4,777 results match your criteria Lupus Erythematosus Acute

Perfusion image guided mechanical thrombectomy combined with tirofiban successfully revascularize systemic lupus erythematosus related acute large vessel occlusion: A case report.

Medicine (Baltimore) 2021 May;100(18):e25779

Department of Neurological Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Rationale: Systemic lupus erythematosus (SLE) is an important cause of stroke, more than a half the cases present as acute ischemic stroke. Thrombolysis is an effective choice in most cases, but for large vessel occlusion, mechanical thrombectomy is more effective. Here we reported a case of SLE-related stroke with left middle cerebral artery (MCA) occlusion, who was successfully treated by MT and tirofiban. Read More

View Article and Full-Text PDF

Lupus acute cardiomyopathy is highly responsive to intravenous immunoglobulin treatment: Case series and literature review.

Medicine (Baltimore) 2021 May;100(18):e25591

Department of Internal Medicine E, Meir Medical Center, Kfar Saba.

Introduction: Intravenous immunoglobulin (IVIg) is currently used with considerable success for the treatment of many autoimmune diseases, including systemic lupus erythematosus (SLE). Among its various indications, IVIg has also been found to be beneficial in myocarditis, whether or not it is associated with an autoimmune disease. Nevertheless, data regarding IVIg treatment for myocarditis/cardiomyopathy in patients with SLE are sparse. Read More

View Article and Full-Text PDF

Interleukin-12 exacerbates symptoms in an MRL/MpJ-Faslpr mouse model of systemic lupus erythematosus.

Exp Ther Med 2021 Jun 15;21(6):627. Epub 2021 Apr 15.

Institute of Acute Disorders of Traditional Chinese Internal Medicine, The First Clinical College of Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China.

Interleukin (IL)-12 modulates the generation and function of a variety of immune cells and serves an important role in the pathogenesis of autoimmune diseases. However, the precise role of IL-12 in the pathogenesis of systemic lupus erythematosus (SLE) remains to be elucidated. In the present study, the serum levels of IL-12 in patients with SLE were determined using an ELISA. Read More

View Article and Full-Text PDF

Failure of Anticoagulation to Prevent Stroke in Context of Lupus-Associated Anti-Phospholipid Syndrome and Mild COVID-19.

J Stroke Cerebrovasc Dis 2021 Apr 12:105817. Epub 2021 Apr 12.

Department of Neurology, University of Florida, Gainesville, USA. Electronic address:

Hypercoagulability and virally-mediated vascular inflammation have become well-recognized features of the SARS-CoV-2 virus infection, COVID-19. Of growing concern is the apparent ineffectiveness of therapeutic anticoagulation in preventing thromboembolic events among some at-risk patient subtypes with COVID-19. We present a 43-year-old female with a history of seropositive-antiphospholipid syndrome and systemic lupus erythematosus who developed an acute ischemic stroke in the setting of mild COVID-19 infection despite adherence to chronic systemic anticoagulation. Read More

View Article and Full-Text PDF

Neuromyelitis Optica Spectrum Disorders (NMOSD) and Connective Tissue Disease (CTD): an Update for the Rheumatologist.

Curr Rheumatol Rep 2021 Apr 28;23(6):33. Epub 2021 Apr 28.

Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, TX, USA.

Purpose Of Review: To review the pathophysiology, presentation, and treatment of neuromyelitis optica spectrum disorder (NMOSD) and its association with systemic lupus erythematosus (SLE) and Sjogren's syndrome (SS).

Recent Findings: NMOSD is an autoimmune disorder of the central nervous system that primarily targets astrocytes. Although the prevalence is unknown, the coexistence of NMOSD and SLE/SS is well-recognized. Read More

View Article and Full-Text PDF

A and A adenosine receptors play a protective role to reduce prevalence of autoimmunity following tissue damage.

Clin Exp Immunol 2021 Apr 24. Epub 2021 Apr 24.

Departments of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka University Medical Center, Beer-Sheva, Israel.

Adenosine is a potent modulator that has a tremendous effect on the immune system. Adenosine affects T cells activity, and necessary in maintaining T helper/Tregs ratio. Adenosine signalling is also involved in activating neutrophils and the formation of neutrophil extracellular traps (NETs), which has been linked to autoimmune disorders. Read More

View Article and Full-Text PDF

Risk factors for multi-joint disease in patients with glucocorticoid-induced osteonecrosis.

Osteoporos Int 2021 Apr 20. Epub 2021 Apr 20.

Endocrinology Service, Hospital for Special Surgery, 535 East 70th Street, New York, NY, USA.

This study investigated risk factors for osteonecrosis involving multiple joints (MJON) among glucocorticoid-treated patients. The best predictor of MJON was cumulative oral glucocorticoid dose. Risk of MJON was 12-fold higher in patients who had a second risk factor for osteonecrosis. Read More

View Article and Full-Text PDF

Identification of 10 Hub Genes and an miRNA-mRNA Regulatory Network in Acute Kawasaki Disease.

Front Genet 2021 25;12:585058. Epub 2021 Mar 25.

Cardiology Department, Children's Hospital of Soochow University, Suzhou, China.

Kawasaki disease (KD) causes acute systemic vasculitis and has unknown etiology. Since the acute stage of KD is the most relevant, the aim of the present study was to identify hub genes in acute KD by bioinformatics analysis. We also aimed at constructing microRNA (miRNA)-messenger RNA (mRNA) regulatory networks associated with acute KD based on previously identified differentially expressed miRNAs (DE-miRNAs). Read More

View Article and Full-Text PDF

Lupus-Like Glomerulonephritis Associated With Regorafenib, a Multikinase Inhibitor.

Kidney Med 2021 Mar-Apr;3(2):294-298. Epub 2021 Feb 5.

Section of Nephrology, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.

Drug-induced lupus glomerular diseases have historically been associated with hydralazine, but new drugs that modify the growth, metabolism, and immunity of cells are increasingly found to cause glomerular disease. This includes anti-tumor necrotic factor and other antibody agents used in cancer treatment. Multitarget tyrosine kinases such as regorafenib are increasingly used in metastatic malignancies with good outcomes. Read More

View Article and Full-Text PDF
February 2021

Recent Insight on the Management of Lupus Erythematosus Alopecia.

Clin Cosmet Investig Dermatol 2021 30;14:333-347. Epub 2021 Mar 30.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Lupus erythematosus (LE) is a chronic autoimmune condition with a wide spectrum of clinical presentations. Alopecias, both non-scarring and scarring, frequently occur in the context of LE and can assume several different patterns. Furthermore, alopecia occurring with LE may be considered LE-specific if LE-specific features are present on histology; otherwise, alopecia is considered non-LE-specific. Read More

View Article and Full-Text PDF

Femoral Head Osteonecrosis in Systemic Lupus Erythematosus: Total Hip Arthroplasty Outcomes and Considerations.

JBJS Rev 2021 04 5;9(4). Epub 2021 Apr 5.

Department of Orthopedic Surgery, New York University Langone Orthopedic Hospital, New York, NY.

»: Osteonecrosis of the femoral head disproportionately affects patients with systemic lupus erythematosus (SLE) and is the most frequent indication for total hip arthroplasty (THA) in these patients.

»: Patients with SLE are more likely to undergo THA than those without the disease, and they elect for the procedure at a younger age. More arthroplasty procedures are currently being performed on patients with SLE as the all-cause rate of arthroplasty is increasing similarly to that of the general population. Read More

View Article and Full-Text PDF

A case of longitudinally extensive transverse myelitis in an 80-year-old patient with systemic lupus erythematous and anti-aquaporin 4 antibodies.

Mult Scler Relat Disord 2021 Mar 13;51:102899. Epub 2021 Mar 13.

Neurological Department, "A. Manzoni" Hospital, ASST Lecco, Via dell'Eremo 9/11, 23900 Lecco, Italy.

Background: Systemic Lupus Erythematous is a systemic autoimmune disease with multiorgan inflammation. Clinical manifestations are variable and may involve the Central Nervous System. Acute transverse myelitis is a rare complication. Read More

View Article and Full-Text PDF

Smoking associates with distinct clinical phenotypes in patients with systemic lupus erythematosus: a nationwide Danish cross-sectional study.

Lupus Sci Med 2021 04;8(1)

Lupus and Vasculitis Clinic, Copenhagen University Hospital Center for Rheumatology and Spine Diseases, Copenhagen, Hovedstaden, Denmark.

Objectives: SLE displays large clinical heterogeneity that beyond genetic factors may be determined by environmental exposures. In this Danish nationwide study, we aimed to determine if clinical subsets of SLE were associated with smoking history.

Methods: At each of six participating centres, incident or prevalent inpatients and outpatients with SLE were consecutively included. Read More

View Article and Full-Text PDF

Autoimmune Complications in Hematologic Neoplasms.

Cancers (Basel) 2021 Mar 26;13(7). Epub 2021 Mar 26.

Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Autoimmune cytopenias (AICy) and autoimmune diseases (AID) can complicate both lymphoid and myeloid neoplasms, and often represent a diagnostic and therapeutic challenge. While autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP) are well known, other rarer AICy (autoimmune neutropenia, aplastic anemia, and pure red cell aplasia) and AID (systemic lupus erythematosus, rheumatoid arthritis, vasculitis, thyroiditis, and others) are poorly recognized. This review analyses the available literature of the last 30 years regarding the occurrence of AICy/AID in different onco-hematologic conditions. Read More

View Article and Full-Text PDF

Respiratory Manifestations in Systemic Lupus Erythematosus.

Pharmaceuticals (Basel) 2021 Mar 18;14(3). Epub 2021 Mar 18.

Internal Medicine and Nephrology Unit, Department of Life, Health & Environmental Sciences, University of L'Aquila and Department of Medicine, ASL 1 Avezzano-Sulmona-L'Aquila, 67100 L'Aquila, Italy.

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by a wide spectrum of clinical manifestations. The respiratory system can be involved in up to 50-70% of patients and be the presenting manifestation of the disease in 4-5% of cases. Every part of the respiratory part can be involved, and the severity can vary from mild self-limiting to life threatening forms. Read More

View Article and Full-Text PDF

Cross-Talk among Polymorphonuclear Neutrophils, Immune, and Non-Immune Cells via Released Cytokines, Granule Proteins, Microvesicles, and Neutrophil Extracellular Trap Formation: A Novel Concept of Biology and Pathobiology for Neutrophils.

Int J Mol Sci 2021 Mar 18;22(6). Epub 2021 Mar 18.

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 10002, Taiwan.

Polymorphonuclear neutrophils (PMNs) are traditionally regarded as professional phagocytic and acute inflammatory cells that engulf the microbial pathogens. However, accumulating data have suggested that PMNs are multi-potential cells exhibiting many important biological functions in addition to phagocytosis. These newly found novel activities of PMN include production of different kinds of cytokines/chemokines/growth factors, release of neutrophil extracellular traps (NET)/ectosomes/exosomes and trogocytosis (membrane exchange) with neighboring cells for modulating innate, and adaptive immune responses. Read More

View Article and Full-Text PDF

Acute pericardial tamponade: The initial manifestation of systemic lupus erythematosus with Graves' hyperthyroidism.

Lupus 2021 Mar 30:9612033211004729. Epub 2021 Mar 30.

Department of Emergency Medicine, 117865Tianjin Medical University General Hospital, Tianjin, P.R. China.

Acute pericardial tamponade, which can cause obstructive shock, is a serious life-threatening medical emergency that can be readily reversed by timely identification and appropriate intervention. Acute pericardial tamponade can occur for a number of reasons, including idiopathic, malignancy, uremia, iatrogenic, post-myocardial infarction, infection, collagen vascular, hypothyroidism, and others. Systemic lupus erythematosus (SLE) and hyperthyroidism associated with pericardial tamponade are rarely reported. Read More

View Article and Full-Text PDF

Use of F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography to successfully diagnose central nervous system vasculitis in systemic lupus erythematosus and antiphospholipid syndrome: a case report.

Mod Rheumatol Case Rep 2021 Apr 15:1-7. Epub 2021 Apr 15.

Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

A 53-year-old woman was admitted to our hospital for headache secondary to an acute subdural haematoma in the right cerebellar tentorium. She had been diagnosed with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) two years before presentation and was initiated on prednisolone (PSL) 40 mg/day as induction therapy, which was subsequently tapered to 5 mg/day. Her thrombocytopenia and renal impairment were managed by warfarin with a target prothrombin time-international normalised ratio of 2-3. Read More

View Article and Full-Text PDF

Toxic epidermal necrolysis-like lupus.

Clin Exp Dermatol 2021 Mar 24. Epub 2021 Mar 24.

Dermatology Department, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester, UK.

Toxic epidermal necrosis (TEN)-like lupus is a rare condition characterized by epidermal loss and mucosal ulceration occurring in patients with acute severe flares of systemic lupus erythematosus. The clinical picture may mimic drug-induced Stevens-Johnson syndrome/TEN; however, the absence of a suitable culprit drug, and the context of acute lupus point to the correct diagnosis. In a case series of three patients, further discriminating features included a slower onset of epidermal loss, more limited mucosal ulceration and a lack of ocular involvement when compared with drug-induced TEN. Read More

View Article and Full-Text PDF

Rare Association of Non-Bacterial Thrombotic Endocarditis, Myocardial Infarction, and Acute Limb Ischemia Secondary to Rheumatoid Arthritis: Comprehensive Case Series With Literature Review.

Cureus 2021 Feb 12;13(2):e13319. Epub 2021 Feb 12.

Cardiology, Saint Michael's Medical Center, Newark, USA.

Most cases of non-bacterial thrombotic endocarditis (NBTE) tend to be related to malignancy or rheumatologic and autoimmune disorders like systemic lupus erythematosus. Rheumatoid arthritis (RA) itself has been associated with increased atherosclerosis, coronary artery plaque formation, and endothelial damage. However, it is rare to see NBTE in RA, simultaneously presenting with the acute coronary syndrome and acute limb ischemia due to distant embolization. Read More

View Article and Full-Text PDF
February 2021

Unusual Presentation of Systemic Lupus Erythematosus in a Young Male: A Case Report.

J Clin Exp Hepatol 2021 Mar-Apr;11(2):264-269. Epub 2020 Jun 12.

Department of Pathology, Kalinga Institute of Medical Science, Bhubaneswar, Odisha, India.

Hepatic involvement in systemic lupus erythematosus (SLE) is common but described infrequently. Liver is usually never the primary organ to be affected in lupus. Again hepatic involvement probably does not carry much prognostic importance though it may correlate with lupus activity. Read More

View Article and Full-Text PDF

COVID-19 in Patients with Multiple Sclerosis: Associations with Disease-Modifying Therapies.

CNS Drugs 2021 03 20;35(3):317-330. Epub 2021 Mar 20.

Biogen, Cambridge, MA, USA.

Background: Disease-modifying therapies (DMTs) for multiple sclerosis (MS) target immunity and have the potential to increase the risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and alter its clinical course. We assessed these risks in patients with MS (PwMS).

Objective: The objective of this study was to describe the overall risk of coronavirus disease 2019 (COVID-19) infection, severe disease course, and potential population-level predictors of COVID-19 infection in PwMS, and to provide a context using a cohort of patients with systemic lupus erythematosus (SLE). Read More

View Article and Full-Text PDF

Rapid Induction of Pulmonary Inflammation, Autoimmune Gene Expression, and Ectopic Lymphoid Neogenesis Following Acute Silica Exposure in Lupus-Prone Mice.

Front Immunol 2021 23;12:635138. Epub 2021 Feb 23.

Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States.

Occupational exposure to crystalline silica (cSiO) is etiologically associated with systemic lupus erythematosus (lupus) and other autoimmune diseases. cSiO's autoimmune effects in humans can be mimicked chronically in female lupus-prone NZBWF1 mice following repeated exposure to the particle. However, the immediate and short-term effects of cSiO in this widely used model of autoimmune disease are not well-understood. Read More

View Article and Full-Text PDF
February 2021

Clinical features, severity and outcome of acute pancreatitis in systemic lupus erythematosus.

Rheumatol Int 2021 Mar 16. Epub 2021 Mar 16.

Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India.

Acute pancreatitis (AP) is a rare but life threatening manifestation of Systemic Lupus Erythematosus (SLE). The current study aims to study the clinical characteristics, severity, mortality, and outcome of SLE-related AP in Indian population. We retrospectively reviewed medical records of patients with SLE who had AP in the past. Read More

View Article and Full-Text PDF

The extent of tubulointerstitial inflammation is an independent predictor of renal survival in lupus nephritis.

J Nephrol 2021 Mar 15. Epub 2021 Mar 15.

Department of Nephrology and Renal Transplantation, Hospital Clínic, Barcelona, Spain.

Background And Objective: Lupus nephritis (LN) is a major complication in patients with systemic lupus erythematosus (SLE). Tubulointerstitial injury is an inflammatory process that, if not attenuated, can promote renal damage. Despite this, the current 2003 ISN/RPS "glomerulocentric" classification does not include a score for tubulointerstitial injury. Read More

View Article and Full-Text PDF

[Deescalation and glucocorticoid-free treatment in SLE].

Z Rheumatol 2021 May 15;80(4):332-338. Epub 2021 Mar 15.

Poliklinik für Rheumatologie und Hiller Forschungszentrum, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Treatment of systemic lupus erythematosus (SLE) without permanent glucocorticoid therapy is inconceivable for most patients and their physicians. Although we have significantly improved the prognosis of SLE, management remains constrained by a lack of effective, targeted therapies and the lack of evidence-based approaches to the use of existing compounds. For example, for glucocorticoids (GC), which are used continuously in a majority of patients, there are no evidence-based recommendations for initiation, tapering, and cessation in the treatment of SLE. Read More

View Article and Full-Text PDF

[Pericarditis in contemporary therapeutic clinic: nosological spectrum, approaches to diagnosis and treatment].

Ter Arkh 2020 Dec 15;92(12):10-18. Epub 2020 Dec 15.

Sechenov First Moscow State Medical University (Sechenov University).

Aim: To analyze the register of pericarditis in a therapeutic clinic, to evaluate their nosological spectrum, to optimize approaches to diagnosis and treatment.

Materials And Methods: For the period 20072018, the register includes 76 patients with the diagnosis of pericarditis (average age 53.115. Read More

View Article and Full-Text PDF
December 2020

Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases.

Front Immunol 2021 26;12:638867. Epub 2021 Feb 26.

Department of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.

The human microbiota is the community of microorganisms that live upon or within their human host. The microbiota consists of various microorganisms including bacteria, fungi, viruses, and archaea; the gut microbiota is comprised mostly of bacteria. Many bacterial species within the gut microbiome grow as biofilms, which are multicellular communities embedded in an extracellular matrix. Read More

View Article and Full-Text PDF
February 2021

Acute porphyric polyneuropathy in a pregnant patient with systemic lupus erythematosus.

Neurologia 2021 Mar 11. Epub 2021 Mar 11.

Neurology Department, Department of Neurosciences and Mental Health, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Avenida Professor Egas Moniz, 1649-035, Lisboa, Portugal; Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal.

View Article and Full-Text PDF

Systemic lupus erythematosus and COVID-19 during pregnancy.

Lupus 2021 Mar 14:9612033211002270. Epub 2021 Mar 14.

Department of Rheumatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

The ongoing corona virus disease 2019 (COVID-19) pandemic is having a worldwide impact. Valuable information on the clinical characteristics of COVID-19 in pregnant patients with an autoimmune disease, such as systemic lupus erythematosus (SLE), is currently lacking. Herein, we describe the clinical presentation of 2 pregnant patients with SLE and mild symptomatic COVID-19 infection. Read More

View Article and Full-Text PDF