47,703 results match your criteria Lung Transplantation


Severe COVID-19 in a patient with chronic graft-versus-host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib.

Transpl Infect Dis 2020 Jul 6:e13401. Epub 2020 Jul 6.

Hematology and Stem Cell Transplant, Ancona University Hospital, Ancona, Italy.

Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant, which is known to be mediated by cytotoxic T-cell effectors and dysregulated inflammatory cytokines. Similarly, the lung injury observed in severe COVID-19 cases appears to be related to a massive production of proinflammatory cytokines. The selective JAK1/2 inhibitor ruxolitinib has shown promising results in the context of GVHD, and different trials are currently underway in patients with severe COVID-19; nevertheless no clinical observation of safety or efficacy of treatment with ruxolitinib in this context has been published yet. Read More

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http://dx.doi.org/10.1111/tid.13401DOI Listing

Generation of functional lungs with pluripotent stem cells.

Allergy 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario "A Gemelli" - IRCCS, University of the Sacred Heart. Rome, Italy.

Millions of people of all ages suffer from chronic respiratory diseases (CRDs), including asthma, respiratory allergies and chronic obstructive pulmonary disease. To date, although significant advances have been made in terms of treatment, end-stage CRDs still remains one of the most frequent causes of death worldwide with a death rate that has been increasing over the past few years. Lung transplantation is the only therapeutic option when other treatments fail. Read More

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http://dx.doi.org/10.1111/all.14485DOI Listing

The Association of Increased FFP:RBC Transfusion Ratio to Primary Graft Dysfunction in Bleeding Lung Transplantation Patients.

J Cardiothorac Vasc Anesth 2020 Jun 7. Epub 2020 Jun 7.

Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC.

Objectives: Lung transplantation is associated with a significant risk of needed transfusion. Although algorithm-based transfusion strategies that promote a high fresh frozen plasma:red blood cells (FFP:RBC) ratio have reduced overall blood product requirements in other populations, large-volume transfusions have been linked to primary graft dysfunction (PGD) in lung transplantation, particularly use of platelets and plasma. The authors hypothesized that in lung transplant recipients requiring large-volume transfusions, a higher FFP:RBC ratio would be associated with increased PGD severity at 72 hours. Read More

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http://dx.doi.org/10.1053/j.jvca.2020.05.043DOI Listing

Urgently listed lung transplant patients have outcomes similar to those of electively listed patients.

J Thorac Cardiovasc Surg 2020 Apr 21. Epub 2020 Apr 21.

Department of Thoracic and Cardiovascular Surgery, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio; Transplant Institute, Cleveland Clinic, Cleveland, Ohio; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Objectives: To (1) determine outcomes after urgent listing compared with elective listing for lung transplant and (2) compare in-hospital morbidity and mortality, survival, and allograft function in these 2 groups.

Methods: From January 2006 to September 2017, 201 patients were urgently and 1423 electively listed. Among urgently listed patients, 130 subsequently underwent primary lung transplant as did 995 electively listed patients. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.02.140DOI Listing

Population pharmacokinetics and dosing regimen optimization of tacrolimus in Chinese lung transplant recipients.

Eur J Pharm Sci 2020 Jul 1:105448. Epub 2020 Jul 1.

Department of Lung Transplant Center, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, PR China. Electronic address:

We aimed to (i) develop a population pharmacokinetic model of tacrolimus in Chinese lung transplant recipients and (ii) propose model-based dosing regimens for individualized treatment. We obtained 807 tacrolimus steady-state whole blood concentrations from 52 lung transplant patients and genotyped CYP3A5*3. Population pharmacokinetic analysis was performed using nonlinear mixed-effects modeling. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105448DOI Listing

Impact of Early Initiation of Direct-Acting Antiviral Therapy in Thoracic Organ Transplantation from Hepatitis C Virus Positive Donors.

Semin Thorac Cardiovasc Surg 2020 Jul 1. Epub 2020 Jul 1.

Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY.

Thoracic organs from Hepatitis C virus (HCV) positive donors are not commonly used for transplantation. The development of direct-acting antivirals (DAA) for HCV treatment has led to renewed interest in using HCV-positive organs. We evaluated HCV transmission rates, viremia clearance, and short-term outcomes in HCV-negative patients who received HCV-positive thoracic organs at our institution. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2020.06.045DOI Listing

Current Precautions and Future Directions in Lung Transplantation during the COVID-19 Pandemic.

Transpl Int 2020 Jul 3. Epub 2020 Jul 3.

Division of Cardiovascular Surgery, Department of Surgery, Philadelphia, United States.

The unprecedented public health emergency caused by the acute viral respiratory coronavirus disease (COVID-19) has drastically changed current practices in solid organ transplantation, markedly so for transplantation of the lungs, the major target of the virus. Although national and state authorities do not recommend postponing transplant procedures, most specialists are reluctant to proceed due to substantial uncertainty and increased risks in the midst of the pandemic. There is an urgent need for evidence-based directions to move forward. Read More

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http://dx.doi.org/10.1111/tri.13694DOI Listing

Characteristics and outcomes of lung cancer in solid organ transplant recipients.

Lung Cancer 2020 Jun 20;146:297-302. Epub 2020 Jun 20.

Columbia University Medical Center, Herbert Irving Pavilion, 161 Fort Washington Avenue, New York, NY 10032, United States; Department of Medicine, Columbia University Medical Center, United States. Electronic address:

Objectives: Lung cancer is the third most common malignancy that develops in patients following solid organ transplantation and is the leading cause of cancer deaths in the general population. The aims of this study are to examine the characteristics of patients who developed lung cancer following solid organ transplantation at our institution and to compare their outcomes to those of lung cancer patients without a history of transplant.

Materials And Methods: We performed a single-institution retrospective study of 44 solid organ transplant recipients who developed lung cancer and compared their characteristics to a cohort of 74 lung cancer patients without a history of transplant. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.018DOI Listing

Simultaneous pectus excavatum correction and lung transplantation - a case series.

Am J Transplant 2020 Jul 3. Epub 2020 Jul 3.

Division of Thoracic surgery, Medical University of Vienna, Austria.

Severe chest wall deformities are considered an absolute contraindication for lung transplantation. The significantly impaired chest compliance associated with pectus excavatum is thought to result in a high risk of postoperative respiratory complications and significant morbidity and mortality. We herein report our pooled institutional experience consisting of three patients who underwent bilateral lung transplantation and simultaneous correction of a pectus excavatum. Read More

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http://dx.doi.org/10.1111/ajt.16180DOI Listing

Late atrial arrhythmias after lung transplantation: a meta-analysis.

J Cardiovasc Med (Hagerstown) 2020 Aug;21(8):577-582

Division of Cardiology, Department of Medical Sciences, 'Città della Salute e della Scienza di Torino' Hospital, University of Turin, Turin.

Background: Atrial arrhythmias are common following noncardiac thoracic surgery. In particular, early postoperative atrial arrhythmias after lung transplantation are very frequent, especially atrial fibrillation (AFib). Late atrial arrhythmia occurrence following lung transplantation, instead, has been less commonly reported. Read More

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http://dx.doi.org/10.2459/JCM.0000000000001012DOI Listing

Update on Nocardia infections in solid-organ transplantation.

Curr Opin Organ Transplant 2020 Jun 30. Epub 2020 Jun 30.

Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA.

Purpose Of Review: Nocardia is a ubiquitous pathogen associated with life-threatening opportunistic infections. Organ transplant recipients are uniquely predisposed to Nocardia infections due to their iatrogenic cell-mediated immune deficit necessary to maintain allograft function. This review aims to address recent updates in the epidemiology, clinical presentation, diagnostics, treatment, and outcomes of Nocardia infections in solid-organ transplant recipients. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000793DOI Listing

Multidrug-resistant bacteria in lung transplantation.

Curr Opin Organ Transplant 2020 Jun 30. Epub 2020 Jun 30.

Division of Infectious Diseases, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.

Purpose Of Review: The review of infections in lung transplantation is beyond the scope of this article as it is a comprehensive topic, however we aim to focus on infections with multidrug-resistant (MDR) microorganisms in this patient population.

Recent Findings: New emerging clinical studies have provided data regarding outcomes in lung transplant recipients with MDR bacterial infections.

Summary: Isolation of MDR bacteria from lung donors preoperatively has not been associated with worse outcomes in recipients. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000782DOI Listing

Current state of kidney utilization in multiorgan transplants.

Curr Opin Organ Transplant 2020 Jun 30. Epub 2020 Jun 30.

Department of Surgery, Division of Hepatobiliary, Pancreas, and Abdominal Organ Transplant, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Purpose Of Review: In the United States, the leading indication for kidney transplant is primary kidney dysfunction arising from chronic hypertension and diabetes. However, an increasing indication for kidney transplantation is secondary kidney dysfunction in the setting of another severe organ dysfunction, including pancreas, liver, heart, and lung disease. In these settings, multiorgan transplantation is now commonly performed. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000777DOI Listing

Tumor rupture in hepatoblastoma: A high risk factor?

Pediatr Blood Cancer 2020 Jul 3:e28549. Epub 2020 Jul 3.

Gustave Roussy, Department of Children and Adolescents Oncology, Université Paris-Saclay, Villejuif, France.

Background: Hepatoblastoma tumor rupture is a high-risk criterion in the SIOPEL 3/4 protocol. Little is known about the outcome of these children.

Methods: Radiological signs of possible tumor rupture, defined as peritoneal effusion, peritoneal nodules, or hepatic subcapsular hematoma, were reported in 24 of 150 patients treated for hepatoblastoma in France from January 2000 to December 2014 after central radiological expert review. Read More

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http://dx.doi.org/10.1002/pbc.28549DOI Listing

High-dose intranasal application of titanium dioxide nanoparticles induces the systemic uptakes and allergic airway inflammation in asthmatic mice.

Respir Res 2020 Jul 2;21(1):168. Epub 2020 Jul 2.

Department of Experimental Pneumology and Allergology, Faculty of Medicine, Saarland University, Homburg, Germany.

Background: Titanium dioxide nanoparticles (TiO NPs) have a wide range of applications in several industrial and biomedical domains. Based on the evidence, the workers exposed to inhaled nanosized TiO powder are more susceptible to the risks of developing respiratory diseases. Accordingly, this issue has increasingly attracted the researchers' interest in understanding the consequences of TiO NPs exposure. Read More

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http://dx.doi.org/10.1186/s12931-020-01386-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331175PMC

Vaccination coverage of recommended vaccines and determinants of vaccination in at-risk groups.

Hum Vaccin Immunother 2020 Jul 2:1-8. Epub 2020 Jul 2.

Leuven University Vaccinology Center , Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.

Upon exposure to vaccine-preventable diseases, certain individuals are at increased risk for complications due to preexisting diseases, age or immunosuppressive treatment. Vaccination against influenza, pneumococcal disease and hepatitis B (for some groups) is advised in addition to standard vaccination against diphtheria, tetanus and pertussis. We estimated the vaccination coverage and determinants of recommended vaccinations in patients with diabetes mellitus type 1 (n = 173) and type 2 (n = 177), chronic kidney disease (CKD) (n = 138), heart failure (n = 200), chronic obstructive pulmonary disease (COPD) (n = 187), HIV (n = 201) or solid organ transplantation (SOT) (n = 201) in a monocentric study. Read More

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http://dx.doi.org/10.1080/21645515.2020.1763739DOI Listing

Krebs von den Lungen-6 as biomarker for disease severity assessment in interstitial lung disease: a comprehensive review.

Biomark Med 2020 Jul 2. Epub 2020 Jul 2.

Respiratory Diseases & Lung Transplantation, Department of Medical & Surgical Sciences & Neurosciences, Siena University Hospital, Siena, Italy.

Interstitial lung diseases (ILD) are a group of lung disorders characterized by interstitial lung thickening. Krebs von den Lungen-6 (KL-6) is a molecule that is predominantly expressed by damaged alveolar type II cells and it has been proposed as a potential biomarker of different ILD. A growing literature about KL-6 has been reviewed and selected to evaluate its role in the clinical management of ILD to predict disease diagnosis, activity, prognosis and treatment response. Read More

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http://dx.doi.org/10.2217/bmm-2019-0545DOI Listing

Cytomegalovirus infection as an underestimated trigger for checkpoint inhibitor-related pneumonitis in lung cancer: a retrospective study.

Clin Transl Oncol 2020 Jul 1. Epub 2020 Jul 1.

State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital, Guangzhou Medical University, 151# Yanjiang Road, Guangzhou, 510120, China.

Objectives: Checkpoint inhibitor-related pneumonitis (CIP) is a rare but potentially fatal complication of immune checkpoint inhibitors (ICIs). At present, the mechanism of CIP is not completely clear. Cytomegalovirus (CMV) infection is widespread in the population. Read More

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http://dx.doi.org/10.1007/s12094-020-02432-5DOI Listing

Cardiac safe hematopoietic stem cell transplantation for systemic sclerosis with poor cardiac function: a pilot safety study that decreases neutropenic interval to 5 days.

Bone Marrow Transplant 2020 Jul 1. Epub 2020 Jul 1.

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

We compared three fludarabine-based regimens for systemic sclerosis patients with a high-risk cardiac phenotype that according to EBMT criteria would be a contraindication for a high-dose cyclophosphamide (200 mg/kg) transplant regimen. All three regimens included fludarabine, ATG, and cyclophosphamide (60 mg/kg), while two regimens also included rituximab with or without IVIG. Treatment related mortality (TRM) was 2. Read More

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http://dx.doi.org/10.1038/s41409-020-0978-2DOI Listing

Toothpick Aspiration Induces Massive Hemoptysis: a Case Report.

Tanaffos 2019 Apr;18(4):369-372

Clinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Massive hemoptysis refers to bleeding from the sputum exceeding 100 ml/day. This condition is known to have a poor prognosis. Although foreign body aspiration is not as common as other risk factors, it may result in massive hemoptysis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309886PMC

Thymoma Recurrence and its Predisposing Factors in Iranian Population: a Single Center Study.

Tanaffos 2019 Apr;18(4):355-364

Lung Transplantation Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Thymoma is relatively rare tumor. Prognosis and patients' outcome vary across different studies. We aimed to study the predisposing factors causing tumor recurrence in thymoma patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309889PMC

Evaluation of the Effects of E-Learning on Nurses' Behavior and Knowledge Regarding Venous Thromboembolism.

Tanaffos 2019 Apr;18(4):338-345

Chronic Respiratory Diseases Research center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Continuing medical education (CME) is an integral part of nursing professionalization, which can be effective in the development of nursing behavior. E-learning can play an important role in CME programs. This study aimed to evaluate the effectiveness of an E-learning program in increasing the nurses' knowledge and behavior regarding care for venous thromboembolism (VTE) patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309888PMC

Outcomes and Complications of Bronchial Angioembolization in Patients with Massive Hemoptysis.

Tanaffos 2019 Apr;18(4):310-314

Lung Transplantation Research Center, Department of Cardiology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Massive hemoptysis is a potentially life threatening medical condition and one major problem for both patients and physicians. Choosing the appropriate treatment for the patients is crucial in order to decrease the complications and increase the success rate. Hence, in this study the outcomes and complications of bronchial angioembolization (BAE) were determined in patients with massive hemoptysis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309885PMC

Enhancing Care for Individuals with Advanced Cystic Fibrosis Lung Disease.

Pediatr Pulmonol 2020 Jul 1. Epub 2020 Jul 1.

Department of Pediatrics, Division of Pulmonology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

While remarkable advances in cystic fibrosis (CF) care have led to improvements in survival and quality of life, many individuals with CF are living with advanced cystic fibrosis lung disease (ACFLD) and others will face continued disease progression and its associated complex treatments and choices. This review will provide a summary of recently published guidelines for ACFLD care and lung transplant referral and highlight ongoing work to enhance care of those with ACFLD through improvements in medical and psychosocial care, palliative care, and care around lung transplantation. This article is protected by copyright. Read More

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http://dx.doi.org/10.1002/ppul.24937DOI Listing

Intracerebral abscess due to Cutibacterium acnes after lung transplantation.

Transpl Infect Dis 2020 Jul 1:e13398. Epub 2020 Jul 1.

University Hospital Gasthuisberg, Dept. Respiratory Disease, UZ Leuven, Leuven, Belgium.

Cutibacterium (C.) acnes, a Gram-positive bacterium that is part of the commensal flora, is increasingly noticed as an opportunistic pathogen in serious infections in both immunocompromised and immunocompetent patients. The indolent character and often difficult identification because of its slow growth contribute to delayed diagnosis or underdiagnosis. Read More

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http://dx.doi.org/10.1111/tid.13398DOI Listing

Panel-Reactive and Donor-Specific Antibodies before Lung Transplantation can Affect Outcomes in Korean Patients Receiving Lung Transplantation.

Yonsei Med J 2020 Jul;61(7):606-613

Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Data on the distribution and impact of panel reactive antibodies (PRA) and donor specific antibodies (DSA) before lung transplantation in Asia, especially multi-center-based data, are limited. This study evaluated the prevalence of and effects of PRA and DSA levels before lung transplantations on outcomes in Korean patients using nationwide multicenter registry data.

Materials And Methods: This study included 103 patients who received a lung transplant at five tertiary hospitals in South Korea between March 2015 and December 2017. Read More

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http://dx.doi.org/10.3349/ymj.2020.61.7.606DOI Listing

Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore.

Transplant Direct 2020 Jun 8;6(6):e554. Epub 2020 May 8.

Department of Infectious Diseases, Singapore General Hospital, Singapore.

The current coronavirus disease 2019 (COVID-19) pandemic has not only caused global social disruptions but has also put tremendous strain on healthcare systems worldwide. With all attention and significant effort diverted to containing and managing the COVID-19 outbreak (and understandably so), essential medical services such as transplant services are likely to be affected. Closure of transplant programs in an outbreak caused by a highly transmissible novel pathogen may be inevitable owing to patient safety. Read More

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http://dx.doi.org/10.1097/TXD.0000000000001002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266363PMC

Ultrasound-guided double central venous access for azygos vein via the ninth and tenth intercostal veins.

J Vasc Access 2020 Jun 30:1129729820937133. Epub 2020 Jun 30.

Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.

Some patients with intestinal failure, who are dependent on total parenteral nutrition for long periods, suffer from a lack of suitable conventional venous access points, including axillary, external jugular, internal jugular, subclavian, saphenous, and the brachio-cephalic and femoral veins, due to their occlusion. Furthermore, extensive central venous stenosis and/or thrombosis of the superior and inferior vena cava may preclude further catheterization, so uncommon routes must be used, which can be challenging. In such patients, the azygos vein via the intercostal vein is a viable candidate. Read More

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http://dx.doi.org/10.1177/1129729820937133DOI Listing

Using thin film freezing to minimize excipients in inhalable tacrolimus dry powder formulations.

Int J Pharm 2020 Jun 27;586:119490. Epub 2020 Jun 27.

The University of Texas at Austin, College of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery, Austin, TX, USA. Electronic address:

We investigated the feasibility of preparing high-potency tacrolimus dry powder for inhalation using thin film freezing (TFF). We found that using ultra-rapid freezing can increase drug loading up to 95% while maintaining good aerosol performance. Drug loading affected the specific surface area and moisture sorption of TFF formulations, but it did not affect the chemical stability, physical stability, and dissolution of tacrolimus. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119490DOI Listing

Vitamin D modulates E-cadherin turnover by regulating TGF-β and Wnt signalings during EMT-mediated myofibroblast differentiation in A459 cells.

J Steroid Biochem Mol Biol 2020 Jun 27:105723. Epub 2020 Jun 27.

Lung Transplantation Center, Department of Thoracic Surgery, Kartal Kosuyolu High Speciality Educational and Research Hospital, Kartal, Istanbul, Turkey. Electronic address:

Vitamin D (VitD) has an anti-fibrotic effect on fibrotic lungs. It reduces epithelial-mesenchymal transition (EMT) on tumors. We aimed to investigate target proteins of VitD for the regression of EMT-mediated myofibroblast differentiation. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105723DOI Listing

Transforming Diagnostics in Lung Transplantation: From Bronchoscopy to an A.I.-driven Approach.

Am J Respir Crit Care Med 2020 Jun 30. Epub 2020 Jun 30.

Temple University, 6558, Cardiovascular Surgery, Philadelphia, Pennsylvania, United States;

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http://dx.doi.org/10.1164/rccm.202005-1821EDDOI Listing

Lung perfusion scintigraphy to detect chronic lung allograft dysfunction after living-donor lobar lung transplantation.

Sci Rep 2020 Jun 29;10(1):10595. Epub 2020 Jun 29.

Department of General Thoracic Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama-City, Okayama, 700-8558, Japan.

Because chronic lung allograft dysfunction (CLAD) develops predominantly on one side after bilateral living-donor lobar lung transplantation (LDLLT), lung perfusion scintigraphy (Q-scinti) was expected to show a perfusion shift to the contralateral unaffected lung with the development of CLAD. Our study examined the potential usefulness of Q-scinti in the diagnosis of CLAD after bilateral LDLLT. We conducted a single-center retrospective cohort study of 58 recipients of bilateral LDLLT. Read More

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http://dx.doi.org/10.1038/s41598-020-67433-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324574PMC

Ulcerated nodule in a 50-year old man who underwent lung transplantation.

CMAJ 2020 Jun;192(26):E715

Division of Dermatology (Lemieux), Department of Medicine; Department of Pathology (Belisle) and Division of Infectious Diseases (Luong), Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Que.

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http://dx.doi.org/10.1503/cmaj.191540DOI Listing

Bariatric surgery to achieve transplant in end-stage organ disease patients: A systematic review and meta-analysis.

Am J Surg 2020 Jun 13. Epub 2020 Jun 13.

University of Alabama at Birmingham Schools of Medicine, Department of Surgery, United States.

Background: As obesity prevalence grows, more end-stage organ disease patients will be precluded from transplant. Numerous reports suggest bariatric surgery in end-stage organ disease may help patients achieve weight loss sufficient for transplant listing.

Methods: We performed a systematic review/meta-analysis of studies of bariatric surgery to achieve solid organ transplant listing. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.04.041DOI Listing

Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol.

BMC Nephrol 2020 Jun 29;21(1):242. Epub 2020 Jun 29.

Department of Imaging, Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.

Background: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but these have modest value for predicting future renal status. There is an unmet need for biomarkers that can be used in clinical settings which also improve prediction of renal decline on top of routinely available data, particularly in the early stages. Read More

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http://dx.doi.org/10.1186/s12882-020-01901-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323369PMC

Immunosuppressive therapy in lung transplantation.

Curr Pharm Des 2020 Jun 27. Epub 2020 Jun 27.

Surgery, University of Toronto, Division of Thoracic Surgery, Toronto General Hospital, University Health Network, 200 Elizabeth St 9N969, Toronto ON M5G2C4. Canada.

Long term survival and quality of life after lung transplantation are still affected by the development of chronic lung graft dysfunction (CLAD). CLAD is the number one cause of death one year after transplant; and there is no effective therapy available to date. Transplant centers' approaches include perioperative immunosuppression, maintenance immunosuppression, and the treatment of eventual rejection. Read More

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http://dx.doi.org/10.2174/1381612826666200628023150DOI Listing

Acute Kidney Injury in Patients Undergoing Cardiopulmonary Bypass for Lung Transplantation.

J Surg Res 2020 Jun 26;255:332-338. Epub 2020 Jun 26.

Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Cardiopulmonary bypass (CPB) is often used to support patients undergoing lung transplantation who are intolerant of anatomic manipulation or single lung ventilation during the procedure. However, CPB may be associated with adverse outcomes. We evaluated the hypothesis that CPB is associated with increased acute kidney injury (AKI) and postoperative mortality after lung transplantation. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.072DOI Listing

A multicenter trial of a shared DECision Support Intervention for Patients offered implantable Cardioverter-DEfibrillators: DECIDE-ICD rationale, design, Medicare changes, and pilot data.

Am Heart J 2020 Apr 20;226:161-173. Epub 2020 Apr 20.

Adult and Child Consortium for Outcomes Research and Delivery Science, Aurora, CO; VA Eastern Colorado Geriatric Research Education and Clinical Center, Denver, CO; Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.

Shared decision making (SDM) facilitates delivery of medical therapies that are in alignment with patients' goals and values. Medicare national coverage decision for several interventions now includes SDM mandates, but few have been evaluated in nationwide studies. Based upon a detailed needs assessment with diverse stakeholders, we developed pamphlet and video patient decision aids (PtDAs) for implantable cardioverter/defibrillator (ICD) implantation, ICD replacement, and cardiac resynchronization therapy with defibrillation to help patients contemplate, forecast, and deliberate their options. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.04.010DOI Listing

Chronic rhinosinusitis in patients with cystic fibrosis-Current management and new treatments.

Laryngoscope Investig Otolaryngol 2020 Jun 13;5(3):368-374. Epub 2020 Jun 13.

Department of Otorhinolaryngology Mayo Clinic Rochester Minnesota USA.

Objectives: The purpose of this article is to provide a state-of-the-art review of the literature and summarize the latest publications on medical and surgical treatment of cystic fibrosis (CF) chronic rhinosinusitis (CRS), with an emphasis on describing recent advancements in cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies.

Methods: A comprehensive literature review was conducted utilizing the PubMed database with search phrases detailed within the body of the article. Abstracts were reviewed to include publications detailing medical, surgical, and CFTR modulating therapies for CF CRS. Read More

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http://dx.doi.org/10.1002/lio2.401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314487PMC

First Case of Brucella Pneumonia in a Lung Transplant Patient: Case Report and Review of the Literature.

Cureus 2020 Jun 21;12(6):e8733. Epub 2020 Jun 21.

Organ Transplant, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU.

Brucella is one of the most common zoonotic diseases worldwide. It is endemic in the Mediterranean basin. Brucella pneumonia is a rare complication of brucellosis that can present with a variety of clinical and radiological manifestations. Read More

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http://dx.doi.org/10.7759/cureus.8733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308817PMC

Outcome of Extracorporeal Photopheresis as an Add-On Therapy for Antibody-Mediated Rejection in Lung Transplant Recipients.

Transfus Med Hemother 2020 Jun 5;47(3):205-213. Epub 2020 May 5.

Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Introduction: The diagnosis and treatment of antibody-mediated rejection (AMR) after lung transplantation has recently gained recognition within the transplant community. Extracorporeal photopheresis (ECP), currently used to treat chronic lung allograft dysfunction, modulates various pathways of the immune system known to be involved in AMR. We hypothesize that adding ECP to established AMR treatments could prevent the rebound of donor-specific antibodies (DSA). Read More

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http://dx.doi.org/10.1159/000508170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315205PMC

Comparison of Vancomycin Pharmacokinetics in Cystic Fibrosis Patients Pre and Post-lung Transplant.

Clin Med Insights Circ Respir Pulm Med 2020 15;14:1179548420930925. Epub 2020 Jun 15.

Pharmacy Department, Boston Children's Hospital, Boston, MA, USA.

Background: Vancomycin is commonly used to treat acute cystic fibrosis (CF) exacerbations associated with methicillin-resistant (MRSA). Multiple studies have demonstrated pharmacokinetic differences of antimicrobials in the CF population. Very little data exist regarding pharmacokinetics postlung transplant, but 2 studies have noted changes in tobramycin pharmacokinetics. Read More

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http://dx.doi.org/10.1177/1179548420930925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297476PMC

HERBALIFE® ASSOCIATED SEVERE HEPATOTOXICITY IN A PREVIOUSLY HEALTHY WOMAN.

Acta Clin Croat 2019 Dec;58(4):771-776

1Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 2Department of Gastroenterology and Hepatology, Sveti Duh University Hospital, Zagreb, Croatia; 3Faculty of Health Studies, University of Rijeka, Rijeka, Croatia; 4Department of Endocrinology, Diabetes and Metabolic Diseases, Sveti Duh University Hospital, Zagreb, Croatia; 5Jordanovac Hospital for Lung Diseases, Zagreb University Hospital Centre, Zagreb, Croatia.

Lately there has been an increased consumption of herbal preparations, distributed as nutritional supplements, often claimed to be 'natural' and harmless. However, as their use is not subjected to strict pre-marketing testing and regulations, their ingredients are not clearly defined and there is no quality control or proof of their effectiveness and safety. A growing body of references accentuate their harmful effects, in particular hepatotoxicity, which varies from minimal hepatogram changes to fulminant hepatitis requiring liver transplantation. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314303PMC
December 2019

Why is SARS-CoV-2 infection more severe in obese men? The gut lymphatics - Lung axis hypothesis.

Med Hypotheses 2020 Jun 23;144:110023. Epub 2020 Jun 23.

Department of Gastroenterology, IBD and Nutritional Support, CHU Paris Nord-Val de Seine, Beaujon Hospital, Clichy, France.

Consistent observations report increased severity of SARS-CoV-2 infection in overweight men with cardiovascular factors. As the visceral fat possesses an intense immune activity, is involved in metabolic syndrome and is at the crossroad between the intestines, the systemic circulation and the lung, we hypothesized that it plays a major role in severe forms of SARS-CoV-2 infection. SARS-CoV2 presents the ability to infect epithelial cells of the respiratory tract as well as the intestinal tract. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.110023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308746PMC

Immune modulation via T regulatory cell enhancement: disease-modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases - An EAACI position paper of the Task Force on Immunopharmacology (TIPCO).

Allergy 2020 Jun 27. Epub 2020 Jun 27.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

Therapeutic advances using targeted biologicals and small molecule drugs have achieved significant success in the treatment of chronic allergic, autoimmune and inflammatory diseases particularly for some patients with severe, treatment-resistant forms. This has been aided by improved identification of disease phenotypes. Despite these achievements, not all severe forms of chronic inflammatory and autoimmune diseases are successfully targeted, and current treatment options, besides allergen immunotherapy for selected allergic diseases, fail to change the disease course. Read More

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http://dx.doi.org/10.1111/all.14478DOI Listing

Comparison of reduced-toxicity conditioning protocols using fludarabine, melphalan combined with thiotepa or carmustine in allogeneic hematopoietic cell transplantation.

Bone Marrow Transplant 2020 Jun 26. Epub 2020 Jun 26.

Department of Hematology/Oncology/Stem Cell Transplantation, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.

The age of patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) has increased during the last decades, mainly due to improved reduced-intensity/toxicity conditioning protocols. A reduced-intensity conditioning based on fludarabin, carmustin/BCNU and melphalan (FBM) has been previously developed at our institution. Since we observed detrimental effects in individual patients with compromised lung function, efforts have been made in order to replace BCNU by thiotepa (FTM) to reduce toxicity. Read More

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http://dx.doi.org/10.1038/s41409-020-0986-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319212PMC

Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice.

Redox Biol 2020 Jun 17:101609. Epub 2020 Jun 17.

Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, 29209, USA. Electronic address:

Tristetraprolin (TTP), an mRNA binding and decaying protein, plays a significant role in controlling inflammation by decaying mRNAs encoding inflammatory cytokines such as TNFalpha. We aimed to test a hypothesis that TTP in bone marrow (BM) cells regulates atherogenesis by modulating inflammation and lipid metabolism through the modulation of oxidative stress pathways by TTP target genes. In a BM transplantation study, lethally irradiated atherogenic LDLR mice were reconstituted with BM cells from either wild type (TTP) or TTP knockout (TTP) mice, and fed a Western diet for 12 weeks. Read More

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http://dx.doi.org/10.1016/j.redox.2020.101609DOI Listing

Study design of the DAS-OLT trial: a randomized controlled trial to evaluate the impact of dexmedetomidine on early allograft dysfunction following liver transplantation.

Trials 2020 Jun 26;21(1):582. Epub 2020 Jun 26.

Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK.

Background: Perioperative ischemia/reperfusion (I/R) injury during liver transplantation is strongly associated with early allograft dysfunction (EAD), graft loss, and mortality. Hepatic I/R injury also causes remote damage to other organs including the renal and pulmonary systems. Dexmedetomidine (DEX), a selective α2-adrenoceptor agonist which is used as an adjuvant to general anesthesia, has been shown in preclinical studies to provide organ protection by ameliorating the effects of I/R injury in a range of tissues (including the liver). Read More

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http://dx.doi.org/10.1186/s13063-020-04497-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317895PMC
June 2020
2.117 Impact Factor

Primary pulmonary extranodal natural killer/T-cell lymphoma (ENKTL), nasal type: Two case reports and literature review.

Medicine (Baltimore) 2020 Jun;99(26):e20822

Department of Cardio-Thoracic Surgery, Shenzhen University General Hospital.

Introduction: Extranodal natural killer/T-cell lymphoma (ENKTL) - nasal type is an aggressive form of malignant non-Hodgkin lymphoma with a very poor prognosis. Especially primary pulmonary ENKTL is a relatively rare form of non-Hodgkin lymphoma. Until now, the prevalence of primary pulmonary ENKTL is unknown. Read More

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http://dx.doi.org/10.1097/MD.0000000000020822DOI Listing

Human Lungs Airway Epithelium Upregulate MicroRNA-17 and MicroRNA-548b in Response to Cold Ischemia and Ex Vivo Reperfusion.

Transplantation 2020 Jun 23. Epub 2020 Jun 23.

Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.

Background: Lung ischemia-reperfusion injury (IRI) after transplantation is associated with worse clinical outcomes. MicroRNA (miR) are critical regulators of gene expression that could provide potential targets for novel gene therapy. Herein, we aim to examine the feasibility of using the ex vivo lung perfusion (EVLP) platform to examine the changes in miR expression in human lungs in response to cold ischemia and ex vivo reperfusion (CI/EVR). Read More

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http://dx.doi.org/10.1097/TP.0000000000003370DOI Listing