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Ann Thorac Med 2019 Apr-Jun;14(2):161-163

Department of Medicine, Division of Pulmonary, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNEC) is an abnormal proliferation of pulmonary neuroendocrine cells that occur without underlying etiology. Here, we report a unique case of 55-year-old female with unusual presentation of DIPNECH and thymoma and on the background history of Crohn's disease that might point toward an autoimmune phenomenon. To the best of our knowledge, there were no previous reports of DIPNECH with either thymoma or Crohn's disease. Read More

Turk Patoloji Derg 2019 Apr 12. Epub 2019 Apr 12.

Department of Pathology, Erzurum Regional Training and Research Hospital, ERZURUM, TURKEY.

Bronchial carcinoid tumors are primary lung neoplasms thought to originate from neuroendocrine cells, i.e. Kulchitsky cells, in the bronchial mucosa, although the type of cellular origin has not been clearly understood. Read More

Expert Rev Mol Diagn 2019 Apr 12:1-9. Epub 2019 Apr 12.

a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management , Shri Vile Parle Kelavani Mandal'S Narsee Monjee Institute of Management Studies University , Mumbai , India.

Introduction: Lung cancer (LC) emerges as a principle cause of death among smokers and is also one of the most lethal forms of cancer in nonsmokers. LC is mainly classified as non-small cell lung cancer (NSCLC), small cell LC, and lung carcinoid tumor. NSCLC is the most prevalent form of LC and its early stage diagnosis is essential to reduce mortality rate of patients and provide specific therapy. Read More

Turk Thorac J 2019 Jan 31;20(2):153-156. Epub 2019 Jan 31.

Department of Pulmonary Medicine, Pacific Medical College and Hospital, Udaipur, Rajasthan, India.

A partial or complete resolution of the neoplastic lesion, either spontaneously or in the presence of therapy that is considered inadequate to exert significant influence on the growth of the neoplastic lesion, is considered a spontaneous regression. This phenomenon is extremely rare in lung neoplasms. A close follow up with imaging along with bronchoscopy and a biopsy of the lesion is essential, as they may have potential for distant spread even during radiological regression. Read More

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):270-275

Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

The diagnostic criteria of lung biopsy specimens by 2015 WHO lung tumor classification were used to evaluate lung biopsy specimens along with detection of genetic alterations of major tumor driving genes including epidermal growth factor receptor (EGFR). The clinical data, histological slides, immunohistochemical stains and special stains of 806 lung biopsy specimens at Beijing Hospital from July 2015 to July 2018 were retrospectively analyzed. Diagnosis of lung cancer was reclassified according to the 2015 WHO lung tumor classification and related gene mutation data were analyzed. Read More

J BUON 2019 Jan-Feb;24(1):256-266

Clinic for Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia.

Purpose: Neuroendocrine lung tumors (NET) include typical carcinoids (TC), atypical carcinoids (AC), large cell NE carcinoma (LCNEC) and small-cell carcinoma (SCLC), with different clinicopathological profiles and relative grades of malignancy. Although differences between carcinoids and high grade carcinomas are recognized, precise differences and behavior of TC and AC have not been clearly defined. The aim of this study was to better define the differences in the clinical behavior of TC and AC, and to establish new prognostic factors of overall survival (OS), by determining the levels of genetic expression of IGF1R, ERCC1, Bax, p53, Bcl2 and Bcl2/Bax ratio. Read More

J Am Soc Cytopathol 2019 Jan - Feb;8(1):39-46. Epub 2018 Oct 16.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York.

Introduction: Orthopedia homeobox protein (OTP) was recently demonstrated to be a pulmonary neuroendocrine marker showing specificity for pulmonary carcinoid tumors in histologic sections. Little is known of OTP performance and specificity for pulmonary neuroendocrine tumors in lung fine-needle aspiration (FNA) cell blocks (CBs), however.

Materials And Methods: We evaluated OTP expression in lung non-neuroendocrine and neuroendocrine tumor CBs to determine its diagnostic utility in these specimens. Read More

Mod Pathol 2019 Mar 28. Epub 2019 Mar 28.

Thoracic Oncology Service, Department of Medicine, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

The spectrum and evolution of proliferation rates in stage IV lung carcinoids is poorly defined. In particular, there are limited data on the prevalence and characteristics of tumors exceeding the standard upper proliferative criteria-as defined largely based on early-stage carcinoids-in metastatic setting. Sixty-six patients with stage IV lung carcinoids were identified, and all evaluable samples (n = 132; mean 2 samples per patient) were analyzed for mitotic counts and Ki-67 rate. Read More

Ann Thorac Surg 2019 Mar 22. Epub 2019 Mar 22.

Department of General Surgical Science.

Background: Stathmin-1regulates microtubule dynamics and is associated with malignant phenotypes in non-small-cell lung cancer (NSCLC). This study evaluated its diagnostic value for differentiating between NSCLC and high-grade neuroendocrine tumor (HGNET).

Methods: Stathmin-1 protein expression was assessed by immunohistochemistry (IHC) in surgical specimens of 414 NSCLC (305 adenocarcinoma [AD], 102 squamous cell carcinoma [SCC], 7 large-cell carcinoma [LA]), 5 typical carcinoid (TC; a low-grade neuroendocrine tumor), and 34 HGNET (17 small-cell carcinoma [SCLC] and 17 large-cell neuroendocrine carcinoma [LCNEC]) and biopsy specimens of 57 NSCLCs (29 AD and 28 SCC) and 42 HGNETs (17 LCNEC and 25 SCLC). Read More

Respirol Case Rep 2019 May 7;7(4):e00409. Epub 2019 Mar 7.

Pulmonary and Critical Care University of Maryland School of Medicine Baltimore MD USA.

Organizing pneumonia is a well-known clinical entity resulting in response to noxious stimuli causing lung injury. It is known to occur with infectious disease processes, neoplasms, post lung surgery or radiation therapy and when idiopathic, is called cryptogenic organizing pneumonia. We present an unusual case of a 48-year-old woman who presented with chronic cough and progressive dyspnoea while being on macrolide therapy for Lyme disease. Read More

Radiol Case Rep 2019 May 6;14(5):595-601. Epub 2019 Mar 6.

Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.

Metastatic neuroendocrine tumors of the liver typically appear as solid, hypervascular masses on imaging. Pseudocysts mimicking simple cysts are extremely rare. A 42-year-old Japanese woman was referred with a single pulmonary mass in the left lower lobe. Read More

Medicine (Baltimore) 2019 Mar;98(10):e14769

Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

Background: Pulmonary carcinoids (PC) are histologically classified into typical carcinoid (TC) and atypical carcinoid (AC). The diagnosis of pulmonary carcinoid and possibly the differentiation between TC and AC could make a significant effect on the treatment planning as well as prognosis. Several studies have explored the utility of Ga-DOTA-Peptide (Ga-labelled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-peptide) and F-flurodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in the evaluation of primary pulmonary carcinoids. Read More

Clin Lung Cancer 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY.

Introduction: Surgery is the standard of care for pulmonary carcinoid tumors; however, options for inoperable patients are few. We report the outcomes of inoperable pulmonary carcinoid patients treated with stereotactic body radiotherapy (SBRT).

Patients And Methods: From an institutional database, we retrospectively identified patients treated with SBRT for pulmonary carcinoid tumors from 2007 to 2017. Read More

Transl Oncol 2019 Apr 25;12(4):646-655. Epub 2019 Feb 25.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, PR China. Electronic address:

Background: Large cell neuroendocrine carcinoma (LCNEC) was categorized into pulmonary neuroendocrine tumors (NETs) according to the World Health Organization classification guideline. However, LCNEC patients often received the chemotherapy regimens similar to non-small cell lung carcinoma (NSCLC) in advanced stage and the therapeutic effect was unsatisfactory. Therefore, this study aimed to investigate the hidden clinical features, prognosis and immunoprofile of the LCNEC, compared with carcinoid and SCLC, to explore whether LCNEC shares similarity with SCLC and potential treatment approaches could be revealed. Read More

Chin Med J (Engl) 2019 Mar;132(5):551-561

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Background: Classification of the pulmonary neuroendocrine tumor (pNET) categories is a step-wise process identified by the presence of necrosis and number of mitoses per 2 mm. In neuroendocrine tumor pathology, Ki-67 was first described as a prognostic factor in the pancreas and incorporated into the grading system of digestive tract neuroendocrine neoplasms in the 2010 WHO classification. However, the significance of Ki-67 in pNETs was still a controversial issue. Read More

Chin Med J (Engl) 2019 Feb 20. Epub 2019 Feb 20.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Background: Classification of the pulmonary neuroendocrine tumor (pNET) categories is a step-wise process identified by the presence of necrosis and number of mitoses per 2 mm. In neuroendocrine tumor pathology, Ki-67 was first described as a prognostic factor in the pancreas and incorporated into the grading system of digestive tract neuroendocrine neoplasms in the 2010 WHO classification. However, the significance of Ki-67 in pNETs was still a controversial issue. Read More

BMC Pulm Med 2019 Feb 18;19(1):44. Epub 2019 Feb 18.

1st Respiratory Medicine Department, University of Athens, "Sotiria" Hospital, 152 Mesogeion Ave, 115 27, Athens, Greece.

Background: Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contralateral hemithorax, mimicking the mediastinal shift observed in postpneumonectomy syndrome after pneumonectomy. We report a unique case of postpneumonectomy-like syndrome caused by an atypical bronchial carcinoid completely occluding the left main bronchus.

Case Presentation: A 25-year-old woman presented with symptoms of chronic exertional dyspnea and productive cough. Read More

Kyobu Geka 2019 Feb;72(2):160-163

Department of Thoracic Surgery, Shinkoga Hospital, Kurume, Japan.

A 45-year-old woman, who had been treated for bronchial asthma, was referred to our hospital with symptoms of dyspnea. Upon examination, we found the right main bronchus to be almost completely occluded by an endobronchial tumor. For the purpose of diagnosis and relieving the dyspnea, we performed a rigid bronchoscopic tumor resection with a high frequency snare. Read More

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Service d'Oncologie Médicale, Groupement Hospitalier Centre, Institut de Cancérologie des Hospices Civils de Lyon, Lyon, France; University of Lyon, Lyon, France. Electronic address:

Introduction: Metastatic lung carcinoids (MLCs) remain poorly characterized and no prognostic stratification exists.

Methods: We conducted a retrospective study including patients with MLCs in two European expert centers. The aims were to characterize these cases and to identify prognostic factors of survival and effectiveness of their treatments. Read More

BMC Pulm Med 2019 Feb 15;19(1):41. Epub 2019 Feb 15.

Department of Pulmonary Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Background: Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low among clinicians. The synchronous presentation of lung cancer and mycobacterial infection is well known but the combination of pulmonary carcinoid and mycobacterial infection is rare. Read More

J Thorac Dis 2018 Dec;10(12):6653-6659

Division of Thoracic Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.

Background: Sleeve resection allows for preservation of lung parenchyma and improved long-term outcomes when compared with pneumonectomy. Little is known about minimally invasive sleeve resection, especially indications, feasibility, technical aspects, complications, and outcomes. We reviewed our institutional experience with sleeve resections via a minimally invasive approach. Read More

Ann Endocrinol (Paris) 2019 Apr 29;80(2):137-139. Epub 2019 Jan 29.

Endocrinology, Clinique Saint Luc de Bouge, UCL, 8, rue Saint-Luc, 5004 Bouge, Belgium. Electronic address:

Medicine (Baltimore) 2019 Feb;98(5):e14315

Department of Pathology, the First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang.

Rationale: Sclerosing pneumocytoma accompanied with other type of tumor in one patient is very rare. Here, we report a case of a sclerosing pneumocytoma mixed with a typical carcinoid tumor in a same neoplasm.

Patient Concerns: A 55-year-old woman incidentally detected a space-occupying lesion of right lung in routine health examination. Read More

Iran J Pathol 2018 17;13(2):196-204. Epub 2018 Jul 17.

Registrar Pathology, Apollo Hospitals, Bangalore, Bangalore, India.

Background & Objective: Primary pleural neoplasms are rare entities compared with the pleural involvement by metastatic carcinoma.The current study aimed at investigating the complete spectrum of pleural neoplasms and differentiating between them with the aid of immunohistochemistry (IHC).

Methods: Consecutive pleural biopsy specimens positive for a neoplasm, both primary and metastatic, were included in the study. Read More

Asian Pac J Cancer Prev 2019 Jan 25;20(1):53-57. Epub 2019 Jan 25.

Radiotherapy Development Department in Provincial Multidisciplinary Hospital in Gorzów Wielkopolski, ul Dekerta 1, 66-400 Gorzow Wielkopolski LLC, Poland.

Purpose: This study aimed to evaluate the impact of tumor volume on platelet counts (PLT) and mean platelet volume (MPV) and involve these parameters on overall survival. Methods: It is a retrospective study of 99 patients with lung cancer (confirmed histologically or cytologically). Sixty-six patients underwent radical operating treatment and 33 patients had only biopsies – due to the inoperable status of tumor According to the histopathology profile: non-small cell carcinoma – 23%, adenocarcinoma - 23 %, squamous - 36%, small cell carcinoma -11%, carcinoid – 6%. Read More

J Clin Endocrinol Metab 2019 Jun;104(6):2083-2093

Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Context: Pulmonary carcinoids (PCs) belong to neuroendocrine tumors that often overexpress somatostatin receptors (SSTRs). This overexpression provides a molecular basis for tumor imaging and treatment with somatostatin analogs.

Objective: To evaluate SSTR1 to SSTR5 distribution in a large set of PC tumors and to investigate whether the expression is associated with clinicopathological and outcome data. Read More

Neuroendocrinology 2019 Jan 17. Epub 2019 Jan 17.

University of Warmia and Mazury, Olsztyn, Poland.

Background: There are no effective biomarkers for the management of bronchopulmonary carcinoids (BPC). We examined the utility of a neuroendocrine multigene transcript "liquid biopsy" (NETest) in BPC for diagnosis and monitoring of the disease status.

Aim: To independently validate the utility of the NETest in diagnosis and management of BPC in a multicenter, multinational, blinded study. Read More

Nucl Med Commun 2019 Apr;40(4):353-360

Departments of Endocrinology, Metabolism and Internal Medicine.

Objectives: The aim of this study was to investigate the fluorine-18-fluorodeoxyglucose (F-FDG) uptake on integrated PET [PET/computed tomography (CT)] images and its correlation with nestin expression in a series of neuroendocrine lung tumours. As the incidence of neuroendocrine lung tumours is rising, tools predicting diagnosis, outcome and assisting in the selection of treatment regimens are needed.

Patients And Methods: We reviewed records of patients diagnosed with large cell neuroendocrine lung carcinoma, atypical carcinoid and typical carcinoid who were operated upon in our institution. Read More

Clin Nucl Med 2019 Mar;44(3):e154-e157

Department of Histopathology, HCG Cancer Centre, Bangalore, India.

Atypical lung carcinoids frequently metastasize to mediastinal nodes, liver, bone, lungs, and brain and rarely to ovaries, pancreas, subcutaneous, and skin. Solitary peritoneal metastasis is extremely rare and unreported previously. We present a case of a 36-year-old woman with cough, hemoptysis, dyspnea with detection of lung mass, and incidental detection of pelvic mass. Read More

Oncologist 2019 Jan 4. Epub 2019 Jan 4.

Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

Background: Using data from four tertiary referral centers in the U.S., we assessed real-world treatment patterns and clinical outcomes of patients with advanced lung neuroendocrine tumors (NETs). Read More

Medicine (Baltimore) 2018 Dec;97(52):e13806

Department of Pathology.

Rationale: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare idiopathic disease with only about 100 cases reported in the literature.

Patient Concerns: Here, we presented 4 cases of DIPNECH. Four patients included 2 females and 2 males, aged 54 to 64 years old; 3 had no smoking history and 1 had history of smoking for 30 years. Read More

Kyobu Geka 2018 12;71(13):1097-1101

Department of Thoracic Surgery, Ageo Central General Hospital, Ageo, Japan.

A 17-year-old girl was referred to our hospital with atelectasis of left lung due to tumor occlusion. Clearance of the tumor was performed by mechanical removal and application of Nd-YAG laser or electrocautery. The histopathological diagnosis was typical carcinoid. Read More

Endocr J 2019 Feb 19;66(2):175-180. Epub 2018 Dec 19.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

Cushing's syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing's syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing's syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Read More

J Clin Oncol 2019 Feb 13;37(4):318-327. Epub 2018 Dec 13.

Merck & Co., Inc., Kenilworth, NJ.

Purpose: Biomarkers that can predict response to anti-programmed cell death 1 (PD-1) therapy across multiple tumor types include a T-cell-inflamed gene-expression profile (GEP), programmed death ligand 1 (PD-L1) expression, and tumor mutational burden (TMB). Associations between these biomarkers and the clinical efficacy of pembrolizumab were evaluated in a clinical trial that encompassed 20 cohorts of patients with advanced solid tumors.

Methods: KEYNOTE-028 ( ClinicalTrials. Read More

Cancers (Basel) 2018 Dec 12;10(12). Epub 2018 Dec 12.

Division of Hematology & Oncology, Roswell Park Comprehensive Cancer Center, University at Buffalo School of Medicine, Buffalo, NY 14203, USA.

Neuroendocrine tumors (NETs) are a group of malignancies that originated from neuroendocrine cells, with the most common sites being lungs and the gastrointestinal tract. Lung NETs comprise 25% of all lung malignancies. Small cell lung cancer is the most common form of lung NETs, and other rare forms include well-differentiated typical carcinoids (TCs) and poorly differentiated atypical carcinoids (ACs). Read More

J Thorac Dis 2018 Oct;10(10):5850-5859

Division of Hematology, Oncology, Blood & Marrow Transplantation, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Background: The optimal surgery for resectable pulmonary typical carcinoid (TC), e.g., lobar resection (L-R) sub-lobar resection (SL-R), is controversial. Read More

Neuroendocrinology 2019 28;108(2):109-120. Epub 2018 Nov 28.

Department of Pathology, Technical University Munich, Munich, Germany.

The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67 values that overlap with those of poorly differentiated (PD)-NENs. Resected lung NENs from 244 Japanese patients were reviewed, and Ki67 indices were assessed in all tumors. Read More

J Egypt Natl Canc Inst 2018 Dec 22;30(4):151-158. Epub 2018 Nov 22.

Department of Medical Oncology, National Cancer Institute, Cairo University, Egypt. Electronic address:

Background: The spectrum of lung neuroendocrine tumors (NETs) encompasses low grade typical carcinoid (TC), intermediate grade atypical carcionid (AC) and high grade, both large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC), with extreme differences in management and survival.

Objective: To study clinicopathologic and prognostic factors affecting survival of lung NETs.

Patients And Methods: This is a retrospective study evaluating 35 patients with primary lung NETs treated at National Cancer Institute of Egypt (NCI-E) between January 2010 and December 2014. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13286

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Rationale: Thymic carcinoids are a rare type of malignant neuroendocrine tumors which have a poor prognosis due to their distant metastasis, invasive behaviour, and postoperative recurrence. Surgical resection is still the fundamental mode for treating thymic carcinoids. Here, we report the rapid shrinkage of an atypical thymic carcinoid with multiple metastases following chemoradiation plus octreotide as a first-line therapy PATIENT CONCERNS:: A 39-year-old Chinese man presented with chest tightness, dyspnea with a history of lumbago and untreated malignant thymoma. Read More

Radiographics 2018 Nov-Dec;38(7):2151-2172

From the Department of Radiology and Radiological Sciences (J.P.L., E.M.C.) and Department of Pathology (J.P.L., A.R.H., E.M.C.), Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814; Thoracic Radiology Section (J.P.L., D.M.B.) and Pediatric Radiology Section (D.M.B., E.M.C.), American Institute for Radiologic Pathology, Silver Spring, Md; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pa (D.M.B.); Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Tex (B.W.C.); and Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (M.A.P.).

Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Read More

J Thorac Oncol 2019 Feb 8;14(2):184-192. Epub 2018 Nov 8.

Department of Medicine, Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.

Introduction: The TNM classification for lung cancer, originally designed for NSCLC, is applied to staging of bronchopulmonary carcinoid tumors. The validity of the eighth edition of the staging system for carcinoid tumors has not been assessed. In this study, we evaluated its prognostic accuracy by using data from a large national population-based cancer registry. Read More

J Med Genet 2018 Nov 1. Epub 2018 Nov 1.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Background: Copa syndrome is a rare autosomal dominant disorder with abnormal intracellular vesicle trafficking. The objective of this work is to expand the knowledge about this disorder by delineating phenotypic features of an unreported COPA family.

Methods And Results: A heterozygous missense variant (c. Read More

Chirurgia (Bucur) 2018 Sept-Oct;113(5):712-718

The majority of malignant breast lesions are primary tumors originated from breast tissue. These primary breast cancers usually metastasize to lymph nodes, lungs, bones and brain. Metastases from cancers of other organs to the breast are very rare, but have been encountered in patients with malignant melanoma, carcinoid tumors or lung carcinoma. Read More

Clin Nucl Med 2018 Dec;43(12):e492-e494

Dipartimento di Medicina Sperimentale, Università di Roma "Sapienza".

We report the case of a 43-year-old man with a history of lung carcinoid and a recent detection of thyroid nodules by ultrasound. The cytological analysis raised the suspicion of medullary thyroid carcinoma; however, calcitonin and carcinoembryonic antigen levels were in reference range. Considering the previous diagnosis of lung carcinoid, the patient underwent whole-body Ga-DOTATOC PET/CT. Read More

J Cancer Res Clin Oncol 2018 Dec 20;144(12):2441-2447. Epub 2018 Oct 20.

Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, No. 241, West Huaihai Street, Xuhui District, Shanghai, 200030, China.

Purpose: Small cell lung cancer (SCLC) is considered a systemic disease and surgery is generally not recommended to treat it. High heterogeneity within the tumor and preoperative diagnostic capabilities can sometimes fail to identify SCLC correctly, leading to a subset of unexpected SCLC patients that are diagnosed only after pulmonary resections.

Methods: We retrospectively reviewed the clinical records of patients who were diagnosed as having SCLC only after surgery between 2008 and 2015 at a single institution. Read More

Khirurgiia (Mosk) 2018 (9):46-51

National Medical Endocrinology Research Center of Healthcare Ministry of Russia, Moscow, Russia.

Ectopic ACTH-syndrome is a relatively rare neuroendocrine disease. It is characterized by hypercortisolemia-associated severe complications that justifies need for timely diagnosis and radical therapy. Case report of young patient with ACTH-producing lung tumor is presented. Read More

Diagn Cytopathol 2018 Dec 3;46(12):1010-1014. Epub 2018 Oct 3.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.

Background: Homeobox transcription factors have demonstrated utility in diagnosing neuroendocrine tumors. Orthopedia homeobox protein (OTP) has a well-defined role in embryonic neurodevelopment and has also been described as a prognostic marker in lung neuroendocrine tumors (NET). Additionally, NK6 homeobox-1 (NKX6. Read More

Endocrine 2018 Oct 2. Epub 2018 Oct 2.

1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Objective: Our aim was to assess the prevalence of endocrine paraneoplastic syndromes (EPNS) in neuroendocrine neoplasms (NENs) and estimate its impact on patient outcomes.

Design: This is a retrospective analysis of 834 patients with NENs (611 gastrointestinal, 166 thoracic, 57 of unknown and various other primary origin). We included 719 consecutive NEN patients treated at EKPA-Laiko Hospital, Athens, Greece and 115 patients with lung carcinoid (LC) treated at Uppsala University Hospital, Uppsala, Sweden. Read More

Neuroendocrinology 2018 23;107(4):355-365. Epub 2018 Sep 23.

Department of Medical Sciences, Section of Endocrine Oncology, Uppsala University, Uppsala, Sweden.

Background/aims: Lung carcinoids (LCs) are often diagnosed at an early stage and surgical intervention becomes the next phase of treatment. To date, there is lack of long-term follow-up data after surgery and prognostication based on WHO classification criteria and evolving prognostic markers, particularly the expression of somatostatin receptors (SSR).

Methods: We included 102 consecutive patients (72 women; age at baseline 51 ± 16 years [mean ± SD]) with LCs, who underwent thoracic surgery (n = 99) and/or laser treatment (n = 8). Read More