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    Effects of Arsenic Trioxide on INF-gamma Gene Expression in MRL/lpr Mice and Human Lupus.
    Biol Trace Elem Res 2017 Nov 20. Epub 2017 Nov 20.
    Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Nan Bai Xiang Street, Ouhai District, Wenzhou, Zhejiang Province, 325000, China.
    Arsenic trioxide (As2O3; ATO), a traditional Chinese medicine, is used to treat patients with acute promye-locytic leukemia, while its application for treatment of systemic lupus erythematosus (SLE) is still under evaluation. The high expression of INF-gamma (INF-γ) is a primary pathogenic factor in SLE. It is found that ATO can reduce INF-γ expression levels in lupus-prone mice, whereas it is not clear whether ATO has the same effect on SLE patients. Read More

    TNF Antagonists: Killing Two "Birds" with one Biologic "Stone".
    Arthritis Rheumatol 2017 Nov 16. Epub 2017 Nov 16.
    Division of Rheumatology, Department of Medicine of the Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Forty years have passed since it was first recognized that patients with autoimmune rheumatic disease have an increased risk of fatal and non-fatal cardiovascular (CV) events (1) Although initial reports focused on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), similar findings were verified subsequently in patients with psoriasis (Ps) and/or psoriatic arthritis (PsA) and spondyloarthritis. An early feature of the atherosclerotic lesion is infiltration with inflammatory cells, particularly monocytes/macrophages, and the presence of these cells in mature plaque elevates the risk of plaque rupture and thrombosis (2). In the general population, modest elevations of circulating inflammatory proteins, including C-reactive protein (CRP), interleukin-6 (IL-6) and soluble endothelial adhesion proteins, are associated with an increased risk of acute CV events (3). Read More

    Renal Macrophages and Dendritic Cells in SLE Nephritis.
    Curr Rheumatol Rep 2017 Nov 9;19(12):81. Epub 2017 Nov 9.
    Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York, NY, 11030, USA.
    Purpose Of Review: The purpose of the study was to review the characteristics of renal macrophages and dendritic cells during homeostasis and disease, with a particular focus on lupus nephritis.

    Recent Findings: Resident renal macrophages derive from embryonic sources and are long-lived and self-renewing; they are also replaced from the bone marrow with age. The unique characteristics of macrophages in each tissue are imposed by the microenvironment and reinforced by epigenetic modifications. Read More

    Intravenous thrombolysis in SLE-related stroke: a case report and literature review.
    Neurol Sci 2017 Nov 7. Epub 2017 Nov 7.
    Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, Jiangsu Province, 210002, China.
    Patients with systemic lupus erythematosus (SLE) bear an increased risk of ischemic stroke. However, evidences for treating acute stroke due to artery thrombosis in SLE patients are extremely limited. A 45-year-old woman experienced sudden left hemiplegia. Read More

    Clinical features, outcome, and associated factors for posterior reversible encephalopathy in Thai patients with systemic lupus erythematosus: a case-control study.
    Clin Rheumatol 2017 Nov 4. Epub 2017 Nov 4.
    Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
    Posterior reversible encephalopathy syndrome (PRES) in patients with systemic lupus erythematosus (SLE) has been recognized increasingly. This study aimed to determine the prevalence, clinical features, brain imaging findings, outcomes, and associated factors of PRES in Thai SLE patients. SLE patients with PRES were identified from the lupus cohort of Chiang Mai University. Read More

    Cardiovascular disease in patients with autoinflammatory syndromes.
    Rheumatol Int 2017 Nov 1. Epub 2017 Nov 1.
    Academic Research Unit, 2nd Department of Internal Medicine, Kepler University Hospital, Med Campus III, Krankenhausstr. 9, 4020, Linz, Austria.
    Autoinflammatory syndromes (AIS) are characterized by recurring events of inflammation, leading to a variety of organ manifestations and fever attacks. A subgroup of AIS is commonly referred to as hereditary periodic fever syndromes (HPFS). There is substantial evidence that autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are strongly associated with cardiovascular morbidity and mortality. Read More

    The involvement of galectin-3 in skin injury in systemic lupus erythematosus patients.
    Lupus 2017 Jan 1:961203317736144. Epub 2017 Jan 1.
    1 Department of Dermatology, 56713 Sun Yat-sen Memorial Hospital , Guangzhou, China.
    Objective Our previous research suggested that anti-galectin-3 antibody was highly associated with the development of lupus skin lesions in systemic lupus erythematosus (SLE). In this study we aimed to investigate the involvement of galectin-3 in SLE skin damage. Methods The study consisted of 49 patients with SLE, 16 with dermatomyositis and 11 with systemic scleroderma and 20 healthy controls. Read More

    [Different Symptoms and Course of Coronary Heart Disease in Men and Women].
    Dtsch Med Wochenschr 2017 Oct 18;142(21):1578-1584. Epub 2017 Oct 18.
    According to the federal statistical office, cardiovascular disorders are still the leading cause of death in Germany. Chronic ischemic heart disease and acute myocardial infarction are the most important subgroups. In addition to evidence-based and personalized medicine, in recent years gender medicine has been established as an independent research area. Read More

    The multifactorial origin of posterior reversible encephalopathy syndrome in cyclophosphamide-treated lupus patients.
    Rheumatol Int 2017 Dec 17;37(12):2105-2114. Epub 2017 Oct 17.
    Department of Rheumatology and Clinical Immunology, Clinical Hospital Centre Rijeka, Krešimirova 42, 51000, Rijeka, Croatia.
    The cyclophosphamide as a predisposing factor for Posterior Reversible Encephalopathy Syndrome (PRES) and therapeutic option for systemic lupus erythematosus (SLE) is still confusing. The first and only case of PRES, probably induced by cyclophosphamide, in Croatia followed by the findings of 36 SLE patients diagnosed with PRES after treatment with cyclophosphamide worldwide are described. An 18-year-old Caucasian female patient with a 1-year history of SLE was admitted to the hospital due to lupus nephritis and acute arthritis. Read More

    Rheopheresis as a causal therapy option for systemic scleroderma (SSc).
    Clin Hemorheol Microcirc 2017 Oct 7. Epub 2017 Oct 7.
    Department of Dermatology, University Medicine Greifswald, Greifswald, Germany.
    A complex pathomechanism accounts systemic sclerosis as a form of collagenosis. A triad of vasculopathy, autoinflammation, and dysbalance of the fibroblast function can be seen as cause, as well as symptomatic appearance. Comparative with other collagenoses, e. Read More

    Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus.
    PLoS One 2017 16;12(10):e0186414. Epub 2017 Oct 16.
    Department of Rheumatology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
    Although quotient of alpha2 macroglobulin (Qα2MG) was previously reported to be useful for the evaluation of blood-brain barrier (BBB) function, it is not commonly used. We therefore evaluated BBB function among the various subsets of neuropsychiatric systemic lupus erythematosus (NPSLE) using quotient Q α2MG. Furthermore, we determined the correlation between Q α2MG and cerebrospinal (CSF) interleukin (IL)-6 level and quotient complement component 3 (Q C3). Read More

    Effect of long-term hydroxychloroquine on vascular events in patients with systemic lupus erythematosus: a database prospective cohort study.
    Rheumatology (Oxford) 2017 Sep 27. Epub 2017 Sep 27.
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Keelung, Taiwan.
    Objectives: The incidence of thromboembolism in patients with SLE is higher than that in the general population. HCQ, widely used to treat lupus, may have vascular protective effects. The aim of this study was to determine whether long-term HCQ exposure is associated with decreased thromboembolism risk in SLE. Read More

    Missing in action-The meaning of cell death in tissue damage and inflammation.
    Immunol Rev 2017 Nov;280(1):26-40
    Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany.
    Billions of cells die every day in higher organisms as part of the normal process of tissue homeostasis. During special conditions like in development, acute infections, mechanical injuries, and immunity, cell death is a common denominator and it exerts profound effects in the outcome of these scenarios. To prevent the accumulation of aged, superfluous, infected, damaged and dead cells, professional phagocytes act in a rapid and efficient manner to clear the battle field and avoid spread of the destruction. Read More

    Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes.
    Endocrinol Diabetes Metab Case Rep 2017 6;2017. Epub 2017 Oct 6.
    Department of Diabetes and Endocrinology, Newham University Hospital, Barts Health NHS Trust, London, UK.
    We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). Read More

    Continous Rituximab treatment for recurrent diffuse alveolar hemorrhage in a patient with systemic lupus erythematosus and antiphosholipid syndrome.
    Respir Med Case Rep 2017 30;22:263-265. Epub 2017 Sep 30.
    Department of Pathology, Aarhus University Hospital, Denmark.
    Diffuse alveolar hemorrhage (DAH) is a rare but potentially fatal complication in systemic lupus erythematosus (SLE). DAH is typically characterized by hemoptysis, dyspnea, new infiltrates on chest x-rays or CT-scans and a drop in hemoglobin. DAH is seen in less than 2% of patients with SLE and carries a high acute mortality risk of up to 70-90%. Read More

    Recent topics in IMiDs and cereblon.
    Rinsho Ketsueki 2017 ;58(10):2067-2073
    Department of Nanoparticle Translational Research, Tokyo Medical University.
    Immunomodulatory drugs (IMiDs) are a new class of anticancer compounds that are derived from thalidomide. Lenalidomide and pomalidomide are well-known IMiDs, and they have already been approved by FDA for the treatment of several diseases, including multiple myeloma. Cereblon (CRBN) is a common primary target for IMiDs. Read More

    The Role of Brain-Reactive Autoantibodies in Brain Pathology and Cognitive Impairment.
    Front Immunol 2017 11;8:1101. Epub 2017 Sep 11.
    The Feinstein Institute for Medical Research, The Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, Northwell Health System, Manhasset, NY, United States.
    Antibodies to different brain proteins have been recently found to be associated with an increasing number of different autoimmune diseases. They need to penetrate the blood-brain barrier (BBB) in order to bind antigens within the central nervous system (CNS). They can target either neuronal or non-neuronal antigen and result in damage either by themselves or in synergy with other inflammatory mediators. Read More

    Borrelia Lymphocytoma Mimicking Butterfly Rash in a Pediatric Patient.
    Am J Dermatopathol 2017 Sep 20. Epub 2017 Sep 20.
    *Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain; and †Friedrichshafen Dermatopathologie, Friedrichshafen, Germany.
    A 5-year-old girl presented with a facial butterfly rash that persisted for 5 months without arthralgia, fever, malaise, photosensitivity, or other symptoms. Lupus erythematosus was clinically suspected. All blood tests were negative or within normal values. Read More

    Sudden Collapse in the First Trimester: Report of Hyperacute Renal Failure Secondary to Collapsing Glomerulopathy as the Initial Presentation of Lupus.
    Cureus 2017 Jul 24;9(7):e1509. Epub 2017 Jul 24.
    Internal Medicine, Quillen College of Medicine, East Tennessee State University.
    Hyperacute renal failure is rarely the initial presentation of systemic lupus erythematosus (SLE). Pregnancy can predispose untreated lupus nephritis to acute renal failure. Collapsing glomerulopathy (CG) type of renal failure is not a new clinicopathological entity. Read More

    A large retrospective review of persistent proteinuria in children.
    J Formos Med Assoc 2017 Sep 21. Epub 2017 Sep 21.
    Department of Pediatrics, National Taiwan University Children's Hospital, College of Medicine, National Taiwan University, No. 8 Chung-Shan South Rd., Taipei, 10061, Taiwan. Electronic address:
    Background: Proteinuria is a common finding in children. It may be due to a benign cause, but it can also represent early renal injury. Of children with persistent proteinuria noted in mass urine screening programs, 35% have a urine protein level greater than 100 mg/dl and many of them are associated with many underlying renal diseases. Read More

    Cutaneous Lupus: A Brief Review of Old and New Medical Therapeutic Options.
    J Investig Dermatol Symp Proc 2017 Oct;18(2):S64-S68
    Department of Dermatology, Virginia Commonwealth University, Richmond, Virginia, USA.
    Systemic lupus erythematosus is a chronic inflammatory condition which affects predominantly women in their 30s. It has several clinical manifestations, including skin lesions that can be classified as acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous lupus erythematosus. A multifaceted approach to treating cutaneous lupus is advocated. Read More

    [Angina Pectoris in a Young Woman with Lupus Erythematosus].
    Dtsch Med Wochenschr 2017 Sep 22;142(19):1449-1452. Epub 2017 Sep 22.
    Klinik III für Innere Medizin, Herzzentrum, Universität zu Köln, Köln.
    History and clinical findings We present a 31-year old woman with a 6-year history of cutaneous lupus erythematosus (CLE) who presented to the emergency room with typical chest pain. ECG and transthoracic echocardiography were normal. Her working diagnosis of pericarditis was made due to systemic progression of her lupus erythematosus (LE). Read More

    Diagnosis of systemic inflammatory diseases among patients admitted for acute pericarditis with pericardial effusion.
    J Cardiovasc Med (Hagerstown) 2017 Nov;18(11):875-880
    aDépartement de Médecine Interne bDépartement d'Epidémiologie et Recherche Clinique cDépartement d'Information Médicale dDépartement de Cardiologie, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris eINSERM U1149 fDépartement Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases), Paris, France.
    Aims: Acute pericarditis may be the heralding manifestation of various systemic inflammatory diseases (SIDs). The aim of this study was to identify clinical indicators for SIDs in patients admitted for acute pericarditis with pericardial effusion.

    Methods: All consecutive adult patients hospitalized in a Department of Internal Medicine over a 10-year period for acute pericarditis with pericardial effusion were retrospectively reviewed. Read More

    Cardiovascular magnetic resonance detects silent heart disease missed by echocardiography in systemic lupus erythematosus.
    Lupus 2017 Jan 1:961203317731533. Epub 2017 Jan 1.
    1 Onassis Cardiac Surgery Center, Athens, Greece.
    Background Accurate diagnosis of cardiovascular involvement in systemic lupus erythematosus (SLE) remains challenging, due to limitations of echocardiography. We hypothesized that cardiovascular magnetic resonance can detect cardiac lesions missed by echocardiography in SLE patients with atypical symptoms. Aim To use cardiovascular magnetic resonance in SLE patients with atypical symptoms and investigate the possibility of silent heart disease, missed by echocardiography. Read More

    Use of eculizumab in a systemic lupus erythemathosus patient presenting thrombotic microangiopathy and heterozygous deletion in CFHR1-CFHR3. A case report and systematic review.
    Clin Rheumatol 2017 Dec 13;36(12):2859-2867. Epub 2017 Sep 13.
    Department of Pediatric Nephrology, Unicamp, State University of Campinas, Campinas, Brazil.
    The association of thrombotic microangiopathy (TMA) with systemic lupus erythematosus (SLE) has been described in 0.5 to 10% of cases, and patients present worse outcome. TMA is described as the association of microangiopathic hemolytic anemia, thrombocytopenia, and an organ injury, frequently the kidney. Read More

    Evaluation of Anti-Cyclic Citrullinated Peptide Autoantibodies and C-Reactive Protein in Common Autoimmune Skin Diseases with and without Arthritis.
    J Clin Diagn Res 2017 Jul 1;11(7):BC06-BC08. Epub 2017 Jul 1.
    Professor and Hod, Department of Skin and VD, Patna Medical College and Hospital, Patna, Bihar, India.
    Introduction: Anti-Cyclic Citrullinated Peptides (CCPs) are a well known diagnostic and prognostic noble marker for rheumatoid arthritis. C-Reactive Protein (CRP) is an acute phase protein whose level rises in response to inflammation.

    Aim: This study was undertaken to show the role of the two markers (anti-CCPs and CRP) in autoimmune skin disorder and their association with associated arthritis in these disorder. Read More

    Effects of sustained i.c.v. infusion of lupus CSF and autoantibodies on behavioral phenotype and neuronal calcium signaling.
    Acta Neuropathol Commun 2017 Sep 7;5(1):70. Epub 2017 Sep 7.
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Psychology Building Rm. 303, 1280 Main St., West Hamilton, ON, L8S 4K1, Canada.
    Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease that is often accompanied by brain atrophy and diverse neuropsychiatric manifestations of unknown origin. More recently, it was observed that cerebrospinal fluid (CSF) from patients and lupus-prone mice can be neurotoxic and that acute administration of specific brain-reactive autoantibodies (BRAs) can induce deficits in isolated behavioral tasks. Given the chronic and complex nature of CNS SLE, the current study examines broad behavioral performance and neuronal Ca(2+) signaling in mice receiving a sustained infusion of cerebrospinal fluid (CSF) from CNS SLE patients and putative BRAs (anti-NR2A, anti-ribosomal P, and anti-α-tubulin). Read More

    Prognostic factors of mortality in Iranian patients with systemic lupus erythematosus admitted to intensive care unit.
    Clin Rheumatol 2017 Nov 6;36(11):2471-2477. Epub 2017 Sep 6.
    Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA.
    The aim was to determine the course, outcome, and determinants of mortality in patients with systemic lupus erythematosus (SLE) in intensive care unit (ICU). SLE patients admitted to ICU from 2004 to 2015 were recruited retrospectively. Demographic data, disease characteristics, causes of admission, baseline SLE disease activity index-2K (SLEDAI-2K) and Acute Physiologic and Chronic Health Evaluation II (APACHE) score, the outcome, and the causes of death were recorded. Read More

    [Manifestations of the connective tissue associated interstitial lung disease under high resolution computed tomography].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Aug;42(8):934-939
    Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To analyze the features of the connective tissue associated interstitial lung disease (CTD-ILD) by high resolution computed tomography (HRCT).
 Methods: A total of 127 patients with CTD-ILD, who were diagnosed by clinic laboratory examination and pathology in Xiangya Hospital of Central South University form September 2013 to September 2015, were enrolled for this study. Their lung features of HRCT imaging were retrospectively analyzed. Read More

    Tubuloreticular Inclusions in the Absence of Systemic Lupus Erythematosus and HIV Infection: A Report of Three Pediatric Cases.
    Case Rep Nephrol Dial 2017 May-Aug;7(2):91-101. Epub 2017 Jun 23.
    Children's Medical Center, Dallas, Texas, USA.
    Tubuloreticular inclusions (TRIs) are subcellular structures located within the cisternae of endoplasmic reticulum. Formation of TRIs has been linked to the exposure of excess interferon (IFN), either from endogenous or exogenous sources. In renal disease, TRIs have been most commonly associated with systemic lupus erythematosus (SLE), and human immunodeficiency virus-associated nephropathy (HIVAN). Read More

    Acute vision loss in systemic lupus erythematosus: bilateral combined retinal artery and vein occlusion as a catastrophic form of clinical flare.
    Lupus 2017 Jan 1:961203317727602. Epub 2017 Jan 1.
    1 Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
    Presentation of a combination of branch retinal artery occlusion (BRAO)/central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO) in systemic lupus erythematosus (SLE) is extremely rare. Herein, we have presented the case of a 29-year-old female with SLE, who simultaneously developed bilateral CRVO and BRAO/CRAO in the absence of antiphospholipid syndrome (APS) as a catastrophic form of clinical flare. A combinatorial diagnosis of CRVO and BRAO/CRAO should be considered during clinical flare-up in a patient with SLE who presents with rapidly progressive visual loss. Read More

    Bullous systemic lupus erythematosus in a 6-year-old boy.
    Pediatr Dermatol 2017 Nov 29;34(6):e313-e316. Epub 2017 Aug 29.
    Department of Dermatology, School of Medicine, Yale University, New Haven, CT, USA.
    Bullous systemic lupus erythematosus (BSLE) is a rare subepidermal blistering disorder characterized by an acute vesiculobullous eruption in a subset of individuals with systemic lupus erythematosus. BSLE most commonly affects young women and only rarely affects children. Herein we report a rare case of BSLE in a 6-year-old boy. Read More

    Sex Differences in Pediatric Rheumatology.
    Clin Rev Allergy Immunol 2017 Aug 28. Epub 2017 Aug 28.
    Anna Meyer Children's Hospital and University of Florence, Viale Pieraccini 24, 50139, Florence, Italy.
    Autoimmune diseases affect up to 10% of the world's population and, as a whole, they are far more common in females, although differences exist according to the single disease and also in different age groups. In childhood-onset autoimmune diseases, the sex bias is generally less evident than in adults, probably for the different hormonal milieau, being estrogens strongly implicated in the development of autoimmunity. Still, some rheumatic conditions, such as juvenile idiopathic arthritis (JIA), show a strong predilection for girls (F:M = 3-6. Read More

    Hypokalemic Paralysis: A Hidden Card of Several Autoimmune Diseases.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 3;10:1179544117722763. Epub 2017 Aug 3.
    Rheumatology Department, Hospital Guillermo Almenara Irigoyen, La Victoria, Peru.
    Acute hypokalemic paralysis is a rare and potentially fatal condition, with few related causes, one of which highlights distal renal tubular acidosis (dRTA). Distal renal tubular acidosis is a rare complication of several autoimmune diseases such as systemic lupus erythematosus, Sjögren's syndrome, and Hashimoto thyroiditis. We report a case of a lupic patient who presented rapidly progressive quadriparesis in the context of active renal disease. Read More

    Update upon efficacy and safety of etanercept for the treatment of spondyloarthritis and juvenile idiopathic arthritis.
    Mod Rheumatol 2017 Aug 24:1-15. Epub 2017 Aug 24.
    a Department of Internal Medicine, Scleroderma Unit, Clinical Immunology Unit , University of Genova and IRCCS-Azienda Ospedaliera Universitaria San Martino , Genova , Italy.
    TNF-α inhibitors have demonstrated efficacy both as monotherapy and in combination with disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of chronic inflammatory immune-mediated diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis (AS), psoriasis (Ps) and/or psoriatic arthritis (PsA) and may be administered off-label to treat disseminated granuloma annulare, systemic lupus erythematosus and systemic sclerosis. There are several TNF-α inhibitors available for clinical use including infliximab, adalimumab, golimumab, certolizumab pegol and etanercept. In this article, we discuss the efficacy and safety of etanercept in the treatment of spondyloarthritis and juvenile idiopathic arthritis (JIA). Read More

    Renal transplantation in systemic lupus erythematosus: Comparison of graft survival with other causes of end-stage renal disease.
    Reumatol Clin 2017 Aug 14. Epub 2017 Aug 14.
    Servicio de Reumatología, UMAE, Hospital de Especialidades «Dr. Bernardo Sepúlveda Gutiérrez», Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.
    Introduction: End-stage renal disease (ESRD) due to lupus nephritis (LN) occurs in 10%-30% of patients. Initially systemic lupus erythematosus (SLE) was a contraindication for kidney transplantation (KT). Today, long-term graft survival remains controversial. Read More

    Urticaria vasculitis in a child: a case report and literature review.
    Clin Case Rep 2017 Aug 21;5(8):1255-1257. Epub 2017 Jun 21.
    Department of DermatologyHospital Universitario Severo OchoaAvenida de Orellana28911LeganésMadridSpain.
    Annular urticarial lesions in a child must establish a main differential diagnosis with urticaria multiforme, common urticaria, acute hemorrhagic edema of infancy, erythema marginatum, erythema annulare centrifugum, annular erythema in childhood, erythema multiforme, Sweet's syndrome, Schönlein-Henoch purpura, erythematosus lupus, several systemic vasculitis, and serum sickness. Read More

    Cerebral tuberculosis in a patient with systemic lupus erythematosus following cyclophosphamide treatment: a case report.
    Lupus 2017 Jan 1:961203317722849. Epub 2017 Jan 1.
    1 Louise Coote Lupus Unit, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.
    Central nervous system (CNS) tuberculosis (TB) is a rare but catastrophic event in patients with systemic lupus erythematosus (SLE). Here we report a case of cerebral TB in a patient with lupus myocarditis and nephritis, following cyclophosphamide immunosuppression. To our knowledge this is the first reported case of cerebral TB in SLE in a non-endemic country. Read More

    Acute Myocardial Infarction in Young Systemic Lupus Erythematosus Patient with Normal Coronary Arteries.
    Cureus 2017 Jun 19;9(6):e1370. Epub 2017 Jun 19.
    Cardiology, West Virginia University - Charleston Division.
    A 34-year-old female with a past medical history of systemic lupus erythematosus (SLE) and a deep venous thrombosis experienced substernal chest pain for 24 hours. Her physical exam was remarkable for brown macular rash over the face. Her initial electrocardiogram showed ST depression in lead V3-V6 along with an elevated troponin I level of 1. Read More

    Off-label use of rituximab in autoimmune disease in the Top End of the Northern Territory, 2008-2016.
    Intern Med J 2017 Jul 25. Epub 2017 Jul 25.
    clinical immunologist and allergist, Cairns Hospital, QLD.
    Background: Rituximab, an anti-CD20 B cell depleting monoclonal antibody, is increasingly prescribed off-label for a range of autoimmune diseases. There has not previously been an audit of off-label rituximab use in the Northern Territory, where the majority of patients are Aboriginal.

    Aims: To retrospectively evaluate off-label rituximab use in autoimmune diseases in the Top End of the Northern Territory. Read More

    Serum ferritin as an activity marker for granulamotosis with polyangiitis.
    Ren Fail 2017 Nov;39(1):566-569
    a Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine , Gazi University , Ankara , Turkey.
    Background: Serum ferritin correlates well with the activities of systemic lupus erythematosus (SLE) and dermatomyositis, but it has not been previously studied in patients with vasculitis.

    Methods: Medical records of granulomatosis with polyangiitis (GPA, Wegener's granulomatosis) patients with at least six months of regular follow-up were evaluated. The activity of GPA was assessed with Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG). Read More

    Myelitis in systemic lupus erythematosus.
    J Clin Neurosci 2017 Oct 8;44:18-22. Epub 2017 Jul 8.
    Department of Nephrology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China; Department of Medicine, The University of Hong Kong - Queen Mary Hospital, Pokfulam Road, Hong Kong, China. Electronic address:
    SLE-associated acute transverse myelitis (ATM) is a rare, but potentially severe complication of Systemic lupus erythematosus (SLE), and may lead to significant motor, sensory and autonomic dysfunctions in the central nervous system resulting in marked neurological deficits. It is important to recognize its clinical feature to allow timely diagnosis and management of this condition. In this review, we aimed to provide the reader with the understanding of its clinical presentation and classification, the underlying pathological, MRI (magnetic resonance imaging) appearance, and current status of management, with an emphasis on recent discoveries and advancements. Read More

    Systemic lupus erythematosus, following prodromal idiopathic thrombocytopenic purpura, presenting with skin lesions resembling malignant atrophic papulosis.
    Clin Exp Dermatol 2017 Oct 10;42(7):774-776. Epub 2017 Jul 10.
    Department of Dermatology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.
    Systemic lupus erythematosus (SLE) is an autoimmune disease. Its incidence in the UK is approximately 1 per 10 000. Cutaneous involvement, encompassing acute, subacute and chronic disease, occurs in over two-thirds of cases, and can often be the first clue to diagnosis. Read More

    Unusual acute lupus hemophagocytic syndrome - a test of diagnostic criteria: a case report.
    J Med Case Rep 2017 Jul 7;11(1):185. Epub 2017 Jul 7.
    Postgraduate Institute of Medicine, University of Colombo, Colombo, Sri Lanka.
    Background: Hemophagocytic lymphohistiocytosis is an aggressive life-threatening syndrome of excessive immune activation. Hemophagocytic lymphohistiocytosis due to systemic lupus erythematosus is described as acute lupus hemophagocytic syndrome. Acute lupus hemophagocytic syndrome presenting with negative antinuclear antibody is uncommon. Read More

    Successful treatment using corticosteroid combined antibiotic for acute acalculous cholecystitis patients with systemic lupus erythematosus.
    Medicine (Baltimore) 2017 Jul;96(27):e7478
    Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, P.R. China.
    There is no consensus of treatments for acute acalculous cholecystitis with systemic lupus erythematosus (SLE). The study was aimed to investigate the effect of the corticosteroid for these patients.A series of patients who were diagnosed as acute acalculous cholecystitis with SLE in the period from January 2012 to December 2016 at our hospital were included. Read More

    Cardiovascular and Pulmonary Manifestations of Systemic Lupus Erythematosus.
    Curr Rheumatol Rev 2017 Jul 4. Epub 2017 Jul 4.
    University Health Network, Toronto, Ontario. Canada.
    Background: Systemic lupus erythematosus (SLE) is characterized by various clinical manifestations and immunologic abnormalities. Among clinical manifestations, cardiovascular and respiratory system involvement is increasingly recognized as critical for patients' prognosis.

    Objective: Heart involvement, most commonly presents with pericarditis. Read More

    A Retrospective Study of Acute Renal Failure in Children: Its Incidence, Etiology, Complications and Prognosis.
    Cureus 2017 May 25;9(5):e1274. Epub 2017 May 25.
    Department of Paediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, P.R.China.
    Background: Acute renal failure (ARF) developed due to various causes and may lead to significant morbidity and mortality among pediatric patients.

    Objectives: The study was conducted to determine the incidence, etiology, outcome of treatment and clinical presentation of ARF in pediatric patients in Somalia.

    Methods: Comprehensive case history of 39 pediatric patients below 12 years of age, admitted with renal diseases in four tertiary care hospitals in Hargeisa and Borama cities in Somalia during December 2015 to November 2016. Read More

    Acute tubulointerstitial nephritis in an HLA-B27-positive patient with axial spondyloarthritis being treated with adalimumab.
    Reumatol Clin 2017 Jun 14. Epub 2017 Jun 14.
    Servicio de Anatomía Patológica, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
    Antagonists of tumor necrosis factor-alpha (ATNF) are used for the treatment of multiple diseases such as psoriatic arthritis, Crohn's disease, ankylosing spondylitis and juvenile idiopathic arthritis, usually, when they are refractory to first-line treatment(1). The use of ATNF has been associated with the induction of autoimmune diseases such as systemic lupus erythematosus-like disease, vasculitis, sarcoidosis-like diseases and, recently, acute granulomatous tubulointerstitial nephritis. We report a case of acute nongranulomatous tubulointerstitial nephritis in an HLA-B27-positive patient with axial spondyloarthritis and Crohn's disease being treated with adalimumab. Read More

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