58,125 results match your criteria Lung Metastases


Local tumor response and survival outcomes after combined stereotactic radiosurgery and immunotherapy in non-small cell lung cancer with brain metastases.

J Neurosurg 2019 Feb 15:1-6. Epub 2019 Feb 15.

1Department of Neurosurgery, Yale New Haven Hospital, New Haven, Connecticut.

OBJECTIVEConcurrent use of anti-PD-1 therapies with stereotactic radiosurgery (SRS) have been shown to be beneficial for survival and local lesional control in melanoma patients with brain metastases. It is not known, however, if immunotherapy (IT) confers the same outcome advantage in lung cancer patients with brain metastases treated with SRS.METHODSThe authors retrospectively reviewed 85 non-small cell lung cancer (NSCLC) patients with brain metastases who were treated with SRS between January 2006 and December 2016. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181371DOI Listing
February 2019

Characterization, prognosis, and treatment of patients with metastatic lung carcinoid tumors.

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Service d'Oncologie Médicale, Groupement Hospitalier Centre, Institut de Cancérologie des Hospices Civils de Lyon, Lyon, France; University of Lyon, Université Lyon 1, France. Electronic address:

Introduction: Metastatic lung carcinoids (MLC) remain poorly characterized and no prognostic stratification exists.

Methods: We conducted a retrospective study including patients with MLC in two European expert centers. The aims were to characterize these, identify prognostic factors of survival, and effectiveness of their treatments. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.02.002DOI Listing
February 2019

Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling cooperation.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. Electronic address:

Rhabdomyosarcoma (RMS) is a pediatric soft tissue tumor classified in two major subtypes namely embryonal and alveolar, which have distinctive histopathological and genetic signatures and worse outcomes in the presence of metastases. Here, in order to evaluate the role of Caveolin-1 (Cav-1) in embryonal RMS dissemination, we employed an experimental in vivo metastasis assay using immunodeficient NOD/SCID mice. We found that the intravenous injection of human RD cells engineered for Cav-1 overexpression promoted the formation of lung metastases compared to parental cells. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.013DOI Listing
February 2019

Current Treatment Options for Breast Cancer Brain Metastases.

Curr Treat Options Oncol 2019 Feb 15;20(3):19. Epub 2019 Feb 15.

Department of Medicine, Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, S73, Cleveland, OH, 44195, USA.

Opinion Statement: In the past, the standard of care for treatment of BM was whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS), and surgery. There has been a greater role for medical therapies in the last two decades due to the discovery of driver mutations and corresponding targeted therapies. These innovations have dramatically altered the approach to treating these patients. Read More

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http://dx.doi.org/10.1007/s11864-019-0618-5DOI Listing
February 2019

Management of patients with brain metastases from non-small cell lung cancer and adverse prognostic features: multi-national radiation treatment recommendations are heterogeneous.

Radiat Oncol 2019 Feb 15;14(1):33. Epub 2019 Feb 15.

Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, USA.

Background: Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over the last decade. It is not trivial to find the optimal balance of over- versus undertreatment in these patients. Several recent trials, including the randomized QUARTZ trial now influence the decision to recommend or withhold WBRT for patients with unfavorable prognosis, and similarly, for favorable prognosis patients, the balance between radiosurgery alone or WBRT has become a nuanced decision. Read More

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http://dx.doi.org/10.1186/s13014-019-1237-9DOI Listing
February 2019

Risk of recurrence and bleeding in patients with cancer-associated venous thromboembolism treated with rivaroxaban: A nationwide cohort study.

Cancer Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.

Background: Rivaroxaban could be an attractive alternative to low molecular weight heparin for the treatment of cancer-associated venous thromboembolism (VTE) but the safety and effectiveness remain unclear. We examined risk of recurrent VTE and major bleeding associated with rivaroxaban treatment of cancer-associated VTE.

Methods: Through linkage of nationwide Danish registries, we identified all adults with cancer-associated VTE initiating treatment with rivaroxaban, 2012-2017. Read More

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http://dx.doi.org/10.1002/cam4.1997DOI Listing
February 2019

[A Case of Metachronous Metastasis to the Pancreas from Ascending Colon Cancer after Subtotal Stomach-Preserving Pancreaticoduodenectomy(SSPPD)].

Gan To Kagaku Ryoho 2019 Jan;46(1):136-138

Dept. of Surgery, Fuchu Hospital.

A67 -year-old man was diagnosed with ascending colon cancer and multiple liver metastases and underwent laparoscopic right hemicolectomy(D3 lymphadenectomy). Pathological examination indicated tubular adenocarcinoma(tub1, pT4apN2H2M1[HEP], pStage Ⅳ). After chemotherapy, he underwent hepatectomy. Read More

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January 2019

[Current Status of Limited Resection for Lung Cancer as Minimally Invasive Surgery].

Kyobu Geka 2019 Jan;72(1):51-56

Division of Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.

This review article describes limited resection for lung cancer based on previous reports and a retrospective examination of the operative results at our hospital.The importance of limited resection as a surgical treatment is becoming much greater than before. In minimally invasive surgery for lung cancer, ① limited resection for pulmonary functional preservation, ② limited resection of lymph node dissection, and ③ minimally invasive thoracic approach may be considered. Read More

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January 2019

Expert consensus on multidisciplinary therapy of colorectal cancer with lung metastases (2019 edition).

J Hematol Oncol 2019 Feb 14;12(1):16. Epub 2019 Feb 14.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No. 52, Fucheng Road, Haidian District, Beijing, 100142, China.

The lungs are the second most common site of metastasis for colorectal cancer (CRC) after the liver. Rectal cancer is associated with a higher incidence of lung metastases compared to colon cancer. In China, the proportion of rectal cancer cases is around 50%, much higher than that in Western countries (nearly 30%). Read More

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http://dx.doi.org/10.1186/s13045-019-0702-0DOI Listing
February 2019
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Clinicopathological characteristics associated with necrosis in pulmonary metastases from colorectal cancer.

Virchows Arch 2019 Feb 14. Epub 2019 Feb 14.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Metastatic lung cancers from the colon and rectum (MLCR) frequently have necrotic components. The aim of this study is to elucidate clinicopathological factors associated with the amount of necrosis in MLCR. Ninety patients who underwent the first pulmonary metastasectomy for MLCR with a tumor diameter ≦ 3. Read More

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http://dx.doi.org/10.1007/s00428-019-02535-7DOI Listing
February 2019

Imaging features of SMARCA4-deficient thoracic sarcomas: a multi-centric study of 21 patients.

Eur Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Institut Bergonié, Comprehensive Cancer Center, 229, cours de l'Argonne, F-33000, Bordeaux, France.

Objectives: SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently identified aggressive subtype of sarcoma. The aim of this study was to characterize the CT imaging features of SMARCA4-DTS.

Methods: From June 2011 to May 2017, 21 adult patients with histologically proven SMARCA4-DTS were identified in the radiological database of 2 French sarcoma reference centers with at least one chest CT scan available. Read More

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http://dx.doi.org/10.1007/s00330-019-06017-xDOI Listing
February 2019
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A Comprehensive Meta-Analysis of Association between EGFR Mutation Status and Brain Metastases in NSCLC.

Pathol Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Oncology Radiotherapy, First Affliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.

Non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation have different clinicopathological characteristics compared with EGFR wild type NSCLC. A growing number of studies focused on the relevance between EGFR mutation status and brain metastases (BM) in NSCLC, but it remains controversial. Therefore, this study performed a comprehensive meta-analysis to untangle this issue. Read More

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http://dx.doi.org/10.1007/s12253-019-00598-0DOI Listing
February 2019
1.806 Impact Factor

Loss of MADD expression inhibits cellular growth and metastasis in anaplastic thyroid cancer.

Cell Death Dis 2019 Feb 13;10(2):145. Epub 2019 Feb 13.

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, 60612, USA.

Anaplastic Thyroid Cancer (ATC) is an aggressive malignancy with limited therapeutic options and dismal patient survival. We have previously shown MADD to be differentially overexpressed in multiple cancer histologies and to contribute to tumor cell growth and survival. Therefore, we targeted MADD by gene silencing, explored its effect on cellular proliferation and metastases and examined its therapeutic potential in an orthotopic ATC model in athymic nude mice. Read More

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http://dx.doi.org/10.1038/s41419-019-1351-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374448PMC
February 2019

The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: a systematic review and meta-analysis.

BMC Cancer 2019 Feb 13;19(1):145. Epub 2019 Feb 13.

Department of Surgical Oncology, First Hospital of China Medical University, Shenyang, 110001, Liaoning Province, China.

Background: The brain is a common site for metastasis in non-small-cell lung cancer (NSCLC). This study was designed to evaluate the relationship between the mutational of the epidermal growth factor receptor (EGFR) and overall survival (OS) in NSCLC patients with brain metastases.

Methods: Searches were performed in PubMed, EmBase, and the Cochrane Library to identify studies evaluating the association of EGFR mutation with OS in NSCLC patients through September 2017. Read More

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http://dx.doi.org/10.1186/s12885-019-5331-zDOI Listing
February 2019
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A case of successfully resected metachronous gastric and gallbladder metastases from pancreatic body cancer.

Surg Case Rep 2019 Feb 13;5(1):21. Epub 2019 Feb 13.

Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.

Background: Pancreatic ductal adenocarcinoma (PDAC) readily metastasizes to the lymph nodes, liver, lung, and peritoneum; however, gastric and gallbladder metastases are rare. We report a case of metachronous gastric and gallbladder metastases from PDAC.

Case Presentation: The patient is a 71-year-old man who underwent distal pancreatectomy for PDAC. Read More

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http://dx.doi.org/10.1186/s40792-019-0581-1DOI Listing
February 2019

Breast Cancer with Paraneoplastic Syndrome in a 72 Year Old Male Patient.

Mymensingh Med J 2019 Jan;28(1):254-258

Dr Sabrina Yesmin, Associate Professor and Head, Department of Medicine, Dr Sirajul Islam Medical College Hospital, Dhaka, Bangladesh; E-mail:

Breast cancer in male is rare which accounts about 1% of all malignant breast neoplasm cases. Since paraneoplastic syndrome is unusual with male breast cancer, very few reported cases are found. A72- year-old gentleman presented with proximal myopathy in all four limbs was referred to Dr. Read More

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January 2019

Low-dose apatinib optimizes tumor microenvironment and potentiates antitumor effect of PD-1/PD-L1 blockade in lung cancer.

Cancer Immunol Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Medical Oncology, University of Colorado Anschutz Medical Campus.

Lack of response to treatment in most lung cancer patients suggests the value of broadening the benefit of anti-PD-1/PD-L1 monotherapy. Judicious dosing of anti-angiogenic agents such as apatinib (VEGFR2-TKI) can modulate the tumor immunosuppressive microenvironment, which contributes to resistance to anti-PD-1/PD-L1 treatment. We therefore hypothesized that inhibiting angiogenesis could enhance therapeutic efficacy of PD-1/PD-L1 blockade. Read More

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0640DOI Listing
February 2019

CXCL17-derived CD11bGr-1 myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB.

Breast Cancer Res 2019 Feb 12;21(1):23. Epub 2019 Feb 12.

Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.

Background: Metastasis is the major cause of death from breast cancer. Colonization and adaption of metastatic cells in distant organs is a rate-limiting step of the cancer spreading. The underlying mechanisms responsible for the colonization of breast cancer to lung metastatic niches are not fully understood. Read More

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https://breast-cancer-research.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s13058-019-1114-3DOI Listing
February 2019
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DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.

J Exp Clin Cancer Res 2019 Feb 12;38(1):72. Epub 2019 Feb 12.

Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.

Background: Damage-regulated autophagy modulator 2(DRAM2) is associated with autophagy processes. However, the role of DRAM2 in the progression of human neoplasms is still unknown. Here, we show that DRAM2 may act as an oncogenic regulator in non-small cell lung cancer (NSCLC). Read More

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-
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http://dx.doi.org/10.1186/s13046-019-1068-4DOI Listing
February 2019
1 Read

Different next-generation sequencing pipelines based detection of tumor DNA in cerebrospinal fluid of lung adenocarcinoma cancer patients with leptomeningeal metastases.

BMC Cancer 2019 Feb 12;19(1):143. Epub 2019 Feb 12.

Department of Oncology, Huashan Hospital Fudan University, Shanghai, China.

Background: The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different next-generation sequencing (NGS) pipelines in paired cerebrospinal fluid (CSF) and plasma samples from lung adenocarcinoma (LAC) patients with leptomeningeal metastases (LM).

Methods: Paired CSF cell free DNA (cfDNA), CSF cells, plasma and formalin-fixed and paraffin-embedded (FFPE) samples of primary tumors were collected from 29 LAC patients with LM to detect the mutations by different NGS pipelines. Read More

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http://dx.doi.org/10.1186/s12885-019-5348-3DOI Listing
February 2019

Spontaneous pneumothorax in the elderly: a sign of a malignancy?

Asian Cardiovasc Thorac Ann 2019 Feb 12:218492319831840. Epub 2019 Feb 12.

2 Thoracic Surgery Clinic, University of Health Sciences, Sureyyapasa Training and Research Hospital, Istanbul, Turkey.

Background: Spontaneous pneumothorax usually occurs as a result of rupture of a subpleural bleb or emphysematous bulla. Spontaneous pneumothorax, which is more common in younger age groups, might be the first sign of pulmonary malignancy, especially when it manifests in older patients.

Methods: Data of all patients who were treated for spontaneous pneumothorax in our clinic between June 2013 and June 2017 were examined retrospectively. Read More

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http://dx.doi.org/10.1177/0218492319831840DOI Listing
February 2019

Radiochemotherapy combined with NK cell transfer followed by second-line PD-1 inhibition in a patient with NSCLC stage IIIb inducing long-term tumor control: a case study.

Strahlenther Onkol 2019 Feb 11. Epub 2019 Feb 11.

Radiation Immuno-Oncology, Center for Translational Cancer Research TUM (TranslaTUM), Einsteinstr. 25, 81675, Munich, Germany.

Background: Membrane heat shock protein 70 (mHsp70) is indicative of high-risk tumors and serves as a tumor-specific target for natural killer (NK) cells stimulated with Hsp70 peptide (TKD) and Interleukin(IL)-2. Radiochemotherapy (RCT), mHsp70-targeting NK cells, and programmed death(PD)-1 inhibition were combined to improve the efficacy of tumor-specific immune cells in a non-small cell lung carcinoma (NSCLC) patient.

Patient: Following simultaneous RCT (64. Read More

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http://link.springer.com/10.1007/s00066-019-01434-9
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http://dx.doi.org/10.1007/s00066-019-01434-9DOI Listing
February 2019
2 Reads

Metastatic tumors in the pancreas: the role of endoscopic ultrasound-guided fine-needle aspiration.

Rev Esp Enferm Dig 2019 Feb 11. Epub 2019 Feb 11.

Aparato Digestivo, Clínica Universidad de Navarra.

Background And Objectives: there are few published data on the use of EUS guided fine-needle aspiration in secondary pancreatic lesions. We describe the largest series published so far in a European country.

Patients And Methods: a retrospective review of the cases identified in our institution from 2004 to 2016 has been recorded. Read More

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http://dx.doi.org/10.17235/reed.2019.5914/2018DOI Listing
February 2019
1 Read

Left mediastinal node dissection after arterial ligament transection via video-assisted thoracoscopic surgery for potentially advanced stage I non-small cell lung cancer.

J Thorac Dis 2018 Dec;10(12):6458-6465

Department of General Thoracic Surgery, Jichi Medical University, Shimotsuke-shi, Tochigi, Japan.

Background: Left mediastinal node dissection during lung cancer surgery can be difficult because paratracheal and subcarinal lymph nodes are concealed by mediastinal structures. Arterial ligament transection (ALT) offers a wide surgical view of concealed mediastinal spaces, thus enabling extended lymph node dissection (LND). We analyzed surgical outcomes of patients who underwent extended LND after ALT via video-assisted thoracoscopic surgery (VATS) for potentially node-positive clinical stage I non-small cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.21037/jtd.2018.11.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344703PMC
December 2018

Anaplastic Lymphoma Kinase (ALK)-positive Tumors: Clinical, Radiographic and Molecular Profiles, and Uncommon Sites of Metastases in Patients With Lung Adenocarcinoma.

Am J Clin Oncol 2019 Feb 5. Epub 2019 Feb 5.

Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center, Duarte, CA.

Introduction: Anaplastic lymphoma kinase (ALK) gene rearrangements are observed in about 4% to 8% non-small cell lung cancer (NSCLC). ALK+ tumors have been associated with increased pleural and pericardial disease. Our primary objective was to determine the uncommon sites of metastasis of ALK+ NSCLC. Read More

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http://dx.doi.org/10.1097/COC.0000000000000508DOI Listing
February 2019
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Prognostic significance of doubling time in patients undergoing radical surgery for metachronous peritoneal metastases of colorectal cancer.

Int J Colorectal Dis 2019 Feb 9. Epub 2019 Feb 9.

Department of Surgical Oncology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: The doubling times of tumor volume and tumor markers are associated with the prognosis of liver or lung metastases from colorectal cancer (CRC). However, no studies have assessed peritoneal metastases. Therefore, we aimed to elucidate the association between doubling time and the prognosis of patients who underwent radical surgery for metachronous peritoneal metastases of CRC. Read More

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http://dx.doi.org/10.1007/s00384-019-03259-5DOI Listing
February 2019
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Advanced Hepatocellular Carcinoma with Bone Metastases: Prevalence, Associated Factors, and Survival Estimation.

Med Sci Monit 2019 Feb 10;25:1105-1112. Epub 2019 Feb 10.

Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Moscow, Russian Federation.

BACKGROUND The objective of the present research was to explore the prevalence, risk, and prognostic factors associated with bone metastases (BM) in newly diagnosed hepatocellular carcinoma (HCC) patients. MATERIAL AND METHODS From 36 507 HCC patients who were registered in Surveillance, Epidemiology, and End Results (SEER) database, we enrolled 1263 with BM at the initial diagnosis of HCC from 2010 to 2014. Kaplan-Meier curves and log-rank tests were used to estimate overall survival for different subgroups. Read More

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http://dx.doi.org/10.12659/MSM.913470DOI Listing
February 2019
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Detection of distant metastatic disease by positron emission tomography with F-fluorodeoxyglucose (FDG-PET) at initial staging of cervical carcinoma.

Int J Gynecol Cancer 2019 Feb 9. Epub 2019 Feb 9.

Department of Radiation Oncology, Washington University in Saint Louis, St Louis, Missouri, USA

Objective: The detection of distant metastatic disease in cervical cancer patients at diagnosis is critical in accurate prognostication and directing treatment strategies. This study describes the frequency and sites of distant metastatic disease at diagnosis in patients with cervical cancer as detected by positron emission tomography with F-fluorodeoxyglucose (FDG-PET).

Methods: Patients with newly diagnosed cervical cancer underwent pre-treatment whole-body FDG-PET starting in 1997 at an academic institution. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000108DOI Listing
February 2019
1 Read

Addition of radium-223 to abiraterone acetate and prednisone or prednisolone in patients with castration-resistant prostate cancer and bone metastases (ERA 223): a randomised, double-blind, placebo-controlled, phase 3 trial.

Lancet Oncol 2019 Feb 6. Epub 2019 Feb 6.

University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Abiraterone acetate plus prednisone or prednisolone improves progression-free survival and overall survival in patients with metastatic castration-resistant prostate cancer. Radium-223 improves overall survival and delays the onset of symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases. We assessed concurrent treatment with abiraterone acetate plus prednisone or prednisolone and radium-223 in such patients. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30860-XDOI Listing
February 2019
1 Read

Metastatic Profile of Colorectal Cancer: Interplay Between Primary Tumor Location and KRAS Status.

J Surg Res 2019 Feb 5. Epub 2019 Feb 5.

Division of Surgical Oncology, National Cancer Centre, Singapore. Electronic address:

Background: Mutant KRAS tumors are purported to metastasize differently than wild-type KRAS tumors. The biological heterogeneity of tumors from different parts of the colon are also reported to affect metastasis. This study aims to characterize the metastatic profile by evaluating these factors in unison. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.025DOI Listing
February 2019
1 Read

Mixed response to osimertinib and the beneficial effects of additional local therapy.

Thorac Cancer 2019 Feb 8. Epub 2019 Feb 8.

Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

Background: Although non-small cell lung cancers (NSCLCs) harboring EGFR mutations initially respond well to EGFR-tyrosine kinase inhibitors (TKIs), they typically progress after approximately one year. The EGFR T790M mutation is the most common resistance mechanism. NSCLCs with T790M respond well to osimertinib; however, the heterogeneity of NSCLCs may limit the efficacy. Read More

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http://doi.wiley.com/10.1111/1759-7714.12991
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http://dx.doi.org/10.1111/1759-7714.12991DOI Listing
February 2019
5 Reads

Unusual radiologic manifestation of pseudoprogression in pulmonary metastases after durvalumab treatment in metastatic bladder urothelial cancer.

Thorac Cancer 2019 Feb 7. Epub 2019 Feb 7.

Department of Radiology, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea.

Durvalumab is an immune checkpoint inhibitor that blocks PD-L1. Unlike cytotoxic chemotherapy or molecularly targeted agents, immune checkpoint inhibitors occasionally present distinct response patterns, including radiologic pseudoprogression (initial tumor enlargement with subsequent tumor regression) and immune-related adverse events in normal tissues. We report a case of unusual computed tomography (CT) findings of pseudoprogression of pulmonary metastases in a patient with metastatic bladder cancer after durvalumab treatment: multiple pulmonary metastases turned into ground-glass opacity on first follow-up CT; on second follow-up CT, and after sustained treatment of the PD-L1 inhibitor, the lesion was resolved. Read More

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http://dx.doi.org/10.1111/1759-7714.12994DOI Listing
February 2019

Understanding key symptoms, side effects, and impacts of HR+/HER2- advanced breast cancer: qualitative study findings.

J Patient Rep Outcomes 2019 Feb 7;3(1):10. Epub 2019 Feb 7.

Northwestern University Feinberg School of Medicine, 633 N. Saint Clair St., 19th Floor, Chicago, IL, 60611, USA.

Background: Patients with breast cancer experience a variety of disease symptoms and treatment-related side effects that can adversely affect functioning. The breast cancer experience may differ across disease stages and biomarker subtypes. This study identified relevant disease symptoms, treatment-related side effects, and physical functioning impacts in women with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer. Read More

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http://dx.doi.org/10.1186/s41687-019-0098-1DOI Listing
February 2019

Biomarker concordance between primary colorectal cancer and its metastases.

EBioMedicine 2019 Feb 4. Epub 2019 Feb 4.

Colorectal & Peritoneal Oncology Centre, The Christie NHS Foundation Trust, Manchester, UK; Division of Cancer Sciences, School of Medical Science, Faculty of Biology, Medicine and Health, University of Manchester, UK. Electronic address:

Background: The use of biomarkers to target anti-EGFR treatments for metastatic colorectal cancer (CRC) is well-established, requiring molecular analysis of primary or metastatic biopsies. We aim to review concordance between primary CRC and its metastatic sites.

Methods: A systematic review and meta-analysis of all published studies (1991-2018) reporting on biomarker concordance between primary CRC and its metastatic site(s) was undertaken according to PRISMA guidelines using several medical databases. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.01.050DOI Listing
February 2019
2 Reads

Management of brain metastases from large cell neuroendocrine carcinoma of the lung: improved outcomes with radiosurgery.

Acta Oncol 2019 Feb 7:1-6. Epub 2019 Feb 7.

a Division of Radiation Oncology , Allegheny Health Network Cancer Institute , Pittsburgh , PA , USA.

Objectives: Large cell neuroendocrine carcinoma (LCNEC) of the lung is a rare pulmonary tumor, having similar natural history and management strategy as small cell lung cancer. Therefore, the management of brain metastases in these patients has mirrored that of SCLC through the use of whole brain radiation therapy (WBRT). We used the National Cancer Database (NCDB) to look at predictors of stereotactic radiosurgery (SRS) and any potential differences in outcomes for patients with brain metastases from LCNEC. Read More

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http://dx.doi.org/10.1080/0284186X.2018.1564841DOI Listing
February 2019
1 Read

Visceral Fat Volume From Standard Preoperative CT is an Independent Predictor of Short-term Survival in Patients Undergoing Surgery for Metastatic Spine Disease.

Clin Spine Surg 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Study Design: This is a retrospective cohort.

Objective: Determine the relationship of body morphometry to postoperative survival in patients with vertebral metastases.

Summary Of Background Data: Most operations for vertebral metastases aim for palliation not cure, yet expected patient survival heavily influences treatment plans. Read More

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http://dx.doi.org/10.1097/BSD.0000000000000784DOI Listing
February 2019
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NF-κB-Induced Upregulation of miR-548as-3p Increases Invasion of NSCLC by Targeting PTEN.

Anticancer Agents Med Chem 2019 Feb 6. Epub 2019 Feb 6.

Department of Medical Genetics, Faculty of Medicine, cILTAM Cancer Biology Laboratory, Pamukkale University, Kinikli, Denizli. Turkey.

Background: Non-Small Cell Lung Cancer (NSCLC) is an aggressive cancer type due to high metastatic capacity. Nuclear Factor Kappa B (NF-κB) is a consistently active transcription factor in malignant lung cancer cells and has crucial significance in NSCLC progression. It is also implicated in the transcriptional regulation of many genes including microRNAs (miRNAs) that function as tumor suppressor or oncogene. Read More

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http://dx.doi.org/10.2174/1871520619666190206165215DOI Listing
February 2019
4 Reads

Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change.

An Bras Dermatol 2019 Jan-Feb;94(1):76-78

Department of Pathology, Laboratório Bacchi, Botucatu (SP), Brazil.

Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence. Cutaneous metastases from the breast are the most frequent in women and cutaneous metastases from the lung are the most frequent in men. Thyroid carcinoma, despite representing the most frequent endocrine neoplasm, is considered a rare neoplasm, corresponding to 1% of malignant neoplasms diagnosed. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20198299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360978PMC
March 2018
3 Reads

Clinical outcomes of advanced stage cancer patients treated with sequential immunotherapy in phase 1 clinical trials.

Invest New Drugs 2019 Feb 6. Epub 2019 Feb 6.

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.

Background Given the increasing number of available immunotherapeutic agents, more patients are presenting after failing immunotherapy in need of new treatment options. In this study, we investigated the clinical outcomes of patients treated with sequential immunotherapy. Methods We performed a retrospective review of 90 advanced stage cancer patients treated on immunotherapy-based phase 1 clinical trials at Winship Cancer Institute from 2009 to 2017. Read More

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http://dx.doi.org/10.1007/s10637-019-00736-0DOI Listing
February 2019

Bone marrow biopsy in the initial staging of Ewing sarcoma: Experience from a single institution.

Pediatr Blood Cancer 2019 Feb 5:e27653. Epub 2019 Feb 5.

Chemotherapy Section, IRCCS-Rizzoli Orthopaedic Institute, Bologna, Italy.

Background: Ewing sarcoma (ES) is the second most common bone tumor in adolescents and children. Staging workup for ES includes imaging and bone marrow biopsy (BMB). The effective role of BMB is now under discussion. Read More

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http://dx.doi.org/10.1002/pbc.27653DOI Listing
February 2019
2.562 Impact Factor

Clear Cell Myoepithelial Carcinoma Arising from the Hard Palate with Metastasis to the Lungs.

Case Rep Pathol 2019 6;2019:3863270. Epub 2019 Jan 6.

Department of Pathology at Medical College of Georgia at Augusta University, Augusta, GA, USA.

Myoepithelial carcinoma is an uncommon tumor of the salivary glands, most commonly the parotid gland. Clear cell myoepithelial carcinoma is a rare variant with an aggressive behavior. Here, we describe a case of clear cell myoepithelial carcinoma arising from the hard palate in an elderly male who underwent resection of the tumor and postop radiation. Read More

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http://dx.doi.org/10.1155/2019/3863270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339750PMC
January 2019
1 Read

Local control rates in stereotactic body radiotherapy (SBRT) of lung metastases associated with the biologically effective dose.

Rep Pract Oncol Radiother 2019 Mar-Apr;24(2):142-150. Epub 2019 Jan 22.

Servicio de Radiofísica y Protección Radiológica, Hospital Universitario HM Sanchinarro, Oña, 10, 28050 Madrid, Spain.

Aim: To evaluate dose differences in lung metastases treated with stereotactic body radiotherapy (SBRT), and the correlation with local control, regarding the dose algorithm, target volume and tissue density.

Background: Several studies showed excellent local control rates in SBRT for lung metastases, with different fractionation schemes depending on the tumour location or size. These results depend on the dose distributions received by the lesions in terms of the tissue heterogeneity corrections performed by the dose algorithms. Read More

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http://dx.doi.org/10.1016/j.rpor.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352745PMC
January 2019

DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancer.

Mod Pathol 2019 Feb 5. Epub 2019 Feb 5.

Department of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Pulmonary enteric adenocarcinoma is a rare non-small cell lung cancer subtype. It is poorly characterized and cannot be distinguished from metastatic colorectal or upper gastrointestinal adenocarcinomas by means of routine pathological methods. As DNA methylation patterns are known to be highly tissue specific, we aimed to develop a methylation-based algorithm to differentiate these entities. Read More

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http://www.nature.com/articles/s41379-019-0207-y
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http://dx.doi.org/10.1038/s41379-019-0207-yDOI Listing
February 2019
3 Reads

Incidence, patterns and prognosis of first distant recurrence after surgically treated early stage endometrial cancer: Results from the multicentre FRANCOGYN study group.

Eur J Surg Oncol 2019 Jan 19. Epub 2019 Jan 19.

Department of Gynecology and Obstetrics, Tenon University Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Sorbonne University, Paris, France; INSERM UMR S 938, Université Pierre et Marie Curie, Paris, France.

Patterns of distant metastatic failure of endometrial cancer (EC) by specific anatomic site are not well described in the literature. In this manuscript, we evaluated the metastatic patterns of EC cancer and analysed the potential distribution of metastatic disease in this malignancy.

Methods: A total of 1444 women with EC were identified. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.011DOI Listing
January 2019
2 Reads

Mutational status of lung cancer patients and survival outcomes for patients with limited brain metastases.

J BUON 2018 Dec;23(7):156

Ankara Yildirim Beyazit University, Faculty of Medicine, Department of Medical Oncology, Ankara, Turkey.

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December 2018

Proposal for a combined histo-molecular algorithm to distinguish multiple primary adenocarcinomas from intrapulmonary metastasis in patients with multiple lung tumors.

J Thorac Oncol 2019 Feb 2. Epub 2019 Feb 2.

Department of Biochemistry, Unit of Pharmacogenetic and Molecular Oncology, Georges Pompidou European Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; INSERM UMR-S1147, Paris Sorbonne Cite University, Paris, France.

Introduction: Multiple nodules in lung are diagnosed with an increasing frequency due to high quality CT-scan imaging. In patients suffering from lung cancer, this situation represents up to 10% of operated patients. For clinical management, it is important to classify the disease as intra-pulmonary metastasis or multiple primary lung carcinomas to define TNM classification and optimize therapeutic options. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.01.017DOI Listing
February 2019
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CT-guided Microcoil Pulmonary Nodule Localization prior to Video-assisted Thoracoscopic Surgery: Diagnostic Utility and Recurrence-Free Survival.

Radiology 2019 Feb 5:181674. Epub 2019 Feb 5.

From the Divisions of Cardiothoracic Imaging (J.C.L.R., K.H., J.K., T.B.C., M.P., E.T.N.), Thoracic Surgery (A.F.P., T.K.W., S.K., M.C., K.Y.), and Thoracic Pathology (M.C.), Toronto General Hospital, University Health Network, 585 University Ave, Toronto, ON, Canada M5G 2N2; Postgraduate Medical Education, Department of Medical Imaging, University of Toronto, Toronto, Canada (J.C.L.R.); and Department of Radiology, Royal United Hospitals Bath NHS Foundation Trust, Combe Park, Bath, England, United Kingdom, BA1 3NG (J.C.L.R.).

Background CT-guided microcoil localization has been shown to reduce the need for thoracotomy or video-assisted thoracoscopic surgery (VATS) anatomic resection. However, only short-term follow-up after CT-guided microcoil localization and lung resection has been previously reported. Purpose To assess the diagnostic utility and recurrence-free survival over a minimum of 2 years following CT-guided microcoil localization and VATS. Read More

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http://dx.doi.org/10.1148/radiol.2019181674DOI Listing
February 2019

Prevalence and prognostic impact of synchronous distant metastases in patients with hypopharynx squamous cell carcinomas: a SEER-based study.

J Cancer 2019 1;10(3):620-626. Epub 2019 Jan 1.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

The prognosis of hypopharynx squamous cell carcinoma (SCC) patients with distant metastasis is poor. We sought to explore prevalence and prognostic impact of synchronous distant metastases among patients with hypopharynx SCC in this study. Patients with histologically proven hypopharynx SCC were extracted from the Surveillance, Epidemiology and End Results (SEER) database between 2010 and 2014. Read More

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http://dx.doi.org/10.7150/jca.28554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360430PMC
January 2019

Prognostic Significance of Young Age and Non-Bone Metastasis at Diagnosis in Patients with Metastatic Prostate Cancer: a SEER Population-Based Data Analysis.

J Cancer 2019 1;10(3):556-567. Epub 2019 Jan 1.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, P.R. China.

This study compared the clinicopathological features and survival of metastatic prostate cancer (mPCa) after stratification by age and non-bone-related metastasis to identify prognostic factors. Patients with mPCa between 2010 and 2015 were identified from the Surveillance, Epidemiology and End Results database and analyzed. The overall survival (OS) rate was assessed using the Kaplan-Meier curve and log-rank test as well as multivariate Cox regression analysis. Read More

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http://dx.doi.org/10.7150/jca.29481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360431PMC
January 2019
1 Read
2.639 Impact Factor

Establishment and characterization of a patient-derived circulating lung tumor cell line in vitro and in vivo.

Cancer Cell Int 2019 29;19:21. Epub 2019 Jan 29.

Institute of Traditional Chinese Medicine Oncology, Shanghai Institute of Traditional Chinese Medicine, Shanghai, 200032 People's Republic of China.

Background: Circulating tumor cells (CTCs) have been described as a population of cells that may seed metastasis, which is a reliable target for the prevention of metastases in lung cancer patients at the early stage. The culturing of CTCs in vitro can be used to study the mechanism of lung cancer metastasis and to screen antimetastasis drugs. This study aims to establish CTC cell line in vitro and explore the potential mechanism of its metastasis. Read More

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http://dx.doi.org/10.1186/s12935-019-0735-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352330PMC
January 2019
1 Read