884,405 results match your criteria Lungs


Rapid Drug Desensitization with Chemotherapeutics (Platins, Taxanes, and Others): A Single-Center Retrospective Study.

Int Arch Allergy Immunol 2019 Mar 20:1-9. Epub 2019 Mar 20.

Background: Rapid drug desensitization (RDD) induces a temporary tolerance to chemotherapeutics that induce hypersensitivity reactions (HSRs).

Purpose: Our objective is to report our experience with RDD to platins, taxanes, etoposide, doxorubicin, and irinotecan.

Methods: The study was conducted as a retrospective chart review of patients with symptoms of HSRs to chemotherapeutics. Read More

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http://dx.doi.org/10.1159/000496745DOI Listing

The dependence of interplay effects on the field scan direction in PBS proton therapy.

Phys Med Biol 2019 Mar 20. Epub 2019 Mar 20.

Center for Proton Therapy, Paul Scherrer Institute, WMSA/C12, Villigen - PSI, 5232, SWITZERLAND.

The literature is controversial about the scan direction dependency of interplay effects in pencil beam scanning (PBS) treatment of moving targets. A directional effect is supported by many simulation studies, whereas the experimental data are mostly limited to simple geometries, not reflecting realistically clinical treatment plans. We have compared increasingly complex treatment fields, from a homogeneous single energy layer to a more modulated lung plan, under identical experimental settings, seeking evidence for differences in motion mitigation due to the selection of primary scanning direction. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1150DOI Listing

Thyroxine promotes lung cancer growth in an orthotopic mouse model.

Endocr Relat Cancer 2019 Mar 1. Epub 2019 Mar 1.

L Moeller, Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Thyroid hormones are important for physiology and homeostasis. In addition to nuclear thyroid hormone receptors, the plasma membrane protein integrin αvβ3 has been recognized as a receptor for both thyroxine (T4) and triiodothyronine (T3). Here, we studied whether thyroid hormone promotes growth of murine lung cancer via αvβ3 in vivo. Read More

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http://dx.doi.org/10.1530/ERC-18-0353DOI Listing

Comparison of indoor air quality during sleep in smokers and non-smokers' bedrooms: A preliminary study.

Environ Pollut 2019 Mar 11;249:248-256. Epub 2019 Mar 11.

Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, Km 139.7, 2695-066, Bobadela, LRS, Portugal.

People spend one third of their life sleeping, but the bedroom, as a specific micro-environment, is often neglected when assessing human exposure to air pollutants. However, exposure during sleep may be significant in the long-term to the integrated individual exposure. This study aimed to assess the exposure during sleep, focusing on a multi-pollutant approach (comfort parameters, carbon dioxide - CO, carbon monoxide - CO, formaldehyde (CHO), total volatile organic compounds (VOCs), particulate matter - PM and PM - and ultrafine particles, particle number concentrations - PNC - and lung deposited surface area - LDSA). Read More

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http://dx.doi.org/10.1016/j.envpol.2019.03.021DOI Listing

In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors.

Cell Rep 2019 Mar;26(12):3231-3245.e9

Cardiovascular & Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore, Singapore 169857, Singapore; Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden. Electronic address:

Regeneration of injured human heart muscle is limited and an unmet clinical need. There are no methods for the reproducible generation of clinical-quality stem cell-derived cardiovascular progenitors (CVPs). We identified laminin-221 (LN-221) as the most likely expressed cardiac laminin. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.02.083DOI Listing

Osteopontin plays important roles in pulmonary arterial hypertension induced by systemic-to-pulmonary shunt.

FASEB J 2019 Mar 20:fj201802121RR. Epub 2019 Mar 20.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease-Chinese Academy of Medical Sciences Peking Union Medical College, Beijing, China.

Recent studies indicated that osteopontin (OPN) was involved in the genesis and progression of pulmonary arterial hypertension (PAH); however, its role in congenital heart disease-associated PAH (CHD/PAH) remains unknown. Our results showed that OPN was increased in lungs and plasma of patients with Eisenmenger syndrome; moreover, OPN and αβ-integrin expression levels were augmented in rat lungs exposed to systemic-to-pulmonary shunt. Cell culture assay demonstrated that distal pulmonary arterial smooth muscle cells (PASMCs) from rat lungs suffering from volume and pressure overload exhibited enhanced proliferation compared with those from healthy rats. Read More

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http://dx.doi.org/10.1096/fj.201802121RRDOI Listing

Residential Exposure to Outdoor Air Pollution and Post-Bronchodilator Lung Function Deficits in Mid-Adult Life.

Am J Respir Crit Care Med 2019 Mar 20. Epub 2019 Mar 20.

The University of Melbourne, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1164/rccm.201811-2139LEDOI Listing

[Hemorrhagic fever with renal syndrome group outbreak caused by Sochi virus.]

Vopr Virusol 2019 ;64(1):36-41

Chumakov federal scientific center for research and development of immune-and-biological products of Russian academy of sciences, 108819, Moscow, Russian Federation.

Background: Hemorrhagic fever with renal syndrome (HFRS) occupies a leading place among natural focal human diseases in the Russian Federation. Sporadic incidence of HFRS-Sochi has been annually recorded in the Krasnodar Territory since 2000. The group outbreak of the HFRS-Sochi was first registered in Gelendzhik in the fall of 2013. Read More

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http://dx.doi.org/10.18821/0507-4088-2019-64-1-36-41DOI Listing
January 2019

Baroreflex control of sympathetic vasomotor activity and resting arterial pressure at high altitude: insight from Lowlanders and Sherpa.

J Physiol 2019 Mar 20. Epub 2019 Mar 20.

Extremes Research Group, School of Sport, Health and Exercise Sciences, Bangor University, Wales, UK.

Key Points Summary: Hypoxia, a potent activator of the sympathetic nervous system, is known to increase muscle sympathetic nerve activity (MSNA) to the peripheral vasculature of native Lowlanders during sustained high altitude (HA) exposure. We show that the arterial baroreflex control of MSNA functions normally in healthy Lowlanders at HA, and that upward baroreflex resetting permits chronic activation of basal sympathetic vasomotor activity under this condition. The baroreflex MSNA operating point and resting sympathetic vasomotor outflow both are lower for highland Sherpa compared with acclimatizing Lowlanders; these lower levels may represent beneficial hypoxic adaptation in Sherpa. Read More

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http://dx.doi.org/10.1113/JP277663DOI Listing

Optical Coherence Tomography Angiography Highlights Chorioretinal Lesions in Ocular Coccidioidomycosis.

Ophthalmic Surg Lasers Imaging Retina 2019 Mar;50(3):e71-e73

A 34-year-old woman presented after recovering from a disseminated Coccidioides immitis infection of the lungs, blood, brain, and placenta. The patient was asymptomatic for visual complaints. Visual acuity was 20/20 in both eyes. Read More

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http://dx.doi.org/10.3928/23258160-20190301-14DOI Listing

Comparative histopathologic and viral immunohistochemical studies on CeMV infection among Western Mediterranean, Northeast-Central, and Southwestern Atlantic cetaceans.

PLoS One 2019 20;14(3):e0213363. Epub 2019 Mar 20.

Laboratory of Wildlife Comparative Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil.

Cetacean morbillivirus (CeMV) is a major natural cause of morbidity and mortality in cetaceans worldwide and results in epidemic and endemic fatalities. The pathogenesis of CeMV has not been fully elucidated, and questions remain regarding tissue tropism and the mechanisms of immunosuppression. We compared the histopathologic and viral immunohistochemical features in molecularly confirmed CeMV-infected Guiana dolphins (Sotalia guianensis) from the Southwestern Atlantic (Brazil) and striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from the Northeast-Central Atlantic (Canary Islands, Spain) and the Western Mediterranean Sea (Italy). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213363PLOS

High amplitude bubble continuous positive airway pressure decreases lung injury in rats with ventilator-induced lung injury.

J Chin Med Assoc 2019 Mar 11. Epub 2019 Mar 11.

Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.

Background: Bubble continuous positive airway pressure (BCPAP) has been used in neonates with respiratory distress for decades; however, the optimal setting for BCPAP circuits remains unknown. This study compared the gas exchange efficiency and lung protection efficacy between conventional and high-amplitude BCPAP devices.

Methods: We compared gas exchange, lung volume, and pulmonary inflammation severity among rats with ventilator-induced lung injury (VILI) who were treated with conventional BCPAP (BCPAP with an expiratory limb at 0°), high-amplitude BCPAP (BCPAP with an expiratory limb at 135°), or spontaneous breathing (SB). Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000070DOI Listing

Effects of intratracheal captopril on severely meconium-injured piglet lungs.

J Chin Med Assoc 2019 Mar 11. Epub 2019 Mar 11.

Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.

Background: Severe meconium aspiration syndrome (MAS) may cause intractable respiratory failure in neonates. Targeting the renin-angiotensin system may be an effective way to treat such pulmonary dysfunction. Captopril has the potential to mitigate the severity of lung injury by inhibiting angiotensin-converting enzyme. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000044DOI Listing

Long-term ventilation for children with chronic lung disease of infancy.

Curr Opin Pediatr 2019 Mar 18. Epub 2019 Mar 18.

Section of Pulmonary Medicine and Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado, School of Medicine, Aurora, Colorado, USA.

Purpose Of Review: Modern medical advances have resulted in an increased survival after extremely preterm birth. However, some infants will develop severe bronchopulmonary dysplasia (BPD) and fail to wean from invasive or noninvasive positive pressure support. It remains unclear which infants will benefit from tracheostomy placement for chronic ventilation. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000757DOI Listing

Advance care planning for patients and their relatives.

Int J Palliat Nurs 2019 Mar;25(3):112-127

Centre for Health Sciences Education, Aarhus University, Denmark.

Background:: Advance care planning (ACP) has been suggested to improve the quality of life (QoL) and mental wellbeing in severely ill patients and their relatives.

Aim:: To investigate the effects of ACP among patients with lung, heart and cancer diseases with an estimated life-span of up to 12 months.

Methods:: Patients and relatives were randomised into two groups: one receiving usual care and one receiving ACP and usual care. Read More

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http://www.magonlinelibrary.com/doi/10.12968/ijpn.2019.25.3.
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http://dx.doi.org/10.12968/ijpn.2019.25.3.112DOI Listing
March 2019
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ALK Resistance Mutations and Efficacy of Lorlatinib in Advanced Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer.

J Clin Oncol 2019 Mar 20:JCO1802236. Epub 2019 Mar 20.

10 Pfizer Oncology, La Jolla, CA.

Purpose: Lorlatinib is a potent, brain-penetrant, third-generation anaplastic lymphoma kinase (ALK)/ROS1 tyrosine kinase inhibitor (TKI) with robust clinical activity in advanced ALK-positive non-small-cell lung cancer, including in patients who have failed prior ALK TKIs. Molecular determinants of response to lorlatinib have not been established, but preclinical data suggest that ALK resistance mutations may represent a biomarker of response in previously treated patients.

Patients And Methods: Baseline plasma and tumor tissue samples were collected from 198 patients with ALK-positive non-small-cell lung cancer from the registrational phase II study of lorlatinib. Read More

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http://dx.doi.org/10.1200/JCO.18.02236DOI Listing

Low guanylyl cyclase activity in Weddell seals: Implications for peripheral vasoconstriction and perfusion of the brain during diving.

Am J Physiol Regul Integr Comp Physiol 2019 Mar 20. Epub 2019 Mar 20.

Anesthesia, Critical Care & Pain Medicine, Massachusetts General Hospital.

Nitric oxide (NO) is a potent vasodilator, which improves perfusion and oxygen delivery during tissue hypoxia in terrestrial animals. The vertebrate dive response involves vasoconstriction in select tissues, which persists despite profound hypoxia. Using tissues collected from Weddell seals at necropsy, we investigated whether vasoconstriction is aided by down-regulation of local hypoxia signaling mechanisms. Read More

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http://dx.doi.org/10.1152/ajpregu.00283.2018DOI Listing

Successful ceftazidime-avibactam treatment of post-surgery Burkholderia multivorans genomovar II bacteremia and brain abscesses in a young lung transplanted woman with cystic fibrosis.

Transpl Infect Dis 2019 Mar 20:e13082. Epub 2019 Mar 20.

Cystic Fibrosis Center, IRCCS Ca' Granda Foundation Milan, Italy.

Burkholderia cepacia complex (Bcc) includes several phenotypically similar but genotypically distinct gram-negative bacteria (GNB) that can colonize the respiratory tract of Cystic Fibrosis (CF) patients. Pathogens are difficult to treat due to intrinsic resistance to multiple antibiotics and are associated to a more rapid decline in lung function and to increased mortality, particularly after lung transplantation. For all these reasons chronic infection by Burkholderia (B) cenocepacia is presently considered a relative or absolute contraindication in almost all lung transplant centres. Read More

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http://dx.doi.org/10.1111/tid.13082DOI Listing

Low-income homebound older adults receiving home-delivered meals: Physical and mental health conditions, incidence of falls and hospitalisations.

Health Soc Care Community 2019 Mar 20. Epub 2019 Mar 20.

University of Texas at Austin Steve Hicks School of Social Work, Austin, Texas.

Significant differences in health across racial/ethnic and socioeconomic groups in the US signal increasing numbers of low-income homebound older adults in a rapidly ageing society. The purpose of this study was to examine physical and psychiatric conditions and their association with incidence of self-reported falls and hospitalisations among largely low-income and racial/ethnic minority adults age 50+ (N = 2,224), clients from a home-delivered meals programme in Central Texas. Data came from comprehensive, in-home assessments done in 2017 by these older adults' case managers. Read More

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http://dx.doi.org/10.1111/hsc.12741DOI Listing

Reduced or Absent "Lung Sliding" - A Novel Lung Ultrasound Sign of Pediatric Foreign Body Aspiration.

J Ultrasound Med 2019 Mar 20. Epub 2019 Mar 20.

Pathology Department, Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases, Sremska Kamenica, Serbia.

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http://dx.doi.org/10.1002/jum.14988DOI Listing

Circulating mast cell progenitors correlate with reduced lung function in allergic asthma.

Clin Exp Allergy 2019 Mar 20. Epub 2019 Mar 20.

Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

Background: Studies using mouse models have revealed that mast cell progenitors are recruited from the blood circulation to the lung during acute allergic airway inflammation. The discovery of a corresponding human mast cell progenitor population in the blood has enabled to study the relation of circulating mast cell progenitors in clinical settings.

Objectives: To explore the possible association between the frequency of mast cell progenitors in the blood circulation and allergic asthma, we assessed the relation of this recently identified cell population with asthma outcomes and inflammatory mediators in allergic asthmatics and controls. Read More

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http://dx.doi.org/10.1111/cea.13388DOI Listing

Influence of Multimorbidity on Burden and Appropriateness of Implantable Cardioverter-Defibrillator Therapies.

J Am Geriatr Soc 2019 Mar 20. Epub 2019 Mar 20.

Division of Research, Kaiser Permanente Northern California, Oakland, California.

Objective: To determine whether burden of multiple chronic conditions (MCCs) influences the risk of receiving inappropriate vs appropriate device therapies.

Design: Retrospective cohort study.

Setting: Seven US healthcare delivery systems. Read More

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http://dx.doi.org/10.1111/jgs.15839DOI Listing

Lightning-strike-induced acute lung injury: a case report.

Ulus Travma Acil Cerrahi Derg 2019 Mar;25(2):198-201

Department of Emergency Medicine, Ankara Atatürk Training and Research Hospital, Ankara-Turkey.

Lightning strike is an environmental electrical injury with high rates of morbidity and mortality. Lightning strike injuries are also considered to be high-voltage injuries. Respiratory injuries associated with lightning strikes include pulmonary edema, pulmonary contusion, acute respiratory distress syndrome, and pulmonary hemorrhage. Read More

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http://dx.doi.org/10.5505/tjtes.2018.41861DOI Listing

Effects of replacing sitting time with physical activity on lung function: An analysis of the Canadian Longitudinal Study on Aging.

Health Rep 2019 Mar;30(3):12-23

College of Health Solutions, Arizona State University, Phoenix, Arizona, United States.

Background: Sitting time and physical activity may be modifiable determinants of lung function. The purpose of this study was to assess the effect that replacing various movement behaviours has on lung function among individuals with and without obstructive lung disease.

Data And Methods: For analysis, data were used from participants of the Canadian Longitudinal Study on Aging, recruited between 2012 and 2015. Read More

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http://dx.doi.org/10.25318/82-003-x201900300002-engDOI Listing
March 2019
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Pituitary Metastases: a Nationwide Study on Current Characteristics with Special Reference to Breast Cancer.

J Clin Endocrinol Metab 2019 Mar 20. Epub 2019 Mar 20.

Department of Endocrinology, Skåne University Hospital, Lund University, Malmö, Sweden.

Objective: To investigate the contemporary presentation of pituitary metastases.

Patients: Thirty-eight patients diagnosed with pituitary metastases 1996 to 2018 in Sweden.

Methods: Pituitary metastases were confirmed by histopathology (n = 27) or considered highly likely due to radiological findings, including rapid tumor progression (n = 11). Read More

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http://dx.doi.org/10.1210/jc.2019-00012DOI Listing

Is low serum albumin associated with postoperative bronchopleural fistula in patients undergoing pulmonary resections?

Interact Cardiovasc Thorac Surg 2019 Mar 19. Epub 2019 Mar 19.

Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether low serum albumin (sAlb) was associated with postoperative bronchopleural fistula (BPF) in patients undergoing pulmonary resections. Altogether 660 papers were found using the reported search, of which 5 retrospective cohort studies represented the best evidence to answer the clinical question. Read More

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http://dx.doi.org/10.1093/icvts/ivz084DOI Listing

Exposure of Toxocara canis eggs to Purpureocillium lilacinum as a biocontrol strategy: an experimental model evaluation.

Rev Bras Parasitol Vet 2019 Mar 11. Epub 2019 Mar 11.

Programa de Pós-graduação em Parasitologia, Departamento de Microbiologia e Parasitologia, Instituto de Biologia, Universidade Federal de Pelotas - UFPel, Pelotas, RS, Brasil.

Purpureocillium lilacinum is a nematophagous fungus used in biological control against some parasites, including Toxocara canis. This study researched the infectivity of embryonated T. canis eggs after exposure to the fungus P. Read More

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http://dx.doi.org/10.1590/S1984-29612019007DOI Listing

New determinants for casual peripheral mechanism of neurogenic lung edema in subarachnoid hemorrhage due to ischemic degeneration of vagal nerve, kidney and lung circuitry. Experimental study1.

Acta Cir Bras 2019 Mar 18;34(3):e201900303. Epub 2019 Mar 18.

MD, Department of Pathology, Medical Faculty, Ataturk University, Erzurum, Turkey. Histopathological examinations.

Purpose: To evaluate whether there is a relationship between renal artery vasospasm related low glomerular density or degeneration and neurogenic lung edema (NLE) following subarachnoid hemorrhage.

Methods: This study was conducted on 26 rabbits. A control group was formed of five animals, a SHAM group of 5 to which saline and a study group (n=16) injected with homologous blood into the sylvian cisterna. Read More

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http://dx.doi.org/10.1590/s0102-865020190030000003DOI Listing

Gene expression classification of lung adenocarcinoma into molecular subtypes.

IEEE/ACM Trans Comput Biol Bioinform 2019 Mar 18. Epub 2019 Mar 18.

As one of the most common malignancies in the world, lung adenocarcinoma (LUAD) is currently difficult to cure. However, the advent of precision medicine provides an opportunity to improve the treatment of lung cancer. Subtyping lung cancer plays an important role in performing a specific treatment. Read More

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http://dx.doi.org/10.1109/TCBB.2019.2905553DOI Listing

B-spline based sharp feature preserving shape reconstruction approach for electrical impedance tomography.

IEEE Trans Med Imaging 2019 Mar 18. Epub 2019 Mar 18.

This paper presents a B-spline based shape reconstruction approach for electrical impedance tomography (EIT). In the proposed approach, the conductivity distribution to be reconstructed is assumed to be piecewise constant. The geometry of the inclusions is parameterized using B-spline curves, and the EIT forward solver is modified as a set of control points representing the inclusions' boundary to the data on the domain boundary. Read More

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http://dx.doi.org/10.1109/TMI.2019.2905245DOI Listing

Mitigation of radiation-induced pneumonitis and lung fibrosis using alpha-lipoic acid and resveratrol.

Antiinflamm Antiallergy Agents Med Chem 2019 Mar 19. Epub 2019 Mar 19.

Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah. Iran.

Background: Lung is a late response and radiosensitive organ. Studies have shown that exposure of the lung to acute and high doses of radiation following inhalation of radioactive agents or an accidental radiological event may lead to pneumonitis and fibrosis, which are associated with a risk of death. So far, some agents have been studied for mitigation of pneumonitis and fibrosis following exposure of murine lung tissues to ionizing radiation. Read More

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http://dx.doi.org/10.2174/1871523018666190319144020DOI Listing

The Transcription Factor ERG Regulates Super-Enhancers Associated with an Endothelial-Specific Gene Expression Program.

Circ Res 2019 Mar 20. Epub 2019 Mar 20.

National Heart and Lung Institute, Vascular Sciences, Imperial College London.

Rationale: The ETS transcription factor (TF) ERG is essential for endothelial homeostasis, driving expression of lineage genes and repressing pro-inflammatory genes. Loss of ERG expression is associated with diseases including atherosclerosis. ERG's homeostatic function is lineage-specific, since aberrant ERG expression in cancer is oncogenic. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313788DOI Listing

Combining the best of two worlds: Highly flexible chimeric antigen receptor adaptor molecules (CAR-adaptors) for the recruitment of chimeric antigen receptor T cells.

MAbs 2019 Mar 20. Epub 2019 Mar 20.

a Roche Pharmaceutical Research & Early Development, Roche Innovation Center , Zurich, Wagistrasse 10, 8952 Schlieren , Switzerland.

Chimeric antigen receptor (CAR)-engineered T cells have a proven efficacy for the treatment of refractory hematological B cell malignancies. While often accompanied by side effects, CAR-T technology is getting more mature and will become an important treatment option for various tumor indications. In this review, we summarize emerging approaches that aim to further evolve CAR-T cell therapy based on combinations of so-called universal or modular CAR-(modCAR-)T cells, and their respective adaptor molecules (CAR-adaptors), which mediate the crosslinking between target and effector cells. Read More

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http://dx.doi.org/10.1080/19420862.2019.1596511DOI Listing

Is long-term survival possible for patients with stage IV ALK+ non-small cell lung cancer?

Expert Rev Respir Med 2019 Mar 20:1-3. Epub 2019 Mar 20.

a Department of Internal Medicine, Division of Medical Oncology , University of Colorado Cancer Center , Aurora , CO , USA.

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http://dx.doi.org/10.1080/17476348.2019.1596028DOI Listing

MLN4924 protects against interleukin-17A-induced pulmonary inflammation by disrupting ACT1-mediated signaling.

Am J Physiol Lung Cell Mol Physiol 2019 Mar 20. Epub 2019 Mar 20.

Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, China.

An excessive inflammatory response in terminal airways, alveoli, and the lung interstitium eventually leads to pulmonary hypertension and chronic obstructive pulmonary disease. Proinflammatory cytokine interleukin-17A (IL-17A) has been implicated in the pathogenesis of pulmonary inflammatory diseases. MLN4924, an inhibitor of NEDD8-activating enzyme (NAE), is associated with the treatment of various types of cancers, but its role in the IL-17A-mediated inflammatory response has not been identified. Read More

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http://dx.doi.org/10.1152/ajplung.00349.2018DOI Listing

Acetyl-CoA carboxylase inhibition regulates microtubule dynamics and intracellular transport in cystic fibrosis epithelial cells.

Am J Physiol Lung Cell Mol Physiol 2019 Mar 20. Epub 2019 Mar 20.

Pediatrics, Case Western Reserve University, United States.

The use of high-dose ibuprofen as an anti-inflammatory therapy in cystic fibrosis has been shown to be an effective intervention though use is limited due to potential adverse events. Identifying the mechanism of ibuprofen efficacy would aid in the development of new therapies that avoid these adverse events. Previous findings demonstrated that ibuprofen treatment restores the regulation of microtubule dynamics in cystic fibrosis (CF) epithelial cells through a 5' adenosine monophosphate-activated protein kinase (AMPK)-dependent mechanism. Read More

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http://dx.doi.org/10.1152/ajplung.00369.2018DOI Listing

Activation of mTORC1/PGC1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium.

Am J Physiol Lung Cell Mol Physiol 2019 Mar 20. Epub 2019 Mar 20.

Center of Translational Medicine, Thomas Jefferson University, United States.

Cellular senescence is a biological process by which cells lose their capacity to proliferate yet remain metabolically active. Although originally considered a protective mechanism to limit the formation of cancer, it is now appreciated that cellular senescence also contributes to the development of disease, including common respiratory ailments, such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. While many factors have been linked to the development of cellular senescence, mitochondrial dysfunction has emerged as an important causative factor. Read More

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http://dx.doi.org/10.1152/ajplung.00244.2018DOI Listing

Senescence in the Lung: Is This Getting Old?

Am J Physiol Lung Cell Mol Physiol 2019 Mar 20. Epub 2019 Mar 20.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, United States.

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http://dx.doi.org/10.1152/ajplung.00081.2019DOI Listing

Vascular TSP1-CD47 Signaling Promotes Sickle Cell-Associated Arterial Vasculopathy and Pulmonary Hypertension in Mice.

Am J Physiol Lung Cell Mol Physiol 2019 Mar 20. Epub 2019 Mar 20.

Medicine, Vascular Medicine Institute, University of Pittsburgh, United States.

Pulmonary hypertension (PH) is a leading cause of death in sickle cell disease (SCD). Hemolysis and oxidative stress are contributing factors to SCD-associated PH. We have reported that the protein thrombospondin-1 (TSP1) is elevated in the plasma of patients with SCD and by interacting with its receptor CD47 limits vasodilation of distal pulmonary arteries ex vivo. Read More

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http://dx.doi.org/10.1152/ajplung.00302.2018DOI Listing

Prophylactic treatment with MSC derived exosomes attenuates traumatic acute lung injury in rats.

Am J Physiol Lung Cell Mol Physiol 2019 Mar 20. Epub 2019 Mar 20.

Department of Anesthesiology, China-Japan Union Hospital of Jilin University, China.

Mesenchymal stem cell (MSC) is a potential strategy in the pretreatment of traumatic acute lung injury (ALI), a disease which causes inflammation and oxidative stress (OS). This study aimed to investigate whether MSCs-exosomal microRNA-124-3p (miR-124-3p) affects traumatic ALI. Initially, a traumatic ALI rat model was established using the weight-drop method. Read More

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http://dx.doi.org/10.1152/ajplung.00391.2018DOI Listing

Extracellular Vesicles in Lung Health, Disease, and Therapy: Mini-Review and Special Call for papers.

Am J Physiol Lung Cell Mol Physiol 2019 Mar 20. Epub 2019 Mar 20.

Institute of Physiology, Charité - Universitaetsmedizin Berlin, Germany.

Both physiological homeostasis and pathological disease processes in the lung typically result from complex, yet coordinated multicellular responses which are synchronized via paracrine and endocrine intercellular communication pathways. Of late, extracellular vesicles have emerged as important information shuttles that can coordinate and disseminate homeostatic and disease signals. In parallel, extracellular vesicles in biological fluids such as sputum, mucus, epithelial lining fluid, edema fluid, the pulmonary circulation, pleural fluid, and lymphatics have emerged as promising candidate biomarkers for diagnosis and prognosis in lung disease. Read More

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http://dx.doi.org/10.1152/ajplung.00546.2018DOI Listing

Lung growth after pneumonectomy: searching for the right stimuli.

Authors:
Matthias Ochs

Am J Physiol Lung Cell Mol Physiol 2019 Mar 20. Epub 2019 Mar 20.

Institute of Anatomy, Charité - Universitaetsmedizin Berlin, Germany.

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http://dx.doi.org/10.1152/ajplung.00119.2019DOI Listing

Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.

Am J Physiol Lung Cell Mol Physiol 2019 Mar 20. Epub 2019 Mar 20.

Pulmonary and Critical Care Division, Northwestern University, United States.

Cardiac glycosides (CG) are used primarily for cardiac failure and have been reported to have other effects, including inhibition of viral replication. Here we set out to study mechanisms by which CG as inhibitors of the Na,K-ATPase, decrease influenza A virus (IAV) replication in the lungs. We found that CG inhibit influenza virus replication in alveolar epithelial cells by decreasing intracellular potassium which in turn inhibits protein translation, independently of viral entry, mRNA transcription, and protein degradation. Read More

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http://dx.doi.org/10.1152/ajplung.00173.2018DOI Listing

Using Novel CT Analysis to Describe the Contribution and Distribution of Emphysema and Small Airways Disease in COPD.

Ann Am Thorac Soc 2019 Mar 20. Epub 2019 Mar 20.

University of Southampton, Faculty of medicine, Clinical and Experimental Sciences, Southampton, United Kingdom of Great Britain and Northern Ireland.

Rationale: Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation, caused by emphysema and small airways disease (SAD). CT, coupled with image analysis enables the quantification of these abnormalities, however the optimum method for doing so has not been determined.

Objectives: This study aims to compare two quantitative analysis techniques, disease probability measure (DPM), and parametric response mapping (PRM) and assess their relationship with specific physiological measures of SAD. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201810-669OCDOI Listing

Idiopathic Pulmonary Fibrosis and Lung Cancer: A Systematic Review and Meta-Analysis.

Ann Am Thorac Soc 2019 Mar 20. Epub 2019 Mar 20.

Icahn School of Medicine at Mount Sinai Tisch Cancer Institute, 145753, New York, New York, United States.

Rationale: The association between idiopathic pulmonary fibrosis (IPF) and lung cancer has been previously reported. However, there is the potential for significant confounding by age and smoking, and an accurate summary risk estimate has not been previously ascertained.

Objectives: The aim was to determine the risk and burden of lung cancer in patients with IPF, accounting for known confounders. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201807-481OCDOI Listing

Serum Metabolomics Study of Non-Smoking Female Patients with Non-Small Cell Lung Cancer Using a Gas Chromatography-Mass Spectrometry.

J Proteome Res 2019 Mar 20. Epub 2019 Mar 20.

The incidence of non-smoking female patients with non-small cell lung cancer (NSCLC) is increasing in recent decades. However, the pathogenesis of patients is unclear and early diagnosis biomarkers are in urgent need. In this study, 136 non-smoking female subjects (65 patients with NSCLC, 6 patients with benign lung tumors and 65 healthy controls) were enrolled, and their metabolic profiling was investigated by using a pseudotargeted gas chromatography-mass spectrometry. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00069DOI Listing

Anti-inflammatory Property of Imperatorin on Alveolar Macrophages and Inflammatory Lung Injury.

J Nat Prod 2019 Mar 20. Epub 2019 Mar 20.

Institute of New Drug Development , China Medical University , No. 91 Hsueh-Shih Road , Taichung , 40402 , Taiwan.

Imperatorin is one of the furanocoumarin derivatives and exists in many medicinal herbs with anticancer, antiviral, antibacterial, and antihypertensive activities. In this study, we examined the anti-inflammatory effects of imperatorin on inflammation-associated lung diseases. Imperatorin reduced iNOS and COX-2 expression and also IL-6 and TNFα production enhanced by zymosan. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.9b00145DOI Listing

Bio-Inspired NanoVilli Chips for Enhanced Capture of Tumor-Derived Extracellular Vesicles: Toward Non-Invasive Detection of Gene Alterations in Non-Small Cell Lung Cancer.

ACS Appl Mater Interfaces 2019 Mar 20. Epub 2019 Mar 20.

Tumor-derived extracellular vesicles (EVs) present in bodily fluids are emerging liquid biopsy markers for non-invasive cancer diagnosis and treatment monitoring. Since the majority of EVs in circulation are not of tumor origin, it is critical to develop new platforms capable of enriching tumor-derived EVs from the blood. Herein, we introduce a biostructure-inspired NanoVilli Chip, capable of highly efficient and reproducible immunoaffinity capture of tumor-derived EVs from blood plasma samples. Read More

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http://dx.doi.org/10.1021/acsami.9b01406DOI Listing

Utility and safety of endobronchial ultrasound-guided transbronchial needle aspiration and endoscopic ultrasound with an echobronchoscope-guided fine needle aspiration in children with mediastinal pathology.

Pediatr Pulmonol 2019 Mar 19. Epub 2019 Mar 19.

Division of Pediatric Pulmonology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound with an echobronchoscope-guided fine needle aspiration (EUS-B-FNA) are useful modalities in the evaluation of mediastinal pathologies in adults. However, sparse data are available in children.

Objective: To describe the utility and safety of EBUS-TBNA and EUS-B-FNA in children with mediastinal pathologies of unknown etiology. Read More

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http://dx.doi.org/10.1002/ppul.24313DOI Listing

Maintaining the benefits following pulmonary rehabilitation: Achievable or not?

Respirology 2019 Mar 19. Epub 2019 Mar 19.

Faculty of Health Sciences, The University of Sydney, Sydney, NSW, Australia.

Pulmonary rehabilitation (PR) improves exercise capacity, health-related quality of life (HRQoL) and dyspnoea in patients with COPD and other lung conditions. Once PR is completed, the benefits gained begin to decline unless patients continue to exercise regularly. Due to limited evidence in other lung conditions, this review aims to examine the current evidence regarding maintenance exercise programmes for patients with COPD and to determine the types of programmes that are able to maintain the benefits gained from PR to 12 months and longer. Read More

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http://dx.doi.org/10.1111/resp.13518DOI Listing
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