44,325 results match your criteria Lung Transplantation


Size Mismatching Increases Mortality Following Lung Transplantation in Pre-Adolescent Patients.

Ann Thorac Surg 2019 Feb 11. Epub 2019 Feb 11.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

Background: The impact of size mismatch between donor and recipient in pediatric lung transplantation (PLTx) is currently unknown. Previous studies in adults have suggested that oversized allografts are associated with improved outcomes following lung transplantation. We investigated this relationship in order to quantify its effect on post-transplant outcomes in children. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.015DOI Listing
February 2019

Association between Allosensitization and Waiting List Outcomes among Adult Lung Transplant Candidates in the United States.

Ann Am Thorac Soc 2019 Feb 14. Epub 2019 Feb 14.

Washington University in Saint Louis School of Medicine, 12275, Pulmonary & Critical Care, Saint Louis, Missouri, United States.

Rationale: Allosensitization may be a barrier to lung transplantation. Currently, consideration is not given to allosensitization when assigning priority on the lung transplant waiting list.

Objective: We aimed to examine the association between allosensitization and waitlist outcomes. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201810-713OCDOI Listing
February 2019

Characteristics of CF-related Diabetes: Data from Two Different Sources the ECFS Patient Registry and the DPV Registry.

Pediatr Diabetes 2019 Feb 13. Epub 2019 Feb 13.

Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, 89081 Ulm, Germany.

Background: Standardized patient registries provide a unique basis to get insight into cystic fibrosis-related diabetes (CFRD), the most common comorbidity in cystic fibrosis.

Methods: 3,853 CFRD patients from the European CF Society Patient Registry (ECFSPR) and 752 from the German/Austrian diabetes prospective follow-up (DPV) were studied. To adjust for age and sex, multivariable regression was used (SAS 9. Read More

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http://dx.doi.org/10.1111/pedi.12831DOI Listing
February 2019

Butyrate Attenuates Lung Inflammation by Negatively Modulating Th9 Cells.

Front Immunol 2019 29;10:67. Epub 2019 Jan 29.

Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Th9 cells orchestrate allergic lung inflammation by promoting recruitment and activation of eosinophils and mast cells, and by stimulating epithelial mucus production, which is known to be mainly dependent on IL-9. These cells share developmental pathways with induced regulatory T cells that may determine the generation of one over the other subset. In fact, the FOXP3 transcription factor has been shown to bind locus and repress IL-9 production. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361737PMC
January 2019

Multidrug-Resistant Accelerate Intestinal, Extra-Intestinal, and Systemic Inflammatory Responses in Human Microbiota-Associated Mice With Subacute Ileitis.

Front Immunol 2019 29;10:49. Epub 2019 Jan 29.

Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Berlin Institute of Health, Charité - University Medicine Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

The globally rising incidences of multidrug-resistant (MDR) (Psae) in humans and live-stock animals has prompted the World Health Organization to rate MDR Psae as serious threat for human health. Only little is known, however, regarding factors facilitating gastrointestinal Psae-acquisition by the vertebrate host and subsequently induced inflammatory sequelae. In the present study, we addressed whether subacute ileitis predisposed mice harboring a human gut microbiota for intestinal MDR Psae carriage and whether inflammatory responses might be induced following peroral challenge with the opportunistic pathogen. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361842PMC
January 2019

Patients Treated for Central Airway Stenosis After Lung Transplantation Have Persistent Airflow Limitation.

Ann Transplant 2019 Feb 14;24:84-92. Epub 2019 Feb 14.

Department of Respiratory Medicine, Federation of Translational Medicine of Strasbourg (FMTS), University Hospitals, Strasbourg, France.

BACKGROUND Although central airway stenosis (CAS) is a common complication after lung transplantation, its consequences have been poorly evaluated. The objective of our study was to evaluate the impact of CAS on lung function after lung transplantation. MATERIAL AND METHODS All lung transplant recipients from June 2009 to August 2014 in a single center (Strasbourg, France) were retrospectively reviewed. Read More

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http://dx.doi.org/10.12659/AOT.911923DOI Listing
February 2019

Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer.

Sci Transl Med 2019 Feb;11(479)

Division of Thoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.

Data from mouse tumor models suggest that tumor-associated monocyte/macrophage lineage cells (MMLCs) dampen antitumor immune responses. However, given the fundamental differences between mice and humans in tumor evolution, genetic heterogeneity, and immunity, the function of MMLCs might be different in human tumors, especially during early stages of disease. Here, we studied MMLCs in early-stage human lung tumors and found that they consist of a mixture of classical tissue monocytes and tumor-associated macrophages (TAMs). Read More

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http://dx.doi.org/10.1126/scitranslmed.aat1500DOI Listing
February 2019

Lung Ultrasound B-lines Occurrence in Relation to Left Ventricular Function and Hydration Status in Hemodialysis Patients.

Medicina (Kaunas) 2019 Feb 12;55(2). Epub 2019 Feb 12.

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, 40-027 Katowice, Poland.

Background And Objective: Reliable assessment of the fluid status in hemodialysis (HD) patients is often difficult. A lung ultrasound with an assessment of the B-lines ("lung comets" (LCs)) number is a novel hydration status measure. However, the occurrence of left ventricular dysfunction may have a significant effect on pulmonary congestion and further modulate the LC number. Read More

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http://dx.doi.org/10.3390/medicina55020045DOI Listing
February 2019

Dysfunction of Airway Basal Progenitors Can Be Rescued by a Healthy Microenvironment. Implications in Regenerative Therapy.

Ann Am Thorac Soc 2018 Dec;15(Supplement_4):S287-S288

1 National Jewish Health, Denver, Colorado.

Rationale: Airway basal progenitor cells are critical for maintenance and repair of the epithelium after injury, because they can renew themselves and differentiate into all cell types that make up a normal airway. We have shown that these functions of progenitors are significantly impaired in smoking-induced lung diseases, such as chronic obstructive pulmonary disease and airway premalignancy. Interestingly, progenitors isolated from the diseased airways mimic the in vivo histology after differentiation in vitro at the air-liquid interface (ALI). Read More

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http://dx.doi.org/10.1513/AnnalsATS.201808-563MGDOI Listing
December 2018

Pirfenidone Therapy for Familial Pulmonary Fibrosis: A Real-Life Study.

Lung 2019 Feb 13. Epub 2019 Feb 13.

Respiratory Diseases and Lung Transplantation Unit, Azienda Ospedaliera Universitaria Senese (AOUS) - Department of Medical and Surgical Sciences & Neurosciences, University of Siena, Viale Bracci, 16, 53100, Siena, Italy.

Introduction: Familial pulmonary fibrosis (FPF) is defined as an idiopathic diffuse parenchymal lung disease affecting two or more members of the same primary biological family. The aim of this study was to compare disease progression and tolerance to pirfenidone in a population of FPF patients who presented with radiological and/or histological evidence of UIP, and a group of idiopathic pulmonary fibrosis (IPF) patients.

Methods: Seventy-three patients (19 with FPF and 54 with IPF) were enrolled and data were collected retrospectively at 6, 12 and 24 months follow-up. Read More

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http://dx.doi.org/10.1007/s00408-019-00203-wDOI Listing
February 2019

Unintended Consequences of Changes to Lung Allocation Policy.

Am J Transplant 2019 Feb 13. Epub 2019 Feb 13.

Division of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.

Organ allocation for transplantation aims to balance the principles of justice and medical utility to optimally utilize a scarce resource. To address practical considerations, the U.S. Read More

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http://dx.doi.org/10.1111/ajt.15307DOI Listing
February 2019

Life-Saving Combined Heart-Kidney Transplantation in a Previous Sequential Heart and Kidney Transplant Recipient.

Eur J Case Rep Intern Med 2018 28;5(8):000924. Epub 2018 Aug 28.

Department of Nephrology, St Vincent's Hospital Sydney, New South Wales, Australia.

Purpose: Solid organ re-transplantation in the context of allograft failure is a challenging clinical and ethical problem. Ideally, solid organ re-transplantation after initial allograft failure should be performed in all recipients, but this is often not clinically or logistically feasible.

Methods: This report details what we believe is the first combined heart-kidney transplant in a recipient of a previous sequential heart and kidney transplant. Read More

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http://dx.doi.org/10.12890/2018_000924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346832PMC

A Case of Donor-Transmitted Non-Small Cell Lung Cancer After Liver Transplantation: An Unwelcome Guest.

Oncologist 2019 Feb 12. Epub 2019 Feb 12.

Mayo Clinic Cancer Center, Phoenix, Arizona, USA

Cancer transmission with organ donation has been previously reported with a variety of malignancies and organ transplants. The risk of transmission through organ transplantation from donors with a history of previously treated malignancies has been addressed by guidelines from transplant societies. Herein, we report a case of a patient who developed lung cancer confined to the liver after liver transplantation with no known history of malignancy in the donor. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0517DOI Listing
February 2019

'When you hear hooves, think zebras, not horses'; two challenging cases of interstitial lung disease (ILD).

BMJ Case Rep 2019 Feb 11;12(2). Epub 2019 Feb 11.

Department of Respiratory Medicine, St Vincent's University Hospital, Dublin, Ireland.

Our case series describes two siblings with complex fibrosing lung diseases. The first patient was initially given a diagnosis of sarcoidosis based on imaging and exclusion of alternative diagnoses. A number of years after diagnosis, he had rapid deterioration of his disease and following surgical lung biopsy, his lung fibrosis was re-classified as chronic hypersensitivity pneumonitis (cHP) with a usual interstitial pneumonia pattern. Read More

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http://dx.doi.org/10.1136/bcr-2018-224507DOI Listing
February 2019

Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells.

J Exp Clin Cancer Res 2019 Feb 12;38(1):71. Epub 2019 Feb 12.

Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.

Background: The efficacy and safety of multikinase inhibitor anlotinib have been confirmed in the treatment of advanced non-small cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality mediated by anlotinib were not fully elucidated, and the underlying mechanisms related to resistance remain largely elusive.

Methods: Cell viability, colony formation, apoptosis and tumor growth assays were performed to examine the effect of anlotinib on lung cancer cells in vitro and in vivo. Read More

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http://dx.doi.org/10.1186/s13046-019-1093-3DOI Listing
February 2019

Wine cup stoma anastomosis after extended sleeve lobectomy for central-type squamous cell lung cancer.

J Cardiothorac Surg 2019 Feb 12;14(1):36. Epub 2019 Feb 12.

Department of Chest Surgery, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan.

Background: Extended sleeve lobectomy is rarely applied to pulmonary surgery for primary lung cancer to avoid a pneumonectomy. As there is a size discrepancy between main bronchus and peripheral bronchus, ingenuity to improve anastomosis is required in the bronchoplasty. We report herein a case in which successful reconstruction of extended sleeve lobectomy with bronchial wall flap. Read More

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http://dx.doi.org/10.1186/s13019-019-0857-3DOI Listing
February 2019

Use of Aspergillus fumigatus real-time PCR in bronchoalveolar lavage samples (BAL) for diagnosis of invasive aspergillosis, including azole-resistant cases, in high risk haematology patients: the need for a combined use with galactomannan.

Med Mycol 2019 Feb 7. Epub 2019 Feb 7.

Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.

Diagnosis of invasive aspergillosis (IA) is challenging, particularly in high-risk patients with lung lesions other than typical according to 2008-EORTC/MSG criteria. Even if microbiology is positive, they still remain unclassified according to 2008-EORTC/MSG. Quantitative polymerase chain reaction (qPCR) provides new mycological documentation of IA. Read More

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http://dx.doi.org/10.1093/mmy/myz002DOI Listing
February 2019

Equally interchangeable? - How sex and gender affect transplantation.

Transplantation 2019 Feb 4. Epub 2019 Feb 4.

Liver Transplantation & Hepatology Unit, Hospital Universitario La Fe, IIS La Fe, University of Valencia-CIBEReHD, Valencia, Spain.

Organ transplantation as an option to overcome end-stage diseases is common in countries with advanced healthcare systems and is increasingly provided in emerging and developing countries. A review of the literature points to sex- and gender-based inequity in the field with differences reported at each step of the transplant process, including access to a transplantation waiting list, access to transplantation once waitlisted as well as outcome after transplantation. In this review, we summarize the data regarding sex- and gender-based disparity in adult and pediatric kidney, liver, lung, heart and hematopoietic stem-cell transplantation and argue that there are not only biological but also psychological and socio-economic issues that contribute to disparity in the outcome, as well as an inequitable access to transplantation for women and girls. Read More

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http://dx.doi.org/10.1097/TP.0000000000002655DOI Listing
February 2019

Tobacco use after Lung Transplantation: A retrospective analysis of patient characteristics, smoking cessation interventions and cessation success rates.

Transplantation 2019 Feb 4. Epub 2019 Feb 4.

Cantonal Hospital Winterthur, Zurich, Switzerland.

Background: Smoking remains the leading cause of preventable disease and death in the developed world that kills half of all long-term users. Tobacco use after solid organ transplantation is associated with allograft dysfunction, cancer, and reduced overall survival.

Methods: In this single-center, retrospective study, we describe the frequency of tobacco use after lung transplantation (LTx), pre-transplant patient characteristics associated with tobacco use, and the safety, efficacy and outcomes of post-transplant tobacco cessation interventions. Read More

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http://dx.doi.org/10.1097/TP.0000000000002576DOI Listing
February 2019

Chagas Cardiomyopathy in Latin America Review.

Curr Cardiol Rep 2019 Feb 12;21(2). Epub 2019 Feb 12.

Messejana Heart and Lung Hospital Dr. Carlos Alberto Studart Gomes, Av. Frei Cirilo, 3480 Messejana, Fortaleza, CE, 60.846-190, Brazil.

Purpose Of Review: Chagas cardiomyopathy is a major public health disease in Latin America and, due to migration, is becoming a worldwide health and economic burden. This review sought to present the clinical and epidemiological aspects of Chagas cardiomyopathy, as well as some specific features and principles of treatment. We also retrospectively assessed our institutional experience with mechanical circulatory support in refractory heart failure due to Chagas cardiomyopathy over a 10-year period. Read More

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http://dx.doi.org/10.1007/s11886-019-1095-yDOI Listing
February 2019

Fungal epidemiology in cystic fibrosis patients with a special focus on Scedosporium species complex.

Microb Pathog 2019 Feb 8. Epub 2019 Feb 8.

Center of Expertise in Microbiology, Infection Biology and Antimicrobial Pharmacology, Tehran, Iran.

In this present study, for the first time, we evaluated the cystic fibrosis (CF) patients for the Scedosporium species and their antifungal susceptibility against eight antifungal agents. During one-year period, 90 Sputum samples were collected from Iranian CF patients. All samples were evaluated by direct microscopic examination, culture onto four different media including Malt extract agar, Inhibitory mold agar, Brain Heart Infusion and Scedo-Select III. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.009DOI Listing
February 2019

Postoperative respiratory failure in liver transplantation: Risk factors and effect on prognosis.

PLoS One 2019 11;14(2):e0211678. Epub 2019 Feb 11.

Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Postoperative respiratory failure (PRF, namely mechanical ventilation >48 hours) significantly affects morbidity and mortality in liver transplantation (LTx). Previous studies analyzed only one or two categories of PRF risk factors (preoperative, intraoperative or postoperative ones). The aims of this study were to identify PRF predictors, to assess the length of stay (LoS) in ICU and the 90-day survival according to the PRF in LTx patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211678PLOS
February 2019

Correlation between the native lung volume change and postoperative pulmonary function after single lung transplantation for lymphangioleiomyomatosis: Evaluation of lung volume by three-dimensional computed tomography volumetry.

PLoS One 2019 11;14(2):e0210975. Epub 2019 Feb 11.

Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

Purpose: Whereas native lung overinflation has been thought to happen in recipients of single lung transplantation for lymphangioleiomyomatosis because of its increased compliance, there is no study that has reported the details on the change of the native lung volume after single lung transplantation by three-dimensional computed tomography volumetry. The purpose of the present study was to evaluate the lung volume after single lung transplantation for lymphangioleiomyomatosis by three-dimensional computed tomography volumetry and investigate the correlation between the native lung volume change and postoperative pulmonary function.

Methods: We retrospectively reviewed the data of 17 patients who underwent single lung transplantation for lymphangioleiomyomatosis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210975PLOS
February 2019

First Onset Herpesviral Infection and Lung Injury in Allogeneic Hematopoietic Cell Transplantation.

Am J Respir Crit Care Med 2019 Feb 11. Epub 2019 Feb 11.

Univ Michigan, Internal Medicine, Ann Arbor, Michigan, United States ;

Rationale: "Non-infectious" pulmonary complications are significant causes of morbidity and mortality post allogeneic hematopoietic cell transplant. Early onset viral reactivations or infections are common after transplant. Whether the first onset viral infection causes "non-infectious" pulmonary complications is unknown. Read More

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http://dx.doi.org/10.1164/rccm.201809-1635OCDOI Listing
February 2019

Prolonged Cold-Ischemia Induces Necroptotic Cell Death in Ischemia Reperfusion Injury and Contributes to Primary Graft Dysfunction After Lung Transplantation.

Am J Respir Cell Mol Biol 2019 Feb 11. Epub 2019 Feb 11.

University of Pittsburgh, Pittsburgh, Pennsylvania, United States.

Primary graft dysfunction (PGD), a major cause of morbidity after lung transplantation, is linked to ischemia-reperfusion injury (IRI). Other factors such as preceding brain death (BD), hemorrhagic shock (HS), and pre-engraftment lung management are also important. We hypothesized that a multi-hit isogenic mouse model of lung transplantation is more closely linked to PGD than IRI alone. Read More

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http://dx.doi.org/10.1165/rcmb.2018-0207OCDOI Listing
February 2019

Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating Nanog.

Cancer Med 2019 Feb 10. Epub 2019 Feb 10.

Laboratory of Translational Cancer Stem Cell Research, Institute of Life Sciences, Chongqing Medical University, Chongqing, China.

Lung cancer has the highest mortality rate due to late diagnosis and high incidence of metastasis. Cancer stem cells (CSCs) are a subgroup of cancer cells with self-renewal capability similar to that of normal stem cells (NSCs). While CSCs may play an important role in cancer progression, mechanisms underlying CSC self-renewal and the relationship between self-renewal of the NSCs and CSCs remain elusive. Read More

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http://dx.doi.org/10.1002/cam4.1992DOI Listing
February 2019
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Immunosuppression for Lung Transplantation: Current and Future.

Curr Transplant Rep 2018 Sep 13;5(3):212-219. Epub 2018 Jul 13.

William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.

Purpose Of The Review: The number of lung transplantations performed worldwide continues to increase. There is a growing need in these patients for more effective immunosuppressive medications with less toxicity.

Recent Findings: This review article summarizes the recent studies and developments in lung transplant immunosuppression. Read More

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http://dx.doi.org/10.1007/s40472-018-0199-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366648PMC
September 2018

The Amide Local Anesthetic Ropivacaine Attenuates Acute Rejection After Allogeneic Mouse Lung Transplantation.

Lung 2019 Feb 9. Epub 2019 Feb 9.

Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.

Purpose: Acute allograft rejection after lung transplantation remains an unsolved hurdle. The pathogenesis includes an inflammatory response during and after transplantation. Ropivacaine, an amide-linked local anesthetic, has been shown to attenuate lung injury due to its anti-inflammatory effects. Read More

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http://dx.doi.org/10.1007/s00408-019-00197-5DOI Listing
February 2019

Lung transplantation for idiopathic pulmonary fibrosis.

Lancet Respir Med 2019 Feb 6. Epub 2019 Feb 6.

Department of Interstitial Lung Disease, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK.

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a poor prognosis. Lung transplantation is the only intervention shown to increase life expectancy for patients with IPF, but it is associated with disease-specific challenges. In this Review, we discuss the importance of a proactive approach to the management of IPF comorbidities, including gastro-oesophageal reflux, pulmonary hypertension, coronary artery disease, and malignancy. Read More

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http://dx.doi.org/10.1016/S2213-2600(18)30502-2DOI Listing
February 2019
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Breast cancer after multiple myeloma treatment.

Authors:
Ahmet Gulmez

Curr Probl Cancer 2019 Feb 1. Epub 2019 Feb 1.

Inonu Univercity Turgut Ozal Medical Center, Malatya/Türkiye, Malatya, Turkey. Electronic address:

Breast cancer is the most common cancer in women. In addition, it is the second leading cause of death after lung cancer. The prevalence of epidemiological studies in previous studies is 22%-26%. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2019.01.004DOI Listing
February 2019

Coexistence an aberrant right subclavian artery with other congenital anomalies: case report and review of the literature.

Surg Radiol Anat 2019 Feb 8. Epub 2019 Feb 8.

Medical Rehabilitation and Physiotherapy Department, Belarusian State Medical University, Minsk, Belarus.

Aberrant right subclavian artery is the most common aortic arch anomaly that frequently occurs in coexistence with other congenital cardiovascular anomalies. A 32-year-old male patient was hospitalized with ventricular septal defect, chronic heart failure NYHA class III, pulmonary arterial hypertension. Contrast-enhanced multislice computed tomography revealed membranous ventricular septal defect, persistent left superior vena cava, bicuspid aortic valve and aberrant right subclavian artery. Read More

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http://dx.doi.org/10.1007/s00276-019-02206-xDOI Listing
February 2019
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Lung Allocation Score System: First Italian Experience.

Transplant Proc 2019 Jan - Feb;51(1):190-193. Epub 2018 Jun 30.

Thoracic Surgery and Lung Transplantation Unit, Ca' Granda Foundation Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

Background: Lung transplantation is an established therapeutic option for patients with end-stage pulmonary disease. In May 2005, the lung allocation score (LAS) was introduced in the United States to maximize the benefit to the recipient population and reduce waiting list mortality. The LAS has been applied in a region of Italy since March 2016 on a provisional basis. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.214DOI Listing

Biofabrication of a vascularized islet organ for type 1 diabetes.

Biomaterials 2019 Jan 24;199:40-51. Epub 2019 Jan 24.

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

Islet transplantation is superior to extrinsic insulin supplementation in the treating severe Type 1 diabetes. However, its efficiency and longevity are limited by substantial islet loss post-transplantation due to lack of engraftment and vascular supply. To overcome these limitations, we developed a novel approach to bio-fabricate functional, vascularized islet organs (VIOs) ex vivo. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.035DOI Listing
January 2019
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Double-lung versus heart-lung transplantation for pre-capillary pulmonary arterial hypertension; A 24-year single-center retrospective study.

Transpl Int 2019 Feb 8. Epub 2019 Feb 8.

Departments of Thoracic Surgery University Hospitals Leuven, Leuven, Belgium.

Background: Transplant type for end-stage pulmonary vascular disease remains debatable. We compared recipient outcome after heart-lung(HLT) versus double-lung(DLT) transplantation.

Methods: Single-center analysis (38HLT-30DLT; 1991-2014] for different causes of pre-capillary pulmonary hypertension(PH): idiopathic(22); heritable(2); drug-induced(9); hepato-portal(1); connective tissue disease(4); congenital heart disease(CHD)(24); chronic thromboembolic PH(6). Read More

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http://dx.doi.org/10.1111/tri.13409DOI Listing
February 2019
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Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression.

J Vis Exp 2019 Jan 19(143). Epub 2019 Jan 19.

Department of Physiology, Center of Physiology and Pharmacology & Comprehensive Cancer Center (CCC), Medical University of Vienna; Ludwig Boltzmann Institute for Cancer Research (LBI-CR).

The use of mouse models is indispensable for studying the pathophysiology of various diseases. With respect to lung cancer, several models are available, including genetically engineered models as well as transplantation models. However, genetically engineered mouse models are time-consuming and expensive, whereas some orthotopic transplantation models are difficult to reproduce. Read More

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https://www.jove.com/video/58101/orthotopic-transplantation-
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http://dx.doi.org/10.3791/58101DOI Listing
January 2019
2 Reads

Recent Advances in Pathology: The 2019 Annual Review Issue of the Journal of Pathology.

J Pathol 2019 Feb 8. Epub 2019 Feb 8.

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

In this Annual Review Issue of The Journal of Pathology, we present 15 invited reviews on topical aspects of pathology, ranging from the impacts of the microbiome in human disease through mechanisms of cell death and autophagy to recent advances in immunity and the uses of genomics for understanding, classifying and treating human cancers. Each of the reviews is authored by experts in their fields and our intention is to provide comprehensive updates in specific areas of pathology in which there has been considerable recent progress. Read More

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http://doi.wiley.com/10.1002/path.5255
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http://dx.doi.org/10.1002/path.5255DOI Listing
February 2019
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Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry.

J Heart Lung Transplant 2019 Jan 17. Epub 2019 Jan 17.

James and John Kirklin Institute for Research in Surgical Outcomes (KIRSO), University of Alabama, Birmingham, Alabama.

Background: Despite advances in device technology and treatment strategies, infection remains a major cause of adverse events (AEs) in mechanical circulatory support (MCS) patients. To characterize the epidemiology of MCS infection, we examined the type, location, and timing of infection in the International Society for Heart and Lung Transplantation Registry (ISHLT) for Mechanically Assisted Circulatory Support (IMACS) over 3 years, 2013 to 2015.

Methods: Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) definitions were used to categorize AE infections occurring in MCS patients within IMACS. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.007DOI Listing
January 2019
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Outcomes in cystic fibrosis lung transplant recipients infected with organisms labeled aspan-resistant: An ISHLT Registry‒based analysis.

J Heart Lung Transplant 2019 Jan 25. Epub 2019 Jan 25.

Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California, USA. Electronic address:

Background: The presence of pan-resistant organisms in patients with cystic fibrosis (CF) potentially impacts mortality after lung transplant (LT). In this study we aimed to study LT mortality in CF patients with and without pan-resistant infection.

Methods: The International Society for Heart and Lung Transplantation (ISHLT) Thoracic Transplant Registry was used to identify adults with CF, first-time, bilateral LT from 1991 to 2015. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1306DOI Listing
January 2019
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Current Use and Impact on 30-Day Mortality of Pulmonary Artery Catheter in Cardiogenic Shock Patients: Results From the CardShock Study.

J Intensive Care Med 2019 Feb 7:885066619828959. Epub 2019 Feb 7.

12 Critical Care Department, Hospital Sant Joan Despi Moisès Broggi, Consorci Sanitari Integral, University of Barcelona, Barcelona, Spain.

Background:: Cardiogenic shock (CS) is the most life-threatening manifestation of acute heart failure. Its complexity and high in-hospital mortality may justify the need for invasive monitoring with a pulmonary artery catheter (PAC).

Methods:: Patients with CS included in the CardShock Study, an observational, prospective, multicenter, European registry, were analyzed, aiming to describe the real-world use of PAC, evaluate its impact on 30-day mortality, and the ability of different hemodynamic parameters to predict outcomes. Read More

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http://dx.doi.org/10.1177/0885066619828959DOI Listing
February 2019
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Jejuno-jejunal intussusception in a post-lung transplant patient from a gastrojejunostomy tube: A case report.

Int J Surg Case Rep 2019 Jan 31;55:129-131. Epub 2019 Jan 31.

Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States. Electronic address:

Introduction: Gastro-jejunostomy tube is used for post-pyloric feeding for critical-ill patient who cannot tolerate oral alimentation. Jejuno-jejunal intussusception is a rare complication of gastrojejunostomy tube.

Presentation Of Case: A 39-year-old male with history of severe combined immunodeficiency, Achalasia and end-stage lung disease underwent double lung transplantation. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.034DOI Listing
January 2019
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Treatment of aggressive non-Hodgkin's lymphoma in frail patients: cardiac comorbidities and advanced age.

Future Oncol 2019 Feb 7. Epub 2019 Feb 7.

Hematology, Azienda USL IRCCS Reggio Emilia, Italy.

The decisive factor in selecting a treatment regimen for a frail patient with aggressive non-Hodgkin's lymphoma is identifying whether a patient is fit enough to tolerate curative-intent anthracycline-containing regimens or too frail and therefore at risk of being undertreated. As cardiac comorbidities are an important contributor to both the health status and the selection of treatment, cardiovascular profiling and baseline risk stratification prior to treatment should be considered. Comprehensive geriatric assessment is an efficient means of identifying elderly patients with non-Hodgkin's lymphoma who may benefit from a curative treatment approach. Read More

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http://dx.doi.org/10.2217/fon-2019-0019DOI Listing
February 2019
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Bronchiolitis obliterans syndrome 'endotypes' in haematopoietic stem cell transplantation.

Respirology 2019 Feb 7. Epub 2019 Feb 7.

Queensland Lung Transplant Program, The Prince Charles Hospital, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1111/resp.13498DOI Listing
February 2019
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Effect of terlipressin infusion therapy on recipient's hepatic and renal functions in living donor liver transplantations: Experience from a tertiary hospital.

Niger J Clin Pract 2019 Feb;22(2):265-269

Department of General Surgery - Organ Transplantation Center, Istanbul Medipol University, Istanbul, Turkey.

Background: Patients with end-stage liver disease are prone to hemodynamic disturbances which may be aggravated with liver transplantation. Blood pooling in splanchnic area and portal hypertension cause reduction in central blood volume. Terlipressin reduces mesenteric and hepatic blood flow, causing vasoconstriction in the smooth muscles of the arteries in the splanchnic region. Read More

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http://dx.doi.org/10.4103/njcp.njcp_268_17DOI Listing
February 2019
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Childhood, adolescent and young adult non-Hodgkin lymphoma: current perspectives.

Br J Haematol 2019 Feb 6. Epub 2019 Feb 6.

Division of Paediatric Haemato-Oncology, Princess Maxima Centre for Paediatric Oncology, Utrecht, The Netherlands.

The 6th International Symposium on Childhood, Adolescent and Young Adult (CAYA) Non-Hodgkin Lymphoma (NHL) was held in Rotterdam, Netherlands, 26-29 September, 2018. This summary manuscript is a perspective on the presentations from the plenary scientific sessions, including wellness and survivorship, B-cell NHL, AYA lymphoma, translational NHL biology, lymphoma immunology, bone marrow transplantation and cell therapy, T/Natural Killer cell lymphoma, anaplastic large cell lymphoma, lymphoblastic lymphoma, novel lymphoma therapeutics and Hodgkin lymphoma. The symposium was attended by over 260 registrants from 42 different countries and included young, middle and senior investigators. Read More

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http://dx.doi.org/10.1111/bjh.15764DOI Listing
February 2019
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Inhibition of B cell-dependent lymphoid follicle formation prevents lymphocytic bronchiolitis after lung transplantation.

JCI Insight 2019 02 7;4(3). Epub 2019 Feb 7.

Comprehensive Pneumology Center, Member of the German Center for Lung Research, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Ludwig-Maximilians University Munich, Munich Germany.

Lung transplantation (LTx) is the only therapeutic option for many patients with chronic lung disease. However, long-term survival after LTx is severely compromised by chronic rejection (chronic lung allograft dysfunction [CLAD]), which affects 50% of recipients after 5 years. The underlying mechanisms for CLAD are poorly understood, largely due to a lack of clinically relevant animal models, but lymphocytic bronchiolitis is an early sign of CLAD. Read More

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http://dx.doi.org/10.1172/jci.insight.123971DOI Listing
February 2019
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Myeloid cells require gp130 signaling for protective anti-inflammatory functions during sepsis.

FASEB J 2019 Feb 6:fj201802118R. Epub 2019 Feb 6.

Department of Internal Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany.

Sepsis represents a major health problem worldwide because of high mortality rates and cost-intensive therapy. Immunomodulatory strategies as a means of controlling overshooting inflammatory responses during sepsis have thus far not been effective, and there is a general paucity of new therapies. Regulatory immune cells have been shown to play important roles in limiting systemic inflammation. Read More

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http://dx.doi.org/10.1096/fj.201802118RDOI Listing
February 2019

Variation in Nonmelanoma Skin Cancer Incidence by Treatment Modality Among Patients Receiving Multiple Kidney Transplants.

JAMA Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Nephrology and Kidney Transplantation, Beaumont Hospital Dublin, Ireland.

Importance: Existing data suggest that nonmelanoma skin cancer (NMSC) is more common in renal transplant recipients than in maintenance dialysis patients. However, whether the risk of NMSC varies as the treatment modality for end-stage kidney disease (ESKD) changes between dialysis and transplantation is not well described.

Objective: To determine whether the incidence of NMSC is attenuated during periods of graft loss with a return to dialysis in those who receive multiple kidney transplants. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4660DOI Listing
February 2019
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Alpha-1 Antitrypsin Substitution for Extrapulmonary Conditions in Alpha-1 Antitrypsin Deficient Patients.

Chronic Obstr Pulm Dis 2018 Sep 19;5(4):267-276. Epub 2018 Sep 19.

Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder which most commonly manifests as pulmonary emphysema. Accordingly, alpha-1 antitrypsin (AAT) augmentation therapy aims to reduce the progression of emphysema, as achieved by life-long weekly slow-drip infusions of plasma-derived affinity-purified human AAT. However, not all AATD patients will receive this therapy, due to either lack of medical coverage or low patient compliance. Read More

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http://dx.doi.org/10.15326/jcopdf.5.4.2017.0161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361480PMC
September 2018
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Endobronchial fusariosis in a child following bilateral lung transplant.

Med Mycol Case Rep 2019 Mar 14;23:77-80. Epub 2019 Jan 14.

Infectious Diseases and Microbiology, The Children's Hospital at Westmead, Sydney, Australia.

We present a case of endobronchial fusariosis following bilateral sequential lung transplantation for idiopathic pulmonary arterial hypertension in a 13 years old boy who was treated successfully with posaconazole and nebulized amphotericin B. We discuss the role of nebulized amphotericin B in treating invasive pulmonary fungal disease in children. To our knowledge, this is the first pediatric case of endobronchial fusariosis reported in the literature. Read More

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http://dx.doi.org/10.1016/j.mmcr.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352292PMC