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Int J Infect Dis 2022 Jun 24. Epub 2022 Jun 24.

Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

Objective: To study the clinical features of bacterial meningitis in myeloma patients.

Methods: We analyzed myeloma patients included in a nationwide cohort of patients >16 years old with community-acquired bacterial meningitis in the Netherlands between 2006 and 2018. Subsequently, we reviewed the literature for articles reporting myeloma patients with bacterial meningitis. Read More

Ochsner J 2022 ;22(2):169-175

Department of Neurocritical Care, Ochsner Clinic Foundation, New Orleans, LA.

Mucormycosis is a serious angioinvasive fungal infection. Immunocompromised patients are more likely to be susceptible to mucormycosis than immunocompetent individuals. Cerebral mucormycosis has been reported, but cases have primarily been unilateral. Read More

Cureus 2022 May 23;14(5):e25249. Epub 2022 May 23.

Internal Medicine, Michigan State University, East Lansing, USA.

Coccidioidomycosis is an endemic illness suspected in patients who live in or have recently traveled to an endemic area. Disseminated disease is less frequent and is almost always seen in the presence of risk factors such as immunosuppression. We present a case of disseminated coccidioidomycosis with a delayed presentation in a young immunocompetent male. Read More

BMC Neurol 2022 Jun 24;22(1):233. Epub 2022 Jun 24.

Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.

Background: The present case contributes to the limited literature on central nervous system involvement of blastic plasmacytoid dendritic cell neoplasm (BPDCN).  CASE PRESENTATION : A 63-year-old male presented to the department of neurology with a three-day history of rapidly progressing headache, fatigue, and confusion. Physical examination revealed multiple bruise-like skin lesions. Read More

J Neuroimaging 2022 Jun 24. Epub 2022 Jun 24.

Edward B. Singleton Department of Radiology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA.

Ataxia is one of the most common pediatric movement disorders and can be caused by a large number of congenital and acquired diseases affecting the cerebellum or the vestibular or sensory system. It is mainly characterized by gait abnormalities, dysmetria, intention tremor, dysdiadochokinesia, dysarthria, and nystagmus. In young children, ataxia may manifest as the inability or refusal to walk. Read More

FASEB J 2022 Jul;36(7):e22369

Lanzhou University Second Hospital, Lanzhou, PR China.

Intervertebral disc (IVD) degeneration (IVDD) is closely linked to degenerative spinal disease, resulting in disability, poor quality of life, and financial burden. Apoptosis of nucleus pulposus (NP) cells (NPCs) is a key pathological basis of IVDD. Periostin (POSTN), an extracellular matrix protein, is expressed in many tissues, whereas its abnormal expression is associated with IVDD. Read More

Brain Sci 2022 Jun 16;12(6). Epub 2022 Jun 16.

Department of Infectious Disease, Chongqing Public Health Medical Center, Chongqing 400036, China.

Cerebrospinal fluid (CSF) human immunodeficiency virus-1 (HIV-1) ribonucleic acid (RNA) at higher levels than in plasma has been observed in HIV-1-positive patients and defined as CSF/plasma discordance or CSF escape. Discordance is particularly seen in untreated patients with antiretroviral agents. Quantitative data regarding its association with blood-brain barrier (BBB) damage and intracranial co-infection with other pathogens are limited. Read More

Brain Sci 2022 Jun 7;12(6). Epub 2022 Jun 7.

Department of Neurosurgery, Keio University School of Medicine, Tokyo 160-8582, Japan.

Leptomeningeal carcinomatosis (LMC) is a rare but devastating complication of advanced cancer. Breast cancer, lung cancer, and melanoma are the three most common causes of LMC, whereas it is rare in ovarian cancer. Here, we report the case of a 59-year-old woman who was diagnosed with LMC from ovarian cancer and was successfully treated with intrathecal chemotherapy via Ommaya reservoir and radiation therapy. Read More

Cureus 2022 May 19;14(5):e25129. Epub 2022 May 19.

Department of Neurology, University of Florida, Gainesville, USA.

Checkpoint inhibitor immunotherapies have been one of the latest advances through the last decade in the treatment of various cancers. As their use is increasing so is the knowledge of their complications which can affect various organ systems including the central and peripheral nervous systems. Management of these complications requires stopping the offending agent and in some cases treating with immunosuppressive agents like intravenous steroids. Read More

Pediatr Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

Introduction Autologous bone dust replacement is a commonly used technique to seal a defect created from a burrhole. However, post-operative migration of these bone fragments may occur as an uncommon complication of endoscopic third ventriculostomy (ETV). Case Presentation We report 2 cases of intraventricular bone dust migration resulting in acute hydrocephalus from physical obstruction of the stoma and infection. Read More

Keio J Med 2022 Jun 17. Epub 2022 Jun 17.

Department of Emergency Medicine, University of Health Science, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.

The early diagnosis of central nervous system infections is of great importance to minimize morbidity and mortality. Neurogranin is a postsynaptic neural protein, and when the blood-brain barrier is damaged, neurogranin levels increase in both the cerebrospinal fluid and serum. The aim of this study was to evaluate the level of serum neurogranin and to investigate its utility in the diagnosis of central nervous system infections. Read More

Surv Ophthalmol 2022 Jun 16. Epub 2022 Jun 16.

Wills Eye Hospital, Philadelphia, Pennsylvania USA.

A 23-year-old man presented with new onset horizontal diplopia 5 months after a left orbital floor fracture. Examination revealed bilateral abduction deficits and disc swelling. Urgent MRI and MRI showed no significant abnormalities in the CNS. Read More

BMC Neurol 2022 Jun 18;22(1):224. Epub 2022 Jun 18.

Emergency Department, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a common type of autoimmune encephalitis. Patients with this condition are frequently very ill but are often misdiagnosed in the Emergency Department (ED). The objective of this study was to analyze the clinical characteristics of anti-NMDAR patients in the ED and to identify any associations with a diagnosis of anti-NMDAR encephalitis. Read More

Contrast Media Mol Imaging 2022 3;2022:1703250. Epub 2022 Jun 3.

Department of Outpatient, Harbin Red Cross Central Hospital, Harbin 150076, Heilongjiang, China.

The objective of this research was to explore the effect of perioperative anesthesia management for patients based on the concept of enhanced recovery after surgery (ERAS) and the application value of the computed tomography (CT) localization method in lumbar spinal nerve anesthesia, reducing the damage caused by anesthesia. One hundred and twenty patients who underwent the lumbar spinal anesthesia in lower limb surgery were selected as the research subjects. According to puncture positioning and nursing intention, the patients were classified into the control group with 30 patients (method of anatomical landmarks), CT group with 50 patients (the CT localization), and ERAS group with 40 patients (the CT localization and the ERAS management). Read More

Am J Case Rep 2022 Jun 16;23:e936179. Epub 2022 Jun 16.

Department of Orthopaedic and Spine Surgery, Evangelismos Hospital, Paphos, Cyprus.

BACKGROUND Pyogenic spondylitis comprises several clinical entities, including native vertebral osteomyelitis, septic discitis, pyogenic spondylodiscitis, and epidural abscess. The lumbar spine is most often infected, followed by the thoracic and cervical areas. It mainly develops (i) after spine surgery; (ii) from history of blunt trauma to the spinal column; (iii) from infections in adjacent structures (such as soft tissues); (iv) from iatrogenic inoculation after invasive procedures (such as lumbar puncture); and (v) from hematogenous bacterial spread to the vertebra (mainly through the venous route). Read More

Neurology 2022 Jun 15. Epub 2022 Jun 15.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School.

We are reporting a 68-year-old man with palmar rash, leg pain and inability to walk, whose neurologic examination localized to multiple roots, leading to the diagnosis of polyradiculopathy. Polyradiculopathy has both structural and non-structural etiologies. Structural etiologies include spinal stenosis, tethered cord syndrome, tumors, and leptomeningeal metastasis. Read More

Am Fam Physician 2022 Jun;105(6):616-624

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Stroke accounts for significant morbidity and mortality and is the fifth leading cause of death in the United States, with direct and indirect costs of more than $100 billion annually. Expedient recognition of acute neurologic deficits with appropriate history, physical examination, and glucose testing will help diagnose stroke and rule out mimicking presentations. The National Institutes of Health Stroke Scale should be used to determine stroke severity and to monitor for evolving changes in clinical presentation. Read More

Am J Transl Res 2022 15;14(5):3121-3131. Epub 2022 May 15.

Department of Spine Surgery, Xi'an Jiaotong University College of Medicine, Honghui Hospital No. 76 Nanguo Road, Xi'an 710054, Shaanxi, China.

Percutaneous Endoscopic Transforaminal Discectomy (PETD) has been widely used for minimally invasive treatment of lumbar disc herniation (LDH), and percutaneous disc target puncture has a steep learning curve and high radiation exposure. Proper technology grafting can improve the surgical procedure and clinical outcomes. The changes brought by grafting surgical robots into PETD are worth investigating. Read More

Cureus 2022 May 12;14(5):e24950. Epub 2022 May 12.

Division of Infectious Diseases, Aichi Cancer Center Hospital, Nagoya, JPN.

We report the case of a 69-year-old Japanese man who came to our hospital with a chief complaint of fever and cognitive decline for three weeks. There were no neurological abnormalities other than the decreased level of consciousness. He developed urinary retention after admission, so we performed a lumbar puncture, although his head and neck magnetic resonance imaging (MRI) showed no abnormal findings. Read More

Front Neurol 2022 27;13:810116. Epub 2022 May 27.

Midorigaoka Hoyoen Hospital, Oita, Japan.

Objective: Treatment of idiopathic normal-pressure hydrocephalus (iNPH) requires collaboration between dementia specialists and neurosurgeons. The role of dementia specialists is to differentiate patients with iNPH from patients with other dementia diseases and to determine if other dementia diseases are comorbid with iNPH. We conducted a nationwide hospital-based questionnaire survey on iNPH in medical centers for dementia (MCDs). Read More

Case Rep Orthop 2022 2;2022:7548593. Epub 2022 Jun 2.

Department of Orthopedics, Mayo Clinic Arizona, USA.

Introduction: This case report adds to current literature on management of a subdural hematoma following total knee arthroplasty and is particularly important as joint replacement moves into outpatient surgery centers where the orthopedic surgery team becomes the sole patient contact point. . A 66-year-old male presented to the emergency department five days after elective robotic-assisted left total knee arthroplasty performed with spinal epidural with the symptoms of a persistent nonpostural headache. Read More

Neurol Sci 2022 Jun 13. Epub 2022 Jun 13.

Department of Neurology, National Hospital for Neurology and Neurosurgery, London, UK.

BACKGROUND AND IMPORTANCE  : Classical infratentorial superficial siderosis (iSS) is characterised by repeated insidious bleeding into the subarachnoid space, leading to haemosiderin deposition within the subpial layers of the brainstem, cerebellum and spinal cord, sometimes with supratentorial involvement. Although nearly always associated with a dural defect (usually from previous trauma or neurosurgery) there is little evidence to support definitive investigation and management strategies. Here, we present a novel investigation strategy to identify a dural defect and subsequent successful surgical repair with biochemical resolution of subarachnoid bleeding. Read More

J Emerg Med 2022 Jun 9. Epub 2022 Jun 9.

State University of New York Downstate Medical Center, Brooklyn, New York; Kings County Hospital New York Health and Hospitals, Brooklyn, New York.

Background: Febrile neonates undergo lumbar puncture (LP), empiric antibiotic administration, and admission for increased risk of invasive bacterial infection (IBI), defined as bacteremia and meningitis.

Objective: Measure IBI prevalence in febrile neonates, and operating characteristics of Rochester Criteria (RC), Yale Observation Scale (YOS) score, and demographics as a low-risk screening tool.

Methods: Secondary analysis of healthy febrile infants < 60 days old presenting to any of 26 emergency departments in the Pediatric Emergency Care Applied Research Network between December 2008 and May 2013. Read More

J Vasc Interv Radiol 2022 Jun 9. Epub 2022 Jun 9.

Neuroradiology section, Department of Radiology, University of Alabama at Birmingham, 619 19th St S, Birmingham, AL 35249 USA. Electronic address:

Clin Neurol Neurosurg 2022 May 30;219:107316. Epub 2022 May 30.

Department of Neurosurgery, Tufts Medical Center, Boston, MA, USA. Electronic address:

Objective: The extreme elderly population (≥80 years of age) is expected to triple globally by 2050 and surgeries in this age group are likely to increase. Spinal anesthesia has emerged as a safe and effective alternative to general anesthesia in lumbar surgery and may particularly benefit extreme elderly patients concerned with post-operative cognitive dysfunction, poor physiological reserves, and polypharmacy. However, literature supporting its use in this population is lacking and there are potential challenges such as degenerative anatomy and medical comorbidities. Read More

Am J Emerg Med 2022 May 28. Epub 2022 May 28.

Chesapeake Regional Medical Center, Chesapeake, VA, USA.

Acute headache is a common emergency department (ED) chief complaint that usually has a benign course. Rare etiologies such as subarachnoid hemorrhage (SAH) can lead to extensive disability or even death. If suspected, SAH requires an intricate and intensive diagnostic investigation. Read More

Jpn J Radiol 2022 Jun 10. Epub 2022 Jun 10.

Department of Clinical Research, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, Fukuoka, 810-8563, Japan.

Purpose: Using the multi-detector computed tomography and related three-dimensional imaging technology, we developed a vertebral needle targeting simulation training system named spinal needling intervention practice using ray-summation imaging (SNIPURS). Herein, we assessed the utility of SNIPURS by evaluating changes in the learning curves of SNIPURS trainees.

Methods: Twenty-one examinees were enrolled: seven experienced operators (expert group), seven trainees with coaching (coaching group), and seven trainees without coaching (non-coaching group). Read More

Med Trop Sante Int 2021 09 4;1(3). Epub 2021 Sep 4.

Faculté des sciences de la santé, Université de Lomé, Lomé, Togo.

Introduction: In sub-Saharan Africa characterized by limited resources especially in health facilities and a relatively higher frequency of infectious diseases, studies on Guillain-Barré syndrome (GBS) are rare.

Objectives: The objectives of this work are to describe the characteristics of GBS in Togo through a cohort of patients followed in the neurology unit of the Campus University Hospital of Lomé.

Methodology: The study took place from May 2015 to July 2019. Read More

Int J Clin Pract 2022 9;2022:7770214. Epub 2022 May 9.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Background: Percutaneous kyphoplasty (PKP) is an effective minimally invasive technique for the treatment of osteoporotic vertebral fracture (OVF) in recent years. This study focuses on the analysis of PKP surgery and anesthesia in osteoporotic vertebral facture patients over 90 years old with the concept of "enhanced recovery after surgery."

Methods: This study reviewed 239 patients who were diagnosed with OVF retrospectively between October 2015 and June 2019. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2022 Jun;30(3):937-942

Department of Hematology, Wuhan No.1 Hospital, Wuhan 430022, Hubei Province, China,E-mail:

Objective: To investigate the safety and efficacy of a new proteasome inhibitor Ixazomib followed by autologous hematopoietic stem cell transplantation (AHSCT) in the treatment of POEMS syndrome.

Methods: The clinical manifestations, diagnosis and treatment process and follow-up results of 4 patients with POEMS syndrome who were treated with Ixazomib-based regimen combined with AHSCT in Wuhan No.1 Hospital from February 2018 to July 2020 were analyzed retrospectively. Read More