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    Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus.
    JCI Insight 2018 Apr 19;3(8). Epub 2018 Apr 19.
    National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and.
    Background: Systemic lupus erythematosus (SLE) is associated with enhanced risk of atherosclerotic cardiovascular disease not explained by Framingham risk score (FRS). Immune dysregulation associated to a distinct subset of lupus proinflammatory neutrophils (low density granulocytes; LDGs) may play key roles in conferring enhanced CV risk. This study assessed if lupus LDGs are associated with in vivo vascular dysfunction and inflammation and coronary plaque. Read More

    Rare case of chorea-hyperglycaemia-basal ganglia (C-H-BG) syndrome.
    BMJ Case Rep 2018 Apr 17;2018. Epub 2018 Apr 17.
    Department of Diabetes and Endocrinology, University Hospital Llandough, Llandough, UK.
    An 83-year-old woman presented with acute-onset haemichorea and haemiballism particularly affecting the left side of the body. She was known to have type 2 diabetes, which was poorly controlled with sitagliptin. She was hyperglycaemic but not ketotic or acidotic. Read More

    Rapidly progressive glomerulonephritis: A wild card manifestation of lupus nephritis.
    Saudi J Kidney Dis Transpl 2018 Mar-Apr;29(2):443-451
    Renal Unit, Abuja Clinics, Abuja, Nigeria.
    A significant proportion of individuals with systemic lupus erythematosus (SLE) will have clinical or laboratory evidence of renal involvement at some point in the course of their disease. Lupus nephritis (LN) is one of the more important systemic manifestations of SLE and although progression to end-stage renal disease (ESRD) is not usually the norm, a significant minority of patients will do so, some in a rather dramatic fashion. It is in such instances that LN constitutes a true nephrologic emergency. Read More

    Acute gastric dilatation in a patient with lupus nephritis: An uncommon presentation of lupus mesenteric vasculitis.
    Saudi J Kidney Dis Transpl 2018 Mar-Apr;29(2):429-434
    Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Abdominal symptoms are common in patients with lupus nephritis and are often attributed to drugs or uremia per se. Lupus mesenteric vasculitis (LMV) or lupus enteritis is a rare entity reported in patients with active systemic lupus erythematosus. It usually occurs in patients with a long-standing history of lupus with high disease activity. Read More

    Steroid-Induced Psychosis in the Pediatric Population: A New Case and Review of the Literature.
    J Child Adolesc Psychopharmacol 2018 Apr 11. Epub 2018 Apr 11.
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine , Miami, Florida.
    Objectives: Iatrogenic steroid-induced psychosis is a rare but serious adverse side effect seen largely in the adult population that less commonly affects children and adolescents. Given the significant distress steroid-induced psychosis may cause, recommendations are needed for effective management. Here we conducted a systematic review of the literature and report a new case of steroid-induced psychosis in a 12-year-old patient. Read More

    Natural history of longitudinally extensive transverse myelitis in 35 Hispanic patients with systemic lupus erythematosus: good short-term functional outcome and paradoxical increase in long-term mortality.
    Lupus 2018 Jan 1:961203318770015. Epub 2018 Jan 1.
    1 Department of Neurology, 42559 Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City, Mexico.
    Background and objective Acute transverse myelitis (TM) is an infrequent neurological complication of systemic lupus erythematosus (SLE). Short-term outcome varies widely between cohorts. Little is known about the epidemiology and long-term functional outcome of TM associated to SLE. Read More

    Acute glomerulonephritis with large confluent IgA-dominant deposits associated with liver cirrhosis.
    PLoS One 2018 10;13(4):e0193274. Epub 2018 Apr 10.
    Department of Pathology, Division of Renal and Transplant Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.
    Background: Small glomerular IgA deposits have been reported in patients with liver cirrhosis, mainly as an incidental finding in autopsy studies. We recently encountered nine cirrhotic patients who presented with acute proliferative glomerulonephritis with unusually large, exuberant glomerular immune complex deposits, in the absence of systemic lupus erythematosus (SLE) or monoclonal gammopathy-related kidney disease. Deposits were typically IgA dominant/codominant. Read More

    Rhabdomyolysis secondary to systemic lupus erythematosus.
    Auto Immun Highlights 2018 Apr 6;9(1). Epub 2018 Apr 6.
    Texas Tech University Health Sciences Center Amarillo School of Medicine, 1400 S Coulter St, Amarillo, TX, 79106, USA.
    Systemic lupus erythematous (SLE) is a systemic auto-immune disorder with a variety of presentations and wide spread organ involvement. We present a case report of a patient with an SLE exacerbation as well as concurrent rhabdomyolysis with massively elevated CPK (304,700 U/L). Though a rarely reported effect of SLE, rhabdomyolysis can be severe and potentially lethal secondary or concurrent to an acute SLE episode. Read More

    Hepatic Rupture Induced by Spontaneous Intrahepatic Hematoma.
    Case Rep Surg 2018 28;2018:2026846. Epub 2018 Jan 28.
    Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, China.
    The etiology of hepatic rupture is usually secondary to trauma, and hepatic rupture induced by spontaneous intrahepatic hematoma is clinically rare. We describe here a 61-year-old female patient who was transferred to our hospital with hepatic rupture induced by spontaneous intrahepatic hematoma. The patient had no history of trauma and had a history of systemic lupus erythematosus for five years, taking a daily dose of 5 mg prednisone for treatment. Read More

    Chorea revealing systemic lupus erythematosus in a 13-year old boy: A case report and short review of the literature.
    Int Rev Immunol 2018 Mar 29:1-6. Epub 2018 Mar 29.
    a Department of Paediatrics , Venizeleion General Hospital , Heraklion, Crete , Greece.
    Among the neurological manifestations of systemic lupus erythematosus (SLE), chorea is rare, presenting in less than 7% of the pediatric SLE patients. It can appear early in the onset of SLE, be the first or even the sole clinical feature of the illness and has strongly been associated with the presence of antiphospholipid antibodies. We report on the case of a 13-year old boy, admitted with acute onset chorea and finally diagnosed with SLE. Read More

    [Life threatening manifestations of lupus and antiphospholipid syndrome in internal medicine].
    Vnitr Lek 2018 ;64(2):136-145
    The clinical picture of systemic lupus and antiphospholipid syndrome is remarkably varied and disease manifestations are commonly very heterogeneous. Relatively often both diseases are associated with severe, acute and life threatening manifestations, which places demands on the knowledge of differential diagnostics and experience of the physicians. This article deals with the serious and mostly acute impairment of cardiovascular, respiratory, renal, gastrointestinal, hematopoietic or nervous systems, briefly discusses the acute pregnancy complication and summarizes the basic therapeutic option. Read More

    Isolated acute lupus pneumonitis as the initial presentation of systemic lupus erythematosus in an 8-year-old girl.
    Auto Immun Highlights 2018 Mar 27;9(1). Epub 2018 Mar 27.
    Department of Radiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which has broad pleuropulmonary manifestations. One of the rare and mortal complications is acute lupus pneumonitis, which is reported very rarely, especially in childhood. Herein, we report an 8-year-old girl with isolated acute lupus pneumonitis as the initial presentation that required a lung biopsy for diagnosis. Read More

    Fevers in Adult Lupus Patients.
    Cureus 2018 Jan 22;10(1):e2098. Epub 2018 Jan 22.
    Division of Rheumatology, The Johns Hopkins University School of Medicine.
    Variability in systemic lupus erythematosus (SLE) disease manifestations is well recognized. Lupus disease activity can range from mild to severe. Fever is a common manifestation of SLE and occurs in 36%-86% of patients. Read More

    Acute diffuse alveolar haemorrhage accompanied by gastrointestinal bleeding in a patient with serious systemic lupus erythematosus: A case report.
    J Int Med Res 2018 Jan 1:300060517749666. Epub 2018 Jan 1.
    4 Department of Rheumatology and Immunology, 74678 Zhejiang Provincial People's Hospital , People's Hospital of Hangzhou Medical College, Hangzhou, China.
    Systemic lupus erythematosus (SLE) is an autoimmune disease that affects many organs, but multisystem dysfunction is rare. Here, we report a case of a 29-year-old woman who was initially diagnosed with SLE complications including lupus nephritis, lupus encephalopathy, renal hypertension, thrombocytopenia, anaemia and hyperkalaemia. She recovered following treatment with high dose methylprednisolone, intravenous immunoglobulin (IVIG) and continuous renal replacement therapy (CRRT). Read More

    A case of duodenal malignant lymphoma presenting as acute pancreatitis: systemic lupus erythematosus and immunosuppressive therapy as risk factors.
    Clin J Gastroenterol 2018 Mar 15. Epub 2018 Mar 15.
    Department of Gastroenterology and Hepatology, Mie University Hospital, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
    A 49-year-old man was admitted to our hospital with pancreatitis. He was diagnosed with systemic lupus erythematosus at 34 years of age and was being treated with oral tacrolimus (3 mg/day) and predonine (10 mg/day) for the past 15 months. The computed tomography (CT) scan showed the mass lesion had invaded the pancreatic head via thickening of the duodenal wall. Read More

    Urinary neutrophil gelatinase-associated lipocalin as a marker for disease activity in lupus nephritis.
    Scand J Clin Lab Invest 2018 Mar 13:1-5. Epub 2018 Mar 13.
    d Department of Clinical Pathology , AL-Azhar University , Assiut , Egypt.
    The neutrophil gelatinase-associated lipocalin (NGAL) has been emerging as a novel biomarker of acute kidney injury while its value in lupus nephritis is uncertain. The aim of this study was to assess urinary NGAL levels as a marker for disease activity in patients with lupus nephritis.This study included 70 systemic lupus erythematosus (SLE) patients; 50 with active lupus nephritis (LN) and 20 without as well as 20 matched controls. Read More

    Fatal visceral disseminated varicella zoster infection during initial remission induction therapy in a patient with lupus nephritis and rheumatoid arthritis-possible association with mycophenolate mofetil and high-dose glucocorticoid therapy: a case report.
    BMC Res Notes 2018 Mar 5;11(1):165. Epub 2018 Mar 5.
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 951-8510, Japan.
    Background: Visceral disseminated varicella zoster viral (VZV) infection is a rare but severe complication with a high mortality rate in immunosuppressed individuals, and an increased susceptibility to VZV has been reported in kidney transplant recipients who are treated with mycophenolate mofetil (MMF). In Japan, MMF is currently approved for patients with lupus nephritis (LN) and data to indicate its optimal dosage are still insufficient.

    Case Presentation: A 46-year-old Japanese woman with rheumatoid arthritis was diagnosed as having systemic lupus erythematosus (SLE) and LN class III (A/C). Read More

    Anti-Epstein-Barr virus antibodies in Beijing during 2013-2017: What we have found in the different patients.
    PLoS One 2018 1;13(3):e0193171. Epub 2018 Mar 1.
    Department of Clinical Laboratories, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Background: Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC) which is prevalent in South China, and its association with systemic lupus erythematosus (SLE) or other autoimmune diseases has not been studied in the mainland of China. The EBV serological tests have been performed on patients with various diseases or manifestations for years at our institution and their values need to be evaluated.

    Methods: For routine medical purposes, anti-EB viral capsid antigen (VCA) IgG, IgA and IgM antibodies, anti-EBV diffuse early antigen (EA-D) IgA antibodies, and anti-EBV nuclear antigen-1(EBNA-1) IgG antibodies were tested with commercial enzyme-linked immunosorbent assay (ELISA) in patients visiting Peking Union Medical College Hospital between 2013 and 2017. Read More

    [Lupus enteritis as initial manifestation of systemic lupus erythematosus. Report of one case].
    Rev Med Chil 2017 Oct;145(10):1349-1352
    Clínica Universidad de los Andes, Santiago, Chile.
    Although gastrointestinal symptoms are not rare in Systemic lupus erythematosus, enteritis is an atypical manifestation of the disease. We report a 54 year-old woman who presented acute symptoms of diarrhea, fever and abdominal pain, receiving empiric antibiotic therapy for bacterial enteritis with no response. Computed tomography showed diffuse small intestine inflammation and serositis. Read More

    Thrombotic thrombocytopenic purpura in the course of systemic lupus erythematosus in a 15-year-old girl.
    Cent Eur J Immunol 2017 30;42(4):407-408. Epub 2017 Dec 30.
    Department of Pediatrics and Nephrology, Medical University of Warsaw, Poland.
    Systemic lupus erythematosus (SLE) concomitant with thrombotic thrombocytopenic purpura (TTP) in children is rarely diagnosed. We report a case of a 15-year-old girl with butterfly patch, generalized edema, leg pain, anemia (Hb 74 g/l), thrombocytopenia (5 x 10/l), schistocytes in peripheral blood smear, acute kidney injury (eGFR 27 ml/min/1.73 m), proteinuria, and erythrocyturia. Read More

    Unique urticarial presentation of minocycline-induced lupus erythematosus.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Department of Dermatology, University of California, Davis, Sacramento, CA USA, Department of Biological Sciences, California State Univeristy, Sacramento, CA USA.
    The association between guttate psoriasis and infection with group A Streptococcus (GAS) has been well established in the medical literature. However, responses to treatments aimed at GAS eradication such as systemic antibiotics or tonsillectomy are inconsistent. Further complicating treatment recommendations for a disease with a suspected microbial trigger, the standard therapy for severe psoriasis is with systemic immunosuppressant medications. Read More

    Haemolytic-uremic syndrome due to infection with adenovirus: A case report and literature review.
    Medicine (Baltimore) 2018 Feb;97(7):e9895
    Lucian Blaga University of Sibiu, Faculty of Medicine Sibiu, Romania.
    Rationale: Haemolytic-uremic syndrome is a rare but serious complication of bacterial and viral infections, which is characterized by the triad of: acute renal failure, microangiopathic haemolytic anemia and thrombocytopenia, sometimes severe, requiring peritoneal dialysis. In Europe, hemolytic-uremic syndrome (HUS) in paediatric pathology is primarily caused by Shiga toxin-producing Escherichia coli (STEC) O157, followed by O26. Beside these etiologies, there are other bacterial and viral infections, and also noninfectious ones that have been associated to lead to HUS as well: in the progression of neoplasia, medication-related, post-transplantation, during pregnancy or associated with the antiphospholipid syndrome, systemic lupus erythematosus or family causes with autosomal dominant or recessive inheritance. Read More

    Drug-induced Rowell syndrome, a rare and difficult to manage disease: A case report.
    Exp Ther Med 2018 Jan 23;15(1):785-788. Epub 2017 Nov 23.
    Department of Ophthalmology, Grigore T. Popa University of Medicine and Pharmacy, 700715 Iași, Romania.
    Rowell syndrome is defined as the association between lupus erythematosus, erythema multiforme-like lesions and characteristic immunological changes including positive tests for rheumatoid factor, speckled antinuclear antibody, positive anti-Ro or anti-La antibodies. The present report presents the case of a 45-year-old female patient who was previously diagnosed in January 2010 with terbinafine-induced subacute cutaneous lupus erythematosus and was admitted for a skin eruption consisting of erythematous-papular erythema multiforme-like lesions, primarily on the trunk and limbs. The associated symptoms consisted of fatigability, myalgia and gonalgia. Read More

    Bioactive Lipids and Chronic Inflammation: Managing the Fire Within.
    Front Immunol 2018 29;9:38. Epub 2018 Jan 29.
    Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
    Inflammation is an immune response that works as a contained fire that is pre-emptively sparked as a defensive process during infections or upon any kind of tissue insult, and that is spontaneously extinguished after elimination or termination of the damage. However, persistent and uncontrolled immune reactions act as a wildfire that promote chronic inflammation, unresolved tissue damage and, eventually, chronic diseases. A wide network of soluble mediators, among which endogenous bioactive lipids, governs all immune processes. Read More

    Ten-year retrospective clinicohistological study of cutaneous lupus erythematosus in Korea.
    J Dermatol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Dermatology, College of Medicine, University of Hanyang, Seoul, Korea.
    An understanding of the differences in clinical manifestations and laboratory abnormalities between subtypes of cutaneous lupus erythematosus (CLE) is still lacking. The purpose of this study was to analyze demographic, clinical and histological features of CLE according to three main presentation subsets: acute (ACLE), subacute (SCLE) and chronic (CCLE). A 10-year retrospective analysis was performed on data from patients who were diagnosed with CLE between March 2005 and September 2015 in a Korean tertiary referral dermatology clinic. Read More

    Causes and predictors of mortality in biopsy-proven lupus nephritis: the Sarawak experience.
    Clin Kidney J 2018 Feb 17;11(1):56-61. Epub 2017 Jul 17.
    Nephrology Unit, Department of Medicine, Sarawak General Hospital, Sarawak, Malaysia.
    Background: Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus that can be fatal if left untreated. The causes and prognostic predictors of mortality in LN have been well studied in developed countries but evidence is lacking for developing countries. The objective of this study was to investigate the causes and predictors of mortality in a cohort of Malaysian patients with biopsy-proven LN. Read More

    Gastrointestinal Manifestations of Autoimmune Diseases Requiring Critical Care.
    Crit Care Nurs Clin North Am 2018 Mar 6;30(1):1-12. Epub 2017 Dec 6.
    Capstone College of Nursing, The University of Alabama, Box 870358, Tuscaloosa, AL 35487, USA; Sacred Heart of Pensacola, Pensacola, FL, USA. Electronic address:
    Proper functioning within the gastrointestinal (GI) system is essential to immune integrity. Autoimmune diseases (ADs) can disrupt GI integrity and cause serious derangements of organ function. ADs exist on a continuum of mild to severe. Read More

    Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report.
    Medicine (Baltimore) 2018 Feb;97(5):e9794
    Division of Rheumatology/Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital.
    Rationale: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, spiking fever, arthralgia/ arthritis, and lymphadenopathy. AOSD sometimes was fatal when it is complicated by macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH). Nonetheless, the literature provides no recommendations for treatment of AOSD patients with severe sepsis. Read More

    Evaluation and Management of Spinal Subarachnoid Hemorrhage in a Patient with Lupus Vasculitis.
    Am J Case Rep 2018 Jan 31;19:114-117. Epub 2018 Jan 31.
    Department of Neurology, Advocate Christ Medical Center, Oak Lawn, IL, USA.
    BACKGROUND Isolated spinal artery subarachnoid hemorrhage is a rare occurrence in the general population, but occurs more commonly as one of many neurologic sequela of systemic lupus erythematosus (SLE). The etiology of a neurologic deficit in an SLE patient is often multifactorial. Comorbid conditions, such as antiphospholipid antibody syndrome, predispose to stroke. Read More

    Cutaneous lupus erythematosus: clinico-pathologic correlation.
    G Ital Dermatol Venereol 2018 Apr 24;153(2):216-229. Epub 2018 Jan 24.
    Unit of Dermatology, "A. Perrino" Hospital, Brindisi, Italy.
    Cutaneous lupus erythematosus (CLE) is a chronic-relapsing disease. It is defined as a LE localized to the skin without any significant systemic symptoms. Its annual incidence is of 4 cases per 100,000 persons with a prevalence of 73 cases per 100,000 persons. Read More

    Performance of the 2012 Systemic Lupus International Collaborating Clinics classification criteria versus the 1997 American College of Rheumatology classification criteria in adult and juvenile systemic lupus erythematosus. A systematic review and meta-analysis.
    Autoimmun Rev 2018 Mar 31;17(3):316-322. Epub 2018 Jan 31.
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; 1st Medical Department & Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Hanusch Hospital, Vienna, Austria; Sigmund Freud University, Vienna, Austria. Electronic address:
    Objective: To evaluate the performance in classifying systemic lupus erythematosus by the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC'12), versus the revised American College of Rheumatology criteria from 1997 (ACR'97) in adult and juvenile SLE patients.

    Methods: A systematic literature search was conducted in PubMed and Embase for studies comparing SLICC'12 and ACR'97 with clinical diagnosis. A meta-analysis was performed to estimate the sensitivity and specificity of SLICC'12 and ACR'97. Read More

    [Renal Involvement in Connective Tissue Diseases].
    Dtsch Med Wochenschr 2018 Jan 22;143(2):89-100. Epub 2018 Jan 22.
    Renal involvement is common and heterogenous in connective tissue diseases and has a main influence on prognosis and mortality. In systemic lupus erythematosus proliferative glomerulonephritis is the most common manifestation, while in primary Sjogren's syndrome interstitial nephritis with tubular dysfunction is the predominant pathological feature. In systemic sclerosis the most serious renal manifestation is scleroderma renal crisis characterized by abrupt onset of hypertension and acute kidney injury associated with an increase in plasma renin activity. Read More

    ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus.
    J Bras Nefrol 2017 Oct-Dec;39(4):454-457
    Laboratorios Integrados S.A, Lima, Perú.
    The pauci-immune crescentic glomerulonephritis (PICGN) is generally associated with small-vessel vasculitis with a few reported cases associated with other autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We present the case of a female 34-year-old patient with acute kidney injury symptoms with indication for renal replacement therapy in the context of clinical SLE diagnosis. A kidney biopsy was conducted and it was found that most glomeruli showed some segmental sclerosis with synechia to the Bowman's capsule. Read More

    Proliferative lupus nephritis in the absence of overt systemic lupus erythematosus: A historical study of 12 adult patients.
    Medicine (Baltimore) 2017 Dec;96(48):e9017
    Service de néphrologie, CHU Bichat, AP-HP, INSERM U1199, Paris Diderot University and DHU FIRE, Paris, France.
    Severe lupus nephritis in the absence of systemic lupus erythematosus (SLE) is a rare condition with an unclear clinical presentation and outcome.We conducted a historical observational study of 12 adult (age >18 years) patients with biopsy-proven severe lupus nephritis or lupus-like nephritis without SLE immunological markers at diagnosis or during follow-up. Excluded were patients with chronic infections with HIV or hepatitis B or C; patients with a bacterial infectious disease; and patients with pure membranous nephropathy. Read More

    Vertebrobasilar Artery Stroke as the Heralding Sign of Systemic Lupus Erythematosus.
    J Stroke Cerebrovasc Dis 2018 May 3;27(5):e80-e85. Epub 2018 Jan 3.
    Department of Anesthesiology, SUNY-Buffalo, Buffalo, New York. Electronic address:
    Cerebral ischemia because of vertebrobasilar insufficiency (VBI) rarely presents as an initial sign within the systemic lupus erythematosus (SLE) population, and there are very few case reports supporting this manifestation. This report details 3 different patients with SLE who experienced VBI as an initial manifestation. Patient 1 was a 24-year-old female who developed a bilateral pontine lesion as a consequence of basilar artery stenosis. Read More

    Colonic perforation due to severe cytomegalovirus disease in granulomatosis with polyangiitis after immunosuppression.
    Clin Rheumatol 2018 Jan 4. Epub 2018 Jan 4.
    Rheumatology Unit, Department of Internal Medicine, Arcispedale Santa Maria Nuova, Azienda USL di Reggio Emilia - IRCCS, Viale Risorgimento 80, 42122, Reggio Emilia, Italy.
    Granulomatosis with polyangiitis (GPA) is a small-vessel necrotizing granulomatous vasculitis typically involving upper airways, lungs, and kidneys, which may lead to end-organ damage and life-threatening complications. Major infections during GPA course represent a considerable concern in the management of the disease. Cytomegalovirus (CMV) infection and disease are rare but significant complications in the course of GPA being associated with high morbidity and mortality rates. Read More

    Clinical features and prognoses of acute transverse myelitis in patients with systemic lupus erythematosus.
    Korean J Intern Med 2018 Jan 5. Epub 2018 Jan 5.
    Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Background/aims: Acute transverse myelitis (ATM) is a severe complication of systemic lupus erythematosus (SLE). This study evaluated the clinical factors related to outcome in patients with SLE-associated ATM.

    Methods: The medical records of patients diagnosed with SLE-associated ATM between January 1995 and January 2015 were reviewed. Read More

    Differential serum cytokine profile in patients with systemic lupus erythematosus and posterior reversible encephalopathy syndrome.
    Clin Exp Immunol 2018 May 16;192(2):165-170. Epub 2018 Jan 16.
    Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
    Systemic lupus erythematosus (SLE) patients are susceptible to the development of posterior reversible encephalopathy syndrome (PRES). The main theory concerning the physiopathology of PRES suggests that there is brain-blood barrier damage, which is associated with endothelial dysfunction, and characterized by vasogenic oedema. However, current evidence regarding its physiopathogenic mechanisms is quite scant. Read More

    Lupus podocytopathy: a distinct entity of lupus nephritis.
    J Nephrol 2017 Dec 22. Epub 2017 Dec 22.
    National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, 210016, Jiangsu, China.
    Systemic lupus erythematosus (SLE) patients clinically presenting with nephrotic syndrome demonstrating minimal change disease (MCD), mesangial proliferation (MsP) or focal segmental glomerulosclerosis (FSGS), while on electronic microscopy, diffuse podocyte foot process effacement in absence of sub-epithelial or sub-endothelial deposition is the only morphological feature and now diagnosed as lupus podocytopathy. Lupus podocytopathy with glomerular morphology of MCD or MsP usually presents with typical nephrotic syndrome and sensitive to glucocorticoid treatment, but the relapse rate could reach up to 90% on maintenance treatment with glucocorticoid alone. Glucocorticoid plus other immunosuppressive agents could significantly decrease the relapse rate. Read More

    T cell subsets and immunoglobulin G levels are associated with the infection status of systemic lupus erythematosus patients.
    Braz J Med Biol Res 2017 Dec 11;51(2):e4547. Epub 2017 Dec 11.
    Department of Rheumatology, Tianjin Medical University General Hospital, Tianjin, China.
    Systemic lupus erythematosus (SLE) is a chronic, autoimmune disorder that affects nearly all organs and tissues. As knowledge about the mechanism of SLE has increased, some immunosuppressive agents have become routinely used in clinical care, and infections have become one of the direct causes of mortality in SLE patients. To identify the risk factors indicative of infection in SLE patients, a case control study of our hospital's medical records between 2011 and 2013 was performed. Read More

    Efficacy of Rituximab in a Systemic Lupus Erythematosus Patient Presenting with Diffuse Alveolar Hemorrhage.
    Case Rep Rheumatol 2017 15;2017:6031053. Epub 2017 Nov 15.
    Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR, USA.
    Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of systemic lupus erythematosus (SLE). Although infrequent, its mortality is very high. While there are no established therapeutic guidelines, DAH has been traditionally managed with high-dose intravenous (IV) corticosteroids, cyclophosphamide, and plasma exchange. Read More

    Systemic lupus erythematosus and ocular involvement: an overview.
    Clin Exp Med 2017 Dec 14. Epub 2017 Dec 14.
    Department of Basic Medical Sciences, Neurosciences and Sensory Organ, University of Bari Medical School, Clinica Oculistica, Policlinico, Piazza Giulio Cesare, 70124, Bari, Italy.
    Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease of undefined etiology and with remarkably heterogeneous clinical features. Virtually any organ system can be affected, including the eye. SLE-related eye involvement can be diagnosed in approximately one-third of the patients and is usually indicative of disease activity. Read More

    Neuropsychiatric manifestations are not uncommon in Indian lupus patients and negatively affect quality of life.
    Lupus 2018 Apr 14;27(4):688-693. Epub 2017 Dec 14.
    1 Department of Internal Medicine, 29751 Postgraduate Institute of Medical Education and Research , Chandigarh, India.
    Objectives The objectives of this paper are to look at the prevalence of neuropsychiatric manifestations and assess their impact on quality of life in North Indian lupus patients. Methods The study included consecutive patients with systemic lupus erythematosus (SLE) who were older than 18 years and met the SLICC 2012 criteria. A diagnosis of a neuropsychiatric syndrome was made as per ACR 1999 definitions. Read More

    High-dose intravenous immunoglobulins for the treatment of dermatological autoimmune diseases.
    J Dtsch Dermatol Ges 2017 Dec;15(12):1211-1226
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
    Based on their immunomodulatory properties, high-dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second- or third-line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second-line therapy after failure of corticosteroid monotherapy. Read More

    Regulation of Neuroinflammation: What Role for the Tumor Necrosis Factor-Like Weak Inducer of Apoptosis/Fn14 Pathway?
    Front Immunol 2017 16;8:1534. Epub 2017 Nov 16.
    Aix-Marseille University, CNRS, NICN, Marseille, France.
    Observed in many central nervous system diseases, neuroinflammation (NI) proceeds from peripheral immune cell infiltration into the parenchyma, from cytokine secretion and from oxidative stress. Astrocytes and microglia also get activated and proliferate. NI manifestations and consequences depend on its context and on the acute or chronic aspect of the disease. Read More

    High Health Care Utilization Preceding Diagnosis of Systemic Lupus Erythematosus in Youth.
    Arthritis Care Res (Hoboken) 2017 Dec 1. Epub 2017 Dec 1.
    Center for Pediatric Clinical Effectiveness & PolicyLab, The Children's Hospital of Philadelphia.
    Objective: Childhood-onset systemic lupus erythematosus (SLE) is associated with high risk for organ damage, which may be mitigated by early diagnosis and treatment. We characterized health care utilization for youth in the year preceding SLE diagnosis compared to controls.

    Methods: Using Clinformatics DataMart (OptumInsight, Eden Prairie, MN) de-identified administrative data from 2000 to 2013, we identified 682 youth ages 10-24 years with new-onset SLE (≥3 International Classification of Diseases, Ninth Revision (ICD-9) codes for SLE 710. Read More

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