4,935 results match your criteria Lupus [Journal]


Uveal effusion and transient myopia as the initial presentation of systemic lupus erythematosus patient with pulmonary arterial hypertension: case report.

Lupus 2019 Feb 21:961203319829819. Epub 2019 Feb 21.

Department of Ophthalmology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

We reported uveal effusion and transient myopia as the initial presentation of systemic lupus erythematosus with pulmonary arterial hypertension. Choroidal retinopathy is rare but extremely destructive to visual function. Therefore, prompt diagnosis and effective treatments will result in complete resolution of the uveal effusion and functional restoration of vision. Read More

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http://dx.doi.org/10.1177/0961203319829819DOI Listing
February 2019

The impact of different classes of lupus nephritis on maternal and fetal outcomes: a cohort study of 147 pregnancies.

Lupus 2019 Feb 18:961203319829825. Epub 2019 Feb 18.

2 Department of Rheumatology, State University of Rio de Janeiro, Brazil.

Objective: To analyze the impact of different classes of lupus nephritis as risk variables for maternal and fetal adverse outcomes in a cohort of pregnant lupus patients.

Methods: This is a cohort study with retrospective and prospective data collection, conducted at the University Hospital of State University of Rio de Janeiro, Brazil, from 2011 to 2016. A total of 147 pregnancies of 137 systemic lupus erythematosus patients of whom 66 had lupus nephritis were included. Read More

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http://dx.doi.org/10.1177/0961203319829825DOI Listing
February 2019

Genetic polymorphisms near IL-21 gene associated with Th17 cytokines confer risk for systemic lupus erythematosus in Chinese Han population.

Lupus 2019 Feb 18:961203319829821. Epub 2019 Feb 18.

1 Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.

Objective: Interleukin-21 (IL-21) contributes to expansion, differentiation, and modulation of various immunocompetent cells. Deregulated production of IL-21 plays a role of cardinal significance in the pathogenesis of systemic lupus erythematosus (SLE). We aimed to determine whether single nucleotide polymorphisms (SNP) near the IL-21 gene have significant association with SLE susceptibility and the T helper-related inflammatory cytokine profile of SLE patients. Read More

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http://dx.doi.org/10.1177/0961203319829821DOI Listing
February 2019

Antibodies to M-type phospholipase A2 receptor (PLAR) in membranous lupus nephritis.

Lupus 2019 Feb 13:961203319828521. Epub 2019 Feb 13.

1 Department of Medicine, Systemic Autoimmune Diseases Unit, Hospital Universitari Vall d'Hebrón, Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Antibodies to M-type phospholipase A2 receptor (a-PLAR) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was to assess the prevalence of a-PLAR antibodies in a large cohort of patients with lupus nephritis.

Methods: a-PLAR antibodies were measured by ELISA in serum from patients with systemic lupus erythematosus ( n = 190), of whom 37 had a biopsy-proven MLN. Read More

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http://dx.doi.org/10.1177/0961203319828521DOI Listing
February 2019
6 Reads

Downregulation of miR-633 activated AKT/mTOR pathway by targeting AKT1 in lupus CD4 T cells.

Lupus 2019 Feb 13:961203319829853. Epub 2019 Feb 13.

1 Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Accumulating evidence suggests that the AKT/mTOR pathway plays an important role in the pathogenesis of systemic lupus erythematosus (SLE) through activating T cells, and there are few studies looking into the role of microRNA (miRNAs) in the mechanism. We first found that miR-633 expression in CD4T cells of SLE patients was significantly reduced.

Objective: To investigate the role of miR-633 in the AKT/mTOR pathway in lupus CD4T cells. Read More

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http://dx.doi.org/10.1177/0961203319829853DOI Listing
February 2019
1 Read

Complete renal response at 12 months after induction therapy is associated with renal relapse-free rate in lupus nephritis: a single-center, retrospective cohort study.

Lupus 2019 Feb 12:961203319829827. Epub 2019 Feb 12.

1 Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Background: Lupus nephritis (LN) is a major risk factor for overall morbidity and mortality in systemic lupus erythematosus (SLE).

Methods: We retrospectively analyzed cases of proliferative and membranous LN patients who underwent a renal biopsy at our hospital in 1993-2016. We analyzed the association between complete renal response (CR) rates at 12 months after induction therapy and predictive factors for CR and their association with renal flares. Read More

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http://dx.doi.org/10.1177/0961203319829827DOI Listing
February 2019
1 Read

The associations of endothelial and podocyte injury in proliferative lupus nephritis: from observational analysis to in vitro study.

Lupus 2019 Feb 12:961203319828509. Epub 2019 Feb 12.

1 Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China.

Our study aims to evaluate the endothelial cell-podocyte crosstalk in proliferative lupus nephritis (LN). The semi-quantification scores of glomerular endothelial cell injury and the foot process width (FPW) were processed in 110 proliferative LN patients. Podocytes were stimulated with LN-derived IgG. Read More

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http://dx.doi.org/10.1177/0961203319828509DOI Listing
February 2019
1 Read

Transcranial Doppler findings in antiphospholipid syndrome.

Lupus 2019 Feb 12:961203319828833. Epub 2019 Feb 12.

1 Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.

Introduction: Transcranial Doppler is a method that enables the assessment of different cerebral hemodynamic parameters. It also allows for the evaluation of the presence of right-to-left circulation shunts (RLS) and for the detection of microembolic signals (MESs), which might be associated with an increased risk of cerebrovascular events. For instance, the presence of MESs on transcranial Doppler in patients with systemic lupus erythematous (SLE) and antiphospholipid syndrome (APS) is associated with an increased risk of stroke. Read More

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http://dx.doi.org/10.1177/0961203319828833DOI Listing
February 2019
1 Read

Choroid thickness profile in patients with lupus nephritis.

Lupus 2019 Feb 12:961203319828525. Epub 2019 Feb 12.

1 Centro Hospitalar de Vila Nova de Gaia Espinho, Vila Nova de Gaia, Portugal.

Background: Choroidopathy is a rare manifestation of systemic lupus erythematosus (SLE). This entity is associated with active phases of severe SLE and it is frequently accompanied by acute kidney failure, central nervous system involvement and coagulopathy.

Purpose: To evaluate the choroid thickness of patients with lupus nephritis (LN) without choroidopathy, and to compare this with that of age-matched SLE patients without LN and healthy control subjects. Read More

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http://dx.doi.org/10.1177/0961203319828525DOI Listing
February 2019
1 Read

Refractory lupus nephritis: a survey.

Lupus 2019 Feb 12:961203319828516. Epub 2019 Feb 12.

Medizinische Klinik and Poliklinik IV, Klinikum der Universität München, Munich, Germany.

'Refractory lupus nephritis' is a frequently used term but poorly defined. We conducted a survey among nephrologists and rheumatologists to spot the diversity of perceptions of this term and to better understand the clinical practice related to 'refractory lupus nephritis'. A total of 145 questionnaires completed by lupus nephritis experts were available for analysis, of which 52% were nephrologists, 34% rheumatologists, and 13% internists. Read More

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http://journals.sagepub.com/doi/10.1177/0961203319828516
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http://dx.doi.org/10.1177/0961203319828516DOI Listing
February 2019
2 Reads

Evolution of retinal changes measured by optical coherence tomography in the assessment of hydroxychloroquine ocular safety in patients with systemic lupus erythematosus.

Lupus 2019 Feb 12:961203319829826. Epub 2019 Feb 12.

1 Autoimmune Diseases Research Unit, Department of Internal Medicine, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, University of The Basque Country, Bizkaia, Basque Country, Spain.

Objective: The objective of this report is to analyse retinal changes over a five-year period, assessed by spectral domain-optical coherence tomography (SD-OCT), in patients from the Lupus-Cruces cohort treated with hydroxychloroquine (HCQ).

Methods: SD-OCT screening was performed annually between 2012 and 2017. Average macular thickness (AMT), ganglion cell layer thickness (GCLT) and qualitative data of retinal pigment epithelium (RPE) and external retina (ExtR) were collected prospectively. Read More

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http://dx.doi.org/10.1177/0961203319829826DOI Listing
February 2019
1 Read

Regulatory T-cell levels in systemic lupus erythematosus patients: a meta-analysis.

Lupus 2019 Feb 11:961203319828530. Epub 2019 Feb 11.

Department of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: The contribution of regulatory T-cells (Tregs) to systemic lupus erythematosus (SLE) pathogenesis remains a matter of debate. The objective of this study was to quantify the association between peripheral blood Tregs and disease status in SLE patients.

Method: EMBASE and PubMed databases were searched using 'systemic lupus erythematosus' and 'regulatory T-cells' as relevant key terms. Read More

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http://dx.doi.org/10.1177/0961203319828530DOI Listing
February 2019
1 Read

Genomewide analysis of 6-methyladenine DNA in peripheral blood mononuclear cells of systemic lupus erythematosus.

Lupus 2019 Feb 11:961203319828520. Epub 2019 Feb 11.

2 Clinical Medical Research Center, The Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, Shenzhen, Guangdong, China.

Aim: The aim of this paper is to explore the expression of 6-methyladenine (6mA) DNA and to elucidate its gene regulation role in systemic lupus erythematosus (SLE).

Methods: Twenty SLE patients and 20 normal control healthy individuals (HCs) were included in this study. Genomic DNA was isolated from peripheral blood mononuclear cells and subsequently underwent 6mA-immunoprecipitation-sequencing (6mA-IP-Seq) after DNA quality control and 6mA precipitation. Read More

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http://dx.doi.org/10.1177/0961203319828520DOI Listing
February 2019
1 Read

Infectious complications in lupus nephritis treatment: a systematic review and meta-analysis.

Authors:
K M Thong T M Chan

Lupus 2019 Feb 11:961203319829817. Epub 2019 Feb 11.

1 Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.

Objectives: Infection is an important concern in lupus nephritis treatment, but few studies have focused on this complication. Available data suggest marked variation in occurrence and outcome. This meta-analysis and review aims to provide an overview of infective complications, focusing on the risk factors and outcomes. Read More

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http://dx.doi.org/10.1177/0961203319829817DOI Listing
February 2019
1 Read

Utility of osteopontin in cerebrospinal fluid as a diagnostic marker for neuropsychiatric systemic lupus erythematosus.

Lupus 2019 Feb 11:961203319828818. Epub 2019 Feb 11.

1 Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The whole protein of osteopontin (OPN full) and its cleaved form (OPN N-half) are involved in the immune response and the migration of immune cells to an inflammatory lesion. We have reported that serum OPN full and urine OPN N-half are elevated in lupus nephritis (LN). Neuropsychiatric systemic lupus erythematosus (NPSLE) is a refractory complication of SLE. Read More

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http://dx.doi.org/10.1177/0961203319828818DOI Listing
February 2019
1 Read

Usefulness of composite indices in the assessment of joint involvement in systemic lupus erythematosus patients: correlation with ultrasonographic score.

Lupus 2019 Feb 11:961203319828527. Epub 2019 Feb 11.

Lupus Clinic, Reumatologia, Dipartimento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Viale del Policlinico 155 - 00161 Rome, Italy.

Specific indices are not available to evaluate systemic lupus erythematosus (SLE) joint involvement; indeed, the application of indices validated for rheumatoid arthritis has been suggested. We evaluated the usefulness of organ specific composite indices, i.e. Read More

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http://dx.doi.org/10.1177/0961203319828527DOI Listing
February 2019
1 Read

Effect of pericardial effusion on outcomes in children admitted with systemic lupus erythematosus: a multicenter retrospective cohort study from the United States.

Lupus 2019 Feb 11:961203319828523. Epub 2019 Feb 11.

1 University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock AR, USA.

Objective: We sought to describe characteristics of children admitted with pericardial effusion (PCE) and systemic lupus erythematosus (SLE) and determine the association between PCE and outcomes of interest.

Methods: We performed a retrospective cohort study of the Pediatric Health Information System (PHIS). Patients were included if they were admitted to a PHIS participating hospital from 2004 to 2015 with a diagnosis of SLE and age ≤18 years. Read More

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http://dx.doi.org/10.1177/0961203319828523DOI Listing
February 2019
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Incidence and predictors of aorta calcification in patients with systemic lupus erythematosus.

Lupus 2019 Feb 10:961203319826689. Epub 2019 Feb 10.

1 Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P.R. China.

Objective: Artery calcification, as subclinical atherosclerosis, is attracting attention. The aim of this study was to determine the prevalence and risk factors of artery calcification in patients with systemic lupus erythematosus.

Methods: 641 patients with systemic lupus erythematosus were enrolled in the study. Read More

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http://dx.doi.org/10.1177/0961203319826689DOI Listing
February 2019
1 Read

Peripheral nervous system involvement in systemic lupus erythematosus: a retrospective study on prevalence, associated factors and outcome.

Lupus 2019 Feb 10:961203319828499. Epub 2019 Feb 10.

1 Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S. Anna, Cona (Ferrara), Italy.

Background: Despite its potentially significant impact on disease outcome, peripheral nervous system involvement in systemic lupus erythematosus has received little attention.

Objective: The objective of this study was to assess the prevalence and clinical features of peripheral nervous system involvement in a large cohort of systemic lupus erythematosus patients.

Methods: The records of systemic lupus erythematosus patients examined at two tertiary referral centres over a period of 14 years (from 2000 to 2014) were analyzed. Read More

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http://dx.doi.org/10.1177/0961203319828499DOI Listing
February 2019
1 Read

Pulmonary hypertension in lupus.

Lupus 2019 Feb 10:961203319827653. Epub 2019 Feb 10.

Internal Medicine Department, Hospital Universitario La Paz, Madrid, Spain.

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http://dx.doi.org/10.1177/0961203319827653DOI Listing
February 2019

Levels of anti-Müllerian hormone in premenopausal women with the antiphospholipid syndrome and its association with the risk of clinical complications.

Lupus 2019 Feb 4:961203319828507. Epub 2019 Feb 4.

3 Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

Objective: The study aims to investigate the ovarian reserve in premenopausal women with antiphospholipid syndrome (APS) and to evaluate whether it is associated with cumulative organ damage or the risk of clinical complications.

Methods: This single-center study was conducted in 23 premenopausal female patients (10 with primary APS and 13 with secondary APS) and 24 healthy volunteers. Serum anti-Müllerian hormone (AMH) levels were measured by enzyme-linked immunoassay. Read More

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http://dx.doi.org/10.1177/0961203319828507DOI Listing
February 2019
1 Read

Systemic lupus erythematosus is a risk factor for cancer: a nationwide population-based study in Korea.

Lupus 2019 Feb 2:961203319826672. Epub 2019 Feb 2.

1 Department of Internal Medicine, Chonnam National University Medical School, Gwangju.

Objective: Specific differences in cancer risk have been observed between systemic lupus erythematosus patients and the general population. Although meta-analyses have estimated cancer incidence in systemic lupus erythematosus patients, results have been inconclusive. Hence, we aimed to assess malignancy risk in systemic lupus erythematosus patients, compared to the risk in the general population. Read More

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http://dx.doi.org/10.1177/0961203319826672DOI Listing
February 2019
1 Read

Peripheral neutrophil CD64 index combined with complement, CRP, WBC count and B cells improves the ability of diagnosing bacterial infection in SLE.

Lupus 2019 Feb 2:961203319827646. Epub 2019 Feb 2.

3 Department of Rheumatology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Objective: To investigate the diagnostic role of complement C3, complement C4, C-reactive protein (CRP), procalcitonin (PCT), white blood cell count (WBC), neutrophil CD64 (nCD64) index, lymphocyte subsets and their combination in differentiating bacterial infection from disease relapse in systemic lupus erythematosus (SLE).

Methods: The above biomarkers in 36 hospitalized SLE patients with bacterial infection and 45 with lupus flare without infection were retrospectively studied. Bacterial infection was proven by positive cultures or typical clinical symptoms and signs combined with positive response to antibiotics. Read More

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http://dx.doi.org/10.1177/0961203319827646DOI Listing
February 2019
1 Read

Urinary biomarkers for lupus nephritis: the role of the vascular cell adhesion molecule-1.

Lupus 2019 Feb 2:961203319826695. Epub 2019 Feb 2.

Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predict disease activity and renal histology, but also lead to earlier treatment. Read More

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http://dx.doi.org/10.1177/0961203319826695DOI Listing
February 2019
1 Read

Factors predictive of long-term mortality in lupus nephritis: a multicenter retrospective study of a Japanese cohort.

Lupus 2019 Jan 30:961203319826690. Epub 2019 Jan 30.

1 Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Background: Lupus nephritis (LN) is a major determinant of mortality in systemic lupus erythematosus (SLE). Here we evaluated the association between complete renal response (CR) and mortality in LN.

Methods: We retrospectively analyzed the cases of 172 of 201 patients with LN for whom data on the therapeutic response at 6 and 12 months after induction therapy were available. Read More

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http://dx.doi.org/10.1177/0961203319826690DOI Listing
January 2019
1 Read

Expression of vitamin D receptor in renal tissue of lupus nephritis and its association with renal injury activity.

Lupus 2019 Jan 28:961203319826704. Epub 2019 Jan 28.

Department of Nephrology and Rheumatology, Third Xiangya Hospital, Central South University,Changsha,China.

Objective: Vitamin D receptor (VDR) has potent anti-inflammatory activities. VDR gene polymorphism has been linked with systemic lupus erythematosus (SLE). However, its expression in the kidney has not been evaluated. Read More

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http://dx.doi.org/10.1177/0961203319826704DOI Listing
January 2019
1 Read

'Seronegative antiphospholipid syndrome': an update.

Lupus 2019 Jan 28:961203319826358. Epub 2019 Jan 28.

2 The Lupus Clinic Rheumatology Department, Dubai Hospital, Dubai, United Arab Emirates.

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http://dx.doi.org/10.1177/0961203319826358DOI Listing
January 2019
2 Reads

Early-stage predictors for treatment responses in patients with active lupus nephritis.

Lupus 2019 Jan 25:961203319826703. Epub 2019 Jan 25.

1 Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University; Institute of Nephrology, Zhejiang University; Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, Hangzhou, China.

Objective: We analyzed data of lupus nephritis (LN) patients to find parameters that can predict remission.

Methods: Sixty-four LN patients who were diagnosed with class III, IV, V or V + III/IV by renal biopsy and were followed up for more than six months in our center were enrolled retrospectively. Receiver operating characteristic curves were used to test the predictive values of urinary protein-to-creatinine ratio (UPCR), serum albumin and complement C3 at the first, second and third months as predictors for remission at the sixth month. Read More

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http://dx.doi.org/10.1177/0961203319826703DOI Listing
January 2019
6 Reads

Remission and low disease activity state (LDAS) are protective of intermediate and long-term outcomes in SLE patients. Results from LUMINA (LXXVIII), a multiethnic, multicenter US cohort.

Lupus 2019 Jan 24:961203319826693. Epub 2019 Jan 24.

1 The University of Alabama at Birmingham, Birmingham, USA.

Objective: The objective of this report is to determine the impact of remission and low disease activity state (LDAS) on damage accrual and mortality in systemic lupus erythematosus (SLE) patients.

Patients And Methods: Visits from the Lupus in Minority populations: Nature vs. Nurture (LUMINA) cohort were categorized into remission (Systemic Lupus Activity Measure (SLAM) score = 0 and prednisone ≤ 5 mg/day and no immunosuppressants), LDAS ((not on remission), SLAM score ≤ 3, prednisone ≤ 7. Read More

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http://dx.doi.org/10.1177/0961203319826693DOI Listing
January 2019
2 Reads

Cytomegalovirus infection in Systemic Lupus Erythematosus: report of four cases challenging the management of the disease, and literature review.

Lupus 2019 Jan 24:961203319825570. Epub 2019 Jan 24.

Rheumatology Unit, Azienda Ospedaliera San Camillo - Forlanini, Rome, Italy.

Cytomegalovirus (CMV) is particularly dangerous in systemic lupus erythematosus (SLE), being a problem both for the differential diagnosis with disease flare and for the management of SLE flare with immunosuppressive drugs. We report on four cases of SLE with concomitant CMV infection, having some common clinical and laboratory characteristics. Our data suggest that lupus patients presenting with symptoms such as fever, diarrhea, and respiratory symptoms, alone or in combination, and laboratory evidence of leukopenia, elevated transaminases, and hyponatremia, especially in the setting of recent immunosuppressive treatments, should be screened for CMV. Read More

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http://dx.doi.org/10.1177/0961203319825570DOI Listing
January 2019
1 Read

Utility of neutrophil-to-lymphocyte ratio plus C-reactive protein for infection in systemic lupus erythematosus.

Lupus 2019 Jan 20:961203318821176. Epub 2019 Jan 20.

3 Facultad de Medicina, División de Posgrado, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Objective: To analyze the utility of neutrophil-to-lymphocyte ratio (NLR) plus C-reactive protein (CRP) to differentiate between infection and active disease in patients with SLE.

Methods: A cross-sectional study of a cohort of patients with SLE was carried out. Blood samples from four groups (patients without infection or active disease, patients with infection, patients with active disease, and patients with both infection and active disease) before therapeutic interventions were analyzed. Read More

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http://dx.doi.org/10.1177/0961203318821176DOI Listing
January 2019
2 Reads

Angiotensin II type 2 receptor gene polymorphisms and serum angiotensin-converting enzyme level in Egyptian children with systemic lupus erythematosus.

Lupus 2019 Jan 8:961203318820707. Epub 2019 Jan 8.

4 Pediatric Nephrology Unit, Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Background: There are no reports about the association of angiotensin II type 2 receptor ( AT2R) gene polymorphisms and susceptibility to systemic lupus erythematosus (SLE) in children.

Objective: The objective of this research is to study AT2R gene polymorphisms in exon 3 (C1593A) and intron 1 (A1675G) in Egyptian children with SLE and its correlation with disease manifestations and serum angiotensin-converting enzyme (ACE) level.

Methods: Typing of AT2R gene polymorphisms was conducted in 123 children with SLE in comparison with 100 healthy controls using the restriction fragment length polymorphism method. Read More

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http://dx.doi.org/10.1177/0961203318820707DOI Listing
January 2019

Munchausen by proxy syndrome mimicking childhood-onset systemic lupus erythematosus.

Lupus 2019 Jan 7:961203318821156. Epub 2019 Jan 7.

1 Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Childhood-onset systemic lupus erythematosus (cSLE) is a chronic inflammatory multisystem autoimmune disease that requires multiple differential diagnoses. Munchausen by proxy syndrome (MBPS) is a form of child abuse, where a caregiver intentionally creates a medical history and induces or fabricates signs or disease in a patient. To our knowledge, there is no case report of MBPS mimicking cSLE diagnosis. Read More

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http://dx.doi.org/10.1177/0961203318821156DOI Listing
January 2019
2 Reads

Relationship between endothelial dysfunction, videocapillaroscopy and circulating CD3+CD31+CXCR4+ lymphocytes in systemic lupus erythematosus without cardiovascular risk factors.

Lupus 2019 Jan 4:961203318821161. Epub 2019 Jan 4.

3 Cardiology Unit, ASST-Spedali Civili of Brescia, University of Brescia, Brescia, Italy.

Objective: The objective of this paper is to analyse whether digital capillary morphology, analysed by nailfold videocapillaroscopy (NVC), and the number of circulating CD3 + CD31 + CXCR4 + lymphocytes (angiogenic T cells) could be markers of endothelial dysfunction (ED) in systemic lupus erythematosus (SLE) without cardiovascular disease (CVD) and CV risk factors.

Methods: Nineteen consecutive SLE patients, according to Systemic Lupus International Collaborating Clinics Classification Criteria, with a disease duration less than five years, low disease activity, without CVD and CV risk factors (diabetes, chronic renal disease, uncontrolled systemic arterial hypertension, smoking, hypercholesterolemia, obesity), statin or beta-blocker use were enrolled. Each patient and sex- and age-matched healthy control (HC) underwent Doppler echocardiogram, an endothelial function study by peripheral arterial tonometry technique, NVC and peripheral blood immunophenotyping. Read More

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http://dx.doi.org/10.1177/0961203318821161DOI Listing
January 2019
1 Read

Fatigue in systemic lupus: the role of disease activity and its correlates.

Lupus 2018 Dec 22:961203318817826. Epub 2018 Dec 22.

2 Division of Rheumatology, Rush University Medical Center, Chicago, USA.

Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that leads to a variety of negative health outcomes resulting from inflammation in various organ systems. Although treatment continues to advance, fatigue remains one of the most salient, poorly understood and addressed patient complaints. Understanding the mechanisms of fatigue can help guide the development of interventions to improve health outcomes. Read More

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http://journals.sagepub.com/doi/10.1177/0961203318817826
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http://dx.doi.org/10.1177/0961203318817826DOI Listing
December 2018
12 Reads

Allogeneic adipose-derived stem cells suppress mTORC1 pathway in a murine model of systemic lupus erythematosus.

Lupus 2018 Dec 20:961203318819131. Epub 2018 Dec 20.

1 Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: The aim of our study was to investigate the efficacy of adipose-derived stem cells (ADSC) transplantation in systemic lupus erythematosus (SLE) and to determine the mechanism of ADSC transplantation.

Methods: B6.MRL/lpr mice were administered ADSC intravenously every week from age 28 to 31 weeks, while the lupus control group and the normal control received phosphate buffered solution (PBS) on the same schedule. Read More

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http://dx.doi.org/10.1177/0961203318819131DOI Listing
December 2018
1 Read

Clinical, immunological and microbial gingival profile of juvenile systemic lupus erythematosus patients.

Lupus 2018 Dec 18:961203318819134. Epub 2018 Dec 18.

1 Department of Periodontology, Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Periodontal disease has been associated with rheumatic diseases; however, few studies have evaluated the association with systemic lupus erythematosus (SLE), and its impact on the local inflammatory and microbial profiles. Therefore, this study evaluated the levels of several cytokines in gingival crevicular fluid (GCF) and serum from juvenile SLE (jSLE) patients with gingival inflammation, compared with controls. In addition, we assessed their subgingival microbial profile. Read More

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http://dx.doi.org/10.1177/0961203318819134DOI Listing
December 2018
1 Read

Evaluation of coagulation disorders by thromboelastography in children with systemic lupus erythematosus.

Lupus 2018 Dec 18:961203318819137. Epub 2018 Dec 18.

1 Department of Pediatrics, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China.

Background: The coagulation status of patients with systemic lupus erythematosus (SLE) is quite complicated, and there are currently no simple efficient methods for its evaluation. We explored the feasibility of thromboelastography (TEG) for this purpose.

Methods: Paediatric SLE patients were divided into different groups based on Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores. Read More

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http://dx.doi.org/10.1177/0961203318819137DOI Listing
December 2018
1 Read

Hepatitis A virus vaccination in childhood-onset systemic lupus erythematosus.

Lupus 2018 Dec 14:961203318819827. Epub 2018 Dec 14.

1 Department of Pediatric Rheumatology, Istanbul University, Istanbul, Turkey.

Objectives: Vaccination of systemic lupus erythematosus patients with non-live vaccines may decrease vaccine-preventable infections and mortalities. In the present study, we aimed to compare the immunogenicity and safety of inactivated hepatitis A vaccination in childhood-onset systemic lupus erythematosus and healthy subjects.

Methods: A total of 30 childhood-onset systemic lupus erythematosus and 39 healthy participants who were seronegative for hepatitis A received two doses of the hepatitis A vaccine in a 0- and 6-month schedule. Read More

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http://dx.doi.org/10.1177/0961203318819827DOI Listing
December 2018
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Is systemic lupus erythematosus different in urban versus rural living environment? Data from the Cretan Lupus Epidemiology and Surveillance Registry.

Lupus 2018 Dec 6:961203318816820. Epub 2018 Dec 6.

1 Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Iraklio, Greece.

Background: Examining urban-rural differences can provide insights into susceptibility or modifying factors of complex diseases, yet limited data exist on systemic lupus erythematosus (SLE).

Objective: To study SLE risk, manifestations and severity in relation to urban versus rural residence.

Methodology: Cross-sectional analysis of the Crete Lupus Registry. Read More

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http://dx.doi.org/10.1177/0961203318816820DOI Listing
December 2018

Provider perceptions on the management of lupus during pregnancy: barriers to improved care.

Lupus 2018 Dec 6:961203318815594. Epub 2018 Dec 6.

3 Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA; Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA; Duke-Margolis Center for Health Policy, Duke University, Durham, North Carolina, USA.

Background: More than half of pregnancies in women with systemic lupus erythematosus (lupus) result in adverse outcomes for the mother or the fetus. We sought to identify aspects of current rheumatologic care that could be improved to decrease the frequency of poor outcomes.

Methods: Focus groups with clinical rheumatologists, based on the PRECEDE/PROCEED framework, identified factors that influenced care. Read More

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http://dx.doi.org/10.1177/0961203318815594DOI Listing
December 2018
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Alcohol intake and risk of systemic lupus erythematosus: a Mendelian randomization study.

Authors:
S C Bae Y H Lee

Lupus 2018 Dec 12:961203318817832. Epub 2018 Dec 12.

2 Department of Rheumatology, Korea University College of Medicine, Seoul, Korea.

Objectives: This study aimed to examine whether alcohol intake is causally associated with systemic lupus erythematosus (SLE).

Methods: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and an SLE GWAS consisting of 1311 SLE and 1783 control subjects of European descent as the outcome. Read More

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http://dx.doi.org/10.1177/0961203318817832DOI Listing
December 2018
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Chylous ascites and podocytopathy as the presentation of childhood lupus-an unusual occurrence.

Lupus 2018 Dec 8:961203318817831. Epub 2018 Dec 8.

1 Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Systemic lupus erythematosus (SLE) is an autoimmune disorder that can affect virtually any organ. Chylous ascites as a presenting manifestation of SLE has been described in a handful of cases in adults. However, to the best of our knowledge this presentation has never been reported in the pediatric age group. Read More

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http://dx.doi.org/10.1177/0961203318817831DOI Listing
December 2018
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Invasive fungal disease in patients with systemic lupus erythematosus from Southern China: a retrospective study.

Lupus 2019 Jan 8;28(1):77-85. Epub 2018 Dec 8.

1 Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objective: To investigate the characteristics and associated factors of invasive fungal disease in patients with systemic lupus erythematosus from Southern China.

Methods: A retrospective study was performed. Demographic and clinical characteristics, laboratory data, and radiographic manifestations were recorded. Read More

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http://dx.doi.org/10.1177/0961203318817118DOI Listing
January 2019
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Disease course patterns in systemic lupus erythematosus.

Lupus 2018 Dec 8:961203318817132. Epub 2018 Dec 8.

Centre for Prognosis Studies in Rheumatic Diseases, Toronto Lupus Clinic, Toronto, Canada.

Background: Disease activity in systemic lupus erythematosus follows three different courses: long quiescent, relapsing remitting and persistently active. However, the patterns of disease course since diagnosis are not known. This study aimed to assess the prevalence and characteristics of such patterns over 10 years. Read More

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http://dx.doi.org/10.1177/0961203318817132DOI Listing
December 2018
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Are serum autoantibodies associated with brain changes in systemic lupus erythematosus? MRI data from the Leiden NP-SLE cohort.

Lupus 2018 Dec 8:961203318816819. Epub 2018 Dec 8.

1 Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.

Objective: The effect of serum autoantibodies on the brain of systemic lupus erythematosus (SLE) patients remains unclear. We investigated whether serum autoantibodies, individually and assessed in groups, are associated with specific brain-MRI abnormalities or whether these structural changes are associated with other SLE-related or traditional cardiovascular disease risk factors.

Methods: All patients underwent brain 3Tesla-MRI. Read More

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http://dx.doi.org/10.1177/0961203318816819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304692PMC
December 2018
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The Perceived Stress Scale-10 (PSS-10) is reliable and has construct validity in Chinese patients with systemic lupus erythematosus.

Lupus 2018 Dec 5:961203318815595. Epub 2018 Dec 5.

1 School of Nursing, Tianjin Medical University, Tianjin City, People's Republic of China.

Systemic lupus erythematosus is a chronic, progressive, autoimmune disease that causes significant stress on patients. There is no specific instrument for assessing stress in Chinese systemic lupus erythematosus patients. The objective of this study was to test the reliability and validity of the 10-item Perceived Stress Scale in Chinese systemic lupus erythematosus patients. Read More

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http://dx.doi.org/10.1177/0961203318815595DOI Listing
December 2018
15 Reads

Sexual dimorphism in SLE: above and beyond sex hormones.

Lupus 2018 Dec 1:961203318815768. Epub 2018 Dec 1.

1 Laboratory of Inflammation and Autoimmunity, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Systemic lupus erythematosus (SLE) is characterized by aberrant production of auto-antibodies and a sexual dimorphism both in the phenotypic expression and frequency of the disease between males and females. The striking female predominance was initially attributed primarily to sex hormones. However, recent data challenge this simplistic view and point more towards genetic and epigenetic factors accounting for this difference. Read More

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http://dx.doi.org/10.1177/0961203318815768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304686PMC
December 2018

Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients.

Lupus 2018 Dec 3:961203318815764. Epub 2018 Dec 3.

1 Discipline of Urology, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil.

Objective: To evaluate sperm DNA fragmentation analysis in non-azoospermic male systemic lupus erythematosus (SLE) patients.

Methods: Twenty-eight consecutive male SLE patients (American College of Rheumatology criteria) and 34 healthy controls were evaluated for demographic/exposures data, urological evaluation, hormone profile and sperm analysis (including sperm DNA fragmentation). Clinical features, disease activity/damage scores and treatment were also evaluated. Read More

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http://dx.doi.org/10.1177/0961203318815764DOI Listing
December 2018
2 Reads