44,717 results match your criteria Lung Transplantation


Outcome of inter-hospital transfer of patients on extracorporeal membrane oxygenation in Switzerland.

Swiss Med Wkly 2019 Apr 17;149:w20054. Epub 2019 Apr 17.

Clinic for Cardiovascular Surgery, University Heart Centre, Zurich, Switzerland.

Aims Of The Study: An extracorporeal membrane oxygenation system (ECMO), as a bridge to either recovery, a ventricular assist device (VAD), or heart or lung transplantation, may be the only lifesaving option for critically ill patients suffering from refractory cardiac, respiratory or combined cardiopulmonary failure. As peripheral hospitals may not offer ECMO treatment, tertiary care centres provide specialised ECMO teams for on-site implantation and subsequent patient transfer on ECMO to the tertiary hospital. This study reports the results of the largest ECMO transportation programme in Switzerland and describes its feasibility and safety. Read More

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http://dx.doi.org/10.4414/smw.2019.20054DOI Listing

Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

N Engl J Med 2019 04;380(16):1525-1534

From the Departments of Bone Marrow Transplantation and Cellular Therapy (E.M., B.T., W.J., S.G.), Hematology (S.Z., Z.M., J.C., J.D., X.T., B.Y.R., M.J.W., B.P.S.), Therapeutics Production and Quality (T.L., M.M.M.), Immunology (H.A., B.Y.), Pharmaceutical Sciences (S.J.C.), Biostatistics (G.K., C.L.), and Infectious Diseases (G.M.), St. Jude Children's Research Hospital, Memphis, TN; the Allergy and Clinical Immunology Division, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru (J.C.A.B.); the Department of Pediatrics, Allergy-Immunology Division, Children's Hospital Los Angeles, Los Angeles (J.A.C.), and the Department of Pediatrics, Division of Pediatric Allergy-Immunology-Bone Marrow Transplantation, University of California, San Francisco (UCSF) Benioff Children's Hospital, San Francisco (J.R.L.-B., J.M.P., M.J.C.) - both in California; the Department of Pediatrics, Pediatric Allergy and Immunology, University of New Mexico, Albuquerque (E.D.); University of Oklahoma Health Sciences Center, Tulsa (J.T.L.); Departamento de Pediatria da Universidade de Taubaté, Conselho Nacional de Medicina, São Paulo (A.C.M.A.); Copperfield Childcare, Claremont, South Africa (H.W.); and the Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (S.S.D.R., H.L.M.).

Background: Allogeneic hematopoietic stem-cell transplantation for X-linked severe combined immunodeficiency (SCID-X1) often fails to reconstitute immunity associated with T cells, B cells, and natural killer (NK) cells when matched sibling donors are unavailable unless high-dose chemotherapy is given. In previous studies, autologous gene therapy with γ-retroviral vectors failed to reconstitute B-cell and NK-cell immunity and was complicated by vector-related leukemia.

Methods: We performed a dual-center, phase 1-2 safety and efficacy study of a lentiviral vector to transfer complementary DNA to bone marrow stem cells after low-exposure, targeted busulfan conditioning in eight infants with newly diagnosed SCID-X1. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1815408
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http://dx.doi.org/10.1056/NEJMoa1815408DOI Listing
April 2019
4 Reads

Leveraging Single-Cell RNA Sequencing Experiments to Model Intratumor Heterogeneity.

JCO Clin Cancer Inform 2019 Apr;3:1-10

1 All authors: Moffitt Cancer Center and Research Institute, Tampa, FL.

Purpose: Many cancers can be treated with targeted therapy. Almost inevitably, tumors develop resistance to targeted therapy, either from pre-existence or by evolving new genotypes and traits. Intratumor heterogeneity serves as a reservoir for resistance, which often occurs as a result of the selection of minor cellular subclones. Read More

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http://dx.doi.org/10.1200/CCI.18.00074DOI Listing

Better therapeutic potential of bone marrow-derived mesenchymal stem cells compared with chorionic villi-derived mesenchymal stem cells in airway injury model.

Regen Med 2019 Mar 27;14(3):165-177. Epub 2019 Feb 27.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

To determine the efficiency of mesenchymal stem cells (MSCs) of different sources on airway epithelial cells regeneration and track where and to what extent transplanted MSCs home to injured tissues. We performed DiO-labeled human bone marrow-derived MSCs (hBMSCs) or human chorionic villi-derived MSCs transplantation studies using naphthalene-induced airway injury animal models. Compared with human chorionic villi-derived MSCs, hBMSCs facilitated airway epithelium regeneration faster and better from day 5 after transplantation; moreover, more transplanted hBMSCs distributed in injured lung tissues at the early stage of postinjury, which was mediated by C-X-C motif chemokine ligand 12. Read More

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http://dx.doi.org/10.2217/rme-2018-0152DOI Listing

Early clear cell "sugar" lung cancer management: A case report and a brief literature review.

Thorac Cancer 2019 Apr 16. Epub 2019 Apr 16.

UOC of Oncology, University of Rome, Aprilia, Italy.

A clear cell tumor is a histological entity that rarely originates outside of the kidney. We describe a rare case of a clear cell tumor of the lung, also known as "sugar cancer," that occurred in a 74 year-old male patient, and perform a brief literature review. This report highlights the importance of an adequate disease management team, including surgeons, oncologists, and pathologists, to identify the best therapeutic approach to improve survival rates and the quality of life of patients affected by this rare disease. Read More

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http://dx.doi.org/10.1111/1759-7714.13077DOI Listing

Impact of SLCO1B3 polymorphisms on clinical outcomes in lung allograft recipients receiving mycophenolic acid.

Pharmacogenomics J 2019 Apr 17. Epub 2019 Apr 17.

Division of Cardiothoracic Surgery, Department of Surgery, Washington University in Saint Louis, Saint Louis, MO, USA.

Single-nucleotide polymorphisms (SNPs) in genes involved in mycophenolic acid (MPA) metabolism have been shown to contribute to variable MPA exposure, but their clinical effects are unclear. We aimed to determine if SNPs in key genes in MPA metabolism affect outcomes after lung transplantation. We performed a retrospective cohort study of 275 lung transplant recipients, 228 receiving mycophenolic acid and a control group of 47 receiving azathioprine. Read More

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http://dx.doi.org/10.1038/s41397-019-0086-0DOI Listing

The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish.

Development 2019 Apr 16. Epub 2019 Apr 16.

Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany

Tissue morphogenesis requires changes in cell-cell adhesion as well as in cell shape and polarity. Cardiac trabeculation is a morphogenetic process essential to form a functional ventricular wall. Here we show that zebrafish hearts lacking Crb2a, a component of the Crumbs polarity complex, display compact wall integrity defects and fail to form trabeculae. Read More

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http://dx.doi.org/10.1242/dev.171207DOI Listing

An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants.

JCI Insight 2019 Apr 16;5. Epub 2019 Apr 16.

Obliterative bronchiolitis (OB) is a poorly understood airway disease characterized by the generation of fibrotic bronchiolar occlusions. In the lung transplant setting, OB is a pathological manifestation of bronchiolitis obliterans syndrome (BOS), which is a major impediment to long-term recipient survival. Club cells play a key role in bronchiolar epithelial repair, but whether they promote lung transplant tolerance through preventing OB remains unclear. Read More

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http://dx.doi.org/10.1172/jci.insight.124732DOI Listing
April 2019
2 Reads

[The first 25 years of lung transplantations in Denmark].

Ugeskr Laeger 2019 Apr;181(15)

Lung transplantation (LTx) has been performed in Denmark since 1992, and chronic obstructive pulmonary disease and interstitial lung diseases are the major indications. All candidates are subject to an intensive evaluation before being accepted for LTx. Follow-up after transplantation is life-long and includes immunosuppressive medication with a high risk of side effects. Read More

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April 2019
1 Read

Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology.

Eur J Heart Fail 2019 Apr 16. Epub 2019 Apr 16.

Berlin-Brandenburg Center for Regenerative Therapies, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) Berlin, Department of Cardiology, Campus Virchow Klinikum, Charite - Universitaetsmedizin Berlin, Berlin, Germany.

Cardiomyopathies are a heterogeneous group of heart muscle diseases and an important cause of heart failure (HF). Current knowledge on incidence, pathophysiology and natural history of HF in cardiomyopathies is limited, and distinct features of their therapeutic responses have not been systematically addressed. Therefore, this position paper focuses on epidemiology, pathophysiology, natural history and latest developments in treatment of HF in patients with dilated (DCM), hypertrophic (HCM) and restrictive (RCM) cardiomyopathies. Read More

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http://dx.doi.org/10.1002/ejhf.1461DOI Listing
April 2019
6.526 Impact Factor

Trends and hospital outcomes of lung transplantation among patients with and without chronic obstructive pulmonary disease in Spain: a national population-based study (2001-2015).

Int J Chron Obstruct Pulmon Dis 2019 27;14:729-737. Epub 2019 Mar 27.

Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Rey Juan Carlos University, Alcorcón, Madrid, Spain,

Purpose: To describe trends from 2001 to 2015 in incidence and in-hospital outcomes of patients suffering or not suffering from COPD who had undergone lung transplantation (LTx) in Spain.

Methods: We used the Spanish National Hospital Discharge Database to select all admissions for LTx. Incidence was estimated overall and according to the presence of COPD. Read More

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http://dx.doi.org/10.2147/COPD.S189010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443219PMC

Question 13: Can we predict the need for lung transplantation in children with cystic fibrosis?

Paediatr Respir Rev 2019 Feb 19. Epub 2019 Feb 19.

Discipline of Child & Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW 2145, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.prrv.2019.02.002DOI Listing
February 2019

Accelerated Silicosis-An Emerging Epidemic Associated with Engineered Stone. Comment on Leso, V. et al. Artificial Stone Associated Silicosis: A Systematic Review. 2019, (4), 568, doi:10.3390/ijerph16040568.

Authors:
Graeme Edwards

Int J Environ Res Public Health 2019 Apr 2;16(7). Epub 2019 Apr 2.

The Work Doctor, Gold Coast, QLD 4214 Queensland, Australia.

The systematic review by Leso et al. (16 February 2019) is a timely contribution to the body of knowledge concerning silicosis. It highlights the lack of quality data necessary to inform both occupational health risk management and the clinical management of workers exposed to respirable crystalline silica. Read More

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http://dx.doi.org/10.3390/ijerph16071179DOI Listing

Eltrombopag Promotes DNA Repair in Human Hematopoietic Stem and Progenitor Cells.

Exp Hematol 2019 Apr 12. Epub 2019 Apr 12.

National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NH), Bethesda, MD 20892, USA. Electronic address:

A causal link between hematopoietic stem/progenitor cell (HSPC) dysfunction and DNA damage accrual has been proposed. Clinically relevant strategies to maintain genome integrity in these cells are needed. Here we report that eltrombopag, a small molecule agonist of the thrombopoietin (TPO) receptor used in the clinic, promotes DNA double strand break (DSB) repair in human HSPCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X193013
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http://dx.doi.org/10.1016/j.exphem.2019.03.002DOI Listing
April 2019
1 Read

Staphylococcal driveline infections are the predominant type of left ventricular assist device associated infections in Singapore.

Infect Dis (Lond) 2019 Apr 15:1-8. Epub 2019 Apr 15.

a Department of Infectious Diseases , Singapore General Hospital , Singapore.

Background: Left ventricular assist device (LVAD) associated infections (LVADIs) have substantial morbidity and mortality. We aim to describe the incidence and epidemiology of LVADIs in an Asian cohort. This is currently not well studied. Read More

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http://dx.doi.org/10.1080/23744235.2019.1592216DOI Listing

A Novel Mutation in Chronic Granulomatous Disease: Treating the Family, Not Just the Patient.

Front Pediatr 2019 28;7:107. Epub 2019 Mar 28.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Penn State Milton S. Hershey Medical Center, Hershey, PA, United States.

Chronic Granulomatous Disease (CGD) is caused by genetic defects in the phagocyte NADPH oxidase leading to potentially severe infections with catalase positive micro-organisms. With the innate immune system being affected this disease usually presents before the age of 5 years with infections involving the skin, lung, liver or lymphnodes. Infections with specific catalase positive organisms, especially and prompt a workup for CGD in affected patients. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00107/
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http://dx.doi.org/10.3389/fped.2019.00107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447646PMC
March 2019
2 Reads

Risk Factors for Developing Nonmelanoma Skin Cancer after Lung Transplantation.

J Skin Cancer 2019 10;2019:7089482. Epub 2019 Mar 10.

Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Background: Nonmelanoma skin cancer (NSMC) is the most common malignancy after organ transplantation. Lung transplant recipients (LTRs) are particularly prone to develop NMSC as compared to renal or hepatic transplant recipients due to higher dosages of immunosuppression needed. Everolimus, an immunosuppressant used in organ transplant recipients, is thought to inherit a lower risk for NMSC than calcineurin inhibitors, especially in renal transplant recipients. Read More

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http://dx.doi.org/10.1155/2019/7089482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431522PMC
March 2019
2 Reads

A 1-Month Physical Therapy-Based Outpatient Program for Adults Awaiting Lung Transplantation: A Retrospective Analysis of Exercise Capacity, Symptoms, and Quality of Life.

Cardiopulm Phys Ther J 2019 Apr;30(2):61-69

Duke University School of Medicine, Departments of Orthopaedic Surgery, Medicine, Cell Biology.

Purpose: Rehabilitation can improve health outcomes in candidates for lung transplantation. The purpose of this study was to retrospectively evaluate the effect of a one-month physical therapy (PT)-based outpatient program on exercise capacity, symptoms, quality of life and examine predictors of functional outcome changes in adults awaiting lung transplantation.

Methods: Participants (n=141) completed a 23-session exercise and educational program over one month. Read More

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http://dx.doi.org/10.1097/CPT.0000000000000087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456901PMC

Left ventricular lusitropy and primary graft dysfunction in lung transplantation.

J Heart Lung Transplant 2019 Apr 4. Epub 2019 Apr 4.

Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.healun.2019.03.013DOI Listing

Torque-Teno virus viral load as a potential endogenous marker of immune function in solid organ transplantation.

Transplant Rev (Orlando) 2019 Apr 4. Epub 2019 Apr 4.

Viro-immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Solid organ transplantation (SOT) recipients receive immunosuppressive therapy to avoid rejection of the transplanted organ. Immunosuppressive therapy increases the risk of infections. However, no existing marker reliably reveals the status of the immune function in SOT recipients. Read More

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http://dx.doi.org/10.1016/j.trre.2019.03.004DOI Listing

Angiotensin II type I receptor antibodies in thoracic transplantation.

Hum Immunol 2019 Apr 10. Epub 2019 Apr 10.

HLA and Immunogenetics Laboratory, Comprehensive Transplant Center, Cedars-Sinai Health System, Los Angeles, CA, United States.

Angiotensin II type I receptor (AT1R) is a critical player in regulating vasoconstriction, blood pressure, sodium retention. Even though AT1R has limited polymorphism, AT1R antibodies have been detected in several diseases. The role of AT1R antibodies in transplantation is first reported in kidney transplant, and then identified in heart and lung transplants. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.04.007DOI Listing

Risk Analysis of Perioperative Death in Lung Transplant Patients With Severe Idiopathic Pulmonary Hypertension.

Transplant Proc 2019 Apr 8;51(3):875-879. Epub 2019 Jan 8.

Department of Lung Transplantation, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, China. Electronic address:

Objective: To investigate the risk factors for perioperative mortality in patients with severe idiopathic pulmonary hypertension (IPAH) undergoing lung transplantation (LTx).

Methods: Twenty-two IPAH patients were included in the study and were divided 2 groups: a case group with early death post LTx (n = 5, 22.7%) and the remaining 17 recipients (87. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.024DOI Listing

Heart Transplantation in Systemic Sclerosis: New Impulses for Conventional Scleroderma Transplantation Regimen and Scleroderma Diagnostic Monitoring: 2 Case Reports.

Transplant Proc 2019 Apr 9;51(3):865-870. Epub 2019 Jan 9.

Institute for Laboratory and Transfusion Medicine, Herz- und Diabeteszentrum Nordrhein-Westfalen, Ruhr University Bochum, Bad Oeynhausen, Germany.

Background: Although low (but increasing) rates of lung/lung-heart transplantations of scleroderma (systemic sclerosis [SSc]) patients have been reported, exclusive heart transplantation is a rare approach for treatment of heart failure due to SSc.

Cases: We report on 2 cases of SSc patients receiving a heart transplantation (HTx) due to severe and progressive right heart failure without pulmonary artery hypertension. One patient received a hepatitis C virus (HCV)-positive donor heart and recovered excellently from viral transmission after administration of a direct-acting antiviral (DAA) regimen. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.025DOI Listing

Right ventricular mitochondrial respiratory function in a piglet model of chronic pulmonary hypertension.

J Thorac Cardiovasc Surg 2019 Mar 15. Epub 2019 Mar 15.

Research and Innovation Unit, INSERM U999, DHU TORINO, Paris Sud University, Marie Lannelongue Hospital, Le Plessis Robinson, France; Department of Thoracic and Vascular Surgery and Heart-lung Transplantation, Marie Lannelongue Hospital, Le Plessis Robinson, France.

Objective: We aimed to assess the mitochondrial respiratory capacities in the right ventricle in the setting of ventricular remodeling induced by pressure overload.

Methods: Chronic thromboembolic pulmonary hypertension was induced in 8 piglets over a 12-week period (chronic thromboembolic pulmonary hypertension model). Right ventricular remodeling, right ventricular function, and mitochondrial respiratory function were assessed at 3, 6, and 12 weeks after induction of pulmonary hypertension and were compared with sham animals (n = 5). Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.02.096DOI Listing

Lung Transplant Outcomes in Pulmonary Fibrosis Patients with Telomere-Related Gene Variants.

Chest 2019 Apr 9. Epub 2019 Apr 9.

Duke University Medical Center.

Background: Pulmonary fibrosis (PF) is the most common disease indication for lung transplantation. Our recent work implicated an excess of rare genetic variants in the telomere-related genes TERT, RTEL1, and PARN in PF disease risk. The impact of such variants upon post-transplant outcomes is uncertain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692193081
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http://dx.doi.org/10.1016/j.chest.2019.03.030DOI Listing
April 2019
8 Reads

Current opinion in organ transplantation: lung transplantation.

Curr Opin Organ Transplant 2019 Apr 9. Epub 2019 Apr 9.

The Lung Transplant Unit, St. Vincent's Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1097/MOT.0000000000000644DOI Listing
April 2019
1 Read

Pediatric lung transplantation: supply and demand.

Curr Opin Organ Transplant 2019 Apr 9. Epub 2019 Apr 9.

Division of Pulmonary Medicine, University Hospital Zurich, Zurich, Switzerland.

Purpose Of Review: Lung transplantation has become an accepted therapy in infants, children, and adolescents suffering from end-stage lung diseases, an impaired quality of life and reduced life expectancy. The aim of this review is to highlight specific aspects of pediatric lung transplantation and to give an update on recent findings.

Recent Findings: Currently, over 100 lung transplant procedures are performed in children annually worldwide. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000630DOI Listing
April 2019
1 Read

Extracorporeal membrane oxygenation use in the first 24 hours following pediatric heart transplantation: Incidence, risk factors, and outcomes.

Pediatr Transplant 2019 Apr 11:e13414. Epub 2019 Apr 11.

Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, Tennessee.

Primary graft dysfunction following HTx is associated with significant morbidity and mortality. This study aimed to assess the incidence of, risk factors for, and outcomes of children requiring ECMO within 24 hours of HTx. This study utilized a linked PHIS/SRTR database of pediatric HTx recipients (2002-2016). Read More

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http://dx.doi.org/10.1111/petr.13414DOI Listing
April 2019
1 Read

Lung tissue engineering: An update.

J Cell Physiol 2019 Apr 10. Epub 2019 Apr 10.

Nanotechnology and Regenerative Medicine Commercialization Centre (Ltd), The London Bioscience Innovation Centre, London, UK.

Pulmonary disease is a worldwide public health problem that reduces the life quality and increases the need for hospital admissions as well as the risk of premature death. A common problem is the significant shortage of lungs for transplantation as well as patients must also take immunosuppressive drugs for the rest of their lives to keep the immune system from attacking transplanted organs. Recently, a new strategy has been proposed in the cellular engineering of lung tissue as decellularization approaches. Read More

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http://dx.doi.org/10.1002/jcp.28558DOI Listing
April 2019
4 Reads

First Experience with Extracorporeal Membrane Oxygenation in Iran, under Difficult Conditions.

J Tehran Heart Cent 2018 Oct;13(4):166-172

Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Extracorporeal membrane oxygenation (ECMO) provides hemodynamic and oxygenation support in critical conditions. The commencement of this modality in Iran coincided with severe economic constraints across Iran. This retrospective study was performed in Masih Daneshvari Medical Center from 2010 to 2015, during which period, sanction-related limitations in the import of equipment prompted us to integrate a Medtronic or Stöckert head pump console into a Maquet ECMO Oxygenator so as to sustain the ECMO program. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450813PMC
October 2018
1 Read

Idiopathic Constrictive Pericarditis After Single Lung Transplantation.

Arch Bronconeumol 2019 Apr 7. Epub 2019 Apr 7.

Lung Transplant Group, Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.arbres.2019.02.011DOI Listing
April 2019
1 Read

Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy.

Mol Cancer 2019 Apr 10;18(1):85. Epub 2019 Apr 10.

Division of Cancer Biology, Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, GA, 30322, USA.

Background: Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents that directly targets KRAS may provide a more attractive option for the treatment of KRAS-mutant lung cancer.

Results: Here we identified a small molecule KRAS agonist, KRA-533, that binds the GTP/GDP-binding pocket of KRAS. Read More

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http://dx.doi.org/10.1186/s12943-019-1012-4DOI Listing
April 2019
1 Read

In-hospital and mid-term outcomes in patients reoperated on due to bleeding following coronary artery surgery (from the KROK Registry).

Interact Cardiovasc Thorac Surg 2019 Apr 9. Epub 2019 Apr 9.

Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Silesian Centre for Heart Diseases, Medical University of Silesia, Zabrze, Poland.

Objectives: Surgical re-exploration due to postoperative bleeding that follows coronary artery surgery is associated with significant morbidity and mortality. The aim of this study was to assess a relationship between re-exploration, major postoperative complications, in-hospital mortality and mid-term outcomes in patients following coronary surgery, on the basis of nationwide registry data.

Methods: We identified all consecutive patients enrolled in Polish National Registry of Cardiac Surgical Procedures (KROK Registry) who underwent isolated coronary surgery between January 2012 and December 2014. Read More

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http://dx.doi.org/10.1093/icvts/ivz089DOI Listing
April 2019
2 Reads

Lung donation after circulatory death.

Curr Opin Organ Transplant 2019 Apr 5. Epub 2019 Apr 5.

Department of Thoracic Surgery, University Hospitals Leuven.

Purpose Of Review: The current review presents a concise update on published literature on donation after circulatory death (DCD) and lung transplantation (LTx). Worldwide an increasing need for lungs is evident, however the utilization rate of DCD lung donors is still considerably low. In this summary article, we reviewed both the experimental background and international clinical experience. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000627DOI Listing
April 2019
1 Read

The lung microbiome and transplantation.

Curr Opin Organ Transplant 2019 Apr 5. Epub 2019 Apr 5.

Molecular Biosciences, University of Technology Sydney.

Purpose Of Review: Lung transplantation survival is still limited compared with other solid organ transplant modalities, due to a range of factors that are continuing to be elucidated. However, new research is emerging which indicates that the microbiome of the lungs, and of other organs, may have important implications for immune response and mediating transplant outcomes. Pathogenic bacterial and viral species are known to have deleterious effects on the allograft, but taking a more global view, and considering the overall composition of the community of microbial species may undercover a greater understanding of the complex interplay involved in allograft dysfunction. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000631DOI Listing
April 2019
1 Read

Characteristics, Trends, and Predictors of Specialty Palliative Care Utilization after Lung Transplantation.

J Palliat Med 2019 Apr 9. Epub 2019 Apr 9.

1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Lung transplant recipients who experience serious illness could benefit from specialty palliative care (SPC), but evidence suggests that referral has been rare.

Objective: Examine the characteristics of post-transplant SPC encounters, utilization trends, and patient characteristics associated with SPC at a center with established SPC services.

Design: Retrospective cohort study of SPC utilization by 597 lung transplant recipients transplanted between 2010 and 2015. Read More

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http://dx.doi.org/10.1089/jpm.2018.0560DOI Listing
April 2019
2 Reads

Telomerase Variants in Patients with Cirrhosis Awaiting Liver Transplantation.

Hepatology 2019 Feb 14. Epub 2019 Feb 14.

Norris Comprehensive Cancer Center and Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Telomeres are repetitive DNA sequences that protect the ends of linear chromosomes, and they are maintained by a ribonucleoprotein complex called telomerase. Variants in genes encoding for telomerase components have been associated with a spectrum of disease in the lung, skin, bone marrow, and liver. Mutations in the telomerase reverse transcriptase and telomerase RNA component genes have been observed at a higher prevalence in patients with liver disease compared with the general population; however, the presence of variants in other components of the telomerase complex and their impact on clinical outcomes has not been explored. Read More

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http://dx.doi.org/10.1002/hep.30557DOI Listing
February 2019
1 Read

Osteopontin lung gene expression is a marker of disease severity in pulmonary arterial hypertension.

Respirology 2019 Apr 8. Epub 2019 Apr 8.

Toronto Lung Transplant Program, University of Toronto, Toronto, ON, Canada.

Background And Objective: Osteopontin (OPN) is a pleiotropic cytokine involved in the proliferation of pulmonary artery smooth muscle cells (PA-SMC). OPN is upregulated in the lungs of patients with pulmonary hypertension (PH) associated with pulmonary fibrosis, suggesting that the lung is a source of OPN. We hypothesized that OPN lung expression is elevated in Group I pulmonary arterial hypertension (PAH) and is correlated to haemodynamics. Read More

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http://dx.doi.org/10.1111/resp.13557DOI Listing
April 2019
1 Read

Rituximab Therapy in Interstitial Lung Disease associated with Rheumatoid Arthritis.

Intern Med J 2019 Apr 9. Epub 2019 Apr 9.

Respiratory Diseases and Lung Transplantation Unit, AOUS - Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy.

Rheumatoid Arthrtitis (RA) is a chronic systemic inflammatory disease. In this disease interstitial lung involvement (ILD) is associated with high risk of mortality. Rituximab, a monoclonal antibody directed against CD20, is effective in the treatment of articular manifestations in RA while controversial results have been reported on Rituximab efficacy in RA-ILD patients. Read More

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http://dx.doi.org/10.1111/imj.14306DOI Listing
April 2019
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Measuring physiologic shunt fraction during normothermic ex-vivo lung perfusion to assess transplantability of questionable donor lungs.

Transpl Int 2019 Apr 8. Epub 2019 Apr 8.

Anaesthesiology University Hospitals Leuven, KU Leuven University, Leuven, Belgium.

Lung transplantation as a live-saving treatment for selected patients with end-stage lung disease still suffers from a shortage of suitable lung donors [1]. The process of accepting donor lungs is often based on a subjective decision following a short-term macroscopic evaluation of the pulmonary graft by bronchoscopy, palpation, and inspection inside the donors' chest at the time of multi-organ retrieval [2]. P/F ratio defined as partial pressure of oxygen measured in a systemic artery (PaO ) / fraction of inspired oxygen (FiO ) is the historic clinical gold standard to assess gas exchange of donor lungs in vivo as an estimate of post-transplant pulmonary function. Read More

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http://dx.doi.org/10.1111/tri.13437DOI Listing
April 2019
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Genetic and Molecular Findings of 38 Iranian Patients with Chronic Granulomatous Disease Caused by p47-phox defect.

Scand J Immunol 2019 Apr 8:e12767. Epub 2019 Apr 8.

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

One of the components of NADPH-oxidase is p47-phox; encoded by NCF1 gene. This study aims to find new genetic changes and clinical features in 38 Iranian patients with autosomal recessive chronic granulomatous disease (AR-CGD) caused by NCF1 gene defect. Patients who had abnormal NBT and DHR-1,2,3 assay with loss of p47-phox in western blotting were included in this study. Read More

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http://dx.doi.org/10.1111/sji.12767DOI Listing
April 2019
4 Reads

Implications of fatherhood in cystic fibrosis.

Paediatr Respir Rev 2019 Mar 16. Epub 2019 Mar 16.

Manchester Adult CF Centre, Manchester University Hospital NHS Foundation Trust, Manchester M23 9LT, United Kingdom.

Advances in fertility treatment mean that men with CF are increasingly able to become fathers. Here we report clinical outcomes in 22 men with CF who have become fathers for the first time. Overall mean (SD) FEV predicted declined from 60. Read More

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http://dx.doi.org/10.1016/j.prrv.2019.02.008DOI Listing
March 2019
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Health-related quality of life and stress-related post-transplant trajectories of lung transplant recipients: a three-year follow-up of the Swiss Transplant Cohort Study

Swiss Med Wkly 2019 Feb 24;149(07-08). Epub 2019 Feb 24.

Background: Lung transplantation (LTx) provides a viable option for the survival of end-stage lung diseases. Besides survival as a clinical outcome measure, health-related quality of life (HRQoL) and psychological distress have become important outcomes in studies investigating the effectiveness of LTx in the short- and long-term.

Objective: To assess and compare HRQoL trajectories of patients after LTx prior to and over a follow-up period of three years post-transplant, and to identify differences regarding distress, HRQoL and patient-related outcomes. Read More

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http://dx.doi.org/10.4414/smw.2019.20019DOI Listing
February 2019

Impact of U.S. Public Health Service Increased Risk Deceased Donor Designation on Organ Utilization.

Am J Transplant 2019 Apr 8. Epub 2019 Apr 8.

Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention.

Under U.S. Public Health Service (PHS) guidelines, organ donors with risk factors for human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV) are categorized as Increased Risk Donors (IRD). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.15388
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http://dx.doi.org/10.1111/ajt.15388DOI Listing
April 2019
2 Reads

A Need for Targeted Immunosuppression Following Lung Transplantation.

Authors:
Ankit Bharat

Am J Respir Cell Mol Biol 2019 Apr 8. Epub 2019 Apr 8.

Northwestern University, Chicago, Illinois, United States ;

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http://dx.doi.org/10.1165/rcmb.2019-0100EDDOI Listing
April 2019
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The continuous heart failure spectrum: moving beyond an ejection fraction classification.

Eur Heart J 2019 Apr 8. Epub 2019 Apr 8.

Laboratory of Physiopharmacology, Antwerp University, Universiteitsplein 1, Building T, Wilrijk, Antwerp 2610, Belgium.

Randomized clinical trials initially used heart failure (HF) patients with low left ventricular ejection fraction (LVEF) to select study populations with high risk to enhance statistical power. However, this use of LVEF in clinical trials has led to oversimplification of the scientific view of a complex syndrome. Descriptive terms such as 'HFrEF' (HF with reduced LVEF), 'HFpEF' (HF with preserved LVEF), and more recently 'HFmrEF' (HF with mid-range LVEF), assigned on arbitrary LVEF cut-off points, have gradually arisen as separate diseases, implying distinct pathophysiologies. Read More

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http://dx.doi.org/10.1093/eurheartj/ehz158DOI Listing
April 2019
4 Reads
15.203 Impact Factor

Disseminated central nervous system infection after lung transplantation: A case report with successful recovery.

Med Mycol Case Rep 2019 Jun 16;24:37-40. Epub 2019 Mar 16.

Department of Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Finland.

species are fungal opportunistic pathogens frequently seen in chronic lung diseases such as in cystic fibrosis (CF). They can cause a wide spectrum of diseases mainly in immunodeficient patients. Invasive, disseminated infections with poor prognosis have been described after lung transplantation. Read More

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http://dx.doi.org/10.1016/j.mmcr.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431731PMC
June 2019
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Cytomegalovirus - an unrecognised potential contributor to cystic fibrosis disease progression?

Eur Respir J 2019 Apr 7. Epub 2019 Apr 7.

Department of Medicine, University of Calgary, Calgary, AB, Canada.

Cytomegalovirus (CMV) is a common human beta-herpes virus most notable for causing visceral disease in profoundly immune-suppressed populations, and congenital infections. However, an increasing body of work has demonstrated that CMV seropositivity is associated with a number of chronic medical conditions including heart disease and dementia - potentially related to the effects of chronic inflammation. We hypothesided that the outcomes of individuals with cystic fibrosis (CF), a chronic inflammatory disease, could similarly be associated with CMV-status. Read More

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http://dx.doi.org/10.1183/13993003.01727-2018DOI Listing
April 2019
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Heart transplantation from donation-after-circulatory-death (DCD) donors: Back to the future-Evolving trends in heart transplantation from DCD donors.

J Heart Lung Transplant 2019 Mar 26. Epub 2019 Mar 26.

Cardiothoracic Surgery & Transplantation, Alfred Heart & Lung, The Alfred Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.healun.2019.03.010DOI Listing
March 2019
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