Search Our Scientific Publications & Authors

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Service d'Oncologie Médicale, Groupement Hospitalier Centre, Institut de Cancérologie des Hospices Civils de Lyon, Lyon, France; University of Lyon, Université Lyon 1, France. Electronic address:

Introduction: Metastatic lung carcinoids (MLC) remain poorly characterized and no prognostic stratification exists.

Methods: We conducted a retrospective study including patients with MLC in two European expert centers. The aims were to characterize these, identify prognostic factors of survival, and effectiveness of their treatments. Read More

BMC Pulm Med 2019 Feb 15;19(1):41. Epub 2019 Feb 15.

Department of Pulmonary Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Background: Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low among clinicians. The synchronous presentation of lung cancer and mycobacterial infection is well known but the combination of pulmonary carcinoid and mycobacterial infection is rare. Read More

J Thorac Dis 2018 Dec;10(12):6653-6659

Division of Thoracic Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.

Background: Sleeve resection allows for preservation of lung parenchyma and improved long-term outcomes when compared with pneumonectomy. Little is known about minimally invasive sleeve resection, especially indications, feasibility, technical aspects, complications, and outcomes. We reviewed our institutional experience with sleeve resections via a minimally invasive approach. Read More

Ann Endocrinol (Paris) 2019 Jan 29. Epub 2019 Jan 29.

Endocrinology, Clinique Saint Luc de Bouge, UCL, 8, rue Saint-Luc, 5004 Bouge, Belgium. Electronic address:

Medicine (Baltimore) 2019 Feb;98(5):e14315

Department of Pathology, the First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang.

Rationale: Sclerosing pneumocytoma accompanied with other type of tumor in one patient is very rare. Here, we report a case of a sclerosing pneumocytoma mixed with a typical carcinoid tumor in a same neoplasm.

Patient Concerns: A 55-year-old woman incidentally detected a space-occupying lesion of right lung in routine health examination. Read More

Iran J Pathol 2018 17;13(2):196-204. Epub 2018 Jul 17.

Registrar Pathology, Apollo Hospitals, Bangalore, Bangalore, India.

Background & Objective: Primary pleural neoplasms are rare entities compared with the pleural involvement by metastatic carcinoma.The current study aimed at investigating the complete spectrum of pleural neoplasms and differentiating between them with the aid of immunohistochemistry (IHC).

Methods: Consecutive pleural biopsy specimens positive for a neoplasm, both primary and metastatic, were included in the study. Read More

Asian Pac J Cancer Prev 2019 Jan 25;20(1):53-57. Epub 2019 Jan 25.

Radiotherapy Development Department in Provincial Multidisciplinary Hospital in Gorzów Wielkopolski, ul Dekerta 1, 66-400 Gorzow Wielkopolski LLC, Poland.

Purpose: This study aimed to evaluate the impact of tumor volume on platelet counts (PLT) and mean platelet volume (MPV) and involve these parameters on overall survival. Methods: It is a retrospective study of 99 patients with lung cancer (confirmed histologically or cytologically). Sixty-six patients underwent radical operating treatment and 33 patients had only biopsies – due to the inoperable status of tumor According to the histopathology profile: non-small cell carcinoma – 23%, adenocarcinoma - 23 %, squamous - 36%, small cell carcinoma -11%, carcinoid – 6%. Read More

J Clin Endocrinol Metab 2019 Jan 16. Epub 2019 Jan 16.

Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Context: Pulmonary carcinoids (PC) belong to neuroendocrine tumors that often overexpress somatostatin receptors (SSTR). This overexpression provides a molecular basis for tumor imaging and treatment with somatostatin analogs.

Objective: To evaluate SSTR1-5 distribution in a large set of PC tumors and to investigate whether the expression is associated with clinicopathological and outcome data. Read More

Nucl Med Commun 2019 Jan 10. Epub 2019 Jan 10.

Departments of Endocrinology, Metabolism and Internal Medicine.

Objectives: The aim of this study was to investigate the fluorine-18-fluorodeoxyglucose (F-FDG) uptake on integrated PET [PET/computed tomography (CT)] images and its correlation with nestin expression in a series of neuroendocrine lung tumours. As the incidence of neuroendocrine lung tumours is rising, tools predicting diagnosis, outcome and assisting in the selection of treatment regimens are needed.

Patients And Methods: We reviewed records of patients diagnosed with large cell neuroendocrine lung carcinoma, atypical carcinoid and typical carcinoid who were operated upon in our institution. Read More

Clin Nucl Med 2019 Mar;44(3):e154-e157

Department of Histopathology, HCG Cancer Centre, Bangalore, India.

Atypical lung carcinoids frequently metastasize to mediastinal nodes, liver, bone, lungs, and brain and rarely to ovaries, pancreas, subcutaneous, and skin. Solitary peritoneal metastasis is extremely rare and unreported previously. We present a case of a 36-year-old woman with cough, hemoptysis, dyspnea with detection of lung mass, and incidental detection of pelvic mass. Read More

Oncologist 2019 Jan 4. Epub 2019 Jan 4.

Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

Background: Using data from four tertiary referral centers in the U.S., we assessed real-world treatment patterns and clinical outcomes of patients with advanced lung neuroendocrine tumors (NETs). Read More

Medicine (Baltimore) 2018 Dec;97(52):e13806

Department of Pathology.

Rationale: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare idiopathic disease with only about 100 cases reported in the literature.

Patient Concerns: Here, we presented 4 cases of DIPNECH. Four patients included 2 females and 2 males, aged 54 to 64 years old; 3 had no smoking history and 1 had history of smoking for 30 years. Read More

Kyobu Geka 2018 12;71(13):1097-1101

Department of Thoracic Surgery, Ageo Central General Hospital, Ageo, Japan.

A 17-year-old girl was referred to our hospital with atelectasis of left lung due to tumor occlusion. Clearance of the tumor was performed by mechanical removal and application of Nd-YAG laser or electrocautery. The histopathological diagnosis was typical carcinoid. Read More

Endocr J 2018 Dec 19. Epub 2018 Dec 19.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

Cushing's syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing's syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing's syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Read More

J Clin Oncol 2019 Feb 13;37(4):318-327. Epub 2018 Dec 13.

Merck & Co., Inc., Kenilworth, NJ.

Purpose: Biomarkers that can predict response to anti-programmed cell death 1 (PD-1) therapy across multiple tumor types include a T-cell-inflamed gene-expression profile (GEP), programmed death ligand 1 (PD-L1) expression, and tumor mutational burden (TMB). Associations between these biomarkers and the clinical efficacy of pembrolizumab were evaluated in a clinical trial that encompassed 20 cohorts of patients with advanced solid tumors.

Methods: KEYNOTE-028 ( ClinicalTrials. Read More

Cancers (Basel) 2018 Dec 12;10(12). Epub 2018 Dec 12.

Division of Hematology & Oncology, Roswell Park Comprehensive Cancer Center, University at Buffalo School of Medicine, Buffalo, NY 14203, USA.

Neuroendocrine tumors (NETs) are a group of malignancies that originated from neuroendocrine cells, with the most common sites being lungs and the gastrointestinal tract. Lung NETs comprise 25% of all lung malignancies. Small cell lung cancer is the most common form of lung NETs, and other rare forms include well-differentiated typical carcinoids (TCs) and poorly differentiated atypical carcinoids (ACs). Read More

J Thorac Dis 2018 Oct;10(10):5850-5859

Division of Hematology, Oncology, Blood & Marrow Transplantation, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Background: The optimal surgery for resectable pulmonary typical carcinoid (TC), e.g., lobar resection (L-R) sub-lobar resection (SL-R), is controversial. Read More

Neuroendocrinology 2018 Nov 28. Epub 2018 Nov 28.

The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma, have not been investigated so far. The aim of this study was, therefore, to search for lung NENs, which are well-differentiated but show Ki67 values that overlap with those of poorly differentiated NENs (PD-NENs). Resected lung NENs from 244 Japanese patients were reviewed and Ki67 index was assessed in all tumors. Read More

J Egypt Natl Canc Inst 2018 Dec 22;30(4):151-158. Epub 2018 Nov 22.

Department of Medical Oncology, National Cancer Institute, Cairo University, Egypt. Electronic address:

Background: The spectrum of lung neuroendocrine tumors (NETs) encompasses low grade typical carcinoid (TC), intermediate grade atypical carcionid (AC) and high grade, both large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC), with extreme differences in management and survival.

Objective: To study clinicopathologic and prognostic factors affecting survival of lung NETs.

Patients And Methods: This is a retrospective study evaluating 35 patients with primary lung NETs treated at National Cancer Institute of Egypt (NCI-E) between January 2010 and December 2014. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13286

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Rationale: Thymic carcinoids are a rare type of malignant neuroendocrine tumors which have a poor prognosis due to their distant metastasis, invasive behaviour, and postoperative recurrence. Surgical resection is still the fundamental mode for treating thymic carcinoids. Here, we report the rapid shrinkage of an atypical thymic carcinoid with multiple metastases following chemoradiation plus octreotide as a first-line therapy PATIENT CONCERNS:: A 39-year-old Chinese man presented with chest tightness, dyspnea with a history of lumbago and untreated malignant thymoma. Read More

Radiographics 2018 Nov-Dec;38(7):2151-2172

From the Department of Radiology and Radiological Sciences (J.P.L., E.M.C.) and Department of Pathology (J.P.L., A.R.H., E.M.C.), Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814; Thoracic Radiology Section (J.P.L., D.M.B.) and Pediatric Radiology Section (D.M.B., E.M.C.), American Institute for Radiologic Pathology, Silver Spring, Md; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pa (D.M.B.); Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Tex (B.W.C.); and Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (M.A.P.).

Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Read More

J Thorac Oncol 2019 Feb 8;14(2):184-192. Epub 2018 Nov 8.

Department of Medicine, Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.

Introduction: The TNM classification for lung cancer, originally designed for NSCLC, is applied to staging of bronchopulmonary carcinoid tumors. The validity of the eighth edition of the staging system for carcinoid tumors has not been assessed. In this study, we evaluated its prognostic accuracy by using data from a large national population-based cancer registry. Read More

J Med Genet 2018 Nov 1. Epub 2018 Nov 1.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Background: Copa syndrome is a rare autosomal dominant disorder with abnormal intracellular vesicle trafficking. The objective of this work is to expand the knowledge about this disorder by delineating phenotypic features of an unreported COPA family.

Methods And Results: A heterozygous missense variant (c. Read More

Chirurgia (Bucur) 2018 Sept-Oct;113(5):712-718

The majority of malignant breast lesions are primary tumors originated from breast tissue. These primary breast cancers usually metastasize to lymph nodes, lungs, bones and brain. Metastases from cancers of other organs to the breast are very rare, but have been encountered in patients with malignant melanoma, carcinoid tumors or lung carcinoma. Read More

Clin Nucl Med 2018 Dec;43(12):e492-e494

Dipartimento di Medicina Sperimentale, Università di Roma "Sapienza".

We report the case of a 43-year-old man with a history of lung carcinoid and a recent detection of thyroid nodules by ultrasound. The cytological analysis raised the suspicion of medullary thyroid carcinoma; however, calcitonin and carcinoembryonic antigen levels were in reference range. Considering the previous diagnosis of lung carcinoid, the patient underwent whole-body Ga-DOTATOC PET/CT. Read More

J Cancer Res Clin Oncol 2018 Dec 20;144(12):2441-2447. Epub 2018 Oct 20.

Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, No. 241, West Huaihai Street, Xuhui District, Shanghai, 200030, China.

Purpose: Small cell lung cancer (SCLC) is considered a systemic disease and surgery is generally not recommended to treat it. High heterogeneity within the tumor and preoperative diagnostic capabilities can sometimes fail to identify SCLC correctly, leading to a subset of unexpected SCLC patients that are diagnosed only after pulmonary resections.

Methods: We retrospectively reviewed the clinical records of patients who were diagnosed as having SCLC only after surgery between 2008 and 2015 at a single institution. Read More

Khirurgiia (Mosk) 2018 (9):46-51

National Medical Endocrinology Research Center of Healthcare Ministry of Russia, Moscow, Russia.

Ectopic ACTH-syndrome is a relatively rare neuroendocrine disease. It is characterized by hypercortisolemia-associated severe complications that justifies need for timely diagnosis and radical therapy. Case report of young patient with ACTH-producing lung tumor is presented. Read More

Diagn Cytopathol 2018 Dec 3;46(12):1010-1014. Epub 2018 Oct 3.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.

Background: Homeobox transcription factors have demonstrated utility in diagnosing neuroendocrine tumors. Orthopedia homeobox protein (OTP) has a well-defined role in embryonic neurodevelopment and has also been described as a prognostic marker in lung neuroendocrine tumors (NET). Additionally, NK6 homeobox-1 (NKX6. Read More

Endocrine 2018 Oct 2. Epub 2018 Oct 2.

1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Objective: Our aim was to assess the prevalence of endocrine paraneoplastic syndromes (EPNS) in neuroendocrine neoplasms (NENs) and estimate its impact on patient outcomes.

Design: This is a retrospective analysis of 834 patients with NENs (611 gastrointestinal, 166 thoracic, 57 of unknown and various other primary origin). We included 719 consecutive NEN patients treated at EKPA-Laiko Hospital, Athens, Greece and 115 patients with lung carcinoid (LC) treated at Uppsala University Hospital, Uppsala, Sweden. Read More

Neuroendocrinology 2018 23;107(4):355-365. Epub 2018 Sep 23.

Department of Medical Sciences, Section of Endocrine Oncology, Uppsala University, Uppsala, Sweden.

Background/aims: Lung carcinoids (LCs) are often diagnosed at an early stage and surgical intervention becomes the next phase of treatment. To date, there is lack of long-term follow-up data after surgery and prognostication based on WHO classification criteria and evolving prognostic markers, particularly the expression of somatostatin receptors (SSR).

Methods: We included 102 consecutive patients (72 women; age at baseline 51 ± 16 years [mean ± SD]) with LCs, who underwent thoracic surgery (n = 99) and/or laser treatment (n = 8). Read More

Clin J Oncol Nurs 2018 Oct;22(5):565-568

Dana-Farber Cancer Institute.

Neuroendocrine tumors (NETs), including gastroenteropancreatic NETs, or GEP-NETs, are heterogenous tumors that arise from diffuse neuroendocrine cells and other organs, such as the lung, ovary, and thyroid. Lutetium Lu 177 dotatate (Lutathera®) is a newly approved targeted therapy for patients with advanced GEP-NETs. Patients treated with octreotide long-acting release may be candidates for this second-line therapy. Read More

Endocr J 2018 Dec 20;65(12):1161-1169. Epub 2018 Sep 20.

Department of Diabetes and Endocrinology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.

Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Read More

World J Oncol 2018 Aug 6;9(4):110-114. Epub 2018 Sep 6.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Bronx Care Health System, Bronx, NY 10457, USA.

Recent advances in imaging techniques led to an increase in the incidence of synchronous and metachronous primary lung cancers due to early detection. Management of these patients is challenging and prognosis depends on the stage of the tumor at initial diagnosis and histological type. A 68-year-old African American male patient with medical history of hypertension and diabetes mellitus presented to our emergency department with right sided chest pain, worsening dyspnea and dry cough of 2-week duration. Read More

Ann Thorac Surg 2018 Sep 12. Epub 2018 Sep 12.

Department of Surgery, Division of Thoracic Surgery. Electronic address:

Tumor lysis syndrome (TLS) is a life-threatening complication comprised of hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia attributed to release of intracellular contents. While traditionally associated with leukemia and lymphoma after chemotherapy, it is known to occur in solid malignancies. We herein report a rare case of this syndrome after resection of bulky carcinoid tumor of the lung. Read More

Respir Med Case Rep 2018 24;25:177-180. Epub 2018 Aug 24.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Southern Illinois University School of Medicine, PO Box 19636, Springfield, IL, 62794, USA.

Background: Cushing's syndrome due to ectopic ACTH secretion has been associated with many cancers; most commonly small cell carcinoma of the lung and bronchial carcinoid tumors. Usually, patients who confer this diagnosis have poor prognosis.

Case Presentation: A 66-year-old female presented with worsening shortness of breath and weakness over three days. Read More

Kyobu Geka 2018 Aug;71(8):593-596

Department of Thoracic Surgery, National Defense Medical Callege, Tokorozawa, Japan.

A 40-year-old male was referred to our hospital because of a nodular shadow detected in the left lower lobe with the tendency to increase gently. Because fluoro-2-deoxy-D-glucose (FDG) uptake was extremely low on a FDG positron emission tomography (PET-CT), the tumor was highly suspected of the benign tumor. Five years later, a follow-up computed tomography (CT) showed the shadow to be enlarged. Read More

Braz J Cardiovasc Surg 2018 Jul-Aug;33(4):398-403

Freeman Hospital Newcastle, United Kingdom of Great Britain and Northern Ireland.

Introduction: Carcinoid heart disease most frequently involves the tricuspid or, more rarely, the pulmonary valve and presents with right heart failure as 5-HT is metabolized by the lung. Left-sided valve involvement is quite rare. We describe our experience of 3 patients presenting with heart failure secondary to carcinoid heart disease affecting all four cardiac valves. Read More

Cell Oncol (Dordr) 2018 Dec 4;41(6):687-691. Epub 2018 Sep 4.

Division of Pathology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Milan, Via Francesco Sforza 35, 20122, Milan, Italy.

Purpose: Neuroendocrine tumors of the lung (LNETs) encompass a heterogeneous group of lesions, including tumors with no or low metastatic potential, such as typical (TCs) and atypical (ACs) carcinoids, and highly aggressive neuroendocrine carcinomas. To date, only a few biomarkers with prognostic impact have been identified in LNETs. Previous experimental studies have suggested that the cytokine CXCL12 might have a role in stratifying the outcome of lung cancer as well as LNET patients. Read More

J Thorac Dis 2018 Jul;10(7):3928-3939

Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, Milan, Italy.

Background: Broncho-pulmonary neuroendocrine tumors (bpNETs) are rare malignancies and there is no consensus on therapeutical management of metastatic disease and follow-up after radical resection.

Methods: Clinical records of patients with a cytological or histological diagnosis of bpNETs and distant metastases (metachronous or synchronous), evaluated at the European Institute of Oncology between 1997 and 2014, were retrospectively analyzed. Data on patient demographics, pathology, imaging exams, surgical and non-surgical treatments were collected. Read More

Lung India 2018 Sep-Oct;35(5):411-416

Department of Interventional Pulmonology and Sleep Medicine, Royal Care Super Speciality Hospital, Coimbatore, Tamil Nadu, India.

We report the case of a 58-year-old female presenting with central airway obstruction leading to airway compromise thrice, first two times from endobronchial growth of typical carcinoid tissue and subsequently from granulation tissue at anastomotic site after left carinal pneumonectomy. Bronchoscopic resection of carcinoid tumor and granulation tissue was performed successfully with electrosurgical snaring through rigid bronchoscope. Cryodebridement using flexible cryoprobe of the tumor was done postembolization and of the remnant granulation tissue without any complication. Read More

Oncologist 2018 Aug 29. Epub 2018 Aug 29.

Memorial Sloan Kettering Cancer Center, New York, New York, USA

Background: The clinical relevance of molecular biomarkers in oncology management has been recognized in breast and lung cancers. We evaluated a blood-based multigene assay for management of neuroendocrine tumors (NETs) in a real-world study (U.S. Read More

Onco Targets Ther 2018 17;11:4991-4998. Epub 2018 Aug 17.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China,

Driver mutations involving tyrosine kinase receptors play crucial roles in the oncogenesis of lung adenocarcinoma. However, receptor tyrosine kinase mutations are extremely rare events in primary pulmonary neuroendocrine carcinoma (NEC), which is a molecular heterogeneous entity. In this study, we examined 4 cases of NEC with anaplastic lymphoma kinase () rearrangement between 2008 and 2018 at our hospital. Read More

Mod Pathol 2019 Jan 28;32(1):100-109. Epub 2018 Aug 28.

Department of Pathology, Cleveland Clinic, Cleveland, OH, USA.

Recent evidence suggests a role for the nuclear marker INSM1 in the diagnosis of neuroendocrine lung neoplasms. The aim of this study was to determine the utility of INSM1 as a marker of neuroendocrine differentiation using a large series of whole-tissue sections of primary lung neoplasms. We stained 345 primary lung neoplasms with INSM1, including 292 whole-tissue sections. Read More

Medicine (Baltimore) 2018 Aug;97(34):e11924

Division of Radiology.

We sought to assess the use of an electro pulmonary nodule (EPN) scanner (FreshMedx, Salt Lake City, UT) in the noninvasive characterization of pulmonary nodules using transcutaneous bioconductance.Monocentric prospective study including patients with a pulmonary nodule identified on a chest computed tomography scan. Study protocol approved by the institutional review board and written consent was obtained for every patient. Read More

Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):81-90

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: The purpose of this study is to evaluate patients with uveal metastasis based on primary tumor site.

Methods: Retrospective analysis from Wills Eye Hospital, Philadelphia, PA, USA, for uveal metastasis clinical features and outcomes based on the primary tumor site.

Results: There were 2214 uveal metastases diagnosed in 1111 consecutive patients. Read More

Oncologist 2019 Jan 13;24(1):54-61. Epub 2018 Aug 13.

H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.

Neuroendocrine neoplasms (NEN) most commonly arise in the gastroenteropancreatic system and lungs. The incidence of NEN is increasing globally, with improved diagnostic techniques identifying patients with early-stage disease. The number of approved therapies for the treatment of advanced disease has grown substantially in the past decade. Read More

Endocrinol Metab Clin North Am 2018 09;47(3):699-709

Upper Aerodigestive Cancer Program, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Carcinoids of the lung and thymus are rare thoracic cancers. In general, lung carcinoid tumors have a favorable prognosis, particularly when diagnosed at an early stage and treated with surgical resection. Thymic neuroendocrine tumors may be associated with multiple endocrine neoplasia-1 syndrome, tend to have a more aggressive natural history, and relatively frequently secrete ectopic adrenocorticotropic hormone. Read More

Interact Cardiovasc Thorac Surg 2019 Feb;28(2):247-252

Department of Thoracic Surgery, University of Health Sciences, Dr Suat Seren Chest Diseases and Surgery, Medical Practice and Research Center, Izmir, Turkey.

Objectives: Pathological N2 (pN2) involvement has a negative impact on prognosis in patients operated on due to non-small-cell lung cancer (NSCLC). pN2 disease may cause skip (pN0N2) or non-skip (pN1N2) metastases with pathological N1 (pN1) involvement. The effect of pN2 subgroups on prognosis is still controversial. Read More

Hum Pathol 2018 Dec 31;82:282-288. Epub 2018 Jul 31.

Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA.

Targeted inhibition of programmed cell death-1 (PD-1) and its ligand (PD-L1) has emerged as first-line therapy for advanced non-small cell lung cancer. Although patients with high PD-L1 expression have improved outcomes with anti-PD-1/PD-L1-directed therapies, use as a predictive biomarker is complicated by robust responses in some patients with low-level expression. Furthermore, reported PD-L1 levels in lung cancers vary widely, and discrepancies exist with different antibodies. Read More