Search our Database of Scientific Publications and Authors

I’m looking for a

    4060 results match your criteria Lupus Erythematosus Acute

    1 OF 82

    Renal transplantation in systemic lupus erythematosus: Comparison of graft survival with other causes of end-stage renal disease.
    Reumatol Clin 2017 Aug 14. Epub 2017 Aug 14.
    Servicio de Reumatología, UMAE, Hospital de Especialidades «Dr. Bernardo Sepúlveda Gutiérrez», Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.
    Introduction: End-stage renal disease (ESRD) due to lupus nephritis (LN) occurs in 10%-30% of patients. Initially systemic lupus erythematosus (SLE) was a contraindication for kidney transplantation (KT). Today, long-term graft survival remains controversial. Read More

    Urticaria vasculitis in a child: a case report and literature review.
    Clin Case Rep 2017 Aug 21;5(8):1255-1257. Epub 2017 Jun 21.
    Department of DermatologyHospital Universitario Severo OchoaAvenida de Orellana28911LeganésMadridSpain.
    Annular urticarial lesions in a child must establish a main differential diagnosis with urticaria multiforme, common urticaria, acute hemorrhagic edema of infancy, erythema marginatum, erythema annulare centrifugum, annular erythema in childhood, erythema multiforme, Sweet's syndrome, Schönlein-Henoch purpura, erythematosus lupus, several systemic vasculitis, and serum sickness. Read More

    Cerebral tuberculosis in a patient with systemic lupus erythematosus following cyclophosphamide treatment: a case report.
    Lupus 2017 Jan 1:961203317722849. Epub 2017 Jan 1.
    1 Louise Coote Lupus Unit, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.
    Central nervous system (CNS) tuberculosis (TB) is a rare but catastrophic event in patients with systemic lupus erythematosus (SLE). Here we report a case of cerebral TB in a patient with lupus myocarditis and nephritis, following cyclophosphamide immunosuppression. To our knowledge this is the first reported case of cerebral TB in SLE in a non-endemic country. Read More

    Acute Myocardial Infarction in Young Systemic Lupus Erythematosus Patient with Normal Coronary Arteries.
    Cureus 2017 Jun 19;9(6):e1370. Epub 2017 Jun 19.
    Cardiology, West Virginia University - Charleston Division.
    A 34-year-old female with a past medical history of systemic lupus erythematosus (SLE) and a deep venous thrombosis experienced substernal chest pain for 24 hours. Her physical exam was remarkable for brown macular rash over the face. Her initial electrocardiogram showed ST depression in lead V3-V6 along with an elevated troponin I level of 1. Read More

    Off-label use of rituximab in autoimmune disease in the Top End of the Northern Territory, 2008-2016.
    Intern Med J 2017 Jul 25. Epub 2017 Jul 25.
    clinical immunologist and allergist, Cairns Hospital, QLD.
    Background: Rituximab, an anti-CD20 B cell depleting monoclonal antibody, is increasingly prescribed off-label for a range of autoimmune diseases. There has not previously been an audit of off-label rituximab use in the Northern Territory, where the majority of patients are Aboriginal.

    Aims: To retrospectively evaluate off-label rituximab use in autoimmune diseases in the Top End of the Northern Territory. Read More

    Serum ferritin as an activity marker for granulamotosis with polyangiitis.
    Ren Fail 2017 Nov;39(1):566-569
    a Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine , Gazi University , Ankara , Turkey.
    Background: Serum ferritin correlates well with the activities of systemic lupus erythematosus (SLE) and dermatomyositis, but it has not been previously studied in patients with vasculitis.

    Methods: Medical records of granulomatosis with polyangiitis (GPA, Wegener's granulomatosis) patients with at least six months of regular follow-up were evaluated. The activity of GPA was assessed with Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG). Read More

    Myelitis in systemic lupus erythematosus.
    J Clin Neurosci 2017 Jul 7. Epub 2017 Jul 7.
    Department of Nephrology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China; Department of Medicine, The University of Hong Kong - Queen Mary Hospital, Pokfulam Road, Hong Kong, China. Electronic address:
    SLE-associated acute transverse myelitis (ATM) is a rare, but potentially severe complication of Systemic lupus erythematosus (SLE), and may lead to significant motor, sensory and autonomic dysfunctions in the central nervous system resulting in marked neurological deficits. It is important to recognize its clinical feature to allow timely diagnosis and management of this condition. In this review, we aimed to provide the reader with the understanding of its clinical presentation and classification, the underlying pathological, MRI (magnetic resonance imaging) appearance, and current status of management, with an emphasis on recent discoveries and advancements. Read More

    Systemic lupus erythematosus, following prodromal idiopathic thrombocytopenic purpura, presenting with skin lesions resembling malignant atrophic papulosis.
    Clin Exp Dermatol 2017 Jul 10. Epub 2017 Jul 10.
    Department of Dermatology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.
    Systemic lupus erythematosus (SLE) is an autoimmune disease. Its incidence in the UK is approximately 1 per 10 000. Cutaneous involvement, encompassing acute, subacute and chronic disease, occurs in over two-thirds of cases, and can often be the first clue to diagnosis. Read More

    Unusual acute lupus hemophagocytic syndrome - a test of diagnostic criteria: a case report.
    J Med Case Rep 2017 Jul 7;11(1):185. Epub 2017 Jul 7.
    Postgraduate Institute of Medicine, University of Colombo, Colombo, Sri Lanka.
    Background: Hemophagocytic lymphohistiocytosis is an aggressive life-threatening syndrome of excessive immune activation. Hemophagocytic lymphohistiocytosis due to systemic lupus erythematosus is described as acute lupus hemophagocytic syndrome. Acute lupus hemophagocytic syndrome presenting with negative antinuclear antibody is uncommon. Read More

    Successful treatment using corticosteroid combined antibiotic for acute acalculous cholecystitis patients with systemic lupus erythematosus.
    Medicine (Baltimore) 2017 Jul;96(27):e7478
    Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, P.R. China.
    There is no consensus of treatments for acute acalculous cholecystitis with systemic lupus erythematosus (SLE). The study was aimed to investigate the effect of the corticosteroid for these patients.A series of patients who were diagnosed as acute acalculous cholecystitis with SLE in the period from January 2012 to December 2016 at our hospital were included. Read More

    Cardiovascular and Pulmonary Manifestations of Systemic Lupus Erythematosus.
    Curr Rheumatol Rev 2017 Jul 4. Epub 2017 Jul 4.
    University Health Network, Toronto, Ontario. Canada.
    Background: Systemic lupus erythematosus (SLE) is characterized by various clinical manifestations and immunologic abnormalities. Among clinical manifestations, cardiovascular and respiratory system involvement is increasingly recognized as critical for patients' prognosis.

    Objective: Heart involvement, most commonly presents with pericarditis. Read More

    A Retrospective Study of Acute Renal Failure in Children: Its Incidence, Etiology, Complications and Prognosis.
    Cureus 2017 May 25;9(5):e1274. Epub 2017 May 25.
    Department of Paediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, P.R.China.
    Background: Acute renal failure (ARF) developed due to various causes and may lead to significant morbidity and mortality among pediatric patients.

    Objectives: The study was conducted to determine the incidence, etiology, outcome of treatment and clinical presentation of ARF in pediatric patients in Somalia.

    Methods: Comprehensive case history of 39 pediatric patients below 12 years of age, admitted with renal diseases in four tertiary care hospitals in Hargeisa and Borama cities in Somalia during December 2015 to November 2016. Read More

    Acute tubulointerstitial nephritis in an HLA-B27-positive patient with axial spondyloarthritis being treated with adalimumab.
    Reumatol Clin 2017 Jun 14. Epub 2017 Jun 14.
    Servicio de Anatomía Patológica, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
    Antagonists of tumor necrosis factor-alpha (ATNF) are used for the treatment of multiple diseases such as psoriatic arthritis, Crohn's disease, ankylosing spondylitis and juvenile idiopathic arthritis, usually, when they are refractory to first-line treatment(1). The use of ATNF has been associated with the induction of autoimmune diseases such as systemic lupus erythematosus-like disease, vasculitis, sarcoidosis-like diseases and, recently, acute granulomatous tubulointerstitial nephritis. We report a case of acute nongranulomatous tubulointerstitial nephritis in an HLA-B27-positive patient with axial spondyloarthritis and Crohn's disease being treated with adalimumab. Read More

    Peroxynitrite-modified histone as a pathophysiological biomarker in autoimmune diseases.
    Biochimie 2017 Sep 12;140:1-9. Epub 2017 Jun 12.
    Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India.
    Under physiological conditions, reactive nitrogen and oxygen species are produced continuously. However, excess of these radicals may damage biomolecules like lipids, proteins and nucleic acids. These reactive species have been implicated in many disease conditions including acute/chronic inflammation, rheumatoid arthritis (RA), neurodegenerative diseases and systemic lupus erythematosus (SLE). Read More

    [Clinical Presentations and Prognostic Factors in Systemic Lupus Erythematosus Patients with Sepsis Admitted to Intensive Care Unit].
    Sichuan Da Xue Xue Bao Yi Xue Ban 2016 07;47(4):594-598
    Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu 610041, China.
    Objectives: To explore the characteristics and prognostic factors associated with the death of systemic lupus erythematosus (SLE) with sepsis in intensive care unit(ICU).

    Methods: Clinical and laboratory documents of SLE patients with sepsis from Jan 2010 to Dec 2014 were retrospectively analyzed, including active organ involvement, systemic lupus erythematosus disease activity index (SLEDAI) score, acute physiology and chronic health evaluation (APACHE) Ⅱ score, sites of infection and organisms cultured. Prognostic factors were analyzed by multivariate logistic regression analysis. Read More

    Ventilator Management of Bronchopleural Fistula Secondary to Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia in a Pregnant Patient with Systemic Lupus Erythematosus.
    Case Rep Med 2017 14;2017:1492910. Epub 2017 May 14.
    Department of Pulmonary and Critical Care, King Fahad Medical City, P.O. Box 59046, Riyadh 11525, Saudi Arabia.
    Managing mechanical ventilation in patient with bronchopleural fistula with coexisting acute respiratory distress syndrome is a challenging situation for the intensivist. We are reporting a case of a pregnant patient with systemic lupus erythematosus on immunosuppressive medications who developed methicillin-resistant Staphylococcus aureus necrotizing pneumonia complicated by bronchopleural fistula and acute respiratory distress syndrome. Read More

    Pattern of acute glomerulonephritis in adult population in Dubai: A single-center experience.
    Saudi J Kidney Dis Transpl 2017 May-Jun;28(3):571-578
    Department of Nephrology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab Emirates.
    Epidemiological data of renal diseases have great geographic variability throughout the world. Due to the lack of a national renal data registry system, there is no information on the prevalence rate, clinical and pathological features of various glomerulonephritis (GN) in the United Arab Emirates (UAE). In a retrospective cross-sectional study, we analyzed 158 renal biopsies done in Dubai Hospital, UAE, between the years of 2005 and September 2014, with an aim to determine the prevalence rate and frequency of different pathological patterns of GN in adult patients who presented with proteinuria ± hematuria. Read More

    Diffuse Alveolar Hemorrhage in Systemic Lupus Erythematosus: Histopathologic Features and Clinical Correlations.
    Case Rep Pathol 2017 27;2017:1936282. Epub 2017 Apr 27.
    Department of Pathology, Yale University, 310 Cedar Street, New Haven, CT 06510, USA.
    The case of a 16-year-old African-American girl with systemic lupus erythematosus, who developed diffuse alveolar hemorrhage with fatal consequences, is described. Diffuse alveolar hemorrhage is a rare but serious complication of systemic lupus. It occurs in three distinct but overlapping phenotypes, acute capillaritis, bland pulmonary hemorrhage, and diffuse alveolar damage, each of which is associated with a different group of underlying conditions. Read More

    Cardiac tamponade as an initial presentation for systemic lupus erythematosus.
    Am J Emerg Med 2017 Aug 29;35(8):1213.e1-1213.e4. Epub 2017 Apr 29.
    Cardiology, Lincoln Medical and Mental Health Center, United States.
    Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease which follows a relapsing and remitting course that can manifest in any organ system. While classic manifestations consist of arthralgia, myalgia, frank arthritis, a malar rash and renal failure to name a few, cardiac tamponade, however, is a far less common and far more dangerous presentation. We highlight the case of a 61year-old male with complaints of acute onset shortness of breath and generalized body aches associated with a fever and chills in the ER. Read More

    AP-1 Expression and its Clinical Relevance in Immune Disorders and Cancer.
    Am J Med Sci 2017 May 1;353(5):474-483. Epub 2017 Feb 1.
    Bone Marrow Transplantation Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    The inflammatory response is known to have a significant role in certain autoimmune diseases and malignancies. We review current knowledge regarding the functions of activator protein 1 (AP-1) as an important modulator in several immune disorders and carcinomas. AP-1 is overexpressed in rheumatoid arthritis and in long-term allogeneic hematopoietic stem cell transplantation survivors; however, decreased expression of AP-1 has been observed in psoriasis, systematic lupus erythematosus and in patients who do not survive after hematopoietic stem cell transplantation. Read More

    [CMV associated acute liver failure in a patient receiving tocilizumab for systemic lupus erythematosus].
    Z Gastroenterol 2017 May 12;55(5):467-472. Epub 2017 May 12.
    Klinik II, Abteilung Gastroenterologie und Endokrinologie, Universitätsmedizin Rostock Zentrum für Innere Medizin, Rostock, Germany.
    A 41-year-old female patient was admitted because of febrile jaundice and acute liver failure. The quick and the bilirubin were 21 % and 258 µmol/l, and there was hepatic encephalopathy I°. AST and AP had a maximum of 612 and 215 U/l. Read More

    Speckle tracking echocardiography in acute lupus myocarditis: comparison to conventional echocardiography.
    Echo Res Pract 2017 Jun 10;4(2):9-19. Epub 2017 May 10.
    Division Cardiology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.
    Aims: Lupus myocarditis occurs in 5-10% of patients with systemic lupus erythematosus (SLE). No single feature is diagnostic of lupus myocarditis. Speckle tracking echocardiography (STE) can detect subclinical left ventricular dysfunction in SLE patients, with limited research on its utility in clinical lupus myocarditis. Read More

    Clinical spectrum and therapeutic management of systemic lupus erythematosus-associated macrophage activation syndrome: A study of 103 episodes in 89 adult patients.
    Autoimmun Rev 2017 Jul 5;16(7):743-749. Epub 2017 May 5.
    Service d'immunologie Clinique et médecine interne, CHU de Strasbourg, France.
    Objectives: Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory syndrome that can occur during systemic lupus erythematosus (SLE). Data on MAS in adult SLE patients are very limited. The aim of this study is to describe the clinical characteristics, laboratory findings, treatments, and outcomes of a large series of SLE-associated MAS. Read More

    Risk of hemorrhagic transformation after ischemic stroke in patients with antiphospholipid antibody syndrome.
    Neurol Res 2017 Jun 5;39(6):477-483. Epub 2017 May 5.
    d Department of Neurology , McGovern Medical School, University of Texas Health Science Center , Houston , TX , USA.
    Background And Purpose: Several rheumatologic conditions including systemic lupus erythematosus, antiphospholipid antibody (APS) syndrome, rheumatoid arthritis, and scleroderma are known risk factors for stroke. The risk of hemorrhagic transformation after an acute ischemic stroke (AIS) in these patients is not known.

    Methods: We queried the Nationwide Inpatient Sample (NIS) data between 2010 and 2012 with ICD 9 diagnostic codes for AIS. Read More

    Spontaneous massive hemopneumothorax: Double trouble with a twist.
    Lung India 2017 May-Jun;34(3):283-286
    Metro Centre for Respiratory Diseases, Metro Multispecialty Hospital, Noida, Uttar Pradesh, India.
    Spontaneous hemopneumothorax (SHP) is observed in 3%-7% cases of spontaneous pneumothorax where the tear of an adhesion can lead to bleeding with associated hemothorax. This condition has been reported in patients with hemophilia, sarcoidosis, congenital cystic adenomatoid malformation, systemic lupus erythematosus, etc., Here, we describe an unusual case of acute massive SHP in a 62-year-old male who underwent a percutaneous transluminal coronary angioplasty (PTCA) and presented with worsening dyspnea over the next 3 days. Read More

    Lupus glomerulonephritis in 788 Chinese children: a multi-centre clinical and histopathological analysis based on 549 renal biopsies.
    Paediatr Int Child Health 2017 May 2:1-6. Epub 2017 May 2.
    a Division of Paediatric Nephrology, Department of Paediatrics , Central South University , Changsha , P. R. China.
    Background: System lupus erythematosus (SLE) is a severe multisystem autoimmune disease.

    Objective: To describe the clinical and pathological features, treatment, and renal outcome in children under 18 years with lupus nephritis (LN).

    Methods: The study was undertaken by a questionnaire completed in 26 Grade 3A hospitals' paediatric renal units in China. Read More

    Management of cardiovascular risk in systemic lupus erythematosus: a systematic review.
    Lupus 2017 Jan 1:961203317704710. Epub 2017 Jan 1.
    2 UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain.
    Systemic lupus erythematosus is associated with accelerated atherosclerosis and increased risk of cardiovascular complications. The aim of this study was to review the effectiveness of interventions for primary and secondary prevention of cardiovascular events and mortality and to review the effectiveness of interventions for cardiovascular risk factor reduction in systemic lupus erythematosus patients. A systematic review was conducted. Read More

    Association of anti-triosephosphate isomerase antibodies with aseptic meningitis in patients with neuropsychiatric systemic lupus erythematosus.
    Clin Rheumatol 2017 Jul 28;36(7):1655-1659. Epub 2017 Apr 28.
    Fukushima Medical University School of Medicine, Department of Rheumatology, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
    Autoantibodies to triosephosphate isomerase (TPI), which is an important glycolytic enzyme in red blood cells and neuronal cells, have been reported to be associated with neuropsychiatric systemic lupus erythematosus (NPSLE) pathogenesis. However, the clinical features regarding anti-TPI antibody (anti-TPI)-positive NPSLE are not yet known. The aim of this study is to investigate the clinical features of anti-TPI-positive NPSLE patients using anti-TPI index values determined by enzyme-linked immunosorbent assay (ELISA). Read More

    Kidney transplantation for end-stage renal disease in lupus nephritis, a very safe procedure: a single Latin American transplant center experience.
    Lupus 2017 Jan 1:961203317696591. Epub 2017 Jan 1.
    2 ICESI University School of Medicine, Cali, Colombia.
    Background Lupus nephritis (LN) is one of the most frequent complications of SLE and occurs in up to 50% of cases depending on the studied population. Of these, approximately 20% progress to end-stage renal disease (ESRD), with the treatment of choice being a kidney transplant. Objective The objective of this study was to describe the clinical outcome of patients transplanted due to LN, compared with patients transplanted for other causes, in a Latin American population from the Fundación Valle del Lili in Cali, Colombia. Read More

    Serum C-reactive protein concentrations in Nova Scotia Duck Tolling Retrievers with immune-mediated rheumatic disease.
    Acta Vet Scand 2017 Apr 17;59(1):21. Epub 2017 Apr 17.
    Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Box 7054, 750 07, Uppsala, Sweden.
    Nova Scotia Duck Tolling Retrievers (NSDTRs) are a dog breed often affected by immune-mediated rheumatic disease (IMRD), a disorder characterised by chronic stiffness and joint pain. Most, but not all, dogs with IMRD, have antinuclear antibodies (ANA), which are also commonly present in the autoimmune disease systemic lupus erythematosus (SLE). The clinical and diagnostic findings of IMRD indicate that it is an SLE-related disorder. Read More

    Use of SLICC criteria in a large, diverse lupus registry enables SLE classification of a subset of ACR-designated subjects with incomplete lupus.
    Lupus Sci Med 2017 17;4(1):e000176. Epub 2017 Mar 17.
    Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
    Objective: SLE is traditionally classified using the American College of Rheumatology (ACR) criteria. The Systemic Lupus International Collaborating Clinics (SLICC) recently validated an alternative system. This study examined large cohorts of subjects with SLE and incomplete lupus erythematosus (ILE) to compare the impact of ACR and SLICC criteria. Read More

    Drugs with antidepressant properties affect tryptophan metabolites differently in rodent models with depression-like behavior.
    J Neurochem 2017 Jul 16;142(1):118-131. Epub 2017 May 16.
    Translational Neuropsychiatry Unit, Risskov, Denmark.
    The metabolism of tryptophan through kynurenine and serotonin pathways is linked to depression. Here, effects of different drugs with antidepressant properties (vortioxetine, fluoxetine, and ketamine) on various tryptophan metabolites in different brain regions and plasma were examined using tandem mass spectrometry (LC-MS/MS), in Flinders Sensitive Line rats, a genetic rat model of depression, and its controls: Flinders Sensitive Line and Sprague-Dawley rats. Protein levels of kynurenine pathway enzymes were measured in the brains and livers of these rat strains. Read More

    Accidental hydroxychloroquine overdose resulting in neurotoxic vestibulopathy.
    BMJ Case Rep 2017 Apr 12;2017. Epub 2017 Apr 12.
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Hydroxychloroquine is an oral antimalarial medication commonly used off-label for a variety of rheumatological conditions, including systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome and dermatomyositis. We present a case of a 64-year-old woman who presented with acute onset headache, bilateral tinnitus, and left-sided facial numbness and tingling in the setting of accidentally overdosing on hydroxychloroquine. By the next morning, the patient began to experience worsening in the tingling sensation and it eventually spread to her left arm, thigh and distal extremities. Read More

    Systemic lupus erythematosus: A possible cause of non-alcoholic Wernicke's encephalopathy.
    S Afr Med J 2017 Mar 29;107(4):299-301. Epub 2017 Mar 29.
    Division of Rheumatology, Department of Medicine, Faculty of Health Sciences, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
    We report a young woman with systemic lupus erythematosus (SLE) and an acute cerebellar ataxia. A history of poor appetite and vomiting preceded the inco-ordination. Ataxia in SLE has been well described, but is nevertheless uncommon. Read More

    Anti-ribosomal P antibody: a multicenter study in childhood-onset systemic lupus erythematosus patients.
    Lupus 2017 Apr;26(5):484-489
    1 Pediatric Rheumatology Unit, Children's Institute, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Brazil.
    Objectives Anti-ribosomal P protein (anti-P) autoantibodies are highly specific for systemic lupus erythematosus (SLE). However, the evaluation of this autoantibody in childhood-onset SLE (cSLE) populations has been limited to a few small series, hampering the interpretation of the clinical and laboratorial associations. Therefore, the objective of this multicenter cohort study was to evaluate demographic, clinical/laboratorial features, and disease damage score in cSLE patients with and without the presence of anti-P antibody. Read More

    A critical analysis of the tools to evaluate neuropsychiatric lupus.
    Lupus 2017 Apr;26(5):504-509
    1 Centre for Rheumatology, Division of Medicine, University College London, London, UK.
    Neuropsychiatric symptoms occur commonly in patients with systemic lupus erythematosus, but they are not always due to active disease. It is crucial to identify cases that are due to active systemic lupus erythematosus so that appropriate treatment can be instituted. There is no single serological or imaging test that distinguishes active neuropsychiatric systemic lupus erythematosus from neuropsychiatric manifestations caused by other factors such as infection. Read More

    Acute-Onset Chest Pain in a 17-Year-Old Female Adolescent With Systemic Lupus Erythematosus.
    Pediatr Emerg Care 2017 May;33(5):346-349
    From the Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD.
    We report the case of a 17-year-old adolescent girl with systemic lupus erythematosus with disseminated pneumococcal infection leading to purulent pericarditis with cardiac tamponade. Although pericarditis is not an uncommon entity in autoimmune diseases such as systemic lupus erythematosus, purulent pericarditis is a rare cause (<1%) of this presentation. Read More

    Acute acalculous cholecystitis in patients with systemic lupus erythematosus: A unique form of disease flare.
    Lupus 2017 Sep 29;26(10):1101-1105. Epub 2017 Mar 29.
    Department of Rheumatology and Clinical Immunology, Clinical Immunology Center, The Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Objective We aimed to investigate the clinical features of acute acalculous cholecystitis (AAC) in patients with systemic lupus erythematosus (SLE). Methods SLE patients with AAC hospitalized in the Peking Union Medical College Hospital (PUMCH) from January 2001 to September 2015 were retrospectively analyzed. Their medical records were systematically reviewed. Read More

    Mesenteric inflammatory veno-occlusive disease of the spleen metasynchronous with two arterial thrombotic events in systemic lupus erythematosus.
    Lupus 2017 Jan 1:961203317700980. Epub 2017 Jan 1.
    1 Immunology and Allergy, Department of Internal Medicine Specialties, University Hospital and School of Medicine, Geneva, Switzerland.
    Vasculitides, particularly those affecting small vessels, are known to complicate systemic lupus erythematosus (SLE); however, isolated venulitis of the mesenteric bed has rarely been reported. Here we relate the case of a 46-year-old woman with SLE who presented with acute abdominal pain due to artery thrombosis and extended splenic ischemia requiring splenectomy. The histological examination revealed diffuse venulitis in the absence of arterial vasculitis consistent with the definition of mesenteric inflammatory veno-occlusive disease (MIVOD). Read More

    Systemic Lupus Erythematosus Is Associated With Increased Adverse Postoperative Renal Outcomes and Mortality: A Historical Cohort Study Using Administrative Health Data.
    Anesth Analg 2017 Apr;124(4):1118-1126
    From the *Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Ohio; †Department of Anesthesiology and Reanimation, Etimesgut Military Hospital, Ankara/Turkey; and ‡Department of Quantitative Health Sciences, Anesthesiology Institute, Cleveland Clinic, Ohio.
    Background: Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease that mainly harms kidneys, heart, lungs, and nervous system. Effects of surgical stimulus and anesthesia combined with SLE-related pathologies may increase morbidity and mortality. Therefore, we aimed to evaluate the association between SLE (versus none) and postoperative renal, cardiac, and in-hospital mortality complications among patients undergoing major surgeries. Read More

    Etiological profile of noncompressive myelopathies in a tertiary care hospital of Northeast India.
    Ann Indian Acad Neurol 2017 Jan-Mar;20(1):41-50
    Department of Neurology, Gauhati Medical College and Hospital, Guwahati, Assam, India.
    Background: The discovery of antibodies against aquaporin-4 and evolving concepts of noncompressive myelopathies in the 21(st) century have made a major impact on the etiological profile of these diseases, with few cases turning out to be idiopathic.

    Objective: To find causes of noncompressive myelopathy in a tertiary care hospital of Northeast India.

    Materials And Methods: An observational study was carried out in the Neurology Department of Gauhati Medical College, Guwahati, from September 2013 to February 2016. Read More

    A study of acute muscle dysfunction with particular reference to dengue myopathy.
    Ann Indian Acad Neurol 2017 Jan-Mar;20(1):13-22
    Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.
    Background: Acute myopathy is a common cause of acute motor quadriparesis which has various etiologies with different courses of illness and prognosis depending on the cause. Understanding this diversity helps us in proper approach toward diagnosis, predicting the prognosis, and possible complications and in improving the treatments that are being provided. This study was planned to study the clinical, electrophysiological, and etiological profile of patients presenting with acute myopathy. Read More

    Different genetic alteration of A20 in a Sézary syndrome case with Vα2-Jα22 T cell clone.
    Asia Pac J Clin Oncol 2017 Mar 14. Epub 2017 Mar 14.
    Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.
    Background: The comprehensive genetic alterations underlying the pathogenesis of Sézary syndrome (SS) remains largely unknown. Previous studies showed that alterations of tumor necrosis factor-α-induced protein 3 gene (TNFAIP3; A20) are frequent in SS. In this study, we characterized the mutation and polymorphisms of A20 in a case with SS and compared with the genetic feature of A20 in T-cell acute lymphoblastic leukemia (T-ALL). Read More

    Neurological Manifestations in Systemic Lupus Erythematosus: A Single Centre Study from North East India.
    J Clin Diagn Res 2017 Jan 1;11(1):OC05-OC09. Epub 2017 Jan 1.
    Assistant Professor, Department of Neurology, NEIGRIHMS , Shillong, Meghalaya, India .
    Introduction: Neurological manifestations although common in Systemic Lupus Erythematosus (SLE), are often not recognized due to their diversed and varied presentation. Therefore, the study was planned to highlight the pattern of neurological involvement in SLE to help in early recognition.

    Aim: To study the pattern of neurological involvement in SLE and its correlation with disease activity and different investigation. Read More

    Collapsing glomerulopathy in systemic lupus erythematosus.
    BMJ Case Rep 2017 Feb 27;2017. Epub 2017 Feb 27.
    Department of Nephrology and Hypertension, Mayo Clinic, Jacksonville, Florida, USA.
    Collapsing glomerulopathy (CG) is a rare disease that can be associated with multiple other disorders. It usually leads to poor prognosis with a high percentage of patients progressing to end-stage renal disease. In this article, we illustrate a clinical case of CG associated with systemic lupus erythematosus that had a prompt response to mycophenolate and prednisone. Read More

    Tetrahydroisoquinolines: New Inhibitors of Neutrophil Extracellular Trap (NET) Formation.
    Chembiochem 2017 May 31;18(10):888-893. Epub 2017 Mar 31.
    Department of Chemical Biology, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
    Neutrophils are short-lived leukocytes that migrate to sites of infection as part of the acute immune response, where they phagocytose, degranulate, and form neutrophil extracellular traps (NETs). During NET formation, the nuclear lobules of neutrophils disappear and the chromatin expands and, accessorized with neutrophilic granule proteins, is expelled. NETs can be pathogenic in, for example, sepsis, cancer, and autoimmune and cardiovascular diseases. Read More

    1 OF 82