Search Our Scientific Publications & Authors

J Bone Metab 2021 May 31;28(2):151-159. Epub 2021 May 31.

Department of Rheumatology, Mohammed VI University Hospital, Faculty of Medicine, Mohammed I University, Oujda, Morocco.

Background: Rheumatoid arthritis (RA) is a known cause of joint destruction and systemic bone loss. In this study, we aimed to evaluate the bone damage and bone loss profiles of established RA patients.

Methods: We designed a cross-sectional study on a cohort of established RA patients. Read More

J Bone Metab 2021 May 31;28(2):131-137. Epub 2021 May 31.

Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background: In a randomized controlled trial, we compared the bone mineral densities (BMDs) and blood markers of bone turnover during short-term treatment of osteoporotic women with bisphosphonate alendronate or bazedoxifene, a selective estrogen receptor modulator.

Methods: Ten and eleven patients were randomized to the alendronate and bazedoxifene groups, respectively. BMDs were measured before and after 6 months of treatment. Read More

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

School of Chinese medicine, Jinan university, Guangzhou, China. Electronic address:

Background: Adjacent segmental degeneration (ASD) is one of the common complications following posterior lumbar interbody fusion (PLIF). Both whole body vibration (WBV) and osteoporosis are important factors associated with the biomechanics of the lumbar spine. However, up to now, no literature has been published to investigate the effect of osteoporosis on ASD following PLIF under WBV. Read More

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Objective: This study aims to demonstrate the efficacy of salvage oblique lumbar interbody fusion (OLIF) surgery for pseudarthrosis after posterior/transforaminal lumbar interbody fusion (PLIF/TLIF).

Methods: The subjects consist of the patients with leg or back pain induced by pseudarthrosis after PLIF/TLIF. These patients underwent salvage OLIF surgeries in our institutions between Jul 2015 to Oct 2019. Read More

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

Department of Spine surgery, Pasteur II Hospital, Centre Hospitalo-Universitaire de Nice, France.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

The Center for Pain Medicine, Peking University Third Hospital, Beijing 100191, China. Electronic address:

Objective: Lumbar spinal stenosis (LSS) is a common disease in spinal surgery. At present, many related treatment methods have been reported, but their effectiveness still lacks a systematic comparison. We aimed to evaluate the clinical outcomes related to the efficacy and safety of these treatment strategies via a network meta-analysis. Read More

Acta Orthop Belg 2021 Mar;87(1):191-196

Pedicle-based dynamic stabilization (PBDS) devices such as Dynesys are promoted as an alternative and less invasive option for rigid stabilization of one and even more levels of the lumbar spine. Promising features of the Dynesys system, as well as shortcomings, became obvious in several clinical studies. Since 2012, we started using a new PBDS device as an alternative for the Dynesys, to avoid the screw loosening and the kyphosing effect. Read More

Acta Neurochir (Wien) 2021 Jun 15. Epub 2021 Jun 15.

Division of Spine, Department of Neurosurgery, Duke University Medical Center, 200 Trent Drive, Durham, NC, 27710, USA.

Background: Robotic-assisted surgery is becoming more widely applied in surgical subspecialties due to its intraoperative and postoperative advantages such as minimally invasive approach, reduced blood loss, shorter hospital stay, and decreased incidence of postoperative complications. However, robotic devices were only recently introduced in the field of spinal surgery. Specifically, percutaneous approaches involving computer-assisted image guidance are relatively new in iliac screw fixation. Read More

Prenat Diagn 2021 Jun 15. Epub 2021 Jun 15.

Shandong Provincial Hospital Affliated to Shandong First Medical University, Jinan, Shandong, 250021, China.

Objective: Before evaluating spinal pathology, it is essential to have knowledge of the normal spinal development at different gestational ages. This study aims to characterize normal spinal growth in human fetuses during the second and third trimester.

Methods: Postmortem 3. Read More

Arch Environ Occup Health 2021 Jun 15:1-18. Epub 2021 Jun 15.

Department of Mechanical Engineering, Ch. Ranbir Singh State Institute of Engineering & Technology, Jhajjar, Haryana, India.

Musculoskeletal disorders (MSDs) are the most common health issues around the globe and a major cause of disability among workers. In developing countries, most casting industries fall under Small and Medium Scale Enterprises (SMEs); SMEs lack modern equipment and often intensively rely on manual labor. As processes are mainly labor intensive, workers employed in the metal casting sector are often at risk of MSDs. Read More

Global Spine J 2021 Jun 15:21925682211022313. Epub 2021 Jun 15.

Spine Surgery Unit, Humanitas Gradenigo Hospital, Turin, Italy.

Study Design: Literature review.

Objectives: An increasing number of obese patients requires operative care for degenerative spinal disorders. The aim of this review is to analyze the available evidence regarding the role of obesity on outcomes after spine surgery. Read More

Oper Neurosurg (Hagerstown) 2021 Jun;21(Supplement_1):S69-S80

Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA.

This review of the literature will focus on the indications, surgical techniques, and outcomes for expandable transforaminal lumbar interbody fusion (TLIF), anterior lumbar interbody fusion (ALIF), and lateral lumbar interbody fusion (LLIF) operations. The expandable TLIF cage has become a workhorse for common degenerative pathology, whereas expandable ALIF cages carry the promise of greater lordotic correction while evading the diseased posterior elements. Expandable LLIF cages call upon minimally invasive techniques for a retroperitoneal, transpsoas approach to the disc space, obviating the need for an access surgeon and decreasing risk of injury to the critical neurovascular structures. Read More

Oper Neurosurg (Hagerstown) 2021 Jun;21(Supplement_1):S2-S9

Center for Spine Health, Department of Neurosurgery, Neurologic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Background: Osteobiologics are engineered materials that facilitate bone healing and have been increasingly used in spine surgery. Autologous iliac crest bone grafts have been used historically, but morbidity associated with graft harvesting has led surgeons to seek alternative solutions. Allograft bone, biomaterial scaffolds, growth factors, and stem cells have been explored as bone graft substitutes and supplements. Read More

AIDS 2021 Jun 14. Epub 2021 Jun 14.

Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Rutgers University, Piscataway, NJ, USA Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Office of Scholarship & Research, School of Nursing, Columbia University, New York, NY, USA New York Nutrition Obesity Research Center, Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA Department of Medicine, Division of Infectious Disease, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA Department of Pediatrics, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA.

Objective: We evaluated longitudinal trends and associations between bone mass, bone turnover and inflammatory markers among South African children living with HIV (CLHIV) and controls.

Design: We previously reported decreased bone mass among CLHIV independent of marked inflammation and increased bone turnover. The goal of this study was to evaluate longitudinal changes in bone mass, bone turnover and inflammation over two years. Read More

Brain Nerve 2021 Jun;73(6):715-724

Department of Neurology, Teikyo University School of Medicine.

Magnetic resonance imaging (MRI) is widely employed in the diagnosis of lumbar spine disorders, such as lumbar spinal stenosis or lumbar disc herniation. However, incomplete specificity is a definite drawback, given that MRI abnormalities are frequently identified in aged control subjects. Relying solely on MRI without considering clinical symptoms/signs or electrodiagnosis may lead to misdiagnosis. Read More

Brain Nerve 2021 Jun;73(6):671-683

Department of Neurology, Kameda Medical Center.

Currently, intermittent claudication is classified into the vascular (mainly secondary to peripheral arterial disease) and neurogenic (mainly secondary to lumbar canal stenosis) types. Intermittent claudication due to spinovascular insufficiency (myelopathy) has rarely been reported since it was first described by J. Dejerine in 1894. Read More

Trials 2021 Jun 14;22(1):398. Epub 2021 Jun 14.

Department of Spine, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, China.

Background: Degenerative lumbar instability (DLI) is a common disease that causes low back pain (LBP) in clinic. It is difficult to completely recover from DLI, and it occurs repeatedly, which seriously affects the quality of life of patients. The epidemiological survey showed that 20-30% of low back pain was related to lumbar instability. Read More

J Orthop Surg Res 2021 Jun 14;16(1):380. Epub 2021 Jun 14.

Department of Orthopedic Surgery, Spine Center, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1, Singil-ro, Yeongdeungpo-gu, Seoul, Republic of Korea, 07441.

Background: Lower lumbar osteoporotic vertebral compression fracture in extremely elderly patients can often lead to lumbosacral radiculopathy (LSR) due to delayed vertebral collapse (DVC). Surgical intervention requires posterior instrumented lumbar fusion as well as vertebral augmentation or anterior column reconstruction depending on the cleft formation and intravertebral instability. However, it is necessary to decide on surgery in consideration of the patient's frail status, surgical invasiveness, and rehabilitation. Read More

Appl Ergon 2021 Jun 11;96:103491. Epub 2021 Jun 11.

Department of Materials and Production, Aalborg University, Fibigerstræde 16, 9220 Aalborg, Denmark. Electronic address:

Musculoskeletal models may enhance our understanding of the dynamic loading of the joints during manual material handling. This study used state-of-the-art musculoskeletal models to determine the effects of load mass, asymmetry angle, horizontal location and deposit height on the dynamic loading of the knees, shoulders and lumbar spine during lifting. Recommended weight limits and lifting indices were also calculated using the NIOSH lifting equation. Read More

Clin Infect Dis 2021 Jun 14. Epub 2021 Jun 14.

Centre of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: To evaluate the impact of vitamin D and calcium supplementation(VitD/Ca) on lumbar spine bone mineral density(LSBMD) and bone metabolism among Thai adolescents with perinatally acquired HIV(PHIVA).

Methods: A multicenter, randomized, active-control, open-labeled trial was conducted. PHIVA(aged10-20years) who were on stable cART were enrolled. Read More

Orthop Surg 2021 Jun 14. Epub 2021 Jun 14.

Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Objective: Physical exercise has obvious effects on bone loss, pain relief, and improvement of bone metabolism indexes in patients with osteoporosis, but currently lacks sufficient evidence. The aim of this systematic review and meta-analysis was to synthesize and present the best available evidence on the effectiveness and safety of exercises in the treatment of primary osteoporosis.

Methods: Publications pertaining to the effectiveness of exercise on bone mineral density (BMD), visual analog scores (VAS), and biochemical markers of bone metabolism in primary osteoporosis (POP) from PubMed, Cochrane Library, Embase, VIP, CNKI, and Wanfang Database were retrieved from their inception to April 2020. Read More

Front Surg 2021 28;8:662919. Epub 2021 May 28.

Department of Industrial Engineering, Alma Mater Studiorum, Universita di Bologna, Bologna, Italy.

The number of patients with iatrogenic spinal deformities is increasing due to the increase in instrumented spinal surgeries globally. Correcting a deformity could be challenging due to the complex anatomical and geometrical irregularities caused by previous surgeries and spine degeneration. Virtual and 3D printed models have the potential to illuminate the unique and complex anatomical-geometrical problems found in these patients. Read More

Int J Sports Phys Ther 2021 Jun 1;16(3):636-650. Epub 2021 Jun 1.

ProRehab Physical Therapy.

Background And Purpose: Low back pain is one of the most common conditions occurring in the golfing population. Many approaches have been utilized throughout the years to address this condition including the concept of regional interdependence. The purpose of this case report is to describe the evaluation process and treatment approach of a golfer with low back pain using the principles of regional interdependence. Read More

Int J Sports Phys Ther 2021 Jun 1;16(3):628-635. Epub 2021 Jun 1.

Texas Woman's University.

Background: Individuals with chronic low back pain (CLBP) may demonstrate reduced ability to perform dynamic tasks due to fear of additional pain and injury in response to the movement. The Y-balance test (YBT) is a functional and inexpensive test used with various populations. However, the reliability and validity of the YBT used for assessing dynamic balance in young adults with CLBP have not yet been examined. Read More

J Pain Res 2021 4;14:1593-1600. Epub 2021 Jun 4.

Department of Spine Surgery, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.

Purpose: Percutaneous endoscopic lumbar discectomy for the treatment of far-migrated lumbar disc herniation (LDH) is clinically challenging. The aim of this study was to compare the efficacy and safety of interlaminar endoscopic lumbar discectomy (IELD) and interlaminar microscopic lumbar discectomy (IMLD) for the treatment of far-migrated LDH.

Materials And Methods: We retrospectively analyzed 50 consecutive cases of far-migrated LDH treated by IELD or IMLD. Read More

Clin Spine Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Orthopedic Surgery, Northwestern Memorial Hospital, Chicago, IL Hospital for Special Surgery, New York, NY.

Patients presenting to an outpatient spine clinic frequently report symptoms of low back pain with associated buttock, groin, and lower extremity pain. While many of these individuals suffer from lumbar spine radiculopathy, a number of different orthopedic pathologies can mimic these symptoms. Management depends substantially on a detailed history and physical examination, in addition to working from a broad list of differential diagnoses when evaluating these patients. Read More

Int Orthop 2021 Jun 13. Epub 2021 Jun 13.

Department of Spine Surgery, Qilu Hospital, Shandong University, 107, West Culture Road, Lixia District, Jinan, China.

Int J Surg Case Rep 2021 Jun 9;84:106066. Epub 2021 Jun 9.

Department of Surgery, Division of Trauma and Surgical Critical Care, Kendall Regional Medical Center, Miami, FL, USA; University of South Florida, Tampa, FL, USA.

Introduction And Importance: Low voltage electrical injuries (less than 1000 V) can produce enough tetany to cause fractures, usually of the upper extremities. Simultaneous bilateral fractures of the femoral neck are an extremely rare occurrence. It is even more uncommon for a young healthy male to suffer significant fractures from a low voltage injury. Read More

Braz J Phys Ther 2021 May 24. Epub 2021 May 24.

Antalya Training and Research Hospital, Department of Neurology, Health Sciences University, Antalya, Turkey; Antalya Training and Research Hospital, Neuromuscular Disease Center, Health Sciences University, Antalya, Turkey.

Background: Increment of lumbar lordosis, a frequent spinal finding in Duchenne Muscular Dystrophy (DMD), is a compensatory mechanism secondary to muscle weakness. However, excessive lumbar lordosis may change the position of the center of mass, and lead to balance and walking difficulties.

Objective: To study the relationship between factors that may influence ambulatory function in boys with DMD and to investigate the effects of lumbar lordosis increment on gait and balance perturbations. Read More

J Clin Neurosci 2021 Jul 27;89:8-14. Epub 2021 Apr 27.

Rehabilitation Division, Tottori University Hospital, 36-1 Nishi-cho, Yonago, Tottori 683-8504, Japan; School of Health Science, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

It remains controversial whether preoperative low muscle mass affects clinical outcomes after lumbar surgery. Previous studies evaluated outcomes such as pain, quality of life, and disability, but none investigated preoperative low muscle mass and psychological factors. The purpose of this study was to clarify the association between preoperative low muscle mass and postoperative psychological factors in lumbar spinal stenosis (LSS). Read More