Search our Database of Scientific Publications and Authors

I’m looking for a

    4135 results match your criteria Lupus Erythematosus Acute

    1 OF 83

    Thrombotic thrombocytopenic purpura in the course of systemic lupus erythematosus in a 15-year-old girl.
    Cent Eur J Immunol 2017 30;42(4):407-408. Epub 2017 Dec 30.
    Department of Pediatrics and Nephrology, Medical University of Warsaw, Poland.
    Systemic lupus erythematosus (SLE) concomitant with thrombotic thrombocytopenic purpura (TTP) in children is rarely diagnosed. We report a case of a 15-year-old girl with butterfly patch, generalized edema, leg pain, anemia (Hb 74 g/l), thrombocytopenia (5 x 10/l), schistocytes in peripheral blood smear, acute kidney injury (eGFR 27 ml/min/1.73 m), proteinuria, and erythrocyturia. Read More

    Unique urticarial presentation of minocycline-induced lupus erythematosus.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Department of Dermatology, University of California, Davis, Sacramento, CA USA, Department of Biological Sciences, California State Univeristy, Sacramento, CA USA.
    The association between guttate psoriasis and infection with group A Streptococcus (GAS) has been well established in the medical literature. However, responses to treatments aimed at GAS eradication such as systemic antibiotics or tonsillectomy are inconsistent. Further complicating treatment recommendations for a disease with a suspected microbial trigger, the standard therapy for severe psoriasis is with systemic immunosuppressant medications. Read More

    Haemolytic-uremic syndrome due to infection with adenovirus: A case report and literature review.
    Medicine (Baltimore) 2018 Feb;97(7):e9895
    Lucian Blaga University of Sibiu, Faculty of Medicine Sibiu, Romania.
    Rationale: Haemolytic-uremic syndrome is a rare but serious complication of bacterial and viral infections, which is characterized by the triad of: acute renal failure, microangiopathic haemolytic anemia and thrombocytopenia, sometimes severe, requiring peritoneal dialysis. In Europe, hemolytic-uremic syndrome (HUS) in paediatric pathology is primarily caused by Shiga toxin-producing Escherichia coli (STEC) O157, followed by O26. Beside these etiologies, there are other bacterial and viral infections, and also noninfectious ones that have been associated to lead to HUS as well: in the progression of neoplasia, medication-related, post-transplantation, during pregnancy or associated with the antiphospholipid syndrome, systemic lupus erythematosus or family causes with autosomal dominant or recessive inheritance. Read More

    Drug-induced Rowell syndrome, a rare and difficult to manage disease: A case report.
    Exp Ther Med 2018 Jan 23;15(1):785-788. Epub 2017 Nov 23.
    Department of Ophthalmology, Grigore T. Popa University of Medicine and Pharmacy, 700715 Iași, Romania.
    Rowell syndrome is defined as the association between lupus erythematosus, erythema multiforme-like lesions and characteristic immunological changes including positive tests for rheumatoid factor, speckled antinuclear antibody, positive anti-Ro or anti-La antibodies. The present report presents the case of a 45-year-old female patient who was previously diagnosed in January 2010 with terbinafine-induced subacute cutaneous lupus erythematosus and was admitted for a skin eruption consisting of erythematous-papular erythema multiforme-like lesions, primarily on the trunk and limbs. The associated symptoms consisted of fatigability, myalgia and gonalgia. Read More

    Bioactive Lipids and Chronic Inflammation: Managing the Fire Within.
    Front Immunol 2018 29;9:38. Epub 2018 Jan 29.
    Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
    Inflammation is an immune response that works as a contained fire that is pre-emptively sparked as a defensive process during infections or upon any kind of tissue insult, and that is spontaneously extinguished after elimination or termination of the damage. However, persistent and uncontrolled immune reactions act as a wildfire that promote chronic inflammation, unresolved tissue damage and, eventually, chronic diseases. A wide network of soluble mediators, among which endogenous bioactive lipids, governs all immune processes. Read More

    Ten-year retrospective clinicohistological study of cutaneous lupus erythematosus in Korea.
    J Dermatol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Dermatology, College of Medicine, University of Hanyang, Seoul, Korea.
    An understanding of the differences in clinical manifestations and laboratory abnormalities between subtypes of cutaneous lupus erythematosus (CLE) is still lacking. The purpose of this study was to analyze demographic, clinical and histological features of CLE according to three main presentation subsets: acute (ACLE), subacute (SCLE) and chronic (CCLE). A 10-year retrospective analysis was performed on data from patients who were diagnosed with CLE between March 2005 and September 2015 in a Korean tertiary referral dermatology clinic. Read More

    Causes and predictors of mortality in biopsy-proven lupus nephritis: the Sarawak experience.
    Clin Kidney J 2018 Feb 17;11(1):56-61. Epub 2017 Jul 17.
    Nephrology Unit, Department of Medicine, Sarawak General Hospital, Sarawak, Malaysia.
    Background: Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus that can be fatal if left untreated. The causes and prognostic predictors of mortality in LN have been well studied in developed countries but evidence is lacking for developing countries. The objective of this study was to investigate the causes and predictors of mortality in a cohort of Malaysian patients with biopsy-proven LN. Read More

    Gastrointestinal Manifestations of Autoimmune Diseases Requiring Critical Care.
    Crit Care Nurs Clin North Am 2018 Mar 6;30(1):1-12. Epub 2017 Dec 6.
    Capstone College of Nursing, The University of Alabama, Box 870358, Tuscaloosa, AL 35487, USA; Sacred Heart of Pensacola, Pensacola, FL, USA. Electronic address:
    Proper functioning within the gastrointestinal (GI) system is essential to immune integrity. Autoimmune diseases (ADs) can disrupt GI integrity and cause serious derangements of organ function. ADs exist on a continuum of mild to severe. Read More

    Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report.
    Medicine (Baltimore) 2018 Feb;97(5):e9794
    Division of Rheumatology/Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital.
    Rationale: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, spiking fever, arthralgia/ arthritis, and lymphadenopathy. AOSD sometimes was fatal when it is complicated by macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH). Nonetheless, the literature provides no recommendations for treatment of AOSD patients with severe sepsis. Read More

    Evaluation and Management of Spinal Subarachnoid Hemorrhage in a Patient with Lupus Vasculitis.
    Am J Case Rep 2018 Jan 31;19:114-117. Epub 2018 Jan 31.
    Department of Neurology, Advocate Christ Medical Center, Oak Lawn, IL, USA.
    BACKGROUND Isolated spinal artery subarachnoid hemorrhage is a rare occurrence in the general population, but occurs more commonly as one of many neurologic sequela of systemic lupus erythematosus (SLE). The etiology of a neurologic deficit in an SLE patient is often multifactorial. Comorbid conditions, such as antiphospholipid antibody syndrome, predispose to stroke. Read More

    Cutaneous lupus erythematosus: clinico-pathologic correlation.
    G Ital Dermatol Venereol 2018 Jan 24. Epub 2018 Jan 24.
    Dermatology Unit, "A. Perrino" Hospital, Brindisi, Italy.
    Cutaneous lupus erythematosus (CLE) is a chronic-relapsing disease. It is defined as a LE localized to the skin without any significant systemic symptoms. Its annual incidence is of 4 cases per 100,000 persons with a prevalence of 73 cases per 100,000 persons. Read More

    Performance of the 2012 Systemic Lupus International Collaborating Clinics classification criteria versus the 1997 American College of Rheumatology classification criteria in adult and juvenile systemic lupus erythematosus. A systematic review and meta-analysis.
    Autoimmun Rev 2018 Jan 31. Epub 2018 Jan 31.
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; 1st Medical Department & Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Hanusch Hospital, Vienna, Austria; Sigmund Freud University, Vienna, Austria. Electronic address:
    Objective: To evaluate the performance in classifying systemic lupus erythematosus by the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC'12), versus the revised American College of Rheumatology criteria from 1997 (ACR'97) in adult and juvenile SLE patients.

    Methods: A systematic literature search was conducted in PubMed and Embase for studies comparing SLICC'12 and ACR'97 with clinical diagnosis. A meta-analysis was performed to estimate the sensitivity and specificity of SLICC'12 and ACR'97. Read More

    [Renal Involvement in Connective Tissue Diseases].
    Dtsch Med Wochenschr 2018 Jan 22;143(2):89-100. Epub 2018 Jan 22.
    Renal involvement is common and heterogenous in connective tissue diseases and has a main influence on prognosis and mortality. In systemic lupus erythematosus proliferative glomerulonephritis is the most common manifestation, while in primary Sjogren's syndrome interstitial nephritis with tubular dysfunction is the predominant pathological feature. In systemic sclerosis the most serious renal manifestation is scleroderma renal crisis characterized by abrupt onset of hypertension and acute kidney injury associated with an increase in plasma renin activity. Read More

    ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus.
    J Bras Nefrol 2017 Oct-Dec;39(4):454-457
    Laboratorios Integrados S.A, Lima, Perú.
    The pauci-immune crescentic glomerulonephritis (PICGN) is generally associated with small-vessel vasculitis with a few reported cases associated with other autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We present the case of a female 34-year-old patient with acute kidney injury symptoms with indication for renal replacement therapy in the context of clinical SLE diagnosis. A kidney biopsy was conducted and it was found that most glomeruli showed some segmental sclerosis with synechia to the Bowman's capsule. Read More

    Proliferative lupus nephritis in the absence of overt systemic lupus erythematosus: A historical study of 12 adult patients.
    Medicine (Baltimore) 2017 Dec;96(48):e9017
    Service de néphrologie, CHU Bichat, AP-HP, INSERM U1199, Paris Diderot University and DHU FIRE, Paris, France.
    Severe lupus nephritis in the absence of systemic lupus erythematosus (SLE) is a rare condition with an unclear clinical presentation and outcome.We conducted a historical observational study of 12 adult (age >18 years) patients with biopsy-proven severe lupus nephritis or lupus-like nephritis without SLE immunological markers at diagnosis or during follow-up. Excluded were patients with chronic infections with HIV or hepatitis B or C; patients with a bacterial infectious disease; and patients with pure membranous nephropathy. Read More

    Vertebrobasilar Artery Stroke as the Heralding Sign of Systemic Lupus Erythematosus.
    J Stroke Cerebrovasc Dis 2018 Jan 3. Epub 2018 Jan 3.
    Department of Anesthesiology, SUNY-Buffalo, Buffalo, New York. Electronic address:
    Cerebral ischemia because of vertebrobasilar insufficiency (VBI) rarely presents as an initial sign within the systemic lupus erythematosus (SLE) population, and there are very few case reports supporting this manifestation. This report details 3 different patients with SLE who experienced VBI as an initial manifestation. Patient 1 was a 24-year-old female who developed a bilateral pontine lesion as a consequence of basilar artery stenosis. Read More

    Colonic perforation due to severe cytomegalovirus disease in granulomatosis with polyangiitis after immunosuppression.
    Clin Rheumatol 2018 Jan 4. Epub 2018 Jan 4.
    Rheumatology Unit, Department of Internal Medicine, Arcispedale Santa Maria Nuova, Azienda USL di Reggio Emilia - IRCCS, Viale Risorgimento 80, 42122, Reggio Emilia, Italy.
    Granulomatosis with polyangiitis (GPA) is a small-vessel necrotizing granulomatous vasculitis typically involving upper airways, lungs, and kidneys, which may lead to end-organ damage and life-threatening complications. Major infections during GPA course represent a considerable concern in the management of the disease. Cytomegalovirus (CMV) infection and disease are rare but significant complications in the course of GPA being associated with high morbidity and mortality rates. Read More

    Clinical features and prognoses of acute transverse myelitis in patients with systemic lupus erythematosus.
    Korean J Intern Med 2018 Jan 5. Epub 2018 Jan 5.
    Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Background/aims: Acute transverse myelitis (ATM) is a severe complication of systemic lupus erythematosus (SLE). This study evaluated the clinical factors related to outcome in patients with SLE-associated ATM.

    Methods: The medical records of patients diagnosed with SLE-associated ATM between January 1995 and January 2015 were reviewed. Read More

    Differential serum cytokine profile in patients with systemic lupus erythematosus and posterior reversible encephalopathy syndrome.
    Clin Exp Immunol 2017 Dec 22. Epub 2017 Dec 22.
    Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
    Systemic lupus erythematosus (SLE) patients are susceptible to the development of posterior reversible encephalopathy syndrome (PRES). The main theory concerning the physiopathology of PRES suggests that there is brain-blood barrier damage, which is associated with endothelial dysfunction, and characterized by vasogenic oedema. However, current evidence regarding its physiopathogenic mechanisms is quite scant. Read More

    Lupus podocytopathy: a distinct entity of lupus nephritis.
    J Nephrol 2017 Dec 22. Epub 2017 Dec 22.
    National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, 210016, Jiangsu, China.
    Systemic lupus erythematosus (SLE) patients clinically presenting with nephrotic syndrome demonstrating minimal change disease (MCD), mesangial proliferation (MsP) or focal segmental glomerulosclerosis (FSGS), while on electronic microscopy, diffuse podocyte foot process effacement in absence of sub-epithelial or sub-endothelial deposition is the only morphological feature and now diagnosed as lupus podocytopathy. Lupus podocytopathy with glomerular morphology of MCD or MsP usually presents with typical nephrotic syndrome and sensitive to glucocorticoid treatment, but the relapse rate could reach up to 90% on maintenance treatment with glucocorticoid alone. Glucocorticoid plus other immunosuppressive agents could significantly decrease the relapse rate. Read More

    T cell subsets and immunoglobulin G levels are associated with the infection status of systemic lupus erythematosus patients.
    Braz J Med Biol Res 2017 Dec 11;51(2):e4547. Epub 2017 Dec 11.
    Department of Rheumatology, Tianjin Medical University General Hospital, Tianjin, China.
    Systemic lupus erythematosus (SLE) is a chronic, autoimmune disorder that affects nearly all organs and tissues. As knowledge about the mechanism of SLE has increased, some immunosuppressive agents have become routinely used in clinical care, and infections have become one of the direct causes of mortality in SLE patients. To identify the risk factors indicative of infection in SLE patients, a case control study of our hospital's medical records between 2011 and 2013 was performed. Read More

    Efficacy of Rituximab in a Systemic Lupus Erythematosus Patient Presenting with Diffuse Alveolar Hemorrhage.
    Case Rep Rheumatol 2017 15;2017:6031053. Epub 2017 Nov 15.
    Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR, USA.
    Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of systemic lupus erythematosus (SLE). Although infrequent, its mortality is very high. While there are no established therapeutic guidelines, DAH has been traditionally managed with high-dose intravenous (IV) corticosteroids, cyclophosphamide, and plasma exchange. Read More

    Systemic lupus erythematosus and ocular involvement: an overview.
    Clin Exp Med 2017 Dec 14. Epub 2017 Dec 14.
    Department of Basic Medical Sciences, Neurosciences and Sensory Organ, University of Bari Medical School, Clinica Oculistica, Policlinico, Piazza Giulio Cesare, 70124, Bari, Italy.
    Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease of undefined etiology and with remarkably heterogeneous clinical features. Virtually any organ system can be affected, including the eye. SLE-related eye involvement can be diagnosed in approximately one-third of the patients and is usually indicative of disease activity. Read More

    Neuropsychiatric manifestations are not uncommon in Indian lupus patients and negatively affect quality of life.
    Lupus 2017 Jan 1:961203317747720. Epub 2017 Jan 1.
    1 Department of Internal Medicine, 29751 Postgraduate Institute of Medical Education and Research , Chandigarh, India.
    Objectives The objectives of this paper are to look at the prevalence of neuropsychiatric manifestations and assess their impact on quality of life in North Indian lupus patients. Methods The study included consecutive patients with systemic lupus erythematosus (SLE) who were older than 18 years and met the SLICC 2012 criteria. A diagnosis of a neuropsychiatric syndrome was made as per ACR 1999 definitions. Read More

    High-dose intravenous immunoglobulins for the treatment of dermatological autoimmune diseases.
    J Dtsch Dermatol Ges 2017 Dec;15(12):1211-1226
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
    Based on their immunomodulatory properties, high-dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second- or third-line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second-line therapy after failure of corticosteroid monotherapy. Read More

    Regulation of Neuroinflammation: What Role for the Tumor Necrosis Factor-Like Weak Inducer of Apoptosis/Fn14 Pathway?
    Front Immunol 2017 16;8:1534. Epub 2017 Nov 16.
    Aix-Marseille University, CNRS, NICN, Marseille, France.
    Observed in many central nervous system diseases, neuroinflammation (NI) proceeds from peripheral immune cell infiltration into the parenchyma, from cytokine secretion and from oxidative stress. Astrocytes and microglia also get activated and proliferate. NI manifestations and consequences depend on its context and on the acute or chronic aspect of the disease. Read More

    High Health Care Utilization Preceding Diagnosis of Systemic Lupus Erythematosus in Youth.
    Arthritis Care Res (Hoboken) 2017 Dec 1. Epub 2017 Dec 1.
    Center for Pediatric Clinical Effectiveness & PolicyLab, The Children's Hospital of Philadelphia.
    Objective: Childhood-onset systemic lupus erythematosus (SLE) is associated with high risk for organ damage, which may be mitigated by early diagnosis and treatment. We characterized health care utilization for youth in the year preceding SLE diagnosis compared to controls.

    Methods: Using ClinformaticsDataMart (OptumInsight, Eden Prairie, MN) de-identified administrative data from 2000 to 2013, we identified 682 youth ages 10-24 years with new-onset SLE (≥3 International Classification of Diseases, Ninth Revision (ICD-9) codes for SLE 710. Read More

    Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus.
    Sci Rep 2017 Nov 27;7(1):16428. Epub 2017 Nov 27.
    Laboratory of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka, 565-0871, Japan.
    The evolutional process of disease-associated autoantibodies in systemic lupus erythematosus (SLE) remains to be established. Here we show intraclonal diversification and affinity maturation of anti-nuclear antibody (ANA)-producing B cells in SLE. We identified a panel of monoclonal ANAs recognizing nuclear antigens, such as double-stranded DNA (dsDNA) and ribonucleoproteins (RNPs) from acute SLE subjects. Read More

    Illness representations of systemic lupus erythematosus and systemic sclerosis: a comparison of patients, their rheumatologists and their general practitioners.
    Lupus Sci Med 2017 14;4(1):e000232. Epub 2017 Nov 14.
    Department of Development and Regeneration, Katholieke Universiteit Leuven, Skeletal Biology and Engineering Research Center, Leuven, Belgium.
    Objective: Discrepancies in illness representations between patients and physicians result in treatment difficulties, decreased well-being of patients and misunderstandings and disrupted communication. Hence, the objective of this study was to compare illness perceptions of individual patients with systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), their rheumatologists and their general practitioners (GPs) and explore potential differences.

    Methods: This study has a cross-sectional design. Read More

    Effects of Arsenic Trioxide on INF-gamma Gene Expression in MRL/lpr Mice and Human Lupus.
    Biol Trace Elem Res 2017 Nov 20. Epub 2017 Nov 20.
    Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Nan Bai Xiang Street, Ouhai District, Wenzhou, Zhejiang Province, 325000, China.
    Arsenic trioxide (As2O3; ATO), a traditional Chinese medicine, is used to treat patients with acute promye-locytic leukemia, while its application for treatment of systemic lupus erythematosus (SLE) is still under evaluation. The high expression of INF-gamma (INF-γ) is a primary pathogenic factor in SLE. It is found that ATO can reduce INF-γ expression levels in lupus-prone mice, whereas it is not clear whether ATO has the same effect on SLE patients. Read More

    Renal Macrophages and Dendritic Cells in SLE Nephritis.
    Curr Rheumatol Rep 2017 Nov 9;19(12):81. Epub 2017 Nov 9.
    Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York, NY, 11030, USA.
    Purpose Of Review: The purpose of the study was to review the characteristics of renal macrophages and dendritic cells during homeostasis and disease, with a particular focus on lupus nephritis.

    Recent Findings: Resident renal macrophages derive from embryonic sources and are long-lived and self-renewing; they are also replaced from the bone marrow with age. The unique characteristics of macrophages in each tissue are imposed by the microenvironment and reinforced by epigenetic modifications. Read More

    Intravenous thrombolysis in SLE-related stroke: a case report and literature review.
    Neurol Sci 2018 Jan 7;39(1):155-159. Epub 2017 Nov 7.
    Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, Jiangsu Province, 210002, China.
    Patients with systemic lupus erythematosus (SLE) bear an increased risk of ischemic stroke. However, evidences for treating acute stroke due to artery thrombosis in SLE patients are extremely limited. A 45-year-old woman experienced sudden left hemiplegia. Read More

    Clinical features, outcome, and associated factors for posterior reversible encephalopathy in Thai patients with systemic lupus erythematosus: a case-control study.
    Clin Rheumatol 2017 Nov 4. Epub 2017 Nov 4.
    Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
    Posterior reversible encephalopathy syndrome (PRES) in patients with systemic lupus erythematosus (SLE) has been recognized increasingly. This study aimed to determine the prevalence, clinical features, brain imaging findings, outcomes, and associated factors of PRES in Thai SLE patients. SLE patients with PRES were identified from the lupus cohort of Chiang Mai University. Read More

    Cardiovascular disease in patients with autoinflammatory syndromes.
    Rheumatol Int 2018 Jan 1;38(1):37-50. Epub 2017 Nov 1.
    Academic Research Unit, 2nd Department of Internal Medicine, Kepler University Hospital, Med Campus III, Krankenhausstr. 9, 4020, Linz, Austria.
    Autoinflammatory syndromes (AIS) are characterized by recurring events of inflammation, leading to a variety of organ manifestations and fever attacks. A subgroup of AIS is commonly referred to as hereditary periodic fever syndromes (HPFS). There is substantial evidence that autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are strongly associated with cardiovascular morbidity and mortality. Read More

    The involvement of galectin-3 in skin injury in systemic lupus erythematosus patients.
    Lupus 2017 Jan 1:961203317736144. Epub 2017 Jan 1.
    1 Department of Dermatology, 56713 Sun Yat-sen Memorial Hospital , Guangzhou, China.
    Objective Our previous research suggested that anti-galectin-3 antibody was highly associated with the development of lupus skin lesions in systemic lupus erythematosus (SLE). In this study we aimed to investigate the involvement of galectin-3 in SLE skin damage. Methods The study consisted of 49 patients with SLE, 16 with dermatomyositis and 11 with systemic scleroderma and 20 healthy controls. Read More

    [Different Symptoms and Course of Coronary Heart Disease in Men and Women].
    Dtsch Med Wochenschr 2017 Oct 18;142(21):1578-1584. Epub 2017 Oct 18.
    According to the federal statistical office, cardiovascular disorders are still the leading cause of death in Germany. Chronic ischemic heart disease and acute myocardial infarction are the most important subgroups. In addition to evidence-based and personalized medicine, in recent years gender medicine has been established as an independent research area. Read More

    The multifactorial origin of posterior reversible encephalopathy syndrome in cyclophosphamide-treated lupus patients.
    Rheumatol Int 2017 Dec 17;37(12):2105-2114. Epub 2017 Oct 17.
    Department of Rheumatology and Clinical Immunology, Clinical Hospital Centre Rijeka, Krešimirova 42, 51000, Rijeka, Croatia.
    The cyclophosphamide as a predisposing factor for Posterior Reversible Encephalopathy Syndrome (PRES) and therapeutic option for systemic lupus erythematosus (SLE) is still confusing. The first and only case of PRES, probably induced by cyclophosphamide, in Croatia followed by the findings of 36 SLE patients diagnosed with PRES after treatment with cyclophosphamide worldwide are described. An 18-year-old Caucasian female patient with a 1-year history of SLE was admitted to the hospital due to lupus nephritis and acute arthritis. Read More

    Rheopheresis as a causal therapy option for systemic scleroderma (SSc).
    Clin Hemorheol Microcirc 2017 ;67(3-4):229-240
    Department of Dermatology, University Medicine Greifswald, Greifswald, Germany.
    A complex pathomechanism accounts systemic sclerosis as a form of collagenosis. A triad of vasculopathy, autoinflammation, and dysbalance of the fibroblast function can be seen as cause, as well as symptomatic appearance. Comparative with other collagenoses, e. Read More

    Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus.
    PLoS One 2017 16;12(10):e0186414. Epub 2017 Oct 16.
    Department of Rheumatology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
    Although quotient of alpha2 macroglobulin (Qα2MG) was previously reported to be useful for the evaluation of blood-brain barrier (BBB) function, it is not commonly used. We therefore evaluated BBB function among the various subsets of neuropsychiatric systemic lupus erythematosus (NPSLE) using quotient Q α2MG. Furthermore, we determined the correlation between Q α2MG and cerebrospinal (CSF) interleukin (IL)-6 level and quotient complement component 3 (Q C3). Read More

    Systemic lupus erythematosus following meningococcal vaccination.
    Am J Emerg Med 2018 Jan 7;36(1):170.e3-170.e4. Epub 2017 Oct 7.
    University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, United States; Department of Emergency Medicine, Lehigh Valley Health Network, 1240 South Cedar Crest Boulevard, Allentown, PA 18103, United States. Electronic address:
    Systemic erythematosus lupus (SLE) affects multiple organs and involves complex immune dysfunction. Because vaccinations are inherently designed to stimulate the immune response, they have been linked with increased risk for flare of SLE and other autoimmune disorders, and their association with new-onset autoimmune disease has been postulated in several case reports. To our knowledge, this is the first reported case of the meningococcal vaccine precipitating SLE in a previously undiagnosed patient. Read More

    Effect of long-term hydroxychloroquine on vascular events in patients with systemic lupus erythematosus: a database prospective cohort study.
    Rheumatology (Oxford) 2017 Dec;56(12):2212-2221
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Keelung, Taiwan.
    Objectives: The incidence of thromboembolism in patients with SLE is higher than that in the general population. HCQ, widely used to treat lupus, may have vascular protective effects. The aim of this study was to determine whether long-term HCQ exposure is associated with decreased thromboembolism risk in SLE. Read More

    Missing in action-The meaning of cell death in tissue damage and inflammation.
    Immunol Rev 2017 Nov;280(1):26-40
    Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany.
    Billions of cells die every day in higher organisms as part of the normal process of tissue homeostasis. During special conditions like in development, acute infections, mechanical injuries, and immunity, cell death is a common denominator and it exerts profound effects in the outcome of these scenarios. To prevent the accumulation of aged, superfluous, infected, damaged and dead cells, professional phagocytes act in a rapid and efficient manner to clear the battle field and avoid spread of the destruction. Read More

    Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes.
    Endocrinol Diabetes Metab Case Rep 2017 6;2017. Epub 2017 Oct 6.
    Department of Diabetes and Endocrinology, Newham University Hospital, Barts Health NHS Trust, London, UK.
    We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). Read More

    Continous Rituximab treatment for recurrent diffuse alveolar hemorrhage in a patient with systemic lupus erythematosus and antiphosholipid syndrome.
    Respir Med Case Rep 2017 30;22:263-265. Epub 2017 Sep 30.
    Department of Pathology, Aarhus University Hospital, Denmark.
    Diffuse alveolar hemorrhage (DAH) is a rare but potentially fatal complication in systemic lupus erythematosus (SLE). DAH is typically characterized by hemoptysis, dyspnea, new infiltrates on chest x-rays or CT-scans and a drop in hemoglobin. DAH is seen in less than 2% of patients with SLE and carries a high acute mortality risk of up to 70-90%. Read More

    Recent topics in IMiDs and cereblon.
    Rinsho Ketsueki 2017 ;58(10):2067-2073
    Department of Nanoparticle Translational Research, Tokyo Medical University.
    Immunomodulatory drugs (IMiDs) are a new class of anticancer compounds that are derived from thalidomide. Lenalidomide and pomalidomide are well-known IMiDs, and they have already been approved by FDA for the treatment of several diseases, including multiple myeloma. Cereblon (CRBN) is a common primary target for IMiDs. Read More

    The Role of Brain-Reactive Autoantibodies in Brain Pathology and Cognitive Impairment.
    Front Immunol 2017 11;8:1101. Epub 2017 Sep 11.
    The Feinstein Institute for Medical Research, The Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, Northwell Health System, Manhasset, NY, United States.
    Antibodies to different brain proteins have been recently found to be associated with an increasing number of different autoimmune diseases. They need to penetrate the blood-brain barrier (BBB) in order to bind antigens within the central nervous system (CNS). They can target either neuronal or non-neuronal antigen and result in damage either by themselves or in synergy with other inflammatory mediators. Read More

    Borrelia Lymphocytoma Mimicking Butterfly Rash in a Pediatric Patient.
    Am J Dermatopathol 2018 Mar;40(3):216-218
    Friedrichshafen Dermatopathologie, Friedrichshafen, Germany.
    A 5-year-old girl presented with a facial butterfly rash that persisted for 5 months without arthralgia, fever, malaise, photosensitivity, or other symptoms. Lupus erythematosus was clinically suspected. All blood tests were negative or within normal values. Read More

    Sudden Collapse in the First Trimester: Report of Hyperacute Renal Failure Secondary to Collapsing Glomerulopathy as the Initial Presentation of Lupus.
    Cureus 2017 Jul 24;9(7):e1509. Epub 2017 Jul 24.
    Internal Medicine, Quillen College of Medicine, East Tennessee State University.
    Hyperacute renal failure is rarely the initial presentation of systemic lupus erythematosus (SLE). Pregnancy can predispose untreated lupus nephritis to acute renal failure. Collapsing glomerulopathy (CG) type of renal failure is not a new clinicopathological entity. Read More

    A large retrospective review of persistent proteinuria in children.
    J Formos Med Assoc 2017 Sep 21. Epub 2017 Sep 21.
    Department of Pediatrics, National Taiwan University Children's Hospital, College of Medicine, National Taiwan University, No. 8 Chung-Shan South Rd., Taipei, 10061, Taiwan. Electronic address:
    Background: Proteinuria is a common finding in children. It may be due to a benign cause, but it can also represent early renal injury. Of children with persistent proteinuria noted in mass urine screening programs, 35% have a urine protein level greater than 100 mg/dl and many of them are associated with many underlying renal diseases. Read More

    1 OF 83