66,026 results match your criteria Lung Metastases

Performance of the EarlyCDT® Lung test in detection of lung cancer and pulmonary metastases in a high-risk cohort.

Lung Cancer 2021 Jun 10;158:85-90. Epub 2021 Jun 10.

Institute of Regional Health Research, University of Southern Denmark, J.B. Winsløws Vej 19, 3, 5000 Odense C, Denmark; Department of Internal Medicine, Vejle Hospital, University Hospital of Southern Denmark, Beriderbakken 4, 7100 Vejle, Denmark. Electronic address:

Objectives: Early detection of lung cancer is pivotal for an optimal prognosis. CT screening is currently implemented in USA. To decrease the amount of CT scans, the application of a blood-based biomarker as part of screening criteria is desirable. Read More

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Carcinomatous meningitis from recurrent glassy cell carcinoma of the uterine cervix-A case report.

J Obstet Gynaecol Res 2021 Jun 14. Epub 2021 Jun 14.

Department of Obstetrics and Gynecology, St. Mary's Hospital, Kurume, Japan.

Carcinomatous meningitis presents with a variety of neurological symptoms and has a poor prognosis. We encountered a case of carcinomatous meningitis from cervical cancer. A 30-year-old patient was diagnosed with cervical cancer (glassy cell carcinoma), stage IIB. Read More

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EGFR Exon 20 Insertion Mutations: Clinicopathological Characteristics and Treatment Outcomes in Advanced Non-Small Cell Lung Cancer.

Clin Lung Cancer 2021 May 16. Epub 2021 May 16.

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia. Electronic address:

Background: Epidermal growth factor receptor gene (EGFR) exon 20 insertion (ex20-ins) mutations are an uncommon and heterogeneous group of non-small cell lung cancers (NSCLCs), resistant to conventional EGFR tyrosine kinase inhibitors (TKIs). Characteristics and outcomes of patients with EGFR ex20-ins have not been fully established; we sought to clarify them using a multinational patient database.

Patients And Methods: Patients with NSCLC from six Australian institutions with EGFR exon 20 mutations (ex20-mut), excluding T790M, were retrospectively reviewed. Read More

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[Complete Remission of Metastatic Renal Cell Carcinoma with Invasion of the Duodenum and Pancreas after Treatment with Nivolumab Plus Ipilimumab Followed by Axitinib and Surgery : A Case Report].

Hinyokika Kiyo 2021 May;67(5):197-203

The Department of Urology, Kyoto University Hospital.

A man in his 60s was diagnosed with clear cell carcinoma of the right kidney with multiple lung metastases, tumor thrombus of the inferior vena cava (IVC), and invasion of the duodenum and pancreas. Ipilimumab plus nivolumab was administered as first-line therapy. After 3 treatment courses, computed tomography (CT) demonstrated a slight decrease in the size of the primary tumor and lung metastases. Read More

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Efficacy and safety of treatment modalities across EGFR selected/unselected populations with non-small cell lung cancer and brain metastases: A systematic review and Bayesian network meta-analysis.

Lung Cancer 2021 Feb 27;158:74-84. Epub 2021 Feb 27.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China; State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address:

Objective: To compare the efficacy and safety of treatment modalities across different populations with non-small cell lung cancer and brain metastases.

Methods: A comprehensive search for randomized controlled trials was conducted in databases including PubMed, Embase, the Cochrane library, the ClinicalTrials.gov, and major international conferences. Read More

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February 2021

Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs.

Nat Cancer 2020 Jun 25;1(6):603-619. Epub 2020 May 25.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104; USA.

Primary tumor-derived factors (TDFs) act upon normal cells to generate a pre-metastatic niche, which promotes colonization of target organs by disseminated malignant cells. Here we report that TDFs-induced activation of the p38α kinase in lung fibroblasts plays a critical role in the formation of a pre-metastatic niche in the lungs and subsequent pulmonary metastases. Activation of p38α led to inactivation of type I interferon signaling and stimulation of expression of fibroblast activation protein (FAP). Read More

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Case report: multimodality imaging to diagnose cardiac diffuse large B-cell lymphoma.

Eur Heart J Case Rep 2021 May 7;5(5):ytab172. Epub 2021 May 7.

Division of Cardiology, Department of Medicine, McGill University, 1009 rue de Bleury, Apt 1009, Montréal, QC H2Z 0A3, Canada.

Background: Primary cardiac lymphoma (PCL) is rare and can present with a wide variety of clinical symptoms, frequently leading to a delay in diagnosis.

Case Summary: We report a case of a PCL in an 81-year-old man. Cardiac magnetic resonance imaging showed multiple masses in the right atrium and a mass in the right ventricular outflow tract extending to the pulmonary artery. Read More

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Primary Extraosseous Ewing's Sarcoma of the Lung: Radiologic and Pathologic correlation.

Cureus 2021 May 4;13(5):e14830. Epub 2021 May 4.

Pathology, Osmangazi University Faculty of Medicine, Eskisehir, TUR.

Ewing's sarcoma (ES) is a rare and highly aggressive tumor belonging to a family of neoplasms of neuroectodermal origin, which primarily affects the bones or soft tissues. ES originating from lung parenchyma without chest wall involvement is extremely rare with less than 40 cases reported in the English literature. A 41-year-old man admitted to the thoracic surgery department presenting with intermittent non-productive cough, dyspnea, left-sided chest pain for two months for further evaluation and treatment with a preliminary diagnosis of pulmonary mass. Read More

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Enteral lorlatinib after alectinib as a treatment option in anaplastic lymphoma kinase-positive non-small cell lung cancer with triple problems: carcinomatous meningitis, poor performance status, and dysphagia-a case report.

Respirol Case Rep 2021 Jul 3;9(7):e00796. Epub 2021 Jun 3.

Department of Medical Oncology Hirosaki University Graduate School of Medicine Aomori Japan.

Alectinib treatment is effective in patients with anaplastic lymphoma kinase gene rearrangement-positive non-small cell lung cancer (NSCLC; hereafter positive NSCLC) who exhibit central nervous system (CNS) relapse and poor performance status (PS). Lorlatinib treatment is effective upon failure of other ALK inhibitor-based treatments. However, much remains unknown about the efficacy of lorlatinib in patients with positive NSCLC, who have triple problems, carcinomatous meningitis, poor PS, and dysphagia, after alectinib treatment. Read More

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Cetuximab Can Be an Effective and Low-Toxicity Maintenance Treatment Drug in Patients With Metastatic Colorectal Cancer: A Real-World Study of Zhejiang Cancer Hospital.

Front Pharmacol 2021 28;12:632076. Epub 2021 May 28.

Department of Colorectal Medicine, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China.

After initial treatment, maintenance therapy is now commonly used in mCRC patients, which can help patients live longer, have lower side effects, and higher quality of life. The maintenance treatment may include chemotherapy, targeted therapy, or combined with chemotherapy and targeted therapy. But the evidence of cetuximab maintenance is still scant. Read More

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First case of acrometastases to the wrist reported from penile cancer.

J Cancer Res Ther 2021 Apr-Jun;17(2):599-601

Department of Electroradiology, Medical University; Department of Medical Physics, Greater Poland Cancer Centre, Poznan, Poland.

Penile cancer is a rarely diagnosed cancer that affects 0.4%-0.6% of all male population. Read More

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Association between PD-L1 expression and initial brain metastasis in patients with non-small cell lung cancer and its clinical implications.

Thorac Cancer 2021 Jun 13. Epub 2021 Jun 13.

Division of Hemato-oncology, Department of Internal Medicine, Korea University College of Medicine, Korea University Guro Hospital, Seoul, South Korea.

Background: Brain metastases frequently occur in patients with non-small cell lung cancer (NSCLC) resulting in a poor prognosis. Here, we investigated the association between PD-L1 expression and brain metastasis in patients with NSCLC and its clinical significance.

Methods: A total of 270 patients diagnosed with metastatic NSCLC who underwent PD-L1 testing on their tumor tissue between January 2017 and March 2019 were retrospectively reviewed. Read More

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Exploration of spatial distribution of brain metastasis from small cell lung cancer and identification of metastatic risk level of brain regions: a multicenter, retrospective study.

Cancer Imaging 2021 Jun 13;21(1):41. Epub 2021 Jun 13.

Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 88 Keling Road, Suzhou New District, Suzhou, 215163, Jiangsu, China.

Objectives: This study aimed to explore the spatial distribution of brain metastases (BMs) from small cell lung cancer (SCLC) a homogenous sample, and to identify the metastatic risk levels in brain regions.

Methods: T1-enhanced magnetic resonance imaging (MRI) from SCLC patients were retrospectively reviewed from three medical institutions in China. All images were registered to the standard brain template provided by the Montreal Neurological Institute (MNI) 152 database, followed by transformation of the location of all BMs to the space of standard brain. Read More

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Radiation Therapy for Brain Metastases: A Systematic Review.

Pract Radiat Oncol 2021 Jun 9. Epub 2021 Jun 9.

Southern California Evidence-Based Practice Center, RAND Corporation, Santa Monica, California; Southern California Evidence Review Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Purpose: This evidence report synthesizes the available evidence on radiation therapy for brain metastases.

Methods And Materials: The literature search included PubMed, EMBASE, Web of Science, Scopus, CINAHL, clinicaltrials.gov, and published guidelines in July 2020; independently submitted data, expert consultation, and contacting authors. Read More

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Papillary thyroid microcarcinoma with lung metastases: a case report and review of the literature.

Thyroid Res 2021 Jun 11;14(1):15. Epub 2021 Jun 11.

Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Background: Distant metastasis from papillary thyroid microcarcinoma (PTMC) is rare. Here we report a case of PTMC with multiple lung metastases.

Case Presentation: A 64-year-old man presented to our hospital with abdominal pain. Read More

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Multiple Pulmonary Metastases of Recurrent Giant Cell Tumor of Bone with Expression of VEGFR-2 Successfully Controlled by Denosumab and Apatinib: A Case Report and Literature Review.

Cancer Manag Res 2021 3;13:4447-4454. Epub 2021 Jun 3.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.

Giant cell tumor of bone (GCTB) is a rare, benign, but locally aggressive bone tumor. It has a high tendency for local recurrence, which may increase the incidence of lung metastasis. Currently, an optimal treatment strategy has not been established because of the rarity of pulmonary metastatic GCTB. Read More

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Machine learning-based CT radiomics features for the prediction of pulmonary metastasis in osteosarcoma.

Br J Radiol 2021 Jun 11:20201391. Epub 2021 Jun 11.

Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo and Department of Orthopedic surgery, University of Missouri health Care, Columbia, Missouri.

Objective: This study aims to build machine learning-based CT radiomic features to predict patients developing metastasis after osteosarcoma diagnosis.

Methods And Materials: This retrospective study has included 81 patients with a histopathological diagnosis of osteosarcoma. The entire dataset was divided randomly into training (60%) and test sets (40%). Read More

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Trapezial Acrometastasis as the First Presentation of Occult Lung Cancer: A Case Report.

JBJS Case Connect 2021 06 10;11(2). Epub 2021 Jun 10.

Orthopedic Specialists of Central Pennsylvania, Lancaster, Pennsylvania.

Case: Acrometastasis is extremely rare, accounting for 0.1% of all skeletal metastases. Metastases to the carpus are rarer still. Read More

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Metabolic reprograming of antioxidant defense: a precision medicine perspective for radiotherapy of lung cancer?

Biochem Soc Trans 2021 Jun 10. Epub 2021 Jun 10.

Institute of Cell Biology (Cancer Research), University of Duisburg Essen, University Hospital Essen, Essen, Germany.

Radiotherapy plays a key role in the management of lung cancer patients in curative and palliative settings. Traditionally, radiotherapy was either given alone or in combination with surgery, classical cytotoxic chemotherapy, or both. Technical and physical innovations achieved during the last two decades have helped to enhance the accuracy of radiotherapy dose delivery and have facilitated geometric radiotherapy individualization. Read More

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Identification of DNA methylation biomarkers for risk of liver metastasis in early-stage colorectal cancer.

Clin Epigenetics 2021 Jun 9;13(1):126. Epub 2021 Jun 9.

Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Beijing, 100021, China.

Background: Liver metastases can occur even in CRC patients who underwent curative surgery. While evidence suggested that adjuvant chemotherapy can help to reduce the occurrence of liver metastases for certain patients, it is not a recommended routine as the side effects outweigh the potential benefits, especially in Stage II CRC patients. This study aims to construct a model for predicting liver metastasis risk using differential methylation signals in primary CRC tumors, which can facilitate the decision for adjuvant chemotherapy. Read More

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Characterizing Health-Related Quality of Life by Ambulatory Status in Patients With Spinal Metastases.

Spine (Phila Pa 1976) 2021 Jun 8. Epub 2021 Jun 8.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 Department of Orthopaedic Surgery, NYU Langone Medical Center, New York University, Westbury, NY 11590.

Study Design: Retrospective review of prospective longitudinal data.

Objective: To determine health-related quality of life (HRQL) utilities associated with specific ambulatory states in patients with spinal metastases: independent, ambulatory with assistance and non-ambulatory.

Summary Of Background Data: It is assumed that HRQL is aligned with ambulatory ability in patients with spinal metastases. Read More

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Novel strategy to treat lung metastases: Hybrid therapy involving surgery and radiofrequency ablation.

Thorac Cancer 2021 Jun 9. Epub 2021 Jun 9.

Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Nagoya, Japan.

Background: This study was performed to evaluate the clinical outcomes of hybrid treatment involving surgical resection and percutaneous radiofrequency ablation for patients with multiple lung metastases.

Methods: Seventeen patients (6 men, 11 women; median age, 52 years; range, 16-78 years) underwent hybrid treatment involving surgery and radiofrequency ablation to treat multiple lung metastases (median number, 4; range, 2-26) between May 2014 and February 2020. The primary lesions were colorectal carcinoma (n = 9), uterine endometrial carcinoma (n = 3), osteosarcoma (n = 2), renal cell carcinoma (n = 1), glottic carcinoma (n = 1), and fibrolamellar hepatocellular carcinoma (n = 1). Read More

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Pulmonary sarcoidosis masquerading as metastatic breast cancer: a case report.

Pan Afr Med J 2021 8;38:245. Epub 2021 Mar 8.

Department of Radiology, Alexis Multispecialty Hospital, Nagpur, Maharashtra, India.

Pulmonary lesions on imaging are presumed to be metastatic lesions in patients with breast cancer. Here, we report an interesting case of a 63-year-old lady with breast carcinoma showing pulmonary lesions on imaging suggestive of pulmonary metastases. Detailed evaluation of pulmonary lesions confirmed the presence of co-existing pulmonary sarcoidosis. Read More

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STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR/MAPK signaling pathway.

Neoplasia 2021 Jun 4;23(6):607-623. Epub 2021 Jun 4.

Center for Translational Medicine, The Affiliated Zhangjiagang Hospital of Soochow University, 68 Jiyang West Road, Suzhou, 215600, China; Lead Contact. Electronic address:

Tumor metastasis is a leading cause of death in lung adenocarcinoma (LUAD) patients, but the molecular events that regulate metastasis have not been completely elucidated. STAMBP is a deubiquitinating enzyme of the Jab1/MPN metalloenzyme family that regulates the stability of substrates in cells by specifically removing ubiquitin molecules. We found that STAMBP expression was increased in the cytoplasm of tumor cells from LUAD patients. Read More

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Ribociclib plus fulvestrant for postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer in the phase 3 randomized MONALEESA-3 trial: updated overall survival.

Ann Oncol 2021 May 15. Epub 2021 May 15.

University Hospital Erlangen, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen, Germany.

Background: Ribociclib plus fulvestrant demonstrated significant progression-free survival (PFS) and overall survival (OS) benefits in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC). Here we present a new landmark in survival follow-up for a phase 3 CDK4/6 inhibitor clinical trial in patients with ABC (median [m], 56.3 months). Read More

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Low-grade fibromyxoid sarcoma with pulmonary metastasis. A rare case report.

Rev Med Inst Mex Seguro Soc 2020 04 13;58(2):221-225. Epub 2020 Apr 13.

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Oncología, Servicio de Tumores de Tórax, Ciudad de México, México.

Background: Low-grade fibromyxoid sarcoma is a very rare tumor that tends to develop in deep soft tissues of young adults and has the potential for local recurrence and distant metastasis.

Clinical Case: We present the case of a 36-year-old man with a low-grade fibromyxoid sarcoma in the right shoulder, which was initially reported as a 4-year-old tumor, undergoing extensive resection with a histopathological report of low-grade fibromyxoid sarcoma, whose deep surgical edge was in bony contact. A simple and contrasted axial tomography was performed where an 8 mm left lung lesion was observed in the upper lobe lower lingular segment of heterogeneous content, hyperdense with contrast medium reinforcement. Read More

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Analysis of RAGE Proteome and Interactome in Lung Adenocarcinoma Using PANTHER and STRING Databases.

Charles A Downs

Biol Res Nurs 2021 Jun 7:10998004211021496. Epub 2021 Jun 7.

School of Nursing and Health Studies, University of Miami, Coral Gables, FL, USA.

Adenocarcinoma accounts for about 40% of all lung cancers. Histological studies indicate a loss of expression of the Receptor for Advanced Glycation End-products (RAGE) in lung adenocarcinoma cells compared to neighboring non-malignant tissue. Gene silencing of RAGE in human lung adenocarcinoma cells was performed and then cells were subjected to LC-MS/MS ( = 3, FDR < 1%). Read More

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Durable Response to Immunotherapy With Antiangiogenic Drug in Large-Cell Lung Carcinoma With Multiple Fulminant Postoperative Metastases: A Case Report.

Front Oncol 2021 20;11:633446. Epub 2021 May 20.

Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Immunotherapy alone or chemo-immunotherapy has recently been recommended for treating advanced lung carcinoma in patients without driver mutations. However, the efficacy of immunotherapy and molecular mechanism in large-cell lung cancer (LCLC) remains unclear. Here, we reported a rare case of multiple fulminant postoperative body and mouth metastases in LCLC treating with combination immunotherapy. Read More

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An Elderly Man Suffers a Renal Cell Carcinoma Metastasis in the Pineal Gland: Lessons Learned and Ethical Considerations.

Cureus 2021 Apr 30;13(4):e14771. Epub 2021 Apr 30.

Department of Neurosurgery, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Khobar, SAU.

Metastases to the pineal gland are rare and reported cases have consisted mainly of lung and gastrointestinal primary malignancies. Here we report the third case in the literature of pineal gland metastasis from renal cell carcinoma. A 69-year-old man, status post excision of right renal cell carcinoma 20 years ago, presented with a one-month history of urinary incontinence. Read More

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High concordance of mutation patterns in 10 common mutated genes between tumor tissue and cell-free DNA in metastatic colorectal cancer.

Am J Cancer Res 2021 15;11(5):2228-2237. Epub 2021 May 15.

Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital Taipei, Taiwan.

The concordance of mutation patterns between cell-free DNA (cfDNA) and tumor DNA varies in colorectal cancers (CRCs). Next-generation sequencing (NGS) by targeted sequencing can detect novel genes. We aimed to use NGS to test the concordance between cfDNA and tumor DNA in metastatic CRCs. Read More

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