80,630 results match your criteria Lumbar Spine


Wild-type Transthyretin Amyloidosis Occurring in the Ligamentum Flavum of the Cervicothoracic Spine.

World Neurosurg 2020 Jul 8. Epub 2020 Jul 8.

Tufts Medical Center, Department of Neurosurgery, 800 Washington St, Boston, MA, 02111.

Background: Wild-type transthyretin amyloid (ATTRwt) has been noted to deposit in the ligamentum flavum of the spine. Prior studies have focused on ATTRwt in the lumbar region, but there is a lack of studies discussing its presentation in other levels of the spine. We report on the presentation of patients with confirmed amyloid in the cervicothoracic regions, and discuss the literature to date. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.228DOI Listing

Large Rises in Thoracolumbar Fusions by 2040: A Cause for Concern with an Increasingly Elderly Surgical Population.

World Neurosurg 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurosurgery, Mount Sinai Hospital, New York, NY 10029. Electronic address:

Background: /Objective: With a growing aging population in the United States, the number of operative lumbar spine pathologies continues to grow. Therefore, our objective was to estimate the future demand for lumbar spine surgery volumes for the United States to the year 2040.

Methods: The National/Nationwide Inpatient Sample was queried for years 2003-2015 for anterior interbody and posterior lumbar fusions (ALIF, PLF) to create national estimates of procedural volumes for those years. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.241DOI Listing

Handgrip strength correlates with walking in lumbar spinal stenosis.

Eur Spine J 2020 Jul 10. Epub 2020 Jul 10.

Department of Orthopaedic Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Japan.

Purpose: To examine the relationship between handgrip strength and leg extension power, walking speed, and intermittent claudication for lumbar spinal stenosis (LSS) using computed tomography.

Methods: We examined patients who underwent laminectomy for LSS from June 2015 through March 2018. Before spine surgery, we evaluated walking distance, handgrip strength, leg extension power (LEP), 10-m walk test (time and steps), psoas muscle index (PMI), and the area of both total and multifidus muscle using plain computed tomography imaging at the third lumbar level. Read More

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http://dx.doi.org/10.1007/s00586-020-06525-1DOI Listing

An in vivo study exploring correlations between early-to-moderate disc degeneration and flexion mobility in the lumbar spine.

Eur Spine J 2020 Jul 10. Epub 2020 Jul 10.

Centre for Biomechanics Research, AECC University College, Parkwood Campus, Bournemouth, BH5 2DF, UK.

Purpose: Early disc degeneration (DD) has been thought to be associated with loss of spine stability. However, before this can be understood in relation to back pain, it is necessary to know the relationship between DD and intervertebral motion in people without pain. This study aimed to find out if early-to-moderate DD is associated with intervertebral motion in people without back pain. Read More

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http://dx.doi.org/10.1007/s00586-020-06526-0DOI Listing

"The bent nuns convent". Antipsycotic-induced Pisa Syndrome and Camptocormia.

Neurocirugia (Astur) 2020 Jul 7. Epub 2020 Jul 7.

Servicio de Neurología, Hospital Virgen de la Salud, Toledo, España.

Camptocormia is an involuntary flexion between 15-45° of the thoracolumbar spine when standing, walking or sitting, which disappears completely in the supine position. Is associated to Parkinson's disease and other neurodegenerative conditions, being its physiopatology unknown. We report three cases of atypical anti-psychotic induced camptocormia. Read More

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http://dx.doi.org/10.1016/j.neucir.2020.05.001DOI Listing

Single- versus dual-attending strategy for spinal deformity surgery: 2-year experience and systematic review of the literature.

J Neurosurg Spine 2020 Jul 10:1-12. Epub 2020 Jul 10.

2Neurosurgery, Stanford University Hospitals and Clinics, Stanford, California.

Objective: Adult spinal deformity (ASD) surgery is complex and associated with high morbidity and complication rates. There is growing evidence in the literature for the beneficial effects of an approach to surgery in which two attending physicians rather than a single attending physician perform surgery for and oversee the surgical care of a single patient in a dual-attending care model. The authors developed a dual-attending care collaboration in August 2017 in which a neurosurgeon and an orthopedic surgeon mutually operated on patients with ASD. Read More

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http://dx.doi.org/10.3171/2020.3.SPINE2016DOI Listing

A high-definition 3D exoscope as an alternative to the operating microscope in spinal microsurgery.

J Neurosurg Spine 2020 Jul 10:1-10. Epub 2020 Jul 10.

Objective: Since the 1970s, the operating microscope (OM) has been a standard for visualization and illumination of the surgical field in spinal microsurgery. However, due to its limitations (e.g. Read More

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http://dx.doi.org/10.3171/2020.4.SPINE20374DOI Listing

Convergent Evolution of Swimming Adaptations in Modern Whales Revealed by a Large Macrophagous Dolphin from the Oligocene of South Carolina.

Curr Biol 2020 Jul 1. Epub 2020 Jul 1.

Department of Anatomy, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY 11568, USA.

Modern whales and dolphins are superbly adapted for marine life, with tail flukes being a key innovation shared by all extant species. Some dolphins can exceed speeds of 50 km/h, a feat accomplished by thrusting the flukes while adjusting attack angle with their flippers [1]. These movements are driven by robust axial musculature anchored to a relatively rigid torso consisting of numerous short vertebrae, and controlled by hydrofoil-like flippers [2-7]. Read More

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http://dx.doi.org/10.1016/j.cub.2020.06.012DOI Listing

The lumbar multifidus is characterised by larger type I muscle fibres compared to the erector spinae.

Anat Cell Biol 2020 Jun;53(2):143-150

Department of Rehabilitation Sciences and Physiotherapy, Hasselt University, Rehabilitation Research Centre, Faculty of Rehabilitation Sciences, Diepenbeek, Belgium.

The metabolic capacity of a muscle is one of the determinants of muscle function. Muscle fiber type characteristics give an indication about this metabolic capacity. Therefore it might be expected that the lumbar multifidus (MF) as a local stabilizer contains higher proportions of slow type I fibers, compared to the erector spinae (ES) as a global mobilizer. Read More

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http://dx.doi.org/10.5115/acb.20.009DOI Listing

Combined effect of teriparatide and an anti-RANKL monoclonal antibody on bone defect regeneration in mice with glucocorticoid-induced osteoporosis.

Bone 2020 Jul 6:115525. Epub 2020 Jul 6.

Department of Orthopaedic Surgery, Toyonaka Municipal Hospital, 4-14-1 Shibaharacho, Toyonaka, Osaka 560-8565, Japan.

Objective: The purpose of this study was to examine the effect of single or combination therapy of teriparatide (TPTD) and a monoclonal antibody against the murine receptor activator of nuclear factor κB ligand (anti-RANKL Ab) on cancellous and cortical bone regeneration in a mouse model of glucocorticoid-induced osteoporosis (GIOP).

Methods: C57BL/6 J mice (24 weeks of age) were divided into five groups: (1) the SHAM group: sham operation + saline; (2) the prednisolone (PSL) group: PSL + saline; (3) the TPTD group: PSL + TPTD; (4) the Ab group: PSL + anti-RANKL Ab; and (5) the COMB group: PSL + TPTD + anti-RANKL Ab (n = 8 per group). With the exception of the SHAM group, 7. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115525DOI Listing

Effect of exercise on slowing breastfeeding-induced bone loss: A meta-analysis and trial sequential analysis.

J Obstet Gynaecol Res 2020 Jul 8. Epub 2020 Jul 8.

Division of Experimental Surgery, Department of Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.

Aim: This study systematically reviewed evidence regarding the effectiveness of exercise in slowing breastfeeding-induced bone loss.

Methods: The evidence-based approach of a systematic review (PROSPERO registration No. CRD42019111623) was adopted. Read More

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http://dx.doi.org/10.1111/jog.14346DOI Listing

Effect of Percutaneous Endoscopic Lumbar Foraminoplasty of Different Facet Joint Portions on Lumbar Biomechanics: A Finite Element Analysis.

Orthop Surg 2020 Jul 8. Epub 2020 Jul 8.

Institution of Nurseury, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Objective: To evaluate the influence of percutaneous endoscopic lumbar foraminoplasty of different facet joint portions on segmental range of motion (ROM) and intradiscal pressure (IDP) of L /L and L /L motion segments by establishing three dimensional finite element (FE) model.

Method: Computed tomography images of a male adult volunteer of appropriate age and in good condition both mentally and physically. Obtained data was used in this study from July 2020 to December 2020, and an intact L three dimensional finite element model was successfully constructed using ANSYS and MIMICS software (model M1). Read More

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http://dx.doi.org/10.1111/os.12740DOI Listing

An analysis of osteoporosis in patients with hereditary multiple exostoses.

Osteoporos Int 2020 Jul 8. Epub 2020 Jul 8.

Department of Orthopaedic Surgery, Gifu University, Graduate School of Medicine, 1-1, Yanagido, Gifu, 501-1194, Japan.

We analyzed osteoporosis in 20 HME patients. According to the T-score of BMD, 30% and 67.5% of the patients fell in the range of osteopenia in the lumbar spine and femoral neck. Read More

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http://dx.doi.org/10.1007/s00198-020-05533-7DOI Listing

Risk factors and renal outcomes of low bone mineral density in patients with non-dialysis chronic kidney disease.

Osteoporos Int 2020 Jul 8. Epub 2020 Jul 8.

Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.

Bone disorder is a common complication of chronic kidney disease (CKD). The clinical usefulness of bone mineral density (BMD) in CKD is not well known. Our study shows that low BMD is associated with physical activity and dietary Na/K intake ratio and can predict poor renal outcome in non-dialysis CKD. Read More

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http://dx.doi.org/10.1007/s00198-020-05531-9DOI Listing

A novel system for accurate lumbar spine pedicle screw placement based on three-dimensional computed tomography reconstruction.

J Orthop Translat 2020 Jul 19;23:101-106. Epub 2020 Apr 19.

Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, PR China.

Objectives: The accuracy of pedicle screw placement strongly affects the outcome of spinal surgery and has mainly relied on the surgeons' experience. There is no simple, low-cost, and effective pedicle screw placement system to assist new spinal surgeons with less experience.

Methods: We designed a localization system with six parameters (starting point height [SP-H], starting point length [SP-L], transverse section angle, sagittal section angle [SSA], pedicle width [W] and height [H]) based on preoperative computed tomography reconstruction and combined it with the Roussouly classification to guide lumbar spine pedicle screw placement and analysed the change patterns of the six parameters in 50 participants. Read More

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http://dx.doi.org/10.1016/j.jot.2020.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322241PMC

Reliability of the new modified Moro's classification and oblique corridor grading to assess the feasibility of oblique lumbar interbody fusion.

J Orthop 2020 Sep-Oct;21:321-325. Epub 2020 Jun 6.

Division of Spine, Department of Orthopedic Surgery, Tan Tock Seng Hospital, Singapore.

Introduction: The modified Moro's classification (MMC) of psoas morphology and oblique corridor (OC) grading were recently proposed. Their reliability needs to be tested.

Methods: T2 weighted lumbar disc level axial-cut MRI images of patients with degenerative spondylosis were distributed to five spine surgeons. Read More

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http://dx.doi.org/10.1016/j.jor.2020.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327123PMC

The clinical utility of routine spinal radiographs by chiropractors: a rapid review of the literature.

Chiropr Man Therap 2020 Jul 9;28(1):33. Epub 2020 Jul 9.

Faculty of Health Sciences, Ontario Tech University and Centre for Disability Prevention and Rehabilitation, 2000 Simcoe St N, Oshawa, ON, L1G 0C5, Canada.

Introduction: When indicated by signs or symptoms of potentially serious underlying pathology (red flags), chiropractors can use radiographs to inform their diagnosis. In the absence of red flags, the clinical utility of routine or repeat radiographs to assess the structure and function of the spine is controversial.

Objectives: To determine the diagnostic and therapeutic utility of routine or repeat radiographs (in the absence of red flags) of the cervical, thoracic or lumbar spine for the functional or structural evaluation of the spine. Read More

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http://dx.doi.org/10.1186/s12998-020-00323-8DOI Listing

Mode of onset of dropped head syndrome and efficacy of conservative treatment.

J Orthop Surg (Hong Kong) 2020 Jan-Apr;28(2):2309499020938882

Department of Orthopedic Surgery, Tokyo Medical University, Tokyo, Japan.

Purpose: The initial treatment of dropped head syndrome (DHS) is basically nonsurgical, but the mode of onset of DHS and efficacy of conservative treatment have not been fully clarified.

Methods: The subjects were 38 DHS patients without neuromuscular disease (11 men and 27 women, average age 74.5 years). Read More

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http://dx.doi.org/10.1177/2309499020938882DOI Listing

Invasive liver abscess syndrome accompanied by spondylodiscitis: a case report and review of the literature.

Clin J Gastroenterol 2020 Jul 7. Epub 2020 Jul 7.

Department of Internal Medicine, Nagano Prefectural Kiso Hospital, Kiso, Japan.

A 65-year-old man who had diabetes mellitus was referred to our hospital due to fever and back pain. Laboratory findings showed liver dysfunction and C-reactive protein (CRP) elevation. Enhanced computed tomography (CT) showed multiple liver abscesses, hepatic vein and inferior vena cava thrombosis, and spondylodiscitis in the fourth lumbar vertebrae. Read More

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http://dx.doi.org/10.1007/s12328-020-01161-0DOI Listing

Correction to: Decreasing thickness and remodeling of ligamentum flavum after oblique lumbar interbody fusion.

Neuroradiology 2020 Jul 7. Epub 2020 Jul 7.

Spine Center, Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

In the article "Decreasing Thickness and Remodeling of Ligamentum Flavum After Oblique Lumbar Interbody Fusion", Figure 2 captions contained mistakes as descriptions for the Figure sections were not assigned correctly. Read More

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http://dx.doi.org/10.1007/s00234-020-02454-4DOI Listing
July 2020
2.485 Impact Factor

Magnetic resonance imaging findings in intervertebral disc herniation: Comparison of canal compromise and canal size in patients with and without cauda equina syndrome.

Surg Neurol Int 2020 27;11:171. Epub 2020 Jun 27.

Departments of Spine Service, Indian Spinal Injuries Center, New Delhi, India.

Background: Surgical decompressions are typically warranted in patients with magnetic resonance (MR) and clinical evidence of cauda equina syndromes (CESs). However, it is still unclear what MR findings best correlate with such CES. Here, we compared MR-documented canal size and level/extent of compromise in 52 patients with and 56 others without CES attributed to lumbar disc herniation. Read More

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http://dx.doi.org/10.25259/SNI_242_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332702PMC

Unique Bone Suture Anchor Repair of Complex Lumbar Cerebrospinal Fluid Fistulas.

Surg Neurol Int 2020 13;11:153. Epub 2020 Jun 13.

Departments of Neurosurgery, NYU Winthrop Hospital, Mineola, NY, USA.

Background: Spine surgeons encounter occasional complex cerebrospinal fluid fistulas/dural tears (CSF/DT) during lumbar spinal surgery. In some cases, these leaks are found during the index procedure, but others may appear postoperatively, or in the course of successive procedures. Here we asked, whether these complex CSF fistulas/DT could be more readily repaired utilizing a "bone suture anchor" technique, particularly where there is no residual dural margin/remnant. Read More

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http://dx.doi.org/10.25259/SNI_243_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332496PMC

A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes.

Bone Res 2020 1;8:26. Epub 2020 Jul 1.

Department of Hygiene and Epidemiology, Clinical and Molecular Epidemiology Unit, School of Medicine, University of Ioannina, Ioannina, Greece.

Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural deterioration. Genetic pleiotropy occurs when a single genetic element is associated with more than one phenotype. We aimed to identify pleiotropic loci associated with bone mineral density (BMD) and nonbone phenotypes in genome-wide association studies. Read More

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http://dx.doi.org/10.1038/s41413-020-0101-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329904PMC

[Retrospective study of surgical management of lumbosciatica in the Department of Orthopaedics in Tataouine, Tunisia: about 44 cases].

Pan Afr Med J 2020 7;35:103. Epub 2020 Apr 7.

Service de Chirurgie Orthopédique et Traumatologie, CHU Habib Bourguiba, Sfax, Tunisie.

Lumbosciatica is a public health problem because of its socio-professional impact. The purpose of our study is to evaluate the indication for surgical treatment and the role of each technique used. We conducted a retrospective study in the Department of Orthopaedics in Tataouine. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.103.22510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320770PMC

Posterior short segment pedicle screw fixation for the treatment of thoracolumbar fracture.

Pan Afr Med J 2020 7;35:102. Epub 2020 Apr 7.

Orthopedics and Trauma Department, Habib Bourguiba University Hospital, Sfax, Tunisia.

The choice of the type of stabilization device in the osteosynthesis of dorso-lumbar spine fractures remains a subject of controversy. The present study aims to evaluate the efficiency of short segment in patients suffering post-traumatic thoracolumbar fractures. This study was conducted in the Department of Orthopedic Surgery and Traumatology of the Habib Bourguiba University Hospital, Sfax, Tunisia. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.102.21540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320785PMC

Paraplegia Caused by Spontaneous Spinal Hemorrhage in a Patient Undergoing Rivaroxaban Therapy.

Am J Case Rep 2020 Jul 7;21:e923607. Epub 2020 Jul 7.

Department of Nephrology, Transplantology and Internal Medicine, Independent Public Clinical Hospital No. 2, Szczecin, Poland.

BACKGROUND Spinal hematomas can be post-traumatic, iatrogenic, or spontaneous. A spontaneous spinal hematoma is a rare finding, but one with very serious clinical implications. There are some risk factors linked to its occurrence, e. Read More

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http://dx.doi.org/10.12659/AJCR.923607DOI Listing

Walking and running with non-specific chronic low back pain: What about the lumbar lordosis angle?

J Biomech 2020 Jul 13;108:109883. Epub 2020 Jun 13.

Bern University of Applied Sciences, Department of Health Professions, Division of Physiotherapy, Spinal Movement Biomechanics Group, Bern, Switzerland. Electronic address:

Non-specific chronic low back pain (NSCLBP) is a major health problem, affecting about one fifth of the population worldwide. To avoid further pain or injury, patients with NSCLBP seem to adopt a stiffer movement pattern during everyday living activities. However, it remains unknown how NSCLBP affects the lumbar lordosis angle (LLA) during repetitive activities such as walking or running. Read More

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http://dx.doi.org/10.1016/j.jbiomech.2020.109883DOI Listing

How to improve the safety of bicortical pedicle screw insertion in the thoracolumbar vertebrae: analysis base on three-dimensional CT reconstruction of patients in the prone position.

BMC Musculoskelet Disord 2020 Jul 7;21(1):444. Epub 2020 Jul 7.

Department of Spine Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266555, Shandong, China.

Background: Through the comparison of three-dimensional CT reconstruction between the supine position and the prone position, the relative position of thoracolumbar great vessels and vertebral body was studied, and the shortest safe distance between them was measured to improve the safety of bicortical pedicle screw insertion and reduce the risk of vascular injury.

Methods: Forty adults were selected to participate the research. Three-dimensional reconstruction of thoracolumbar (T9-L3) CT was performed in the prone position and the supine position. Read More

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http://dx.doi.org/10.1186/s12891-020-03473-1DOI Listing

Intervertebral Disc Disease of the Lumbar Spine in Health Personnel with Occupational Exposure to Patient Handling-A Systematic Literature Review and Meta-Analysis.

Int J Environ Res Public Health 2020 Jul 4;17(13). Epub 2020 Jul 4.

Department of Occupational Medicine, Public health and Hazardous Substances, Institution for Statutory Accident Insurance and Prevention in the Health and Welfare Services, 22089 Hamburg, Germany.

Lifting or carrying loads or working while the trunk is in a bent position are well established risk factors for the development of disc disease of the lumbar spine (LDD). Patient handling is associated with certain hazardous activities, which can result in exposure to heavy loads and high pressure for the discs of the lumbar spine of the nurses performing these tasks. The purpose of this review was to examine the occurrence of work-related LDD among health personnel (HP) with occupational exposure to patient handling activities in comparison to un-exposed workers. Read More

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http://dx.doi.org/10.3390/ijerph17134832DOI Listing

Bi-needle technique versus transforaminal endoscopic spine system technique for percutaneous endoscopic lumbar discectomy in treating intervertebral disc calcification: a propensity score matched cohort analysis.

Br J Neurosurg 2020 Jul 7:1-6. Epub 2020 Jul 7.

Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Objective: The aim of this study was to evaluate the clinical results of a Bi-needle technique and conventional transforaminal endoscopic spine system (TESSYS) technique for percutaneous endoscopic lumbar discectomy (PELD) in treating patients with intervertebral disc calcification (IDC).

Background: PELD has gained acceptance for treating patients with IDC. The Bi-needle technique was designed to improve the efficiency and safety of PELD. Read More

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http://dx.doi.org/10.1080/02688697.2020.1784393DOI Listing

Biomechanical evaluation of anterior and posterior lumbar surgical approaches on the adjacent segment: a finite element analysis.

Comput Methods Biomech Biomed Engin 2020 Jul 7:1-8. Epub 2020 Jul 7.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The purpose of this study was to use models of spine to compare range of motion and intradiscal pressure of adjacent segments performing anterior and/or posterior lumbar surgical approaches and predict potential risk of adjacent segment degeneration. A previously validated finite element model of the intact L1-S1 segments was used. Three different anterior and one posterior surgical fixation approaches for tuberculosis were performed in L3-L5. Read More

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http://dx.doi.org/10.1080/10255842.2020.1789605DOI Listing

Cost-effectiveness of adult lumbar scoliosis surgery: an as-treated analysis from the adult symptomatic scoliosis surgery trial with 5-year follow-up.

Spine Deform 2020 Jul 6. Epub 2020 Jul 6.

Duke University Duke Spine Center-Clinic 1B/1C, 40 Duke Medicine Circle, Durham, NC, 27710-400, USA.

Study Design: Longitudinal comparative cohort.

Objective: The purpose of this study is to report on the cost-effectiveness of surgical versus non-surgical treatment for Adult Symptomatic Lumbar Scoliosis (ASLS) using the as-treated data and provide a comparison to previously reported intent-to-treat (ITT) analysis. Adult spinal deformity is a relatively prevalent condition for which surgical treatment has become increasingly common but concerns surrounding complications, revision rates and cost-effectiveness remain unresolved. Read More

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http://dx.doi.org/10.1007/s43390-020-00154-wDOI Listing

Interaction between C/EBPβ and RUNX2 promotes apoptosis of chondrocytes during human lumbar facet joint degeneration.

J Mol Histol 2020 Jul 6. Epub 2020 Jul 6.

Department of Spine Surgery, Nantong City No.1 People's Hospital and Second Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.

The pathophysiological changes in cartilage are a crucial feature of lumbar facet joint (LFJ) degeneration and arthritis. However, the molecular mechanism of human LFJ degeneration remains largely defined. This study aimed to examine the changes in chondrocytes at different stages of degenerative LFJ using hematoxylin and eosin and Safranin O staining. Read More

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http://dx.doi.org/10.1007/s10735-020-09891-8DOI Listing

Cervical sagittal alignment in adolescent high dysplastic developmental spondylolisthesis: how does the cervical spine respond to the reduction of spondylolisthesis?

J Orthop Surg Res 2020 Jul 6;15(1):243. Epub 2020 Jul 6.

Department of Orthopaedics, Peking University Third Hospital, No.49 Huayuan Bei Road, Beijing, 100191, China.

Background: Although pelvic and related parameters have been well stated in lumbar developmental spondylolisthesis, cervical sagittal alignment in these patients is poorly studied, especially in high dysplastic developmental spondylolisthesis (HDDS). The purpose of this study is to investigate the sagittal alignment of the cervical spine in HDDS and how the cervical spine responds to reduction of spondylolisthesis.

Methods: Thirty-three adolescent patients with lumbar developmental spondylolisthesis who received preoperative and postoperative whole-spine x-rays were reviewed. Read More

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http://dx.doi.org/10.1186/s13018-020-01762-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339593PMC

An approximate mathematical model binding the height and position of lumbar vertebrae in the canine spine.

Pol J Vet Sci 2020 Jun;23(2):301-308

Faculty of Veterinary Medicine, Department of Morphological Science, Warsaw University of Life Sciences, Nowoursynowska 166, 02-776, Warsaw, Poland.

The lumbosacral region of the spine is the most susceptible to pathology in large breed dogs. The most common pathologies of this segment include intervertebral disc disease, distortion of vertebrae, narrowing of the lumbosacral canal and congenital defects of the spine. The aim of this study is to develop a mathematical model describing the height of each lumbosacral vertebra in the dog in relation to the position of the vertebra. Read More

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http://dx.doi.org/10.24425/pjvs.2020.133645DOI Listing

Trabecular bone score (TBS) and bone mineral density in patients with long-term therapy with warfarin.

Arch Osteoporos 2020 Jul 6;15(1):102. Epub 2020 Jul 6.

Endocrine Division (SEMPR), Hospital de Clínicas da Universidade Federal do Paraná , Av. Agostinho Leão Junior, 285 - Alto da Glória, Curitiba, PR, 80030-110, Brazil.

In this study, we compared patients using the anticoagulant warfarin for more than a year with a control group with similar characteristics but without using the drug. We demonstrated worse BMD and bone quality by trabecular bone score (TBS) in patients using warfarin for more than 1 year.

Purpose: Evaluate the bone mineral density (BMD) and the trabecular bone score (TBS) of patients taking warfarin for more than 1 year compared with a control group. Read More

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http://dx.doi.org/10.1007/s11657-020-00770-zDOI Listing

Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study.

J Diabetes Res 2020 13;2020:3982831. Epub 2020 Jun 13.

Endocrinology Department, Peking University International Hospital, Beijing, China.

Objective: To analyze the association between uric acid levels and bone mineral density in postmenopausal women with type 2 diabetes mellitus.

Methods: We retrospectively analyzed 262 postmenopausal women with type 2 diabetes mellitus, to assess uric acid levels and bone mineral density using the score of dual-energy X-ray absorptiometry.

Results: (1) Women in the osteoporosis group demonstrated higher uric acid levels and lower estimated glomerular filtration rate ( < 0. Read More

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http://dx.doi.org/10.1155/2020/3982831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313031PMC

Impact of Fat Changes on the Effect of Protease Inhibitors on Lumbar Spine Bone Mineral Density Changes with Antiretroviral Therapy (ART) Initiation.

AIDS Res Hum Retroviruses 2020 Jul 5. Epub 2020 Jul 5.

Johns Hopkins University, 1466, 1830 East Monument Street, Suite 333, Baltimore, Maryland, United States, 21287;

People living with HIV (PLWH) who are on protease inhibitor (PI) containing regimens have been shown to have increases in visceral adipose tissue (VAT) and a greater decrease in spine bone mineral density (BMD) than those receiving non-PI regimens when initiating treatment. This increase in VAT has been hypothesized to falsely lower spine BMD measured via dual-energy X-ray absorptiometry (DXA), suggesting that the PI associated BMD loss is an artefact rather than real. To test this, data collected from two completed 96-week clinical trials, ACTG studies A5224s and A5260s, of ART naïve PLWH initiating treatment with PI and non-PI containing regimens were analyzed comparing VAT accumulation and spine BMD loss. Read More

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http://dx.doi.org/10.1089/AID.2019.0290DOI Listing

Restoration of euthyroidism in women with Hashimoto's thyroiditis changes bone microarchitecture but not estimated bone strength.

Endocrine 2020 Jul 4. Epub 2020 Jul 4.

Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Purpose: Fracture risk in hypothyroid patients is debated, and since the effects of hypothyroidism on bone microarchitecture and strength are unclarified, we investigated these characteristics by high-resolution peripheral quantitative computed tomography (HR-pQCT).

Methods: Two approaches were used: a cross-sectional control study, comparing 32 hypothyroid women (mean age; 47 ± 12 years) suffering from Hashimoto's thyroiditis with 32 sex-, age-, and menopause-matched healthy controls; a prospective study, where 27 of the women were reexamined 1 year after restoration of euthyroidism. HR-pQCT of the distal radius and tibia, and dual-energy X-ray absorptiometry (DXA) of the spine and hip were performed. Read More

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http://dx.doi.org/10.1007/s12020-020-02398-yDOI Listing

A systematic review of developmental lumbar spinal stenosis.

Eur Spine J 2020 Jul 4. Epub 2020 Jul 4.

Department of Orthopaedics and Traumatology, The University of Hong Kong, Professorial Block, 5th Floor, 102 Pokfulam Road, Pokfulam, Hong Kong SAR, China.

Purpose: To systematically evaluate any consensus for the etiology, definition, presentation and outcomes of developmental lumbar spinal stenosis (DLSS).

Methods: A comprehensive literature search was undertaken by 2 independent reviewers with PubMed, Ovid, and Web of Science to identify all published knowledge on DLSS. Search terms included "developmental spinal stenosis" or "congenital spinal stenosis" and "lumbar". Read More

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http://dx.doi.org/10.1007/s00586-020-06524-2DOI Listing

A single dose of zoledronate preserves bone mineral density for up to 2 years after a second course of romosozumab.

Osteoporos Int 2020 Jul 4. Epub 2020 Jul 4.

Amgen Inc., Thousand Oaks, CA, USA.

This phase 2 study evaluated the efficacy and safety of transitioning to zoledronate following romosozumab treatment in postmenopausal women with low bone mass. A single dose of 5 mg zoledronate generally maintained the robust BMD gains accrued with romosozumab treatment and was well tolerated.

Introduction: Follow-on therapy with an antiresorptive agent is necessary to maintain the skeletal benefits of romosozumab therapy. Read More

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http://dx.doi.org/10.1007/s00198-020-05502-0DOI Listing

Do rheumatoid arthritis patients have low back pain or radiological lumbar lesions more frequently than the healthy population? -Cross-sectional analysis in a cohort study with age and sex-matched healthy volunteers.

Spine J 2020 Jul 2. Epub 2020 Jul 2.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background Context: Rheumatoid arthritis (RA) can affect the spine; however, the epidemiology of lumbar lesions and/or low back pain (LBP) in RA patients has not been well-studied.

Purpose: The purpose of this study was to compare the prevalence of lumbar lesions and LBP in RA patients with that in healthy volunteers, and to elucidate the influence of RA on lumbar disease.

Study Design: Cross-sectional analysis in a cohort study with age- and sex-matched healthy volunteers. Read More

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http://dx.doi.org/10.1016/j.spinee.2020.06.020DOI Listing

Hand grip strength can predict clinical outcomes and risk of falls after decompression and instrumented posterolateral fusion for lumbar spinal stenosis.

Spine J 2020 Jul 2. Epub 2020 Jul 2.

Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Background Context: There has been limited research on the association between hand grip strength (HGS) as one of the diagnostic criteria for sarcopenia and surgical outcomes of lumbar spinal stenosis (LSS).

Purpose: We aimed to determine the effect of HGS on surgical outcomes and risk of fall in patients with LSS.

Study Design: This is a retrospective observational study. Read More

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http://dx.doi.org/10.1016/j.spinee.2020.06.022DOI Listing

Technical Consideration of Interlaminar Approach in the Lumbar Disc Herniation.

World Neurosurg 2020 Jul 2. Epub 2020 Jul 2.

Division of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan; School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; College of nursing and health sciences, Dayeh University, Taiwan. Electronic address:

With the evolution of endoscopic instruments and techniques, full-endoscopic spine surgery(FESS) has attracted more attention worldwide in recent years. At the initial stage, surgeons conducted endoscopic lumbar discectomy by the transforaminal approach. Then, interlaminar endoscopic lumbar discectomy(IELD) was brought in treating herniation disc at the L5-S1 level. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.211DOI Listing

Rapid progression of spinal epidural lipomatosis after percutaneous endoscopic spine surgery mimicking disc herniation.

Int J Surg Case Rep 2020 Jun 24;73:1-4. Epub 2020 Jun 24.

Department of Orthopaedic Surgery, Dongeui Medical Center, 62 Yangjung-ro, Jin-gu, Busan, 47227, South Korea. Electronic address:

Introduction: Spinal epidural lipomatosis (SEL) is well known but uncommon complication of endoscopic spine surgery. Here, we present a case of SEL that progressed focally and rapidly after endoscopic spinal surgery.

Presentation Of Case: A 67-year-old man presented with back and Lt. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334442PMC

Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study.

Arch Osteoporos 2020 Jul 3;15(1):100. Epub 2020 Jul 3.

Department of Preventive Medicine, Ajou University School of Medicine, 206 Worldcup-ro, Yeongtong-gu, Suwon, 443-721, South Korea.

The bone mineral densities (BMDs) of the femoral neck and total hip, and the lumbar spine trabecular bone score (TBS), tended to decrease with age in both men and women, whereas the lumbar spine BMD tended to increase. Lumbar spine BMD is thus inappropriate for evaluating longitudinal changes in bone loss; the lumbar spine TBS is an alternative measure.

Purpose: Aging is associated with a decrease in bone mass and quality. Read More

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http://dx.doi.org/10.1007/s11657-020-00731-6DOI Listing

Preoperative patient activation is predictive of improvements in patient-reported outcomes following minimally invasive lumbar decompression.

Eur Spine J 2020 Jul 3. Epub 2020 Jul 3.

Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. Harrison St. Suite #300, Chicago, IL, 60612, USA.

Purpose: To determine whether there is an association between preoperative 10-Item Patient Activation Measure (PAM-10) scores and clinical outcomes following MIS LD.

Methods: Patients undergoing a primary MIS LD were retrospectively reviewed and stratified according to their preoperative PAM-10 scores: "low PAM," "moderate PAM," and "high PAM." Preoperative PAM score cohorts were tested for improvements in Oswestry Disability Index (ODI), 12-Item Short-Form Physical Component Score (SF-12 PCS), and Visual Analog Scale (VAS) back and leg pain using multivariate linear regression. Read More

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http://dx.doi.org/10.1007/s00586-020-06512-6DOI Listing