74,975 results match your criteria Lumbar Spine


Comparison of long-term use of combined oral contraceptive after gonadotropin-releasing hormone agonist plus add-back therapy versus dienogest to prevent recurrence of ovarian endometrioma after surgery.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 11;236:53-57. Epub 2019 Mar 11.

Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Objective: The aim of this study was to compare long-term use of combined oral contraceptive (COC) after gonadotropin-releasing hormone (GnRH) agonist plus add-back therapy with dienogest (DNG) treatment as medical treatments after surgery for ovarian endometrioma.

Methods: This prospective cohort study analyzed 52 reproductive-aged women who underwent surgery for ovarian endometrioma and received postoperative medical treatment with either COC after GnRH agonist (n = 20) or DNG (n = 32) for 24 months. Changes in quality-of-life (QOL) and bone mineral density (BMD) were compared according to treatment. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.02.032DOI Listing

Dependence of lumbar loads on spinopelvic sagittal alignment: An evaluation based on musculoskeletal modeling.

PLoS One 2019 18;14(3):e0207997. Epub 2019 Mar 18.

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Still little is known about how spinopelvic alignment affects spinal load distribution. Musculoskeletal modeling can potentially help to discover associations between spine alignment and risk factors of spinal disorders (e.g. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207997PLOS

Motor and Sensory Impairments of the Lower Extremities After L2 Nerve Root Transection During Total en Bloc Spondylectomy.

Spine (Phila Pa 1976) 2019 Mar 4. Epub 2019 Mar 4.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

MINI: An initial weakness of the iliopsoas and quadriceps femoris muscles was observed in the majority of patients who underwent bilateral transection of L2 nerve roots during total en bloc spondylectomy for spinal tumor involving L2. However, these deficits recovered over time and did not finally affect activities of daily living.

Study Design: Retrospective study OBJECTIVE. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003032DOI Listing

Clinical Level of Evidence Presented at the Lumbar Spine Research Society (LSRS) Annual Meeting Over 10 Years (2008-2017): A Systematic Review.

Spine (Phila Pa 1976) 2019 Mar 4. Epub 2019 Mar 4.

Department of Orthopaedic Surgery Spine Service, Michigan Medicine, Ann Arbor, MI.

Study Design: Systematic Review OBJECTIVE.: The Lumbar Spine Research Society (LSRS) is dedicated to advancing knowledge of the lumbar spine to promote evidence-based care. We sought to systematically review the level of clinical evidence presented at LSRS annual meetings from 2008 through 2017. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003029DOI Listing

Endoscopic spinal surgery using a new tubular retractor with 15 mm outer diameter.

Br J Neurosurg 2019 Mar 18:1-8. Epub 2019 Mar 18.

a Department of Neurosurgery , Saarland University Medical Center and Saarland University Faculty of Medicine , Homburg/Saar , Germany.

Purpose: To assess whether the instrument handling and image quality of endoscopic spinal decompression procedures is adequate and effects the treatment of degenerative spinal disorders.

Material And Methods: Forty-six patients underwent endoscopic procedures for radicular pain or sensorimotor deficit due to a degenerative disorder using a 15mm tubular retractor. Endoscopic video recordings were reviewed with focus on instrument handling and intraoperative complication. Read More

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http://dx.doi.org/10.1080/02688697.2019.1584269DOI Listing

Bone Mineral Density, TBS, and Body Composition Indexes in Ukrainian Men with Parkinson's Disease.

Parkinsons Dis 2019 7;2019:9394514. Epub 2019 Feb 7.

SI "D. F. Chebotarev Institute of Gerontology NAMS of Ukraine", Department of Clinical Physiology & Pathology of Extrapiramide Nervous System, Kyiv, Ukraine.

Introduction: Current research studies demonstrate the changes of bone mineral density (BMD) in subjects with Parkinson's disease (PD); however, data about bone quality and body composition (BC) indexes are insufficient. The aim of the study was to assess the parameters of BMD, ВС, and trabecular bone score (TBS) in PD males.

Materials And Methods: We performed a cross-sectional case-control research design and examined 76 males aged 50-77 years old, who were divided into two groups: first group including men without PD (=38) and the second group including subjects with PD (=38). Read More

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http://dx.doi.org/10.1155/2019/9394514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383390PMC
February 2019

Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study.

Int J Endocrinol 2019 6;2019:9802827. Epub 2019 Feb 6.

CNR-Regione Toscana G Monasterio Foundation, Pisa, Italy.

Purpose: Oral bisphosphonates (BPs) are the most commonly used medications for osteoporosis (OP), but their poor gastrointestinal (GI) absorption and tolerance hamper compliance. Intramuscular (IM) neridronate (NE), an amino-BP, is an easy-to-administer, effective, and safe alternative to oral BPs. We assessed the 6-year effects of monthly IM NE on bone mineral density (BMD) and bone turnover biomarkers (BMs) in postmenopausal OP. Read More

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http://dx.doi.org/10.1155/2019/9802827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381585PMC
February 2019

Reduction of direct costs in high-risk lumbar discectomy patients during the 90-day post-operative period through annular closure.

Clinicoecon Outcomes Res 2019 28;11:191-197. Epub 2019 Feb 28.

Sierra Neuroscience Institute, Los Angeles, CA, USA,

Purpose: Despite being an extremely successful procedure, recurrent disc herniation is one of the most common post-discectomy complications in the lumbar spine and contributes significant health care and socioeconomic costs. Patients with large annular defects are at a high risk for reherniation, but an annular closure device (ACD) has been designed to reduce reherniation risk in this population and may, in turn, help control direct health care costs after discectomy.

Patients And Methods: This analysis examined the 90-day post-discectomy cost estimates among ACD-treated (n=272) and control (discectomy alone; n=278) patients in a randomized controlled trial (RCT). Read More

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http://dx.doi.org/10.2147/CEOR.S193603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400234PMC
February 2019

Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years.

Clin Interv Aging 2019 25;14:445-451. Epub 2019 Feb 25.

Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian District, Beijing 100853, China,

Aim: The aim of this study was to determine the relationship between abnormal glucose metabolism and osteoporosis (OP) in Han Chinese men over the age of 50 years.

Patients And Methods: A cross-sectional study of 775 male patients aged over 50 years was performed at our hospital in 2011. The patients were divided into a normal glucose metabolism group, an impaired glucose regulation (IGR) group, and a type 2 diabetes mellitus (T2DM) group. Read More

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http://dx.doi.org/10.2147/CIA.S164021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394237PMC
February 2019

Hybrid of Compressed Sensing and Parallel Imaging Applied to Three-dimensional Isotropic T-weighted Turbo Spin-echo MR Imaging of the Lumbar Spine.

Magn Reson Med Sci 2019 Mar 15. Epub 2019 Mar 15.

Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University.

Purpose: The hybrid compressed sensing (hybrid-CS) technique can shorten the acquisition time compared with the sensitivity encoding (SENSE) technique in lumbar MRI. To evaluate the feasibility of a hybrid-CS technique in comparison with 3D isotropic T-weighted turbo spin-echo (3D volume isotropic turbo spin-echo acquisition [VISTA]) MRI of the lumbar spine.

Materials And Methods: The Institutional Review Board approved this study and informed consent was obtained from participants prior to study entry. Read More

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http://dx.doi.org/10.2463/mrms.mp.2018-0132DOI Listing

Finite element method-based study of pedicle screw-bone connection in pullout test and physiological spinal loads.

Med Eng Phys 2019 Mar 14. Epub 2019 Mar 14.

Texas Back Institute, Plano, TX, USA.

Finite element (FE) method has been widely used to study the screw-bone connections. Screw threads are often excluded from the FE spine model to reduce computational cost. However, no study has been conducted to compare the effect of such simplification in the screw models on the predicting accuracy of the model. Read More

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http://dx.doi.org/10.1016/j.medengphy.2019.03.004DOI Listing

Prediction of brace effect in scoliotic patients: blinded evaluation of a novel brace simulator-an observational cross-sectional study.

Eur Spine J 2019 Mar 16. Epub 2019 Mar 16.

Anatoscope-Cap-Omega Rond-Point Benjamin Franklin, 34960, Montpellier, France.

Purpose: Bracing is the most commonly used treatment for scoliosis. But braces remain predominantly "handcrafted." Our objective was to create a novel brace simulator using a high-fidelity 3D "avatar" of the patient's trunk. Read More

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http://dx.doi.org/10.1007/s00586-019-05948-9DOI Listing

Evaluation of Postoperative Spinal Epidural Eematoma after Bi portal Endoscopic Spine Surgery (BESS) for Single Level Lumbar Spinal Stenosis : Clinical and Magnetic Resonance Image Study.

World Neurosurg 2019 Mar 13. Epub 2019 Mar 13.

Department of Orthopaedic Surgery, Chungnam National University School of Medicine, Daejeon, Republic of Korea.

Background: Symptomatic postoperative spinal epidural hematoma is a serious complication that may occur after lumbar spine surgery. Authors analyzed epidural hematoma using postoperative MRI after biportal endoscopic spinal surgery and the impact of which to the clinical outcome.

Methods: The subject of this study were 158 patients who underwent single-level decompression using the biportal endoscopic spinal surgery technique from 2015 to 2017. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.150DOI Listing

Functional characterization of the C7ORF76 genomic region, a prominent GWAS signal for osteoporosis in 7q21.3.

Bone 2019 Mar 13. Epub 2019 Mar 13.

Department of Genetics, Microbiology and Statistics, Facultat de Biologia, Universitat de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, IBUB, IRSJD, Barcelona, Catalonia, Spain. Electronic address:

Genome-wide association studies (GWAS) have repeatedly identified genetic variants associated with bone mineral density (BMD) and osteoporotic fracture in non-coding regions of C7ORF76, a poorly studied gene of unknown function. The aim of the present study was to elucidate the causality and molecular mechanisms underlying the association. We re-sequenced the genomic region in two extreme BMD groups from the BARCOS cohort of postmenopausal women to search for functionally relevant variants. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.014DOI Listing

Preoperative assessment of idiopathic scoliosis in adolescent and young adult with three-dimensional T2-weighted spin-echo MRI.

Diagn Interv Imaging 2019 Mar 13. Epub 2019 Mar 13.

Lille Catholic Hospitals, Imaging Department, 59000 Lille, France; Lille Catholic University, 59000 Lille, France; PMOI Physiopathology of Inflammatory Bone Diseases, EA 4490, 59000 Lille, France. Electronic address:

Purpose: To compare tridimensional (3D) T2-weighted spin-echo MRI and CT for minimal pedicle width measurements in the preoperative assessment of adolescent idiopathic scoliosis (AIS) in adolescent and young patients.

Materials And Methods: A total of 22 adolescents/young patients suffering from AIS were retrospectively included. There were 18 females and 4 males with a mean age of 15. Read More

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http://dx.doi.org/10.1016/j.diii.2019.01.010DOI Listing

X-ray examination dose surveys: how accurate are my results?

Eur Radiol 2019 Mar 15. Epub 2019 Mar 15.

Department of Radiology, EPICURA, Clinique Louis Caty, Rue Louis Caty 136, 7331, Baudour, Belgium.

Objectives: To determine the variabilities of dose-area-products (DAP) of frequent X-ray examinations collected for comparison with diagnostic reference levels (DRLs).

Methods: DAP values of chest, abdomen, and lumbar spine examinations obtained on devices from two manufacturers were collected in three centers over 1 to 2 years. The variability of the average DAP results defined as the 95% confidence interval in percentage of their median value was calculated for increasing sample sizes, each examination and center. Read More

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http://dx.doi.org/10.1007/s00330-019-06055-5DOI Listing

Back pain and sagittal spine alignment in obese patients eligible for bariatric surgery.

Eur Spine J 2019 Mar 15. Epub 2019 Mar 15.

Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Objective: The objective of this research was to evaluate the prevalence of cervical and lumbar pain in obese patients eligible for bariatric surgery and to investigate possible changes in sagittal spine alignment in these patients.

Methods: The following parameters were compared in 30 obese patients and a control group of 25 non-obese volunteers: body mass index, prevalence of cervical and lumbar pain assessed by visual analog scale (VAS), Neck Disability Index [NDI] and Oswestry Disability Index [ODI], as well as radiographic parameters of the spine and pelvis measured with Surgimap software.

Results: The cervical and lumbar VAS and the NDI and ODI were significantly worse in obese patients. Read More

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http://dx.doi.org/10.1007/s00586-019-05935-0DOI Listing

Ossification of the Ligamentum Flavum at the Thoracic and Lumbar Region in an Achondroplastic Patient: A Case report.

World Neurosurg 2019 Mar 12. Epub 2019 Mar 12.

Cagatay Ozturk: Istinye University Medical Faculty, Orthopedics and Traumatology Department, Istanbul, Turkey.

Background: Achondroplasia, a genetic disorder of bone growth, produces specific clinical features of the extremities and spine. Spinal stenosis, seen in patients with achondroplasia, is a congenital disorder related to premature fusion of the pedicles to the lamina. It can be caused by ossification of the ligamentum flavum, which is rare in patients with achondroplasia. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.028DOI Listing

Braking reaction time before and after surgery for patients with recurrent lumbar disc herniation.

J Neurosurg Spine 2019 Mar 15:1-5. Epub 2019 Mar 15.

Departments of1Orthopaedic Surgery.

OBJECTIVEThe positive effect of primary lumbar disc surgery on braking reaction time (BRT) has already been shown. The authors investigated the effect of recurrent lumbar disc herniation surgery on BRT.METHODSTwenty-four patients (mean age 49. Read More

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http://dx.doi.org/10.3171/2019.1.SPINE18859DOI Listing

Does relocation of the apex after osteotomy affect surgical and clinical outcomes in patients with ankylosing spondylitis and thoracolumbar kyphosis?

J Neurosurg Spine 2019 Mar 15:1-8. Epub 2019 Mar 15.

OBJECTIVERelocation of the apex is often found in patients with ankylosing spondylitis (AS)-associated thoracolumbar/lumbar kyphosis after corrective surgery. This study evaluates the influence of different postoperative apex locations on surgical and clinical outcomes of osteotomy for patients with AS and thoracolumbar kyphosis.METHODSSixty-two patients with a mean age of 34. Read More

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http://dx.doi.org/10.3171/2018.12.SPINE18752DOI Listing

A pilot study of influence of pedicle screw instrumentation on immature vertebra: a minimal 5-year follow-up in children younger than 5 years.

J Neurosurg Pediatr 2019 Mar 15:1-8. Epub 2019 Mar 15.

1Department of Orthopedics of Peking Union Medical College Hospital, Beijing.

OBJECTIVEConcerns remain over the influence of pedicle screw instrumentation on the growth potential of an immature spine. Previous studies have reported discrepancies between animal experiments and clinical studies. The authors' objective was to explore the influence of pedicle screw instrumentation on the growth of an immature spine at a very young age. Read More

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http://dx.doi.org/10.3171/2018.12.PEDS18622DOI Listing

Influence of diabetes mellitus on patients with lumbar spinal stenosis: A nationwide population-based study.

PLoS One 2019 15;14(3):e0213858. Epub 2019 Mar 15.

Department of Neurosurgery, Keimyung University Dongsan Medical Center, Daegu, Korea.

Purpose: To evaluate the relationship between comorbidities, medical cost, and surgical outcome in patients with lumbar spinal stenosis (LSS) and diabetes mellitus (DM).

Methods: Data on patients with LSS (n = 14,298) were collected from the Korean National Health Insurance Service database from 2005 to 2007. After 8 years of follow-up, a "DM group" (n = 3,478) and a "non-DM group" (n = 10,820) were compared according to outcome measures. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213858PLOS

[Functional state of spinal cord and its radices in patients with thoracic and lumbar spine injuries].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(2):44-48

Research Institute of Traumatology, Orthopedics and Neurosurgery 'Razumovsky Saratov State Medical University' of Ministry Health of the Russian Federation, Saratov, Russia.

Aim: To estimate the character of neurophysiological monitoring in patients with thoracic and lumbar spine injuries at different treatment stages.

Material And Methods: Thirty-eight patients with non-complicated (22 patients, group 1) and complicated (16 patients, group 2) thoracic and lumbar spine injuries underwent electroneuromyography (ENM) and transcranial magnetic stimulation (TMS). The examination was performed at early (up to 2 weeks) and later (more than 1 month) post-injury periods, before the operation and on the 10 day after decompressing-stabilizing interventions. Read More

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http://dx.doi.org/10.17116/jnevro201911902144DOI Listing
January 2019
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[Effectiveness of nano-hydroxyapatite/polyamide-66 Cage in interbody fusion for degenerative lumbar scoliosis].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Mar;33(3):287-295

Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R.China.

Objective: To explore the effectiveness of nano-hydroxyapatite/polyamide-66 (n-HA/PA66) Cage in interbody fusion for degenerative lumbar scoliosis.

Methods: A retrospective analysis was designed and conducted for 43 patients, who underwent posterior decompression and n-HA/PA66 Cage interbody fusion with correction of deformity between January 2013 and June 2016. Eighteen cases were single-level fusion (single-level group) and 25 cases were double-level fusion (double-level group). Read More

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http://dx.doi.org/10.7507/1002-1892.201807060DOI Listing
March 2019
1 Read

[Effect of anterior cervical discectomy and decompression with different fusion segments on sagittal spine-pelvis balance].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Mar;33(3):265-272

Department of Spinal Surgery, Shanghai Oriental Hospital Affiliated to Tongji University, Shanghai, 200120,

Objective: To explore the effect on sagittal spine-pelvis balance of different fusion segments in anterior cervical discectomy and fusion (ACDF).

Methods: The clinical data of 326 patients with cervical spondylotic myelopathy, treated by ACDF between January 2010 and December 2016, was retrospectively analysed. There were 175 males and 151 females with an average age of 56 years (range, 34-81 years). Read More

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http://dx.doi.org/10.7507/1002-1892.201807077DOI Listing

Analysis of treatment cost variation among multiple neurosurgical procedures using the Value-Driven Outcomes database.

World Neurosurg 2019 Mar 11. Epub 2019 Mar 11.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah. Electronic address:

Background: Healthcare costs comprise a substantial portion of total national expenditure. Although cost-effectiveness analysis in neurosurgery has recently become popular, there has been little cross-comparison of neurosurgical procedures. Our objective was to compare costs across elective neurosurgical procedures to understand whether drivers of cost differ. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.010DOI Listing

The rate of fusion for stand-alone anterior lumbar interbody fusion: a systematic review.

Spine J 2019 Mar 11. Epub 2019 Mar 11.

Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021. Electronic address:

Background: Anterior lumbar interbody fusion (ALIF) has been used for treatment of a variety of spinal conditions including degenerative disc disorders and low-grade spondylolisthesis. Expected fusion rate of stand-alone ALIF constructs is currently unclear. The aim of this study was to examine the fusion rate for anterior lumbar interbody fusion without supplemental posterior fusion or instrumentation (stand-alone ALIF). Read More

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http://dx.doi.org/10.1016/j.spinee.2019.03.001DOI Listing

The fate of thoracolumbar surgeries in patients with Parkinson's disease, and analysis of risk factors for revision surgeries.

BMC Musculoskelet Disord 2019 Mar 14;20(1):106. Epub 2019 Mar 14.

Department of Orthopedics Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital, Chang Gung University, No._5, Fu-Shin Street, Kweishian, Taoyuan, 333, Taiwan.

Background: Compared to patients without Parkinson's disease (PD), patients with PD who underwent spinal surgeries were reported to have a relatively high complication rate. However, studies that analyze surgical risk factors for these patients are limited.

Methods: From October 2004 to April 2015, patients with PD who underwent spinal surgeries at our department were reviewed. Read More

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http://dx.doi.org/10.1186/s12891-019-2481-8DOI Listing

Retrospective analysis of accuracy and positive predictive value of preoperative lumbar MRI grading after successful outcome following outpatient endoscopic decompression for lumbar foraminal and lateral recess stenosis.

Clin Neurol Neurosurg 2019 Apr 25;179:74-80. Epub 2019 Feb 25.

Center For Advanced Spine Care of Southern Arizona, Surgical Institute of Tucson, United States; Departmemt of Orthopaedics, Fundación Universitaria Sanitas, Bogotá, D.C., Colombia; Department of Neurosurgery in the Video-Endoscopic Postgraduate Program at the, Universidade Federal do Estado do Rio de Janeiro - UNIRIO, Brazil; American Board of Orthopaedic Surgery (ABOS), United States; American Board of Spinal Surgery (ABSS), United States; American Academy of Orthopaedic Surgeons (AAOS), United States; North American Spine Society (NASS), United States; Sociedad Interamericana de Cirugía de Columna Mínimamente Invasiva (SICCMI), United States; International Intradiscal Therapy Society (IITS), United States; World Congress Minimally Invasive Spine Surgery and Techniques (WCMISST), United States. Electronic address:

Objectives: The aim of this study was to analyze the accuracy and positive predictive value (PPV) of preoperative lumbar MRI grading for successful outcome after outpatient endoscopic decompression for lumbar foraminal and lateral recess stenosis. Lumbar MRI is commonly employed in preoperative decision making to identify symptomatic pain generators amenable to surgical decompression. However, its accuracy and positive predictive value for successful postoperative pain relief after endoscopic transforaminal decompression for sciatica-type back and leg pain has not been reported. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.019DOI Listing

Effects of intravenous zoledronate on bone turnover and bone density persist for at least 11 years in HIV-infected men.

J Bone Miner Res 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine, University of Auckland, Auckland, New Zealand.

Previously we reported the results of a four-year extension of a two-year randomised placebo-controlled trial showing that the anti-resorptive effects of two annual 4mg doses of zoledronate in HIV-infected men persisted for at least five years after the second dose. We set out to determine whether the effects on bone mineral density (BMD) and bone turnover persist beyond ten years. We invited all participants in the original trial known to be alive and living in New Zealand to attend a further visit approximately 12 years after trial entry and 11 years after their second dose of study medication. Read More

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http://dx.doi.org/10.1002/jbmr.3712DOI Listing

Hematological Effects of Non-Homogenous Ionizing Radiation Exposure in a Non-Human Primate Model.

Radiat Res 2019 Mar 14. Epub 2019 Mar 14.

a   Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland 21201.

Detonation of a radiological or nuclear device in a major urban area will result in heterogenous radiation exposure, given to the significant shielding of the exposed population due to surrounding structures. Development of biodosimetry assays for triage and treatment requires knowledge of the radiation dose-volume effect for the bone marrow (BM). This proof-of-concept study was designed to quantify BM damage in the non-human primate (NHP) after exposure to one of four radiation patterns likely to occur in a radiological/nuclear attack with varying levels of BM sparing. Read More

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http://www.rrjournal.org/doi/10.1667/RR15280.1
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http://dx.doi.org/10.1667/RR15280.1DOI Listing
March 2019
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Bone Metabolism Markers in Thalassemia Major-Induced Osteoporosis: Results from a Cross-Sectional Observational Study.

Curr Mol Med 2019 Mar 13. Epub 2019 Mar 13.

Hematology/Oncology Unit, First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon & Levadeias, 11527, Goudi, Athens. Greece.

Background: Thalassemia major (TM) patients eventually face many new health conditions, including endocrinopathies and low bone mineral density, usually observed in the aging general population.

Objective: The aim of the current study was to evaluate biomarkers of bone remodeling in TM patients and to compare them with both osteoporotic and healthy population, in order to investigate new therapeutic paths.

Method: Sixty-four patients with TM (32 men and 32 women) participated in the study. Read More

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http://dx.doi.org/10.2174/1566524019666190314114447DOI Listing
March 2019
1 Read

Vertebral osteomyelitis due to Candida species.

Infection 2019 Mar 13. Epub 2019 Mar 13.

Department of Pathology and Laboratory Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, USA.

Objective: We have noted an increased number of cases of vertebral osteomyelitis secondary to Candida species over the past few years at our facility. Our aim was to identify and review these cases to elucidate risk factors, treatment regimens and outcomes.

Methods: We performed a retrospective chart review using our electronic medical record and microbiology laboratory database to identify cases of vertebral osteomyelitis due to Candida at a single teaching hospital from 2006-2018. Read More

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http://dx.doi.org/10.1007/s15010-019-01294-6DOI Listing

Stages of sarcopenia, bone mineral density, and the prevalence of osteoporosis in older women.

Arch Osteoporos 2019 Mar 13;14(1):38. Epub 2019 Mar 13.

Faculty of Physical Education, University of Brasília, Asa Norte, Brasilia, Distrito Federal, 70910-900, Brazil.

A better understanding of the relationship between osteoporosis and sarcopenia may help to develop effective preventive and therapeutic strategies. In the present study, the association between different stages of sarcopenia, BMD, and osteoporosis was examined. The salient findings indicate that a dose-response relationship exists between sarcopenia stages and bone-related phenotypes. Read More

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http://link.springer.com/10.1007/s11657-019-0591-4
Publisher Site
http://dx.doi.org/10.1007/s11657-019-0591-4DOI Listing
March 2019
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Back pain following instillations of BCG for superficial bladder cancer is not a reactive complication: review of 30 Mycobacterium bovis BCG vertebral osteomyelitis cases.

Clin Rheumatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Rheumatology, Centre Hospitalier Universitaire de Rennes, 35000, Rennes, France.

Mycobacterium bovis Bacillus Calmette-Guérin (BCG) instillations are used in bladder cancer treatment. Adverse effects can occur. Osteoarticular complications are mainly reactive arthritis, but true infections have been described, such as vertebral osteomyelitis. Read More

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http://dx.doi.org/10.1007/s10067-019-04500-wDOI Listing
March 2019
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The Effect of TNF Inhibition on Bone Density and Fracture Risk and of IL17 Inhibition on Radiographic Progression and Bone Density in Patients with Axial Spondyloarthritis: a Systematic Literature Review.

Curr Rheumatol Rep 2019 Mar 12;21(5):20. Epub 2019 Mar 12.

Department of Rheumatology, Hospital for Special Surgery Hospital for Special Surgery, Weill- Cornell Medical School, 535 East 70th Street, New York, NY, 10021, USA.

Purpose Of Review: Osteoporosis in axial spondyloarthritis may be modified by therapy. The purpose of this systematic review is to describe (i) the effect of TNFi on BMD, (ii) the effect of secukinumab on BMD, and (iii) the effect of secukinumab on radiographic disease progression in axSpA.

Recent Findings: We searched PubMed, Embase, and Cochrane using the following retrieval languages: spondyloarthritis, ankylosing spondylitis, TNF, IL-17, x-rays, and osteoporosis. Read More

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http://dx.doi.org/10.1007/s11926-019-0818-9DOI Listing

Predictive factors for the efficacy of denosumab in postmenopausal Japanese women with non-metastatic breast cancer receiving adjuvant aromatase inhibitors: a combined analysis of two prospective clinical trials.

J Bone Miner Metab 2019 Mar 13. Epub 2019 Mar 13.

Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Aromatase inhibitors (AIs) are the gold standard therapy for breast cancer in postmenopausal women. AI suppresses the conversion of androgens to estrogens; however, this results in osteopenia, osteoporosis, and bone fracture, thus reducing the patient's quality of life. The use of adjuvant denosumab reduces the risk of clinical fractures in postmenopausal patients with breast cancer receiving AI. Read More

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http://dx.doi.org/10.1007/s00774-018-00985-8DOI Listing

Pyogenic Vertebral Column Osteomyelitis in Adults: Analysis of Risk Factors for 30-Day and 1-Year Mortality in a Single Center Cohort Study.

Asian Spine J 2019 Mar 15. Epub 2019 Mar 15.

Department of Orthopaedic Surgery, Waikato Hospital, Hamilton, New Zealand.

Study Design: Retrospective cohort study.

Purpose: To describe our experience in the management and outcomes of vertebral column osteomyelitis (VCO), particularly focusing on the risk factors of early and late mortality.

Overview Of Literature: Previous reports suggest a global increase in spinal column infections highlighting significant morbidity and mortality. Read More

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http://dx.doi.org/10.31616/asj.2018.0295DOI Listing

Unplanned Second-Stage Decompression for Neurological Deterioration Caused by Central Canal Stenosis after Indirect Lumbar Decompression Surgery.

Asian Spine J 2019 Mar 15. Epub 2019 Mar 15.

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Study Design: Prospective cohort study.

Purpose: This study aimed to identify risk factors for unplanned second-stage decompression for postoperative neurological deficit after indirect decompression using lateral lumbar interbody fusion (LLIF) with posterior fixation.

Overview Of Literature: Indirect lumbar decompression with LLIF has been used as a minimally invasive alternative to direct decompression to treat degenerative lumbar diseases requiring neural decompression. Read More

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http://dx.doi.org/10.31616/asj.2018.0232DOI Listing
March 2019
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Prospective Evaluation of Radiculitis following Bone Morphogenetic Protein-2 Use for Transforaminal Interbody Arthrodesis in Spine Surgery.

Asian Spine J 2019 Mar 15. Epub 2019 Mar 15.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.

Study Design: Prospective observational cohort study.

Purpose: This study aims to evaluate the safety and efficacy of bone morphogenetic protein-2 (BMP-2) in transforaminal lumbar interbody fusion (TLIF) with regard to postoperative radiculitis.

Overview Of Literature: Bone morphogenetic protein (BMP) is being used increasingly as an alternative to iliac crest autograft in spinal arthrodesis. Read More

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http://dx.doi.org/10.31616/asj.2018.0277DOI Listing
March 2019
2 Reads

Clinical and Radiographic Evaluation of Multilevel Lateral Lumbar Interbody Fusion in Adult Degenerative Scoliosis.

Clin Spine Surg 2019 Mar 8. Epub 2019 Mar 8.

Department of Orthopaedic Surgery, UConn Musculoskeletal Institute, University of Connecticut School of Medicine, Farmington, CT.

Study Design: Retrospective review of prospective data.

Objective: The objective of this study was to describe the clinical, radiographic, and complication-related outcomes through ≥1-year of 27 patients who underwent lateral lumbar interbody fusion (LLIF) with posterior instrumentation to treat ≥3 contiguous levels of degenerative lumbar scoliosis.

Summary Of Background Data: Multilevel disease has traditionally been treated with open posterior fusion. Read More

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http://dx.doi.org/10.1097/BSD.0000000000000812DOI Listing

A pilot cohort study of lumbar facet joint denervation in patients with chronic low-back pain.

Dan Med J 2019 Mar;66(3)

Introduction: Radio-frequency (RF) denervation of the facet joints is a procedure aimed at the nociceptive median branch nerves of the lumbar dorsal rami. Pain signals from the facet joints are carried through these fibres; by ablating these fibres, central signalling can be prevented. This pilot study investigated the clinical effect and feasibility of the procedure at our institution, the Spine Centre of Southern Denmark. Read More

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A Novel Mobile Phone Text Messaging Platform Improves Collection of Patient-Reported Post-operative Pain and Opioid Use Following Orthopedic Surgery.

HSS J 2019 Feb 22;15(1):37-41. Epub 2018 Oct 22.

Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021 USA.

Background: Prospective collection of patient-reported opioid consumption and pain levels post-surgically may hold value in highlighting solutions related to the opioid crisis. Traditional methods for collecting patient-reported outcomes after surgery, such as paper surveys, often have poor response rates, and electronic messaging may offer more convenience and therefore yield more robust data.

Questions/purposes: The purpose of this study was to evaluate whether a novel mobile phone short message service (SMS) platform would lead to better patient response rates to surveys on pain and opioid use than data-collection tools. Read More

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http://dx.doi.org/10.1007/s11420-018-9635-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384206PMC
February 2019
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Relationship between bone mineral density and the risk of breast cancer: a systematic review and dose-response meta-analysis of ten cohort studies.

Cancer Manag Res 2019 13;11:1453-1464. Epub 2019 Feb 13.

Department of Health Policy and Management, School of Public Health, China Medical University, Shenyang, China,

Purpose: The evidence from recent epidemiological studies investigating the relationship between bone mineral density (BMD) and the risk of breast cancer (BC) remains inconsistent.

Materials And Methods: The PubMed, EMBASE, and Web of Science databases were comprehensively searched by two independent authors to identify related cohort studies from the inception of the databases through January 31, 2018. Similarly, two researchers separately extracted the data from the selected studies, and any differences were resolved by discussion. Read More

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http://dx.doi.org/10.2147/CMAR.S188251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388999PMC
February 2019

Trends of surgical treatment for spinal degenerative disease in China: a cohort of 37,897 inpatients from 2003 to 2016.

Clin Interv Aging 2019 15;14:361-366. Epub 2019 Feb 15.

Department of Orthopaedics, Peking University Third Hospital, Beijing, China,

Purpose: Given the aging Chinese population and the inevitable degenerative process of the spine, more elderly patients with spinal degenerative disease (SDD) are surgical candidates, placing a significant burden on health care resources. Few studies have investigated recent trends in hospital admissions and procedures for SDD in China. This study aimed to identify the trends, if any, in the number of surgical procedures undertaken for SDD in a large patient cohort. Read More

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http://dx.doi.org/10.2147/CIA.S191449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388778PMC
February 2019
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Anatomical study of superior cluneal nerves: Revisiting the contribution of the lumbar spinal nerves.

World Neurosurg 2019 Mar 9. Epub 2019 Mar 9.

Seattle Science Foundation, Seattle, WA, USA; Department of Anatomical Sciences, St. George's University, Grenada, West Indies.

Objective: Superior cluneal nerve entrapment neuropathy might cause "pseudosciatica" with various symptoms. We performed cadaveric dissection of the SCN to reveal the anatomy of the SCN including its segmental origin.

Methods: Twenty sides from ten (six females and four males) Caucasian fresh frozen cadavers were used in this study. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.159DOI Listing

Re-assessment system and staged surgical strategy with minimally invasive techniques for treatment of severe adult spinal deformities.

World Neurosurg 2019 Mar 9. Epub 2019 Mar 9.

Department of Orthopedics Surgery, 2(nd) Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, People's Republic of China. Electronic address:

Objective: To determine the feasibility of minimally invasive surgery (MIS) for severe adult spinal deformities and propose a re-assessment system and minimally invasive staged surgical strategy.

Methods: We operated on 53 patients from June 2016 to August 2017 using a re-assessment system and a staged surgical strategy with minimally invasive techniques in minimally invasive spinal deformity surgery (MISDEF) class III; patients with scoliotic apex vertebrae above L1-2 or spontaneous fusion of the facet joints were excluded. The re-assessment system was applied. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.001DOI Listing

[Evidence-based guideline for the management of acute thoracolumbar injury].

Authors:

Zhonghua Wai Ke Za Zhi 2019 Mar;57(3):161-165

In order to provide the clinical guidelines of acute thoracolumbar injury for the Chinese orthopedic surgeons, the Spine Trauma Group of Chinese Association of Orthopedic Surgeons compiled this guideline. The guideline applies to adult patients with acute (less than 3 weeks) thoracolumbar fracture and(or) dislocation with or without spinal cord, cauda equina or nerve root injuries. The Study Group wrote the guideline by setting up questions, determining search words, screening literatures according to inclusion and exclusion criteria, analyzing the included literatures, confirming evidence levels and then providing recommendations. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.03.001DOI Listing

Trabecular Bone Score, Bone Mineral Density and Bone Markers in Patients with Primary Hyperparathyroidism 2 Years After Parathyroidectomy.

Horm Metab Res 2019 Mar 12;51(3):186-190. Epub 2019 Mar 12.

Endocrinology and Nutrition Department, 12 de Octubre University Hospital, Madrid, Spain.

Following a parathyroidectomy there is a bone mineral density (BMD) improvement in patients with primary hyperparathyroidism. However, data of bone microarchitecture are scarce. Trabecular bone score (TBS) estimates bone microarchitecture and could provide valuable information in those patients. Read More

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http://dx.doi.org/10.1055/a-0850-8679DOI Listing