737 results match your criteria Lung Carcinoid Imaging


The role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a Position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC).

Eur J Heart Fail 2020 Jul 4. Epub 2020 Jul 4.

National Heart and Lung Institute, Imperial College, London, United Kingdom.

Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the ESC have evaluated the current evidence for the value of modern CV imaging in the cardio-oncology field. Read More

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http://dx.doi.org/10.1002/ejhf.1957DOI Listing

Diagnostic accuracy of sentinel lymph node biopsy using indocyanine green in lung cancer: a systematic review and meta-analysis.

Gen Thorac Cardiovasc Surg 2020 Jun 16. Epub 2020 Jun 16.

Division of General Surgery, Walter C. Mackenzie Health Sciences Centre, University of Alberta, 8440 - 112 ST NW, Edmonton, AB, 2G2 T6G 2B7, Canada.

Objective: The use of sentinel lymph node biopsy (SLNB) has been gaining popularity with the emergence of indocyanine green (ICG) fluorescence imaging. We aimed to systematically review the literature and perform a meta-analysis on the diagnostic accuracy of SLNB using ICG for lung cancer.

Methods: A comprehensive search of MEDLINE, EMBASE, SCOPUS, Web of Science, and the Cochrane Library using search terms "lung/pulmonary" AND "tumor/carcinoma/cancer/neoplasm/adenocarcinoma/malignancy/squamous/carcinoid" AND "indocyanine green" was completed in June 2018. Read More

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http://dx.doi.org/10.1007/s11748-020-01400-8DOI Listing

Review of Nonmammary Metastases to the Breast: Imaging and Clinical Presentation.

Curr Probl Diagn Radiol 2020 May 17. Epub 2020 May 17.

Department of Radiology, Mayo Clinic, Rochester, MN.

Objectives: The purpose of our study is to review the imaging findings of breast metastases from nonmammary sources at our institution and to explore the mode of initial detection of these breast metastases.

Methods: In this study, we reviewed our electronic medical record and our breast imaging database for all patients who presented with nonmammary metastases to breasts between 5/1/2009 and 12/1/2019. We reviewed all available imaging data, clinical notes, and pathology reports. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2020.04.010DOI Listing

Primary tumor standardized uptake value (SUVmax) measured on F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer.

J Cancer Res Clin Oncol 2020 Jun 3. Epub 2020 Jun 3.

Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, People's Republic of China.

Purpose: The combined small-cell lung cancer (c-SCLC) is rare and has unique clinicopathological futures. The aim of this study is to investigate F-FDG PET/CT parameters and clinicopathological factors that influence the prognosis of c-SCLC.

Methods: Between November 2005 and October 2014, surgical-resected tumor samples from c-SCLC patients who received preoperative F-FDG PET/CT examination were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00432-020-03240-8DOI Listing

Lung Cancer And Radiological Imaging.

Curr Radiopharm 2020 May 23. Epub 2020 May 23.

Ospedale San Giovanni e Paolo, ULSS 3 Veneziana, Venezia. Italy.

Background: Lung cancer is the neoplasm with the highest prevalence and mortality rates in the world. Most patients with lung cancer that are symptomatic have hemoptysis, coughing, shortness of breath, chest pain and persistent infections. Less than 10% of patients are asymptomatic when the tumor is detected as an incidental finding. Read More

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http://dx.doi.org/10.2174/1874471013666200523161849DOI Listing

Novel Findings on SPECT-CT Tc-99 Sestamibi Imaging for Primary Hyperparathyroidism.

J Surg Res 2020 Aug 11;252:216-221. Epub 2020 Apr 11.

Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:

Background: The addition of SPECT-CT to Tc-99 sestamibi has become a valuable tool for parathyroid localization in primary hyperparathyroidism (PHP). However, the enhanced sensitivity of this test can lead to unexpected and significant findings. We sought to identify the frequency and types of nonparathyroid detections by SPECT-CT. Read More

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http://dx.doi.org/10.1016/j.jss.2020.03.014DOI Listing

A primary neuroendocrine tumor of the left ventricle presenting with diarrhea-an unusual experience and literature review.

Diagn Pathol 2020 Apr 3;15(1):32. Epub 2020 Apr 3.

Department of Pathology, The Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.

Background: Neuroendocrine tumors (NETs) can secrete bioactive amines in the bloodstream, resulting in the carcinoid syndrome characterized by diarrhea and flushing. The frequency of occurrence of primary cardiac neuroendocrine neoplasms is lesser than that of metastases, and hence, metastases must be adequately ruled out before diagnosis. Cardiac tumors, both primary and metastatic, mainly result in heart-related symptoms, such as heart failure and acquired valvular dysfunction. Read More

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http://dx.doi.org/10.1186/s13000-020-00935-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119177PMC

Clinicopathological characteristics and genetic analysis of pulmonary carcinoid tumors: A single-center retrospective cohort study and literature review.

Oncol Lett 2020 Mar 24;19(3):2446-2456. Epub 2020 Jan 24.

Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.

Pulmonary carcinoid tumors, including typical and atypical carcinoids, are well-differentiated neuroendocrine tumors (NETs) that represent 1-2% of all lung cancer cases. In the present study, all cases of well-differentiated NETs diagnosed at Tianjin Medical University General Hospital (Tianjin, China) between 2006 and 2016 were reviewed, and 20 pulmonary carcinoid cases were identified. The clinical features of these cases were summarized, and the results of pathological and imaging examinations were collated. Read More

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http://dx.doi.org/10.3892/ol.2020.11347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039106PMC

Diagnostic imaging of typical lung carcinoids: relationship between MDCT, In-Octreoscan and F-FDG-PET imaging features with Ki-67 index.

Radiol Med 2020 Aug 18;125(8):715-729. Epub 2020 Mar 18.

Department of Radiology, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134, Florence, Italy.

Aims: This study analyses the capability of contrast-enhanced multi-detector computed tomography (MDCT) and spectrum of molecular imaging to characterize typical carcinoids (TCs) of lung and their relationship with Ki-67 index.

Materials And Methods: We analysed 68 patients with histological diagnosis of pulmonary TC, which underwent both MDCT and nuclear molecular imaging (somatostatin receptor scintigraphy/SPECT with In-pentetreotide and F-FDG-PET/CT) at staging evaluation before surgery. The MDCT scan was reviewed for the following features: size, margins, contrast enhancement, presence of calcifications, bronchial obstruction, lymph nodes and metastases. Read More

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http://dx.doi.org/10.1007/s11547-020-01172-4DOI Listing

Neuroendocrine metastases to the ovaries are significantly associated with small bowel neuroendocrine tumors and carcinomatosis.

Am J Surg 2020 05 25;219(5):795-799. Epub 2020 Feb 25.

Division of Surgical Oncology, Oregon Health & Science University, USA. Electronic address:

Introduction: Neuroendocrine tumors (NETs) metastatic to the ovary are traditionally considered rare, but data are lacking. This study seeks to better characterize the prevalence and outcomes of patients with neuroendocrine ovarian metastases (NOM).

Methods: Women with well-differentiated lung and gastroenteropancreatic NETs 2007-2017 were identified by medical record query. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.02.040DOI Listing

An ectopic Cushing's syndrome as a cause of severe refractory hypokalemia in the ICU.

Acta Clin Belg 2020 Feb 23:1-6. Epub 2020 Feb 23.

Department of Intensive Care, Brugmann University Hospital, Brussels, Belgium.

: Ectopic Cushing's syndrome is a very rare condition caused by an ACTH-secreting tumor outside the pituitary or adrenal glands, and the majority of these cases are encountered in the context of paraneoplastic syndromes. The ectopic source of ACTH secretion is not always obvious to detection and can be challenging. We report a rare case, in which a hidden ACTH-secreting carcinoid tumor of the lung caused a severe refractory hypokalemia, leading us to a race against time to locate the tumor. Read More

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http://dx.doi.org/10.1080/17843286.2020.1734162DOI Listing
February 2020

99mTc-EDDA/HYNIC-TOC is a new opportunity in Neuroendocrine Tumors of the Lung (and in other malignant and benign pulmonary diseases) .

Curr Radiopharm 2019 Dec 30. Epub 2019 Dec 30.

Section Health and Development, Interuniversity Research Center for Sustainability (CIRPS), Napoli, Italy.

Neuroendocrine tumors (NETs) consist of a relatively rare spectrum of malignancies that can arise from neuroendocrine cells; lung NETs (L-NETs) represent about 25% of primary lung neoplasm and 10% of all carcinoid tumors. Diagnostic algorithm usually takes into consideration chest X-ray, contrast-enhanced CT and MRI. Nuclear medicine plays a crucial role in the detection and correct assessment of neoplastic functional status as it provides in vivo metabolic data related to the over-expression of Somatostatin Receptors (SSTRs) and also predicting response to peptide receptor radionuclide therapy (PRRT). Read More

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http://dx.doi.org/10.2174/1874471013666191230143610DOI Listing
December 2019

A typical carcinoid of the lung - a case report with pathological correlation and propagation of the cancer stem cell line BKZ1 with synaptophysin expression.

Medicine (Baltimore) 2019 12;98(49):e18174

Department of General Thoracic Surgery, Protestant Hospital of Bethel Foundation, Burgsteig 13.

Rationale: Neuroendocrine tumors (NETs) of the lung account for 5% of all cases of lung cancer, which itself is the leading cause of cancer-related death worldwide. In accordance to its rarity, only few cell lines of NETs exist, which even often lack key characteristics of the primary tumor, making it difficult to study underlying molecular mechanisms.

Patient Concerns: The patient reported in this case is a 71-year old woman, which never smoked but suffered under dry cough. Read More

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http://dx.doi.org/10.1097/MD.0000000000018174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919531PMC
December 2019

A rare case of pulmonary typical carcinoid with prominent acinic cell differentiation, resembling acinic cell carcinoma.

Pathol Int 2019 Dec 14;69(12):721-726. Epub 2019 Nov 14.

Departments of Surgical Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

We herein describe a rare case of low-grade endobronchial tumor that exhibited two distinct features of typical carcinoid and acinic cell carcinoma (ACC) by immunohistochemical and ultrastructure study. ACC was suspected on transbronchial biopsy. The resected specimen showed that the tumor surface comprised an acinic cell component (40% of the tumor), and the central area comprised typical carcinoid (60% of the tumor). Read More

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http://dx.doi.org/10.1111/pin.12869DOI Listing
December 2019

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: Review of the Literature and a Single-center Experience.

Cureus 2019 Sep 13;11(9):e5640. Epub 2019 Sep 13.

Pathology, Hospital Universitario De Torrejón, Madrid, ESP.

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare disorder that is commonly underdiagnosed. In 2015, it was recognized by the World Health Organization (WHO) classification of lung tumors as a premalignant lesion. DIPNECH syndrome is characterized by cough, exertional dyspnea, wheezing, and, less frequently, hemoptysis. Read More

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http://dx.doi.org/10.7759/cureus.5640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822881PMC
September 2019

PET-CT for Evaluating Breast Cancer Yields Incidental Finding in the Lung.

Radiol Technol 2019 Nov;91(2):120-125

Background: A woman aged 75 years presented with a palpable left axillary lymph node. Mammography showed a spiculated mass in the left breast, demonstrated by biopsy to be triple-negative breast cancer. A positron emission tomography-computed tomography (PET-CT) scan was performed to evaluate the extent of the cancer and revealed an unrelated nonmetastatic, synchronous carcinoid in the left lung. Read More

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November 2019
1 Read

[Pulmonary carcinoids and carcinoids of the small intestine].

Radiologe 2019 Nov;59(11):968-974

Klinik und Poliklinik für Radiologie, Klinikum der Universität München, LMU München, Marchioninistraße 15, 81377, München, Deutschland.

Clinical/methodical Issue: Pulmonary carcinoids and carcinoids of the small intestine (jejunum and ileum) are often asymptomatic and can affect various parts of the body, which makes diagnosis difficult.

Standard Radiological Methods: Contrast-enhanced computed tomography (CE-CT) is commonly used for primary diagnostics. In case of concomitant pulmonary consolidation (e. Read More

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http://dx.doi.org/10.1007/s00117-019-00597-xDOI Listing
November 2019
2 Reads

Adrenocorticotropic Hormone-Secreting, Subcentimetre Lung Carcinoid Identified by 68Gallium-DOTATATE Positron Emission Tomography Scan.

Authors:
Run Yu

Sultan Qaboos Univ Med J 2019 May 8;19(2):e166-e167. Epub 2019 Sep 8.

Division of Endocrinology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.18295/squmj.2019.19.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736268PMC

Atypical diagnosis for typical lung carcinoid.

BMC Pulm Med 2019 Sep 2;19(1):168. Epub 2019 Sep 2.

Respiratory Diseases Unit, Azienda Unità Sanitaria Locale - IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Viale Risorgimento 80, 42123, Reggio Emilia, Italy.

Background: The diagnosis of lung typical carcinoid tumors results challenging when limited size and unfavorable sampling location is associated. It has been reported that bronchoscopy with endobronchial ultrasound (EBUS) significantly increases the diagnostic yield of peripheral nodules smaller than 2 cm.

Case Presentation: A 70-year-old Caucasian male complained of persistent fever and cough despite several antibiotic courses and steroid treatment. Read More

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http://dx.doi.org/10.1186/s12890-019-0929-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719370PMC
September 2019
5 Reads

Capecitabine and Temozolomide in Advanced Lung Neuroendocrine Neoplasms.

Oncologist 2020 01 27;25(1):e48-e52. Epub 2019 Aug 27.

Department of GI Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

Background: Patients with advanced lung neuroendocrine neoplasms (NENs) have few treatment options. Capecitabine and temozolomide have recently showed significant activity in patients with pancreatic neuroendocrine tumors (NETs), but data in lung NETs are limited.

Methods: We retrospectively reviewed the records of patients treated at a large referral center to identify patients seen between January 2008 and September 2018 with metastatic lung NENs who received treatment with capecitabine and temozolomide (CAPTEM). Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964126PMC
January 2020
4 Reads

Simultaneous diagnosis of glioblastoma, cervical schwannoma, adrenal masses and growth hormone-secreting adenoma in a previously healthy patient.

BMJ Case Rep 2019 Aug 21;12(8). Epub 2019 Aug 21.

Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

A constellation of newly diagnosed benign tumours and glioblastoma is an uncommon occurrence in a single individual. We present a case of a patient with a history of skin lipomas who presented with seizures and was found to have a left frontotemporal multifocal enhancing mass on MRI. Work-up for metastatic disease revealed a benign lung carcinoid tumour, a cervical schwannoma, adrenal masses, a growth hormone-secreting pituitary adenoma, and lastly a glioblastoma following brain biopsy. Read More

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http://dx.doi.org/10.1136/bcr-2019-229675DOI Listing
August 2019
6 Reads

Tumor-to-Tumor Metastasis: Pulmonary Carcinoid Metastasizing to Solitary Fibrous Tumor.

Am J Case Rep 2019 Aug 15;20:1205-1209. Epub 2019 Aug 15.

Department of General Thoracic Surgery, Kobe City Medical Centre General Hospital, Kobe, Hyogo, Japan.

BACKGROUND Tumor-to-tumor metastasis is an uncommon phenomenon in which a primary tumor metastasizes into another tumor. CASE REPORT An 81-year-old Asian woman was referred to our hospital for evaluation and treatment of a solid mass in the right middle lung lobe that had rapidly enlarged for 1.5 years compared to that observed over the last 5 years. Read More

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http://dx.doi.org/10.12659/AJCR.917139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705342PMC
August 2019
2 Reads

Pulmonary embolism as the presenting symptom and a confounder in ACTH-secreting bronchial carcinoid

Endocrinol Diabetes Metab Case Rep 2019 Jul 26;2019(1). Epub 2019 Jul 26.

Division of Endocrinology, Department of Internal Medicine

Summary: Ectopic ACTH-secreting pulmonary neuroendocrine tumors are rare and account for less than 5% of endogenous Cushing’s syndrome cases. We describe an unusual case of metastatic bronchial carcinoid tumor in a young woman presenting with unprovoked pulmonary emboli, which initially prevented the detection of the primary tumor on imaging. The source of ectopic ACTH was ultimately localized by a Gallium-DOTATATE scan, which demonstrated increased tracer uptake in a right middle lobe lung nodule and multiple liver nodules. Read More

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http://dx.doi.org/10.1530/EDM-19-0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685091PMC
July 2019
4 Reads

68Ga-DOTATATE PET/CT in Focal Fatty Sparing of the Liver.

Clin Nucl Med 2019 Oct;44(10):815-817

From the Institute of Nuclear Medicine and Molecular Imaging.

Ga-DOTATATE imaging is commonly used for the detection of metastatic disease in neuroendocrine tumors. We present a case of a 69-year-old woman postsurgery for lung carcinoid tumor in which sequential follow-up Ga-DOTATATE PET/CT studies identified focal hepatic uptake that was presumed to represent a liver metastasis. However, correlative imaging with MRI revealed a focal fatty sparing of the liver composed of benign hepatic parenchyma at that area accompanied with diffuse liver steatosis in the background of the "pseudolesion. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002746DOI Listing
October 2019
3 Reads

Imaging Characteristics of Coexisting Primary Pulmonary Carcinoid Tumor and Multiple Myeloma on 18F-FDG and 68Ga-DOTATATE PET/CT.

Authors:
Yang Lu

Clin Nucl Med 2019 Nov;44(11):914-915

From the Department of Nuclear Medicine, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas.

A 69-year-old man with recurrent multiple myeloma underwent FDG PET/CT evaluation. A pulmonary nodule without higher-than-background FDG avidity was later biopsied as a low-grade neuroendocrine tumor. On further Ga-DOTATATE PET/CT evaluation of patient's neuroendocrine tumor, the lytic myeloma lesions revealed only mild DOTATATE avidity while the primary pulmonary neuroendocrine tumor showed intense DOTATATE uptake. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002706DOI Listing
November 2019
3 Reads
3.931 Impact Factor

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) with liver metastases.

BMJ Case Rep 2019 Jun 24;12(6). Epub 2019 Jun 24.

Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) is a rare pulmonary disorder characterised by classic radiological findings and symptoms of obstructive lung disease. DIPNECH is considered a precursor to carcinoid tumours in the lungs. In this case, we describe a patient with years of unexplained dry cough presenting with 2 weeks of progressive nausea and vomiting, and found to have massive hepatomegaly on examination. Read More

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http://dx.doi.org/10.1136/bcr-2018-228536DOI Listing
June 2019
5 Reads

Pulmonary Carcinoid Surface Receptor Modulation Using Histone Deacetylase Inhibitors.

Cancers (Basel) 2019 Jun 3;11(6). Epub 2019 Jun 3.

Department of Surgery, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

Pulmonary carcinoids are a type of neuroendocrine tumor (NET) accounting for 1-2% of lung cancer cases. Currently, Positron Emission Tomography (PET)/CT based on the radiolabeled sugar analogue [F]-FDG is used to diagnose and stage pulmonary carcinoids, but is suboptimal due to low metabolic activity in these tumors. A new technique for pulmonary carcinoid imaging, using PET/CT with radiolabeled somatostatin analogs that specifically target somatostatin receptor subtype 2 (SSTR2), is becoming more standard, as many tumors overexpress SSTR2. Read More

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http://dx.doi.org/10.3390/cancers11060767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627607PMC
June 2019
13 Reads

Use of 3-dimensional computed tomography for planning a complex sleeve bronchoplasty with total parenchyma-sparing resection of a carcinoid tumour in the right main bronchus.

Interact Cardiovasc Thorac Surg 2019 10;29(4):638-640

Department of Thoracic Surgery and Lung Transplantation, Foch Hospital, Suresnes, France.

Bronchoplasty is frequently required for radical resection of central typical carcinoid tumours. As sleeve bronchoplasty can be a complex procedure, an accurate evaluation of the tumour location is mandatory. Although the endobronchial part of the tumour can be easily evaluated by bronchoscopy, the exo-bronchial part is difficult to analyse with a standard computed tomography (CT) scan. Read More

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https://academic.oup.com/icvts/advance-article/doi/10.1093/i
Publisher Site
http://dx.doi.org/10.1093/icvts/ivz124DOI Listing
October 2019
14 Reads

Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence.

Lung Cancer 2019 06 5;132:141-149. Epub 2019 Apr 5.

Department of Gastrointestinal Surgery, Rigshospitalet, Copenhagen, Denmark; Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark; ENETS Neuroendocrine Tumour Centre of Excellence Rigshospitalet, University of Copenhagen, Denmark.

Background: Bronchopulmonary neuroendocrine tumours are divided into typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC), and small cell lung cancer (SCLC).

Aim: To thoroughly describe a cohort of 252 patients with TC, AC and LCNEC (SCLC excluded).

Material And Methods: Collection of data from 252 patients referred to and treated at Rigshospitalet 2008-2016. Read More

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http://dx.doi.org/10.1016/j.lungcan.2019.03.013DOI Listing
June 2019
7 Reads

Cabergoline in severe ectopic or occult Cushing's syndrome.

Eur J Endocrinol 2019 Jul;181(1):K1-K9

Endocrinology Department, 'Groupement Hospitalier Est' Hospices Civils de Lyon, Lyon, France.

Context: Cabergoline has been shown to have some effect in the treatment of moderate Cushing's disease, but its effectiveness in Cushing's syndrome of ectopic or occult origin remains to be investigated.

Case Series: In this case series, cabergoline was used in combination with steroidogenesis inhibitors in nine patients with severe Cushing's syndrome of ectopic or occult origin. Cabergoline's effectiveness enabled rapid withdrawal of the steroidogenesis inhibitors and long-term control of the hypercortisolism in three of the cases. Read More

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http://dx.doi.org/10.1530/EJE-18-1014DOI Listing
July 2019
16 Reads

Carcinoid tumor of lung and BRCA mutation: a case report.

J Med Case Rep 2019 May 1;13(1):132. Epub 2019 May 1.

Internal Medicine Residency Program, Department of Medicine, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ, 07753, USA.

Background: A BRCA mutation is a mutation in either of the BRCA1 or BRCA2 genes, which are tumor suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, whereas others have no proven impact. BRCA mutations are well known to be associated with breast, uterine, and ovarian cancers along with some nongynecological malignancies involving the peritoneum, prostate, pancreas, skin, stomach, and rectum. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13256-019-2052-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492413PMC
May 2019
34 Reads

Ectopic ACTH Syndrome With Association of Multiple Pulmonary Sclerosing Pneumocytomas and Multiple Carcinoid Tumorlets.

J Endocr Soc 2019 May 18;3(5):937-942. Epub 2019 Mar 18.

Department of Medicine, Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia.

We present the case of multiple sclerosing pneumocytomas (SPs) associated with ACTH-secreting carcinoid tumorlets responsible for an ectopic Cushing syndrome (ECS). SP is a rare benign tumor originating from pulmonary epithelial cells. An 18-year-old male presented with shortness of breath and right-sided chest pain after exercise. Read More

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http://dx.doi.org/10.1210/js.2018-00334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469949PMC
May 2019
7 Reads

Spontaneous Partial Regression of a Carcinoid Tumor: Radiology May Not Capture the Real Picture.

Turk Thorac J 2019 04 31;20(2):153-156. Epub 2019 Jan 31.

Department of Pulmonary Medicine, Pacific Medical College and Hospital, Udaipur, Rajasthan, India.

A partial or complete resolution of the neoplastic lesion, either spontaneously or in the presence of therapy that is considered inadequate to exert significant influence on the growth of the neoplastic lesion, is considered a spontaneous regression. This phenomenon is extremely rare in lung neoplasms. A close follow up with imaging along with bronchoscopy and a biopsy of the lesion is essential, as they may have potential for distant spread even during radiological regression. Read More

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http://dx.doi.org/10.5152/TurkThoracJ.2018.18059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453627PMC
April 2019
6 Reads

A case of pseudocystic liver metastases from an atypical lung carcinoid tumor.

Radiol Case Rep 2019 May 6;14(5):595-601. Epub 2019 Mar 6.

Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.

Metastatic neuroendocrine tumors of the liver typically appear as solid, hypervascular masses on imaging. Pseudocysts mimicking simple cysts are extremely rare. A 42-year-old Japanese woman was referred with a single pulmonary mass in the left lower lobe. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406078PMC
May 2019
6 Reads

The utility of 18F-FDG and 68Ga-DOTA-Peptide PET/CT in the evaluation of primary pulmonary carcinoid: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Mar;98(10):e14769

Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

Background: Pulmonary carcinoids (PC) are histologically classified into typical carcinoid (TC) and atypical carcinoid (AC). The diagnosis of pulmonary carcinoid and possibly the differentiation between TC and AC could make a significant effect on the treatment planning as well as prognosis. Several studies have explored the utility of Ga-DOTA-Peptide (Ga-labelled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-peptide) and F-flurodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in the evaluation of primary pulmonary carcinoids. Read More

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http://dx.doi.org/10.1097/MD.0000000000014769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417554PMC
March 2019
12 Reads

Postpneumonectomy-like syndrome due to bronchial carcinoid: a unique case report.

BMC Pulm Med 2019 Feb 18;19(1):44. Epub 2019 Feb 18.

1st Respiratory Medicine Department, University of Athens, "Sotiria" Hospital, 152 Mesogeion Ave, 115 27, Athens, Greece.

Background: Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contralateral hemithorax, mimicking the mediastinal shift observed in postpneumonectomy syndrome after pneumonectomy. We report a unique case of postpneumonectomy-like syndrome caused by an atypical bronchial carcinoid completely occluding the left main bronchus.

Case Presentation: A 25-year-old woman presented with symptoms of chronic exertional dyspnea and productive cough. Read More

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http://dx.doi.org/10.1186/s12890-018-0767-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380005PMC
February 2019
6 Reads

Atypical bronchial carcinoid with postobstructive mycobacterial infection: case report and review of literature.

BMC Pulm Med 2019 Feb 15;19(1):41. Epub 2019 Feb 15.

Department of Pulmonary Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Background: Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low among clinicians. The synchronous presentation of lung cancer and mycobacterial infection is well known but the combination of pulmonary carcinoid and mycobacterial infection is rare. Read More

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http://dx.doi.org/10.1186/s12890-019-0806-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376781PMC
February 2019
11 Reads

Diagnostic performances of 68Ga-DOTATOC versus 18Fluorodeoxyglucose positron emission tomography in pulmonary carcinoid tumours and interrelationship with histological features.

Interact Cardiovasc Thorac Surg 2019 06;28(6):957-960

Unit of Nuclear Medicine, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy.

Few data are available about radio-receptorial positron emission tomography (PET) results by the use of 68Ga-DOTA-peptides in pulmonary carcinoid tumours. In this study, we retrospectively analysed 68Ga-DOTATOC/PET and 18Fluorodeoxyglucose (FDG) PET diagnostic performances in 62 pulmonary carcinoids (occurring in 57 patients) and interrelationship with histological features. All patients underwent at least 1 PET/computed tomography: 26 patients received 68Ga-DOTATOC, 52 patients had 18F-FDG and 20 patients received both techniques. Read More

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http://dx.doi.org/10.1093/icvts/ivz009DOI Listing
June 2019
4 Reads

Comparison of (18F)FDG PET/CT and (68Ga)DOTATATE PET/CT imaging methods in terms of detection of histological subtype and related SUVmax values in patients with pulmonary carcinoid tumors.

Nucl Med Commun 2019 May;40(5):517-524

Department of Nuclear Medicine, Diyarbakir Gazi Yasargil Training and Research Hospital.

Objective: This study was designed to compare the 18-Fluorodeoxyglucose positron emission tomography/computed tomography [(F)FDG PET/CT] and 1,4,7,10-tetraazacyclododecane-NI,NII,NIII,NIIII-tetraacetic acid (D)-Phe1-thy3-octreotate [(Ga)DOTATATE PET/CT) findings in patients with pulmonary carcinoid (PC) tumors.

Materials And Methods: A total of 20 patients [mean (SD) age: 52.2 (12. Read More

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http://Insights.ovid.com/crossref?an=00006231-900000000-9844
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http://dx.doi.org/10.1097/MNM.0000000000000985DOI Listing
May 2019
9 Reads

Somatostatin Receptor Expression Is Associated With Metastasis and Patient Outcome in Pulmonary Carcinoid Tumors.

J Clin Endocrinol Metab 2019 06;104(6):2083-2093

Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Context: Pulmonary carcinoids (PCs) belong to neuroendocrine tumors that often overexpress somatostatin receptors (SSTRs). This overexpression provides a molecular basis for tumor imaging and treatment with somatostatin analogs.

Objective: To evaluate SSTR1 to SSTR5 distribution in a large set of PC tumors and to investigate whether the expression is associated with clinicopathological and outcome data. Read More

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http://dx.doi.org/10.1210/jc.2018-01931DOI Listing
June 2019
40 Reads

NETest Liquid Biopsy Is Diagnostic of Lung Neuroendocrine Tumors and Identifies Progressive Disease.

Neuroendocrinology 2019 17;108(3):219-231. Epub 2019 Jan 17.

University of Warmia and Mazury, Olsztyn, Poland.

Background: There are no effective biomarkers for the management of bronchopulmonary carcinoids (BPC). We examined the utility of a neuroendocrine multigene transcript "liquid biopsy" (NETest) in BPC for diagnosis and monitoring of the disease status.

Aim: To independently validate the utility of the NETest in diagnosis and management of BPC in a multicenter, multinational, blinded study. Read More

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http://dx.doi.org/10.1159/000497037DOI Listing
December 2019
45 Reads

18F-FDG PET/CT and nestin expression as prognostic tools in pulmonary neuroendocrine tumours.

Nucl Med Commun 2019 Apr;40(4):353-360

Departments of Endocrinology, Metabolism and Internal Medicine.

Objectives: The aim of this study was to investigate the fluorine-18-fluorodeoxyglucose (F-FDG) uptake on integrated PET [PET/computed tomography (CT)] images and its correlation with nestin expression in a series of neuroendocrine lung tumours. As the incidence of neuroendocrine lung tumours is rising, tools predicting diagnosis, outcome and assisting in the selection of treatment regimens are needed.

Patients And Methods: We reviewed records of patients diagnosed with large cell neuroendocrine lung carcinoma, atypical carcinoid and typical carcinoid who were operated upon in our institution. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000972DOI Listing
April 2019
5 Reads

Case of Solitary Peritoneal Metastasis From Atypical Bronchopulmonary Carcinoid on 18F-FDG PET/CT.

Clin Nucl Med 2019 Mar;44(3):e154-e157

Department of Histopathology, HCG Cancer Centre, Bangalore, India.

Atypical lung carcinoids frequently metastasize to mediastinal nodes, liver, bone, lungs, and brain and rarely to ovaries, pancreas, subcutaneous, and skin. Solitary peritoneal metastasis is extremely rare and unreported previously. We present a case of a 36-year-old woman with cough, hemoptysis, dyspnea with detection of lung mass, and incidental detection of pelvic mass. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002441DOI Listing
March 2019
11 Reads

Cyclic Cushing's syndrome caused by neuroendocrine tumor: a case report.

Endocr J 2019 Feb 19;66(2):175-180. Epub 2018 Dec 19.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

Cushing's syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing's syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing's syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0168DOI Listing
February 2019
47 Reads

Metastatic thymic carcinoid responds to chemoradiation and octreotide: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13286

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Rationale: Thymic carcinoids are a rare type of malignant neuroendocrine tumors which have a poor prognosis due to their distant metastasis, invasive behaviour, and postoperative recurrence. Surgical resection is still the fundamental mode for treating thymic carcinoids. Here, we report the rapid shrinkage of an atypical thymic carcinoid with multiple metastases following chemoradiation plus octreotide as a first-line therapy PATIENT CONCERNS:: A 39-year-old Chinese man presented with chest tightness, dyspnea with a history of lumbago and untreated malignant thymoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393003PMC
November 2018
46 Reads

Primary Lung Tumors in Children: Radiologic-Pathologic Correlation From the Radiologic Pathology Archives.

Radiographics 2018 Nov-Dec;38(7):2151-2172

From the Department of Radiology and Radiological Sciences (J.P.L., E.M.C.) and Department of Pathology (J.P.L., A.R.H., E.M.C.), Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814; Thoracic Radiology Section (J.P.L., D.M.B.) and Pediatric Radiology Section (D.M.B., E.M.C.), American Institute for Radiologic Pathology, Silver Spring, Md; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pa (D.M.B.); Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Tex (B.W.C.); and Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (M.A.P.).

Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Read More

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http://dx.doi.org/10.1148/rg.2018180192DOI Listing
September 2019
11 Reads

68Ga-DOTATOC PET/CT in Thyroid Metastases of Lung Carcinoid.

Clin Nucl Med 2018 Dec;43(12):e492-e494

Dipartimento di Medicina Sperimentale, Università di Roma "Sapienza".

We report the case of a 43-year-old man with a history of lung carcinoid and a recent detection of thyroid nodules by ultrasound. The cytological analysis raised the suspicion of medullary thyroid carcinoma; however, calcitonin and carcinoembryonic antigen levels were in reference range. Considering the previous diagnosis of lung carcinoid, the patient underwent whole-body Ga-DOTATOC PET/CT. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002331DOI Listing
December 2018
4 Reads

A case of ectopic ACTH syndrome due to DDAVP-sensitive but V1b receptor-negative bronchial typical carcinoid with lymphatic metastasis and plasma ProGRP elevation.

Endocr J 2018 Dec 20;65(12):1161-1169. Epub 2018 Sep 20.

Department of Diabetes and Endocrinology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.

Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0052DOI Listing
December 2018
13 Reads

Adenocarcinoma of Lung and Bronchial Carcinoid Presenting as Double Synchronous Primary Lung Cancer: A Case Report and Review of Literature.

World J Oncol 2018 Aug 6;9(4):110-114. Epub 2018 Sep 6.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Bronx Care Health System, Bronx, NY 10457, USA.

Recent advances in imaging techniques led to an increase in the incidence of synchronous and metachronous primary lung cancers due to early detection. Management of these patients is challenging and prognosis depends on the stage of the tumor at initial diagnosis and histological type. A 68-year-old African American male patient with medical history of hypertension and diabetes mellitus presented to our emergency department with right sided chest pain, worsening dyspnea and dry cough of 2-week duration. Read More

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http://dx.doi.org/10.14740/wjon1129wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134993PMC
August 2018
9 Reads

Severe metabolic alkalosis-a diagnostic dilemma.

Respir Med Case Rep 2018 24;25:177-180. Epub 2018 Aug 24.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Southern Illinois University School of Medicine, PO Box 19636, Springfield, IL, 62794, USA.

Background: Cushing's syndrome due to ectopic ACTH secretion has been associated with many cancers; most commonly small cell carcinoma of the lung and bronchial carcinoid tumors. Usually, patients who confer this diagnosis have poor prognosis.

Case Presentation: A 66-year-old female presented with worsening shortness of breath and weakness over three days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183003
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http://dx.doi.org/10.1016/j.rmcr.2018.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122389PMC
August 2018
21 Reads