53,656 results match your criteria Lung Transplantation


Impact of gastroesophageal reflux disease on idiopathic pulmonary fibrosis and lung transplant recipients.

Curr Opin Gastroenterol 2022 Jul;38(4):411-416

Advanced Lung Disease Specialists, Baylor University Medical Center, Dallas, Texas, USA.

Purpose Of Review: Idiopathic pulmonary fibrosis (IPF) is a prevalent subset of interstitial lung disease (ILD) that often progresses to require lung transplantation. Gastroesophageal reflux disease (GERD) is common in the IPF population, and GER-related micro-aspiration appears to be an important risk factor for IPF pathogenesis and for the deterioration of transplanted lung function.

Recent Findings: Many patients with IPF have elevated esophageal acid exposure on reflux testing despite having no or minimal symptoms. Read More

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Can we HALT obesity following lung transplant? A Dietitian- and Physiotherapy-directed pilot intervention.

Clin Transplant 2022 Jun 27:e14763. Epub 2022 Jun 27.

Nutrition Department, The Alfred Hospital, Melbourne, Victoria, Australia.

Introduction: Unintentional weight gain, overweight and obesity following solid organ transplantation (SOT) are well-established and linked to morbidity and mortality risk factors. No interventional studies aimed at prevention have been undertaken among lung transplant (LTx) recipients. The combination of group education and telephone coaching is effective in the general population but is untested among SOT cohorts. Read More

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Immune-Checkpoint Expression on CD4, CD8 and NK Cells in Blood, Bronchoalveolar Lavage and Lymph Nodes of Sarcoidosis.

Mol Diagn Ther 2022 Jun 27. Epub 2022 Jun 27.

Respiratory Diseases and Lung Transplantation Unit, Department of Medical and Surgical Sciences & Neurosciences, Siena University Hospital, Viale Bracci 1, 53100, Siena, Italy.

Background: Sarcoidosis features non-necrotizing granulomas consisting mainly of activated CD4-lymphocytes. T-cell activation is regulated by immune checkpoint (IC) molecules. The present study aimed to compare IC expression on CD4, CD8 and NK cells from peripheral, alveolar and lung-draining lymph node (LLN) samples of sarcoidosis patients. Read More

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FIRST BILATERAL LUNG TRANSPLANTATION VIA ANTEROLATERAL THORACOTOMY IN UKRAINE.

Wiad Lek 2022 ;75(5 pt 2):1403-1407

LVIV TERRITORIAL MEDICAL GROUP "MULTIDISCIPLINARY CLINICAL HOSPITAL OF INTENSIVE CARE AND EMERGENCY", LVIV, UKRAINE.

Objective: The aim: The aim of this work is to describe the clinical case of the first lung transplant in Ukraine through anterolateral access and to analyze management of patient in the postoperative period, followed by assessment of his general condition and quality of life.

Patients And Methods: Materials and methods: Analysis of the clinical case of the patient who underwent the first lung transplantation in Ukraine, including a description of surgery, anesthesia, and postoperative recovery.

Conclusion: Conclusions: Thus, based on the data of the world literature, as well as on the results of treatment on the basis of Municipal Non-Profit Enterprise " Lviv Emergency Clinical Hospital" we can conclude that lung transplantation is one of the most effective methods of treatment of patients with end-stage lung disease. Read More

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Non-pulmonary complications after lung transplantation: part II.

Indian J Thorac Cardiovasc Surg 2022 Jul 12;38(Suppl 2):290-299. Epub 2021 Oct 12.

Lung Transplant Program, University of Texas Southwestern Medical Center, 5939 Harry Hines Blvd. Suite 603, Dallas, TX 75235-8550 USA.

Lung transplantation (LT) is a viable therapeutic option in the treatment of advanced lung disease. With improvements in post-transplant survival, complications involving different organ systems after LT are increasingly seen. While non-infectious, extrapulmonary complications after LT are not frequently responsible for early post-transplant mortality, they significantly impact the quality of life and long-term survival. Read More

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Chronic lung allograft dysfunction.

Indian J Thorac Cardiovasc Surg 2022 Jul 16;38(Suppl 2):318-325. Epub 2021 Nov 16.

Baylor College of Medicine, 6720 Bertner Ave, Houston, TX 77030 USA.

Lung transplantation remains the only cure for selected patients with advanced irreversible lung diseases. More than 4000 lung transplants are performed worldwide annually. In the last two decades, significant advances have been made in this arena, the most impactful being a modest but improved survival of the recipients. Read More

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Multidisciplinary collaboration: the key to advancing lung transplantation outcomes.

Indian J Thorac Cardiovasc Surg 2022 Jul 29;38(Suppl 2):209-210. Epub 2021 Apr 29.

Division of Cardiovascular and Thoracic Anesthesiology, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN USA.

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Airway complications following lung transplantation.

Indian J Thorac Cardiovasc Surg 2022 Jul 1;38(Suppl 2):326-334. Epub 2022 Jun 1.

Lerner College of Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195 USA.

Airway complications post lung transplant account for significant morbidity (between 2 and 18%) and mortality (2 to 4%). The commonly encountered airway complications include necrosis and dehiscence, exophytic granulation tissue, bronchial stenosis, tracheo-broncho-malacia, bronchial fistulae, and airway infections. With growing experience in surveillance bronchoscopy post lung transplant and availability of advanced endobronchial interventional therapies, better management of lung transplant recipients is now possible. Read More

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Hyperammonemia in lung transplant patients and its management: a review.

Indian J Thorac Cardiovasc Surg 2022 Jul 14;38(Suppl 2):335-346. Epub 2022 Mar 14.

Division of Cardiothoracic Surgery, University of Kentucky, Lexington, KY USA.

Objective: To synthesize the evidence for incidence, pathophysiology, etiology, and protocol-based management of hyperammonemia in lung transplant patients.

Background: Elevated ammonia levels are toxic to the brain, and hyperammonemia results in a potentially fatal complication for lung transplant recipients. The hallmark of this condition is ammonia production being way out of proportion to the degree of liver derangement. Read More

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Non-pulmonary complications after lung transplantation: Part I.

Indian J Thorac Cardiovasc Surg 2022 Jul 8;38(Suppl 2):280-289. Epub 2021 Oct 8.

Lung Transplant Program, University of Texas Southwestern Medical Center, 5939 Harry Hines Blvd. Suite 603, Dallas, TX 75235-8550 USA.

Lung transplantation (LT) is a viable therapeutic option in the treatment of advanced lung disease. With improvements in post-transplant survival, complications involving different organ systems after LT are increasingly seen. While non-infectious, extrapulmonary complications after LT are not frequently responsible for early post-transplant mortality, they significantly impact the quality of life and long-term survival. Read More

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Induction and maintenance immunosuppression in lung transplantation.

Indian J Thorac Cardiovasc Surg 2022 Jul 17;38(Suppl 2):300-317. Epub 2021 Sep 17.

Department of Pulmonary, Critical Care of Sleep, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198-5910 USA.

Immunosuppression for lung transplant recipients is a critical part of post-transplant care, to prevent acute and chronic rejection. Treatment protocols consist of induction and maintenance immunotherapy. Induction agents provide an immediate state of immunosuppression following transplantation and over time, and their use has become more commonplace. Read More

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The art of lung transplantation-lessons learnt from one thousand lung transplants.

Indian J Thorac Cardiovasc Surg 2022 Jul 23;38(Suppl 2):207-208. Epub 2022 Jan 23.

Department of Thoracic Medicine and Surgery, Temple University, 3401 N Broad Street, Philadelphia, PA 19140 USA.

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Immunological considerations-HLA matching and management of high immunological risk recipients.

Indian J Thorac Cardiovasc Surg 2022 Jul 29;38(Suppl 2):248-259. Epub 2021 Jul 29.

Department of Thoracic Medicine, Temple University Hospital, Philadelphia, USA.

Lung transplant outcomes remain inferior largely due to mismatching in human leukocyte antigens (HLAs) that leads to chronic rejection and chronic allograft dysfunction. The mismatched donor HLAs can be recognized by the effector T cells or donor-specific HLA antibodies. This review summarizes mechanisms leading to immune responses as a result of HLA mismatching. Read More

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Indications, Complications, and Outcomes of Cardiac Surgery After Heart Transplantation: Results From the Cash Study.

Front Cardiovasc Med 2022 9;10:879612. Epub 2022 Jun 9.

Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.

Background: Allograft pathologies, such as valvular, coronary artery, or aortic disease, may occur early and late after cardiac transplantation. Cardiac surgery after heart transplantation (CASH) may be an option to improve quality of life and allograft function and prolong survival. Experience with CASH, however, has been limited to single-center reports. Read More

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Caught in a vice.

Indian J Thorac Cardiovasc Surg 2022 Jul 7;38(4):438-441. Epub 2022 Apr 7.

Temple University Hospital 3401 N Broad St Philadelphia, Philadelphia, PA 19140 USA.

Esophageal dysmotility and dysphagia are well known in patients with scleroderma. Interstitial lung disease (ILD) in these patients is an indication for lung transplantation but is considered high risk in many centers. This report is an attempt to highlight how anatomical causes can contribute to dysphagia in such patients and complicate the post-operative course after lung transplantation. Read More

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Validation of a Simple, Rapid, and Cost-Effective Method for Acute Rejection Monitoring in Lung Transplant Recipients.

Transpl Int 2022 9;35:10546. Epub 2022 Jun 9.

Department of Medical Sciences, University of Turin, Turin, Italy.

Despite advances in immunosuppression therapy, acute rejection remains the leading cause of graft dysfunction in lung transplant recipients. Donor-derived cell-free DNA is increasingly being considered as a valuable biomarker of acute rejection in several solid organ transplants. We present a technically improved molecular method based on digital PCR that targets the mismatch between the recipient and donor at the locus. Read More

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Characterization of the PF-ILD phenotype in patients with advanced pulmonary sarcoidosis.

Respir Res 2022 Jun 25;23(1):169. Epub 2022 Jun 25.

Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.

Background: Advanced pulmonary sarcoidosis causes significant morbidity and can lead to death. Large trials demonstrated efficacy of antifibrotics in patients with progressive fibrosing interstitial lung diseases (PF-ILD), including a few with sarcoidosis. To date, little is known about this progressive fibrosing phenotype in sarcoidosis. Read More

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[French practical guidelines for the diagnosis and management of IPF - 2021 update, full version].

Rev Mal Respir 2022 Jun 22. Epub 2022 Jun 22.

Service d'anatomie-pathologique, groupement hospitalier est, HCL, Bron, France.

Background: Since the previous French guidelines were published in 2017, substantial additional knowledge about idiopathic pulmonary fibrosis has accumulated.

Methods: Under the auspices of the French-speaking Learned Society of Pulmonology and at the initiative of the coordinating reference center, practical guidelines for treatment of rare pulmonary diseases have been established. They were elaborated by groups of writers, reviewers and coordinators with the help of the OrphaLung network, as well as pulmonologists with varying practice modalities, radiologists, pathologists, a general practitioner, a head nurse, and a patients' association. Read More

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Development and validation of a deep learning model to predict the survival of patients in ICU.

J Am Med Inform Assoc 2022 Jun 25. Epub 2022 Jun 25.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Patients in the intensive care unit (ICU) are often in critical condition and have a high mortality rate. Accurately predicting the survival probability of ICU patients is beneficial to timely care and prioritizing medical resources to improve the overall patient population survival. Models developed by deep learning (DL) algorithms show good performance on many models. Read More

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Low-intensity immunosuppressive therapy for chronic graft-versus-host disease.

Transplant Cell Ther 2022 Jun 22. Epub 2022 Jun 22.

Division of Hematology, Jichi Medical University Saitama Medical Center. Electronic address:

In general, an initial systemic treatment for chronic graft-versus-host disease (cGVHD) is 0.5 to 1 mg/kg of prednisolone (PSL). However, patients without high-risk features are sometimes treated with calcineurin inhibitors (CI) or PSL at lower doses. Read More

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New-onset Obesity After Lung Transplantation: Incidence, Risk Factors, and Clinical Outcomes.

Transplantation 2022 Jun 24. Epub 2022 Jun 24.

Department of Nutrition, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada.

Background: Lung transplant (LTx) recipients who gain weight after transplantation may experience an upward shift in body mass index (BMI) that places them in the obese category. The incidence, risk factors, and impact on metabolic health and mortality of new-onset obesity have not been documented in the LTx setting.

Methods: This single-center retrospective study included 564 LTx recipients. Read More

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Updated Views on Neutrophil Responses in Ischemia-Reperfusion Injury.

Transplantation 2022 Jun 24. Epub 2022 Jun 24.

Department of Surgery, Washington University School of Medicine, Saint Louis, MO.

Ischemia-reperfusion injury is an inevitable event during organ transplantation and represents a primary risk factor for the development of early graft dysfunction in lung, heart, liver, and kidney transplant recipients. Recent studies have implicated recipient neutrophils as key mediators of this process and also have found that early innate immune responses after transplantation can ultimately augment adaptive alloimmunity and affect late graft outcomes. Here, we discuss signaling pathways involved in neutrophil recruitment and activation after ischemia-mediated graft injury in solid organ transplantation with an emphasis on lung allografts, which have been the focus of recent studies. Read More

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[Two Cases of Robot-Assisted Total Pelvic Exenteration and Intracorporeal Ileal Conduit forLocally Advanced Rectal Cancer].

Hinyokika Kiyo 2022 May;68(5):155-159

The Department of Digestive Surgery and Transplantation, Tokushima University Graduate School of Biomedical Sciences.

We describe two cases of locally advanced rectal cancer (LARC) treated with robot-assisted total pelvic exenteration (Ra-TPE) and intracorporeal ileal conduit (ICIC). The first case was in a 71-year-old man with LARC (RbP, T4bN2bM0, cStage IIIc). He was started on bevacizumab+S-1/oxaliplatin therapy in July 2019. Read More

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Limitations of Arterial Partial Pressure of Oxygen to Fraction of Inspired Oxygen Ratio for the Evaluation of Donor Lung Function.

Artif Organs 2022 Jun 23. Epub 2022 Jun 23.

Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.

Background: Evaluation of donor lung function relies on the arterial oxygen partial pressure to inspired oxygen fraction ratio (PaO /FiO ) measurement. Hemodynamic, metabolic derangements, and therapeutic intervention occurring during brain dead observation may influence the evaluation of gas exchange.

Methods: We performed a mathematical analysis to explore the influence of the extrapulmonary determinants on the interpretation of PaO /FiO in the brain-dead donor and during Ex-Vivo Lung Perfusion (EVLP). Read More

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Transbronchial Cryobiopsy Compared to Forceps Biopsy for Diagnosis of Acute Cellular Rejection in Lung Transplants: Analysis of 63 Consecutive Procedures.

Life (Basel) 2022 Jun 15;12(6). Epub 2022 Jun 15.

Department of Pulmonology, Center of Lung Transplantation, Center of Adult Cystic Fibrosis, Interventional Lung Center, University Hospital Zurich, 8091 Zurich, Switzerland.

Background: Acute cellular rejection (ACR) is a complication after lung transplantation (LTx). The diagnosis of ACR is based on histologic findings using transbronchial forceps biopsy (FB). However, its diagnostic accuracy is limited because of the small biopsy size and crush artifacts. Read More

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How COVID-19 Affects Lung Transplantation: A Comprehensive Review.

J Clin Med 2022 Jun 18;11(12). Epub 2022 Jun 18.

Department of Immunology, Second Faculty of Medicine, Charles University, University Hospital Motol, 150 06 Prague, Czech Republic.

Lung transplant (LuTx) recipients are at a higher risk of developing serious illnesses from COVID-19, and thus, we have closely reviewed the consequences of the COVID-19 pandemic on lung transplantation. In most transplant centers, the overall LuTx activity significantly declined and led to a specific period of restricting lung transplantation to urgent cases. Moreover, several transplant centers reported difficulties due to the shortage of ICU capacities. Read More

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Intratracheal Transplantation of Mesenchymal Stem Cells Attenuates Hyperoxia-Induced Microbial Dysbiosis in the Lungs, Brain, and Gut in Newborn Rats.

Int J Mol Sci 2022 Jun 13;23(12). Epub 2022 Jun 13.

Department of Pediatrics, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.

We attempted to determine whether intratracheal (IT) transplantation of mesenchymal stem cells (MSCs) could simultaneously attenuate hyperoxia-induced lung injuries and microbial dysbiosis of the lungs, brain, and gut in newborn rats. Newborn rats were exposed to hyperoxia (90% oxygen) for 14 days. Human umbilical cord blood-derived MSCs (5 × 10) were transplanted via the IT route on postnatal day (P) five. Read More

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Application of Place-Based Methods to Lung Transplant Medicine.

Int J Environ Res Public Health 2022 Jun 15;19(12). Epub 2022 Jun 15.

GIS Health & Hazards Lab, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Lung transplantation is an increasingly common lifesaving therapy for patients with fatal lung diseases, but this intervention has a critical limitation as median survival after LT is merely 5.5 years. Despite the profound impact of place-based factors on lung health, this has not been rigorously investigated in LT recipients-a vulnerable population due to the lifelong need for daily life-sustaining immunosuppression medications. Read More

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Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress.

J Immunother Cancer 2022 Jun;10(6)

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

Background: Adoptive cell therapy using cytotoxic lymphocytes is an efficient immunotherapy against solid and hematological cancers. However, elevated levels of reactive oxygen species (ROS) in the hostile tumor microenvironment can impair NK cell and T cell function. Auranofin, a gold (I)-containing phosphine compound, is a strong activator of the transcription factor Nrf2. Read More

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Heart-Lung Transplantation - technical modifications to simplify the procedure.

Ann Thorac Surg 2022 Jun 20. Epub 2022 Jun 20.

Department of Cardiothoracic Surgery, The Alfred Hospital, Melbourne, Australia.

Heart-lung transplantation is a mature therapy but has perioperative complications such as phrenic nerve dysfunction and mediastinal bleeding. We report our technical modifications to simplify the procedure. Read More

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