856,563 results match your criteria Lung India : official organ of Indian Chest Society[Journal]


Candida albicans-induced acute lung injury through activating several inflammatory signaling pathways in mice.

Int Immunopharmacol 2019 Apr 17;72:275-283. Epub 2019 Apr 17.

Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; Anhui Center for Surveillance of Bacterial Resistance, Hefei 230032, China. Electronic address:

Candida albicans infection-induced acute lung injury is one of the most prevalent diseases in immunosuppressive individual. Nevertheless, the mechanism by which Candida albicans induced acute lung injury remains unclear. The present study investigated the mechanism by which Candida albicans induced acute lung injury in mice. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.026DOI Listing

YY1 regulates cancer cell immune resistance by modulating PD-L1 expression.

Drug Resist Updat 2019 Apr 9;43:10-28. Epub 2019 Apr 9.

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, United States. Electronic address:

Recent advances in the treatment of various cancers have resulted in the adaptation of several novel immunotherapeutic strategies. Notably, the recent intervention through immune checkpoint inhibitors has resulted in significant clinical responses and prolongation of survival in patients with several therapy-resistant cancers (melanoma, lung, bladder, etc.). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13687646193001
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http://dx.doi.org/10.1016/j.drup.2019.04.001DOI Listing
April 2019
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Genetic effects of welding fumes on the development of respiratory system diseases.

Comput Biol Med 2019 Apr 8;108:142-149. Epub 2019 Apr 8.

Bone Biology Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; Discipline of Pathology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia. Electronic address:

Background: The welding process releases potentially hazardous gases and fumes, mainly composed of metallic oxides, fluorides and silicates. Long term welding fume (WF) inhalation is a recognized health issue that carries a risk of developing chronic health problems, particularly respiratory system diseases (RSDs). Aside from general airway irritation, WF exposure may drive direct cellular responses in the respiratory system which increase risk of RSD, but these are not well understood. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.04.004DOI Listing

Modificated Mahuang-Tang, a traditional herbal medicine suppresses inflammatory responses induced by cigarette smoke in human airway epithelial cell and mice.

Phytomedicine 2018 Dec 1;59:152777. Epub 2018 Dec 1.

College of Veterinary Medicine (BK21 Plus Project Team), Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 500-757, Republic of Korea. Electronic address:

Background: Cigarette smoke (CS) is a major contributor to the high incidence of chronic obstructive pulmonary disease (COPD) featured as chronic inflammation and airway obstruction. Mahuang-Tang is a traditional polyherbal mixture composed of four different herbs. It is widely used in Asia as a remedy for allergic reaction and inflammation. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.037DOI Listing
December 2018

Phosphodiesterase-4 Inhibitor Roflumilast Attenuates Pulmonary Air Emboli-Induced Lung Injury.

J Surg Res 2019 Apr 17;241:24-30. Epub 2019 Apr 17.

Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, School of Medicine, Tzu-Chi University, Hualien, Taiwan. Electronic address:

Background: Pulmonary air embolism (PAE)-induced acute lung injury (ALI) can be caused by massive air entry into the lung circulation. PAE can occur during diving, aviation, and some iatrogenic invasive procedures. PAE-induced ALI presents with severe inflammation, hypoxia, and pulmonary hypertension, and it is a serious complication resulting in significant morbidity and mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193014
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http://dx.doi.org/10.1016/j.jss.2019.03.028DOI Listing
April 2019
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Long term effects of chronic prenatal exposure to hypercarbia on organ growth and cardiovascular responses to adrenaline and hypoxia in common snapping turtles.

Comp Biochem Physiol A Mol Integr Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Biological Sciences, Developmental Integrative Biology Cluster, University of North Texas, Denton, TX 76203-5220, USA. Electronic address:

Reptilian embryos often face challenging environmental gas compositions during incubation, which may inflict long lasting effects in the individuals' physiological responses. These conditions can have a lasting effect on the animal into juvenile life as chronic prenatal exposure to hypercarbia results in enlarged hatchling organ size, higher growth rate and resting metabolic rate, although relatively smaller increment in metabolic scope during digestion. Therefore, we wanted to verify whether prenatal hypercarbia exposure would cause persistent effects on morphology and physiological responses in C. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10956433193000
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http://dx.doi.org/10.1016/j.cbpa.2019.04.009DOI Listing
April 2019
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Conduction Patterns of Idiopathic Arrhythmias from the Endocardium and Epicardium of Outflow Tracts: New Insights with Non-Invasive Electroanatomic Mapping.

Heart Rhythm 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiac Electrophysiology, Northwell Health - Lenox Hill Heart and Lung 100 East 77th Street New York, NY-10021.

Background: Idiopathic arrhythmias commonly arise from the septal right ventricular outflow tract (sRVOT), sinuses of Valsalva (SoV) and great cardiac vein (GCV). Predicting exact site of origin is important for preparation for catheter ablation.

Objectives: To examine diagnostic value of non-invasive electroanatomic mapping (NIEAM) to differentiate between sRVOT, SoV and GCV origin and compare it to that of 12-lead ECG. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.04.026DOI Listing

Dual role of autophagy/mitophagy in chronic obstructive pulmonary disease.

Pulm Pharmacol Ther 2019 Apr 17. Epub 2019 Apr 17.

Department of Integrated Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Chronic obstructive pulmonary disease (COPD) is a common lung disease characterised by progressive, irreversible airflow limitation. Multiple regulatory pathways are involved in COPD pathogenesis. Emerging evidence from clinical and basic medical research has suggested that autophagy-a highly conserved catabolic process mediated under various cellular stress conditions-plays a role in the development and prognosis of COPD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10945539183024
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http://dx.doi.org/10.1016/j.pupt.2019.04.002DOI Listing
April 2019
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Targeted methods for molecular characterization of EGFR mutational profile in lung cancer Moroccan cohort.

Gene 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy of Casablanca, University Hassan II, Casablanca 20250, Morocco.

The study of EGFR gene mutational profile in NSCLC patients has a special clinical significance in the selection of patients for tyrosine-kinase inhibitors therapy. From 2017, the targeted therapy started to be accessible in public sector in Morocco, thus, the implementation of techniques for the molecular characterization of EGFR mutations in the laboratories became a necessity. The aim of this study was to present targeted methods "ADx-ARMS technology and the Idylla™ system" for the identification of EGFR mutational profile, methods that can be implemented in our clinical laboratories for routine analysis instead of outsourcing analysis to other countries. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193039
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http://dx.doi.org/10.1016/j.gene.2019.04.044DOI Listing
April 2019
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Increased expression of miR-155 correlates with abnormal allograft status in solid organ transplant patients and rat kidney transplantation model.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address:

Aims: Increasing evidence has shown the diagnostic value of miR-155 in organ transplantation. The dysregulation of miR-155 is reported to be associated with development of acute or chronic complications in solid organ transplant recipients. Here, we summarized related evidence to explore the correlation between the dysregulation of miR-155 and various allograft dysfunction in transplant recipients, and verified the dynamic change of miR-155 level in acute rejection (AR) using a rat renal transplantation model. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.043DOI Listing

Hyaluronic acid - dihydroartemisinin conjugate: Synthesis, characterization and in vitro evaluation in lung cancer cells.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Product Development Cell-II, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India. Electronic address:

In recent years, a great deal of attention has been given towards re-purposing and re-innovating the potential drugs. In this regard, dihydroartemisinin (DHA) has been reported to demonstrate anti-proliferative effects on various cancerous cells viz. breast, liver and lung. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.124DOI Listing

Adjuvant Therapy for Patients with Early Large Cell Lung Neuroendocrine Cancer: A National Analysis.

Ann Thorac Surg 2019 Apr 17. Epub 2019 Apr 17.

Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center.

Background: Current guidelines do not routinely recommend adjuvant therapy for resected stage I large cell lung neuroendocrine cancer (LCNEC). However, data regarding the role of adjuvant therapy in early LCNEC are limited. This National Cancer Database (NCDB) analysis was performed to improve the evidence guiding adjuvant therapy for early LCNEC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193056
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http://dx.doi.org/10.1016/j.athoracsur.2019.03.053DOI Listing
April 2019
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Robotic Assisted Lobectomy For Non-Small Cell Lung Cancer: A Comprehensive Institutional Experience.

Ann Thorac Surg 2019 Apr 17. Epub 2019 Apr 17.

Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Background: It is unclear whether the enhanced dexterity and visualization of the surgical robot lessens morbidity and influences staging or survival. We compared outcomes of robotic-assisted lobectomy (RAL) with thoracoscopic (VAL) or open lobectomy (OL) of non-small cell lung cancer (NSCLC).

Methods: Using a prospective surgical database, perioperative and cancer related outcomes of patients who received a lobectomy for NSCLC from 2011-2017 were analyzed. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.051DOI Listing

Off-pump bilateral lung transplantation via median sternotomy: a novel approach with potential benefits.

Ann Thorac Surg 2019 Apr 17. Epub 2019 Apr 17.

Cardiothoracic Services, Freeman Hospital, Newcastle upon Tyne, United Kingdom. Electronic address:

The clamshell incision is worldwide the standard approach for bilateral lung transplantation. There is very limited experience with bilateral lung transplantation via median sternotomy so far and the use of cardiopulmonary bypass seems to be mandatory in all these cases accepting the potential disadvantages of the extracorporeal circulation. We describe a novel approach for bilateral lung transplantation as off-pump technique via median sternotomy which has the potential to combine the advantages of median sternotomy with less postoperative pain and better chest wall function and off-pump technique with reduced risk of primary graft dysfunction and bleeding complications. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.055DOI Listing

Repressive role of stabilized HIF1α expression on TGFβ-induced extracellular matrix production in lung cancer cells.

Cancer Sci 2019 Apr 20. Epub 2019 Apr 20.

Department of Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Activation of transforming growth factor β (TGFβ) combined with persistent hypoxia are often affecting the tumor microenvironment. Disruption of cadherin/catenin complexes induced by these stimulations yields aberrant extracellular matrix (ECM) production, characteristics of an epithelial-mesenchymal transition (EMT). Hypoxia-inducible factors (HIFs), the hallmark of the response to hypoxia, play differential roles during development of diseases. Read More

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http://dx.doi.org/10.1111/cas.14027DOI Listing

A Psoriasiform Drug Eruption Secondary to Nivolumab for Hepatocellular Carcinoma: a Case Report.

Hepatology 2019 Apr 20. Epub 2019 Apr 20.

Corporal Michael J Crescenz VA Medical Center, Pathology, 3900 Woodland Avenue, Philadelphia, Pennsylvania, United States.

Nivolumab, an immune checkpoint inhibitor that acts by preventing programmed-death ligand 1 (PD-L1) from binding to the programmed cell death protein-1 (PD-1) receptor, is utilized to treat a variety of cancers including renal cell carcinoma, non-small cell lung cancer, and metastatic melanoma. Currently, nivolumab is FDA-approved as a second-line treatment for advanced hepatocellular carcinoma (HCC) after showing efficacy in patients who progressed on or were intolerant to sorafenib. This article is protected by copyright. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30659
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http://dx.doi.org/10.1002/hep.30659DOI Listing
April 2019
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The allergen-specificity of allergen immunotherapy - doubt no more.

Authors:
Stephen R Durham

Allergy 2019 Apr 20. Epub 2019 Apr 20.

National Heart and Lung Institute, Imperial College London, Dovehouse Street, London.

The ARIA-GA2LEN collaboration published a guide for the design and evaluation of randomised controlled trials of allergen immunotherapy for allergic rhinitis. Several problems in were identified. For example, the severity/persistence of seasonal symptoms in subjects during allergen immunotherapy was noted to be much lower than in trials of pharmacotherapy. Read More

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http://dx.doi.org/10.1111/all.13826DOI Listing

Pressure support ventilation, sigh adjunct to pressure support ventilation, and neurally adjusted ventilatory assist in infants after cardiac surgery: A physiologic crossover randomized study.

Pediatr Pulmonol 2019 Apr 19. Epub 2019 Apr 19.

Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy.

Objectives: We sought to compare gas exchange, respiratory mechanics, and asynchronies during pressure support ventilation (PSV), sigh adjunct to PSV (PSV SIGH), and neurally adjusted ventilatory assist (NAVA) in hypoxemic infants after cardiac surgery.

Design: Prospective, single-center, crossover, randomized physiologic study.

Setting: Tertiary-care pediatric intensive care unit. Read More

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http://dx.doi.org/10.1002/ppul.24335DOI Listing

Wheezing independently predicts viral infection in children with community-acquired pneumonia.

Pediatr Pulmonol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, Federal University of Bahia School of Medicine, Salvador, Brazil.

Aim: To assess whether there was a difference in the frequency of symptoms and signs among children with community-acquired pneumonia (CAP) with viral or bacterial infection.

Methods: A prospective cross-sectional study was conducted in Salvador, Brazil. Children less than 5-years-old hospitalized with CAP were recruited. Read More

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http://dx.doi.org/10.1002/ppul.24339DOI Listing

Lung clearance index for early detection of pulmonary complications after allo-HSCT in children.

Pediatr Pulmonol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Pulmonary chronic graft-vs-host disease (cGvHD) after hematopoietic stem cell transplantation (HSCT) is characterized by impairment of the small airways. Assessment of lung clearance index (LCI) gained from multiple breath washout (MBW) is more sensitive than spirometry in detection of small airways disease. The aim of this study was to describe the development of LCI during the first year after pediatric HSCT and how LCI relates to other pulmonary function parameters and cGvHD. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24340
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http://dx.doi.org/10.1002/ppul.24340DOI Listing
April 2019
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Not just the common cold: Rhinovirus infection in lung allograft recipients.

Respirology 2019 Apr 19. Epub 2019 Apr 19.

National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/resp.13571DOI Listing

Practical approach to establishing pulmonary rehabilitation for people with non-COPD diagnoses.

Respirology 2019 Apr 19. Epub 2019 Apr 19.

Discipline of Physiotherapy, La Trobe University, Melbourne, VIC, Australia.

Pulmonary rehabilitation is a core aspect in the management of patients with chronic respiratory diseases. This paper describes a practical approach to establishing pulmonary rehabilitation for patients with non-COPD diagnoses using examples from the interstitial lung disease (ILD), pulmonary hypertension (PH), bronchiectasis and lung cancer patient populations. Aspects of pulmonary rehabilitation, including the rationale, patient selection, setting of programmes, patient assessment and training components (both exercise and non-exercise aspects), are discussed for these patient groups. Read More

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http://dx.doi.org/10.1111/resp.13562DOI Listing

Optimal Scheduling of Bevacizumab and Pemetrexed/cisplatin Dosing in Non-Small Cell Lung Cancer.

CPT Pharmacometrics Syst Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Iowa State University College of Veterinary Medicine, Ames, IA, U.S.A.

Bevacizumab-pemetrexed/cisplatin (BEV-PEM/CIS) is a first line therapeutic for advanced non-squamous non-small cell lung cancer (NSCLC). Bevacizumab potentiates PEM/CIS cytotoxicity by inducing transient tumor vasculature normalization. BEV-PEM/CIS has a narrow therapeutic window. Read More

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http://dx.doi.org/10.1002/psp4.12415DOI Listing
April 2019
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Bronchiolitis obliterans syndrome as manifestation of lung GVHD: Not the only one - Reply.

Respirology 2019 Apr 19. Epub 2019 Apr 19.

Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/resp.13566DOI Listing

Bronchiolitis obliterans syndrome as manifestation of lung GVHD: Not the only one.

Respirology 2019 Apr 19. Epub 2019 Apr 19.

Division of Respirology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/resp.13567DOI Listing

The cost of diabetic foot ulcers and amputations to the National Health Service in England.

Diabet Med 2019 Apr 19. Epub 2019 Apr 19.

Nottingham University Hospitals NHS Trust, Nottingham, UK.

Aim: To estimate the healthcare costs of diabetic foot disease in England.

Methods: Patient-level data sets at a national and local level, and evidence from clinical studies, were used to estimate the annual cost of health care for foot ulceration and amputation in people with diabetes in England in 2014-2015.

Results: The cost of health care for ulceration and amputation in diabetes in 2014-2015 is estimated at between £837 million and £962 million; 0. Read More

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http://dx.doi.org/10.1111/dme.13973DOI Listing

9za plays cytotoxic and proapoptotic roles and induces cytoprotective autophagy through the PDK1/Akt/mTOR axis in non-small-cell lung cancer.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Non-small-cell lung cancer (NSCLC) is an aggressive subtype of pulmonary carcinomas with high mortality. However, chemotherapy drug resistance and high recurrence rates hinder the curative effect of platinum-based first-line chemotherapy, which makes it urgent to develop new antitumor drugs for NSCLC. 9za, a new candidate drug synthesized by our research group, has been verified with potent antilung cancer activity in preliminary experiments. Read More

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http://dx.doi.org/10.1002/jcp.28679DOI Listing
April 2019
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Trends in radiation dose and image quality for pediatric patients with a multidetector CT and a third-generation dual-source dual-energy CT.

Radiol Med 2019 Apr 19. Epub 2019 Apr 19.

University Politecnica delle Marche, Via Tronto 10/A, 60126, Ancona, Italy.

Aim: To provide an overview on dose reduction and image quality after the installation of a third-generation dual-source CT (dsCT) in a Pediatric Radiology Department.

Materials And Methods: We included pediatric patients (< 20 years old) undergoing CT for oncological staging (neck, chest and abdomen) or low-dose chest CT for lung diseases. Each of these two groups were further divided in two age groups (≤ or > 10 years old) including patients scanned in the same period of two consecutive years, in 2017 with a 16-row LightSpeed CT (GE Healthcare) or in 2018 with a Somatom Force dsCT (Siemens Healthineers). Read More

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http://dx.doi.org/10.1007/s11547-019-01037-5DOI Listing

Unexpected conversion to thoracotomy during thoracoscopic lobectomy: a single-center analysis.

Gen Thorac Cardiovasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Thoracic Surgery, Istinye University Medical Faculty, Liv Hospital Ulus, Istanbul, Turkey.

Background: The aim of this study was to discuss indications and outcomes for conversion to thoracotomy during thoracoscopic lobectomy.

Materials And Methods: Patients who underwent lobectomy for non-small cell lung cancer between January 2012 and December 2016 were evaluated retrospectively. The study included 129 patients who underwent video-assisted thoracoscopic lobectomy (group-V) and 18 patients converted from thoracoscopic lobectomy to thoracotomy due to unexpected intraoperative complications (group-T). Read More

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http://link.springer.com/10.1007/s11748-019-01127-1
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http://dx.doi.org/10.1007/s11748-019-01127-1DOI Listing
April 2019
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Comparison of clinical presentation and incidence of cardiopulmonary complications between male and female Thai patients with early systemic sclerosis: inception cohort study.

Clin Rheumatol 2019 Apr 19. Epub 2019 Apr 19.

Division of Diagnostic Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objectives: To determine the prevalence of clinical manifestations and incidence rate of cardiopulmonary complications in a comparison between men and women with early SSc.

Methods: An inception cohort of early-SSc patients at the Rheumatology Clinic, Maharaj Nakorn Chiang Mai Hospital, between January 2010 and June 2016, was used. All patients were assessed for clinical manifestations and underwent ECG, echocardiography, and HRCT at the study entry and then annually. Read More

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http://dx.doi.org/10.1007/s10067-019-04551-zDOI Listing

Molecular Imaging of a Zirconium-89 Labeled Antibody Targeting Plasmodium falciparum-Infected Human Erythrocytes.

Mol Imaging Biol 2019 Apr 19. Epub 2019 Apr 19.

Preclinical Imaging Facility, The South African Nuclear Energy Corporation SOC Ltd (Necsa), Pelindaba, South Africa.

Purpose: Nuclear imaging is an important preclinical research tool to study infectious diseases in vivo and could be extended to investigate complex aspects of malaria infections. As such, we report for the first time successful radiolabeling of a novel antibody specific to Plasmodium-infected erythrocytes (IIIB6), its in vitro assessment and molecular imaging in nude mice.

Procedures: In vitro confocal microscopy was used to determine the stage-specificity of Plasmodium-infected erythrocytes recognised by IIIB6. Read More

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http://link.springer.com/10.1007/s11307-019-01360-3
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http://dx.doi.org/10.1007/s11307-019-01360-3DOI Listing
April 2019
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Adherence to Long-Term Follow-Up of Patients with Life-Threatening, Inhaled Synthetic Cannabinoids-Associated Coagulopathy in Chicago.

Lung 2019 Apr 19. Epub 2019 Apr 19.

Division of Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Medicine (M/C 719), University of Illinois at Chicago, 840 South Wood Street, Chicago, IL, 60612, USA.

A large-scale outbreak of life-threatening, inhaled synthetic cannabinoids (Spice/K2)-associated coagulopathy with bleeding complications was recently reported in Illinois. The causative agents were brodifacoum, difenacoum, and bromadiolone, potent, long-acting, 4-hydroxycoumarin anticoagulant rodenticides (LAAR) that were mixed with Spice/K2 products procured and then inhaled by the victims. We report on 3 poisoned patients who reside in underserved, socioeconomically disadvantaged neighborhoods of Chicago that were admitted and treated successfully at two inner-city, tertiary care hospitals in Chicago. Read More

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http://dx.doi.org/10.1007/s00408-019-00227-2DOI Listing

Clinico-radiologic features of pleuroparenchymal fibroelastosis in children.

Pediatr Radiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatric Radiology, Texas Children's Hospital, 6701 Fannin St., Houston, TX, 77030, USA.

Background: Pleuroparenchymal fibroelastosis (PPFE) may be underdiagnosed clinically and radiographically in children with a remote history of cancer, leading to a delay in care and unnecessary lung biopsies.

Objective: To describe the characteristic clinical and radiologic findings of PPFE in a cohort of children to facilitate recognition and noninvasive diagnosis.

Materials And Methods: Clinical presentation, history of chemotherapy or radiation therapy, lung or bone marrow transplantation, and lung function testing and outcome were retrospectively extracted from the electronic medical records of eight children treated at our institution's pulmonary medicine clinic with histopathology confirmation of PPFE from 2008 to 2018. Read More

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http://dx.doi.org/10.1007/s00247-019-04405-5DOI Listing

Lung cancer survival and comorbidities in lung cancer screening participants of the Gdańsk screening cohort.

Eur J Public Health 2019 Apr 19. Epub 2019 Apr 19.

Department of Thoracic Surgery, Medical University of Gdańsk, Gdańsk, Poland.

Background: In 2010, the World Health Organisation recommended implementation of screening programmes in four groups of diseases-neoplasms, cardiovascular diseases (CVD), diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD). It is due to the fact that they share the same, modifiable risk factors.

Methods: Between 2009 and 2011, 8637 heavy smokers (aged 50-75, smoking history >20 pack-years) were screened in the Pomeranian Pilot Lung Cancer Screening Programme (PPP) in Gdańsk, Poland. Read More

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http://dx.doi.org/10.1093/eurpub/ckz052DOI Listing

Systematic assessment of the clinicopathological prognostic significance of tissue cytokine expression for lung adenocarcinoma based on integrative analysis of TCGA data.

Sci Rep 2019 Apr 19;9(1):6301. Epub 2019 Apr 19.

Department of Medical Oncology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China.

Dysregulated intratumoral immune reactions are shaped by complex networks of cytokines, which coordinate with tumor cells to determine tumor progression and aggressiveness. In lung adenocarcinoma (LUAD), the role of intratumoral cytokine gene expression for stratifying prognosis has not been systematically investigated. Using high-dimensional datasets of cancer specimens from clinical patients in The Cancer Genome Atlas (TCGA), we explored the transcript abundance and prognostic impact of 27 clinically evaluable cytokines in 500 LUAD tumor samples according to clinicopathological features and two common driver mutations (EGFR and KRAS). Read More

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http://dx.doi.org/10.1038/s41598-019-42345-0DOI Listing

SMURF1-mediated ubiquitination of ARHGAP26 promotes ovarian cancer cell invasion and migration.

Exp Mol Med 2019 Apr 19;51(4):46. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Bao'an Maternity and Child Health Hospital, Jinan University, Shenzhen, 518100, China.

Rho GTPase-activating protein 26 (ARHGAP26) is a negative regulator of the Rho family that converts the small GTP-binding protein RhoA (GTP-RhoA) to its inactive GDP-bound form and is a putative tumor suppressor gene associated with cell growth and migration. Here, the involvement of ARHGAP26 in ovarian cancer cell proliferation and migration was investigated. In this study, low ARHGAP26 expression was observed in ovarian cancer tissues and was associated with a poor overall survival and higher β-catenin expression in patients with ovarian cancer. Read More

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http://www.nature.com/articles/s12276-019-0236-0
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http://dx.doi.org/10.1038/s12276-019-0236-0DOI Listing
April 2019
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Vaccination with a Single-Cycle Respiratory Syncytial Virus Is Immunogenic and Protective in Mice.

J Immunol 2019 Apr 19. Epub 2019 Apr 19.

Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242;

Respiratory syncytial virus (RSV) is the leading cause of severe respiratory tract infection in infants and young children, but no vaccine is currently available. Live-attenuated vaccines represent an attractive immunization approach; however, balancing attenuation while retaining sufficient immunogenicity and efficacy has prevented the successful development of such a vaccine. Recently, a recombinant RSV strain lacking the gene that encodes the matrix (M) protein (RSV M-null) was developed. Read More

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http://dx.doi.org/10.4049/jimmunol.1900050DOI Listing

CRISPR/Cas9 PIG-A Gene Editing in Non-Human Primate Model Demonstrates No Intrinsic Clonal Expansion of PNH HSPCs.

Blood 2019 Apr 19. Epub 2019 Apr 19.

Translational Stem Cell Biology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, United States

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http://dx.doi.org/10.1182/blood.2019000800DOI Listing

Addressing lung transplant with adults with cystic fibrosis: A qualitative analysis of patients' perspectives and experiences.

J Cyst Fibros 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, WA, USA.

Referral for lung transplantation is a complex process that typically begins with a discussion in cystic fibrosis (CF) clinic. We performed a secondary analysis of interviews conducted at the University of Washington CF Clinic as part of a study of unmet palliative care needs, June 2015 - January 2016, among adults with moderate-to-severe CF-related lung disease. Content analysis methods were used to identify themes related to discussion of lung transplant in CF clinic. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.04.007DOI Listing

Characteristics and association with survival of respiratory-related hospitalization in Japanese idiopathic pulmonary fibrosis patients.

Respir Investig 2019 Apr 16. Epub 2019 Apr 16.

Department of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine, Osakasayama, Osaka, Japan. Electronic address:

Background: The characteristics and significance of respiratory-related hospitalization in patients with idiopathic pulmonary fibrosis (IPF) in Asian countries remain unknown. The purpose of this study was to define the characteristics of respiratory-related hospitalization and to inspect the relationship between respiratory-related hospitalization and subsequent survival in patients with IPF in Japanese general practice.

Methods: Patients with IPF who underwent clinical evaluation between February 2008 and August 2017 were screened. Read More

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http://dx.doi.org/10.1016/j.resinv.2019.03.005DOI Listing

Evaluation of changes in the serum levels of Krebs von den Lungen-6 and surfactant protein-D over time as important biomarkers in idiopathic fibrotic nonspecific interstitial pneumonia.

Respir Investig 2019 Apr 16. Epub 2019 Apr 16.

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address:

Background: Some cases of idiopathic fibrotic nonspecific interstitial pneumonia (f-NSIP) show a progressive course that is similar to that of idiopathic pulmonary fibrosis. However, it is difficult to predict poor patient outcomes. This study aimed to evaluate whether serial changes in serum levels of Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) can predict disease progression. Read More

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http://dx.doi.org/10.1016/j.resinv.2019.03.006DOI Listing

Epitope mapping of antibodies induced with a conserved rhinovirus protein generating protective anti-rhinovirus immunity.

Vaccine 2019 Apr 16. Epub 2019 Apr 16.

Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, London, UK; Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK. Electronic address:

Human rhinovirus (RV) infections are the principle cause of common colds and precipitate asthma and chronic obstructive pulmonary disease (COPD) exacerbations. Currently there is no vaccine for RV which is largely due to the existence of ∼160 serotypes/strains. We demonstrated previously that immunising mice with highly conserved VP4 and VP2 regions of the RV polyprotein (RV-A16 VP0) generated cross-reactive immunity to RV in vivo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193045
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http://dx.doi.org/10.1016/j.vaccine.2019.04.018DOI Listing
April 2019
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Effects of epigallocatechin-3-gallate on the HMGB1/RAGE pathway in PM-exposed asthmatic rats.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatrics, Children's Hospital Affiliated of Zhengzhou University, No.33 Long hu Wai huan East Road, Zhengzhou, 450018, Henan, China. Electronic address:

Current studies have shown that long-term exposure to fine particulate matter (PM) can aggravate lung injury in asthmatic children. The HMGB1/RAGE pathway may play an important role, but few studies on the HMGB1/RAGE signaling pathway in PM-induced asthma have been performed. Epigallocatechin-3-gallate (EGCG), which has antioxidant, anti-inflammatory and immunomodulatory effects, has not been examined in studies at home and abroad. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.165DOI Listing

Machine Learning Methods Applied to Predict Ventilator-Associated Pneumonia with Infection via Sensor Array of Electronic Nose in Intensive Care Unit.

Sensors (Basel) 2019 Apr 18;19(8). Epub 2019 Apr 18.

Department of Mechanical Engineering, Yuan Ze University, Chungli 32003, Taiwan.

One concern to the patients is the off-line detection of pneumonia infection status after using the ventilator in the intensive care unit. Hence, machine learning methods for ventilator-associated pneumonia (VAP) rapid diagnose are proposed. A popular device, Cyranose 320 e-nose, is usually used in research on lung disease, which is a highly integrated system and sensor comprising 32 array using polymer and carbon black materials. Read More

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http://dx.doi.org/10.3390/s19081866DOI Listing

Beyond PD-L1 Markers for Lung Cancer Immunotherapy.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, 20-090 Lublin, Poland.

Immunotherapy using immune checkpoints inhibitors has become the standard treatment for first and second line therapy in patients with non-small cell lung cancer (NSCLC). However, proper predictive factors allowing precise qualification of NSCLC patients for immunotherapy have not been developed so far. Expression of PD-L1 on tumor cells and tumor mutation burden are used in qualification of patients to first line therapy with pembrolizumab and atezolizumab in combination with ipilimumab in prospective clinical trials. Read More

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https://www.mdpi.com/1422-0067/20/8/1915
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http://dx.doi.org/10.3390/ijms20081915DOI Listing
April 2019
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Co-Delivery of M2e Virus-Like Particles with Influenza Split Vaccine to the Skin Using Microneedles Enhances the Efficacy of Cross Protection.

Pharmaceutics 2019 Apr 18;11(4). Epub 2019 Apr 18.

Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.

It is a high priority to develop a simple and effective delivery method for a cross-protective influenza vaccine. We investigated skin immunization by microneedle (MN) patch with human influenza split vaccine and virus-like particles containing heterologous M2 extracellular (M2e) domains (M2e5x virus-like particles (VLP)) as a cross-protective influenza vaccine candidate. Co-delivery of influenza split vaccine and M2e5x VLP to the skin by MN patch was found to confer effective protection against heterosubtypic influenza virus by preventing weight loss and reducing lung viral loads. Read More

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http://dx.doi.org/10.3390/pharmaceutics11040188DOI Listing

MicroRNA-Based Diagnosis and Treatment of Metastatic Human Osteosarcoma.

Cancers (Basel) 2019 Apr 18;11(4). Epub 2019 Apr 18.

Division of Pathological Biochemistry, Tottori University Faculty of Medicine, Yonago, Tottori 683-8503, Japan.

Osteosarcoma is a malignant tumor of the bones that commonly occurs in young individuals. The 5-year survival rate of osteosarcoma patients is 60-70%. Metastasis to the lungs leads to death in 30-40% of osteosarcoma patients. Read More

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https://www.mdpi.com/2072-6694/11/4/553
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http://dx.doi.org/10.3390/cancers11040553DOI Listing
April 2019
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Effect of glycolysis inhibition by miR-448 on glioma radiosensitivity.

J Neurosurg 2019 Apr 19:1-9. Epub 2019 Apr 19.

4Department of Neurosurgery, The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, People's Republic of China.

OBJECTIVEAlthough glucose metabolism reengineering is a typical feature of various tumors, including glioma, key regulators of glycolytic reprogramming are still poorly understood. The authors sought to investigate whether glycolysis inhibition by microRNA (miR)-448 increases radiosensitivity in glioma cells.METHODSThe authors used glioma tissue samples from glioma patients, cells from glioblastoma (GBM) cell lines and normal human astrocyte cells, and subcutaneous tumor-bearing U87 cells in mice to examine the effects of signaling regulation by miR-448 in the response of glioma tissues and cells to radiation treatment. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2018.12.JNS181798DOI Listing
April 2019
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Cisplatin: The first metal based anticancer drug.

Authors:
Sumit Ghosh

Bioorg Chem 2019 Apr 11;88:102925. Epub 2019 Apr 11.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India. Electronic address:

Cisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways which finally lead to apoptosis. However, side effects and drug resistance are the two inherent challenges of cisplatin which limit its application and effectiveness. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.102925DOI Listing
April 2019
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The skeletal renin-angiotensin system: A potential therapeutic target for the treatment of osteoarticular diseases.

Int Immunopharmacol 2019 Apr 16;72:258-263. Epub 2019 Apr 16.

Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China.

The classical renin-angiotensin system (RAS) is known to be a key regulator of blood pressure as well as fluid and electrolyte homeostasis. Additionally, it is now evident that components of the RAS are produced and act locally in many tissues, including liver, kidney, heart, lung, eye, bone, reproductive organ, adipose, and adrenal tissue, and these components are collectively known as tissue RAS. Recently, several studies have shown that local bone RAS is directly involved in bone metabolism, and activation of skeletal RAS plays an important role in bone diseases, such as osteoporosis, arthritis, and deterioration as well as in fracture healing. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.023DOI Listing
April 2019
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