4,336 results match your criteria Lupus Erythematosus Acute


Analysis of interleukin-17 and interleukin-23 for estimating disease activity and predicting the response to treatment in active lupus nephritis patients.

Immunol Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Infectious Diseases, the 900(th) Hospital of the PLA of China, No.156 North Road West 2nd Ring Road Fuzhou, 350013, China; Clinical educational Institute of the 900(th) Hospital of the PLA affiliated Fujian Medical University, Fuzhou, China. Electronic address:

Renal biopsy is a "gold standard" for establishing the diagnosis and assessing prognosis and monitoring therapy in lupus nephritis (LN) patients, but it is an invasive and inconvenient procedure. Evidences showed that interleukin-17(IL-17) and interleukin-23(IL-23) may be as alternative biomarkers for diagnosing LN, monitoring LN activity and predicting the response to treatment of LN. To analyze the roles of IL-17 and IL-23 in evaluation activity of LN and predicting active LN response to immunosuppressive treatment, by comparison between IL-17, IL-23 and clinical data of LN. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478183043
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http://dx.doi.org/10.1016/j.imlet.2019.04.002DOI Listing
April 2019
1 Read

Etiology and outcome of pulmonary renal syndrome: Retrospective study from a tertiary care hospitaln.

J Pak Med Assoc 2019 Apr;69(4):588-591

Aga Khan University, KARACHI, PAKISTAN.

To determine the aetiology, clinical characteristics and outcome of patients admitted with pulmonary renal syndrome (PRS). This retrospective analysis was conducted at Aga Khan University Hospital from 2011 to 2015. A total of 17 adult patients admitted with PRS were included and followed up for a period of one year for the outcome of PRS as recovery, dialysis dependency or death. Read More

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April 2019
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[Systemic Lupus Erythematosus].

Authors:
Tetsuya Tsuchida

Brain Nerve 2019 Apr;71(4):317-321

Department of Dermatology, Saitama Medical University.

The cutaneous manifestations of lupus erythematosus (LE) include LE-specific and LE-nonspecific skin lesions. LE-specific skin lesions are divided into chronic, subacute, and acute types. The representatives of the chronic and acute types are discoid lupus erythematosus (DLE) and butterfly rash, respectively. Read More

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http://dx.doi.org/10.11477/mf.1416201268DOI Listing
April 2019
1 Read

[Coronary involvement and nephrotic syndrome in systemic lupus: A case report].

Rev Med Interne 2019 Apr 10. Epub 2019 Apr 10.

Service de médecine interne 2, Centre national de référence maladies systémiques rares, lupus et syndrome des anticorps antiphospholipides, hôpital de la Pitié-Salpêtrière, Sorbonne université, Assistance publique-Hôpitaux de Paris, 47-83, boulevard de l'Hôpital, 75013 Paris, France. Electronic address:

Introduction: Heart failure during systemic lupus erythematosus has various causes.

Case Report: A 29-year-old female presented with a systemic lupus flare and a nephrotic syndrome, followed by cardiogenic shock requiring extra-corporeal membranous oxygenation. Ventricular dysfunction was related to massive myocardial infarction due to an anterior interventricular artery thrombosis and an underlying atheroma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02488663193009
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http://dx.doi.org/10.1016/j.revmed.2019.03.001DOI Listing
April 2019
3 Reads

Overlap myositis, a distinct entity beyond primary inflammatory myositis: A retrospective analysis of a large cohort from the REMICAM registry.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Inflammatory idiopathic myositis (IIM) comprises a heterogeneous group of systemic muscular diseases that can occur together with other connective tissue diseases (CTD), named overlap myositis (OM). The question of whether OM is a distinct entity still remains controversial.

Aim: The present study was conducted to assess the clinical and prognostic differences between patients diagnosed with OM, primary polymyositis (PM) and primary dermatomyositis (DM). Read More

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http://dx.doi.org/10.1111/1756-185X.13559DOI Listing
April 2019
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Challenging Diagnostics of Biofilm Associated Periprosthetic Infection in Immunocompromised Patient: A Clinical Case.

Open Access Maced J Med Sci 2019 Mar 13;7(5):786-790. Epub 2019 Mar 13.

Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Kurgan, Kurgan Oblast, Russia.

Background: Periprosthetic joint infection (PJI) is a devastating complication of joint arthroplasty. The identification of microorganisms in biofilm-related PJI is challenging yet significant stage of the treatment process. Medical microbiology methods, such as pure culture isolation, remain the gold standard. Read More

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https://www.id-press.eu/mjms/article/view/oamjms.2019.180
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http://dx.doi.org/10.3889/oamjms.2019.180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447350PMC
March 2019
2 Reads

Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus.

Case Rep Nephrol 2019 5;2019:8354823. Epub 2019 Mar 5.

Department of Internal Medicine, Division of Nephrology, Houston, TX, USA.

Lupus nephritis is a common manifestation of systemic lupus erythematosus (SLE). IgA nephropathy is a common type of primary glomerulonephritis. Renal manifestations in SLE patients are often due to lupus nephritis; however, renal diseases unrelated to lupus nephritis are rarely reported. Read More

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https://www.hindawi.com/journals/crin/2019/8354823/
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http://dx.doi.org/10.1155/2019/8354823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425374PMC
March 2019
4 Reads

Acute myocardial infarction and renal dysfunction due to chronic extreme anemia (hemoglobin 2.5 g/dL) in immune thrombocytopenia.

Proc (Bayl Univ Med Cent) 2018 Oct 23;31(4):508-510. Epub 2018 Oct 23.

Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at HoustonHoustonTexas.

Immune thrombocytopenic purpura (ITP) is an acquired thrombocytopenia where autoantibodies are generated against platelet antigens. Primary ITP is often idiopathic, whereas secondary ITP has many potential causes, including drug induced, infection related (human immunodeficiency virus, hepatitis C), leukemias, or autoimmune such as systemic lupus erythematosus. ITP is a common cause of thrombocytopenia in asymptomatic individuals, where evidence of bleeding may be minor or absent. Read More

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http://dx.doi.org/10.1080/08998280.2018.1499317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413974PMC
October 2018
2 Reads

Odd cause for acute anicteric hepatitis in a woman with systemic lupus erythematosus.

BMJ Case Rep 2019 Apr 4;12(4). Epub 2019 Apr 4.

Rheumatology, Center for Arthritis and Rheumatism, Kochi, Kerala, India.

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http://dx.doi.org/10.1136/bcr-2019-229230DOI Listing
April 2019
5 Reads

Ruptured Multifocal Hepatic Aneurysms in a Woman with Systemic Lupus Erythematosus Successfully Treated with Transcatheter Arterial Embolization: A Case Report and Literature Review.

Case Reports Hepatol 2019 26;2019:6272419. Epub 2019 Feb 26.

Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

To present a first reported case of ruptured multifocal hepatic aneurysms in a woman with systemic lupus erythematosus (SLE) who was treated successfully with transcatheter arterial embolization (TAE) in literature, similar cases in the previous English literature were also reviewed and analyzed to summarize the clinical manifestations, management, and outcome in these patients. The data were gathered from the medical record and literature reviews were searched from PudMed. In our review, patients with SLE-related hepatic aneurysms were often middle-aged females. Read More

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http://dx.doi.org/10.1155/2019/6272419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413403PMC
February 2019
3 Reads

Neutrophil extracellular traps are associated with the pathogenesis of diffuse alveolar hemorrhage in murine lupus.

J Autoimmun 2019 Mar 28. Epub 2019 Mar 28.

Aix-Marseille Univ, INSERM, INRA, C2VN, Marseille, France; Department of Internal Medicine and Clinical Immunology CHU Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France.

Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of systemic lupus erythematosus (SLE) and systemic vasculitis. Although initially described to have antibacterial properties, increasing evidence suggests that neutrophil extracellular traps (NETs) have a detrimental role in both autoimmune diseases and acute lung injury. We investigated whether NETs could be detected in a murine model of pristane-induced lupus DAH and contribute to lung injury. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.03.009DOI Listing
March 2019
2 Reads

Myeloid disorders after autoimmune disease.

Best Pract Res Clin Haematol 2019 03 7;32(1):74-88. Epub 2019 Feb 7.

Yale University School of Medicine, Department of Medicine, Section of Hematology, New Haven, CT, USA. Electronic address:

Autoimmune diseases (ADs) are associated with an increased risk not only of lymphoproliferative disorders but also of myeloid malignancies. The excess risk of myelodysplastic syndromes and/or acute myeloid leukemia is observed across several AD types, including systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disorders, multiple sclerosis, among others. The risk of developing myeloid neoplasms (MNs) is dependent on several variables, including the specific AD type, chronicity and severity of the AD, type and duration of exposure of disease modifying anti-rheumatic drugs or cytotoxics/immunosuppressives, and genetic predisposition risk. Read More

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http://dx.doi.org/10.1016/j.beha.2019.02.002DOI Listing
March 2019
2 Reads

Treatment of neuromyelitis optica spectrum disorders.

Curr Opin Rheumatol 2019 May;31(3):250-255

Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.

Purpose Of Review: This review discusses concepts for diagnosing neuromyelitis optica spectrum disorders (NMOSD), distinguishing NMOSD from other inflammatory diseases of the central nervous system, and highlights recent and forthcoming data on acute and maintenance therapy of NMOSD.

Recent Findings: The neurologic manifestations of NMOSD are heterogenous, extending beyond classic presentations of optic neuritis and longitudinally extensive transverse myelitis. NMOSD may be comorbid with rheumatologic diseases, such as systemic lupus erythematosus, but is recognized as a distinct entity. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000603DOI Listing
May 2019
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Left ventricular pseudoaneurysm associated with systemic lupus erythematosus.

Lupus 2019 Mar 24:961203319837359. Epub 2019 Mar 24.

1 Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Systemic lupus erythematosus (SLE) is associated with several cardiac manifestations but, to our knowledge, there have been no previously published reports on left ventricular (LV) pseudoaneurysm in this disease. We describe a case of a 30-year-old woman with SLE who presented with a disease flare (acute and subacute cutaneous lupus, pericarditis, fever, leukopenia) associated with heart failure syndrome. The patient was diagnosed with a large LV pseudoaneurysm and a bovine pericardium patch closure was performed. Read More

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http://dx.doi.org/10.1177/0961203319837359DOI Listing
March 2019
2 Reads

Glycated albumin level is significantly decreased in patients suffering nephrotic syndrome.

Prog Mol Biol Transl Sci 2019 6;162:307-319. Epub 2019 Mar 6.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Serum glycated albumin (GA) level is used along with that of glucose and glycated hemoglobin (HbA1c) as indicators of glycemic control for diabetic patients. Although serum GA levels are affected by blood glucose level, they are also influenced by serum albumin metabolism and other pathological conditions. However, a systematic comparison of the serum GA levels in different types of human diseases has not been reported. Read More

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http://dx.doi.org/10.1016/bs.pmbts.2019.01.006DOI Listing
March 2019
1 Read

Chronic Cutaneous Lupus Erythematosus: Depression Burden and Associated Factors.

Am J Clin Dermatol 2019 Mar 15. Epub 2019 Mar 15.

Department of Medicine, Division of Rheumatology, Emory University, Atlanta, GA, USA.

Objectives: Depression may occur in up to 30% of individuals with cutaneous lupus erythematosus (CLE), many of whom may also have systemic manifestations. Chronic cutaneous lupus erythematosus (CCLE) conditions are less likely to present systemic involvement than acute and subacute conditions but more often cause permanent scarring and dyspigmentation. However, little is known about depression in those who have CCLE confined to the skin (primary CCLE). Read More

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http://dx.doi.org/10.1007/s40257-019-00429-7DOI Listing
March 2019
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Application of Plasma Exchange in Steroid-Responsive Encephalopathy.

Front Immunol 2019 27;10:324. Epub 2019 Feb 27.

Chongqing Key Laboratory of Neurology, Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Plasma exchange has been widely used in autoimmune neurological diseases and is the standard treatment for myasthenia gravis crisis and Guillain-Barre syndrome. A growing body of research suggests that, in the clinical application of steroid-responsive encephalopathy, such as for Hashimoto's encephalopathy, limbic encephalitis, systemic lupus erythematosus encephalopathy, ANCA-associated vasculitis encephalopathy, and acute disseminated encephalomyelitis, plasma exchange is a safe, and effective option when steroids or other immunosuppressive therapies are ineffective in the short term or when contraindications are present. Additionally, plasma exchange can also be used alone or in combination with steroids, immunoglobulins, or other immunosuppressive agents to treat steroid-responsive encephalopathy. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400967PMC
February 2019
1 Read

Analysis of the Association of Administration of various glucocorticoids with development of acute pancreatitis using US Food and Drug Administration adverse event reporting system (FAERS).

J Pharm Health Care Sci 2019 28;5. Epub 2019 Feb 28.

3Department of Pharmacotherapy, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588 Japan.

Background: There have been debates about the association between the administration of glucocorticoids and the development of acute pancreatitis, since many anecdotal cases of this adverse event were affected either by concomitant diseases (such as systemic lupus erythematosus, SLE) that may develop acute pancreatitis without glucocorticoid treatment or by co-administered drugs with high risk for the event. The aim of the present study was to explore whether disproportionally elevated signals of developing acute pancreatitis may be detected in patients receiving glucocorticoids as compared those receiving other drugs.

Methods: We retrieved spontaneously reported cases of acute pancreatitis and clinically related adverse events (target events) from the US Food and Drug Administration Adverse Event Reporting System (FAERS) using 18 preferred terms (PTs). Read More

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http://dx.doi.org/10.1186/s40780-019-0134-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394067PMC
February 2019
1 Read

MicroRNA expression, targeting, release dynamics and early-warning biomarkers in acute cardiotoxicity induced by triptolide in rats.

Biomed Pharmacother 2019 Mar 31;111:1467-1477. Epub 2019 Jan 31.

Epigenetics Laboratory, Institute of Interdisciplinary Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Tripterygium wilfordii Hook. F. is a plant used in traditional Chinese medicine to treat rheumatoid arthritis, lupus erythematosus, and psoriasis in China. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.12.109DOI Listing
March 2019
5 Reads

Prevalence, outcome and prognostic factors of neuropsychiatric systemic lupus erythematosus: A real world single center study.

Mod Rheumatol 2019 Mar 5:1-6. Epub 2019 Mar 5.

a Department of Rheumatology and Immunology, Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) , Peking University People's Hospital , Beijing , P. R. China.

Objectives: To investigate the prevalence, outcome and prognostic factors of neuropsychiatric systemic lupus erythematosus (NPSLE).

Methods: SLE inpatients from 2005 to 2016 were included. Information on survival duration and causes of death was collected. Read More

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http://dx.doi.org/10.1080/14397595.2019.1589912DOI Listing
March 2019
5 Reads

Catastrophic Antiphospholipid Syndrome Presenting as Congestive Heart Failure in a Patient with Thrombotic Microangiopathy.

Tex Heart Inst J 2019 02 1;46(1):48-52. Epub 2019 Feb 1.

Thrombotic microangiopathic syndromes are characterized by thrombus formation leading to microangiopathic hemolytic anemia, thrombocytopenia, and end-organ injury that most often affects the kidney and brain. Patients with thrombotic microangiopathy can also present with cardiac involvement, which has been shown to worsen their prognosis. We describe the case of a 46-year-old woman who presented with acute congestive heart failure as a manifestation of catastrophic antiphospholipid syndrome, which is characterized by rapidly progressing multiorgan involvement. Read More

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http://dx.doi.org/10.14503/THIJ-17-6472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379002PMC
February 2019
2 Reads

The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases.

Ann Lab Med 2019 Jul;39(4):345-357

Departments of Rheumatology and Research and Development, Dudley Group NHS Foundation Trust (Teaching Trust of the University of Birmingham, UK), Russells Hall Hospital, Dudley, West Midlands, UK.

The platelet-to-lymphocyte ratio (PLR) has emerged as an informative marker revealing shifts in platelet and lymphocyte counts due to acute inflammatory and prothrombotic states. PLR has been extensively examined in neoplastic diseases accompanied by immune suppression and thrombosis, which can be predicted by combined blood cell counts and their ratios. Several large observational studies have demonstrated the value of shifts in PLR in evaluating the severity of systemic inflammation and predicting infections and other comorbidities, in inflammatory rheumatic diseases. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3343/alm.2019.39
Publisher Site
http://dx.doi.org/10.3343/alm.2019.39.4.345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400713PMC
July 2019
5 Reads

Bisphosphonate-induced orbital inflammation in a patient on chronic immunosuppressive therapy.

BMC Ophthalmol 2019 Feb 14;19(1):51. Epub 2019 Feb 14.

Department of Ophthalmology, University of Kansas School of Medicine, 7400 State Line Rd, Prairie Village, Kansas, USA.

Background: To report a case of orbital inflammation after bisphosphonate infusion in a patient who was already receiving immunosuppressive therapy.

Case Presentation: A 56-year-old woman presented to the ophthalmology clinic with acute onset of right eye pain 24 h after receiving her first Zolendronic acid infusion. She has a past medical history of chronic inflammatory demyelinating polyneuropathy, Sjogren's syndrome, and systemic lupus erythematosus that have been controlled with immunosuppressive therapy for three years. Read More

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http://dx.doi.org/10.1186/s12886-019-1063-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374910PMC
February 2019
1 Read

Blood-brain barrier disruption and neuroinflammation as pathophysiological mechanisms of the diffuse manifestations of neuropsychiatric systemic lupus erythematosus.

Autoimmun Rev 2019 Apr 11;18(4):426-432. Epub 2019 Feb 11.

Universidad de Antioquia, Facultad de Medicina, Grupo de Inmunología Celular e Inmunogenética-GICIG, Medellín, Colombia.

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.12.004DOI Listing
April 2019
1 Read

Use of Intravenous Immunoglobulin Therapy at Unconventional Doses in Refractory Fulminant Systemic Lupus Erythematosus.

Eur J Case Rep Intern Med 2018 27;5(9):000934. Epub 2018 Sep 27.

Rare Diseases and Periodic Fevers Research Centre, Department of Internal Medicine, Agostino Gemelli University Hospital Foundation, Catholic University of the Sacred Heart, Rome, Italy.

The use of human intravenous immunoglobulins (IVIg) in systemic lupus erythematosus (SLE) currently relies on evidence from small case series and is mainly regarded as an off-label strategy in cases that are refractory to conventional therapies or poorly controlled with high doses of corticosteroids. Standard dosage regimens typically entail the administration of a total amount of 2 g/kg of IVIg divided into five consecutive days in order to minimize the risk of severe adverse events. We herein describe the case of a 28-year-old woman with a known history of antiphospholipid syndrome (APS) who was admitted to our hospital following fulminant onset of SLE in spite of ongoing immunosuppressive therapy. Read More

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http://dx.doi.org/10.12890/2018_000934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346821PMC
September 2018
2 Reads

Choroid thickness profile in patients with lupus nephritis.

Lupus 2019 Apr 12;28(4):475-482. Epub 2019 Feb 12.

1 Centro Hospitalar de Vila Nova de Gaia Espinho, Vila Nova de Gaia, Portugal.

Background: Choroidopathy is a rare manifestation of systemic lupus erythematosus (SLE). This entity is associated with active phases of severe SLE and it is frequently accompanied by acute kidney failure, central nervous system involvement and coagulopathy.

Purpose: To evaluate the choroid thickness of patients with lupus nephritis (LN) without choroidopathy, and to compare this with that of age-matched SLE patients without LN and healthy control subjects. Read More

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http://dx.doi.org/10.1177/0961203319828525DOI Listing
April 2019
1 Read

Predictors of Mortality in Pulmonary Haemorrhage during SLE: A Single Centre Study Over Eleven Years.

Open Access Maced J Med Sci 2019 Jan 14;7(1):92-96. Epub 2019 Jan 14.

Department of Nephrology, King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia.

Background: Pulmonary haemorrhage (PH) is a serious complication during Systemic Lupus Erythematosus (SLE).

Aim: The aim was to present data on 12 patients of SLE with classic symptoms and signs of PH admitted throughout eleven years.

Methods: This retrospective study was carried out at King Abdul Aziz Specialist hospital in Taif-a tertiary care hospital in the western region of Saudi Arabia. Read More

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http://dx.doi.org/10.3889/oamjms.2019.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352490PMC
January 2019
2 Reads

Cell Membrane-Derived Microvesicles in Systemic Inflammatory Response.

Folia Biol (Praha) 2018 ;64(4):113-124

Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Human body reacts to physical, chemical and biological insults with a complex inflammatory reaction. Crucial components and executors of this response are endothelial cells, platelets, white blood cells, plasmatic coagulation system, and complement. Endothelial injury and inflammation are associated with elevated blood levels of cell membrane-derived microvesicles. Read More

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January 2018
10 Reads

[Clinical value of multiplex immune assay of antinuclear antibodies in systemic lupus erythematosus.]

Klin Lab Diagn 2018;63(7):434-438

A.S. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, 111123, Moscow, Russia.

A promising trend in the diagnosis of systemic autoimmune diseases is the multiplex immune assay (MIA) of autoantibodies and other laboratory biomarkers using microchips. The aim of the work was to study the diagnostic and prognostic significance of MIA antinuclear antibody (ANA) profiles in systemic lupus erythematosus (SLE). 94 patients with SLE, 70 patients with other rheumatic diseases and 30 healthy donors were examined. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-7-434-438DOI Listing
January 2018
1 Read

Varied responses to and efficacies of hydroxychloroquine treatment according to cutaneous lupus erythematosus subtypes in Japanese patients.

J Dermatol 2019 Apr 5;46(4):285-289. Epub 2019 Feb 5.

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Hydroxychloroquine is recommended as the first-line systemic treatment for cutaneous lupus erythematosus (CLE) in Western countries, and it was approved in Japan in 2016. However, the efficacy of hydroxychloroquine in various cutaneous lupus erythematosus subtypes in Japanese patients has not been elucidated to date. Therefore, we investigated the efficacy of hydroxychloroquine for the treatment of cutaneous manifestations according to CLE subtypes in Japanese patients. Read More

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http://dx.doi.org/10.1111/1346-8138.14802DOI Listing
April 2019
2 Reads

Yield of Screening Tests for Systemic Vasculitis in Young Adults with Ischemic Stroke.

Eur Neurol 2018 4;80(5-6):245-248. Epub 2019 Feb 4.

Department of Neurology, Inha University School of Medicine, Incheon, Republic of Korea,

Systemic vasculitis, which can involve the brain, may be one of the causes of stroke in young adults; therefore, a test panel for systemic vasculitis is considered for some young stroke patients. However, little is known about this test's yield as a screening test in young adults with ischemic stroke. We evaluated the yield of a panel for systemic vasculitis as a screening test in young patients with ischemic stroke. Read More

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http://dx.doi.org/10.1159/000496373DOI Listing
February 2019
3 Reads
1.362 Impact Factor

Season Dependent Changes in the Expression of Protein Kinase C Isoenzymes in a Female Patient with Systemic Lupus Erythematosus.

Pathol Oncol Res 2019 Apr 4;25(2):801-805. Epub 2019 Feb 4.

Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zs. str. 22, Debrecen, H-4032, Hungary.

We aimed to answer the question whether the decreased expression of protein kinase C (PKC) isoenzymes in the peripheral blood mononuclear cells (PBMC) of patients with systemic lupus erythematosus (SLE) is inherited or not. For this reason we examined the expression of PKC isoenzymes in a European white girl with acute SLE and in her healthy mother and father simultaneously in summer and winter during one year using western blotting and densitometry. We found that in the father the expression of PKC isoenzymes did not differ from that of eight healthy controls included women and men. Read More

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http://dx.doi.org/10.1007/s12253-019-00591-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449297PMC
April 2019
1 Read

Tetra-arsenic tetra-sulfide ameliorates lupus syndromes by inhibiting IL-17 producing double negative T cells.

Dermatol Ther 2019 Feb 1:e12849. Epub 2019 Feb 1.

Department of Dermatology, People's Hospital of Peking University, Beijing, China.

Systemic lupus erythematosus (SLE) is an autoimmune disease of uncertain etiology that affects multiple tissues and organs. Tetra-arsenic tetra-sulfide (As S ), a traditional Chinese medicine, is effective on acute promyelocytic leukemia with mild side effects. In our previous study, BXSB lupus-prone mice treated with As S has showed improved monocytosis, decreased serum interleukin (IL)-6 and suppressed skin, liver and renal lesions with well-tolerance. Read More

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http://dx.doi.org/10.1111/dth.12849DOI Listing
February 2019
2 Reads

The Management of Heavy Menstrual Bleeding After Percutaneous Coronary Intervention in a Woman of Reproductive Age.

Front Pharmacol 2018 15;9:1573. Epub 2019 Jan 15.

Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Heavy menstrual bleeding (HMB), previously known as menorrhagia, is in place with heavy flow and longer lasting days of bleeding during menstrual period, sequentially leading to anemia. We reported a rare case of HMB in a 33-year-old patient after percutaneous coronary intervention (PCI), who presented with acute coronary syndromes (ACS), uremia and systemic lupus erythematosus before PCI. This patient received three times of hemodialysis weekly (Monday, Wednesday, and Friday). Read More

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http://dx.doi.org/10.3389/fphar.2018.01573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341068PMC
January 2019
3 Reads

Systemic Lupus Erythematosus-Related Pancreatitis in Children: Severe and Lethal Form.

Case Rep Pediatr 2018 31;2018:4612754. Epub 2018 Dec 31.

Pediatric ICU Department, Mother-Child Pole, Mohammed VI University Hospital, Marrakesh, Morocco.

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease of unknown cause, characterized by multisystemic involvement. Its occurrence in children is rare, and acute pancreatitis is exceptional in this matter. Its diagnosis is clinical, biological, and radiological. Read More

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http://dx.doi.org/10.1155/2018/4612754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332963PMC
December 2018
4 Reads

Therapeutic plasma exchange for pediatric nonrenal disease indications and outcomes: A single-center experience.

Asian J Transfus Sci 2018 Jul-Dec;12(2):127-135

Department of Paediatrics, Apollo Children's Hospitals, Chennai, Tamil Nadu, India.

Introduction: Outcome data in pediatric plasma exchange, especially in nonrenal indications are scarce. We aimed to evaluate its role and outcome in our patients.

Subjects And Methods: A retrospective study of children admitted in the year 2016 to the Pediatric Intensive Care Unit requiring plasma exchange for nonrenal indications was undertaken. Read More

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http://dx.doi.org/10.4103/ajts.AJTS_123_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327757PMC
January 2019
6 Reads

Severe Thrombocytopenia in Patient with Dermatomyositis.

Curr Health Sci J 2018 Apr-Jun;44(2):192-196. Epub 2018 Mar 27.

Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania.

Dermatomyositis (DM) is part of a heterogeneous group of systemic diseases called idiopathic inflammatory myopathies. As in other autoimmune connective tissue diseases (CTD), abnormalities of hematopoietic tissue and/or peripheral blood cells may develop and represent an important prognostic factor. Most common CTD associated with thrombocytopenia (TP) are systemic lupus erythematosus and antiphospholipid syndrome. Read More

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http://dx.doi.org/10.12865/CHSJ.44.02.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320470PMC
March 2018
1 Read

Acute Unilateral Vision Loss Due to Optic Neuropathy in a Patient with Systemic Lupus Erythematosus.

Am J Case Rep 2019 Jan 23;20:97-100. Epub 2019 Jan 23.

Department of Internal Medicine, Mayo Clinic in Florida, Jacksonville, FL, USA.

BACKGROUND Systemic lupus erythematosus (SLE) causes sight-threatening, ophthalmologic problems that are frequently challenging to manage. Optic neuropathy is a rare ophthalmological complication of SLE that can progress to total bilateral vision loss if not identified and treated rapidly. We describe a patient with SLE who presented with an acute, painless unilateral optic neuropathy who subsequently experienced partial recovery of vision when treated with high-dose intravenous corticosteroids. Read More

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http://dx.doi.org/10.12659/AJCR.912875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350674PMC
January 2019

Systemic Lupus Erythematosus is Not Necessarily a Contraindication to Adjuvant Breast Radiation Therapy.

Cureus 2018 Nov 13;10(11):e3584. Epub 2018 Nov 13.

Oncology, University of Calgary, Calgary, CAN.

A 41-year-old woman presented with pT4dN1aM0, right-sided, inflammatory breast cancer. She had a co-morbid diagnosis of systemic lupus erythematosus (SLE) at the age of 20 and was found to have significant kidney involvement (lupus-associated nephritis) at the age of 28. She went on to receive six cycles of neoadjuvant chemotherapy consisting of fluorouracil, epirubicin, cyclophosphamide, and docetaxcel (FEC-D) after which she had radiographically stable disease. Read More

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https://www.cureus.com/articles/15987-systemic-lupus-erythem
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http://dx.doi.org/10.7759/cureus.3584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334888PMC
November 2018
14 Reads

Sub-acute Cardiac Tamponade as an Early Clinical Presentation of Childhood Systemic Lupus Erythematosus: A Case Report.

Cureus 2018 Oct 22;10(10):e3478. Epub 2018 Oct 22.

Surgery, Jinnah Sindh Medical University, Karachi, PAK.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple systems by the process of inflammation and formation of auto-antibodies. When it presents in childhood, it is referred to as childhood systemic lupus erythematosus (cSLE). Cardiac tamponade is a rare but potentially lethal complication of cSLE, even rarer as an initial presentation. Read More

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http://dx.doi.org/10.7759/cureus.3478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318088PMC
October 2018
3 Reads

Therapy Side Effects in Systemic Lupus Erythematosus.

Curr Health Sci J 2018 Jul-Sep;44(3):316-321. Epub 2018 Jul 15.

Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.

Glucosteroids (GS) are widely used drugs for various inflammatory pathologies (Nephrotic syndrome, Proliferative glomerulonephritis, Extramembrane glomerulonephritis, Nephropathy of the Nodous Poliarterita (PAN), Nephropathy from purple Henoch-Schonlein, lupus nephropathy (LN), Acute adrenal insufficiency Waterhouse-Friederichsen, Chronic adrenal insufficiency Addison, Systemic Lupus Erythematosus (SLE), Polymyositis and dermatomyositis, Chronic granulomatosis, Crohn's disease, Hemorrhagic rectocolitis, Hemolytic anemias, Acute leukemias and chronic lymphocytic leukemia, Hodgkin's lymphoma). Although they are prescribed for their anti-inflammatory and immunosuppressive properties, they also have many side effects, hyperglycemia being one of the most common and representative, which is why these drugs need careful monitoring when administered over the long term. This paper presents the case of a 39 year old patient diagnosed with systemic lupus erythematosus (SLE) with class IV lupus nephropathy (LN) who developed numerous complications due to the pathogenic side effects: diabetes, amenorrhea, recurrent infections, and depression. Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311221PMC
July 2018
13 Reads

Haemophagocytic lymphohistiocytosis with collapsing lupus podocytopathy as an unusual manifestation of systemic lupus erythematosus with APOL1 double-risk alleles.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Division of Nephrology, Department of Medicine, Jacobi Medical Center at Albert Einstein College of Medicine, Bronx, New York, USA.

Haemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening syndrome caused by excessive immune activation. Secondary HLH has been described in autoimmune diseases. We detail the case of a 28-year-old African American woman who developed HLH in the setting of systemic lupus erythematosus with collapsing lupus podocytopathy superimposed on mesangial proliferative lupus nephritis class II. Read More

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http://dx.doi.org/10.1136/bcr-2018-227860DOI Listing
January 2019
3 Reads

Fulminant Guillain-Barré syndrome in a patient with systemic lupus erythematosus.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.

A 45-year-old man with a history of systemic lupus erythematosus presented with progressive weakness and areflexia. Electromyogram revealed reduced motor and sensory amplitudes without demyelinating features. He was clinically diagnosed with the acute motor and sensory axonal neuropathy variant of Guillain-Barré syndrome. Read More

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http://dx.doi.org/10.1136/bcr-2018-226634DOI Listing
January 2019
3 Reads

Pattern Recognition Receptors and Control of Innate Immunity: Role of Nucleic Acids.

Authors:
Silvia Fischer

Curr Pharm Biotechnol 2018 ;19(15):1203-1209

Institute of Biochemistry, Medical School, Justus-Liebig-University, Giessen 35392, Germany.

The innate immune system protects against infectious microbes by the recognition of pathogen- associated molecular patterns, which serve to detect pathogens on the host cell surface or in endosomes by pattern recognition receptors such as Toll-like receptors, nucleotide-binding oligomerization domain-containing protein-1-like receptors, mannose-receptor, or retinoic acid-inducible gene-1- like receptors that initiate proper host defense mechanisms. In addition to pathogen-associated molecular patterns, a series of endogenous danger-associated molecular patterns, such as nucleic acids, are recognized by pattern recognition receptors, which serve as body´s own alarm signals under sterile conditions, such as ischemic injuries, trauma, tumors, tissue transplants, or autoimmune diseases. Thus, exogenous as well as endogenous nucleic acids can function as "alarmins" to alert the body about danger or disease by triggering inflammation, dendritic cell maturation, and stimulate the immune response resulting in the release of cytokines, which in turn can augment the local inflammatory environment. Read More

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http://www.eurekaselect.com/168881/article
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http://dx.doi.org/10.2174/138920112804583087DOI Listing
April 2019
10 Reads

Seizure and Acute Vision Loss in a Filipino Lupus Patient: A Case of Posterior Reversible Encephalopathy Syndrome with Intraparenchymal Hemorrhage.

Case Rep Med 2018 9;2018:4238676. Epub 2018 Dec 9.

Section of Rheumatology, Department of Medicine, UP-Philippine General Hospital, Manila, Philippines.

Posterior reversible encephalopathy syndrome (PRES) is a rare and poorly understood neurologic condition that has been described in some patients with systemic lupus erythematosus (SLE). Intracerebral hemorrhage is a unique and atypical presentation of PRES and has been described only in a small number of patients with SLE. We present the case of a 33-year-old female, diagnosed with SLE and active nephritis, who was admitted for seizures. Read More

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https://www.hindawi.com/journals/crim/2018/4238676/
Publisher Site
http://dx.doi.org/10.1155/2018/4238676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304919PMC
December 2018
12 Reads

Acute Appendicitis in a Patient with Systemic Lupus Erythematosus.

Acta Med Indones 2018 Oct;50(4):332-335

Department of Internal Medicine, Faculty of Medicine, Airlanggan University - dr. Soetomo Hospital, Surabaya, Indonesia.

Systemic lupus erythematosus (SLE) is a chronic excacerbative autoimmune disease with wide clinical spectrum. Gastrointestinal manifestasion is a frequent clinical manifestasion seen in SLE. Management with glucocorticoid and non-steroid anti-inflammatory drugs (NSAID) can mask the gastrointestinal symptoms in patient with SLE. Read More

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October 2018
8 Reads

[Clinical and pathological characteristics and outcome of 46 children with autoimmune hepatitis].

Zhonghua Er Ke Za Zhi 2019 Jan;57(1):40-45

Pediatric Liver Diseases Treatment and Research Center, Fifth Medical Center, General Hospital of the People's Liberation Army (PLA), Beijing 100039, China.

To review and analyze the clinical and pathological data of children with autoimmune hepatitis (AIH). Medical records of 46 patients hospitalized in Pediatric Liver Diseases Treatment and Research Center, Fifth Medical Center, General Hospital of People's Liberation Army(PLA) from April 2012 to April 2018 were extracted. Medical data included type of AIH, clinical manifestations, biochemical parameters, liver biopsy results, and outcomes of treatment were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.01.010DOI Listing
January 2019
8 Reads

Munchausen by proxy syndrome mimicking childhood-onset systemic lupus erythematosus.

Lupus 2019 Feb 7;28(2):249-252. Epub 2019 Jan 7.

1 Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Childhood-onset systemic lupus erythematosus (cSLE) is a chronic inflammatory multisystem autoimmune disease that requires multiple differential diagnoses. Munchausen by proxy syndrome (MBPS) is a form of child abuse, where a caregiver intentionally creates a medical history and induces or fabricates signs or disease in a patient. To our knowledge, there is no case report of MBPS mimicking cSLE diagnosis. Read More

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http://dx.doi.org/10.1177/0961203318821156DOI Listing
February 2019
4 Reads

The clinical features and mortality risk factors of cytomegalovirus infection in patients with systemic lupus erythematosus.

J Microbiol Immunol Infect 2019 Feb 16;52(1):114-121. Epub 2018 Dec 16.

Division of Allergy, Immunology, & Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; National Yang-Ming University Faculty of Medicine, Taipei, Taiwan. Electronic address:

Background: The clinical features and outcomes of cytomegalovirus (CMV) diseases in patients with systemic lupus erythematosus (SLE) are unknown. We analyzed such data from a medical center in Taiwan.

Methods: We retrospectively reviewed the medical records of patients with SLE who were diagnosed with CMV diseases between 2006 and 2016 in Taipei Veterans General Hospital Taiwan. Read More

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http://dx.doi.org/10.1016/j.jmii.2018.12.002DOI Listing
February 2019
1 Read

Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival.

Liver Int 2018 Dec 29. Epub 2018 Dec 29.

Liver Unit, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.

Background: Several lines of evidence indicate that decompensated cirrhosis is characterized by the presence of systemic inflammation. Hepatorenal syndrome (HRS-AKI) is a unique type of renal failure that occurs at late stages of cirrhosis. However, confirmation of the presence and significance of such inflammatory response in HRS-AKI is lacking. Read More

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http://dx.doi.org/10.1111/liv.14037DOI Listing
December 2018
10 Reads