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Clin Nucl Med 2022 Jul 1. Epub 2022 Jul 1.

From the Department of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, Haryana, India.

Purpose: Differentiating infection and sterile inflammation is the main clinical concern of clinicians as they are closely related to each other. Although 18F-FDG PET/CT imaging is widely used, its main disadvantage is its lack of specificity to discriminate aseptic from septic inflammation. 18F-WBC PET/CT scan is a promising tool for the accurate diagnosis of infection owing to its high specificity. Read More

PLoS One 2022 1;17(7):e0269694. Epub 2022 Jul 1.

School of Medicine, Keele University, Staffordshire, United Kingdom.

Background: The STarT-MSK-Tool is an adaptation of the well established STarT-Back-Tool, used to risk-stratify patients with a wider range of musculoskeletal presentations.

Objective: To formally translate and cross-culturally adapt the Keele STarT-MSK risk stratification tool into German (STarT-MSKG) and to establish its reliability and validity.

Methods: A formal, multi-step, forward and backward translation approach was used. Read More

Med Biol Eng Comput 2022 Jul 1. Epub 2022 Jul 1.

Faculty of Health and Social Sciences, Bournemouth University, Bournemouth, Dorset, UK.

Passive spinal stiffness is an important property thought to play a significant role in controlling spinal position and movement. Measuring through-range passive stiffness in vivo is challenging with several methods offered in the literature. Currently, no synthesis of values or methods exists to which to compare literature to. Read More

Eur Spine J 2022 Jul 1. Epub 2022 Jul 1.

Department of Orthopaedics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Nagoya-shi, Aichi, 466-8550, Japan.

Purpose: To clarify the impact of restriction of hip extension on radiographic whole-body sagittal alignment with using postoperative changes of radiographical parameters for hip osteoarthritis.

Methods: We prospectively enrolled 68 patients with hip osteoarthritis scheduled for arthroplasty. Variables included manual examination of hip range of motion (H-ROM) and radiographic whole-body sagittal alignment parameters including sagittal vertical axis (SVA), center of acoustic meatus and femoral head offset (CAM-HA), thoracic kyphosis (TK), lumbar lordosis, sacral slope (SS), and knee flexion angle (KF). Read More

Orthopadie (Heidelb) 2022 Jul 23;51(7):547-555. Epub 2022 May 23.

Institut für Diagnostische und Interventionelle Radiologie/Neuroradiologie, Westküstenklinikum Heide, Akademisches Lehrkrankenhaus der Universitäten Kiel, Lübeck und Hamburg, Heide, Deutschland.

Background: The risk of osteoporotic insufficiency fractures (Fx) at the axial skeleton increases with decreasing bone density, with an accumulation in the thoracic and thoracolumbar regions. To better understand the differential distribution of Fx along the spine, morphological and osteodensitometric studies were performed by computed tomography (CT) in the various spine sections. In addition, we aimed to clarify whether Hounsfield units (HU) found on CT examinations from other indications correlate with bone density and could be grounds for osteologic diagnosis. Read More

Osteoporos Int 2022 Jul 1. Epub 2022 Jul 1.

Division of Endocrinology and Centre for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India.

Early diagnosis of hypophosphatasia (HPP) is challenging. Here, we propose to broaden the diagnostic criteria of HPP by reviewing published data on BMD and fractures in HPP patients. Non-osteoporotic fractures and higher than normal lumbar BMD were recurrent in HPP patients and could be included as diagnostic criteria. Read More

Skeletal Radiol 2022 Jul 1. Epub 2022 Jul 1.

Faculty of Medicine, Department of Pediatrics, Division of Pediatric Genetics, Dokuz Eylul University, İnciraltı mahallesi Mithatpaşa street no: 56, Balçova, İzmir, 35330, Turkey.

Introduction: Dominant pathogenic mutations in the TRPV4 gene give rise to a wide spectrum of abnormal phenotypes, including bone dysplasia as well as spinal muscular atrophy and hereditary motor and sensory neuropathy. Spondyloepimetaphyseal dysplasias (SEMDs) are autosomal dominant skeletal dysplasias characterized by mild epiphyseal dysplasia, flared metaphyses, prominent joints, spondyler dysplasia, and brachydactyly with various carpal, metacarpal, and finger malformations.

Case Presentation: We present a boy who has the clinical and radiological signs of SEMD-M with a dominant TRPV4 mutation. Read More

Pain Med 2022 Jul 1. Epub 2022 Jul 1.

Department of Orthopaedic Surgery & Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Objective: The present study aimed 1) to analyze the relative paraspinal autochthonous intramuscular fat volume before and after radiofrequency neurotomy (RFN), and 2) to compare it to the contralateral non-treated side.

Design: Retrospective cohort study.

Setting: Inselspital, University Hospital Bern, University of Bern. Read More

Afr J Paediatr Surg 2022 Jul-Sep;19(3):171-175

Department of Pediatric Surgery, Yopougon Teaching Hospital, Abidjan, Côte d'Ivoire.

Introduction: Scoliosis is the most frequent spine deformity in children. Epidemiological data are available in Western countries due to the systematic screening policies implemented at school. Unfortunately, in our country, there are neither national data nor screening policy for scoliosis. Read More

Bone Joint J 2022 Jul;104-B(7):820-825

Melbourne Orthopaedic Group, Melbourne, Australia.

Aims: Adverse spinal motion or balance (spine mobility) and adverse pelvic mobility, in combination, are often referred to as adverse spinopelvic mobility (SPM). A stiff lumbar spine, large posterior standing pelvic tilt, and severe sagittal spinal deformity have been identified as risk factors for increased hip instability. Adverse SPM can create functional malposition of the acetabular components and hence is an instability risk. Read More

J Frailty Sarcopenia Falls 2022 Jun 1;7(2):52-59. Epub 2022 Jun 1.

National Spinal Injuries Unit, Mater Misericordiae University Hospital, Dublin, Ireland.

Objectives: Sarcopenia is postulated to be an influential factor in chronic low back pain. The aim of this study is to evaluate the relationship between traditional clinical measures of sarcopenia and novel radiographic methods which evaluate overall muscle status, such as adjusted psoas cross-sectional area (APCSA) and degree of fat infiltration (%FI) in paraspinal muscles, in patients with chronic low back pain.

Methods: Prospective study performed at our institution from 01/01/19-01/04/19. Read More

Acta Inform Med 2022 Jun;30(2):115-120

Orthopaedic and Traumatology Department, Faculty of Medicine, University of Brawijaya, Saiful Anwar General Hospital, Malang, East Java, Indonesia.

Background: The number of lumbar spine surgery increased in recent years. Spinal instrumentation surgery was an integral component in the treatment of spinal pathologies, which can cause surgical site infection (SSI). Surgical site infections (SSIs) are the leading cause of mortality and morbidity after spinal instrumentation surgery. Read More

Cureus 2022 May 27;14(5):e25404. Epub 2022 May 27.

Department of Orthopedic Surgery, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, JPN.

Purpose Symptomatic postoperative spinal epidural hematoma (POSEH) is a complication of spine surgery that occurs infrequently but may cause ongoing serious neurological damage. Due to the narrow entry portal, the risk of hematoma is increased after microendoscopic laminectomy (MEL) compared with conventional open surgery, and the risk might be even higher for multivertebral MEL (m-MEL). The purpose of this study was to clarify the factors affecting the development of POSEH after m-MEL and identify the optimal order for the decompression of vertebral bodies. Read More

Arthroplast Today 2022 Aug 25;16:182-191. Epub 2022 Jun 25.

Department of Orthopaedics, Unit II, Christian Medical College Hospital, Vellore, Tamil Nadu, India.

Background: Fused hips with spine stiffness in ankylosing spondylitis (AS) reduce spinopelvic mobility. We aimed to assess spinopelvic mobility pattern and acetabular anteversion in AS after total hip arthroplasty (THA).

Material And Methods: Ninety-four stiff hips in 58 AS individuals (mean age: 37. Read More

Arthritis Res Ther 2022 Jun 30;24(1):161. Epub 2022 Jun 30.

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background/objective: Osteoporosis is a global health concern with an increasing prevalence worldwide. Denosumab is an antiresoptive agent that has been demonstrated to be effective and safe in osteoporotic patients. This study aimed to compare the efficacy and safety of the biosimilar denosumab candidate (Arylia) to the originator product (Prolia®) in postmenopausal osteoporotic patients. Read More

J Orthop Surg Res 2022 Jul 1;17(1):89. Epub 2022 Jul 1.

Clinic for Spinal Surgery, Schoen Clinic Hamburg Eilbek, Hamburg, Germany.

Background: The aim of this study was to investigate the influence of lumbar fusion and non-fusion surgery on the postoperative development of Modic changes (MCs).

Methods: A total of 270 patients who underwent lumbar fusion, microsequestrectomy, microdiscectomy, and microdecompression, and who were examined by pre- and postoperative magnetic resonance imaging during the period of January 2012 to December 2018, were included in this retrospective study. The incidence of new postoperative MCs and the change of volume of preexisting MCs after surgery were investigated. Read More

Med Biol Eng Comput 2022 Jun 30. Epub 2022 Jun 30.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781 039, Assam, India.

Lumbar spine fracture is typically treated by means of screw fixation, the primary aim of which is to reduce fracture by achieving bony union such that the spinal anatomy is restored. Pedicle screw fixation has certain advantages over conventional vertebral screws, e.g. Read More

Ann Nucl Med 2022 Jun 30. Epub 2022 Jun 30.

Department of Nuclear Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Objective: We aimed to compare the deep learning-based (VSBONE BSI) and atlas-based (BONENAVI) segmentation accuracy that have been developed to measure the bone scan index based on skeletal segmentation.

Methods: We retrospectively conducted bone scans for 383 patients with prostate cancer. These patients were divided into two groups: 208 patients were injected with Tc-hydroxymethylene diphosphonate processed by VSBONE BSI, and 175 patients were injected with Tc-methylene diphosphonate processed by BONENAVI. Read More

Int Orthop 2022 Jun 30. Epub 2022 Jun 30.

The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.

Purpose: Transoral approach can accomplish ventral decompression directly. However, surgical site infection (SSI) cannot be ignored. This paper aims to review the prevalence of infection and conduct advice for the treatment of SSI in the cervical spine following the transoral approach. Read More

Int J Spine Surg 2022 Jun;16(3):521-529

Department of Neurosurgery, Centro de Especialidades Médicas, Celaya, Guanajuato, Mèxico.

Background: Patients with epilepsy have a higher risk of skeletal injuries, and some of these fractures occur in the spine during a seizure. Seizure-induced spinal fractures (SISF) are unusual injuries that typically occur in the thoracolumbar spine. Because these skeletal injuries are not well described in the literature, this article aims to analyze the characteristics of this uncommon clinical entity. Read More

Int J Spine Surg 2022 Jun;16(3):472-480

Department of Orthopaedic Surgery, Zuyderland Medical Center, Heerlen, the Netherlands.

Background: The sacroiliac joint (SIJ) is affected in 14% to 22% in individuals presenting with chronic low back or buttock pain. This percentage is even higher in patients who underwent lumbar fusion surgery: 32% to 42%. Currently, there is no standard treatment or surgical indication for SIJ dysfunction. Read More

Int J Spine Surg 2022 Jun;16(3):540-547

Department of Neurosurgery, North Shore University Hospital - Hofstra School of Medicine, Manhasset, NY, USA.

Objective: Both under- and overcorrection are risk factors for junctional failure after deformity correction. This study investigates which factors determine the segmental radiographic outcome in mini-open lateral deformity surgery.

Methods: A single-center operative database was searched for patients undergoing multilevel mini-open lateral corrective surgery of degenerative spinal deformities. Read More

Int J Spine Surg 2022 Jun;16(3):450-457

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA.

Objective: To assess whether surgical cervical deformity (CD) patients meet spinopelvic age-adjusted alignment targets, reciprocal, and lower limb compensation changes.

Study Design: Retrospective review.

Methods: CD was defined as C2-C7 lordosis >10°, cervical sagittal vertical angle (cSVA) >4 cm, or T1 slope minus cervical lordosis (TS-CL) >20°. Read More

Int J Spine Surg 2022 Jun;16(3):505-511

Department of Orthopaedics and Spine Surgery, KEM Hospital, Mumbai, India.

Background: Preoperative lumbar epidural steroid injections (LESI) are known to be a risk factor for intraoperative dural tears in traditional spine surgery. However, whether the same holds true after minimally invasive surgery is debatable. The authors decided to investigate the incidence of complications in patients undergoing minimally invasive lumbar discectomy after a preoperative LESI. Read More

Int J Spine Surg 2022 Jun;16(3):530-539

Department of Orthopedics, Hospital for Special Surgery, New York, NY, USA.

Background: Persistent pelvic compensation following adult spinal deformity (ASD) corrective surgery may impair quality of life and result in persistent pathologic lower extremity compensation. Ideal age-specific alignment targets have been proposed to improve surgical outcomes, though it is unclear whether reaching these ideal targets reduces rates of pelvic nonresponse following surgery. Our aim was to assess the relationship between pelvic nonresponse, age-specific alignment, and lower-limb compensation following surgery for ASD. Read More

Int J Spine Surg 2022 Jun 30. Epub 2022 Jun 30.

Department of Orthopaedic Surgery, Maimonides Medical Center, Brooklyn, NY, USA.

Background: Research focused on the association of opioid use disorder (OUD) on postoperative outcomes in patients undergoing primary lumbar laminectomy is lacking. This study aims to observe the impact of OUD on (1) hospital length of stay (LOS), (2) readmission rates, (3) medical complications, and (4) health care expenditures.

Methods: A retrospective query was performed using a nationwide claims database from January 2005 to March 2014 for all patients who underwent lumbar laminectomy, yielding a total of 131,635 patients. Read More

Handb Clin Neurol 2022 ;186:205-227

Department of Surgical Neuromonitoring, University of California San Francisco, San Francisco, CA, United States.

The indications for neuromonitoring during lumbar stenosis surgery are defined by the risks associated with patient positioning, the approach, decompression of neural elements, deformity correction, and instrument implantation. The routine use of EMG and SEP alone during lumbar stenosis surgery is no longer supported by the literature. Lateral approach neuromonitoring with EMG only is also suspect. Read More

World Neurosurg 2022 Jun 27. Epub 2022 Jun 27.

Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina, United States.

Objective: To analyze the collective effect of social determinants of health (SDH) on lumbar spine revision surgery outcomes using a retrospective cohort study design.

Methods: Data from the Quality Outcomes Database were used, including 7,889 adults who received lumbar spine revision surgery and completed 3 and 12 months follow up. The SDH of interest included race/ethnicity, educational attainment, employment status, insurance payer, and gender. Read More

World Neurosurg 2022 Jun 27. Epub 2022 Jun 27.

Departments of Neurosurgery, Hallym University Sacred Heart Hospital, Anyang, Korea; Spine Center, Hallym University Sacred Heart Hospital, Anyang, Korea. Electronic address:

Background: Osteoporosis is a well-known risk factor of screw loosening. Classically, dual-energy x-ray absorptiometry (DEXA) scan is an easy and cost-effective method of detecting bone mineral density (BMD). However, T-score on DEXA scan can be overestimated in patients with degenerative changes of the spine. Read More

Accid Anal Prev 2022 Jun 27;174:106761. Epub 2022 Jun 27.

National Biomechanics Institute, 2708 Wilshire Blvd, #311, Santa Monica, CA 90403, USA. Electronic address:

Rear-end impacts are the most frequent type of the more than seven million motor vehicle collisions (MVCs) occurring annually in the United States. The cervical and lumbar spine are the most commonly injured sites as a result of rear-end collisions. The direction and magnitude of accelerations and forces to the spine are considered primary indicators of injury. Read More