694 results match your criteria Lung Carcinoid Imaging


Spontaneous Partial Regression of a Carcinoid Tumor: Radiology May Not Capture the Real Picture.

Turk Thorac J 2019 Jan 31;20(2):153-156. Epub 2019 Jan 31.

Department of Pulmonary Medicine, Pacific Medical College and Hospital, Udaipur, Rajasthan, India.

A partial or complete resolution of the neoplastic lesion, either spontaneously or in the presence of therapy that is considered inadequate to exert significant influence on the growth of the neoplastic lesion, is considered a spontaneous regression. This phenomenon is extremely rare in lung neoplasms. A close follow up with imaging along with bronchoscopy and a biopsy of the lesion is essential, as they may have potential for distant spread even during radiological regression. Read More

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http://dx.doi.org/10.5152/TurkThoracJ.2018.18059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453627PMC
January 2019
1 Read

A case of pseudocystic liver metastases from an atypical lung carcinoid tumor.

Radiol Case Rep 2019 May 6;14(5):595-601. Epub 2019 Mar 6.

Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.

Metastatic neuroendocrine tumors of the liver typically appear as solid, hypervascular masses on imaging. Pseudocysts mimicking simple cysts are extremely rare. A 42-year-old Japanese woman was referred with a single pulmonary mass in the left lower lobe. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406078PMC
May 2019
1 Read

The utility of 18F-FDG and 68Ga-DOTA-Peptide PET/CT in the evaluation of primary pulmonary carcinoid: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Mar;98(10):e14769

Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

Background: Pulmonary carcinoids (PC) are histologically classified into typical carcinoid (TC) and atypical carcinoid (AC). The diagnosis of pulmonary carcinoid and possibly the differentiation between TC and AC could make a significant effect on the treatment planning as well as prognosis. Several studies have explored the utility of Ga-DOTA-Peptide (Ga-labelled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-peptide) and F-flurodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in the evaluation of primary pulmonary carcinoids. Read More

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http://dx.doi.org/10.1097/MD.0000000000014769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417554PMC
March 2019
4 Reads

Postpneumonectomy-like syndrome due to bronchial carcinoid: a unique case report.

BMC Pulm Med 2019 Feb 18;19(1):44. Epub 2019 Feb 18.

1st Respiratory Medicine Department, University of Athens, "Sotiria" Hospital, 152 Mesogeion Ave, 115 27, Athens, Greece.

Background: Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contralateral hemithorax, mimicking the mediastinal shift observed in postpneumonectomy syndrome after pneumonectomy. We report a unique case of postpneumonectomy-like syndrome caused by an atypical bronchial carcinoid completely occluding the left main bronchus.

Case Presentation: A 25-year-old woman presented with symptoms of chronic exertional dyspnea and productive cough. Read More

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http://dx.doi.org/10.1186/s12890-018-0767-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380005PMC
February 2019
1 Read

Somatostatin Receptor Expression Is Associated With Metastasis and Patient Outcome in Pulmonary Carcinoid Tumors.

J Clin Endocrinol Metab 2019 Jun;104(6):2083-2093

Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Context: Pulmonary carcinoids (PCs) belong to neuroendocrine tumors that often overexpress somatostatin receptors (SSTRs). This overexpression provides a molecular basis for tumor imaging and treatment with somatostatin analogs.

Objective: To evaluate SSTR1 to SSTR5 distribution in a large set of PC tumors and to investigate whether the expression is associated with clinicopathological and outcome data. Read More

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http://dx.doi.org/10.1210/jc.2018-01931DOI Listing
June 2019
14 Reads

NETest Liquid Biopsy Is Diagnostic of Lung Neuroendocrine Tumors and Identifies Progressive Disease.

Neuroendocrinology 2019 Jan 17. Epub 2019 Jan 17.

University of Warmia and Mazury, Olsztyn, Poland.

Background: There are no effective biomarkers for the management of bronchopulmonary carcinoids (BPC). We examined the utility of a neuroendocrine multigene transcript "liquid biopsy" (NETest) in BPC for diagnosis and monitoring of the disease status.

Aim: To independently validate the utility of the NETest in diagnosis and management of BPC in a multicenter, multinational, blinded study. Read More

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http://dx.doi.org/10.1159/000497037DOI Listing
January 2019
19 Reads

18F-FDG PET/CT and nestin expression as prognostic tools in pulmonary neuroendocrine tumours.

Nucl Med Commun 2019 Apr;40(4):353-360

Departments of Endocrinology, Metabolism and Internal Medicine.

Objectives: The aim of this study was to investigate the fluorine-18-fluorodeoxyglucose (F-FDG) uptake on integrated PET [PET/computed tomography (CT)] images and its correlation with nestin expression in a series of neuroendocrine lung tumours. As the incidence of neuroendocrine lung tumours is rising, tools predicting diagnosis, outcome and assisting in the selection of treatment regimens are needed.

Patients And Methods: We reviewed records of patients diagnosed with large cell neuroendocrine lung carcinoma, atypical carcinoid and typical carcinoid who were operated upon in our institution. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000972DOI Listing

Case of Solitary Peritoneal Metastasis From Atypical Bronchopulmonary Carcinoid on 18F-FDG PET/CT.

Clin Nucl Med 2019 Mar;44(3):e154-e157

Department of Histopathology, HCG Cancer Centre, Bangalore, India.

Atypical lung carcinoids frequently metastasize to mediastinal nodes, liver, bone, lungs, and brain and rarely to ovaries, pancreas, subcutaneous, and skin. Solitary peritoneal metastasis is extremely rare and unreported previously. We present a case of a 36-year-old woman with cough, hemoptysis, dyspnea with detection of lung mass, and incidental detection of pelvic mass. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002441DOI Listing
March 2019
5 Reads

Cyclic Cushing's syndrome caused by neuroendocrine tumor: a case report.

Endocr J 2019 Feb 19;66(2):175-180. Epub 2018 Dec 19.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

Cushing's syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing's syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing's syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0168DOI Listing
February 2019
21 Reads

Metastatic thymic carcinoid responds to chemoradiation and octreotide: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13286

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Rationale: Thymic carcinoids are a rare type of malignant neuroendocrine tumors which have a poor prognosis due to their distant metastasis, invasive behaviour, and postoperative recurrence. Surgical resection is still the fundamental mode for treating thymic carcinoids. Here, we report the rapid shrinkage of an atypical thymic carcinoid with multiple metastases following chemoradiation plus octreotide as a first-line therapy PATIENT CONCERNS:: A 39-year-old Chinese man presented with chest tightness, dyspnea with a history of lumbago and untreated malignant thymoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393003PMC
November 2018
19 Reads

Primary Lung Tumors in Children: Radiologic-Pathologic Correlation From the Radiologic Pathology Archives.

Radiographics 2018 Nov-Dec;38(7):2151-2172

From the Department of Radiology and Radiological Sciences (J.P.L., E.M.C.) and Department of Pathology (J.P.L., A.R.H., E.M.C.), Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814; Thoracic Radiology Section (J.P.L., D.M.B.) and Pediatric Radiology Section (D.M.B., E.M.C.), American Institute for Radiologic Pathology, Silver Spring, Md; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pa (D.M.B.); Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Tex (B.W.C.); and Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (M.A.P.).

Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Read More

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http://dx.doi.org/10.1148/rg.2018180192DOI Listing
November 2018
2 Reads

68Ga-DOTATOC PET/CT in Thyroid Metastases of Lung Carcinoid.

Clin Nucl Med 2018 Dec;43(12):e492-e494

Dipartimento di Medicina Sperimentale, Università di Roma "Sapienza".

We report the case of a 43-year-old man with a history of lung carcinoid and a recent detection of thyroid nodules by ultrasound. The cytological analysis raised the suspicion of medullary thyroid carcinoma; however, calcitonin and carcinoembryonic antigen levels were in reference range. Considering the previous diagnosis of lung carcinoid, the patient underwent whole-body Ga-DOTATOC PET/CT. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002331DOI Listing
December 2018
3 Reads

A case of ectopic ACTH syndrome due to DDAVP-sensitive but V1b receptor-negative bronchial typical carcinoid with lymphatic metastasis and plasma ProGRP elevation.

Endocr J 2018 Dec 20;65(12):1161-1169. Epub 2018 Sep 20.

Department of Diabetes and Endocrinology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.

Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0052DOI Listing
December 2018
5 Reads

Adenocarcinoma of Lung and Bronchial Carcinoid Presenting as Double Synchronous Primary Lung Cancer: A Case Report and Review of Literature.

World J Oncol 2018 Aug 6;9(4):110-114. Epub 2018 Sep 6.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Bronx Care Health System, Bronx, NY 10457, USA.

Recent advances in imaging techniques led to an increase in the incidence of synchronous and metachronous primary lung cancers due to early detection. Management of these patients is challenging and prognosis depends on the stage of the tumor at initial diagnosis and histological type. A 68-year-old African American male patient with medical history of hypertension and diabetes mellitus presented to our emergency department with right sided chest pain, worsening dyspnea and dry cough of 2-week duration. Read More

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http://dx.doi.org/10.14740/wjon1129wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134993PMC
August 2018
5 Reads

Severe metabolic alkalosis-a diagnostic dilemma.

Respir Med Case Rep 2018 24;25:177-180. Epub 2018 Aug 24.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Southern Illinois University School of Medicine, PO Box 19636, Springfield, IL, 62794, USA.

Background: Cushing's syndrome due to ectopic ACTH secretion has been associated with many cancers; most commonly small cell carcinoma of the lung and bronchial carcinoid tumors. Usually, patients who confer this diagnosis have poor prognosis.

Case Presentation: A 66-year-old female presented with worsening shortness of breath and weakness over three days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183003
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http://dx.doi.org/10.1016/j.rmcr.2018.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122389PMC
August 2018
12 Reads

[Typical Carcinoid of the Lung with Abnormal Elevation of Serum Pro-gastrin-releasing Peptide (ProGRP)].

Kyobu Geka 2018 Aug;71(8):593-596

Department of Thoracic Surgery, National Defense Medical Callege, Tokorozawa, Japan.

A 40-year-old male was referred to our hospital because of a nodular shadow detected in the left lower lobe with the tendency to increase gently. Because fluoro-2-deoxy-D-glucose (FDG) uptake was extremely low on a FDG positron emission tomography (PET-CT), the tumor was highly suspected of the benign tumor. Five years later, a follow-up computed tomography (CT) showed the shadow to be enlarged. Read More

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August 2018
10 Reads

Quadruple Valve Replacement for Carcinoid Heart Disease.

Braz J Cardiovasc Surg 2018 Jul-Aug;33(4):398-403

Freeman Hospital Newcastle, United Kingdom of Great Britain and Northern Ireland.

Introduction: Carcinoid heart disease most frequently involves the tricuspid or, more rarely, the pulmonary valve and presents with right heart failure as 5-HT is metabolized by the lung. Left-sided valve involvement is quite rare. We describe our experience of 3 patients presenting with heart failure secondary to carcinoid heart disease affecting all four cardiac valves. Read More

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http://dx.doi.org/10.21470/1678-9741-2017-0224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122765PMC
January 2019
4 Reads

A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors.

J Thorac Dis 2018 Jul;10(7):3928-3939

Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, Milan, Italy.

Background: Broncho-pulmonary neuroendocrine tumors (bpNETs) are rare malignancies and there is no consensus on therapeutical management of metastatic disease and follow-up after radical resection.

Methods: Clinical records of patients with a cytological or histological diagnosis of bpNETs and distant metastases (metachronous or synchronous), evaluated at the European Institute of Oncology between 1997 and 2014, were retrospectively analyzed. Data on patient demographics, pathology, imaging exams, surgical and non-surgical treatments were collected. Read More

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http://dx.doi.org/10.21037/jtd.2018.06.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106014PMC
July 2018
14 Reads

Assessment of NETest Clinical Utility in a U.S. Registry-Based Study.

Oncologist 2018 Aug 29. Epub 2018 Aug 29.

Memorial Sloan Kettering Cancer Center, New York, New York, USA

Background: The clinical relevance of molecular biomarkers in oncology management has been recognized in breast and lung cancers. We evaluated a blood-based multigene assay for management of neuroendocrine tumors (NETs) in a real-world study (U.S. Read More

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http://dx.doi.org/10.1634/theoncologist.2017-0623DOI Listing
August 2018
35 Reads

Noninvasive pulmonary nodule characterization using transcutaneous bioconductance: Preliminary results of an observational study.

Medicine (Baltimore) 2018 Aug;97(34):e11924

Division of Radiology.

We sought to assess the use of an electro pulmonary nodule (EPN) scanner (FreshMedx, Salt Lake City, UT) in the noninvasive characterization of pulmonary nodules using transcutaneous bioconductance.Monocentric prospective study including patients with a pulmonary nodule identified on a chest computed tomography scan. Study protocol approved by the institutional review board and written consent was obtained for every patient. Read More

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http://Insights.ovid.com/crossref?an=00005792-201808240-0005
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http://dx.doi.org/10.1097/MD.0000000000011924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113006PMC
August 2018
9 Reads

[Atypical Pulmonary Carcinoid Tumor with Elevated Serum ProGRP;Report of a Case].

Kyobu Geka 2018 Mar;71(3):236-239

Department of Thoracic Surgery, Mie Chuo Medical Center, Tsu, Japan.

We report a case of an atypical pulmonary carcinoid with high serum ProGRP. A 78-year-old man was found to have an abnormal shadow by a chest X-ray. Chest computed tomography (CT) revealed a solitary pulmonary nodule in the right middle lobe, which was homogeneous, well demarcated, and round. Read More

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March 2018
2 Reads

The Ectopic Adrenocorticotropic Hormone Syndrome: Rarely Easy, Always Challenging.

Endocrinol Metab Clin North Am 2018 06;47(2):409-425

Neuroendocrine Tumour Unit, Royal Free Hospital, Pond Street, London NW3 2QG, UK. Electronic address:

Despite modern imaging techniques, differentiating ectopic adrenocorticotropic hormone (ACTH) syndrome from pituitary-dependent Cushing's syndrome, Cushing's disease, is especially difficult when well-differentiated carcinoids are the source of ACTH secretion, particularly pulmonary carcinoid tumors. ACTH-secreting pulmonary carcinoids, like the corticotroph adenomas causing Cushing's disease, are often small and difficult to detect, and patients present with a gradual onset of the classical signs and symptoms of Cushing's syndrome, indistinguishable from the presentation of Cushing's disease. Hence, the differential diagnosis relies on a combination of clinical assessment, dynamic biochemical tests, inferior petrosal sinus sampling, and multimodal imaging, each with its own caveats and pitfalls. Read More

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http://dx.doi.org/10.1016/j.ecl.2018.01.005DOI Listing
June 2018
9 Reads

Endobronchial carcinoid tumor: Radiological findings of a clinical case.

Rev Assoc Med Bras (1992) 2018 Jan;64(1):15-18

Department of Radiology and Medical Imaging, Documenta - Hospital São Francisco, Ribeirão Preto, SP, Brazil.

We describe the case of a female patient, 21 years old, complaining of dyspnea attacks and wheezing 2 years ago. Chest radiography showed volume loss in the left lower lobe and ipsilateral retrocardiac triangular basal opacity. CT scan showed an extensive solid mass with apex protruding into the left main and lower lobar bronchi, causing distal atelectasis. Read More

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http://dx.doi.org/10.1590/1806-9282.64.01.15DOI Listing
January 2018
9 Reads

PRRT genomic signature in blood for prediction of Lu-octreotate efficacy.

Eur J Nucl Med Mol Imaging 2018 07 26;45(7):1155-1169. Epub 2018 Feb 26.

LuGenIum Consortium, Milan, Rotterdam, London, Bad Berka, 54 Portland Place, London, W1B1DY, UK.

Background: Peptide receptor radionuclide therapy (PRRT) utilizes somatostatin receptor (SSR) overexpression on neuroendocrine tumors (NET) to deliver targeted radiotherapy. Intensity of uptake at imaging is considered related to efficacy but has low sensitivity. A pretreatment strategy to determine individual PRRT response remains a key unmet need. Read More

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http://link.springer.com/10.1007/s00259-018-3967-6
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http://dx.doi.org/10.1007/s00259-018-3967-6DOI Listing
July 2018
13 Reads

Endobronchial Tuberculosis Simulating Carcinoid Tumor.

J Coll Physicians Surg Pak 2018 Mar;28(3):S39-S41

Medical Student, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Diagnosing endobronchial tuberculosis (EBTB) can be difficult due to the lack of specific signs and symptoms that differentiate it from other respiratory diseases, such as lung tumors. We hereby report a case of a very rare presentation of tuberculosis (TB) in a patient who presented with a dry cough and significant weight loss for 3 months. Chest X-ray and CT scan of the chest showed partial atelectasis and a segmental collapse of the right upper lobe and tumor-like arising from its bronchus along with a large right para-tracheal mediastinal lymphadenopathy, mimicking a metastatic (N2) disease. Read More

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http://dx.doi.org/10.29271/jcpsp.2018.03.S39DOI Listing
March 2018
10 Reads
0.320 Impact Factor

Subcutaneous metastasis of a pulmonary carcinoid tumor: A case report.

Medicine (Baltimore) 2018 Jan;97(2):e9415

Department of Pulmonology.

Rationale: Carcinoid tumors are derived from neuroendocrine cells and are most frequently found in the gastrointestinal tract and bronchopulmonary system. They are generally characterized by an indolent clinical course but may in some instances spread to regional lymph nodes or to distant sites. Subcutaneous metastases of carcinoid tumors are extremely rare; there are only few cases reported in the literature and the site of the primary tumor was mainly the gastrointestinal tract. Read More

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http://dx.doi.org/10.1097/MD.0000000000009415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943869PMC
January 2018
10 Reads

An assessment of F-FDG PET/CT for thoracic screening and risk stratification of pulmonary nodules in multiple endocrine neoplasia type 1.

Clin Endocrinol (Oxf) 2018 May 6;88(5):683-691. Epub 2018 Mar 6.

Department of Diabetes & Endocrinology, Royal Hobart Hospital, Hobart, TAS, Australia.

Context: Bronchopulmonary neuroendocrine tumours (bpNETs) and thymic carcinoid (ThC) are features of multiple endocrine neoplasia type 1 (MEN 1), and surveillance guidelines recommend periodic thoracic imaging. The optimal thoracic imaging modality and screening frequency remain uncertain as does the prognosis of small lung nodules when identified.

Objectives: To evaluate fluorodeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT) for identification and prognostic assessment of thoracic lesions in MEN 1. Read More

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http://dx.doi.org/10.1111/cen.13573DOI Listing
May 2018
11 Reads

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) Syndrome and Carcinoid Tumors With/Without NECH: A Clinicopathologic, Radiologic, and Immunomolecular Comparison Study.

Am J Surg Pathol 2018 05;42(5):646-655

Laboratory of Medicine, Pathology Unit, Mayo Clinic, Scottsdale, AZ.

The diagnostic criteria of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) are not well defined, and DIPNECH can be mistaken for carcinoids associated with neuroendocrine cell hyperplasia (NECH). In this study, we compared clinical, radiologic, histologic, immunohistochemical, and molecular features of DIPNECH and isolated carcinoids with/without NECH. The study population included 151 cases (77 female patients and 74 male patients), 19 with DIPNECH and 132 with carcinoids with/without NECH. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001033DOI Listing
May 2018
14 Reads
5.145 Impact Factor

Radiological features and metastatic patterns of thymic neuroendocrine tumours.

Clin Radiol 2018 05 6;73(5):479-484. Epub 2018 Jan 6.

Department of Radiology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

Aim: To investigate the clinical and image features of thymic neuroendocrine tumours (NETs), and characterise the radiological patterns of recurrence and metastasis on serial imaging studies.

Materials And Methods: The study included 14 patients (11 males) with a histopathological diagnosis of thymic NETs (one typical carcinoid, eight atypical carcinoid, and five large cell neuroendocrine carcinoma). Preoperative images were assessed for features of primary tumours. Read More

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http://dx.doi.org/10.1016/j.crad.2017.11.025DOI Listing
May 2018
8 Reads

Marked 18-Fuorine-Fluorodeoxyglucose (FDG) Avidity of an Intrapulmonary Typical Carcinoid Tumor Manifesting as a Bronchocele in an Asymptomatic Middle-Aged Woman.

Am J Case Rep 2017 Dec 28;18:1390-1395. Epub 2017 Dec 28.

Diagnostic Radiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.

BACKGROUND Intrapulmonary carcinoid tumors (ICTs) are malignant, slow-growing tumors classified as either: i) typical, less aggressive, well-differentiated tumors or ii) atypical, more aggressive, poorly-differentiated tumors. Most typical carcinoid tumors originate in the central airway and present with symptoms related to bronchial obstruction. In contrast, atypical carcinoids tend to occur more peripherally and are generally detected incidentally as a solitary pulmonary nodule (SPN). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753618PMC
December 2017
3 Reads

The Clinicopathological Aspects of Primary Presacral Neuroendocrine Neoplasms: One Center Experience.

Pancreas 2018 01;47(1):122-129

Objectives: Presacral neuroendocrine neoplasms (NENs) are rare entities that are found at the presacral space. We report our experience in the diagnosis, management, and outcomes of primary presacral NENs.

Methods: This was an institutional review board-approved retrospective review of medical records and surgical pathology specimens of patients with a diagnosis of NENs at Cedars-Sinai Medical Center between January 2000 and April 2016. Read More

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http://dx.doi.org/10.1097/MPA.0000000000000954DOI Listing
January 2018
8 Reads

[Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (dipnech) - an overview of the cases diagnosed at the department of thoracic surgery in the years 2010-2014].

Wiad Lek 2017;70(5):1005-1012

Oddział Chorob Wewnętrznych, Centrum Pulmonologii I Torakochirurgii, Bystra, Polska.

Introduction: Pulmonary neuroendocrine cells (PNEC) are present in the normal lungs with the incidence of 1 in 2500 epithelial cells. They usually proliferate in the presence of reactive processes related to inflammation and fibrosis of the lung parenchyma. The division of pulmonary neuroendocrine cell hyperplasia proposed by Travis et al. Read More

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March 2018
3 Reads

Atypical lung carcinoid: An unusual presentation.

Indian J Cancer 2017 Jan-Mar;54(1):213-214

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

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http://dx.doi.org/10.4103/ijc.IJC_150_17DOI Listing
October 2018
2 Reads

Non-Small-Cell Lung Cancer PET Imaging Beyond F18 Fluorodeoxyglucose.

Authors:
Gang Cheng

PET Clin 2018 Jan 23;13(1):73-81. Epub 2017 Oct 23.

Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

F18 Flurodeoxyglucose (FDG) is a nonspecific PET tracer representing tumor energy metabolism, with common false-positive and false-negative findings in clinical practice. Non-small cell lung cancer is highly heterogeneous histologically, biologically, and molecularly. Novel PET tracers designed to characterize a specific aspect of tumor biology or a pathway-specific molecular target have the potential to provide noninvasive key information in tumor heterogeneity for patient stratification and in the assessment of treatment response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15568598173010
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http://dx.doi.org/10.1016/j.cpet.2017.09.006DOI Listing
January 2018
19 Reads

Lung Neoplasms with Low F18-Fluorodeoxyglucose Avidity.

Authors:
Yiyan Liu

PET Clin 2018 Jan 20;13(1):11-18. Epub 2017 Oct 20.

Nuclear Medicine Service, Department of Radiology, New Jersey Medical School, Rutgers University, University Hospital, 150 Bergen Street, H141, Newark, NJ 07103, USA. Electronic address:

Some malignant lung neoplasms may demonstrate low or absent uptake on F18-fluorodeoxyglucose (FDG) PET/computed tomography. Pathologic type and clinical stage are independent factors associated with FDG avidity. Among lung malignancies with low FDG avidity, adenocarcinoma in situ and carcinoid are the most common. Read More

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http://dx.doi.org/10.1016/j.cpet.2017.08.002DOI Listing
January 2018
1 Read

The utility of blood neuroendocrine gene transcript measurement in the diagnosis of bronchopulmonary neuroendocrine tumours and as a tool to evaluate surgical resection and disease progression.

Eur J Cardiothorac Surg 2018 03;53(3):631-639

Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

Objectives: The management of bronchopulmonary neuroendocrine tumours (BPNETs) is difficult, since imaging, histology and biomarkers have a limited value in diagnosis, predicting outcome and defining therapeutic efficacy. We evaluated a NET multigene blood test (NETest) to diagnose BPNETs, assess disease status and evaluate surgical resection.

Methods: (i) Diagnostic cohort: BP carcinoids (n = 118)-typical carcinoid, n = 67 and atypical carcinoid, n = 51; other lung NEN (large-cell neuroendocrine carcinoma and small-cell lung carcinoma, n = 13); adenocarcinoma, (n = 26); squamous cell carcinoma (n = 23); controls (n = 90) and chronic obstructive pulmonary disease (n = 18). Read More

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http://dx.doi.org/10.1093/ejcts/ezx386DOI Listing
March 2018
32 Reads

Patient with typical carcinoid initially diagnosed as high-grade neuroendocrine carcinoma.

Lung Cancer Manag 2017 Nov 26;6(2):41-45. Epub 2017 Oct 26.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1192 East Newport Center Drive, Suite 100, Deerfield Beach, FL 33442-7753, USA.

We report the case of a patient initially diagnosed with a high-grade neuroendocrine carcinoma, which 5 years later was determined to have a low-grade typical carcinoid. The patient received radiotherapy and numerous chemotherapy regimens for treatment of a high-grade metastatic mixed large and small cell neuroendocrine carcinoma, without a significant response to any treatment. Subsequent imaging revealed widely metastatic disease and computed tomography-guided biopsy demonstrated a carcinoid tumor with no necrosis. Read More

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http://dx.doi.org/10.2217/lmt-2017-0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310322PMC
November 2017

Coexisting Thymic and Pulmonary Carcinoid Tumors Associated with Multiple Endocrine Neoplasia Type1.

Ann Thorac Cardiovasc Surg 2018 Jun 26;24(3):147-150. Epub 2017 Oct 26.

Department of Pathology, National Hospital Organization Kyoto Medical Center, Kyoto, Kyoto, Japan.

An anterior mediastinal tumor was detected in a 45-year-old female during a medical checkup. Chest computed tomography (CT) showed the anterior mediastinal tumor and a pulmonary tumor in the right lower lobe. Furthermore, tumors of the parathyroid gland, pancreas, and pituitary gland were also detected. Read More

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http://dx.doi.org/10.5761/atcs.cr.17-00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033522PMC
June 2018
6 Reads

Surgical Resection for Pulmonary Carcinoid: Long-Term Results of Multicentric Study-The Importance of Pathological N Status, More Than We Thought.

Lung 2017 12 11;195(6):789-798. Epub 2017 Oct 11.

Department of Thoracic Surgery, Cochin Hospital, AP-HP, Paris, France.

Background: Histological subdivision into typical (TC) and atypical (AC) is crucial for treatment and prognosis of lung carcinoids but can be also very challenging, even for experts. In this study, we aimed to strengthen or reduce the prognostic value of several pathological, clinical, or per-operative factors some of which are still controversial.

Methods: We retrospectively reviewed clinical records related to 195 patients affected by TC (159) or AC (36) surgically treated between 2000 and 2014, in three different centers. Read More

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http://link.springer.com/10.1007/s00408-017-0056-8
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http://dx.doi.org/10.1007/s00408-017-0056-8DOI Listing
December 2017
38 Reads

Resection of the Tracheobronchial Bifurcation With Complete Preservation of Lung Parenchyma.

Ann Thorac Surg 2017 Nov 19;104(5):1741-1747. Epub 2017 Sep 19.

Department of Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Background: The resection of the tracheobronchial bifurcation with complete preservation of lung parenchyma remains a challenge owing to the limited indications for surgery, anesthesiologic management, operative technique, and postoperative course. The aim of this retrospective study was to evaluate factors influencing the perioperative course and long-term survival.

Methods: Between 1989 and 2014, 19 patients underwent a resection of the distal trachea and carina with complete preservation of lung tissue, 16 for malignant tumors (7 adenoid cystic carcinomas, 3 carcinoid tumors, 3 mucoepidermoid tumors, 2 squamous cell carcinomas, and 1 small cell carcinomas), 2 for inflammatory stenosis, and 1 after a complex traumatic rupture. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2017.05.053DOI Listing
November 2017
9 Reads

Two cases of the bronchial carcinoid tumors successfully treated with the parenchymal-sparing bronchoplastic resections.

J Thorac Dis 2017 Aug;9(8):E669-E673

Division of Angiology, Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland.

Carcinoid tumors account for 2% of primary lung tumors. We report two cases of the relatively young patients with typical and atypical carcinoid (AC) tumors that were managed successfully with a parenchymal-sparing bronchoplastic procedure. Read More

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http://dx.doi.org/10.21037/jtd.2017.06.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594198PMC
August 2017
10 Reads

Paraneoplastic Cushing syndrome, case-series and review of the literature.

Acta Clin Belg 2018 Aug 12;73(4):298-304. Epub 2017 Sep 12.

a Departments of Respiratory Medicine and Endocrinology , AZ Sint-Jan Hospital , Bruges , Belgium.

Objectives: Paraneoplastic Cushing syndrome is a rare condition, representing a small fraction of the adrenocorticotropic hormone (ACTH)-dependent cases of Cushing syndrome Methods: Four case descriptions and literature review, highlighting the diagnostic challenges and treatment options are presented.

Results: Different tumor types can be associated with ectopic ACTH secretion. The most common types are bronchial carcinoids and small cell lung carcinoma (SCLC). Read More

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http://dx.doi.org/10.1080/17843286.2017.1373927DOI Listing
August 2018
5 Reads

Endobronchial Carcinoid Tumor Totally Occluding the Left Main Bronchus Without Producing Symptoms of Bronchial Obstruction.

In Vivo 2017 Sep-Oct;31(5):1023-1025

Department of Thoracic Surgery, University College London Hospitals (UCLH), London, U.K.

Background: Bronchial carcinoid tumors (BCTs) are rare neuroendocrine neoplasms of the lung that mainly have a central distribution. They are classified as typical and atypical, with the former variant generally conferring a more favorable survival. Central tumors are usually symptomatic with features of bronchial obstruction, whereas peripheral tumors may remain silent. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656846PMC
May 2018
39 Reads
1.150 Impact Factor

Management of pulmonary neuroendocrine tumors.

Rev Endocr Metab Disord 2017 Dec;18(4):433-442

Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.

Neuroendocrine tumors (NETs) of the lung are divided into 4 major types: small cell lung cancer (SCLC), large cell neuroendocrine carcinoma (LCNEC), atypical carcinoid (AC) or typical carcinoid (TC). Each classification has distinctly different treatment paradigms, making an accurate initial diagnosis essential. The inconsistent clinical presentation of this disease, however, makes this difficult. Read More

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http://dx.doi.org/10.1007/s11154-017-9429-9DOI Listing
December 2017
25 Reads

Histologically Proven Myocardial Carcinoid Metastases: The Value of Multimodality Imaging.

Can J Cardiol 2017 10 16;33(10):1336.e9-1336.e12. Epub 2017 Jun 16.

NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK; Imperial College London, National Heart and Lung Institute, London, UK. Electronic address:

We present a case of a patient with intramyocardial metastases from a carcinoid tumor. These findings were detected using cardiovascular magnetic resonance imaging, with functional metabolic activity analyzed using nuclear imaging and confirmed by histologic findings at surgical biopsy. This case highlights the value of cardiovascular magnetic resonance imaging and the importance of multimodality imaging. Read More

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http://dx.doi.org/10.1016/j.cjca.2017.06.007DOI Listing
October 2017
26 Reads

[CT and MRI findings of primary hepatic neuroendocrine neoplasm].

Zhonghua Zhong Liu Za Zhi 2017 Aug;39(8):600-606

Department of Pathology, Hainan Branch of PLA General Hospital, Sanya 572013, China.

To study imaging features of primary hepatic neuroendocrine neoplasm (PHNEN) with CT and MRI. CT/MRI findings of ten patients with pathologically confirmed PHNEN were retrospectively analyzed. The result was compared with pathologic features classified by the 2010 WHO classification of gastro-entero-pancreatic neuroendocrine tumor which was also compared with the conventional method. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2017.08.008DOI Listing
August 2017
5 Reads

Cushing's syndrome secondary to typical pulmonary carcinoid with mutation in BCOR gene: A case report.

Medicine (Baltimore) 2017 Aug;96(34):e7870

aDepartment of Thoracic Surgery, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou b3D Medicines Corporation, Shanghai, China.

Rationale: Typical pulmonary carcinoid is a kind of low-grade malignancy neuroendocrine tumor. Cushing's syndrome is a very rare clinical feature of typical pulmonary carcinoid caused by hypercorticism. Complete tumor resection is the standard curative treatment for primary typical pulmonary carcinoid. Read More

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http://dx.doi.org/10.1097/MD.0000000000007870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572024PMC
August 2017
25 Reads

Natural History of Localized and Locally Advanced Atypical Lung Carcinoids after Complete Resection: A Joined French-Italian Retrospective Multicenter Study.

Neuroendocrinology 2018 17;106(3):264-273. Epub 2017 Aug 17.

Background: The natural history and the best modality of follow-up of atypical lung carcinoids (AC) remain ill defined. The aim of this study was to analyze recurrence-free survival (RFS) after complete resection (R0) of stage I-III pulmonary AC. Secondary objectives were prognostic parameters, the location of recurrences, and the modality of follow-up. Read More

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http://dx.doi.org/10.1159/000480015DOI Listing
January 2019
33 Reads

Treatment of Lung Carcinosarcoma and Other Rare Histologic Subtypes of Non-small Cell Lung Cancer.

Curr Treat Options Oncol 2017 08 10;18(9):54. Epub 2017 Aug 10.

State Key Laboratory of Oncology in South China, Guangzhou, China.

Opinion Statement: Lung carcinosarcoma (PCS) and other histological subtypes of non-small cell lung cancer, such as primary pulmonary lymphoma (PPL), pulmonary carcinoid (PC), and primary pulmonary lymphoepithelioma-like carcinoma (LELC), are rare. For their low incidence, the diagnosis and treatment are still controversial. Some patients only need surgery, while others may need chemotherapy, radiotherapy, or targeted therapy. Read More

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http://dx.doi.org/10.1007/s11864-017-0494-9DOI Listing
August 2017
5 Reads

Do we really care about incidental lung nodules?-Review of atypical lung carcinoid and a proposal for systematic patient follow up.

Transl Lung Cancer Res 2017 Jun;6(3):387-392

Department of Radiology, Saint Vincent's Medical Center, Bridgeport, CT, USA.

Atypical lung carcinoids are intermediate-grade neuroendocrine tumors (NETs) with malignant potential. They are often detected incidentally on imaging done for non-related causes, as the patients are frequently asymptomatic. Histopathology is required to confirm the diagnosis with immunohistochemistry (IHC). Read More

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http://tlcr.amegroups.com/article/view/13735/11631
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http://dx.doi.org/10.21037/tlcr.2017.05.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504111PMC
June 2017
36 Reads