849,526 results match your criteria Lung cancer Amsterdam Netherlands[Journal]


A novel in vitro model of primary human pediatric lung epithelial cells.

Pediatr Res 2019 Feb 18. Epub 2019 Feb 18.

Division of Neonatology, University of Rochester Medical Center, Rochester, NY, USA.

Background: Current in vitro human lung epithelial cell models derived from adult tissues may not accurately represent all attributes that define homeostatic and disease mechanisms relevant to the pediatric lung.

Methods: We report methods for growing and differentiating primary Pediatric Human Lung Epithelial (PHLE) cells from organ donor infant lung tissues. We use immunohistochemistry, flow cytometry, quantitative RT-PCR, and single cell RNA sequencing (scRNAseq) analysis to characterize the cellular and transcriptional heterogeneity of PHLE cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41390-019-0340-9DOI Listing
February 2019

McSART: an iterative model-based, motion-compensated SART algorithm for CBCT reconstruction.

Phys Med Biol 2019 Feb 18. Epub 2019 Feb 18.

Radiation Oncology, University of California Los Angeles David Geffen School of Medicine, 200 Medical Plaza, Suite B265, Los Angeles, California, 90095, UNITED STATES.

4D cone beam computed tomography (CBCT) images of the thorax and abdomen can have reduced quality due to the limited number of projections per respiratory bin used in gated image reconstruction. In this work, we present a new algorithm to reconstruct high quality CBCT images by simultaneously reconstructing images and generating an associated respiratory motion model. This is done by updating model parameters to compensate for motion during the iterative image reconstruction process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6560/ab07d6DOI Listing
February 2019

Quantifying lung ultrasound comets with a convolutional neural network: Initial clinical results.

Comput Biol Med 2019 Feb 7;107:39-46. Epub 2019 Feb 7.

Biomedical Engineering, School of Science and Engineering, Tulane University, New Orleans, LA, USA. Electronic address:

Lung ultrasound comets are "comet-tail" artifacts appearing in lung ultrasound images. They are particularly useful in detecting several lung pathologies and may indicate the amount of extravascular lung water. However, the comets are not always well defined and large variations in the counting results exist between observers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.compbiomed.2019.02.002DOI Listing
February 2019

Novel hybrids of podophyllotoxin and formononetin inhibit the growth, migration and invasion of lung cancer cells.

Bioorg Chem 2019 Feb 6;85:445-454. Epub 2019 Feb 6.

Generic Drug Research Center of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi 563003, PR China. Electronic address:

In this study, three hybrids of podophyllotoxin and formononetin were synthesized and evaluated for anticancer efficacy. Some of the derivatives exhibited potent cytotoxicity against a panel of human and mouse cancer cell lines, with IC values in the low micromolar to submicromolar range. Evaluation against A549 lung tumor cell line identified that the IC value of compound 10a was 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2019.02.019DOI Listing
February 2019
2.152 Impact Factor

Access to second-line drug susceptibility testing results among patients with Rifampicin resistant tuberculosis after introduction of the Hain Line Probe Assay in Southern provinces, Zimbabwe.

Int J Infect Dis 2019 Feb 15. Epub 2019 Feb 15.

International Union Against Tuberculosis and Lung Disease (The Union), Paris, France; London School of Hygiene and Tropical Medicine, London, UK.

Objectives: To determine the proportion of rifampicin-resistant tuberculosis (RR-TB) patients who accessed second-line drug susceptibility testing (SL-DST) results following introduction of the Hain technology in southern provinces, Zimbabwe.

Design: Cohort study using secondary data.

Results: Xpert MTB/RIF results were used to identify 133 RR-TB patients for this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2019.02.007DOI Listing
February 2019

Precision-cut lung slices from bleomycin treated animals as a model for testing potential therapies for idiopathic pulmonary fibrosis.

Pulm Pharmacol Ther 2019 Feb 15. Epub 2019 Feb 15.

Fidelta Ltd., Prilaz baruna Filipovića 29, 10000, Zagreb, Croatia.

Idiopathic pulmonary fibrosis (IPF) is a complex lung disease with incompletely understood pathophysiology. Effectiveness of available medicines is limited and the need for new and improved therapies remains. Due to complexity of the disease, it is difficult to develop predictable in vitro models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pupt.2019.02.005DOI Listing
February 2019

Exploring on the bioactive markers of Codonopsis Radix by correlation analysis between chemical constituents and pharmacological effects.

J Ethnopharmacol 2019 Feb 15. Epub 2019 Feb 15.

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, People's Republic of China. Electronic address:

Ethnopharmacological Relevance: Codonopsis Radix is a commonly used traditional Chinese medicine, and has the effect of strengthening spleen and tonifying lung, nourishing blood and engendering liquid. In addition, it is also used as important food materials.

Aim Of The Study: The aim of the study was to explain the underlying correlations between chemical constituents and pharmacological effects and explore the bioactive markers of Codonopsis Radix. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.032DOI Listing
February 2019

CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance.

Eur J Pharm Sci 2019 Feb 15. Epub 2019 Feb 15.

CYP Design Ltd, The Innovation Centre, 49 Oxford Street, Leicester LE1 5XY, UK. Electronic address:

Microsomal cytochrome P450 (CYP) enzymes, isolated from recombinant bacterial/insect/yeast cells, are extensively used for drug metabolism studies. However, they may not always portray how a developmental drug would behave in human cells with intact intracellular transport mechanisms. This study emphasizes the usefulness of human HEK293 kidney cells, grown in 'suspension' for expression of CYPs, in finding potent CYP1A1/CYP1B1 inhibitors, as possible anticancer agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejps.2019.02.016DOI Listing
February 2019

Cost-effectiveness of web-based patient-reported outcome surveillance in lung cancer patients.

J Thorac Oncol 2019 Feb 15. Epub 2019 Feb 15.

Department of radiation oncology, Jean Bernard center, Inter-regional Institute of Oncology, Le Mans, France.

Background: A multicenter randomized clinical trial in France found an overall survival benefit of web-based patient-reported outcome (PRO)-based surveillance following initial treatment for lung cancer compared with conventional surveillance. The aim of this study was to assess the cost-effectiveness of this PRO-based surveillance in lung cancer patients.

Methods: This medico-economic analysis employed data from the clinical trial, augmented by abstracted chart data and costs of consultations, imaging, transportations, information technology, and treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtho.2019.02.005DOI Listing
February 2019
1 Read

Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury.

J Mol Cell Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Center for Metabolism and Mitochondrial Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

GCN5L1 regulates mitochondrial protein acetylation, cellular bioenergetics, reactive oxygen species (ROS) generation, and organelle positioning in a number of diverse cell types. However, the functional role of GCN5L1 in the heart is currently unknown. As many of the factors regulated by GCN5L1 play a major role in ischemia-reperfusion (I/R) injury, we sought to determine if GCN5L1 is an important nexus in the response to cardiac ischemic stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2019.02.009DOI Listing
February 2019

Prospective Multicentered Safety and Feasibility Pilot for Endobronchial Intratumoral Chemotherapy.

Chest 2019 Feb 15. Epub 2019 Feb 15.

Section of Interventional Pulmonology, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University, Durham, NC.

Background: Malignant airway obstruction (MAO) occurs in 30% of patients with advanced stage lung cancer leading to debilitating dyspnea, cough and hemoptysis. Other than recanalization of the airways, these patients lack long-lasting palliative therapy. The goal of this study was to determine the safety and feasibility of local injection of paclitaxel into the airway wall with a novel microinjection catheter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2019.02.006DOI Listing
February 2019

Interaction of aminophylline with photoilluminated vitamin B2 leads to ROS mediated macromolecular damage and cell death in benzopyrene induced mice lung carcinoma.

Chem Biol Interact 2019 Feb 15. Epub 2019 Feb 15.

Department of Biochemistry, Faculty of Life Sciences, AMU, India. Electronic address:

Riboflavin (Rf) or vitamin B₂ is a known photosensitizer whose photophysical and photochemical properties are well established. Aminophylline (Am) is a phosphodiesterase inhibitor and is currently used as a bronchodilator. Although there are several reports of haemolytic and proteolytic interaction of photoilluminated riboflavin with aminophylline, the cytotoxicity of this system against malignant tissue is not well defined and fully unravelled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2019.02.003DOI Listing
February 2019

ATP redirects cytokine trafficking and promotes novel membrane TNF signaling via microvesicles.

FASEB J 2019 Feb 18:fj201802386R. Epub 2019 Feb 18.

Section of Anaesthetics, Pain Medicine, and Intensive Care, Faculty of Medicine, Chelsea and Westminster Hospital, Imperial College London, London, United Kingdom.

Cellular stress or injury induces release of endogenous danger signals such as ATP, which plays a central role in activating immune cells. ATP is essential for the release of nonclassically secreted cytokines such as IL-1β but, paradoxically, has been reported to inhibit the release of classically secreted cytokines such as TNF. Here, we reveal that ATP does switch off soluble TNF (17 kDa) release from LPS-treated macrophages, but rather than inhibiting the entire TNF secretion, ATP packages membrane TNF (26 kDa) within microvesicles (MVs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201802386RDOI Listing
February 2019

Infection Studies in Pigs and Porcine Airway Epithelial Cells Reveal an Evolution of A(H1N1)pdm09 Influenza A Viruses Toward Lower Virulence.

J Infect Dis 2019 Feb 18. Epub 2019 Feb 18.

Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Germany.

We analyzed the virulence of pandemic H1N1 2009 influenza A viruses in vivo and in vitro. Selected viruses isolated in 2009, 2010, 2014, and 2015 were assessed using an aerosol-mediated high-dose infection model for pigs as well as air-liquid interface cultures of differentiated airway epithelial cells. Using a dyspnea score, rectal temperature, lung lesions, and viral load in the lung as parameters, the strains from 2014-2015 were significantly less virulent than the strains isolated in 2009-2010. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jiy719DOI Listing
February 2019

Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure-Guided Strategy vs an Empirical High PEEP-Fio2 Strategy on Death and Days Free From Mechanical Ventilation Among Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

JAMA 2019 Feb 18. Epub 2019 Feb 18.

Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Importance: Adjusting positive end-expiratory pressure (PEEP) to offset pleural pressure might attenuate lung injury and improve patient outcomes in acute respiratory distress syndrome (ARDS).

Objective: To determine whether PEEP titration guided by esophageal pressure (PES), an estimate of pleural pressure, was more effective than empirical high PEEP-fraction of inspired oxygen (Fio2) in moderate to severe ARDS.

Design, Setting, And Participants: Phase 2 randomized clinical trial conducted at 14 hospitals in North America. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2019.0555DOI Listing
February 2019

Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Crosslinks.

J Med Chem 2019 Feb 18. Epub 2019 Feb 18.

Hybrid molecules are composed of two pharmacophores with different biological activities. Here, we conjugated phthalazine moieties (anti-angiogenetic pharmacophore) and bis(hydroxymethyl)pyrrole moieties (DNA crosslinking agent) to form a series of bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine hybrids. These conjugates were cytotoxic to a variety of cancer cell lines by inducing DNA damage, arresting cell cycle progression at the G2/M phase, triggering apoptosis and inhibiting vascular endothelial growth factor receptor 2 (VEGFR-2) in endothelial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.8b01689DOI Listing
February 2019

[Activity of metabolic enzymes of saliva with neuroendocrine tumors of the lung of various degrees of malignancy.]

Klin Lab Diagn 2018 ;63(11):677-682

University Hospital of Strasbourg, Strasbourg.

Up to the present time, problems of optimizing the methods of diagnosis and predicting the course of lung cancer, which occupies the leading positions in the structure of oncological diseases, remain topical. The purpose of the study was to study the characteristics of the activity of metabolic salivary enzymes in neuroendocrine tumors of the lung, depending on the degree of malignancy. In the casecontrol study, 156 people took part, divided into 2 groups: primary (neuroendocrine lung tumors, n=56) and control (conventionally healthy, n=100). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18821/0869-2084-2018-63-11-677-682DOI Listing
January 2018

Correlation between EGFR mutation status and F -fluorodeoxyglucose positron emission tomography-computed tomography image features in lung adenocarcinoma.

Thorac Cancer 2019 Feb 18. Epub 2019 Feb 18.

Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Background: The purpose of this study was to investigate an association between EGFR mutation status and F-fluorodeoxyglucose positron emission tomography-computed tomography ( F-FDG PET-CT) image features in lung adenocarcinoma.

Methods: Retrospective analysis of the data of 139 patients with lung adenocarcinoma confirmed by surgical pathology who underwent preoperative F-FDG PET-CT was conducted. Correlations between EGFR mutation status, clinical characteristics, and PET-CT parameters, including the maximum standardized uptake value (SUVmax), the mean of the SUV (SUVmean), the peak of the SUV (SUVpeak) of the primary tumor, and the ratio of SUVmax between the primary tumor and the mediastinal blood pool (SUVratio), were statistically analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1759-7714.12981DOI Listing
February 2019

Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy.

FEBS J 2019 Feb 18. Epub 2019 Feb 18.

Pharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

It is well established that biglycan, a small leucine-rich proteoglycan, acts as an extracellular matrix-derived danger signal in its soluble form. By binding to innate immunity Toll-like receptors (TLR) 2 and 4, biglycan initiates and perpetuates the inflammatory response. Previous work has conveyed that biglycan's role in inflammation extends far beyond its function as a canonical danger signal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/febs.14791DOI Listing
February 2019

Peripheral muscle strength is associated with lung function and functional capacity in patients with cystic fibrosis.

Physiother Res Int 2019 Feb 18:e1771. Epub 2019 Feb 18.

Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pri.1771DOI Listing
February 2019

Safety and effectiveness of alectinib in a real-world surveillance study in patients with ALK-positive NSCLC in Japan.

Cancer Sci 2019 Feb 18. Epub 2019 Feb 18.

Third Department of Internal Medicine, Division of Pulmonary Medicine & Medical Oncology, Wakayama Medical University, Wakayama, Japan.

We conducted a large-scale surveillance study as a post-marketing commitment to investigate safety and effectiveness of alectinib in patients with ALK-positive non-small-cell lung cancer (NSCLC) in Japan. Patients receiving 300mg twice-daily alectinib (September 2014 to June 2015) were monitored until termination of alectinib or completion of 18 months of treatment at 519 Japanese study sites. The primary endpoint was the incidence of adverse drug reactions (ADRs), which are important identified risks for alectinib in Japanese patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.13977DOI Listing
February 2019

Parvovirus B19-Induced Severe Anemia in Heart Transplant Recipients: Case Report and Review of the Literature.

Clin Transplant 2019 Feb 18:e13498. Epub 2019 Feb 18.

Department of Medicine and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California.

We report a case of a 64-year-old woman who developed transfusion-dependent anemia after cardiac transplantation, the etiology of which was unknown after initial comprehensive evaluation. At the suggestion of the Transplant Infectious Diseases consultant, microbial agents with red blood cell tropism pertinent to this patient such as Parvovirus B 19 (B19V) were investigated. The B19V viral load by PCR in peripheral blood was >100,000,000 copies/ml and after treatment with intravenous immunoglobulin (IVIG), her anemia resolved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ctr.13498DOI Listing
February 2019

SCUBA Medicine for otolaryngologists: Part I. Diving into SCUBA physiology and injury prevention.

Laryngoscope 2019 Feb 18. Epub 2019 Feb 18.

Department of Surgery, Division of Otolaryngology, University of Connecticut Health, Farmington, Connecticut, U.S.A.

Objectives: Introduce pertinent self-contained underwater breathing apparatus (SCUBA) physiology and corresponding terminology. Appreciate the scope of diving and related otolaryngological injury. Illustrate pathophysiologic mechanisms for diving injuries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.27867DOI Listing
February 2019

Epithelial barrier repair and prevention of allergy.

J Clin Invest 2019 Feb 18. Epub 2019 Feb 18.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, and.

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the release of type 2 cytokines that drive allergic inflammation. The accessibility of skin, compared with lung or gastrointestinal tissue, has facilitated detailed investigations into mechanisms underlying epithelial barrier dysfunction in atopic dermatitis (AD). This Review describes the formation of the skin barrier and analyzes the link between altered skin barrier formation and the pathogenesis of AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI124608DOI Listing
February 2019

Vascular Endothelial Growth Factor-D (VEGF-D) is Elevated in Bronchoalveolar Lavage Fluid of Patients with Lung Squamous Carcinoma.

Clin Lab 2019 Jan;65(1)

Background: Previous studies have found that vascular endothelial growth factor (VEGF) is associated with lung cancer, yet little is known about vascular endothelial growth factor-D (VEGF-D) in bronchoalveolar lavage fluid (BALF) of lung cancer patients. In this study, we aim to investigate the expression and evaluation of VEGF-D in BALF for lung cancer diagnosis.

Methods: BALF samples were acquired from 81 patients: 40 with benign diseases and 41 with lung cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7754/Clin.Lab.2018.180712DOI Listing
January 2019

Tuberculosis Antibody and Tuberculin Positive Tests Initially Misdiagnosed as Active Tuberculosis in a Broncholithiasis Patient with Recurrent Hemoptysis and Fever Proven by Lung Lobectomy.

Clin Lab 2019 Jan;65(1)

Background: To report a case of broncholithiasis with recurrent hemoptysis and fever initially misdiagnosed as active tuberculosis.

Methods: The chest contrast-enhanced CT scan, electronic bronchoscope, and ultrathin bronchoscope were performed leading to the diagnosis of broncholithiasis, open lung lobectomy was done after thoracic surgery consultation.

Results: The chest contrast-enhanced CT scan showed a high-density intratracheal shadow and calcified lymph nodes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7754/Clin.Lab.2018.180713DOI Listing
January 2019

Anemia Combined Significantly Increased High-Sensitivity C Reactive Protein and Lung Lesions Lead to the Diagnosis of Granulomatosis with Polyangiitis Proven by Lung Biopsy and Anti-neutrophil Cytoplasmic Antibody Test.

Clin Lab 2019 Jan;65(1)

Background: To report an atypical case misdiagnosed as lung abscess over the past 2 months, but persistent anemia combined with significantly increased hs-CRP and lung lesions indicated systemic lesion, which led to the diagnosis of granulomatosis with polyangiitis proven by lung biopsy and anti-neutrophil cytoplasmic antibody test (ANCA).

Methods: The complete blood count, hs-CRP, and anti-neutrophil cytoplasmic antibody (ANCA) test were performed. The pathology consultation for the lung biopsy was arranged. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7754/Clin.Lab.2018.180733DOI Listing
January 2019

High Serum Neuron-Specific Enolase (NSE) Level Firstly Ignored as Normal Reaction in a Small Cell Lung Cancer Patient: a Case Report and Literature Review.

Clin Lab 2019 Jan;65(1)

Background: High serum neuron-specific enolase (NSE) level has been in use as a tumor marker; however, some physicians may ignore NSE levels in serum, especially when the patients are asymptomatic. Here we report a case that a 51 year old female patient with no respiratory symptoms who had a NSE level which increased extremely over three months and was eventually diagnosed small cell lung cancer (SCLC).

Methods: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in right pulmonary hilar enlarged lymph node was performed for diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7754/Clin.Lab.2018.180703DOI Listing
January 2019

Lung cancer family history and exposure to occupational/domestic coal combustion contribute to variations in clinicopathologic features and gene fusion patterns in non-small cell lung cancer.

Thorac Cancer 2019 Feb 18. Epub 2019 Feb 18.

Department of Thoracic Surgery I, The Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital, Yunnan Cancer Center, The International Cooperation Key Laboratory of Regional Tumor in High Altitude Area, Kunming, China.

Background: Both genetic and environmental factors contribute to the development of cancer and its mutant spectrum. Lung cancer has familial aggregation. Lung cancer caused by non-tobacco factors has unique pathological and molecular characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1759-7714.12987DOI Listing
February 2019

Cerebral oxygenation associated with INSURE versus LISA procedures in surfactant-deficient newborn piglet RDS model.

Pediatr Pulmonol 2019 Feb 18. Epub 2019 Feb 18.

Neonatal Intensive Care Unit, Cruces University Hospital, Barakaldo, Bizkaia, Spain.

Background: Nasal continuous-positive airway pressure (nCPAP) with the INSURE (INtubation-SURfactant-Extubation) or LISA (Less-Invasive Surfactant Administration) procedures are increasingly being chosen as the initial treatment for neonates with surfactant deficiency. Our objective was to compare the effects on cerebral oxygenation of different methods for surfactant administration: INSURE and LISA, using a nasogastric tube (NT) or a LISAcath® catheter, in spontaneously breathing SF-deficient newborn piglets.

Methods: Eighteen newborn piglets with SF-deficient lung injury produced by repetitive bronchoalveolar lavages were randomly assigned to INSURE, LISA-NT, or LISAcath® groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24277DOI Listing
February 2019

Chemotherapy combined with Endostar as salvage treatment for EGFR-tyrosine kinase inhibitor primary resistance in an advanced non-small cell lung cancer patient with EGFR L858R mutation and ROS1 fusion: A case report.

Thorac Cancer 2019 Feb 18. Epub 2019 Feb 18.

Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.

EGFR-activating mutations have been recognized as the most important predictor of response to EGFR-tyrosine kinase inhibitors (TKIs); however, 20-30% of patients harboring EGFR-activating mutations show poor responses. The mechanisms of such EGFR-TKI primary resistance are still poorly understood. In our case, a non-small cell lung cancer patient developed intrinsic EGFR-TKI resistance and was then confirmed to simultaneously harbor an L858R mutation and ROS1 rearrangement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1759-7714.13003DOI Listing
February 2019

Primary non-gestational uterine choriocarcinoma mimicking leiomyoma.

Pathol Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Gynecologic Oncology, Kawasaki Medical School, Kurashiki, Okayama, Japan.

Uterine choriocarcinoma is a trophoblastic neoplasm that is most commonly gestational but can also be non-gestational in origin. However, primary non-gestational uterine choriocarcinoma is very rare, with only few cases having been reported. We report a case of a premenopausal woman who had initially been diagnosed with myoma delivery but who was discovered to have primary non-gestational uterine choriocarcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pin.12763DOI Listing
February 2019

A case of lung adenocarcinoma complicated by pulmonary talcosis occurring in a patient employed in the confectionery industry.

Pathol Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology, Gifu University Hospital, Gifu-City, Japan.

A 73-year-old Japanese man, who worked at a confectionery company for more than 20 years, was diagnosed with a 28 mm nodular lesion in the superior lobe of the right lung by whole-body computed tomography examination. A biopsy revealed the presence of adenocarcinoma. With a diagnosis of a primary lung cancer, a right upper lobectomy was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pin.12772DOI Listing
February 2019

Non-malignant respiratory disease among workers in the rubber manufacturing industry: A systematic review and meta-analysis.

Am J Ind Med 2019 Feb 18. Epub 2019 Feb 18.

Respiratory Health Division, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Morgantown, West Virginia.

Background: Non-malignant respiratory disease (NMRD) cases have occurred among rubber manufacturing workers. We examined exposure to rubber manufacturing emissions as a risk factor for NMRD.

Methods: From a systematic literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (strong, intermediate, non-significant positive association, none) between exposure to rubber manufacturing emissions and NMRD-related morbidity and mortality, and conducted two meta-analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajim.22959DOI Listing
February 2019

Late Presentation of Transfusion-related Acute Lung Injury in the Emergency Department.

Clin Pract Cases Emerg Med 2019 Feb 7;3(1):33-35. Epub 2019 Jan 7.

San Antonio Uniformed Services Health Education Consortium, Department of Emergency Medicine, San Antonio, Texas.

Transfusion-related acute lung injury (TRALI) is a complication of blood product transfusion characterized by respiratory distress with bilateral lung infiltrates and non-cardiogenic pulmonary edema developing within six hours of transfusion. TRALI is believed to result from an immunological response to transfused blood products. TRALI is a clinical diagnosis that requires the exclusion of other etiologies of pulmonary edema and acute lung injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5811/cpcem.2018.11.40592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366380PMC
February 2019

Journal Club - Endobronchial Valve Bronchoscopic Lung Volume Reduction.

Authors:
Ron Balkissoon

Chronic Obstr Pulm Dis 2019 Jan 25;6(1):118-125. Epub 2019 Jan 25.

Denver, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15326/jcopdf.6.1.2019.0126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373582PMC
January 2019

Efficacy and Safety of Nebulized Glycopyrrolate/eFlow® Closed System in Patients with Moderate-to-Very-Severe Chronic Obstructive Pulmonary Disease with Pre-Existing Cardiovascular Risk Factors.

Chronic Obstr Pulm Dis 2018 Dec 13;6(1):86-99. Epub 2018 Dec 13.

Sunovion Pharmaceuticals Inc., Marlborough, Massachusetts.

The purpose of this study was to assess the effect of pre-existing cardiovascular (CV) risk factors on the efficacy and safety of nebulized glycopyrrolate (GLY) in patients with chronic obstructive pulmonary disease (COPD). A total of 2379 patients from 3 phase III studies (12-week, placebo-controlled Glycopyrrolate for Obstructive Lung Disease via Electronic Nebulizer [GOLDEN] -3 and -4, and 48-week, active-controlled GOLDEN-5) stratified by high (n=1526) or low (n=853) CV risk were randomized to placebo, GLY 25 mcg or 50 mcg twice daily, or tiotropium (TIO; 18 mcg once daily). Safety, lung function, patient-reported outcomes (PROs), and exacerbations were assessed by CV risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15326/jcopdf.6.1.2018.0146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373592PMC
December 2018

Mortality and Exacerbations by Global Initiative for Chronic Obstructive Lung Disease Groups ABCD: 2011 Versus 2017 in the COPDGene® Cohort.

Chronic Obstr Pulm Dis 2019 Jan 10;6(1):64-73. Epub 2019 Jan 10.

Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor.

The Global initiative for chronic Obstructive Lung Disease (GOLD) ABCD groupings were recently modified. The GOLD 2011 guidelines defined increased risk as forced expiratory volume in 1 second (FEV) < 50% predicted or ≥ 2 outpatient or ≥ 1 hospitalized exacerbation in the prior year, whereas the GOLD 2017 guidelines use only exacerbation history. We compared mortality and exacerbation rates in the Genetic Epidemiology of COPD Study cohort (COPDGene) by 2011 (exacerbation history/FEV and dyspnea) versus 2017 (exacerbations and dyspnea) classifications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15326/jcopdf.6.1.2018.0130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373581PMC
January 2019

Patient Preferences for Endobronchial Valve Treatment of Severe Emphysema.

Chronic Obstr Pulm Dis 2018 Dec 11;6(1):51-63. Epub 2018 Dec 11.

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Patients with severe emphysema have limited treatment options. Little is known about patients' willingness to accept risks for new treatments that offer meaningful benefits. We determined treatment preferences of patients with severe emphysema using a web-based discrete-choice experiment survey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15326/jcopdf.6.1.2018.0147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373586PMC
December 2018

Effect of Lung Volume Reduction Surgery on Respiratory Muscle Strength in Advanced Emphysema.

Chronic Obstr Pulm Dis 2018 Oct 12;6(1):40-50. Epub 2018 Oct 12.

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.

Long-term effects of lung volume reduction surgery (LVRS) on respiratory muscle strength and effects of age, sex, and emphysema pattern on these changes are unknown. Therefore, we aimed to determine the long-term effect of LVRS on respiratory muscle strength changes in severe emphysema. The National Emphysema Treatment Trial was a prospective controlled multicentered trial, comparing LVRS to optimal medical treatment on survival and maximal exercise capacity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15326/jcopdf.6.1.2018.0188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373585PMC
October 2018

Comparing Patients with ZZ Versus SZ Alpha-1 Antitrypsin Deficiency: Findings from AlphaNet's Disease Management Program.

Chronic Obstr Pulm Dis 2018 Nov 30;6(1):29-39. Epub 2018 Nov 30.

Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Health, University of Colorado Denver School of Medicine, Denver.

: The aim of this study was to examine differences in demographic, health, and behavioral characteristics in individuals with ZZ and SZ genotypes of alpha-1 antitrypsin deficiency (AATD) within AlphaNet's Disease Management and Prevention Program (ADMAPP). : Self-reported data from 3535 patients with AATD, including 3031 (85.7%) patients with ZZ, ZNull, and NullNull genotypes (referred to here as ZZ), and 504 (14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15326/jcopdf.6.1.2018.0134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373591PMC
November 2018

Urban-Rural Disparities in Chronic Obstructive Pulmonary Disease Management and Access in Uganda.

Chronic Obstr Pulm Dis 2019 Jan 4;6(1):17-28. Epub 2019 Jan 4.

Department of Medicine and Lung Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Almost 90% of chronic obstructive pulmonary disease (COPD) deaths occur in low- and middle-income countries (LMICs), where there are large rural populations and access to health care for COPD is poor. The purpose of this study was to compare urban-rural provider experiences regarding systemic facilitators and barriers to COPD management and treatment access. We conducted a qualitative study using direct observations and in-depth semi-structured interviews with 16 and 10 health care providers in urban Kampala and rural Nakaseke, Uganda, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15326/jcopdf.6.1.2018.0143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373590PMC
January 2019

Clinical Characteristics and Radiologic Features of Immunocompromised Patients With Pauci-Bacillary Pulmonary Tuberculosis Receiving Delayed Diagnosis and Treatment.

Open Forum Infect Dis 2019 Feb 17;6(2):ofz002. Epub 2019 Jan 17.

Departments of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: Pauci-bacillary pulmonary tuberculosis (TB) can be delayed to diagnose and start anti-TB therapy, especially in immunocompromised patients. We therefore evaluated the clinical and radiologic features of these delayed cases.

Methods: Immunocompromised adult patients with pauci-bacillary pulmonary TB were retrospectively enrolled in a tertiary hospital in an intermediate-TB burden country over a 5-year period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofz002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366656PMC
February 2019

Mineralogy Controlled Dissolution of Uranium from Airborne Dust in Simulated Lung Fluids (SLFs) and Possible Health Implications.

Environ Sci Technol Lett 2019 Feb 5;6(2):62-67. Epub 2018 Dec 5.

Department of Chemistry, New Mexico Tech, 801 Leroy Place, Socorro, New Mexico 87801, United States.

The recent increase in cardiovascular and metabolic disease in the Navajo population residing close to the Grants Mining District (GMD) in New Mexico is suggested to be due to exposure to environmental contaminants, in particular uranium in respirable dusts. However, the chemistry of uranium-containing-dust dissolution in lung fluids and the role of mineralogy are poorly understood, as is their impact on toxic effects. The current study is focused on the dissolution of xcontaining-dust, collected from several sites near Jackpile and St. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.estlett.8b00557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372124PMC
February 2019

Fusobacterium Septicemia with Liver and Lung Abscesses Due to Diverticulitis.

ACG Case Rep J 2018 19;5:e99. Epub 2018 Dec 19.

Department of Internal Medicine, Division of Gastroenterology, Detroit Medical Center/Wayne State University, Detroit, MI.

The species is known for its association with septic thrombophlebitis of the internal jugular vein (Lemierre's syndrome). Lemierre's syndrome is associated with septic emboli to the liver and lungs, often causing multiple abscesses. We present a unique case of septicemia in which the bacteria invaded the portal vein through the gastrointestinal mucosa due to diverticulitis and spread hematogenously to the liver and lungs, causing abscesses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14309/crj.2018.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358581PMC
December 2018

IQOS exposure impairs human airway cell homeostasis: direct comparison with traditional cigarette and e-cigarette.

ERJ Open Res 2019 Feb 11;5(1). Epub 2019 Feb 11.

Medical Sciences, School of Life Sciences, Faculty of Science, University of Technology, Sydney, Australia.

http://ow.ly/wZ5P30ng8bU. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/23120541.00159-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368999PMC
February 2019

European Respiratory Society International Congress, Paris, 2018: highlights from the Clinical Assembly.

ERJ Open Res 2019 Feb 11;5(1). Epub 2019 Feb 11.

Dept of Pneumology and Critical Care Medicine, Thoraxklinik, Heidelberg University Hospital, Heidelberg, Germany.

This article contains highlights and a selection of the scientific advances from the European Respiratory Society's Clinical Assembly (Assembly 1 and its five respective groups) that were presented at the 2018 European Respiratory Society International Congress in Paris, France. The most relevant topics from each of the groups will be discussed, covering a wide range of areas including clinical problems, rehabilitation and chronic care, thoracic imaging, interventional pulmonology, and general practice and primary care. The newest research, actual data and highlight sessions will be discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/23120541.00176-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368995PMC
February 2019

Pulmonary veno-occlusive disease is highly prevalent in scleroderma patients undergoing lung transplantation.

ERJ Open Res 2019 Feb 11;5(1). Epub 2019 Feb 11.

Division of Pulmonary Medicine, Dept of Medicine, National Jewish Health, Denver, CO, USA.

http://ow.ly/vPvc30neJZV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/23120541.00168-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368993PMC
February 2019

Mandibular blastomycosis: A case report and review of the literature.

Germs 2018 Dec 3;8(4):207-213. Epub 2018 Dec 3.

BDS, MB ChB, FRCS, FACS, Division of Oral and Maxillofacial Surgery, Loyola University Medical Center, 2160 S. 1st Ave., Maywood, IL 60153, USA.

Introduction: Blastomycosis is an endemic mycosis in the United States known to primarily cause pneumonia. However, dissemination to different organs including the musculoskeletal system has been described.

Case Report: We report a case of mandibular blastomycosis in a healthy patient with no evidence of lung involvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18683/germs.2018.1148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363401PMC
December 2018

Pulmonary histoplasmoma: a disguised malady.

Autops Case Rep 2018 Oct-Dec;8(4):e2018065. Epub 2018 Dec 5.

Universidade de São Paulo, School of Medicine, Department of Surgery. São Paulo, SP, Brazil.

Histoplasmosis is a mycosis caused by the dimorphic fungus, , which is transmitted via dust and aerosols. Lung involvement is the most common, with a varied clinical presentation. Although it is not the only source of infection, is frequently found in bat guano, which is the reason why it is highly prevalent among caving practitioners. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4322/acr.2018.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360832PMC
December 2018
  • Page 1 of 16991