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Zhonghua Bing Li Xue Za Zhi 2021 Jun;50(6):676-678

Department of Pathology, the First Hospital of Lanzhou University, Lanzhou 730000, China.

Medicina (Kaunas) 2021 May 23;57(6). Epub 2021 May 23.

Thoracic Surgery Unit, Department of Organ Transplantation and Emergency, University Hospital of Bari, 70124 Bari, Italy.

Pulmonary sclerosing pneumocytoma is a rare benign pulmonary tumor of primitive epithelial origin. Because of the unspecific radiological features mimicking malignancies and its histological heterogeneity, the differential diagnosis with adenocarcinoma and carcinoid tumors is still challenging. We report our experience of two cases of sclerosing pneumocytoma, as well as a review of the literature. Read More

J Nucl Med 2021 May 28. Epub 2021 May 28.

Peter MacCallum Cancer Centre, Australia.

To assess the efficacy and safety of Lu-DOTATATE in patients with somatostatin receptor (SSR) positive lung neuroendocrine tumor (NET). This is a retrospective review of the outcome of patients with typical carcinoid (TC) and atypical carcinoid (AC), treated with Lu-DOTATATE at two ENETS Centres of Excellence. Morphological imaging (RECIST 1. Read More

Interact Cardiovasc Thorac Surg 2021 May 17. Epub 2021 May 17.

Thoracic Surgery Division, São Paulo State Cancer Institute, São Paulo, Brazil.

We present a case of a young man with an endobronchial carcinoid in the left main bronchus, which was treated integrating probe-based confocal laser endomicroscopy and fluorescence imaging during a robot-assisted bronchoplasty. This technique allowed precise detection of the neoplastic area, avoiding associated lung resection. The incorporation of new technologies to our current practice may lead to a better approach to airway tumours. Read More

Curr Probl Diagn Radiol 2021 Apr 18. Epub 2021 Apr 18.

Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.

Background: Tracheobronchial (TB) tumors follow same pathological classification as lung neoplasms; however, some entities are known to favor airways. Distinction of pathological types is necessary for suggesting appropriate management strategy.

Purpose: To evaluate utility of multidetector CT (MDCT) in differentiation of primary TB tumors; and assess validity of a scoring system based on imaging biomarkers to differentiate tumor types. Read More

Thorac Cancer 2021 Jun 7;12(12):1923-1926. Epub 2021 May 7.

Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

A 79-year-old woman was referred to our facility because of an abnormal chest shadow. Chest computed tomography (CT) showed a solitary right middle lung nodule with a maximum diameter of 3 mm and anterior mediastinal nodule with a maximum diameter of 21 mm. The lung nodule was suspected of being a primary lung cancer rather than a metastatic tumor because there were no primary malignant tumors, apart from an anterior mediastinal tumor visible on diagnostic imaging, including F fluorodeoxyglucose-positron emission tomography, and a solitary lung nodule. Read More

Lung Cancer 2021 06 30;156:117-121. Epub 2021 Apr 30.

Department of Thoracic Surgery, Hôpital Cochin, APHP.CUP, Université de Paris, France. Electronic address:

Introduction: Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) is a rare disease often associated with carcinoid tumors. We aimed at evaluating the impact of DIPNECH on characteristics and prognosis of patients who underwent radical treatment of pulmonary carcinoid tumors.

Material And Methods: We reviewed all patients operated on for curative-intent resection of carcinoid tumor in our department from 2001 to 2020. Read More

Lung Cancer 2021 06 26;156:109-116. Epub 2021 Apr 26.

Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen, Denmark; ENETS Neuroendocrine Tumor Centre of Excellence Rigshospitalet, University of Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Objective: The aim of this study was to determine overall survival and recurrence-free survival after resection of bronchopulmonary carcinoids by means of predominantly minimally invasive surgery and lung-sparing resections. In addition, we aimed to identify prognostic factors for overall survival.

Materials And Methods: Retrospective review of consecutive patients operated for bronchopulmonary carcinoids between January 2009 and October 2020 identified from a prospectively collected database. Read More

Curr Med Imaging 2021 Apr 19. Epub 2021 Apr 19.

Hacettepe University, School of Medicine, Department of Radiology Ankara, Turkey.

Background: Although imaging findings along with patients' clinical history may give clue for the etiology of a pulmonary lesion, the differentiation of benign pulmonary lesions from lung cancer could be challenging.

Objective: The aim of this review article was to increase the awareness of the carcinoma mimicking lung lesions.

Methods: This paper was designed to illustrate rare pulmonary tumors and carcinoma mimickers with emphasis on radiologic-pathologic correlation. Read More

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Radiology, Flinders Medical Centre, Bedford Park, South Australia, Australia.

Pulmonary carcinoid tumours are a rare form of malignancy that often present with clinical heterogeneity and are challenging to diagnose. Diagnosis during pregnancy is further complicated by delays in imaging and procedures to minimise harm to the fetus. This case describes a primigravid healthcare worker who was diagnosed with pulmonary carcinoid in her first trimester of pregnancy, with particular focus on the unique radiological findings of subpleural blebs as a feature. Read More

Asian Cardiovasc Thorac Ann 2021 Apr 14:2184923211010090. Epub 2021 Apr 14.

Department of Cardiothoracic Surgery, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.

Background: Pulmonary carcinoids are rare neoplasms, accounting for approximately 1%-2% of all lung malignancies. A retrospective analysis was undertaken of all patients who underwent surgical resection of pulmonary carcinoid tumours across multiple institutions in Melbourne, Australia.

Methods: From May 2000 through April 2020, 241 patients who underwent surgical resection of pulmonary carcinoid tumours were retrospectively reviewed. Read More

World J Nucl Med 2021 Jan-Mar;20(1):99-101. Epub 2020 Jul 22.

Department of Radiology, Mater Misericordiae University Hospital, Dublin, Ireland.

A 75-year-old male presented with right eye pain and proptosis. His history was significant for renal cell carcinoma treated with left nephrectomy 2 years previously. Computed tomography (CT) imaging demonstrated a 1. Read More

Kyobu Geka 2021 Mar;74(3):197-201

Department of Surgery, Okinawa National Hospital, Ginowan, Japan.

The patient was a woman in her 70's was referred to our hospital because of an abnormal shadow on chest roentgenogram at an annual medical checkup. Since preoperative examinations suggested lung cancer in the right middle lobe, thoracoscopic right middle lobectomy was planned. However, pleural dissemination was detected at surgery and we changed the treatment plan to the intrapleural hyperthermic chemotherapy. Read More

Clin Imaging 2021 Feb 27;77:175-179. Epub 2021 Feb 27.

Division of Cardiothoracic Imaging, Department of Radiology, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, United States of America.

Pulmonary sclerosing pneumocytoma (PSP) is a benign tumor originating from primitive respiratory epithelium which tends to present as an asymptomatic solitary lesion in the periphery of the lung. It primarily occurs in women, with a 5:1 ratio of female to male, and in East Asian populations. We describe a rare case of a gallium-68 (Ga)-DOTATATE avid PSP in a middle-aged man of North African ancestry. Read More

Int J Surg Case Rep 2021 Mar 24;80:105703. Epub 2021 Feb 24.

Department of Surgery, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. Electronic address:

Introduction: Bronchial carcinoid tumors are rare, slow growing, malignant neuroendocrine tumors which arise from Enterochromaffin (Kulchitsky) cells. Early diagnosis is extremely important as the main stay of treatment is surgical excision.

Presentation Of Case: We present a rare case of bronchial typical carcinoid tumor in a 27-year-old male who presented with a complaint of intermittent dry cough of 2 weeks' duration associated with shortness of breath and low grade fever. Read More

Nucl Med Mol Imaging 2021 Feb 7;55(1):31-37. Epub 2021 Jan 7.

Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, University of Southern California, 2250 Alcazar St., CSC 102, Los Angeles, CA 90033 USA.

Purpose: The goal of our retrospective single tertiary academic medical center investigation was to examine the added diagnostic value and clinical impact of Ga-DOTATATE PET/CT in the therapeutic management of patients with neuroendocrine tumors (NETs).

Methods: Imaging database was queried for all "PET-DOTATATE" examinations performed at our tertiary care academic institution using MONTAGE™. The patient's clinical history and recent prior imaging were reviewed. Read More

Lung Cancer 2021 04 23;154:186-194. Epub 2021 Jan 23.

Stanford University School of Medicine, Stanford Cancer Institute, Department of Medicine, Division of Oncology, 875 Blake Wilbur, Stanford, CA, 94305, USA. Electronic address:

Background: Well-differentiated lung neuroendocrine tumors (NETs), also known as typical and atypical carcinoids, have a decreased incidence of lymph node (LN) and distant metastases compared to poorly differentiated lung NETs. We aimed to (i) examine the clinicopathologic features associated with LN involvement in lung carcinoids and (ii) describe the postoperative management of patients with LN metastases.

Methods: We identified 98 patients who underwent surgical resection and lymph node sampling at Stanford University. Read More

Clin Nucl Med 2021 Mar;46(3):e154-e155

From the Department of Nuclear Medicine, Ankara University Medical School, Ankara.

Abstract: We represent the case of a 61-year-old man with atypical carcinoid tumor of the lung. On posttherapy 177Lu-DOTATATE whole-body scan, focal intense uptake in the inferomedial side of the liver was detected. Pretherapy 68Ga-DOTATATE PET/CT showed no sign of liver metastasis, and posttherapy diagnostic dynamic liver MRI is used to exclude metastatic liver disease. Read More

J Indian Assoc Pediatr Surg 2020 Nov-Dec;25(6):363-367. Epub 2020 Oct 27.

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.

Objectives: The objective of the study was to review the imaging features of proven pediatric primary lung tumors, with a purpose of detecting key distinguishing features among the various entities.

Materials And Methods: We retrospectively reviewed multidetector computed tomography (CT) images of 17 pediatric patients with primary lung tumors. For each examination, various CT image descriptors were used to characterize the pulmonary nodules/masses; including location, size, number, morphology, cavitation, calcification, intense enhancement, airway involvement, chest wall/pleural involvement, mediastinal/vascular involvement, and nodal enlargement. Read More

BMC Endocr Disord 2021 Jan 7;21(1). Epub 2021 Jan 7.

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, Yamen Street, Velenjak, Tehran, Iran.

Background: Neuroendocrine tumor (NET) with adrenocorticotropic hormone (ACTH) secretion are very rare. To our knowledge, no follow-up study is published for ACTH-secreting NET, regardless of the primary site, to show second occurrence of tumor after a long follow-up, following resection of primary tumor.

Case Presentation: Here, we describe a 49-year-old-man with cushingoid feature, drowsiness and quadriparesis came to emergency department at December 2005. Read More

Cancers (Basel) 2020 Dec 22;13(1). Epub 2020 Dec 22.

Molecular Oncology Unit (CIEMAT), Institute of Biomedical Research, University Hospital "12 de Octubre", CIBERONC, 28040 Madrid, Spain.

Neuroendocrine lung tumors comprise a range of malignancies that extend from benign tumorlets to the most prevalent and aggressive Small Cell Lung Carcinoma (SCLC). They also include low-grade Typical Carcinoids (TC), intermediate-grade Atypical Carcinoids (AC) and high-grade Large Cell Neuroendocrine Carcinoma (LCNEC). Optimal treatment options have not been adequately established: surgical resection when possible is the choice for AC and TC, and for SCLC chemotherapy and very recently, immune checkpoint inhibitors. Read More

BMJ Case Rep 2020 Dec 21;13(12). Epub 2020 Dec 21.

Surgery, Centro Hospitalar Lisboa Norte EPE, Lisboa, Portugal.

Type 1 multiple endocrine neoplasia (MEN-1) syndrome is an autosomal dominant disease, associated with germline mutations in the MEN-1 tumour suppressor gene (encoding the menin protein). Recent studies, through a better characterisation of the functions of the menin protein, have started to demonstrate how changes in this protein may be related to breast cancer. We present the case of a patient whose diagnosis of MEN-1 syndrome was made during treatment for a breast tumour-this diagnosis was obtained after finding multiple neoplastic lesions that fitted the MEN-1 syndrome spectrum, during the initial staging and subsequent follow-up of a breast tumour. Read More

Eur J Cancer 2021 02 25;144:200-214. Epub 2020 Dec 25.

Department of Medical Oncology and Hematology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada. Electronic address:

Neuroendocrine neoplasms (NENs) are a heterogeneous family of uncommon tumours with challenging diagnosis, clinical management and unique needs that almost always requires a multidisciplinary approach. In the absence of guidance from the scientific literature, along with the rapidly changing data available on the effect of COVID-19, we report how 12 high-volume NEN centres of expertise in 10 countries at different stages of the evolving COVID-19 global pandemic along with members of international neuroendocrine cancer patient societies have suggested to preserve high standards of care for patients with NENs. We review the multidisciplinary management of neuroendocrine neoplasms during the COVID-19 pandemic, and we suggest potential strategies to reduce risk and aid multidisciplinary treatment decision-making. Read More

Lung Cancer Manag 2020 Sep 14;9(4):LMT41. Epub 2020 Sep 14.

Thoracic Surgery Division, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Ectopic adrenocorticotropic hormone (ACTH) syndrome is rare and identification of its source is often challenging. We report the case of an ectopic Cushing syndrome in a young adult male secondary to an occult ACTH producing atypical carcinoid tumor. Extensive biochemical and imaging workup was unrevealing. Read More

Thorac Cancer 2021 02 9;12(3):397-401. Epub 2020 Dec 9.

Department of Respiratory Medicine, Kumamoto University Hospital, Kumamoto, Japan.

A pulmonary carcinoid tumor is a rare tumor that lacks a validated therapeutic approach for unresectable disease. Understanding the intersite tumor-immune heterogeneity is essential to harness the immune system for cancer therapy. However, little is known about the tumor-immune microenvironment (TIME). Read More

J Thorac Dis 2020 Nov;12(11):6978-6991

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Ongoing technologic and therapeutic advancements in medicine are now testing the limits of conventional anatomic imaging techniques. The ability to image physiology, rather than simply anatomy, is critical in the management of multiple disease processes, especially in oncology. Nuclear medicine has assumed a leading role in detecting, diagnosing, staging and assessing treatment response of various pathologic entities, and appears well positioned to do so into the future. Read More

J Int Med Res 2020 Nov;48(11):300060520962928

Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

When a patient harbors two or more neuroendocrine tumors (NETs), it can be difficult to determine whether they are double primary tumors or metastases. A 60-year-old man complained of voice change lasting 1 month. On physical examination and imaging, a 1. Read More

Int J Clin Exp Pathol 2020 1;13(10):2599-2607. Epub 2020 Oct 1.

Department of Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University No. 20 East Yuhuangding Road, Yantai, Shandong, China.

Sclerosing pneumocytoma (SP) is a rare and benign tumor predominantly occurring in Asian women, easily misdiagnosed by imaging and pathologic frozen diagnosis during surgery because of its diverse histomorphology (4 structures, 2 types of cells). It may form multiple tumors. When SP is combined with carcinoid, adenoma, or other tumors (although rare), diagnosis is more complicated. Read More

J Thorac Dis 2020 Sep;12(9):5140-5146

Department of Diagnostic and Interventional Radiology, City of Hope National Medical Center, Duarte, CA, USA.

Theranostics is a re-emerging field of medicine that aims to create targeted agents that can be used for diagnostic and/or therapeutic indications. In the past, theranostics has been used to treat neoplasms, such as thyroid cancer and neuroblastomas. More recently, theranostics has seen a resurgence with advent of new therapeutic antibodies and small molecules which can be transformed into Theranostic agents through radioconjugating with a radioactive isotope. Read More

J Thorac Dis 2020 Sep;12(9):4817-4824

First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Background: Pulmonary segmentectomy is an important surgical option for complete resection in patients with poor lung function. However, correctly recognizing the intersegmental plane for accurate segmentectomy is sometimes difficult. We therefore developed a novel method that allows the detection of intersegmental planes using an indocyanine green (ICG) fluorescence imaging device, photodynamic eye (PDE) camera, PDE-neo. Read More