50,657 results match your criteria Lung Transplantation


Comparing posaconazole and itraconazole for antifungal prophylaxis in critically ill lung transplant recipients: efficacy and plasma concentrations.

Transpl Infect Dis 2021 Jun 24:e13675. Epub 2021 Jun 24.

Department of Anesthesiology, University Hospital, LMU Munich, Munich, Germany.

Background: Posaconazole and itraconazole are commonly used for systemic antifungal prophylaxis after lung transplantation. The aim of this study on critically ill lung transplant recipients was to assess the rate of adequate plasma concentrations and the frequency of fungal-induced transitions from antifungal prophylaxis to therapy after the administration of either posaconazole or itraconazole for systemic prophylaxis.

Methods: Critically ill lung transplant recipients with postoperative posaconazole or itraconazole prophylaxis and therapeutic drug monitoring from February 2016 to November 2019 were retrospectively included in the study. Read More

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Impact of tobacco smoking on pulmonary and kidney function after successful kidney transplantation - A single-centre pilot study.

Acta Biochim Pol 2021 Jun 24. Epub 2021 Jun 24.

Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.

The all consequences of tobacco smoking on the lungs and kidney function in kidney transplant recipients are unknown. We investigate the impact of tobacco smoking on lung and kidney functions in kidney transplantation recipients.

Methods: Finally, 55 patients were evaluated after kidney transplantation (age 50. Read More

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Lung ultrasound may help in the differential diagnosis of suspected oligosymptomatic COVID-19 patients on hemodialysis: A case report.

Hemodial Int 2021 Jun 24. Epub 2021 Jun 24.

Nephrology, Dialysis and Transplantation Unit, Careggi University Hospital, Florence, Italy.

Introduction: Considering that patients on dialysis showed a poor outcome during COVID-19 pandemic, and that COVID-19 symptoms in dialysis patients are often mild or absent, each dialysis unit should implement local strategies to early recognize patients affected by COVID-19. However, many available SARS-CoV-2 diagnostic tests demonstrated a moderate sensitivity, 70%-80% is probably a reasonable estimate. Consequently, having useful tools for differential diagnosis becomes essential. Read More

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Preoperative computer tomography-guided indocyanine green injection is associated with successful localization of small pulmonary nodules.

Transl Lung Cancer Res 2021 May;10(5):2229-2236

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

Background: Localization of small pulmonary nodules (SPNs) is challenging in minimally invasive pulmonary resection, and it is unknown whether computer tomography (CT) guided by indocyanine green (ICG) can provide accurate localization with minimal complications.

Methods: We performed a retrospective study of patients who underwent thoracoscopic resection of pulmonary nodules after CT-guided preoperative localization with ICG from May 2019 to May 2020. Demographics, procedural data, postoperative complications, and pathologic information, were collected, and an analysis of the accuracy and complications after surgery was conducted. Read More

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Chronic lung allograft pathology lesions in two rat strain combinations.

J Thorac Dis 2021 May;13(5):2833-2843

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, Padova, Italy.

Background: Chronic lung allograft dysfunction remains an obstacle to long-term survival after lung transplantation. Two phenotypes have been described: obliterative bronchiolitis and restrictive allograft syndrome. Preclinical models are essential to analyze chronic lung allograft dysfunction pathophysiology. Read More

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Combined Liver-Lung-Kidney Transplant in a Patient with Cystic Fibrosis.

Am J Case Rep 2021 Jun 24;22:e930867. Epub 2021 Jun 24.

Department of Medicine, Columbia University Irving Medical Center, New York City, NY, USA.

BACKGROUND Individuals with cystic fibrosis (CF) constituted approximately 10% of organ transplants in 2019, with the majority of transplants consisting of bilateral lung transplant. Multiorgan transplantation in individuals with cystic fibrosis (CF) is rare, and usually involves the liver and lung combined. Since kidney disease is not a common sequela of CF, the need for renal transplant in individuals who have not previously undergone lung transplant is uncommon. Read More

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CFTR Modulators to the Rescue of Individuals with Cystic Fibrosis and Advanced Lung Disease.

Am J Respir Crit Care Med 2021 Jun 23. Epub 2021 Jun 23.

University of Pittsburgh, 6614, Medicine, Pittsburgh, Pennsylvania, United States;

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Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis.

Intensive Care Med 2021 Jun 23. Epub 2021 Jun 23.

Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James's Hospital, Dublin, Ireland.

Purpose: Invasive pulmonary aspergillosis (IPA) is increasingly reported in patients with severe coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Diagnosis and management of COVID-19 associated pulmonary aspergillosis (CAPA) are challenging and our aim was to develop practical guidance.

Methods: A group of 28 international experts reviewed current insights in the epidemiology, diagnosis and management of CAPA and developed recommendations using GRADE methodology. Read More

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Association between pulmonary artery to aorta diameter ratio with pulmonary hypertension and outcomes in diffuse cystic lung diseases.

Medicine (Baltimore) 2021 Jun;100(25):e26483

Divisão de Pneumologia, Instituto do Coração (InCor).

Abstract: To investigate the importance of pulmonary vascular measurements on computed tomography (CT) in predicting pulmonary hypertension (PH) and worse outcomes in diffuse cystic lung diseases (DCLDs).We conducted a cross-sectional study of patients with DCLDs. Patients underwent pulmonary function tests, a six-minute walk test (6MWT), chest CT, transthoracic echocardiography, and right heart catheterization. Read More

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Anesthetic management of lung transplantation in a patient with end-stage COVID-19 pneumonia: A case report.

Medicine (Baltimore) 2021 Jun;100(25):e26468

Department of Anaesthesia, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.

Rationale: The COVID-19 pandemic is spreading around the world and the leading cause of death is rapidly progressive respiratory failure because of lung damage and consolidation. Lung transplantation is the last line of treatment for chronic end-stage lung diseases. There were several cases of lung transplantation reported in patients with COVID-19 pneumonia. Read More

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Broadening the phenotypic spectrum of Beta3GalT6-associated phenotypes.

Am J Med Genet A 2021 Jun 23. Epub 2021 Jun 23.

Center for Rare Diseases and Birth Defects, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Biallelic mutations in B3GALT6, coding for a galactosyltransferase involved in the synthesis of glycosaminoglycans (GAGs), have been associated with various clinical conditions, causing spondyloepimetaphyseal dysplasia with joint laxity type 1 (SEMDJL1 or SEMDJL Beighton type), Al-Gazali syndrome (ALGAZ), and a severe progeroid form of Ehlers-Danlos syndrome (EDSSPD2). In the 2017 Ehlers-Danlos syndrome (EDS) classification, Beta3GalT6-related disorders were grouped in the spondylodysplastic EDSs together with spondylodysplastic EDSs due to B4GALT7 and SLC39A13 mutations. Herein, we describe a patient with a previously unreported homozygous pathogenic B3GALT6 variant resulting in a complex phenotype more severe than spondyloepimetaphyseal dysplasia with joint laxity type 1, and having dural ectasia and aortic dilation as additionally associated features, further broadening the phenotypic spectrum of the Beta3GalT6-related syndromes. Read More

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Characteristics and outcomes among lung transplant patients with respiratory syncytial virus infection.

Transpl Infect Dis 2021 Jun 22:e13661. Epub 2021 Jun 22.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: To describe characteristics and outcomes among lung transplantation (LT) patients with respiratory syncytial virus (RSV) infection and elucidate the predictors of 1-year survival after RSV infection.

Methods: This was a retrospective chart review study among LT patients with RSV infection between 2013 and 2018 (90 episodes among 87 patients; mean age 56.3 ± 13. Read More

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Successful lung transplantation after prone positioning in an ineligible donor: a case report.

Gen Thorac Cardiovasc Surg 2021 Jun 22. Epub 2021 Jun 22.

Department of Internal Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

Atelectasis is a reversible factor in hypoxemia among brain-dead donors. In ineligible donors, prone positioning reverses atelectasis and improves oxygenation. We present a successful lung transplantation after salvaging a previously unviable lung. Read More

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Influence of an Acute Exacerbation During Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease Awaiting Lung Transplantation.

J Cardiopulm Rehabil Prev 2021 Jul;41(4):267-270

Department of Pulmonary Rehabilitation (Drs Gloeckl, Jarosch, Koczulla, and Kenn and Mss Leitl and Schneeberger), and Division of Pulmonary Diseases, Department of Internal Medicine (Dr Nell), German Center for Lung Research (DZL), Philipps University of Marburg, Marburg, Germany; Institute for Pulmonary Rehabilitation Research, Schoen Klinik Berchtesgadener Land, Schoenau am Koenigssee, Germany (Drs Gloeckl, Jarosch, Koczulla, and Kenn and Mss Leitl and Schneeberger); Research Group for Cardiovascular and Respiratory Rehabilitation, Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, Belgium (Dr Langer); Respiratory Rehabilitation and Respiratory Division, University Hospital Leuven, Leuven, Belgium (Dr Langer); and Teaching Hospital, Paracelsus Medical University, Salzburg, Austria (Dr Koczulla).

Purpose: Pulmonary rehabilitation (PR) has been shown to be an effective intervention in patients with very severe chronic obstructive pulmonary disease (COPD) awaiting lung transplantation (LTx). The objective of this study was to characterize the prevalence of acute exacerbations (AEs) during PR and their impact on the outcomes of pre-LTx PR.

Methods: In this retrospective analysis, 559 patients with COPD awaiting LTx who were referred to a 4-wk inpatient PR program were evaluated. Read More

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Does Size Matter for Female Continuous-flow LVAD Recipients? A Translational Approach to a Decade Long Question.

ASAIO J 2021 Jun 11. Epub 2021 Jun 11.

From the *Product Development Group Zurich, ETH Zurich, Zurich, Switzerland †Department of Radiology, Stanford University, Stanford, California ‡Cardiovascular Institute, Stanford University, Stanford, California §Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia ¶Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia ‖Division of Cardiovascular Medicine, Department of Medicine, Henry Ford Hospital, Detroit, Michigan #Department of Internal Medicine, Wayne State University, Detroit, Michigan.

Females have increased risk of right-ventricular failure (RVF) and 3 month mortality after left-ventricular assist device (LVAD) implantation. In this translational study, we tested the hypothesis that sex differences in outcomes are driven by pump-induced LV size-volume mismatch, due to a negative impact on interventricular septal (IVS) interdependence. Adult continuous-flow LVAD recipients from the International Society For Heart And Lung Transplantation Mechanically Assisted Circulatory Support registry (n = 15,498) were studied to determine association of female sex with outcomes of 3 month mortality and RVF. Read More

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Small Airway Disease and Emphysema Are Associated with Future Exacerbations in Smokers with CT-derived Bronchiectasis and COPD: Results from the COPDGene Cohort.

Radiology 2021 Jun 22:204052. Epub 2021 Jun 22.

From the Division of Pulmonary Diseases and Critical Care, the University of Texas Health Science Center at San Antonio, San Antonio, Tex (D.J.M., A.A., M.I.R.); Department of Radiology, University of California, San Diego, Calif (A.Y.); Division of Sleep Medicine and Circadian Disorders (W.W.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (W.R.D., A.A.D.), and Department of Radiology (R.S.J.E.), Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115; Department of Radiology, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan (Y.O.); Quinnipiac University School of Medicine, Hamden, Conn (C.M.); South Texas Veterans Health Care System, San Antonio, Tex (A.A., M.I.R.); Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); Division of Pulmonary, Critical Care & Sleep Medicine, New York University School of Medicine, New York, NY (A.B.); Department of Pathophysiology and Transplantation, University of Milan Internal Medicine, and Respiratory Unit and Cystic Fibrosis Adult Center, Milan, Italy (S.A.); Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.); Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Ala (J.M.W.); and Department of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Background Chronic obstructive pulmonary disease (COPD) and bronchiectasis can overlap and share pathologic features, such as small airway disease (SAD). Whether the presence of SAD and emphysema in smokers with CT-derived bronchiectasis is associated with exacerbations is unknown. Purpose To assess whether SAD and emphysema in smokers with CT-derived bronchiectasis are associated with future exacerbations. Read More

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Effect of neridronate in osteopenic patients after heart, liver or lung transplant: a multicenter, randomized, double-blind, placebo-controlled study.

Panminerva Med 2021 Jun;63(2):214-223

Department of Medicine (DIMED), Clinica Medica Uno, University of Padua, Padua, Italy.

Background: Transplantation (Tx) is an effective therapeutic option in patients with end-stage organ failure and osteoporosis and related fractures are a recognized complication in these patients. Aim of this study was to evaluate the efficacy of neridronate in patients with reduced bone mass after Tx of the heart, liver or lung.

Methods: In this multicenter randomized double-blind controlled trial (RCT), 22 patients were treated with neridronate (25 mg i. Read More

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Incidence of Herpes Zoster in Adult Solid Organ Transplant Recipients: A Meta-analysis and Comprehensive Review.

Transpl Infect Dis 2021 Jun 21:e13674. Epub 2021 Jun 21.

Division of Infectious Disease, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Chronic immunosuppressive therapy in solid organ transplant (SOT) recipients can trigger latent varicella zoster virus reactivation even in those with stable graft function. The inactivated herpes zoster (HZ) vaccine can be effective in preventing post-transplant HZ, which can cause severe neuralgia or disseminated disease. This meta-analysis aims to assess the incidences of HZ across transplant organs in SOT recipients. Read More

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Single-center experience of organ transplant practice during the COVID-19 epidemic.

Transpl Int 2021 Jun 21. Epub 2021 Jun 21.

Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.

In order to safely carry out organ donation transplants during the outbreak of coronavirus disease 2019 (COVID-19), we have formulated strict procedures in place for organ donation and transplantation. We retrospectively analyzed our transplantation work from January 20 to May 5, 2020 to discuss whether organ transplantation can be carried out safely during the epidemic period. From January 20 to May 5, 43 cases of donation were carried out in our hospital, and the utilization rate of liver, kidney, heart, lung and pancreas donations was more than 90%. Read More

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Hepatocyte proteomes reveal the role of protein disulfide isomerase 4 in alpha 1-antitrypsin deficiency.

JHEP Rep 2021 Aug 24;3(4):100297. Epub 2021 Apr 24.

University of Bordeaux, CNRS, INSERM, BaRITOn, U1053, Bordeaux, France.

Background & Aims: A single point mutation in the Z-variant of alpha 1-antitrypsin (Z-AAT) alone can lead to both a protein folding and trafficking defect, preventing its exit from the endoplasmic reticulum (ER), and the formation of aggregates that are retained as inclusions within the ER of hepatocytes. These defects result in a systemic AAT deficiency (AATD) that causes lung disease, whereas the ER-retained aggregates can induce severe liver injury in patients with ZZ-AATD. Unfortunately, therapeutic approaches are still limited and represents the option To overcome this limitation, a better understanding of the molecular basis of ER aggregate formation could provide new strategies for therapeutic intervention. Read More

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Comparative Transcriptome Analyses Reveal a Transcriptional Landscape of Human Silicosis Lungs and Provide Potential Strategies for Silicosis Treatment.

Front Genet 2021 3;12:652901. Epub 2021 Jun 3.

State Key Laboratory of Medical Molecular Biology, Department of Physiology, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China.

Silicosis is a fatal occupational lung disease which currently has no effective clinical cure. Recent studies examining the underlying mechanism of silicosis have primarily examined experimental models, which may not perfectly reflect the nature of human silicosis progression. A comprehensive profiling of the molecular changes in human silicosis lungs is urgently needed. Read More

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Correlation Between Skin and Affected Organs in 52 Sclerodermic Patients Followed in a Diseases Management Team: Development of a Risk Prediction Model of Organ-Specific Complications.

Front Immunol 2021 2;12:588753. Epub 2021 Jun 2.

Dermatologic Unit, University of Genoa, DiSSal, Ospedale-Policlinico San Martino, IRCCS, Genova, Italy.

Objective: To identify the existence of a correlation among the various organs affected, focusing primarily on immuno-dermatological aspects, and to create a risk prediction model of organ-specific complications.

Material And Methods: Fifty-two patients with stable scleroderma, followed between 2015 and 2019, were investigated through an extensive multidisciplinary evaluation in the last year.

Results: Patients with lung involvement presented a worse degree of skin fibrosis than patients without it (p <0. Read More

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Therapeutic utility of levosimendan during the postoperative period of lung transplantation: initial experience in right ventricular dysfunction.

Rev Esp Anestesiol Reanim 2021 Jun 17. Epub 2021 Jun 17.

Grupo de Trasplante Pulmonar, Servicio de Anestesiología y Reanimación Complejo Hospitalario Universitario de A Coruña, A Coruña, España.

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Adipose-derived stem cells therapy effectively attenuates PM-induced lung injury.

Stem Cell Res Ther 2021 Jun 19;12(1):355. Epub 2021 Jun 19.

College of Life Science, University of Chinese Academy of Sciences, 19A Yuquanlu, Beijing, 100049, China.

Background: The adverse health effects of fine particulate matter (PM) exposure are associated with marked inflammatory responses. Adipose-derived stem cells (ADSCs) have immunosuppressive effects, and ADSC transplantation could attenuate pulmonary fibrosis in different animal disease models. However, whether ADSCs affect PM-induced lung injury has not been investigated. Read More

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Heterozygous gain-of-function variants cause an autoinflammatory immunodeficiency.

Sci Immunol 2021 Jun;6(60)

Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.

Analysis of autoinflammatory and immunodeficiency disorders elucidates human immunity and fosters the development of targeted therapies. Oligoadenylate synthetase 1 is a type I interferon-induced, intracellular double-stranded RNA (dsRNA) sensor that generates 2'-5'-oligoadenylate to activate ribonuclease L (RNase L) as a means of antiviral defense. We identified four de novo heterozygous gain-of-function variants in six patients with a polymorphic autoinflammatory immunodeficiency characterized by recurrent fever, dermatitis, inflammatory bowel disease, pulmonary alveolar proteinosis, and hypogammaglobulinemia. Read More

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A high-resolution cell atlas of the domestic pig lung and an online platform for exploring lung single-cell data.

J Genet Genomics 2021 Apr 30. Epub 2021 Apr 30.

Institute of Pediatrics, Department of Pediatric Surgery, Shenzhen Children's Hospital, Shenzhen 518038, China; Department of Pediatrics, The Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China. Electronic address:

The genetically engineered pig is regarded as an optimal source of human organs for transplantation and an excellent model for human disease research, given its comparable physiology to human beings. A myriad of single-cell RNA sequencing (scRNA-seq) data on humans has been reported, but such data on pigs are scarce. Here, we apply scRNA-seq technology to study the cellular heterogeneity of 3-month-old pig lungs, generating the single-cell atlas of 13,580 cells covering 16 major cell types. Read More

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COVID-19 vaccination immune paresis in heart and lung transplantation.

J Heart Lung Transplant 2021 May 13. Epub 2021 May 13.

Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, Massachusetts. Electronic address:

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Early implementation of renal replacement therapy after lung transplantation does not impair long-term kidney function in patients with idiopathic pulmonary arterial hypertension.

J Thorac Cardiovasc Surg 2021 Jun 1. Epub 2021 Jun 1.

Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria. Electronic address:

Objectives: In patients with idiopathic pulmonary arterial hypertension, cardiac function can be impaired in the early postoperative phase after lung transplantation because the chronically untrained left ventricle is prone to fail. Thus, restrictive fluid management is pivotal to unload the left heart. In our institution, continuous renal replacement therapy is implemented liberally whenever a patient cannot be balanced negatively. Read More

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