4,961 results match your criteria Lupus [Journal]


Renal transplantation for lupus nephritis: non-adherence and graft survival.

Lupus 2019 Apr 13:961203319842641. Epub 2019 Apr 13.

1 Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom.

Objectives: Poor adherence to immunosuppressive treatment is common in patients with systemic lupus erythematosus and may identify those with lupus nephritis (LN) who have a poorer prognosis. Non-adherence has also been reported to be a potential adverse outcome predictor in renal transplantation (rTp). We investigated whether non-adherence is associated with increased rTp graft rejection and/or failure in patients with LN. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/0961203319842641
Publisher Site
http://dx.doi.org/10.1177/0961203319842641DOI Listing
April 2019
1 Read

Combination immunosuppressant therapy and lupus nephritis outcome: a hospital-based study.

Lupus 2019 Apr 10:961203319842663. Epub 2019 Apr 10.

1 Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung.

Lupus nephritis (LN) is the leading cause of mortality in lupus patients. This study aimed to investigate the treatment outcome and renal histological risk factors of LN in a tertiary referral center. Between 2006 and 2017, a retrospective observational study enrolled 148 biopsy-proven LN patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319842663DOI Listing
April 2019
1 Read

Hydroxychloroquine treatment during pregnancy in lupus patients is associated with lower risk of preeclampsia.

Lupus 2019 Apr 10:961203319843343. Epub 2019 Apr 10.

1 Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Hydroxychloroquine (HCQ) is regarded as a mainstay in the treatment of systemic lupus erythematosus (SLE) because of its efficacy in preventing flares, achieving remission, and reducing overall mortality. However, the impact of HCQ on pregnancy outcomes remains controversial.

Objective: We aimed to investigate the effect of HCQ on pregnancy outcomes in patients with SLE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319843343DOI Listing
April 2019
4 Reads

Non-pharmacologic therapies for systemic lupus erythematosus.

Lupus 2019 Apr 8:961203319841435. Epub 2019 Apr 8.

3 Center for Complementary and Integrative Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA, USA.

Background: Non-pharmacologic therapies have been deemed as potentially beneficial for patients with systemic lupus erythematosus. We conducted an updated review to determine the effects of these therapies to inform practice.

Methods: A literature search was performed using PubMed (MEDLINE), EMBASE, Cochrane, PsychINFO, the Cumulative Index to Nursing and Allied Health Literature, Web of Science, and Google Scholar from inception until August 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319841435DOI Listing
April 2019
1 Read

Cyclophosphamide: similarities and differences in the treatment of SSc and SLE.

Lupus 2019 Apr 8:961203319840433. Epub 2019 Apr 8.

1 Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319840433DOI Listing

The essential role of costimulatory molecules in systemic lupus erythematosus.

Lupus 2019 Apr 5:961203319829818. Epub 2019 Apr 5.

2 Division of Rheumatology, Penn State College of Medicine and Milton S. Hershey Medical Center, Hershey, PA, USA.

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease with immune system disorder mediated through complex autoimmune pathways that involve immune cells, nonimmune cells, cytokines, chemokines, as well as costimulatory molecules. Costimulatory signals play a critical role in initiating, maintaining and regulating immune reactions, and these include ligands and receptors and their interactions involving multiple types of signal information. Dysfunction of costimulatory factors results in complicated abnormal immune responses, with biological effects and eventually, clinical autoimmune diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319829818DOI Listing

Stress fractures in systemic lupus erythematosus after long-term MTX use successfully treated by MTX discontinuation and individualized bone-specific therapy.

Lupus 2019 Apr 4:961203319841434. Epub 2019 Apr 4.

1 Department of Osteology and Biomechanics, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

We report the case of a 64-year-old woman with systemic lupus erythematosus (SLE) and recurrent bilateral stress fractures of the calcaneus due to long-term methotrexate (MTX) use. A detailed skeletal assessment pointed to osteoporomalacia with pronounced trabecular thinning and increased bone resorption. After years of unsuccessful treatment with bisphosphonates, a combined bone-specific denosumab-teriparatide treatment was initiated, and additional belimumab treatment was started to avoid intermittent steroid usage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319841434DOI Listing

Challenges of achieving clinical remission in a national cohort of juvenile-onset systemic lupus erythematosus patients.

Lupus 2019 Apr 3:961203319840699. Epub 2019 Apr 3.

1 Department of Paediatric Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Background And Objectives: The multisystem involvement and variable course of juvenile-onset systemic lupus erythematosus (JSLE) make it difficult to assess disease activity over time. International consensus definitions of inactive disease and clinical remission have been proposed. The aim of this study was to determine the proportion of patients meeting these criteria in a large national cohort of JSLE patients and the association between achieving inactive disease and clinical remission with disease activity at presentation and time to diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319840699DOI Listing
April 2019
2 Reads

Chinese Systemic Lupus Erythematosus Treatment and Research Group (CSTAR) Registry XI: gender impact on long-term outcomes.

Lupus 2019 Apr 2:961203319839845. Epub 2019 Apr 2.

1 Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Objective: The objective of this paper is to assess the role of gender on survival rate and causes of death and organ damage in systemic lupus erythematosus (SLE) patients in China from 2009 to 2015.

Methods: We conducted a multicenter cohort study to analyze the differences in outcome data between male and female SLE patients. A group of 1494 SLE patients who fulfilled the 1997 American College of Rheumatology SLE classification criteria were enrolled in the Chinese Systemic Lupus Erythematosus Treatment and Research Group (CSTAR) registry from April 2009 to February 2010. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319839845DOI Listing

A case with good response to belimumab for lupus nephritis complicated by IgG4-related disease.

Lupus 2019 Mar 27:961203319840430. Epub 2019 Mar 27.

1 Department of Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Immunoglobulin (Ig)G4-related disease (IgG4-RD) is an unusual complication of systemic lupus erythematosus (SLE). We report a case in which belimumab proved efficacious for not only SLE, but also IgG4-RD. A 58-year-old Japanese woman had suffered from photodermatosis and erythema on the limbs for 20 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319840430DOI Listing
March 2019
1 Read

CD44v3 and CD44v6 isoforms on T cells are able to discriminate different disease activity degrees and phenotypes in systemic lupus erythematosus patients.

Lupus 2019 Mar 24:961203319838063. Epub 2019 Mar 24.

1 Lupus Clinic, Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

Background: Adhesion molecule CD44 contributes to T cell migration into target organs. A higher expression of CD44v3 and v6 isoforms has been identified on T cells from systemic lupus erythematosus (SLE) patients. The aim of this study was to investigate the expression of CD44v3/v6 on T cells of SLE patients in order to evaluate their correlation with clinical features. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319838063DOI Listing
March 2019
1 Read

Successful conception in a 34-year-old lupus patient following spontaneous pregnancy after autotransplantation of cryopreserved ovarian tissue.

Lupus 2019 Mar 24:961203319839482. Epub 2019 Mar 24.

3 UniCareD, University Cryobank for Assisted Reproductive Medicine and Fertility Protection at UniKiD Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.

Premature gonadal failure is a common problem in patients with systemic lupus erythematosus (SLE) when gonadotoxic therapies are applied. The preservation of gonadal function and fertility is of great importance to many predominantly young SLE patients. Some fertility preservation methods are well established and well known, whereas others are considered more cautiously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319839482DOI Listing
March 2019
1 Read

Left ventricular pseudoaneurysm associated with systemic lupus erythematosus.

Lupus 2019 Mar 24:961203319837359. Epub 2019 Mar 24.

1 Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Systemic lupus erythematosus (SLE) is associated with several cardiac manifestations but, to our knowledge, there have been no previously published reports on left ventricular (LV) pseudoaneurysm in this disease. We describe a case of a 30-year-old woman with SLE who presented with a disease flare (acute and subacute cutaneous lupus, pericarditis, fever, leukopenia) associated with heart failure syndrome. The patient was diagnosed with a large LV pseudoaneurysm and a bovine pericardium patch closure was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319837359DOI Listing
March 2019
2 Reads

Self-management and adherence in childhood-onset systemic lupus erythematosus: what are we missing?

Lupus 2019 Mar 24:961203319839478. Epub 2019 Mar 24.

2 Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Objectives: The aims of this study are (1) to characterize factors influencing self-management behaviors and quality of life in adolescent and young adult (AYA) patients with childhood-onset systemic lupus erythematosus (cSLE) and (2) to identify barriers and facilitators of treatment adherence via focus groups.

Methods: AYAs with cSLE ages 12-24 years and primary caregivers of the adolescents participated in this study. Recruitment occurred during pediatric rheumatology clinic visits at a Midwestern children's hospital or the hospital's cSLE active clinic registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319839478DOI Listing
March 2019
1 Read

Performance of SLEDAI-2K to detect a clinically meaningful change in SLE disease activity: a 36-month prospective cohort study of 334 patients.

Lupus 2019 Mar 21:961203319836717. Epub 2019 Mar 21.

1 Rheumatology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Objective: The objective of this paper is to evaluate the performance of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI-2K) in detecting clinically meaningful changes in SLE disease activity.

Methods: A longitudinal cohort study was conducted of 334 SLE patients during a 36-month follow-up. At each outpatient visit, disease activity was scored using the Physician Global Assessment (PGA) and SLEDAI-2K. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319836717DOI Listing
March 2019
1 Read

Three-dimensional echocardiographic evaluation of the right ventricle in patients with uncomplicated systemic lupus erythematosus.

Lupus 2019 Apr 18;28(4):538-544. Epub 2019 Mar 18.

2 Department of Translational Medical Sciences, Federico II University Hospital, Naples, Italy.

Our aim was to identify subclinical right ventricular (RV) alterations in systemic lupus erythematosus (SLE) by combining standard and three-dimensional echocardiography (3DE). Fifty SLE patients without concomitant cardiac disease and 50 healthy controls, matched for age and gender, were enrolled. Disease damage was evaluated by inflammatory markers and SLE damage index. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319833786DOI Listing
April 2019
1 Read

RNA-seq of circular RNAs identified circPTPN22 as a potential new activity indicator in systemic lupus erythematosus.

Lupus 2019 Apr 14;28(4):520-528. Epub 2019 Mar 14.

1 Department of Dermatology, the 901th Hospital Affiliated to Anhui Medical University, Hefei, China.

Background: Circular RNAs (circRNAs) are possible biomarkers for many diseases, but the knowledge of circRNAs in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE) remains limited. This study aimed to assess the expression of circRNAs in PBMCs from patients with SLE and healthy individuals by RNA sequencing (RNA-seq).

Methods: In total, 128 circRNAs were significantly differentially expressed including 39 upregulated and 89 downregulated circRNAs in four new-onset SLE patients compared with three healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319830493DOI Listing
April 2019
1 Read

Outcomes following mycophenolate mofetil versus cyclophosphamide induction treatment for proliferative juvenile-onset lupus nephritis.

Lupus 2019 Mar 14:961203319836712. Epub 2019 Mar 14.

1 Department of Women and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Background: Juvenile-onset systemic lupus erythematosus (JSLE) is more severe than adult-onset disease, including more lupus nephritis (LN). Despite differences in phenotype/pathogenesis, treatment is based upon adult trials. This study aimed to compare treatment response, damage accrual, time to inactive LN and subsequent flare, in JSLE LN patients treated with mycophenolate mofetil (MMF) versus intravenous cyclophosphamide (IVCYC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319836712DOI Listing
March 2019
4 Reads

Belimumab in refractory organizing pneumonia associated with systemic lupus erythematosus: a case report.

Lupus 2019 Apr 12;28(4):565-568. Epub 2019 Mar 12.

5 Department of Pathology, Ciudad Real University General Hospital, Ciudad Real, Spain.

Organizing pneumonia is an inflammatory lung entity that presents with a huge variety of clinical, radiological and pathological patterns. Organizing pneumonia can be idiopathic or secondary to other diseases. Corticosteroid therapy is usually the first-line treatment showing clinical improvement in most cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319835320DOI Listing

Impact of functional IL-18 polymorphisms on genetic predisposition and diverse clinical manifestations of the disease in Indian SLE patients.

Lupus 2019 Apr 11;28(4):545-554. Epub 2019 Mar 11.

1 National Institute of Immunohaematology, Indian Council of Medical Research, Mumbai, India.

Several studies have demonstrated associations between interleukin-18 polymorphisms and risk of systemic lupus erythematosus in different populations except one of Indian origin. We therefore investigated for the influence of interleukin-18 (-1297T/C, -607A/C, -137G/C; + 105A/C) polymorphisms on genetic susceptibility and clinical expression of the disease in Indian systemic lupus erythematosus patients. A total of 200 systemic lupus erythematosus patients and 201 controls were recruited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319834677DOI Listing
April 2019
2 Reads

Screening characteristics for enrichment of individuals at higher risk for transitioning to classified SLE.

Lupus 2019 Mar 7:961203319834675. Epub 2019 Mar 7.

1 Department of Epidemiology, Colorado School of Public Health, Aurora, United States of America.

Objective: Further prospective study is needed to elucidate the etiology and natural history of systemic lupus erythematosus development. The clinical complexity of this heterogeneous disease makes study design challenging. Our objective was to ascertain useful screening factors for identifying at-risk individuals for follow-up rheumatologic assessment or inclusion in prospective studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319834675DOI Listing

Ultrasound in the assessment of musculoskeletal involvement in systemic lupus erythematosus: state of the art and perspectives.

Lupus 2019 Mar 6:961203319834671. Epub 2019 Mar 6.

1 Department of Clinical and Molecular Sciences, Rheumatology Unit, Polytechnic University of Marche, Ancona, Italy.

Musculoskeletal manifestations are extremely common in patients with systemic lupus erythematosus. Transient and migratory arthralgia is frequently reported even without clinical signs of joint or tendon inflammation. In less than 15% of patients, joints may be more severely affected by deforming (Jaccoud's arthropathy) and/or erosive arthropathy (Rhupus syndrome). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319834671DOI Listing
March 2019
1 Read

Induced expression of Toll-like receptor 9 in peritubular capillary endothelium correlates with the progression of tubulointerstitial lesions in autoimmune disease-prone mice.

Lupus 2019 Mar 10;28(3):324-333. Epub 2019 Feb 10.

1 Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Background: Toll-like receptor (Tlr) 9 is capable of recognizing exogenous and/or endogenous nucleic acids and plays a crucial role in innate and adaptive immunity. Recently, we showed that Tlr9 is overexpressed in podocytes, a component of the blood-urine barrier (BUB), in glomeruli of autoimmune glomerulonephritis (AGN) model mice. This study investigated the activation of peritubular capillary (PTC) endothelial cells (ECs), a component of the BUB in the tubulointerstitium, through overexpressing Tlr9, and the subsequent development of tubulointerstitial lesions (TILs) in AGN model mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828518DOI Listing

The impact of SLE on health-related quality of life assessed with SF-36: a systemic review and meta-analysis.

Lupus 2019 Mar;28(3):371-382

1 Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, China.

Objective: To evaluate the impact of systemic lupus erythematosus (SLE) on health-related quality of life (HRQoL) assessed with SF-36 and explore factors associated with HRQoL in SLE patients.

Methods: A random-effect meta-analysis was performed to calculate extracted data. Sensitivity and subgroup analyses were performed to distinguish sources of heterogeneity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828519DOI Listing

Anti-α-enolase antibody combined with β2 microglobulin evaluated the incidence of nephritis in systemic lupus erythematosus patients.

Lupus 2019 Mar;28(3):365-370

1 Department of Laboratory Medicine, Sun Yat-sen University affiliated Zhongshan Hospital, Zhongshan, China.

Objective: Anti-α-enolase antibody (Ab) combined with β2 microglobulin (β2-MG) were investigated to predict the incidence of nephritis in systemic lupus erythematosus (SLE) patients.

Methods: Levels of serum anti-α-enolase Ab and urinary β2-MG were detected in 115 SLE patients, 29 SLE patients with nephritis and 70 healthy controls by ELISA and immunoturbidimetry, respectively. Furthermore, the correlation between anti-α-enolase Ab combined with β2-MG and the incidence of nephritis in SLE patients was evaluated by correlation analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828822DOI Listing
March 2019
1 Read

Not only disease activity but also chronic hypertension and overweight are determinants of pregnancy outcomes in patients with systemic lupus erythematosus.

Lupus 2019 Apr 24;28(4):529-537. Epub 2019 Feb 24.

1 Department of Nephrology, Hypertension and Dialysis, Hospices Civils de Lyon, Lyon, France.

Introduction: Pregnancies in women with lupus nephritis are at high-risk of complications, while scarcity of scientific knowledge on prognostic factors impedes a fair medical counseling. We aimed to identify determinants associated with maternal and fetal complications.

Materials: We retrospectively reviewed medical charts of pregnancies that lasted more than 22 weeks in 66 patients with pre-existing lupus nephritis between 2004 and 2013 in France. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319832097DOI Listing
April 2019
1 Read

Uveal effusion and transient myopia as the initial presentation of systemic lupus erythematosus patient with pulmonary arterial hypertension: case report.

Lupus 2019 Apr 21;28(4):560-564. Epub 2019 Feb 21.

Department of Ophthalmology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

We reported uveal effusion and transient myopia as the initial presentation of systemic lupus erythematosus with pulmonary arterial hypertension. Choroidal retinopathy is rare but extremely destructive to visual function. Therefore, prompt diagnosis and effective treatments will result in complete resolution of the uveal effusion and functional restoration of vision. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319829819DOI Listing
April 2019
1 Read

The impact of different classes of lupus nephritis on maternal and fetal outcomes: a cohort study of 147 pregnancies.

Lupus 2019 Apr 18;28(4):492-500. Epub 2019 Feb 18.

2 Department of Rheumatology, State University of Rio de Janeiro, Brazil.

Objective: To analyze the impact of different classes of lupus nephritis as risk variables for maternal and fetal adverse outcomes in a cohort of pregnant lupus patients.

Methods: This is a cohort study with retrospective and prospective data collection, conducted at the University Hospital of State University of Rio de Janeiro, Brazil, from 2011 to 2016. A total of 147 pregnancies of 137 systemic lupus erythematosus patients of whom 66 had lupus nephritis were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319829825DOI Listing
April 2019
1 Read

Genetic polymorphisms near IL-21 gene associated with Th17 cytokines confer risk for systemic lupus erythematosus in Chinese Han population.

Lupus 2019 Mar 18;28(3):406-413. Epub 2019 Feb 18.

1 Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.

Objective: Interleukin-21 (IL-21) contributes to expansion, differentiation, and modulation of various immunocompetent cells. Deregulated production of IL-21 plays a role of cardinal significance in the pathogenesis of systemic lupus erythematosus (SLE). We aimed to determine whether single nucleotide polymorphisms (SNP) near the IL-21 gene have significant association with SLE susceptibility and the T helper-related inflammatory cytokine profile of SLE patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319829821DOI Listing
March 2019
4 Reads

Antibodies to M-type phospholipase A2 receptor (PLAR) in membranous lupus nephritis.

Lupus 2019 Mar 13;28(3):396-405. Epub 2019 Feb 13.

1 Department of Medicine, Systemic Autoimmune Diseases Unit, Hospital Universitari Vall d'Hebrón, Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Antibodies to M-type phospholipase A2 receptor (a-PLAR) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was to assess the prevalence of a-PLAR antibodies in a large cohort of patients with lupus nephritis.

Methods: a-PLAR antibodies were measured by ELISA in serum from patients with systemic lupus erythematosus ( n = 190), of whom 37 had a biopsy-proven MLN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828521DOI Listing
March 2019
23 Reads

Downregulation of miR-633 activated AKT/mTOR pathway by targeting AKT1 in lupus CD4 T cells.

Lupus 2019 Apr 13;28(4):510-519. Epub 2019 Feb 13.

1 Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Accumulating evidence suggests that the AKT/mTOR pathway plays an important role in the pathogenesis of systemic lupus erythematosus (SLE) through activating T cells, and there are few studies looking into the role of microRNA (miRNAs) in the mechanism. We first found that miR-633 expression in CD4T cells of SLE patients was significantly reduced.

Objective: To investigate the role of miR-633 in the AKT/mTOR pathway in lupus CD4T cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319829853DOI Listing
April 2019
1 Read

Complete renal response at 12 months after induction therapy is associated with renal relapse-free rate in lupus nephritis: a single-center, retrospective cohort study.

Lupus 2019 Apr 12;28(4):501-509. Epub 2019 Feb 12.

1 Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Background: Lupus nephritis (LN) is a major risk factor for overall morbidity and mortality in systemic lupus erythematosus (SLE).

Methods: We retrospectively analyzed cases of proliferative and membranous LN patients who underwent a renal biopsy at our hospital in 1993-2016. We analyzed the association between complete renal response (CR) rates at 12 months after induction therapy and predictive factors for CR and their association with renal flares. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319829827DOI Listing
April 2019
1 Read

The associations of endothelial and podocyte injury in proliferative lupus nephritis: from observational analysis to in vitro study.

Lupus 2019 Mar 12;28(3):347-358. Epub 2019 Feb 12.

1 Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China.

Our study aims to evaluate the endothelial cell-podocyte crosstalk in proliferative lupus nephritis (LN). The semi-quantification scores of glomerular endothelial cell injury and the foot process width (FPW) were processed in 110 proliferative LN patients. Podocytes were stimulated with LN-derived IgG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828509DOI Listing
March 2019
1 Read

Transcranial Doppler findings in antiphospholipid syndrome.

Lupus 2019 Apr 12;28(4):483-491. Epub 2019 Feb 12.

1 Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.

Introduction: Transcranial Doppler is a method that enables the assessment of different cerebral hemodynamic parameters. It also allows for the evaluation of the presence of right-to-left circulation shunts (RLS) and for the detection of microembolic signals (MESs), which might be associated with an increased risk of cerebrovascular events. For instance, the presence of MESs on transcranial Doppler in patients with systemic lupus erythematous (SLE) and antiphospholipid syndrome (APS) is associated with an increased risk of stroke. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828833DOI Listing
April 2019
1 Read

Choroid thickness profile in patients with lupus nephritis.

Lupus 2019 Apr 12;28(4):475-482. Epub 2019 Feb 12.

1 Centro Hospitalar de Vila Nova de Gaia Espinho, Vila Nova de Gaia, Portugal.

Background: Choroidopathy is a rare manifestation of systemic lupus erythematosus (SLE). This entity is associated with active phases of severe SLE and it is frequently accompanied by acute kidney failure, central nervous system involvement and coagulopathy.

Purpose: To evaluate the choroid thickness of patients with lupus nephritis (LN) without choroidopathy, and to compare this with that of age-matched SLE patients without LN and healthy control subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828525DOI Listing
April 2019
1 Read

Refractory lupus nephritis: a survey.

Lupus 2019 Apr 12;28(4):455-464. Epub 2019 Feb 12.

Medizinische Klinik and Poliklinik IV, Klinikum der Universität München, Munich, Germany.

'Refractory lupus nephritis' is a frequently used term but poorly defined. We conducted a survey among nephrologists and rheumatologists to spot the diversity of perceptions of this term and to better understand the clinical practice related to 'refractory lupus nephritis'. A total of 145 questionnaires completed by lupus nephritis experts were available for analysis, of which 52% were nephrologists, 34% rheumatologists, and 13% internists. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/0961203319828516
Publisher Site
http://dx.doi.org/10.1177/0961203319828516DOI Listing
April 2019
14 Reads

Evolution of retinal changes measured by optical coherence tomography in the assessment of hydroxychloroquine ocular safety in patients with systemic lupus erythematosus.

Lupus 2019 Apr 12;28(4):555-559. Epub 2019 Feb 12.

1 Autoimmune Diseases Research Unit, Department of Internal Medicine, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, University of The Basque Country, Bizkaia, Basque Country, Spain.

Objective: The objective of this report is to analyse retinal changes over a five-year period, assessed by spectral domain-optical coherence tomography (SD-OCT), in patients from the Lupus-Cruces cohort treated with hydroxychloroquine (HCQ).

Methods: SD-OCT screening was performed annually between 2012 and 2017. Average macular thickness (AMT), ganglion cell layer thickness (GCLT) and qualitative data of retinal pigment epithelium (RPE) and external retina (ExtR) were collected prospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319829826DOI Listing
April 2019
1 Read

Regulatory T-cell levels in systemic lupus erythematosus patients: a meta-analysis.

Lupus 2019 Apr 11;28(4):445-454. Epub 2019 Feb 11.

Department of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: The contribution of regulatory T-cells (Tregs) to systemic lupus erythematosus (SLE) pathogenesis remains a matter of debate. The objective of this study was to quantify the association between peripheral blood Tregs and disease status in SLE patients.

Method: EMBASE and PubMed databases were searched using 'systemic lupus erythematosus' and 'regulatory T-cells' as relevant key terms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828530DOI Listing
April 2019
8 Reads

Genomewide analysis of 6-methyladenine DNA in peripheral blood mononuclear cells of systemic lupus erythematosus.

Lupus 2019 Mar 11;28(3):359-364. Epub 2019 Feb 11.

2 Clinical Medical Research Center, The Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, Shenzhen, Guangdong, China.

Aim: The aim of this paper is to explore the expression of 6-methyladenine (6mA) DNA and to elucidate its gene regulation role in systemic lupus erythematosus (SLE).

Methods: Twenty SLE patients and 20 normal control healthy individuals (HCs) were included in this study. Genomic DNA was isolated from peripheral blood mononuclear cells and subsequently underwent 6mA-immunoprecipitation-sequencing (6mA-IP-Seq) after DNA quality control and 6mA precipitation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828520DOI Listing
March 2019
1 Read

Infectious complications in lupus nephritis treatment: a systematic review and meta-analysis.

Authors:
K M Thong T M Chan

Lupus 2019 Mar 11;28(3):334-346. Epub 2019 Feb 11.

1 Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.

Objectives: Infection is an important concern in lupus nephritis treatment, but few studies have focused on this complication. Available data suggest marked variation in occurrence and outcome. This meta-analysis and review aims to provide an overview of infective complications, focusing on the risk factors and outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319829817DOI Listing
March 2019
1 Read

Utility of osteopontin in cerebrospinal fluid as a diagnostic marker for neuropsychiatric systemic lupus erythematosus.

Lupus 2019 Mar 11;28(3):414-422. Epub 2019 Feb 11.

1 Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The whole protein of osteopontin (OPN full) and its cleaved form (OPN N-half) are involved in the immune response and the migration of immune cells to an inflammatory lesion. We have reported that serum OPN full and urine OPN N-half are elevated in lupus nephritis (LN). Neuropsychiatric systemic lupus erythematosus (NPSLE) is a refractory complication of SLE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828818DOI Listing
March 2019
1 Read

Usefulness of composite indices in the assessment of joint involvement in systemic lupus erythematosus patients: correlation with ultrasonographic score.

Lupus 2019 Mar 11;28(3):383-388. Epub 2019 Feb 11.

Lupus Clinic, Reumatologia, Dipartimento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Viale del Policlinico 155 - 00161 Rome, Italy.

Specific indices are not available to evaluate systemic lupus erythematosus (SLE) joint involvement; indeed, the application of indices validated for rheumatoid arthritis has been suggested. We evaluated the usefulness of organ specific composite indices, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828527DOI Listing
March 2019
6 Reads

Effect of pericardial effusion on outcomes in children admitted with systemic lupus erythematosus: a multicenter retrospective cohort study from the United States.

Lupus 2019 Mar 11;28(3):389-395. Epub 2019 Feb 11.

1 University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock AR, USA.

Objective: We sought to describe characteristics of children admitted with pericardial effusion (PCE) and systemic lupus erythematosus (SLE) and determine the association between PCE and outcomes of interest.

Methods: We performed a retrospective cohort study of the Pediatric Health Information System (PHIS). Patients were included if they were admitted to a PHIS participating hospital from 2004 to 2015 with a diagnosis of SLE and age ≤18 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828523DOI Listing
March 2019
1 Read

Incidence and predictors of aorta calcification in patients with systemic lupus erythematosus.

Lupus 2019 Mar 10;28(3):275-282. Epub 2019 Feb 10.

1 Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P.R. China.

Objective: Artery calcification, as subclinical atherosclerosis, is attracting attention. The aim of this study was to determine the prevalence and risk factors of artery calcification in patients with systemic lupus erythematosus.

Methods: 641 patients with systemic lupus erythematosus were enrolled in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319826689DOI Listing
March 2019
1 Read

Peripheral nervous system involvement in systemic lupus erythematosus: a retrospective study on prevalence, associated factors and outcome.

Lupus 2019 Apr 10;28(4):465-474. Epub 2019 Feb 10.

1 Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S. Anna, Cona (Ferrara), Italy.

Background: Despite its potentially significant impact on disease outcome, peripheral nervous system involvement in systemic lupus erythematosus has received little attention.

Objective: The objective of this study was to assess the prevalence and clinical features of peripheral nervous system involvement in a large cohort of systemic lupus erythematosus patients.

Methods: The records of systemic lupus erythematosus patients examined at two tertiary referral centres over a period of 14 years (from 2000 to 2014) were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828499DOI Listing
April 2019
1 Read

Pulmonary hypertension in lupus.

Lupus 2019 Mar 10;28(3):440-441. Epub 2019 Feb 10.

Internal Medicine Department, Hospital Universitario La Paz, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319827653DOI Listing
March 2019
5 Reads

Levels of anti-Müllerian hormone in premenopausal women with the antiphospholipid syndrome and its association with the risk of clinical complications.

Lupus 2019 Mar 4;28(3):427-431. Epub 2019 Feb 4.

3 Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

Objective: The study aims to investigate the ovarian reserve in premenopausal women with antiphospholipid syndrome (APS) and to evaluate whether it is associated with cumulative organ damage or the risk of clinical complications.

Methods: This single-center study was conducted in 23 premenopausal female patients (10 with primary APS and 13 with secondary APS) and 24 healthy volunteers. Serum anti-Müllerian hormone (AMH) levels were measured by enzyme-linked immunoassay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319828507DOI Listing
March 2019
1 Read

Systemic lupus erythematosus is a risk factor for cancer: a nationwide population-based study in Korea.

Lupus 2019 Mar 2;28(3):317-323. Epub 2019 Feb 2.

1 Department of Internal Medicine, Chonnam National University Medical School, Gwangju.

Objective: Specific differences in cancer risk have been observed between systemic lupus erythematosus patients and the general population. Although meta-analyses have estimated cancer incidence in systemic lupus erythematosus patients, results have been inconclusive. Hence, we aimed to assess malignancy risk in systemic lupus erythematosus patients, compared to the risk in the general population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319826672DOI Listing
March 2019
3 Reads

Peripheral neutrophil CD64 index combined with complement, CRP, WBC count and B cells improves the ability of diagnosing bacterial infection in SLE.

Lupus 2019 Mar 2;28(3):304-316. Epub 2019 Feb 2.

3 Department of Rheumatology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Objective: To investigate the diagnostic role of complement C3, complement C4, C-reactive protein (CRP), procalcitonin (PCT), white blood cell count (WBC), neutrophil CD64 (nCD64) index, lymphocyte subsets and their combination in differentiating bacterial infection from disease relapse in systemic lupus erythematosus (SLE).

Methods: The above biomarkers in 36 hospitalized SLE patients with bacterial infection and 45 with lupus flare without infection were retrospectively studied. Bacterial infection was proven by positive cultures or typical clinical symptoms and signs combined with positive response to antibiotics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319827646DOI Listing
March 2019
2 Reads