI Listing
February 2018
18 Reads

Persistent lip enlargement: An unusual presentation of lupus erythematosus.

Int J Womens Dermatol 2017 Jun 22;3(2):96-99. Epub 2016 Dec 22.

Autoimmune Bullous Diseases Research Center, Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.

Macrocheilia is a challenging problem with a variety of underlying causes that are both local and systemic, and granulomatous causes underlie the majority of cases. In this study, we report on a 31-year old man who presented with a chronic lower lip enlargement and a nodular submental erythematous lesion. He was otherwise clinically healthy. Read More

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http://dx.doi.org/10.1016/j.ijwd.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440449PMC
June 2017
1 Read

Unusual presentation of systemic lupus erythematosus.

Saudi J Kidney Dis Transpl 2017 May-Jun;28(3):653-656

Department of Nephrology, M. S. Ramaiah Memorial Hospital, Bengaluru, Karnataka, India.

Bullous systemic lupus erythematosus is a rare distinctive subepidermal blistering disorder that can occur in patients with systemic lupus erythematosus (SLE). It is histologically characterized by a neutrophil-predominant infiltrate in the subepidermal region with deposition of immunoglobulins (IgG, IgA, IgM), C3, and auto-antibodies against collagen VII. Herein, we report a case of a 13-year-old girl who presented with bullous SLE and Class III lupus nephritis, which is extremely rare at this age. Read More

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http://dx.doi.org/10.4103/1319-2442.206468DOI Listing
May 2017
12 Reads

Evaluation of prolactin levels in patients with newly diagnosed pemphigus vulgaris and its correlation with pemphigus disease area index.

Int J Womens Dermatol 2016 Jun 23;2(2):53-55. Epub 2016 Apr 23.

Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.

Background: Prolactin is a hormone; in addition to it known roles, it has immunomodulatory effects on lymphocytes maturation and immunoglobulins production. Hyperprolactinemia has been demonstrated in various autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes mellitus, and Graves' disease. In view of the prolactin immunomodulatory roles, studying prolactin levels in pemphigus as an autoimmune blistering disease may introduce new ways of understanding disease etiology and developing treatment strategies. Read More

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http://dx.doi.org/10.1016/j.ijwd.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412104PMC
June 2016
23 Reads

[Thymoma and autoimmune diseases].

Rev Med Interne 2018 Jan 30;39(1):17-26. Epub 2017 Mar 30.

Service de médecine interne, hospices civils de Lyon, hôpital de la Croix-Rousse, université Claude-Bernard - Lyon 1, 103, grande rue de la Croix-Rousse, 69004 Lyon, France.

The association between thymoma and autoimmunity is well known. Besides myasthenia gravis, which is found in 15 to 20% of patients with thymoma, other autoimmune diseases have been reported: erythroblastopenia, systemic lupus erythematosus, inflammatory myopathies, thyroid disorders, Isaac's syndrome or Good's syndrome. More anecdotally, Morvan's syndrome, limbic encephalitis, other autoimmune cytopenias, autoimmune hepatitis, and bullous skin diseases (pemphigus, lichen) have been reported. Read More

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http://dx.doi.org/10.1016/j.revmed.2017.03.003DOI Listing
January 2018
1 Read

A 12-year retrospective review of bullous systemic lupus erythematosus in cutaneous and systemic lupus erythematosus patients.

Lupus 2017 Oct 30;26(12):1278-1284. Epub 2017 Mar 30.

Division of Dermatology, Department of Internal Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Objective The aim of this study was to investigate the clinical features, laboratory findings, systemic manifestations, treatment and outcome of patients with bullous systemic lupus erythematosus in a tertiary care center in Thailand. Methods We performed a retrospective review from 2002 to 2014 of all patients who fulfilled the diagnostic criteria for bullous systemic lupus erythematosus to evaluate for the clinical characteristics, extracutaneous involvement, histopathologic features, immunofluorescence pattern, serological abnormalities, internal organ involvement, treatments and outcome. Results Among 5149 patients with cutaneous lupus erythematosus and/or systemic lupus erythematosus, 15 developed vesiculobullous lesions. Read More

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http://dx.doi.org/10.1177/0961203317699714DOI Listing
October 2017
6 Reads

Systemic Lupus Erythematosus and Bullous Pemphigoid with Dramatic Response to Dapsone.

Am J Case Rep 2017 03 29;18:317-319. Epub 2017 Mar 29.

NEUROFARBA Department, University of Florence and AOU Meyer, Florence, Italy.

BACKGROUND Bullous pemphigoid is an autoimmune blistering disease, with relapses, isolated or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Joint manifestations rapidly respond to small or moderate doses of corticosteroids, whereas skin manifestations usually respond to antimalarial drugs. CASE REPORT We describe the clinical case of an 11-year-old girl with SLE. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383011PMC
March 2017
3 Reads

TWEAK/Fn14 Activation Contributes to the Pathogenesis of Bullous Pemphigoid.

J Invest Dermatol 2017 07 27;137(7):1512-1522. Epub 2017 Mar 27.

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China. Electronic address:

TWEAK participates in various cellular effects by engaging its receptor of Fn14. Increased levels of soluble TWEAK are associated with systemic autoimmunity in patients with lupus erythematosus, rheumatoid arthritis, or dermatomyositis. However, the role of TWEAK in bullous pemphigoid (BP) remains unknown. Read More

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http://dx.doi.org/10.1016/j.jid.2017.03.019DOI Listing
July 2017
9 Reads

Reply to: Direct Immunofluorescence Findings in Discoid Lupus Erythematosus and Bullous Pemphigoid.

Am J Dermatopathol 2017 04;39(4):321-322

Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.

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http://dx.doi.org/10.1097/DAD.0000000000000650DOI Listing
April 2017
2 Reads

Common Skin Conditions in Children: Noninfectious Rashes.

FP Essent 2017 Feb;453:18-25

University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.

Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

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February 2017
39 Reads

Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses.

Autoimmunity 2017 Feb;50(1):25-36

a Department of Respiratory , Inflammation & Autoimmunity, MedImmune LLC , Gaithersburg , MD , USA.

Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their role in allergies, IgE autoantibodies are not associated with a higher rate of atopy in these patients. Read More

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http://dx.doi.org/10.1080/08916934.2017.1280670DOI Listing
February 2017
18 Reads

Bullous Systemic Lupus Erythematosus and Lupus Nephritis in a Young Girl.

Oman Med J 2016 Nov;31(6):453-455

Division of Pediatric Nephrology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences Isfahan, Iran.

Bullous systemic lupus erythematosus (BSLE) is an autoimmune blistering disease occurring in patients with systemic lupus erythematosus (SLE). It is a rare disease, especially in children. A 14-year-old girl initially presented with fatigue, generalized vesiculobullous skin lesions, and ulcers over the hard palate and oral mucosa. Read More

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http://dx.doi.org/10.5001/omj.2016.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099405PMC
November 2016
2 Reads

Diffuse Bullous Eruptions in an Elderly Woman: Late-Onset Bullous Systemic Lupus Erythematosus.

Case Rep Dermatol 2016 Sep-Dec;8(3):278-282. Epub 2016 Oct 13.

Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, Ill., USA.

Vesiculobullous eruptions in the elderly represent a diverse range of varying pathophysiologies and can present a significant clinical dilemma to the diagnostician. Diagnosis requires a careful review of clinical history, attention to detail on physical and histomorphological examination, and appropriate immunofluorescence testing. We describe the case of a 73-year-old female who presented to our hospital with a painful blistering skin rash developed over 2 days. Read More

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http://dx.doi.org/10.1159/000448392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121548PMC
October 2016
17 Reads

[Systemic lupus erythematosus : Unusual cutaneous manifestations].

Hautarzt 2016 Dec;67(12):970-981

Abteilung Dermatologie und Venerologie, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Wien, Österreich.

Background: Various different mucocutaneous symptoms may affect up to 80 % of systemic lupus erythematosus (SLE) patients.

Objectives: To investigate, various unspecific, but otherwise typical clinical symptoms of skin and mucous membranes that arise in SLE patients other than those defined as SLE criteria such as butterfly rash, chronic cutaneous lupus erythematosus, oral ulcers, and increased photosensitivity.

Materials And Methods: Extensive search of peer-reviewed scientific articles was performed, medical histories of several SLE patients seen in our department were analyzed, and the rare disease courses in three SLE patients are presented. Read More

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http://dx.doi.org/10.1007/s00105-016-3893-0DOI Listing
December 2016
8 Reads

Lenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus.

Lupus 2017 May 12;26(6):646-649. Epub 2016 Nov 12.

2 Department of Pediatrics, Duke University Medical Center, Durham, USA.

Objective Cutaneous manifestations of pediatric systemic lupus erythematosus cause significant morbidity. Lenalidomide, a thalidomide analogue, has shown promise treating cutaneous lupus erythematosus in adults. Our objective was to evaluate lenalidomide's efficacy and safety in treating refractory cutaneous manifestations of pediatric systemic lupus erythematosus. Read More

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http://dx.doi.org/10.1177/0961203316676377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388573PMC
May 2017
9 Reads

Case of Pediatric Bullous Systemic Lupus Erythematosus Treated with Intravenous Immunoglobulin.

Pediatr Dermatol 2017 Jan 25;34(1):e54-e56. Epub 2016 Oct 25.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.

This is a case report of a 16-year-old girl recently diagnosed with systemic lupus erythematosus (SLE) who presented with multiple blisters on the face, hands, arms, legs, trunk, and vaginal and oral mucosa. Skin biopsy was consistent with bullous SLE (BSLE). Dapsone is often the first-line treatment option for BSLE, but the patient's history of anemia and leukopenia and long-term immunosuppression requirement for her systemic symptoms raised concerns about dapsone and bone marrow toxicity, especially hemolytic anemia and agranulocytosis. Read More

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http://dx.doi.org/10.1111/pde.13015DOI Listing
January 2017
3 Reads

A Case of Linear IgA Bullous Dermatosis Associated with Systemic Lupus Erythematosus.

Ann Dermatol 2016 Oct 30;28(5):660-662. Epub 2016 Sep 30.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

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http://dx.doi.org/10.5021/ad.2016.28.5.660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064206PMC
October 2016
5 Reads

Decreased PD-1 positive blood follicular helper T cells in patients with psoriasis.

Arch Dermatol Res 2016 Oct 8;308(8):593-9. Epub 2016 Aug 8.

Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, 50-1 Yonsei-Ro, Seodaemun-gu, Seoul, 120-752, Korea.

Follicular helper T (Tfh) cells are recently characterized subset of helper T cells, which are initially found in the germinal centers of B cell follicles. The major role of Tfh cells is helping B cell activation and antibody production during humoral immunity. Recently, blood Tfh cells were shown to be associated with autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, bullous pemphigoid and psoriasis. Read More

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http://dx.doi.org/10.1007/s00403-016-1679-yDOI Listing
October 2016
7 Reads

[Terbinafine : Drug-induced lupus erythematodes and triggering of psoriatic skin lesions].

Authors:
P Mayser

Hautarzt 2016 Sep;67(9):724-31

, Hofmannstr. 11, 35444, Biebertal, Deutschland.

Based on the technical information that oral terbinafine must be used with caution in patients with pre-existing psoriasis or lupus erythematosus, the literature was summarized. Terbinafine belongs to the drugs able to induce subcutaneous lupus erythematosus (SCLE)-with a relatively high risk. The clinical picture of terbinafine-induced SCLE may be highly variable and can also include erythema exsudativum multiforme-like or bullous lesions. Read More

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http://dx.doi.org/10.1007/s00105-016-3844-9DOI Listing
September 2016
2 Reads

The incidence of herpes zoster in cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

J Am Acad Dermatol 2016 Jul;75(1):42-8

Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: Herpes zoster is a common condition that causes significant morbidity.

Objective: This study determined the incidence of zoster in patients with cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

Methods: In this retrospective cohort study the electronic medical records of 186 patients with CLE, 103 with DM, 83 with PV, 44 with BP, and 152 healthy control patients were reviewed to confirm positive diagnoses of zoster. Read More

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http://dx.doi.org/10.1016/j.jaad.2016.02.1153DOI Listing
July 2016
13 Reads

Role of IgE in autoimmunity.

J Allergy Clin Immunol 2016 06 27;137(6):1651-1661. Epub 2016 Apr 27.

Respiratory, Inflammation & Autoimmunity Department, Research, MedImmune, Gaithersburg, Md.

There is accumulating evidence to suggest that IgE plays a significant role in autoimmunity. The presence of circulating self-reactive IgE in patients with autoimmune disorders has been long known but, at the same time, largely understudied. However, studies have shown that the increased IgE concentration is not associated with higher prevalence for atopy and allergy in patients with autoimmune diseases, such as systemic lupus erythematosus. Read More

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http://dx.doi.org/10.1016/j.jaci.2016.04.007DOI Listing
June 2016
7 Reads