4,313 results match your criteria Lupus Erythematosus Acute


Bisphosphonate-induced orbital inflammation in a patient on chronic immunosuppressive therapy.

BMC Ophthalmol 2019 Feb 14;19(1):51. Epub 2019 Feb 14.

Department of Ophthalmology, University of Kansas School of Medicine, 7400 State Line Rd, Prairie Village, Kansas, USA.

Background: To report a case of orbital inflammation after bisphosphonate infusion in a patient who was already receiving immunosuppressive therapy.

Case Presentation: A 56-year-old woman presented to the ophthalmology clinic with acute onset of right eye pain 24 h after receiving her first Zolendronic acid infusion. She has a past medical history of chronic inflammatory demyelinating polyneuropathy, Sjogren's syndrome, and systemic lupus erythematosus that have been controlled with immunosuppressive therapy for three years. Read More

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http://dx.doi.org/10.1186/s12886-019-1063-8DOI Listing
February 2019
1 Read

Blood-brain barrier disruption and neuroinflammation as pathophysiological mechanisms of the diffuse manifestations of neuropsychiatric systemic lupus erythematosus.

Autoimmun Rev 2019 Feb 11. Epub 2019 Feb 11.

Universidad de Antioquia, Facultad de Medicina, Grupo de Inmunología Celular e Inmunogenética-GICIG, Medellín, Colombia.

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.12.004DOI Listing
February 2019

Use of Intravenous Immunoglobulin Therapy at Unconventional Doses in Refractory Fulminant Systemic Lupus Erythematosus.

Eur J Case Rep Intern Med 2018 27;5(9):000934. Epub 2018 Sep 27.

Rare Diseases and Periodic Fevers Research Centre, Department of Internal Medicine, Agostino Gemelli University Hospital Foundation, Catholic University of the Sacred Heart, Rome, Italy.

The use of human intravenous immunoglobulins (IVIg) in systemic lupus erythematosus (SLE) currently relies on evidence from small case series and is mainly regarded as an off-label strategy in cases that are refractory to conventional therapies or poorly controlled with high doses of corticosteroids. Standard dosage regimens typically entail the administration of a total amount of 2 g/kg of IVIg divided into five consecutive days in order to minimize the risk of severe adverse events. We herein describe the case of a 28-year-old woman with a known history of antiphospholipid syndrome (APS) who was admitted to our hospital following fulminant onset of SLE in spite of ongoing immunosuppressive therapy. Read More

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http://dx.doi.org/10.12890/2018_000934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346821PMC
September 2018
1 Read

Choroid thickness profile in patients with lupus nephritis.

Lupus 2019 Feb 12:961203319828525. Epub 2019 Feb 12.

1 Centro Hospitalar de Vila Nova de Gaia Espinho, Vila Nova de Gaia, Portugal.

Background: Choroidopathy is a rare manifestation of systemic lupus erythematosus (SLE). This entity is associated with active phases of severe SLE and it is frequently accompanied by acute kidney failure, central nervous system involvement and coagulopathy.

Purpose: To evaluate the choroid thickness of patients with lupus nephritis (LN) without choroidopathy, and to compare this with that of age-matched SLE patients without LN and healthy control subjects. Read More

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http://dx.doi.org/10.1177/0961203319828525DOI Listing
February 2019
1 Read

Predictors of Mortality in Pulmonary Haemorrhage during SLE: A Single Centre Study Over Eleven Years.

Open Access Maced J Med Sci 2019 Jan 14;7(1):92-96. Epub 2019 Jan 14.

Department of Nephrology, King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia.

Background: Pulmonary haemorrhage (PH) is a serious complication during Systemic Lupus Erythematosus (SLE).

Aim: The aim was to present data on 12 patients of SLE with classic symptoms and signs of PH admitted throughout eleven years.

Methods: This retrospective study was carried out at King Abdul Aziz Specialist hospital in Taif-a tertiary care hospital in the western region of Saudi Arabia. Read More

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http://dx.doi.org/10.3889/oamjms.2019.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352490PMC
January 2019
1 Read

Cell Membrane-Derived Microvesicles in Systemic Inflammatory Response.

Folia Biol (Praha) 2018 ;64(4):113-124

Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Human body reacts to physical, chemical and biological insults with a complex inflammatory reaction. Crucial components and executors of this response are endothelial cells, platelets, white blood cells, plasmatic coagulation system, and complement. Endothelial injury and inflammation are associated with elevated blood levels of cell membrane-derived microvesicles. Read More

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January 2018
3 Reads

[Clinical value of multiplex immune assay of antinuclear antibodies in systemic lupus erythematosus.]

Klin Lab Diagn 2018 ;63(7):434-438

A.S. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, 111123, Moscow, Russia.

A promising trend in the diagnosis of systemic autoimmune diseases is the multiplex immune assay (MIA) of autoantibodies and other laboratory biomarkers using microchips. The aim of the work was to study the diagnostic and prognostic significance of MIA antinuclear antibody (ANA) profiles in systemic lupus erythematosus (SLE). 94 patients with SLE, 70 patients with other rheumatic diseases and 30 healthy donors were examined. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-7-434-438DOI Listing
January 2018
1 Read

Varied responses to and efficacies of hydroxychloroquine treatment according to cutaneous lupus erythematosus subtypes in Japanese patients.

J Dermatol 2019 Feb 5. Epub 2019 Feb 5.

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Hydroxychloroquine is recommended as the first-line systemic treatment for cutaneous lupus erythematosus (CLE) in Western countries, and it was approved in Japan in 2016. However, the efficacy of hydroxychloroquine in various cutaneous lupus erythematosus subtypes in Japanese patients has not been elucidated to date. Therefore, we investigated the efficacy of hydroxychloroquine for the treatment of cutaneous manifestations according to CLE subtypes in Japanese patients. Read More

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http://dx.doi.org/10.1111/1346-8138.14802DOI Listing
February 2019
1 Read

Yield of Screening Tests for Systemic Vasculitis in Young Adults with Ischemic Stroke.

Eur Neurol 2019 Feb 4;80(5-6):245-248. Epub 2019 Feb 4.

Department of Neurology, Inha University School of Medicine, Incheon, Republic of

Systemic vasculitis, which can involve the brain, may be one of the causes of stroke in young adults; therefore, a test panel for systemic vasculitis is considered for some young stroke patients. However, little is known about this test's yield as a screening test in young adults with ischemic stroke. We evaluated the yield of a panel for systemic vasculitis as a screening test in young patients with ischemic stroke. Read More

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http://dx.doi.org/10.1159/000496373DOI Listing
February 2019
1 Read
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Season Dependent Changes in the Expression of Protein Kinase C Isoenzymes in a Female Patient with Systemic Lupus Erythematosus.

Pathol Oncol Res 2019 Feb 4. Epub 2019 Feb 4.

Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zs. str. 22, Debrecen, H-4032, Hungary.

We aimed to answer the question whether the decreased expression of protein kinase C (PKC) isoenzymes in the peripheral blood mononuclear cells (PBMC) of patients with systemic lupus erythematosus (SLE) is inherited or not. For this reason we examined the expression of PKC isoenzymes in a European white girl with acute SLE and in her healthy mother and father simultaneously in summer and winter during one year using western blotting and densitometry. We found that in the father the expression of PKC isoenzymes did not differ from that of eight healthy controls included women and men. Read More

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http://dx.doi.org/10.1007/s12253-019-00591-7DOI Listing
February 2019
1 Read

Tetra-arsenic tetra-sulfide ameliorates lupus syndromes by inhibiting IL-17 producing double negative T cells.

Dermatol Ther 2019 Feb 1:e12849. Epub 2019 Feb 1.

Department of Dermatology, People's Hospital of Peking University, Beijing, China.

Systemic lupus erythematosus (SLE) is an autoimmune disease of uncertain etiology that affects multiple tissues and organs. Tetra-arsenic tetra-sulfide (As S ), a traditional Chinese medicine, is effective on acute promyelocytic leukemia with mild side effects. In our previous study, BXSB lupus-prone mice treated with As S has showed improved monocytosis, decreased serum interleukin (IL)-6 and suppressed skin, liver and renal lesions with well-tolerance. Read More

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http://dx.doi.org/10.1111/dth.12849DOI Listing
February 2019
2 Reads

The Management of Heavy Menstrual Bleeding After Percutaneous Coronary Intervention in a Woman of Reproductive Age.

Front Pharmacol 2018 15;9:1573. Epub 2019 Jan 15.

Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Heavy menstrual bleeding (HMB), previously known as menorrhagia, is in place with heavy flow and longer lasting days of bleeding during menstrual period, sequentially leading to anemia. We reported a rare case of HMB in a 33-year-old patient after percutaneous coronary intervention (PCI), who presented with acute coronary syndromes (ACS), uremia and systemic lupus erythematosus before PCI. This patient received three times of hemodialysis weekly (Monday, Wednesday, and Friday). Read More

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http://dx.doi.org/10.3389/fphar.2018.01573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341068PMC
January 2019
1 Read

Systemic Lupus Erythematosus-Related Pancreatitis in Children: Severe and Lethal Form.

Case Rep Pediatr 2018 31;2018:4612754. Epub 2018 Dec 31.

Pediatric ICU Department, Mother-Child Pole, Mohammed VI University Hospital, Marrakesh, Morocco.

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease of unknown cause, characterized by multisystemic involvement. Its occurrence in children is rare, and acute pancreatitis is exceptional in this matter. Its diagnosis is clinical, biological, and radiological. Read More

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http://dx.doi.org/10.1155/2018/4612754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332963PMC
December 2018
3 Reads

Therapeutic plasma exchange for pediatric nonrenal disease indications and outcomes: A single-center experience.

Asian J Transfus Sci 2018 Jul-Dec;12(2):127-135

Department of Paediatrics, Apollo Children's Hospitals, Chennai, Tamil Nadu, India.

Introduction: Outcome data in pediatric plasma exchange, especially in nonrenal indications are scarce. We aimed to evaluate its role and outcome in our patients.

Subjects And Methods: A retrospective study of children admitted in the year 2016 to the Pediatric Intensive Care Unit requiring plasma exchange for nonrenal indications was undertaken. Read More

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http://dx.doi.org/10.4103/ajts.AJTS_123_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327757PMC
January 2019
3 Reads

Severe Thrombocytopenia in Patient with Dermatomyositis.

Curr Health Sci J 2018 Apr-Jun;44(2):192-196. Epub 2018 Mar 27.

Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania.

Dermatomyositis (DM) is part of a heterogeneous group of systemic diseases called idiopathic inflammatory myopathies. As in other autoimmune connective tissue diseases (CTD), abnormalities of hematopoietic tissue and/or peripheral blood cells may develop and represent an important prognostic factor. Most common CTD associated with thrombocytopenia (TP) are systemic lupus erythematosus and antiphospholipid syndrome. Read More

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http://dx.doi.org/10.12865/CHSJ.44.02.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320470PMC
March 2018
1 Read

Acute Unilateral Vision Loss Due to Optic Neuropathy in a Patient with Systemic Lupus Erythematosus.

Am J Case Rep 2019 Jan 23;20:97-100. Epub 2019 Jan 23.

Department of Internal Medicine, Mayo Clinic in Florida, Jacksonville, FL, USA.

BACKGROUND Systemic lupus erythematosus (SLE) causes sight-threatening, ophthalmologic problems that are frequently challenging to manage. Optic neuropathy is a rare ophthalmological complication of SLE that can progress to total bilateral vision loss if not identified and treated rapidly. We describe a patient with SLE who presented with an acute, painless unilateral optic neuropathy who subsequently experienced partial recovery of vision when treated with high-dose intravenous corticosteroids. Read More

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http://dx.doi.org/10.12659/AJCR.912875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350674PMC
January 2019

Internet-based self-diagnosis of Lyme disease caused death in a young woman with systemic lupus erythematosus.

Joint Bone Spine 2019 Jan 17. Epub 2019 Jan 17.

Department of Immunology, 2ndFaculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, 150 06, Prague 5, Czech Republic.

In the majority of cases, Lyme disease responds well to antibiotic treatment. Nevertheless, some patients may suffer from chronic nonspecific symptoms such as musculoskeletal pain and fatigue, termed as a post-treatment Lyme disease syndrome (PTLDS). Proper understanding and management of PTLDS may prevent from the incorrect diagnosis of patients with autoimmune, neuromuscular or other somatic disorders, where identical symptoms are equally prevalent. Read More

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http://dx.doi.org/10.1016/j.jbspin.2018.12.011DOI Listing
January 2019
1 Read

Systemic Lupus Erythematosus is Not Necessarily a Contraindication to Adjuvant Breast Radiation Therapy.

Cureus 2018 Nov 13;10(11):e3584. Epub 2018 Nov 13.

Oncology, University of Calgary, Calgary, CAN.

A 41-year-old woman presented with pT4dN1aM0, right-sided, inflammatory breast cancer. She had a co-morbid diagnosis of systemic lupus erythematosus (SLE) at the age of 20 and was found to have significant kidney involvement (lupus-associated nephritis) at the age of 28. She went on to receive six cycles of neoadjuvant chemotherapy consisting of fluorouracil, epirubicin, cyclophosphamide, and docetaxcel (FEC-D) after which she had radiographically stable disease. Read More

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https://www.cureus.com/articles/15987-systemic-lupus-erythem
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http://dx.doi.org/10.7759/cureus.3584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334888PMC
November 2018
10 Reads

Sub-acute Cardiac Tamponade as an Early Clinical Presentation of Childhood Systemic Lupus Erythematosus: A Case Report.

Cureus 2018 Oct 22;10(10):e3478. Epub 2018 Oct 22.

Surgery, Jinnah Sindh Medical University, Karachi, PAK.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple systems by the process of inflammation and formation of auto-antibodies. When it presents in childhood, it is referred to as childhood systemic lupus erythematosus (cSLE). Cardiac tamponade is a rare but potentially lethal complication of cSLE, even rarer as an initial presentation. Read More

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http://dx.doi.org/10.7759/cureus.3478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318088PMC
October 2018
2 Reads

Therapy Side Effects in Systemic Lupus Erythematosus.

Curr Health Sci J 2018 Jul-Sep;44(3):316-321. Epub 2018 Jul 15.

Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.

Glucosteroids (GS) are widely used drugs for various inflammatory pathologies (Nephrotic syndrome, Proliferative glomerulonephritis, Extramembrane glomerulonephritis, Nephropathy of the Nodous Poliarterita (PAN), Nephropathy from purple Henoch-Schonlein, lupus nephropathy (LN), Acute adrenal insufficiency Waterhouse-Friederichsen, Chronic adrenal insufficiency Addison, Systemic Lupus Erythematosus (SLE), Polymyositis and dermatomyositis, Chronic granulomatosis, Crohn's disease, Hemorrhagic rectocolitis, Hemolytic anemias, Acute leukemias and chronic lymphocytic leukemia, Hodgkin's lymphoma). Although they are prescribed for their anti-inflammatory and immunosuppressive properties, they also have many side effects, hyperglycemia being one of the most common and representative, which is why these drugs need careful monitoring when administered over the long term. This paper presents the case of a 39 year old patient diagnosed with systemic lupus erythematosus (SLE) with class IV lupus nephropathy (LN) who developed numerous complications due to the pathogenic side effects: diabetes, amenorrhea, recurrent infections, and depression. Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311221PMC
July 2018
6 Reads

Haemophagocytic lymphohistiocytosis with collapsing lupus podocytopathy as an unusual manifestation of systemic lupus erythematosus with APOL1 double-risk alleles.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Division of Nephrology, Department of Medicine, Jacobi Medical Center at Albert Einstein College of Medicine, Bronx, New York, USA.

Haemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening syndrome caused by excessive immune activation. Secondary HLH has been described in autoimmune diseases. We detail the case of a 28-year-old African American woman who developed HLH in the setting of systemic lupus erythematosus with collapsing lupus podocytopathy superimposed on mesangial proliferative lupus nephritis class II. Read More

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http://dx.doi.org/10.1136/bcr-2018-227860DOI Listing
January 2019
2 Reads

Fulminant Guillain-Barré syndrome in a patient with systemic lupus erythematosus.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.

A 45-year-old man with a history of systemic lupus erythematosus presented with progressive weakness and areflexia. Electromyogram revealed reduced motor and sensory amplitudes without demyelinating features. He was clinically diagnosed with the acute motor and sensory axonal neuropathy variant of Guillain-Barré syndrome. Read More

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http://dx.doi.org/10.1136/bcr-2018-226634DOI Listing
January 2019
3 Reads

Seizure and Acute Vision Loss in a Filipino Lupus Patient: A Case of Posterior Reversible Encephalopathy Syndrome with Intraparenchymal Hemorrhage.

Case Rep Med 2018 9;2018:4238676. Epub 2018 Dec 9.

Section of Rheumatology, Department of Medicine, UP-Philippine General Hospital, Manila, Philippines.

Posterior reversible encephalopathy syndrome (PRES) is a rare and poorly understood neurologic condition that has been described in some patients with systemic lupus erythematosus (SLE). Intracerebral hemorrhage is a unique and atypical presentation of PRES and has been described only in a small number of patients with SLE. We present the case of a 33-year-old female, diagnosed with SLE and active nephritis, who was admitted for seizures. Read More

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https://www.hindawi.com/journals/crim/2018/4238676/
Publisher Site
http://dx.doi.org/10.1155/2018/4238676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304919PMC
December 2018
7 Reads

Acute Appendicitis in a Patient with Systemic Lupus Erythematosus.

Acta Med Indones 2018 Oct;50(4):332-335

Department of Internal Medicine, Faculty of Medicine, Airlanggan University - dr. Soetomo Hospital, Surabaya, Indonesia.

Systemic lupus erythematosus (SLE) is a chronic excacerbative autoimmune disease with wide clinical spectrum. Gastrointestinal manifestasion is a frequent clinical manifestasion seen in SLE. Management with glucocorticoid and non-steroid anti-inflammatory drugs (NSAID) can mask the gastrointestinal symptoms in patient with SLE. Read More

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October 2018
4 Reads

[Clinical and pathological characteristics and outcome of 46 children with autoimmune hepatitis].

Zhonghua Er Ke Za Zhi 2019 Jan;57(1):40-45

Pediatric Liver Diseases Treatment and Research Center, Fifth Medical Center, General Hospital of the People's Liberation Army (PLA), Beijing 100039, China.

To review and analyze the clinical and pathological data of children with autoimmune hepatitis (AIH). Medical records of 46 patients hospitalized in Pediatric Liver Diseases Treatment and Research Center, Fifth Medical Center, General Hospital of People's Liberation Army(PLA) from April 2012 to April 2018 were extracted. Medical data included type of AIH, clinical manifestations, biochemical parameters, liver biopsy results, and outcomes of treatment were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.01.010DOI Listing
January 2019
3 Reads

Munchausen by proxy syndrome mimicking childhood-onset systemic lupus erythematosus.

Lupus 2019 Jan 7:961203318821156. Epub 2019 Jan 7.

1 Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Childhood-onset systemic lupus erythematosus (cSLE) is a chronic inflammatory multisystem autoimmune disease that requires multiple differential diagnoses. Munchausen by proxy syndrome (MBPS) is a form of child abuse, where a caregiver intentionally creates a medical history and induces or fabricates signs or disease in a patient. To our knowledge, there is no case report of MBPS mimicking cSLE diagnosis. Read More

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http://dx.doi.org/10.1177/0961203318821156DOI Listing
January 2019
2 Reads

The clinical features and mortality risk factors of cytomegalovirus infection in patients with systemic lupus erythematosus.

J Microbiol Immunol Infect 2019 Feb 16;52(1):114-121. Epub 2018 Dec 16.

Division of Allergy, Immunology, & Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; National Yang-Ming University Faculty of Medicine, Taipei, Taiwan. Electronic address:

Background: The clinical features and outcomes of cytomegalovirus (CMV) diseases in patients with systemic lupus erythematosus (SLE) are unknown. We analyzed such data from a medical center in Taiwan.

Methods: We retrospectively reviewed the medical records of patients with SLE who were diagnosed with CMV diseases between 2006 and 2016 in Taipei Veterans General Hospital Taiwan. Read More

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http://dx.doi.org/10.1016/j.jmii.2018.12.002DOI Listing
February 2019
1 Read

Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival.

Liver Int 2018 Dec 29. Epub 2018 Dec 29.

Liver Unit, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.

Background: Several lines of evidence indicate that decompensated cirrhosis is characterized by the presence of systemic inflammation. Hepatorenal syndrome (HRS-AKI) is a unique type of renal failure that occurs at late stages of cirrhosis. However, confirmation of the presence and significance of such inflammatory response in HRS-AKI is lacking. Read More

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http://dx.doi.org/10.1111/liv.14037DOI Listing
December 2018
4 Reads

Clinicopathological profile of pediatric renal biopsies at a tertiary care hospital, Pakistan.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1403-1409

The Kidney Center, Karachi, Pakistan.

Renal biopsy is an important tool for the diagnosis of acute and chronic glomerular diseases in children. We aimed to analyze the spectrum of clinical indications and histopathological patterns (HPP) in children who underwent renal biopsy (RB). This is a retrospective review of case records of 108 renal biopsies carried out from January 2010 to December 2015 at the Pediatric Nephrology Department, National Institute of Child Health Karachi, Pakistan. Read More

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http://www.sjkdt.org/text.asp?2018/29/6/1403/248290
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http://dx.doi.org/10.4103/1319-2442.248290DOI Listing
December 2018
13 Reads

INASL Guidelines on Management of Hepatitis B Virus Infection in Patients receiving Chemotherapy, Biologicals, Immunosupressants, or Corticosteroids.

J Clin Exp Hepatol 2018 Dec 26;8(4):403-431. Epub 2018 Jun 26.

Hepatology & Liver Transplant (Medicine), Fortis Escorts Liver & Digestive Diseases Institute (FELDI), Fortis Escorts Hospital, Delhi, India.

Hepatitis B Virus (HBV) reactivation in patients receiving chemotherapy, biologicals, immunosupressants, or corticosteroids is emerging to be an important cause of morbidity and mortality in patients with current or prior exposure to HBV infection. These patients suffer a dual onslaught of illness: one from the primary disease for which they are receiving the culprit drug that led to HBV reactivation, and the other from HBV reactivation itself. The HBV reactivation not only leads to a compromised liver function, which may culminate into hepatic failure; it also adversely impacts the treatment outcome of the primary illness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09736883183009
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http://dx.doi.org/10.1016/j.jceh.2018.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286881PMC
December 2018
19 Reads

IgM-mediated Warm Autoimmune Hemolytic Anemia: An Autopsy Report.

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine, Ako City Hospital, Japan.

A 79-year-old man with Sjogren's syndrome and systemic lupus erythematosus developed acute impaired consciousness and hemolytic anemia. The patient's red blood cells agglutinated spontaneously at 25-37°C. The treatment of red blood cells with 2-mercaptoethanol resulted in the loss of spontaneous agglutination. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.1291-18DOI Listing
December 2018
8 Reads

Intravenous immunoglobulins for rheumatic disorders and thromboembolic events-a case series and review of the literature.

Immunol Res 2018 Dec 19. Epub 2018 Dec 19.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

To report the temporal association between a series of thromboembolic events and intravenous immunoglobulin infusion in patients with rheumatic diseases, and to review the literature on the subject. The clinical presentation, course, and outcome of thromboembolic events occurring post-immunoglobulin infusion in nine patients is described. A web-based literature review using the PubMed database from 1996 to 2017 was performed, searching for the keywords: thrombosis, thromboembolism, intravenous immunoglobulin, pulmonary embolism, deep vein thrombosis, cerebrovascular event, and acute myocardial infarction. Read More

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http://dx.doi.org/10.1007/s12026-018-9047-yDOI Listing
December 2018
2 Reads

[Posterior reversible encephalopathy syndrome in systemic lupus erythematosus: a case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1102-1107

Department of Rheumatology and Immunology, Peking University First Hospital, Beijing 100034, China.

This case report concerns a 22-year-old woman who had been diagnosed with systemic lupus erythematosus (SLE). She had intermittent fever, butterfly erythema, photosensitivity, oral ulcers, and multiple arthralgia in the past seven years, but she did not adhere to regular treatments. The edema of the lower extremities and face aggravated in the recent two weeks, so she was admitted to our Department of Rheumatology and Clinical Immunology. Read More

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December 2018
2 Reads

[Case series and clinical analysis of 14 cases of catastrophic antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1033-1038

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

Objective: Catastrophic antiphospholipid syndrome (CAPS), also known as Asherson's syndrome, is a special subtype of antiphospholipid syndrome (APS) characterized by multiple intravascular thrombosis involving multiple organs systems or tissues simultaneously or continuously, high titer antiphospholipid antibodies and high mortality rate. This article's aims was to analyze the clinical manifestation, laboratory examination and treatment therapy of CAPS for the purpose of improving the understanding, diagnosis and treatment of the disease in clinical practice.

Methods: Retrospective analysis and descriptive statistics were applied to the clinical manifestations and laboratory findings of 14 CAPS cases from APS Shanghai Database (APS-SH) with catastrophic antiphospholipid. Read More

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December 2018
1 Read

From A to D: A Unique Case Report of Recovery after Longitudinal Myelitis Related to Lupus.

Am J Phys Med Rehabil 2018 Dec 14. Epub 2018 Dec 14.

HealthPartners Neuroscience Center, St. Paul, MN, USA.

Longitudinal myelitis secondary to an acute flare of systemic lupus erythematosus (SLE) has been reported in the literature. There have been few published cases of complete functional recovery in patients with systemic lupus erythematosus related longitudinal myelitis (SLE-LM). Of those cases, none have described in detail the rehabilitation course of treatment. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001117DOI Listing
December 2018
6 Reads

Use of Consensus Methodology to Determine Candidate Items for Systemic Lupus Erythematosus Classification Criteria.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

S.R. Johnson MD PhD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, Mount Sinai Hospital; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. D. Khanna MD MS, Division of Rheumatology, Department of Medicine, University of Michigan, USA. R. Cervera MD PhD FRCP, Hospital Clínic, Barcelona, Spain. N. Costedoat-Chalumeau MD PhD AP-HP, Cochin Hospital, Internal Medicine Department, Centre de référence maladies auto-immunes et systémiques rares d'île de France, Paris, France ; Université Paris Descartes-Sorbonne Paris Cité, Paris, France ; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. D.D. Gladman MD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. B.H. Hahn MD, University of California Los Angeles, Los Angeles, USA. F. Hiepe MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. J. Sánchez-Guerrero MD MSc, Division of Rheumatology, Department of Medicine Mount Sinai Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada; and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. E. Massarotti MD, Brigham and Women's Hospital, Boston MA; Harvard Medical School, Boston, USA. D.T. Boumpas MD FACP FACR, National and Kapodestrian University of Athens, and Biomedical Research Foundation of the Athens Academy, Athens, Greece. K.H Costenbader MD MPH, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, USA. D. Daikh MD, University of California, San Francisco, USA. D. Jayne MD FRCP FRCPE FMedSci, Department of Medicine, University of Cambridge, United Kingdom. T. Dörner MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. D.L. Kamen MD MSCR, Medical University of South Carolina, Charleston, USA. M. Mosca MD PhD, University of Pisa, Italy. R. Ramsey-Goldman MD DrPH, Northwestern University Feinberg School of Medicine, Chicago, USA. J.S. Smolen MD, Medical University of Vienna, Austria. D. Wofsy MD, University of California, San Francisco, USA. M. Aringer MD, University Medical Center and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany. Address correspondence to Sindhu Johnson MD PhD, Division of Rheumatology, Ground Floor, East Wing, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada, M5T 2S8. Phone 1-416-603-6417 Fax.1-416-603- 4348. Email:

Objective: Given the complexity and heterogeneity of systemic lupus erythematosus (SLE), high performing classification criteria are critical to advancing research and clinical care. A collaborative effort by EULAR and ACR was undertaken to generate candidate criteria, and then to reduce them to a smaller set. The objective of the current study was to select a set of criteria that maximizes the likelihood of accurate classification of SLE, particularly early disease. Read More

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http://dx.doi.org/10.3899/jrheum.180478DOI Listing
December 2018
5 Reads

Coexistence of Systemic Lupus Erythematosus and Myasthenia Gravis: An Unusual Case of Polyautoimmunity.

Reumatol Clin 2018 Dec 3. Epub 2018 Dec 3.

Unidad de Reumatología, Hospital Universitario San Ignacio, Bogotá, Colombia.

The relevance of polyautoimmunity, defined as the presence of 2or more autoimmune diseases in the same individual, is one of the issues not yet elucidated in medical practice. The coexistence of myasthenia gravis (MG) and systemic lupus erythematosus (SLE) is a clinical challenge due to the possible differential diagnoses of muscle involvement in patients with SLE. We present the case of a patient who came to the emergency room of Hospital Universitario San Ignacio in Bogotá, Colombia, with a previous diagnosis of SLE, who developed acute weakness in the context of a systemic infection, with a clinical and electrophysiological diagnosis of MG. Read More

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http://dx.doi.org/10.1016/j.reuma.2018.08.013DOI Listing
December 2018
2 Reads

Infectious and Noninfectious Acute Pericarditis in Children: An 11-Year Experience.

Int J Pediatr 2018 8;2018:5450697. Epub 2018 Nov 8.

Division of Infectious Diseases, Children's Hospital of Michigan, Detroit, MI, USA.

Objective: The study was undertaken to determine the etiology, review management, and outcome in children diagnosed with acute pericarditis during 11 years at tertiary pediatric institution.

Methods: Retrospective chart review of children diagnosed between 2004 and 2014. Patients with postsurgical pericardial effusions were excluded. Read More

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https://www.hindawi.com/journals/ijpedi/2018/5450697/
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http://dx.doi.org/10.1155/2018/5450697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250032PMC
November 2018
15 Reads

Difficult-to-diagnose diabetes in a patient treated with cyclophosphamide - the contradictory roles of immunosuppressant agents: a case report.

J Med Case Rep 2018 Dec 10;12(1):364. Epub 2018 Dec 10.

Unidad de Investigación Médica en Endocrinología Experimental, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauhtémoc 330, Colonia Doctores, 06720, Mexico City, Mexico.

Background: Cyclophosphamide may induce autoimmune diabetes through a decrease in suppressor T cells and increase of proinflammatory T helper type 1 response in animal models. In humans, this association is not as clear due to the presence of other risk factors for hyperglycemia, but it could be a precipitant for acute complications.

Case Presentation: A 31-year-old Mestizo-Mexican woman with a history of systemic lupus erythematosus presented with severe diabetic ketoacidosis, shortly after initiating a multi-drug immunosuppressive therapy. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1925-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287356PMC
December 2018
4 Reads

Ischemic stroke as initial manifestation of systemic lupus erythematosus: A case report and review of the literature.

eNeurologicalSci 2018 Dec 9;13:26-30. Epub 2018 Nov 9.

Department of Neurology, University Hospital of Heraklion, University of Crete, Greece.

Stroke is a frequent occurrence among patients suffering from systemic lupus erythematosus (SLE), but it rarely occurs as the initial manifestation of the disease. We here present the case of a 37 year-old patient who developed an acute cerebellar ischemic stroke as initial event of SLE: elevated partial thromboplastin time and ESR, thrombocytopenia, anti-ds-DNA, anti-SSA, anti-JO-1, and the lupus anticoagulant were detected, and the diagnosis of SLE was established. In addition, we reviewed the literature in order to clarify the demographic, clinical, imaging and outcome characteristics of such a presentation, and found 10 similar cases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24056502183003
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http://dx.doi.org/10.1016/j.ensci.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251781PMC
December 2018
7 Reads

Lamotrigine-induced Systemic Lupus Erythematosus: A Diagnostic Dilemma.

Indian Dermatol Online J 2018 Nov-Dec;9(6):445-447

Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Many drugs are known to cause systemic lupus erythematosus (SLE), however there are no well defined criteria for drug induced lupus erythematosus (DILE). We present a rare case of lamotrigine induced lupus presenting as acute syndrome of apoptotic pan epidermolysis (ASAP). Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_24_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232978PMC
December 2018
1 Read

Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus.

J Psychopharmacol 2018 Nov 28:269881118812102. Epub 2018 Nov 28.

3 Bristol-Myers Squibb India Pvt. Ltd., Bangalore, India.

Background:: A significant proportion of patients suffering from major depression fail to remit following treatment and develop treatment-resistant depression. Developing novel treatments requires animal models with good predictive validity. MRL/lpr mice, an established model of systemic lupus erythematosus, show depression-like behavior. Read More

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http://dx.doi.org/10.1177/0269881118812102DOI Listing
November 2018
7 Reads
3.593 Impact Factor

Subacute cerebellar ataxia as presenting symptom of systemic lupus erythematosus.

Eur Rev Med Pharmacol Sci 2018 Nov;22(21):7401-7403

IRCCS "NEUROMED", Pozzilli, Isernia,

Neuropsychiatric manifestations are commonly observed in systemic lupus erythematosus (SLE) patients. In particular, neurological involvement is known to be more common in patients with positive anticardiolipin antibodies and lupus anticoagulants. Nevertheless, cerebellar ataxia has rarely been reported, especially as the first clinical manifestation of this systemic autoimmune disorder. Read More

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http://dx.doi.org/10.26355/eurrev_201811_16279DOI Listing
November 2018
15 Reads

Study of Antiphospholipid Antibodies in Patients with Arterial Hypertension.

Med Sci (Basel) 2018 Nov 13;6(4). Epub 2018 Nov 13.

Laboratory of Microbiology, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana Campus, 68100 Alexandroupolis, Greece.

Antiphospholipid syndrome (APS) is a multifactorial, autoantibody-mediated disease. Antiphospholipid antibodies (aPL) directed against negatively charged phospholipids or various combinations of phospholipid-binding proteins seem to be an independent pathogenic factor that plays a critical role in APS. Unfortunately, their role in hypertension is not fully elucidated. Read More

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http://dx.doi.org/10.3390/medsci6040102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313595PMC
November 2018
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Acute Myocardial Infarction Outcomes in Systemic Lupus Erythematosus (from the Nationwide Inpatient Sample).

Am J Cardiol 2019 Jan 19;123(2):227-232. Epub 2018 Oct 19.

Division of Cardiology, Wayne State University/Detroit Medical Center, Detroit, Michigan.

One of the major causes of mortality in systemic lupus erythematosus (SLE) is acute myocardial infarction. Whether in-hospital outcomes and management of ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) are different in SLE patients compared with those without SLE from large, recent dataset is unclear. We queried the Nationwide Inpatient Database from 2005 to 2014 and identified STEMI and NSTEMI admissions with and without SLE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183197
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http://dx.doi.org/10.1016/j.amjcard.2018.09.043DOI Listing
January 2019
9 Reads

Bilateral central retinal artery occlusion from catastrophic antiphospholipid syndrome.

BMJ Case Rep 2018 Nov 12;2018. Epub 2018 Nov 12.

Department of Internal Medicine, John H Stroger Jr Hospital of Cook County, Chicago, Illinois, USA.

A 23-year-old woman with history of systemic lupus erythematous presented with dizziness and headache and was admitted for the stroke workup. During her stay, she had sudden painless loss of vision in her right eye consistent with central retinal artery occlusion (CRAO). Ocular massage and paracentesis were attempted without success to resume the flow. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22646
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http://dx.doi.org/10.1136/bcr-2018-226463DOI Listing
November 2018
17 Reads

Pulmonary involvement in neonatal lupus: a challenging diagnosis - case report and literature review.

Acta Reumatol Port 2018 Jul-Sep;43(3):230-234

Neonatal Intensive Care Unit.

Introduction: Pulmonary involvement is relatively frequent in adult and juvenile patients with Systemic Lupus Erythematosus (SLE), but its occurrence in newborns with Neonatal Lupus Erythematosus (NLE) is exceedingly rare.

Case Report: A mother with SLE and positive anti-SSA/Ro and anti-SSB/La delivered a preterm newborn with third-degree heart block and positive anti-SSA/Ro confirmed postnatally. A temporary pacemaker was placed at D3 and a definitive pacemaker only at D15 due to sepsis with concurrent mild respiratory failure. Read More

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November 2018
4 Reads