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J Endocr Soc 2022 Jul 3;6(7):bvac083. Epub 2022 Jun 3.

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Acromegaly due to ectopic secretion of growth hormone-releasing hormone (GHRH) is rare. Treatment consists of surgical removal of the primary tumor, cytostatic therapy, "cold" or radioactive somatostatin analogue treatment, and medical therapy for acromegaly, if needed. A 53 year-old female had an ocular lesion noted on a routine optician visit, originally considered to be an ocular melanoma. Read More

J Nucl Med 2022 May 19. Epub 2022 May 19.

Nuclear Medicine and Molecular Imaging, Institut de Cancérologie Strasbourg Europe (ICANS), France.

To compare the respective value of Ga-DOTATOC and F-DOPA PET/CT for initial staging or pre-surgical work-up of patients with small intestine neuroendocrine tumors (SiNET). This is a retrospective, multicenter, non-interventional investigation involving 53 non-operated SiNET patients who underwent both Ga-DOTATOC and F-DOPA PET/CT within a 6-months interval without therapeutic intervention or change between the two PET/CT studies. Detection rate (DR %) was calculated according to per-region and per-lesion analyses. Read More

BMJ Case Rep 2022 05 11;15(5). Epub 2022 May 11.

Onco-Anaesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.

Medicina (B Aires) 2022 ;82(2):297-299

Servicio de Cirugía Torácica, Hospital Británico de Buenos Aires, Argentina.

Lung tumorlets are rare neuroendocrine neoplasms of 0.5 cm or less in diameter that extend beyond the basement membrane. Although they are associated with bronchiectasis and fibrosis they tend to be asymptomatic and behave in a benign way, usually being diagnosed as incidental microscopic nests of neuroendocrine cells in lung tissue. Read More

Biomedicines 2022 Feb 24;10(3). Epub 2022 Feb 24.

Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.

Secretin was originally discovered as a gastrointestinal peptide that stimulates fluid secretion from the pancreas and liver and delays gastric emptying. In disease, a secretin receptor (SCTR) was found to occur as a splice variant in gastrinoma and pancreatic adenocarcinoma. Overexpression of SCTR has been described for gastrinomas, carcinoid tumors of the lung and cholangiocarcinoma. Read More

Eye (Lond) 2022 Mar 19. Epub 2022 Mar 19.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Metastasis to the eye can involve the choroid (90%), ciliary body (2%), iris (8%), and retina, optic disc, vitreous, and/or lens capsule (<1-4%). The mean number of uveal metastasis per eye (1.7), mean tumour base (11. Read More

Port J Card Thorac Vasc Surg 2021 Jul 2;28(2):61-3. Epub 2021 Jul 2.

Service of Pulmonology, Instituto Português de Oncologia do Porto, Portugal.

Primary carcinoid tumours of the lung are rare tumours and when typical are associated with a benign behaviour and should be classified as low-grade neuroendocrine tumour/carcinoma. A 67-year old HIV-positive female was admitted due to a typical carcinoid tumour on the distal third of the main left bronchus, occupying two thirds of the lumen. Given she was HIV positive, had a moderately compromised lung function and in order to minimize surgical events, postoperative complications and to maximize postoperative lung function, the authors opted for a bronchoplasty using a patch. Read More

Anticancer Res 2022 Mar;42(3):1345-1350

Department of Surgery, University of California, San Diego, CA, U.S.A.

Background/aim: Radiofrequency ablation (RFA) is used to treat primary and metastatic tumors in the liver. However, local recurrence after RFA is frequent and subsequent salvage hepatectomy is often ineffective due to difficulty in visualization of tumor margins.

Patients And Methods: In the present retrospective clinical trial, seven patients from the Department of General and Gastro-enterological Surgery, Showa University School of Medicine underwent salvage hepatectomy for recurrent hepatocellular carcinoma (HCC) (n=2), colorectal liver metastasis (n=4) and lung-carcinoid liver metastasis (n=1), after RFA, between 2011 and 2020. Read More

Cureus 2022 Jan 27;14(1):e21657. Epub 2022 Jan 27.

Hematology and Oncology, Christus Highland Medical Center, Shreveport, USA.

The ampulla of Vater is a unique, highly vascularized pouch. Its anatomic transition is halfway along the second part of the duodenum from the foregut to the midgut. According to the World Health Organization's (WHO) latest nomenclature, carcinoid tumors are now called neuroendocrine tumors (NETs). Read More

BJR Case Rep 2021 Jul 12;7(4):20200201. Epub 2021 Apr 12.

Department of Radiology, National Institute of Oncology, Mohammed V University, Rabat, Morocco.

Hepatic metastases from carcinoid tumours are typically solid, hypervascular lesions on imaging. The cystic form, mimicking an abscess, is extremely rare. We report a case of a 48-year-old female presenting with a large hepatic mass that was diagnosed as a hepatic abscess, but the ultrasound-guided biopsy showed well-differentiated grade 1 neuroendocrine tumour. Read More

Medicina (B Aires) 2022 ;82(1):154-158

Servicio de Oncología, Hospital de Rehabilitación Respiratoria María Ferrer, Buenos Aires, Argentina.

Diffuse idiopathic hyperplasia of neuroendocrine cells is an extremely rare condition. It is a widespread proliferation of neuroendocrine cells, without primary process justifying it. Usually symptomatic in most cases, asymptomatic forms are also described. Read More

Case Rep Pulmonol 2021 10;2021:6312296. Epub 2021 Dec 10.

Division of Pulmonary and Critical Care, St. Luke's University Health Network, Bethlehem, PA, USA.

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is an atypical pulmonary disorder with limited understanding. Given the rare nature of this disease, it is essential to obtain adequate tissue pathology to confirm the diagnosis. This disease is mainly diagnosed in middle-aged, nonsmoking females, and it is now accepted as a precursor lesion to pulmonary carcinoid tumors. Read More

Semin Ultrasound CT MR 2021 Dec 7;42(6):524-534. Epub 2021 May 7.

University of Kansas Medical Center, Department of Radiology, Kansas City, KS.

Imaging plays an essential role in the diagnosis and staging of pulmonary malignancy. Familiarity of less common manifestations of lung cancer including subsolid nodule, consolidation, and cyst associated lung cancer is important to avoid delayed diagnosis and improve patient outcomes. In this article, we review the staging of multifocal lung cancer, PET negative lung cancers (carcinoid and indolent lung adenocarcinoma), and false positive lymph nodes on PET due to infectious and inflammatory etiologies. Read More

J Cardiothorac Vasc Anesth 2022 Aug 29;36(8 Pt A):2793-2802. Epub 2021 Oct 29.

Department of Anesthesiology, The Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY.

Neurologist 2021 Nov 26;27(2):37-40. Epub 2021 Nov 26.

Department of Neurology, Hartford Hospital and University of Connecticut School of Medicine, Hartford, CT.

Background: Stroke in the setting of three-territory lesion pattern on magnetic resonance-diffusion-weighted imaging "three-territory sign" (TTS) is predominately due to cancer-associated hypercoagulation (CAH). Our goal is to determine the frequency with which "TTS" is overlooked as a diagnostic feature of cancer-associated hypercoagulation stroke.

Methods: Over a 4-year period (October 2016 to October 2020), stroke admissions with magnetic resonance imaging defined three-territory diffusion-weighted imaging lesions were identified. Read More

Eur Respir J 2022 01 27;59(1). Epub 2022 Jan 27.

Stanford University School of Medicine, Division of Oncology, Dept of Medicine, Stanford, CA, USA

Indian J Thorac Cardiovasc Surg 2021 Nov 21;37(6):676-679. Epub 2021 Apr 21.

Department of Pathology, AIIMS, New Delhi, 110029 India.

Pulmonary sclerosing pneumocytoma is a rare benign neoplasm of the lung, commonly occurs in middle-aged persons with a marked female predominance. Earlier, it was known as sclerosing hemangioma. Here, we present a case of pulmonary sclerosing pneumocytoma which was diagnosed as carcinoid of the lung, based on imaging, in a 14-year-old female. Read More

J Cardiothorac Surg 2021 Oct 16;16(1):302. Epub 2021 Oct 16.

Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.

Background: Video-assisted thoracic surgery sleeve resection with bronchial anastomosis or bronchoplasty is a technically demanding procedure. Three-dimensional endoscopic surgery has been reported to be helpful in decreasing operation time and improving spatial perception with less surgical errors, but there have been rare reports about relatively difficult thoracoscopic procedures utilizing 3D thoracoscope. We performed this study to evaluate early clinical outcomes of thoracoscopic sleeve resection and bronchoplasty utilizing 3D thoracoscope. Read More

J Med Case Rep 2021 Oct 11;15(1):514. Epub 2021 Oct 11.

Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Ectopic adrenocorticotropic hormone secretion syndrome occurs in 10% of all patients with adrenocorticotropic-hormone-dependent hypercortisolism. It is usually associated with overt malignancies or with occult and indolent tumors. This study aims to confirm the source of ectopic adrenocorticotropic hormone in four patients with ectopic Cushing's syndrome over time. Read More

Brain Sci 2021 Aug 25;11(9). Epub 2021 Aug 25.

Department of Human Neurosciences, Division of Neurosurgery, Policlinico Umberto I University Hospital, Sapienza, University of Rome, 00161 Rome, Italy.

Intramedullary spinal cord metastases (ISCMs) are infrequent lesions. Their incidence is estimated to range from 0.9 to 2. Read More

Rev Prat 2021 06;71(6):643

Service de pneumologie et centre de référence constitutif des maladies pulmonaires rares, AP-HP, hôpital Bichat, Paris, France.

Adv Exp Med Biol 2022 ;1374:17-25

Department of Thoracic Surgery, Martha - Maria Hospital Halle - Dölau, Halle, Germany.

Carcinoids are malignant neuroendocrine neoplasms showing good long-term survival after oncologic therapy. The study evaluated the influence of operative strategies and individual decision-making on the outcome and long-term survival in 222 patients with bronchial carcinoids. The patients underwent preoperative pulmonary function tests and bronchoscopy to facilitate surgical decision-making. Read More

Asian Cardiovasc Thorac Ann 2022 02 22;30(2):215-216. Epub 2021 Sep 22.

Department of Thoracic Surgery, 107736Mohammed V Military Teaching Hospital, Rabat, Morocco.

Diagn Cytopathol 2021 Dec 7;49(12):E471-E474. Epub 2021 Sep 7.

Department of Pathology and Laboratory Medicine, Cooper University Hospital, Camden, New Jersey, USA.

The prevalence of ectopic thyroid tissue, based on autopsy studies, is between 7% and 10%, but there are rare cases reported in the thoracic region. Here, we encountered a case of thoracic ectopic thyroid tissue presenting as a presumed enlarged mediastinal lymph node. A 50-year-old female with a history of lung adenocarcinoma, status post resection, presented with complaints of headache, dizziness, and nausea. Read More

Transl Biophotonics 2020 Nov 21;2(4):e202000009. Epub 2020 Aug 21.

Faculty of Science, Department of Physics, LaserLab Vrije Universiteit Amsterdam Amsterdam Netherlands.

During lung cancer operations a rapid and reliable assessment of tumor tissue can reduce operation time and potentially improve patient outcomes. We show that third harmonic generation (THG), second harmonic generation (SHG) and two-photon excited autofluorescence (2PEF) microscopy reveals relevant, histopathological information within seconds in fresh unprocessed human lung samples. We used a compact, portable microscope and recorded images within 1 to 3 seconds using a power of 5 mW. Read More

Cureus 2021 Jun 27;13(6):e15977. Epub 2021 Jun 27.

Department of Internal Medicine, Presbyterian Medical Center, Albuquerque, USA.

Diagnosis of synchronous multiple primary lung cancers (SMPLCs) is a challenge as multiple lesions on chest CT imaging can be misdiagnosed as more common entities such as metastatic disease or infections. The possibility of multiple primary lung cancers should always be considered. Accurate diagnosis can significantly change the management and prognosis. Read More

Front Endocrinol (Lausanne) 2021 9;12:687539. Epub 2021 Jul 9.

Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.

Background: Ectopic adrenocorticotropic syndrome (EAS) is a rare cause of endogenous ACTH-dependent Cushing's syndrome, usually associated with severe hypercortisolism as well as comorbidities. Tumor detection is still a challenge and often requires several imaging procedures. In this report, we describe a case of an ectopic ACTH secretion with a misleading localization of the responsible tumor due to a concomitant rectal carcinoma. Read More

Clin Nucl Med 2022 Jan;47(1):56-58

From the Department of Radiology and Imaging Sciences, University of Utah School of Medicine, Salt Lake City, UT.

Abstract: Pineal region metastases are very rare, occurring in 0.4% to 3.8% of patients with solid tumors and most frequently arise from a lung cancer primary tumor. Read More

Cancer Biother Radiopharm 2021 Oct 12;36(8):632-641. Epub 2021 Jul 12.

Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.

Histone deacetylase (HDAC) inhibitors have been shown in preclinical studies to upregulate norepinephrine transporters in neuroblastoma and pheochromocytoma, and somatostatin receptors in pulmonary carcinoid, small cell lung cancer, and pancreatic neuroendocrine malignancies. This pilot imaging study in humans focuses on midgut neuroendocrine carcinoma metastatic to the liver, evaluating the effect of pretreatment with the HDAC inhibitor vorinostat on uptake of I-MIBG and Ga-DOTATOC. Multiple midgut neuroendocrine liver metastases in clinically stable subjects were imaged with I-MIBG and Ga-DOTATOC before and after a 4-d course of vorinostat. Read More

Chest 2021 07;160(1):e51-e56

Department of Pathology, Albany Medical Center, Albany, NY.

Case Presentation: A 75-year-old woman was referred to the pulmonary office in January 2020 for cough and progressive worsening of shortness of breath over the years. Her medical history was significant for asthma that was diagnosed approximately 10 years earlier, when she first developed dyspnea. A pre-bronchodilator spirometry at that time showed severe airflow obstruction (Fig 1). Read More