28,779 results match your criteria Lung Cancer Staging


Lung Cancer And Radiological Imaging.

Curr Radiopharm 2020 May 23. Epub 2020 May 23.

Ospedale San Giovanni e Paolo, ULSS 3 Veneziana, Venezia. Italy.

Background: Lung cancer is the neoplasm with the highest prevalence and mortality rates in the world. Most patients with lung cancer that are symptomatic have hemoptysis, coughing, shortness of breath, chest pain and persistent infections. Less than 10% of patients are asymptomatic when the tumor is detected as an incidental finding. Read More

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http://dx.doi.org/10.2174/1874471013666200523161849DOI Listing

Support Vector Machine for Lung Adenocarcinoma Staging Through Variant Pathways.

G3 (Bethesda) 2020 May 22. Epub 2020 May 22.

Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine)

Lung adenocarcinoma (LUAD) is one of the most common malignant tumors. How to effectively diagnose LUAD at an early stage and make an accurate judgement of the occurrence and progression of LUAD are still the focus of current research. Support vector machine (SVM) is one of the most effective methods for diagnosing LUAD of different stages. Read More

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http://dx.doi.org/10.1534/g3.120.401207DOI Listing

Ultrasensitive detection of malignant melanoma using PET molecular imaging probes.

Proc Natl Acad Sci U S A 2020 May 21. Epub 2020 May 21.

Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, 58128 Hwasun, Korea;

Malignant melanoma has one of the highest mortality rates of any cancer because of its aggressive nature and high metastatic potential. Clinical staging of the disease at the time of diagnosis is very important for the prognosis and outcome of melanoma treatment. In this study, we designed and synthesized the F-labeled pyridine-based benzamide derivatives -(2-(dimethylamino)ethyl)-5-[F]fluoropicolinamide ([F]DMPY2) and -(2-(dimethylamino)ethyl)-6-[F]fluoronicotinamide ([F]DMPY3) to detect primary and metastatic melanoma at an early stage and evaluated their performance in this task. Read More

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http://dx.doi.org/10.1073/pnas.1922313117DOI Listing

The Quality of Peer-Reviewed Publications on Surgery for Early Stage Lung Cancer within the Veterans Health Administration.

Semin Thorac Cardiovasc Surg 2020 May 17. Epub 2020 May 17.

Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, 30322; Department of Radiation Oncology, Atlanta VA Health Care System, Decatur, GA, 30333. Electronic address:

The peer-reviewed literature is often referenced to generalize outcomes for lung cancer surgeries performed within the Veterans Health Administration (VHA) and include assessments following resection of early stage non-small cell lung cancer. We sought to determine the reliability of these reports that are publicly available. A systematic review was undertaken to identify PubMed indexed articles that report post-operative outcomes following surgical resections for stage I NSCLC within the VHA. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2020.04.004DOI Listing

Evaluation of nutritional status in non-small-cell lung cancer: screening, assessment and correlation with treatment outcome.

ESMO Open 2020 May;5(3)

Section of Oncology, Department of Medicine, University of Verona, Azienda Ospedaliera Universitaria Integrata (AOUI) di Verona, Verona, Italy

BackgroundNutritional derangements are common hallmarks of non-small-cell lung cancer (NSCLC). Nevertheless, their early detection is overlooked in clinical routine. This study aimed to evaluate nutritional status and its correlation with outcome in NSCLC patients. Read More

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http://dx.doi.org/10.1136/esmoopen-2020-000689DOI Listing

Prophylactic Cranial Irradiation for Small-Cell Lung Cancer: Time for a Reassessment.

Authors:
Martin J Edelman

Am Soc Clin Oncol Educ Book 2020 May;40:24-28

Fox Chase Cancer Center, Philadelphia, PA.

Prophylactic cranial irradiation (PCI) has been an accepted part of the management of both limited and small-cell lung cancer; however, the data that support its use in limited-stage disease is based on an analysis of trials done before currently accepted approaches to staging (i.e., brain MRI and/or PET scanning) were available. Read More

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http://dx.doi.org/10.1200/EDBK_281041DOI Listing

Metachronous primary lung adenocarcinomas harboring distinct KRAS mutations.

Thorac Cancer 2020 May 16. Epub 2020 May 16.

Department of Thoracic Surgery, Second Xiangya Hospital of Central South University, Changsha, China.

To distinguish whether multiple lung nodules represent multiple primary lung cancers (MPLC) or intrapulmonary metastases (IPM) is crucial for staging and subsequent therapy. We herein present the first report of a patient with two simultaneously resected metachronous lung adenocarcinomas in the right upper lobe, each with a distinct driver mutation in the KRAS gene identified by targeted next generation sequencing (NGS). The nodules appeared chronologically metachronous, with a 3. Read More

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http://dx.doi.org/10.1111/1759-7714.13458DOI Listing

Values of different specimen preparation methods for the diagnosis of lung cancer by endobronchial ultrasound guided transbronchial needle aspiration.

BMC Pulm Med 2020 May 15;20(1):140. Epub 2020 May 15.

Department of Respiratory Medicine, Tai Zhou Hospital of Zhejiang Province, LinHai, Zhejiang, P. R. China.

Background: Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has been become an important procedure for the diagnosis and staging of lung cancer. Our research identified the effects of different pathological preparation on the diagnosis of lung cancer for specimens obtained by biopsy.

Methods: Patients were clinically considered if lung cancer was accompanied by mediastinal or hilar lymph node enlargement between March 2014 and November 2017. Read More

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http://dx.doi.org/10.1186/s12890-020-01183-xDOI Listing

Predictors of patient preference for either whole body magnetic resonance imaging (WB-MRI) or CT/ PET-CT for staging colorectal or lung cancer.

J Med Imaging Radiat Oncol 2020 May 14. Epub 2020 May 14.

Centre for Medical Imaging, University College London, Charles Bell House, UK.

Introduction: Whole body magnetic resonance imaging (WB-MRI) may be more efficient in staging cancers, but can be harder for patients to tolerate. We examined predictors of patient preference for WB-MRI vs. CT/ PET-CT for staging colorectal or lung cancer. Read More

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http://dx.doi.org/10.1111/1754-9485.13038DOI Listing

Multimodality treatment including surgery for primary pulmonary sarcoma: Size does matter.

J Surg Oncol 2020 May 14. Epub 2020 May 14.

Department of Thoracic Surgery, University of Duisburg-Essen, Ruhrlandklinik, Essen, Germany.

Background And Objectives: Primary pulmonary sarcoma (PPS) accounts for less than 1.1% of all pulmonary tumors. Few outcome data are reported. Read More

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http://dx.doi.org/10.1002/jso.25979DOI Listing

Safe performance of diagnostic bronchoscopy/EBUS during the SARS-CoV-2 pandemic.

Respirology 2020 May 13. Epub 2020 May 13.

Department of Thoracic Medicine, The University of Adelaide, Royal Adelaide Hospital, Adelaide, SA, Australia.

The SARS-CoV-2 pandemic is unprecedented in our professional lives and much effort and resources will be devoted to care of patients (and HCW) affected by this illness. We must also continue to aim for the same standard of care for our non-COVID respiratory patients, while minimizing risks of infection transmission to our colleagues. This commentary addresses the key paired issues of minimizing performance of diagnostic/staging bronchoscopy in patients with suspected/known lung cancer while maximizing the safety of the procedure with respect to HCW transmission of COVID-19. Read More

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http://dx.doi.org/10.1111/resp.13843DOI Listing

Lung Cancer Staging.

Authors:
Lynn T Tanoue

Clin Chest Med 2020 Jun;41(2):161-174

Yale School of Medicine, 333 Cedar Street, PO Box 208057, New Haven, CT 06520, USA. Electronic address:

Anatomic staging is a critical step in evaluation of patients with lung cancer. Accurate identification of stage based on features of primary tumor (T), regional nodes (N), and metastatic disease (M) is fundamental to determining appropriate care. In this article, the TNM components of the anatomic staging system and a framework for description of lung cancer with multiple pulmonary sites of involvement are discussed. Read More

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http://dx.doi.org/10.1016/j.ccm.2020.02.006DOI Listing

Preliminary Presentation of Metastatic Non-Small Cell Carcinoma of the Lung as Atraumatic Avulsion Fracture of the Lesser Trochanter.

Case Rep Oncol 2020 Jan-Apr;13(1):436-441. Epub 2020 Apr 21.

Orthopaedic Department, Queen Elizabeth Hospital, Gateshead, United Kingdom.

Traumatic avulsion fractures of the lesser trochanter are usually seen along with fractures of the proximal femur and with young adolescents involved in high-intensity sporting injuries. Atraumatic isolated lesser trochanter avulsion in adults are most commonly associated with malignancy. We describe a case of a female in her sixties who was previously fit and healthy with no systemic illness and no history of trauma presenting with groin pain. Read More

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http://dx.doi.org/10.1159/000506451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204840PMC

Mediastinal Up-Staging During Surgery in Non-Small-Cell Lung Cancer: Which Mediastinal Lymph Node Metastasis Patterns Better Predict The Outcome? A Multicenter Analysis.

Clin Lung Cancer 2020 Mar 20. Epub 2020 Mar 20.

Thoracic Surgery, Regina Elena National Cancer Institute, Rome, Italy.

Background: Unexpected N2 involvement occurs in approximately 10% to 20% of patients with non-small-cell lung cancer (NSCLC) and patients' prognostic factors remain unclear. The aim of this study was to evaluate prognostic factors in these patients.

Methods: From January 2002 to December 2012, we retrospectively analyzed data of 550 patients with NSCLC with preoperative negative, but pathologic positive N2 involvement, who underwent anatomical lung resection and hilo-mediastinal lymphadenectomy, obtained from 6 institutions. Read More

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http://dx.doi.org/10.1016/j.cllc.2020.03.004DOI Listing

Overuse of Diagnostic Brain Imaging Among Patients With Stage IA Non-Small Cell Lung Cancer.

J Natl Compr Canc Netw 2020 May;18(5):547-554

4The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Among patients diagnosed with stage IA non-small cell lung cancer (NSCLC), the incidence of occult brain metastasis is low, and several professional societies recommend against brain imaging for staging purposes. The goal of this study was to characterize the use of brain imaging among Medicare patients diagnosed with stage IA NSCLC.

Methods: Using data from linked SEER-Medicare claims, we identified patients diagnosed with AJCC 8th edition stage IA NSCLC in 2004 through 2013. Read More

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http://dx.doi.org/10.6004/jnccn.2019.7384DOI Listing

MicroRNA-597 inhibits NSCLC progression through negatively regulating CDK2 expression.

Authors:
D-J Yu Y-H Li M Zhong

Eur Rev Med Pharmacol Sci 2020 Apr;24(8):4288-4297

Department of Respiration, China Japan Union Hospital of Jilin University, Changchun, China.

Objective: Previous studies have shown that microRNA-597 serves as a tumor suppressor gene. However, the role of microRNA-597 in non-small cell lung cancer (NSCLC) has not been fully elucidated. Therefore, the aim of this study was to investigate the expression of microRNA-597 in NSCLC, and to further explore the possible underlying mechanism. Read More

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http://dx.doi.org/10.26355/eurrev_202004_21009DOI Listing

Stratification of Patients With Stage IB NSCLC Based on the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging Manual.

Front Oncol 2020 21;10:571. Epub 2020 Apr 21.

State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

To assess the postoperative prognosis of patients with stage IB non-small cell lung cancer (NSCLC), using a prognostic model (PM). Patients with stage IB of NSCLC from the two academic databases {the Surveillance, Epidemiology, and End Results [SEER-A, = 1,746 (training cohort)], Sun Yat-sen University Cancer Center [SYSUCC, = 247 (validation cohort)], and SEER-B ( = 1,745)} who had undergone lung surgery from 2001 to 2015 were enrolled. The primary clinical endpoint was cancer-specific survival (CSS). Read More

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http://dx.doi.org/10.3389/fonc.2020.00571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186345PMC

Drug Targeting of Genomic Instability in Multiple Myeloma.

Front Genet 2020 9;11:228. Epub 2020 Apr 9.

Department of Biology, Science & Art Faculty, Burdur Mehmet Akif Ersoy University, Burdur, Turkey.

Genomic instability can be observed at both chromosomal and chromatin levels. Instability at the macro level includes centrosome abnormalities (CA) resulting in numerical as well as structural chromosomal changes, whereas instability at the micro level is characterized by defects in DNA repair pathways resulting in microsatellite instability (MIN) or mutations. Genomic instability occurs during carcinogenesis without impairing survival and growth, though the precise mechanisms remain unclear. Read More

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http://dx.doi.org/10.3389/fgene.2020.00228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179656PMC

A Novel 4-Gene Score to Predict Survival, Distant Metastasis and Response to Neoadjuvant Therapy in Breast Cancer.

Cancers (Basel) 2020 May 2;12(5). Epub 2020 May 2.

Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.

We generated a 4-gene score with genes upregulated in LM2-4, a metastatic variant of MDA-MB-231 (DOK 4, HCCS, PGF, and SHCBP1) that was strongly associated with disease-free survival (DFS) in TCGA cohort (hazard ratio [HR]>1.2, < 0.02). Read More

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http://dx.doi.org/10.3390/cancers12051148DOI Listing

Prognostic Value of Tumor Size in Resected Stage IIIA-N2 Non-Small-Cell Lung Cancer.

J Clin Med 2020 May 1;9(5). Epub 2020 May 1.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan.

The eighth edition of the American Joint Committee on Cancer (AJCC) staging system for lung cancer was introduced in 2017 and included major revisions, especially of stage III. For the subgroup stage IIIA-N2 non-small-cell lung cancer (NSCLC), surgical resection remains controversial due to heterogeneous disease entity. The aim of this study was to evaluate the clinicopathologic features and prognostic factors of patients with completely resected stage IIIA-N2 NSCLC. Read More

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http://dx.doi.org/10.3390/jcm9051307DOI Listing

Stepwise Disease Progression Model of Subsolid Lung Adenocarcinoma with Cystic Airspaces.

Ann Surg Oncol 2020 May 3. Epub 2020 May 3.

Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.

Objectives: Subsolid lung adenocarcinoma with cystic airspaces (LACA) is a unique manifestation of lung cancer. This study was conducted to establish a radiologic disease progression model of LACA and to explore its association with the clinical course and clinicopathologic features of LACA.

Materials And Methods: Sixty patients with LACA who underwent surgery at our center between 2004 and 2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1245/s10434-020-08508-4DOI Listing

Integrated CT imaging and tissue immune features disclose a radio-immune signature with high prognostic impact on surgically resected NSCLC.

Lung Cancer 2020 Jun 21;144:30-39. Epub 2020 Apr 21.

Department of Medicine and Surgery, University of Parma, Medical Oncology Unit, University Hospital of Parma, Via Gramsci 14, 43126, Parma, Italy. Electronic address:

Objectives: Qualitative and quantitative CT imaging features might intercept the multifaceted tumor immune microenvironment (TIME), providing a non-invasive approach to design new prognostic models in NSCLC patients.

Materials And Methods: Our study population consisted of 100 surgically resected NSCLC patients among which 31 served as a validation cohort for quantitative image analysis. TIME was classified according to PD-L1 expression and the magnitude of Tumor Infiltrating Lymphocytes (TILs) and further defined as hot or cold by the tissue analysis of effector (CD8-to-CD3/PD-1-to-CD8) or inert (CD8-to-CD3/PD-1-to-CD8) phenotypes. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.04.006DOI Listing
June 2020
3.958 Impact Factor

Case Report of Immuno-Oncotherapy (IO) Provoked Encephalitis Mimicking Brain Metastasis in a Patient with History of Traumatic Brain Injury.

World Neurosurg 2020 Apr 30. Epub 2020 Apr 30.

Neuroscience Institute; Cancer Institute. Electronic address:

Background: Immuno-oncotherapy (IO) has revolutionized systemic cancer care but remains experimental in brain tumors. IO treatment risks multi-organ autoimmune inflammatory responses that limit its use. The CNS is an immune specialized compartment with restricted cellular access, thus fewer cases reported for immune-mediated encephalitis. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.177DOI Listing

Time trends and predictors of survival in surgically resected early-stage non-small cell lung cancer patients.

J Surg Oncol 2020 Apr 30. Epub 2020 Apr 30.

Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: The improvement in the management of lung cancer have the potential to improve survival in patients undergoing resection for early-stage (stage I and II) non-small cell lung cancer (NSCLC), but few studies have evaluated time trends and identified predictors of overall survival (OS).

Methods: We identified surgically resected early-stage NSCLC between 1998 and 2016. The 3-year OS (1998-2014) and 5-year OS (1998-2012) rates were calculated for each year. Read More

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http://dx.doi.org/10.1002/jso.25966DOI Listing

A retrospective, quantitative assessment of disease burden in patients with leptomeningeal metastases from non-small-cell lung cancer.

Neuro Oncol 2020 May;22(5):675-683

Department of Neurology, New York, New York.

Background: Improvements in detection and molecular characterization of leptomeningeal metastasis from lung cancer (LC-LM) coupled with cerebrospinal fluid (CSF)-penetrating targeted therapies have altered disease management. A barrier to formal study of these therapies in LM is quantification of disease burden. Also, outcomes of patients with targetable mutations in LC-LM are not well defined. Read More

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http://dx.doi.org/10.1093/neuonc/noz208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229251PMC

Results of neoadjuvant chemo(radio)therapy and resection for stage IIIA non-small cell lung cancer in The Netherlands.

Acta Oncol 2020 Apr 29:1-5. Epub 2020 Apr 29.

Department of Surgery, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Concurrent chemoradiotherapy remains the main treatment strategy for patients with stage IIIA non-small cell lung cancer (NSCLC); stage cT3N1 or cT4N0-1 may be eligible for surgery and potentially resectable stage IIIA (N2) NSCLC for neoadjuvant therapy followed by resection. We evaluated treatment patterns and outcomes of patients with stage IIIA NSCLC in The Netherlands. Primary treatment data of patients with clinically staged IIIA NSCLC between 2010 and 2016 were extracted from The Netherlands Cancer Registry. Read More

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http://dx.doi.org/10.1080/0284186X.2020.1757150DOI Listing

The impact of radioactive iodine treatment on survival among papillary thyroid cancer patients according to the 7th and 8th editions of the AJCC/TNM staging system: a SEER-based study.

Updates Surg 2020 Apr 27. Epub 2020 Apr 27.

Department of Nuclear Medicine, Tianjin Medical University General Hospital, Anshan Road No. 154, Heping District, Tianjin, 300052, People's Republic of China.

Papillary thyroid cancer is a very common endocrine malignancy. The 8th American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system introduced major changes. We conducted this retrospective cohort analysis to assess the benefits of radioactive iodine (RAI) according to different stratification of patients. Read More

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http://dx.doi.org/10.1007/s13304-020-00773-yDOI Listing

Neuraxial dysraphism in associated syndrome due to improper mesenchymal transition.

Neurol Genet 2020 Jun 1;6(3):e414. Epub 2020 Apr 1.

National Institutes of Health (J.S.R., A.J.C., H.W., Z.Z.), National Cancer Institute Neuro-Oncology Branch; National Institutes of Health (D.P.A., J.D.H.), National Institute of Neurological Disorders and Stroke, Surgical Neurology Branch; National Institutes of Health (Y.P., A.J., K.P.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Section on Medical Neuroendocrinology; Georgetown Hospital (M.A.N.), Internal Medicine and Pediatrics, Washington DC; National Institutes of Health (J.P.M., D.R.D.), National Institute of Neurological Disorders and Stroke, Mouse Imaging Facility, Bethesda, MD; George Washington University (J.G.S.), Radiology, Washington DC; National Library of Medicine (J.G.S.), MedPix®; National Institutes of Health (M.M.M.), Center for Cancer Research, National Cancer Institute, Laboratory of Pathology; and National Institutes of Health (R.H.K., B.A.K.), National Heart Lung and Blood Institute, Translational Vascular Medicine Branch, Bethesda, MD.

Objective: To investigate the effect of somatic, postzygotic, gain-of-function mutation of Endothelial Per-Arnt-Sim (PAS) domain protein 1 () encoding hypoxia-inducible factor-2α (HIF-2α) on posterior fossa development and spinal dysraphism in gain-of-function syndrome, which consists of multiple paragangliomas, somatostatinoma, and polycythemia.

Methods: Patients referred to our institution for evaluation of new, recurrent, and/or metastatic paragangliomas/pheochromocytoma were confirmed for gain-of-function syndrome by identification of the gain-of-function mutation in resected tumors and/or circulating leukocytes. The posterior fossa, its contents, and the spine were evaluated retrospectively on available MRI and CT images of the head and neck performed for tumor staging and restaging. Read More

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http://dx.doi.org/10.1212/NXG.0000000000000414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164966PMC

Prospective Evaluation of the NETest as a Liquid Biopsy for Gastroenteropancreatic and Bronchopulmonary Neuroendocrine Tumours: An ENETS Centre of Excellence Experience.

Neuroendocrinology 2020 Apr 24. Epub 2020 Apr 24.

Background: There is a substantial unmet clinical need for an accurate and effective blood biomarker for neuroendocrine neoplasms (NEN). We therefore evaluated, under real-world conditions, the clinical utility of the NETest as a liquid biopsy in an ENETS Centre of Excellence and compared its utility with chromogranin A (CgA). Methods Cohorts: Gastroenteropancreatic (GEP)-NEN (n=253), bronchopulmonary (BP)-NEN (n=64), thymic NEN (n=1), colon cancer (n=37), NSCLC (n=63), benign lung disease (n=59) and controls (n=86). Read More

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http://dx.doi.org/10.1159/000508106DOI Listing

Outcomes with segmentectomy versus lobectomy in patients with clinical T1cN0M0 non-small cell lung cancer.

J Thorac Cardiovasc Surg 2020 Mar 23. Epub 2020 Mar 23.

Division of Thoracic Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa. Electronic address:

Objective: We hypothesize that segmentectomy is associated with similar recurrence-free and overall survival when compared with lobectomy in the setting of patients with clinical T1cN0M0 non-small cell lung cancer (NSCLC; >2-3 cm), as defined by the American Joint Committee on Cancer 8th edition staging system.

Methods: We performed a single-institution retrospective study identifying patients undergoing segmentectomy (90) versus lobectomy (279) for T1c NSCLC from January 1, 2003, to December 31, 2016. Univariate, multivariable, and propensity score-weighted analyses were performed to analyze the following endpoints: freedom from recurrence, overall survival, and time to recurrence. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.03.041DOI Listing

[Recent progress of positron radionuclide labeled small molecule inhibitors of prostate specific membrane antigen for PET/CT imaging of prostate cancer].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2020 Apr;37(2):219-224

Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.

Prostate cancer is the most common tumor of the urinary system, and its mortality rate is second only to lung cancer. With the specific and high expression on the surface of prostate cancer cells, prostate-specific membrane antigen (PSMA) has been an ideal theranostic target of prostate cancer with great clinical significance and research value. Positron emission tomography/computed tomography (PET/CT), a new modality of molecular imaging combining functional metabolic information and anatomical structure, provides high diagnostic performance for cancer detection. Read More

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http://dx.doi.org/10.7507/1001-5515.201911073DOI Listing

A national audit of radiology practice in cancer multidisciplinary team meetings.

Clin Radiol 2020 Apr 20. Epub 2020 Apr 20.

Clinical Radiology and Quality Improvement Committee (CRQIC), The Royal College of Radiologists, 63 Lincoln's Inn Fields, London, WC2A 3JW, UK.

Aim: A national audit reviewing compliance of imaging departments with the Royal College of Radiologist (RCR) standards for cancer multidisciplinary team meetings (MDTMs).

Materials And Methods: The audit consisted of a generic and subspecialty component completed for breast, colorectal, and lung cancer MDTMs.

Results: The study achieved the highest response from a RCR national audit with 145/191 (76%) hospitals responding. Read More

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http://dx.doi.org/10.1016/j.crad.2020.03.031DOI Listing

A novel microRNA signature for pathological grading in lung adenocarcinoma based on TCGA and GEO data.

Int J Mol Med 2020 May 4;45(5):1397-1408. Epub 2020 Mar 4.

SJTU‑Yitu Joint Laboratory of Artificial Intelligence in Healthcare, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P.R. China.

Lung adenocarcinoma (LUAD) is one of the most common types of lung cancer and its poor prognosis largely depends on the tumor pathological stage. Critical roles of microRNAs (miRNAs) have been reported in the tumorigenesis and progression of lung cancer. However, whether the differential expression pattern of miRNAs could be used to distinguish early‑stage (stage I) from mid‑late‑stage (stages II‑IV) LUAD tumors is still unclear. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138293PMC

Lung cancer staging: State of the art in the era of ablative therapies and surgical segmentectomy.

Respirology 2020 Apr 22. Epub 2020 Apr 22.

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

Implementation of lung cancer screening and improvements in imaging are expected to increase the proportion of lung cancer diagnosed at an early stage. The standard of care has historically been anatomic lobectomy; however, there is now an array of surgical and non-surgical approaches for management of local disease either in active use or under investigation. By their nature, these new modalities offer a theoretical trade-off of reduced morbidity in exchange for reduced efficacy in the setting of advanced disease. Read More

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http://dx.doi.org/10.1111/resp.13827DOI Listing

Diagnostic Accuracy of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) in Real Life.

Front Med (Lausanne) 2020 7;7:118. Epub 2020 Apr 7.

Department of Pulmonary and Critical Care, Miami VA Medical Center, University of Miami Miller School of Medicine, Miami, FL, United States.

EBUS-TBNA is an integral tool in the diagnosis and staging of lung cancer and other diseases involving mediastinal lymphadenopathy. Most studies attesting to the performance of EBUS-TBNA are prospective analyses performed under strict protocols. The objective of our study was to compare the accuracy of EBUS-TBNA to surgery in diagnosing hilar and mediastinal pathologies in a tertiary hospital, staffed by pulmonologists with and without formal interventional pulmonary training. Read More

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http://dx.doi.org/10.3389/fmed.2020.00118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154097PMC

Clinical significance of serum neuron-specific enolase in gastric adenocarcinoma.

Medicine (Baltimore) 2020 Apr;99(16):e19829

China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.

As a biomarker, neuron-specific enolase (NSE) has been widely recognized in the diagnosis of benign diseases and malignant tumors. This study aimed to investigate the potential diagnostic value of NSE in patients with gastric adenocarcinoma.Serum levels of the NSE were compared between 219 patients with gastric adenocarcinoma and 298 healthy individuals, NSE and clinicopathological parameters were analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000019829DOI Listing

NCAPG Is a Promising Therapeutic Target Across Different Tumor Types.

Front Pharmacol 2020 2;11:387. Epub 2020 Apr 2.

Cell-Gene Therapy Translational Medicine Research Center, Key Laboratory of Liver Disease of Guangdong Province, Guangzhou, China.

Background: With the advent of CRISPR-Cas9 genome editing tool in gene therapy, identification of aberrantly expressed genes is of great value across various cancer types. Since a large number of patients may benefit from molecular targeted gene therapy. The purpose of this study was to identify aberrantly expressed genes across various cancer types, analyze prospective mechanisms and their correlation with survival outcomes. Read More

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http://dx.doi.org/10.3389/fphar.2020.00387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142249PMC

Clinical characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital.

Cancer Biol Med 2020 Feb;17(1):199-207

Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

To evaluate the characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital. Patients with pulmonary nodules 4-25 mm in diameter detected computed tomography (CT) in 2013 were consecutively included. The analysis was restricted to patients with a histological nodule diagnosis or a 2-year follow-up period without nodule growth confirming benign disease. Read More

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http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142837PMC
February 2020

Invasive Staging Procedures Do Not Prevent Nodal Metastases from Being Missed In Stage I Lung Cancer.

Ann Thorac Surg 2020 Apr 10. Epub 2020 Apr 10.

Section of Thoracic Surgery, Department of Surgery, Yale School of Medicine, 330 Cedar St. BB205, PO Box 208062, New Haven, CT 06520-8062. Electronic address:

Background: Up to 20% of clinical stage I lung cancer patients harbor lymph node metastases that go undetected (missed) during the clinical staging evaluation. We investigated to what degree the addition of invasive nodal staging procedures to imaging, as currently practiced, prevents radiographically-occult nodal metastases from being missed during the clinical staging evaluation.

Methods: Treatment-naïve patients, imaged by PET and CT scanning, that underwent lobectomy for clinical stage I lung cancer from 2012-17 in the Society of Thoracic Surgeons General Thoracic Surgery Database were studied. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.03.026DOI Listing

Dynamic chest radiography: Novel and less-invasive imaging approach for preoperative assessments of pleural invasion and adhesion.

Radiol Case Rep 2020 Jun 6;15(6):702-704. Epub 2020 Apr 6.

Department of Thoracic, Cardiovascular and General Surgery, Kanazawa University, Kanazawa, Japan.

Here, we report a case of lung cancer with preoperatively predicted invasion to the parietal pleura on dynamic chest radiography (DCR). An 82-year-old patient was referred for staging of a right lung tumor. Preoperative DCR revealed invasion or adhesion of the tumor to the chest wall, and intraoperative findings revealed invasion of the tumor to the parietal pleura. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138928PMC

Convex probe endobronchial ultrasound: historical, contemporary, and cutting-edge applications.

J Thorac Dis 2020 Mar;12(3):1085-1099

Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.

The use of convex-probe endobronchial ultrasound (CP-EBUS) has revolutionized bronchoscopy. It has provided the option of a relatively safe, minimally invasive approach for the assessment of various intrathoracic diseases. In current practice, its most dramatic impact has been on the diagnosing and staging of lung cancer. Read More

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http://dx.doi.org/10.21037/jtd.2019.10.76DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139045PMC

EUS-B for suspected left adrenal metastasis in lung cancer.

J Thorac Dis 2020 Mar;12(3):258-263

Department of Internal Medicine, Unit of Respiratory Medicine, Zealand University Hospital, Roskilde, Denmark.

Background: Several studies have reported the efficacy of esophageal ultrasound-guided fine needle aspiration (EUS-FNA) for the detection of metastases in the left adrenal gland (LAG) in patients with lung cancer. Currently we have only limited evidence based on small studies on the usefulness of EUS-B [endobronchial ultrasound (EBUS) scope into the esophagus] to provide tissue proof of suspected LAG metastases. The objectives of this study are to investigate feasibility, safety and diagnostic yield of EUS-B-FNA in LAG analysis in patients with proven or suspected lung cancer. Read More

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http://dx.doi.org/10.21037/jtd.2020.01.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139040PMC

USP3 promotes proliferation of non-small cell lung cancer through regulating RBM4.

Eur Rev Med Pharmacol Sci 2020 Mar;24(6):3143-3151

Department of Respiratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

Objective: Previous studies have shown that ubiquitin specific protease 3 (USP3) is an oncogene. However, the role of USP3 in non-small cell lung cancer (NSCLC) has not been reported. This study aims to explore the expression characteristics of USP3 in NSCLC, and its regulation on the proliferative capacity of NSCLC cells. Read More

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http://dx.doi.org/10.26355/eurrev_202003_20681DOI Listing

Inhibition of ALAS1 activity exerts anti-tumour effects on colorectal cancer .

Saudi J Gastroenterol 2020 Apr 6. Epub 2020 Apr 6.

Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, P. R. China.

Background/aims: Colorectal cancer (CRC) is the third most common malignant tumour worldwide and the second leading cause of cancer-related deaths. Commonly, 5'-aminolevulinic acid synthase1 (ALAS1) is the rate-limiting enzyme for haem biosynthesis. Recent studies have shown that ALAS1 is involved in a number of cellular functions and has significant effects on non-small cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.4103/sjg.SJG_477_19DOI Listing

Lymph node assessment in early stage non-small cell lung cancer lymph node dissection or sampling?

Authors:
Gail E Darling

Gen Thorac Cardiovasc Surg 2020 Apr 7. Epub 2020 Apr 7.

Professor of Surgery, Division of Thoracic Surgery, Kress Family Chair in Esophageal Cancer, University of Toronto, University Health Network, Toronto General Hospital, 200 Elizabeth St 9N-955, Toronto, ON, M5G 2C4, Canada.

Lymph node assessment is an essential component of the treatment of lung cancer. Identification of the correct "N" stage is important for staging which in turn determines treatment. Assessment of lymph nodes may be accomplished using imaging with CT scan and PET-CT, invasive techniques such as mediastinoscopy, endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) or endoscopic ultrasound fine needle aspiration (EUS-FNA). Read More

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http://dx.doi.org/10.1007/s11748-020-01345-yDOI Listing

Development of a Survival Prognostic Model for Non-small Cell Lung Cancer.

Front Oncol 2020 20;10:362. Epub 2020 Mar 20.

International Joint Research Laboratory for Cell Medical Engineering of Henan, Huaihe Hospital of Henan University, Kaifeng, China.

Lung cancer is a leading cause of cancer-related death, and >80% of lung cancer diagnoses are non-small-cell lung cancer (NSCLC). However, when using current staging and prognostic indices, the prognosis can vary significantly. In the present study, we calculated a prognostic index for predicting overall survival (OS) in NSCLC patients. Read More

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http://dx.doi.org/10.3389/fonc.2020.00362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098984PMC

Neoadjuvant chemotherapy followed by surgery in lung cancer: Indian scenario.

Curr Probl Cancer 2020 Mar 4:100563. Epub 2020 Mar 4.

Department of Anesthesia, Pain & Palliative care, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

A vast majority of the patients with lung cancer in India present as advanced stage disease and a significant number among them have nonmetastatic locally advanced tumors which require multimodality management with curative intent. We analyzed the treatment outcome of the patients treated with of neoadjuvant chemotherapy followed by surgery approach. This was a retrospective analysis of institutional database of all non-small cell lung cancer patients who underwent neoadjuvant chemotherapy followed by curative intent surgery with/without adjuvant therapy from 2012 to 2018. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2020.100563DOI Listing
March 2020
1.000 Impact Factor

Performance evaluation of developed dedicated breast PET scanner and improvement of the spatial resolution by wobbling: a Monte Carlo study.

Jpn J Radiol 2020 Apr 6. Epub 2020 Apr 6.

Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Molecular imaging, particularly PET scanning, has become an important cancer diagnostic tool. Whole-body PET is not effective for local staging of cancer because of their declining efficiency in detecting small lesions. The preliminary results of the performance evaluation of designed dedicated breast PET scanner presented. Read More

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http://dx.doi.org/10.1007/s11604-020-00966-wDOI Listing

[Risk factors for lung cancer based on low-dose computed tomography screening].

Zhonghua Zhong Liu Za Zhi 2020 Mar;42(3):222-227

PET-CT Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To analyze the risk factors related to lung cancer in participants with low-dose computed tomography (LDCT) screening, to provide data support for identifying high-risk groups of lung cancer and to improve the effectiveness of LDCT lung cancer screening. A total of 5 366 asymptomatic subjects (2 762 males and 2 604 females) who underwent LDCT lung cancer screening were recruited at Cancer Hospital, Chinese Academy of Medical Sciences from 2014 to 2017. The result of LDCT and the risk factors of participants were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-20190809-00509DOI Listing

Primary anatomical site as a prognostic factor for pleomorphic liposarcoma.

J Cancer Res Clin Oncol 2020 Jun 4;146(6):1501-1508. Epub 2020 Apr 4.

Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, 68178, USA.

Background: Pleomorphic liposarcomas (PLS) is an aggressive, high-grade subtype of soft tissue sarcoma representing < 15% of liposarcomas. It most commonly arises in the retroperitoneum and proximal upper extremities. Current prognostic factors are centered around staging, which accounts for the grade, size, and location of the tumor in relation to the superficial fascia. Read More

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http://dx.doi.org/10.1007/s00432-020-03204-yDOI Listing