Search Our Scientific Publications & Authors

Mol Cell Biochem 2022 Jun 23. Epub 2022 Jun 23.

Neurobiology Research Unit, University Hospital Copenhagen, Rigshospitalet, 4-6, Inge Lehmanns vej, 2100, Copenhagen, Denmark.

Transient receptor potential (TRP) channels are widely expressed cation channels that play an essential role in mediating Ca2+ homeostasis and are considered potential regulators of inflammatory pain. This study investigates the expression of the TRP channel subtypes TRPV1, TRPV4, TRPC6, TRPM2, TRPM8 in lumbar intervertebral disc (IVD) biopsies from patients with chronic low back pain (LBP). We determined the expression of these TRP channel subtypes in the annulus fibrosus (AF) and the nucleus pulposus (NP) from 46 patients with LBP undergoing 1-2 level lumbar fusion surgery for degenerative disc disease. Read More

Connect Tissue Res 2022 Jun 23:1-18. Epub 2022 Jun 23.

The second clinical medical college, Lanzhou University, Lanzhou, Gansu, PR China.

Intervertebral disc degeneration (IDD) is a common age-related disease with clinical manifestations of lumbar and leg pain and limited mobility. The pathogenesis of IDD is mainly mediated by the death of intervertebral disc (IVD) cells and the imbalance of extracellular matrix (ECM) synthesis and degradation. Oxidative stress and inflammatory reactions are the important factors causing this pathological change. Read More

Front Endocrinol (Lausanne) 2022 6;13:890371. Epub 2022 Jun 6.

Department of Spinal Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.

Aim: Accurate severity grading of lumbar spine disease by magnetic resonance images (MRIs) plays an important role in selecting appropriate treatment for the disease. However, interpreting these complex MRIs is a repetitive and time-consuming workload for clinicians, especially radiologists. Here, we aim to develop a multi-task classification model based on artificial intelligence for automated grading of lumbar disc herniation (LDH), lumbar central canal stenosis (LCCS) and lumbar nerve roots compression (LNRC) at lumbar axial MRIs. Read More

J Orthop Surg Res 2022 Jun 21;17(1):325. Epub 2022 Jun 21.

Department of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Jing'an District, Shanghai, 200040, China.

Objective: To investigate the biomechanical effects of interbody cage height on adjacent segments in patients with lumbar degeneration undergoing transforaminal lumbar interbody fusion (TLIF) surgery, so as to provide references for selection of interbody cage.

Methods: The finite element model of normal lower lumbar spine (L3-S1) was built and validated, then constructed three different degenerative segments in L3-L4, and the cages with different height (8, 10, 12, 14 mm) were implanted into L4-L5 disc. All the twelve models were loaded with pure moment of 7. Read More

BMC Musculoskelet Disord 2022 Jun 20;23(1):594. Epub 2022 Jun 20.

Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Hebei province, Shijiazhuang, China.

Background: Percutaneous cement discoplasty (PCD) is a minimally invasive treatment for degenerative lumbar spine disease, but the relationship between decompression effect on the nerve root and different doses of bone cement is uncertain.

Purpose: To investigate the indirect decompression effect of cement with different doses on nerve roots and the biomechanical changes on the spine during PCD using finite element analysis (FEA).

Methods: FEA was adapted to analyze the mechanical changes in the lumbar vertebrae before and after the application of PCD. Read More

J Exp Orthop 2022 Jun 17;9(1):56. Epub 2022 Jun 17.

Ramsay Santé, Hôpital Privé Jean Mermoz, Lyon, France.

Purpose: To determine within-patient fusion rates of chambers filled with bioactive glass versus autologous iliac crest bone on computed tomography (CT) following anterior lumbar interbody fusion (ALIF).

Methods: A consecutive series of 40 patients (58 levels) that underwent single-level (L5-S1 only) or two-level (L5-S1 and L4-L5) ALIF were assessed. Indications for fusion were one or more of the following: degenerative disc disease with or without Modic changes, spondylolisthesis, and stenosis. Read More

Sci Rep 2022 Jun 15;12(1):9939. Epub 2022 Jun 15.

Department of Orthopedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501, Japan.

A thorough understanding of lumbar segmental motion is valuable to treat patients with degenerative lumbar disease, but kinematics associated with indicators of lumbar intervertebral instability [traction spur, Modic changes (MCs) and vacuum phenomenon (VP)] in the lumbar spine have not been well understood. The purpose of this study is to evaluate the relationships between traction spur, MCs and VP to radiographic measurements in the lumbar spine. A total of 525 lumbar discs from L1-2 to L5-S1 of 105 patients were evaluated. Read More

Rom J Morphol Embryol 2021 Oct-Dec;62(4):951-960

Department of Urology, University of Medicine and Pharmacy of Craiova, Romania; Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania;

Lumbar herniated disc is the most frequent cause for lumbar pain. It is caused by degenerative, macroscopic and microscopic changes of the intervertebral discs. It is a chronic disease, with periods of exacerbation and remission under drug and physiotherapeutic treatment. Read More

BMC Med Imaging 2022 Jun 4;22(1):108. Epub 2022 Jun 4.

Department of Radiology, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: Studies on MRI findings among patients with LBP have been conducted; especially among adolescents and young adult population in developed countries. However, MRI lumbar spine evaluation findings in young adult patients with low back pain in Uganda is not known. The purpose of this study was to determine the MRI findings and their correlation to clinical features in young adult patients with low back pain in Nsambya hospital. Read More

Khirurgiia (Mosk) 2022 (6):72-79

Irkutsk Research Center of Surgery and Traumatology, Irkutsk, Russia.

Objective: To develop a new validated classification of intervertebral disc degeneration.

Material And Methods: A retrospective observational single-center study included medical records of patients with and without degenerative disease of lumbar intervertebral discs. The interval values of apparent diffusion coefficient (ADC) of intervertebral discs were grouped into degeneration classes. Read More

Trials 2022 May 28;23(1):446. Epub 2022 May 28.

Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China.

Background: Lumbar disc herniation (LDH) is a common and frequently occurring disease in clinics. Low back pain and sciatica are the presenting symptoms of LDH. To some extent, it can be considered that measures with the capability to improve low back pain or sciatica have the potential to treat LDH. Read More

Int J Environ Res Public Health 2022 05 14;19(10). Epub 2022 May 14.

Department of Orthopaedic Surgery, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 200, 00128 Rome, Italy.

Low Back Pain (LBP) is currently the first cause of disability in the world, with a significant socioeconomic burden. Diagnosis and treatment of LBP often involve a multidisciplinary, individualized approach consisting of several outcome measures and imaging data along with emerging technologies. The increased amount of data generated in this process has led to the development of methods related to artificial intelligence (AI), and to computer-aided diagnosis (CAD) in particular, which aim to assist and improve the diagnosis and treatment of LBP. Read More

Oxid Med Cell Longev 2022 14;2022:3861380. Epub 2022 May 14.

Department of Arthrology, Hunan Provincial People's Hospital, Changsha 410001, China.

Objective: Here, we aimed to explore the main mechanism of Yaobishu (YBS) in lumbar disc herniation (LDH).

Methods And Results: Eighteen compounds that might act on LDH were obtained through a combination of network pharmacology prediction and identification by high-performance liquid chromatography-mass spectrometry. The key compounds were palmitic acid and trans-4-hydroxy-3-methoxycinnamate (cinnamate). Read More

Neural Plast 2022 14;2022:7912410. Epub 2022 May 14.

Department of Orthopedics, Renhe Hospital, Baoshan District, Shanghai 200431, China.

Lumbar disc herniation (LDH) induced nerve compression syndromes have been a prevalent problem with complex neural mechanisms. Changes in distributed brain areas are involved in the occurrence and persistence of syndromes. The present study aimed to investigate the changes of brain functional network in LDH patients with chronic sciatica using graph theory analysis. Read More

BMC Musculoskelet Disord 2022 May 20;23(1):480. Epub 2022 May 20.

Department of Orthopedics, Beijing Chao-Yang Hospital, Capital Medical University, GongTiNanLu 8#, Chao-Yang District, Beijing, 100020, China.

Study Design: Retrospective cohort study.

Objective: To compare the early radiographic adjacent segment degeneration (R-ASD) and regional lumbar sagittal alignment after midline lumbar interbody fusion (MIDLIF) with cortical bone trajectory (CBT) screw fixation (CBT-MIDLIF) and posterior lumbar interbody fusion (PLIF) with the traditional pedicle screw fixation (PS-PLIF) during long-term follow-up.

Methods: All patients who underwent CBT-MIDLIF or PS-PLIF were identified by a retrospective consecutive case review. Read More

J Neurosurg Spine 2022 May 20:1-7. Epub 2022 May 20.

1Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh.

Objective: Cage subsidence is a well-known phenomenon after lateral lumbar interbody fusion (LLIF), occurring in 10%-20% of cases. A 3D-printed porous titanium (pTi) cage has a stiffness that mimics the modulus of elasticity of native vertebrae, which reduces stress at the bone-hardware interface, lowering the risk of subsidence. In this study, the authors evaluated their institutional rate of subsidence and resultant reoperation in patients who underwent LLIF using a 3D-printed pTi interbody cage. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2022 May;36(5):592-599

Department of Mininlally Invasive Spine Surgery, Luoyang Orthopedic Hospital of Henan Province (Orthopedic Hospital of Henan Province), Zhengzhou Henan, 450016, P. R. China.

Objective: To compare the clinical and radiological outcomes of unilateral biportal endoscopic transforaminal lumbar interbody fusion (UBE-TLIF) and minimally invasive tubular TLIF (MT-TLIF) in treatment of lumbar degenerative diseases.

Methods: A clinical data of 75 patients with lumbar degenerative diseases, who met the selection criteria between August 2019 and August 2020, was retrospectively analyzed, including 35 patients in the UBE- TLIF group and 40 patients in the MT-TLIF group. There was no significant difference in general data such as gender, age, body mass index, disease type and duration, and surgical segment between the two groups ( >0. Read More

Dermatol Ther 2022 May 15:e15585. Epub 2022 May 15.

Department of Dermatology, İstanbul Training and Research Hospital, University of Health Sciences, İstanbul, Turkey.

Behçet's disease (BD) is a chronic systemic vasculitis with a wide range of clinical findings. It has both autoinflammatory and autoimmune features and manifests with recurrent inflammatory attacks involving the innate immune system. Recently, autoinflammation has started to take place in the pathogenesis of intervertebral disc degeneration. Read More

Int J Environ Res Public Health 2022 05 7;19(9). Epub 2022 May 7.

Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.

Background: The aim of our observational study is to compare the therapeutic efficacy of combined treatment of oxygen-ozone therapy and oral treatment with alpha-lipoic acid (ALA) + palmitoylethanolamide (PEA) and myrrh in patients with peripheral neuropathic pain (sciatica) on radicular disc conflict from disc herniation and the results obtained with oxygen-ozone treatment alone.

Methods: We enrolled 318 patients with the neuroradiological diagnosis of disc herniation performed with computed tomography (CT) or magnetic resonance imaging (MRI) and symptoms characterized by low back pain complicated by sciatica, which we divided into two groups. Group A was composed of 165 patients who were treated only with oxygen-ozone therapy with CT-guided intraforaminal technique, while the remaining 153 (Group B) have undergone combined oral treatment with ALA + PEA and myrrh. Read More

PLoS One 2022 13;17(5):e0267384. Epub 2022 May 13.

Novosibirsk State University, Novosibirsk, Russia.

Lumbar intervertebral disc degeneration (DD) disease is one of the main risk factors for low back pain and a leading cause of population absenteeism and disability worldwide. Despite a variety of biological studies, lumbar DD is not yet fully understood, partially because there are only few studies that use systematic and integrative approaches. This urges the need for studies that integrate different omics (including genomics and transcriptomics) measured on samples within a single cohort. Read More

Aerosp Med Hum Perform 2022 May;93(5):415-420

Obstructive sleep apnea (OSA) is a condition characterized by disrupted sleep and excessive daytime fatigue. Associated cognitive and psychomotor decrements pose a threat to aviators' performance and flight safety. Additionally, the longer term health effects associated with the disease can jeopardize an aviator's career and negatively impact operational outputs. Read More

Neurol India 2022 Mar-Apr;70(2):510-514

Department of Spine Surgery Bumin Hospital, Busan, South Korea.

Background And Introduction: Minimally invasive spine surgery (MISS) is a set of techniques and procedures that reduces the local tissue injury while achieving the same results through traditional open surgery. The techniques for the treatment of lumbar disc herniation and degenerative canal stenosis have evolved from tubular discectomy to endoscopic discectomy. This helps in preserving spine function. Read More

Appl Bionics Biomech 2022 29;2022:6803124. Epub 2022 Apr 29.

Wuhan No.4 Hospital, WuHan 430000, China.

Compared with traditional acupuncture, it is urgently needed for more effective method for the disease to serve the clinical treatment. This paper combines acupuncture and massage to treat lumbar intervertebral disc protrusion, uses a controlled trial to study the clinical effects of acupuncture combined with massage for the treatment of lumbar intervertebral disc protrusion, combines mathematical statistics to test the data, and compares and analyzes the statistical object parameters. Through experimental research, it is known that in the treatment of lumbar intervertebral disc protrusion, in order to obtain a faster and better effect, traditional acupuncture treatment should be combined with massage therapy. Read More

Eur Spine J 2022 May 6;31(5):1088-1098. Epub 2022 May 6.

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 1108 th Street, JEC 7044, Troy, NY, 12180, USA.

Background: The intervertebral disc degenerates with age and has a poor propensity for regeneration. Small molecule transport plays a key role in long-term degradation and repair. Convection (bulk flow), induced by low rate cyclic loading of the intervertebral disc, has been shown to increase transport of small molecules. Read More

Global Spine J 2022 May 2:21925682221099471. Epub 2022 May 2.

Department of Orthopedic Surgery, 21611Columbia University, New York, NY, USA.

Study Design: Cadaveric specimens.

Objective: To perform a pathomorphological analysis of the degree of facet joint (FJ) degeneration utilizing fresh cadaveric models and correlating these structural changes with imaging findings.

Methods: L1-L5 FSU including all tissue between the anterior longitudinal ligament to the posterior spinal structures were obtained on 28 patients at a mean of 5. Read More

Bone Joint J 2022 May;104-B(5):627-632

Departments of Clinical Sciences and Orthopaedics, Clinical and Molecular Osteoporosis Research Unit, Lund University, Skåne University Hospital, Malmö, Sweden.

Aims: Lumbar disc prolapse is a frequent indication for surgery. The few available long-term follow-up studies focus mainly on repeated surgery for recurrent disease. The aim of this study was to analyze all reasons for additional surgery for patients operated on for a primary lumbar disc prolapse. Read More

Orthop Surg 2022 Jun 28;14(6):1126-1134. Epub 2022 Apr 28.

Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.

Objective: To evaluate the outcomes of oblique lumbar interbody fusion (OLIF) combined with anterolateral single-rod screw fixation (AF) in treating two-segment lumbar degenerative disc disease (LDDD) and to determine whether AF can maintain the surgical results.

Methods: A retrospective analysis was performed on patients who underwent OLIF combined with AF (OLIF-AF) for LDDD at the L3-5 levels between October 2017 and May 2018. A total of 84 patients, including 44 males and 40 females, with a mean age of 62. Read More

Am J Case Rep 2022 Apr 27;23:e935208. Epub 2022 Apr 27.

Continuing Medical Education, Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, Colombia.

BACKGROUND The intervertebral disc extrusion resorption has been described in the literature by various authors. It occurs in up to 75% of patients with symptomatic extruded lumbar discs. The Atlasprofilax method favors osteo-musculo-articular rehabilitation processes, mainly impacting on 2 levels: the first is the bone anatomy of the atlanto-occipital joint, and the second is the fasciae located in the cervical region. Read More

Trials 2022 Apr 23;23(1):338. Epub 2022 Apr 23.

Shi's Center of Orthopedics and Traumatology (Institute of Traumatology, Shuguang Hospital), Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Background: Lumbar disc herniation (LDH) is a common chronic musculoskeletal disorder that seriously affects quality of life. The percutaneous endoscopic lumbar diskectomy (PELD) technique was developed to address spinal nerve root compression through direct visualization of pathological findings while minimizing tissue destruction upon exposure. It is an effective and safe treatment for LDH. Read More

BMC Musculoskelet Disord 2022 Apr 23;23(1):382. Epub 2022 Apr 23.

Department of Engineering, University of Exeter, Exeter, UK.

Background Context: Lumbar total disc replacement (TDR) is an alternative to lumbar fusion in the treatment of lower back pain and reduces the risk of adjacent segment degeneration. Heterotopic ossification (HO) has been identified as a common complication following lumbar TDR.

Purpose: This systematic review aims to determine the prevalence, risk factors and clinical and radiological impact of HO following lumbar TDR. Read More