877,069 results match your criteria Lungs


A Fusion Protein of Derp2 Allergen and Flagellin Suppresses Experimental Allergic Asthma.

Allergy Asthma Immunol Res 2019 Mar;11(2):254-266

Clinical Vaccine R&D Center and Department of Microbiology, Chonnam National University Medical School, Gwangju, Korea.

Purpose: The house dust mite (HDM) is one of the most important sources of indoor allergens and a significant cause of allergic rhinitis and allergic asthma. Our previous studies demonstrated that flagellin B (FlaB) plus allergen as a co-treatment mixture improved lung function and inhibited eosinophilic airway inflammation through the Toll-like receptor 5 signaling pathway in an ovalbumin (OVA)- or HDM-induced mouse asthma model. In the present study, we fused the major mite allergen Derp2 to FlaB and compared the therapeutic effects of the Derp2-FlaB fusion protein with those of a mixture of Derp2 and FlaB in a Derp2-induced mouse asthma model. Read More

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http://dx.doi.org/10.4168/aair.2019.11.2.254DOI Listing

Update on the Management of Occupational Asthma and Work-Exacerbated Asthma.

Allergy Asthma Immunol Res 2019 Mar;11(2):188-200

Respiratory Division, Department of Medicine, Toronto Western Hospital and St. Michael's Hospital, Toronto, Ontario, Canada.

Work-related asthma is the most common occupational lung disease encountered in clinical practice. In adult asthmatics, work-relatedness can account for 15%-33% of cases, but delays in diagnosis remain common and lead to worse outcomes. Accurate diagnosis of asthma is the first step to managing occupational asthma, which can be sensitizer-induced or irritant-induced asthma. Read More

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http://dx.doi.org/10.4168/aair.2019.11.2.188DOI Listing

The efficacy and safety of azithromycin in asthma: A systematic review.

J Cell Mol Med 2019 Jan 19. Epub 2019 Jan 19.

Department of Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Azithromycin is a potential therapeutic choice for asthma control, which is a heterogeneous airway inflammatory disease. Because of variable findings, we intend to evaluate the therapeutic effect and safety of azithromycin in asthma. Databases, including PubMed, EMBASE, Cochrane, and CNKI until 31 December 2017, were searched to identify available randomised controlled trials regarding azithromycin treatment for asthma. Read More

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http://dx.doi.org/10.1111/jcmm.13919DOI Listing
January 2019

Assessment of baseline symptom burden in treatment-naïve patients with lung cancer: an observational study.

Support Care Cancer 2019 Jan 19. Epub 2019 Jan 19.

Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 432, Houston, TX, 77030, USA.

Background: Patients with newly diagnosed lung cancer who have not yet begun treatment may already be experiencing major symptoms produced by their disease. Understanding the symptomatic effects of cancer treatment requires knowledge of pretreatment symptoms (both severity and interference with daily activities). We assessed pretreatment symptom severity, interference, and quality of life (QOL) in treatment-naïve patients with lung cancer and report factors that correlated with symptom severity. Read More

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http://dx.doi.org/10.1007/s00520-018-4632-0DOI Listing
January 2019

Pulmonary lung Doppler signals: normative data in a pediatric population compared with adults.

J Clin Monit Comput 2019 Jan 19. Epub 2019 Jan 19.

Stanford Children's Hospital, Palo Alto, CA, USA.

Lung Doppler signals (LDS) acquired via transthoracic echocardiography is a novel technology previously reported in adults for use in detecting pulmonary hypertension. The aim of this study was to characterize LDS in healthy children to establish normative pediatric LDS data, and compare the pediatric data to the previously published healthy adult LDS. In this prospective, two-center study, LDS were acquired in children without cardiopulmonary disease using a 2 MHz transthoracic pulsed Doppler transducer. Read More

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http://dx.doi.org/10.1007/s10877-019-00258-3DOI Listing
January 2019

EGFR plasma mutation in prediction models for resistance with EGFR TKI and survival of non-small cell lung cancer.

Clin Transl Med 2019 Jan 19;8(1). Epub 2019 Jan 19.

Clinical Cancer Center, Cho Ray Hospital, Ho Chi Minh City, 700000, Vietnam.

Background: This study aims to clarify the prognostic role of epidermal growth factor receptor (EGFR) mutations in plasma of non-small cell lung cancer (NSCLC) for resistance to tyrosine kinase inhibitor (TKI), in correlation with clinical characteristics. A total of 94 Adenocarcinoma, clinical stage IV NSCLC patients with either E19del or L858R mutation were admitted to the prospective study from Jan-2016 to Jul-2018. EGFR mutations in plasma were detected by scorpions ARMS method. Read More

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http://dx.doi.org/10.1186/s40169-019-0219-8DOI Listing
January 2019

GLRX inhibition enhances the effects of geftinib in EGFR-TKI-resistant NSCLC cells through FoxM1 signaling pathway.

J Cancer Res Clin Oncol 2019 Jan 19. Epub 2019 Jan 19.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai, 200032, China.

Purpose: Non-small-cell lung cancer (NSCLC) is the most common form of lung cancer. Gefitinib is one of the most accepted therapies against NSCLC in those carrying EGFR mutations, but it is only effective in approximately 20% of patients with NSCLC. Thus, alternative therapeutic interventions are urgently needed to overcome gefitinib resistance. Read More

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http://link.springer.com/10.1007/s00432-019-02845-y
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http://dx.doi.org/10.1007/s00432-019-02845-yDOI Listing
January 2019
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Fetoscopic versus Ultrasound-Guided Intravascular Delivery of Maternal Bone Marrow Cells in Fetal Macaques: A Technical Model for Intrauterine Haemopoietic Cell Transplantation.

Fetal Diagn Ther 2019 Jan 18:1-12. Epub 2019 Jan 18.

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Introduction: Significant limitations with existing treatments for major haemoglobinopathies motivate the development of effective intrauterine therapy. We assessed the feasibility of fetoscopic and ultrasound-guided intrauterine haemopoietic cell transplantation (IUHCT) in macaque fetuses in early gestation when haemopoietic and immunological ontogeny is anticipated to enable long-term donor cell engraftment.

Material And Methods: Fluorescent-labelled bone marrow-derived mononuclear cells from 10 pregnant Macaca fascicularis were injected into their fetuses at E71-114 (18. Read More

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http://dx.doi.org/10.1159/000493791DOI Listing
January 2019

External beam accelerated partial breast irradiation: dosimetric assessment of conformal and three different intensity modulated techniques.

Radiol Oncol 2019 Jan 19. Epub 2019 Jan 19.

Center of Radiotherapy, National Institute of Oncology, Budapest, Hungary.

Background The aim of the study was to evaluate and compare four different external beam radiotherapy techniques of accelerated partial breast irradiation (APBI) considering target coverage, dose to organs at risk and overall plan quality. The investigated techniques were three dimensional conformal radiotherapy (3D-CRT), "step and shoot" (SS) and "sliding window" (SW) intensity-modulated radiotherapy (IMRT), intensity-modulated arc therapy (RA). Patients and methods CT scans of 40 APBI patients were selected for the study. Read More

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http://dx.doi.org/10.2478/raon-2019-0001DOI Listing
January 2019

Identifying occupationally exposed populations for lung cancer screening: it is about time.

Authors:
Fraser Brims

Occup Environ Med 2019 Jan 19. Epub 2019 Jan 19.

Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1136/oemed-2018-105464DOI Listing
January 2019

Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis.

Thorax 2019 Jan 19. Epub 2019 Jan 19.

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.

Background: Mechanisms that facilitate early infection and inflammation in cystic fibrosis (CF) are unclear. We previously demonstrated that children with CF and parental-reported secondhand smoke exposure (SHSe) have increased susceptibility to bacterial infections. SHSe hinders arachidonic acid (AA) metabolites that mediate immune function in patients without CF, and may influence CF immune dysfunction. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-211845DOI Listing
January 2019

Wandering out of the GWAS wilderness: a new pathway paradigm for complex disease genetics.

Thorax 2019 Jan 19. Epub 2019 Jan 19.

Division of Pulmonary and Critical Care, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1136/thoraxjnl-2018-212511DOI Listing
January 2019

Impact of organisation and specialist service delivery on lung cancer outcomes.

Thorax 2019 Jan 19. Epub 2019 Jan 19.

Department of Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, Birmingham, UK.

Introduction: Data from the National Lung Cancer Audit (NLCA) often show variation in outcomes between lung cancer units which are not entirely explained by case mix. We explore the association between the organisation of services and patient outcome.

Methods: Details of service provision were collected via an electronic survey in June 2017. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-212588DOI Listing
January 2019

Clinical challenges in a patient with two BRAF V600E-mutated diseases.

Thorax 2019 Jan 19. Epub 2019 Jan 19.

Internal Medicine II, Pneumology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1136/thoraxjnl-2018-212481DOI Listing
January 2019

Early specialist palliative care on quality of life for malignant pleural mesothelioma: a randomised controlled trial.

Thorax 2019 Jan 19. Epub 2019 Jan 19.

Department of Respiratory, Queen Alexandra Hospital, Portsmouth, Hampshire, UK.

Purpose: Malignant pleural mesothelioma (MPM) has a high symptom burden and poor survival. Evidence from other cancer types suggests some benefit in health-related quality of life (HRQoL) with early specialist palliative care (SPC) integrated with oncological services, but the certainty of evidence is low.

Methods: We performed a multicentre, randomised, parallel group controlled trial comparing early referral to SPC versus standard care across 19 hospital sites in the UK and one large site in Western Australia. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-212380DOI Listing
January 2019

Exercise Training Induces Depot-Specific Adaptations to White and Brown Adipose Tissue.

iScience 2019 Jan 3;11:425-439. Epub 2019 Jan 3.

Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12(th) Avenue, Columbus, OH 43210, USA. Electronic address:

Exercise affects whole-body metabolism through adaptations to various tissues, including adipose tissue (AT). Recent studies investigated exercise-induced adaptations to AT, focusing on inguinal white adipose tissue (WAT), perigonadal WAT, and interscapular brown adipose tissue (iBAT). Although these AT depots play important roles in metabolism, they account for only ∼50% of the AT mass in a mouse. Read More

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http://dx.doi.org/10.1016/j.isci.2018.12.033DOI Listing
January 2019

Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model.

J Nutr Biochem 2018 Dec 21;65:93-100. Epub 2018 Dec 21.

Department of Biological Sciences, Laboratory of Experimental Pathophysiology, Federal University of Ouro Preto, Minas Gerais, Brazil. Electronic address:

Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease characterized by a non-fully reversible airflow limitation comprising chronic bronchitis and pulmonary emphysema both being induced by cigarette smoke (CS) exposure. Lycopene has shown antioxidant and anti-inflammatory properties that can prevent acute lung inflammation and emphysema. We hypothesized that administration with lycopene would repair lung damage in emphysema caused by CS exposure. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2018.12.008DOI Listing
December 2018

Optical aptasensor based on silver nanoparticles for the colorimetric detection of adenosine.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Jan 16;213:1-5. Epub 2019 Jan 16.

Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran. Electronic address:

A new and straightforward optical sensor for the colorimetric determination of adenosine (AD) in human urine samples was developed. The sensor comprised silver nanoparticles (AgNPs) as colorimetric elements and anti-AD aptamer (AP) as a recognition probe. In a solution containing AD and high concentration of NaCl, due to the unique binding of AD with AP, the aggregated metal nanomaterials dispersed in the solution, and the color intensity of the solution was changed accordingly. Read More

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http://dx.doi.org/10.1016/j.saa.2019.01.036DOI Listing
January 2019

Learning to detect chest radiographs containing pulmonary lesions using visual attention networks.

Med Image Anal 2019 Jan 9;53:26-38. Epub 2019 Jan 9.

Department of Biomedical Engineering, King's College London, London, UK. Electronic address:

Machine learning approaches hold great potential for the automated detection of lung nodules on chest radiographs, but training algorithms requires very large amounts of manually annotated radiographs, which are difficult to obtain. The increasing availability of PACS (Picture Archiving and Communication System), is laying the technological foundations needed to make available large volumes of clinical data and images from hospital archives. Binary labels indicating whether a radiograph contains a pulmonary lesion can be extracted at scale, using natural language processing algorithms. Read More

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http://dx.doi.org/10.1016/j.media.2018.12.007DOI Listing
January 2019

Takotsubo cardiomyopathy and neurogenic pulmonary edema after carotid endarterectomy.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurosurgery, Brain Attack Center, Ota Memorial Hospital, Fukuyama, Hiroshima, Japan.

Background: Takotsubo cardiomyopathy (TCM) and neurogenic pulmonary edema (NPE) are rare complications of an acute ischemic stroke. In particular, TCM and NPE, following carotid endarterectomy (CEA) are extremely rare. In general, TCM- and NPE-associated ischemic strokes are caused by excess catecholamine release after sympathetic nervous stimulation following stroke onset, but the mechanism triggering this stimulation is still unknown. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.206DOI Listing
January 2019

Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.

Int Immunopharmacol 2019 Jan 17;69:11-18. Epub 2019 Jan 17.

Department of Anesthesia, Tianjin Medical University General Hospital, Tianjin, China. Electronic address:

Background: Lung injury is a vital contributor of mortality in septic patients. Our previous studies have found that molecular hydrogen (H), which has anti-oxidant, anti-inflammatory, and anti-apoptosis effects, had a therapeutic effect on a septic animal model through increasing expression of nuclear factor-erythroid 2-related factor 2 (Nrf2). The aim of this research was to investigate the effects of 2% H gas inhalation on sepsis-induced lung injury and its underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.022DOI Listing
January 2019

Cyanidin-3-O-β-glucoside attenuates allergic airway inflammation by modulating the IL-4Rα-STAT6 signaling pathway in a murine asthma model.

Int Immunopharmacol 2019 Jan 17;69:1-10. Epub 2019 Jan 17.

Department of Otolaryngology, Guangzhou Women and Children Medical Centre, Guangzhou, China. Electronic address:

Cyanidin-3-O-β-glucoside (Cy-3-g), a typical and abundant monomer of anthocyanins, exhibits a variety of biological activities, such as anti-atherosclerosis, anti-obesity, and anticancer effects. However, to date little is known about its effects on asthma. This study aimed to investigate the efficacy of dietary Cy-3-g on allergic asthma in an animal model. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.008DOI Listing
January 2019

Analysis of motor and respiratory function in Duchenne muscular dystrophy patients.

Respir Physiol Neurobiol 2019 Jan 17. Epub 2019 Jan 17.

Department of Pediatrics, School of Medical Sciences, University of Campinas, 13081-970, P.O. Box: 6111 Campinas, São Paulo, Brazil; Laboratory of Pulmonary Physiology, Center for Pediatrics Investigation, School of Medical Sciences, University of Campinas, 13081-970, P.O. Box: 6111 Campinas, São Paulo, Brazil. Electronic address:

Introduction: Duchenne muscular dystrophy(DMD) shows motor and respiratory impairment.

Methods: 19 DMD patients(DMDG) (nine ambulatory and 10 non-ambulatory) were evaluated through motor function measure(MFM), 6-minute walk test(6MWT), respiratory muscle strength, cough peak flow, spirometry and volumetric capnography(VCap) tools. Control group that performed spirometry and VCap(CG1-n = 17) were different from those that performed the 6MWT(CG2-n = 8). Read More

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http://dx.doi.org/10.1016/j.resp.2019.01.009DOI Listing
January 2019

Borderline pulmonary hypertension associated with chronic hypercapnia in chronic pulmonary disease.

Respir Physiol Neurobiol 2019 Jan 17. Epub 2019 Jan 17.

Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.

Pulmonary hypertension (PH) due to lung diseases is classified as group 3 by the Dana Point classification. Given the basic pathophysiological conditions of group 3 lung diseases and the previously well-known concept of hypercapnic pulmonary vasoconstriction, chronic hypercapnia besides alveolar hypoxia might be another causative factor to increase mean pulmonary arterial pressure (PAm). Two hundred twenty-five subjects with chronic pulmonary diseases were assessed by a right heart catheterization and blood gas parameters. Read More

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http://dx.doi.org/10.1016/j.resp.2019.01.003DOI Listing
January 2019

Expediting Comprehensive Molecular Analysis to Optimize Initial Treatment of Lung Cancer Patients with Minimal Smoking History.

J Thorac Oncol 2019 Jan 17. Epub 2019 Jan 17.

Massachusetts General Hospital, Center for Integrated Diagnostics.

Purpose: Lung cancer patients with tumors harboring actionable alterations can achieve very durable responses to first-line targeted therapy. However, identifying targetable alterations using next-generation sequencing (NGS) is a complex and time-intensive process. As actionable genetic alterations are enriched in lung cancers arising in patients with limited smoking history, we designed a workflow to expedite NGS testing for this group. Read More

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http://dx.doi.org/10.1016/j.jtho.2018.12.032DOI Listing
January 2019

Integrating Genomics into Management of Fibrotic Interstitial Lung Disease.

Chest 2019 Jan 17. Epub 2019 Jan 17.

Division of Pulmonary & Critical Care & Sleep Medicine, Department of Medicine, University of Virginia.

Fibrotic interstitial lung diseases have a high mortality rate with an unpredictable disease course and clinical features that frequently overlap. Recent data indicate important roles for genomics in the mechanisms underlying susceptibility and progression of pulmonary fibrosis, and the impact of these genomic markers on pharmacotherapy and their contribution to outcomes is increasingly recognized. Interstitial lung abnormalities, frequently considered representative of early interstitial lung disease (ILD), have been consistently associated with the MUC5B promoter polymorphism, a common gene variant. Read More

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http://dx.doi.org/10.1016/j.chest.2018.12.011DOI Listing
January 2019

Multiple respiratory microbiota profiles are associated with lower airway inflammation in children with protracted bacterial bronchitis.

Chest 2019 Jan 17. Epub 2019 Jan 17.

Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia; Department of Respiratory and Sleep Medicine, Queensland Children's Hospital and the Centre for Children's Health Research, Queensland University of Technology, Brisbane, Australia.

Background: Effective management of protracted bacterial bronchitis (PBB) is needed to prevent chronic disease (e.g. bronchiectasis). Read More

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http://dx.doi.org/10.1016/j.chest.2019.01.002DOI Listing
January 2019

Use of Computed Tomography to Quantify Progression and Response to Treatment in LAM.

Chest 2019 Jan 17. Epub 2019 Jan 17.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. Electronic address:

Background: In lymphangioleiomyomatosis (LAM), infiltration of the lungs with smooth muscle-like LAM cells results in cystic destruction and decline in lung function, effects stabilized by sirolimus therapy. LAM lung disease is followed, in part, by high-resolution computed tomography scans. To obtain further information from these scans, we quantified changes in lung parenchyma by analyzing image "texture". Read More

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http://dx.doi.org/10.1016/j.chest.2019.01.004DOI Listing
January 2019

Genetic polymorphisms in sepsis and cardiovascular disease Do similar risk genes suggest similar drug targets?

Chest 2019 Jan 17. Epub 2019 Jan 17.

University of British Columbia, Critical Care Research Laboratories, Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6.

Genetic variants are associated with altered clinical outcome of patients with sepsis and cardiovascular diseases. Common gene signaling pathways may be involved in the pathophysiology of these diseases. A better understanding of genetic commonality among these diseases may enable the discovery of important genes, signaling pathways and therapeutic targets for these diseases. Read More

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http://dx.doi.org/10.1016/j.chest.2019.01.003DOI Listing
January 2019

Adding a LAMA to ICS/LABA therapy: a meta-analysis of triple therapy in COPD.

Chest 2019 Jan 17. Epub 2019 Jan 17.

Unit of Respiratory Medicine, Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.

Background: Inhaled corticosteroid (ICS)/long-acting β-agonist (LABA) combination commonly prescribed to treat chronic obstructive pulmonary disease (COPD). Therefore, we performed a meta-analysis on the impact of adding a long-acting muscarinic receptor antagonist (LAMA) to ICS/LABA combination in COPD.

Methods: Studies were identified by searching in different databases the randomized controlled trials (RCTs) that investigated the effect of ICS/LABA/LAMA combination in COPD. Read More

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http://dx.doi.org/10.1016/j.chest.2018.12.016DOI Listing
January 2019

A large scale proteome analysis of the gefitinib primary resistance overcome by KDAC inhibition in KRAS mutated adenocarcinoma cells overexpressing amphiregulin.

J Proteomics 2019 Jan 17. Epub 2019 Jan 17.

Univ. Grenoble Alpes, LBFA and BEeSy, PROMETHEE Proteomic Platform, Grenoble, France; Inserm, U1055, PROMETHEE Proteomic Platform, Grenoble, France; CHU Grenoble Alpes, Institut de Biologie et de Pathologie, PROMETHEE Proteomic Platform, Grenoble, France. Electronic address:

KDAC inhibitors (KDACi) overcome gefitinib primary resistance in non-small cell lung cancer (NSCLC) including mutant-KRAS lung adenocarcinoma. To identify which proteins are involved in the restoration of this sensitivity and to provide new therapeutic targets for mutant-KRAS lung adenocarcinoma, we performed an iTRAQ quantitative proteomic analysis after subcellular fractionation of H358-NSCLC treated with gefitinib and KDACi (TSA/NAM) versus gefitinib alone. The 86 proteins found to have been significantly dysregulated between the two conditions, were mainly involved in cellular metabolism and cell transcription processes. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.01.009DOI Listing
January 2019

Effects of intratracheal Fusarium solani inoculation in immunocompetent mice.

Microb Pathog 2019 Jan 17. Epub 2019 Jan 17.

Department of Clinical Analysis and Biomedicine, Laboratory of Medical Mycology, State University of Maringá, Brazil, Avenida. Colombo, 5790, CEP: 87020-900, Maringá, Paraná, Brazil. Electronic address:

Fusariosis is an infection that is caused by fungi of the Fusarium genus. It is the second most common fungus that is associated with human fungal infections, usually in immunocompromised individuals. The incidence of such infections has been increasing, including in immunocompetent hosts. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.01.020DOI Listing
January 2019

Traditional Chinese medicine Ze-Qi-Tang formula inhibit growth of non-small-cell lung cancer cells through the p53 pathway.

J Ethnopharmacol 2019 Jan 17. Epub 2019 Jan 17.

School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China. Electronic address:

Ethnopharmacological Relevance: Ze-Qi-Tang (ZQT), a classic Chinese herbal formula, has been for over thousand years used for the treatment of several respiratory ailments like cough, asthma, hydrothorax and lung cancer.

Aim Of Study: Cumulative literature on ZQT herbal formula reveals that its several constituent components are potent inducer of apoptosis in different cancer cells. However, the activity of ZQT against non-small-cell-lung cancer (NSCLC) has not been previously examined. Read More

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http://dx.doi.org/10.1016/j.jep.2019.01.007DOI Listing
January 2019

Oral coadministration of elacridar and ritonavir enhances brain accumulation and oral availability of the novel ALK/ROS1 inhibitor lorlatinib.

Eur J Pharm Biopharm 2019 Jan 17. Epub 2019 Jan 17.

The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address:

Lorlatinib, a novel generation oral anaplastic lymphoma kinase (ALK) and ROS1 inhibitor with high membrane and blood-brain barrier permeability, recently received accelerated approval for treatment of ALK-rearranged non-small-cell lung cancer (NSCLC), and its further clinical development is ongoing. We previously found that the efflux transporter P-glycoprotein (MDR1/ABCB1) restricts lorlatinib brain accumulation and that the drug-metabolizing enzyme cytochrome P450-3A (CYP3A) limits its oral availability. Using genetically modified mouse models, we investigated the impact of targeted pharmacological inhibitors on lorlatinib pharmacokinetics and bioavailability. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.01.016DOI Listing
January 2019

miR-140-3p functions as a tumor suppressor in squamous cell lung cancer by regulating BRD9.

Cancer Lett 2019 Jan 17. Epub 2019 Jan 17.

Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science & Technology of China, Hefei, 230026, China. Electronic address:

Squamous cell lung cancer (SqCLC) is among the most malignant lung cancers worldwide, lacking biomarkers for diagnostic and targets for treatment. In this study, we observed that miR-140-3p was expressed at low levels in both in SqCLC cell lines and patient samples, while overexpression of miR-140-3p dramatically reduced the cell proliferation and invasion in SqCLC cells and Patient derived xenograft (PDX) models. Our further investigation indicated miR-140-3p negatively affected the tumorigenesis of SqCLC by down-regulating the expression of BRD9, an oncogene in SqCLC. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.01.007DOI Listing
January 2019

Hypoxia Enhances CD8+ Tc2 Dependent Airway Hyperresponsiveness and Inflammation Through Hypoxia Inducible Factor 1α.

J Allergy Clin Immunol 2019 Jan 17. Epub 2019 Jan 17.

Division of Cell Biology, Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, Colorado 80206, USA. Electronic address:

Background: CD8+ T cells (Tc2) become potent, steroid-insensitive pathogenic effector cells in experimental asthma undergoing transcriptional reprogramming to IL-13 production in the presence of IL-4. However, no studies have described the effects of hypoxia exposure on Tc2 differentiation.

Objective: We determined the effects of hypoxia exposure on IL-13-producing CD8+ Tc2 cells. Read More

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http://dx.doi.org/10.1016/j.jaci.2018.11.049DOI Listing
January 2019

Gamma tocopherol effect on LPS-induced sputum neutrophilia is not modified by BMI or GSTM1 genotype.

J Allergy Clin Immunol 2019 Jan 17. Epub 2019 Jan 17.

Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, NC; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of North Carolina, Chapel Hill, NC.

Gamma tocopherol may be beneficial as a primary or complementary therapeutic agent in conditions with neutrophilic airway inflammation. Its effects are not modified by BMI or GSTM1 genotype, allowing for its use in a broader population. Read More

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http://dx.doi.org/10.1016/j.jaci.2018.12.1009DOI Listing
January 2019

Is the T-T interval as a measure of repolarization heterogeneity dead or just seriously wounded?

Heart Rhythm 2019 Jan 17. Epub 2019 Jan 17.

Department of Cardiology and Pneumology - Heart Center University of Göttingen Medical Center,Göttingen, Germany.

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http://dx.doi.org/10.1016/j.hrthm.2019.01.015DOI Listing
January 2019

Native T Mapping in the Diagnosis of Cardiac Allograft Rejection: A Prospective Histologically Validated Study.

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Heart and Lung Transplant Unit, St. Vincent's Hospital, Sydney, Australia.

Objectives: This study aimed to determine the role of T mapping in identifying cardiac allograft rejection.

Background: Endomyocardial biopsy (EMBx), the current gold standard to diagnose cardiac allograft rejection, is associated with potentially serious complications. Cardiac magnetic resonance (CMR)-based T mapping detects interstitial edema and fibrosis, which are important markers of acute and chronic rejection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X183107
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http://dx.doi.org/10.1016/j.jcmg.2018.10.027DOI Listing
January 2019
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Sex Differences in Coronary Artery and Thoracic Aorta Calcification and Their Association With Cardiovascular Mortality in Heavy Smokers.

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands.

Objectives: The aim of this study was to investigate sex differences in the prevalence, extent, and association of coronary artery calcium (CAC) and thoracic aorta calcium (TAC) scores with cardiovascular mortality in a population eligible for lung screening.

Background: CAC and TAC scores derived from chest computed tomography (CT) might be useful biomarkers for individualized cardiovascular disease prevention and could be especially relevant in high-risk populations such as heavy smokers. Therefore, it is important to know the prevalence of arterial calcifications in male and female heavy smokers, and if there are differences in the predictive value calcifications carry. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.10.026DOI Listing
January 2019

Assessment of Subclinical Atherosclerosis in Smokers: Does Lower Risk Mean Low Risk?

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

From the Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Minneapolis, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2018.12.004DOI Listing
January 2019

Intracuff pressure during one-lung ventilation in infants and children.

J Pediatr Surg 2018 Dec 28. Epub 2018 Dec 28.

Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH; Department of Anesthesiology & Pain Medicine, The Ohio State University College of Medicine, Columbus, OH.

Objective: We prospectively evaluated intracuff pressure (IP) during one-lung ventilation (OLV) to characterize potential risk associated with overinflation of the cuff used for OLV.

Design: Prospective observational study over a 2-year period, in infants and children undergoing thoracic surgery. The IPs of the tracheal and bronchial balloon were measured using a manometer and compared to a previously recommended threshold of 30 cmH2O. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.10.110DOI Listing
December 2018

Long peripheral catheters for deep arm vein venous access: A systematic review of complications.

Authors:
James Badger

Heart Lung 2019 Jan 16. Epub 2019 Jan 16.

Honorary Academic Research Trainee, University of Southampton NHS Trust, University of Southampton, University Road, Southampton, SO171BJ, United Kingdom. Electronic address:

Purpose: Long peripheral catheters (LPCs) offer a quick, simple and cost-effective alternative for venous access in intensive care patients with difficult venous access, but the decision to use them must be balanced against an assessment of harm. The aim of this systematic review was to synthesise reports of complications associated with LPCs.

Methods: The electronic datab\ases MEDLINE, EMBASE and CINAHL were searched systematically for randomised controlled trials, cohort studies and case control studies published in the period 1966 to 24th July 2018 reporting LPC associated occlusion, catheter related blood stream infections, phlebitis and infiltration. Read More

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http://dx.doi.org/10.1016/j.hrtlng.2019.01.002DOI Listing
January 2019

Integrated respiratory and palliative care leads to high levels of satisfaction: a survey of patients and carers.

BMC Palliat Care 2019 Jan 19;18(1). Epub 2019 Jan 19.

Chair of Palliative Medicine, University of Melbourne, St Vincent's Hospital and Victorian Comprehensive Cancer Centre, Melbourne, Australia.

Background: The Advanced Lung Disease Service is a unique, new model of integrated respiratory and palliative care, which aims to address the unmet needs of patients with advanced, non-malignant, respiratory diseases. This study aimed to explore patients' and carers' experiences of integrated palliative care and identify valued aspects of care.

Methods: All current patients of the integrated service and their carers were invited to complete a confidential questionnaire by post or with an independent researcher. Read More

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http://dx.doi.org/10.1186/s12904-019-0390-0DOI Listing
January 2019

Retraction Note to: Synthesis, characterization and in vitro studies of doxorubicin-loaded magnetic nanoparticles grafted to smart copolymers on A549 lung cancer cell line.

J Nanobiotechnology 2019 Jan 19;17(1). Epub 2019 Jan 19.

Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.

The Editors have retracted this article [1] because Figs. 6a and 6c have been used in three other publications to represent scanning electron micrographs of different nanoparticles [2-4]. The data reported in this article are therefore unreliable. Read More

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http://dx.doi.org/10.1186/s12951-018-0434-2DOI Listing
January 2019
4.078 Impact Factor

Leisure-time physical activity and DNA methylation age-a twin study.

Clin Epigenetics 2019 Jan 19;11(1):12. Epub 2019 Jan 19.

Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, P.O. Box 35 (VIV), FI-40014, Jyväskylä, Finland.

Background: Epigenetic clocks may increase our understanding on human aging and how genetic and environmental factors regulate an individual aging process. One of the most promising clocks is Horvath's DNA methylation (DNAm) age. Age acceleration, i. Read More

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http://dx.doi.org/10.1186/s13148-019-0613-5DOI Listing
January 2019

S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension.

Redox Biol 2019 Jan 7;21:101099. Epub 2019 Jan 7.

Institute of Cardiovascular Science, Peking University Health Science Center, Beijing 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China. Electronic address:

Krüppel-like factor 4 (KLF4) is a transcription factor with conserved zinc finger domains. As an essential regulator of vascular homeostasis, KLF4 exerts a protective effect in endothelial cells (ECs), including regulating vasodilation, inflammation, coagulation and oxidative stress. However, the underlying mechanisms modifying KLF4 activity in mediating vascular function remain poorly understood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183080
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http://dx.doi.org/10.1016/j.redox.2019.101099DOI Listing
January 2019
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Bioavailability of endotracheal epinephrine in an ovine model of neonatal resuscitation.

Early Hum Dev 2019 Jan 15;130:27-32. Epub 2019 Jan 15.

Department of Pediatrics, UC Davis School of Medicine, Sacramento, CA, United States of America.

Background: Distressed infants in the delivery room and those that have completed postnatal transition are both resuscitated according to established neonatal resuscitation guidelines, often with endotracheal (ET) epinephrine at the same dose. We hypothesized that ET epinephrine would have higher bioavailability in a post-transitional compared to transitioning newborn model due to absence of fetal lung liquid and intra-cardiac shunts.

Methods: 15 term fetal (transitioning newborn) and 6 postnatal lambs were asphyxiated by umbilical cord and ET tube occlusion respectively. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2019.01.006DOI Listing
January 2019

Brief Report: Clinical Utility of Cerebrospinal Fluid Cell Free-DNA as Liquid Biopsy for Leptomeningeal Metastases in ALK-Rearranged NSCLC.

J Thorac Oncol 2019 Jan 16. Epub 2019 Jan 16.

Guangdong General Hospital, School of Medicine, South China University of Technology, Guangzhou, China; Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

Introduction: Leptomeningeal metastases (LM) indicated a poor prognosis in non-small cell lung cancer (NSCLC). LM were more frequent in driver gene-mutated patients, and cerebrospinal fluid (CSF) cell-free DNA has shown unique genetic profiles of LM in EGFR mutated LM. However, studies in ALK-rearranged NSCLC patients with LM are scarce. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.01.007DOI Listing
January 2019
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