119,207 results match your criteria Lumbar Degenerative Disk Disease


Radicular Pain Syndromes: Cervical, Lumbar, and Spinal Stenosis.

Semin Neurol 2018 Dec 6;38(6):634-639. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts.

Back pain is a top primary and urgent care complaint; radicular pain can be caused by herniation of the nucleus pulposus (intervertebral disc), spinal stenosis, or degenerative changes to the vertebrae. The focus of this clinical review will be the clinical approach and treatment of lumbar radicular pain, cervical radicular pain, and spinal stenosis. Usually localized through neurological history, exam, and imaging, specific signs and symptoms for lumbar radicular, spinal stenosis, and cervical radicular pain can help determine etiology. Read More

View Article
December 2018
1 Read

Blocking TRPA1 and TNF-α Signal Improves Bortezomib-Induced Neuropathic Pain.

Cell Physiol Biochem 2018 Dec 6;51(5):2098-2110. Epub 2018 Dec 6.

Background/aims: Bortezomib (BTZ) is largely used as a chemotherapeutic agent for the treatment of multiple myeloma. However, one of the significant limiting complications of BTZ is painful peripheral neuropathy during BTZ therapy. The purpose of this study was to examine the underlying mechanisms leading to neuropathic pain induced by BTZ. Read More

View Article
December 2018
1 Read

Spinal arachnoiditis ossificans: report of a quadruple triggered case.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurological Surgery, Policlinico "G. Rodolico" University Hospital, Via Santa Sofia 86, 95123 - Catania, Italy.

Background: Arachnoiditis ossificans (AO) is a rare condition often associated with previous spine surgery. Here we describe a unique case of a patient affected by ankylosing spondylitis (AS), presenting with progressive neurological deterioration due to AO. We also review the literature on evaluation and management of patients suffering from AO. Read More

View Article
December 2018
1 Read

Locomotor central pattern generator excitability states and serotonin sensitivity after spontaneous recovery from a neonatal lumbar spinal cord injury.

Brain Res 2018 Dec 3. Epub 2018 Dec 3.

Norwegian Center for Stem Cell Research, Oslo University Hospital, Norway. Electronic address:

The spinal locomotor central pattern generator (CPG) in neonatal mice exhibits diverse output patterns, ranging from sub-rhythmic to multi-rhythmic to fictive locomotion, depending on its general level of excitation and neuromodulatory status (Sharples and Whelan, 2017). We have recently reported that the locomotor CPG in neonatal mice rapidly recovers the ability to produce neurochemically induced fictive locomotion following an upper lumbar spinal cord compression injury (Züchner et al., 2018). Read More

View Article
December 2018
1 Read

The effect of spinal mobilization with leg movement in patients with lumbar radiculopathy - A double blind randomized controlled trial.

Arch Phys Med Rehabil 2018 Dec 3. Epub 2018 Dec 3.

Professorand Head, Department of Orthopaedics, Smt. Kashibai Navale Medical College and General Hospintal, Pune, Maharashatra, India.

Objectives: To evaluate the effect of spinal mobilization with leg movement (SMWLM) on low back and leg pain intensity, disability, pain centralization and patient satisfaction in subjects with lumbar radiculopathy.

Design: A double blind randomized controlled trial.

Setting: General Hospital PARTICIPANTS: Sixty adults (mean age 44 years) with sub-acute lumbar radiculopathy INTERVENTIONS: Subjects were randomly allocated to receive SMWLM, exercise and electrotherapy (n = 30) or exercise and electrotherapy alone (n = 30). Read More

View Article
December 2018

Feasibility of the annulus fibrosus repair with in situ gelating hydrogels - A biomechanical study.

PLoS One 2018 6;13(12):e0208460. Epub 2018 Dec 6.

Department of Orthopedics, Balgrist University Hospital, Zurich, Switzerland.

The surgical standard of care for lumbar discectomy leaves the annulus fibrosus (AF) defect unrepaired, despite considerable risk for a recurrent herniation. Identification of a viable defect repair strategy has until now been elusive. The scope of this ex vivo biomechanical study was to evaluate crosslinking hydrogels as potentially promising AF defect sealants, and provide a baseline for their use in combination with collagen scaffolds that restore disc volume. Read More

View Article
December 2018
2 Reads

A pragmatic cluster randomised controlled trial of a tailored intervention to improve the initial management of suspected encephalitis.

PLoS One 2018 6;13(12):e0202257. Epub 2018 Dec 6.

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.

Objective: To determine whether a tailored multifaceted implementation strategy improves the initial management of patients with suspected encephalitis.

Design: Pragmatic two arm cluster randomised controlled trial.

Setting: Hospitals within the United Kingdom. Read More

View Article
December 2018
6 Reads

S1 Pedicle Subtraction Osteotomy for Fixed Sagittal Imbalance and Lumbosacral Kyphosis.

Clin Spine Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, New York, NY.

S1 pedicle subtraction osteotomies (PSOs) are indicated in patients with fixed, high-grade L5-S1 spondylolisthesis or kyphosis secondary to a sacral fracture, who present with severe sagittal imbalance. Unlike lumbar PSOs, sacral osteotomies are rare, and there is a paucity of literature outlining techniques. Here, we present the indications, planning, technique, and outcomes for S1 PSOs. Read More

View Article
December 2018
1 Read

Anatomic Considerations in the Lateral Transpsoas Interbody Fusion: The Impact of Age, Sex, BMI, and Scoliosis.

Clin Spine Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedic Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.

Study Design: This is a retrospective case series.

Objective: Define the anatomic variations and the risk factors for such within the operative corridor of the transpsoas lateral interbody fusion.

Summary Of Background Data: The lateral interbody fusion approach has recently been associated with devastating complications such as injury to the lumbosacral plexus, surrounding vasculature, and bowel. Read More

View Article
December 2018

Peripheral inflammation accelerates the onset of mechanical hypersensitivity after spinal cord injury and engages TNFα signaling mechanisms.

J Neurotrauma 2018 Dec 6. Epub 2018 Dec 6.

Emory University School of Medicine, 12239, Department of Physiology , 615 Michael Street , Atlanta, Georgia, United States , 30322 ;

Previously, we showed that noxious stimulation of the tail produces numerous detrimental effects after spinal cord injury (SCI), including an earlier onset and increased magnitude of mechanical hypersensitivity. Expanding on these observations, this study sought to determine whether localized peripheral inflammation similarly impacts the expression of mechanical hypersensitivity after SCI. Adult rats received a moderate contusion injury at thoracic level (Tl0) or sham surgery, and were administered complete Freund's adjuvant (CFA) or vehicle in one hind paw 24 hours later. Read More

View Article
December 2018
3 Reads

The change of volume of the lumbar vertebrae along with aging in asymptomatic population: a preliminary analysis.

Acta Bioeng Biomech 2018 ;20(4):25-30

Department of Orthopedics and Traumatology, W. Dega University Hospital, Poznań, Poland.

Introduction: Previous studies have demonstrated that the length of the lumbar spine is decreasing with age. Despite considerable research based on sagittal measurements, little is known about the changes in the volume of vertebrae. The objective of this study was to evaluate the changes in the volume of either column of the spine with age. Read More

View Article
January 2018
1 Read

Effects of physical exercise in winter training conditions on the thermographic temperature distribution of the horse rider's skin.

Acta Bioeng Biomech 2018 ;20(4):133-137

Department of Biomedical Engineering, UTP University of Science and Technology, Bydgoszcz, Poland.

Purpose: The purpose of this work was to assess the impact of a specific equestrian training, conducted in winter weather conditions, on the thermovision temperature distribution of a rider's body surface. The study included a riding pair with 12 years of experience (female rider, aged 25, sports active and 16-year-old horse, Trakehner breed).

Methods: The study included the temperature distribution of selected parts of the rider's body (the area of the right and left shoulder blade, chest and lumbar section, and the region of the left and right cross) was carried out before and after recreational, jumping and dressage training. Read More

View Article
January 2018
2 Reads

Mediolateral and dorsoventral projection patterns of cutaneous afferents within transverse planes of the mouse spinal dorsal horn.

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Department of Physiology, Teikyo University School of Medicine, Tokyo, Japan.

The central projection patterns of cutaneous afferents from the forelimb and shoulder of mice were studied in the spinal dorsal horn after intracutaneous injection of AlexaFluor 488-conjugated and/or 594-conjugated cholera toxin subunit B (CTB). Based on their dermatomes, the following eight skin regions are thought to be innervated by spinal nerves from the sixth to eighth cervical spinal nerve roots: the dorsal surface of the shoulder, brachium, proximal forearm, distal forearm, hand, palmar surface of the second and third digits, and palm. The termination areas of afferents from the dorsal surface of the shoulder and forearm were narrow, distributed in a dorsoventral direction, and aligned in order from lateral to medial within the sixth to eighth cervical dorsal horns. Read More

View Article
December 2018
1 Read

Incidence and endovascular treatment of severe spontaneous non-cerebral bleeding: a single-institution experience.

Eur Radiol 2018 Dec 5. Epub 2018 Dec 5.

2nd Department of Radiology, Division of Interventional Radiology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Objectives: To investigate the incidence and endovascular treatment of severe spontaneous non-cerebral hemorrhage (SSNCH) in a high-volume, tertiary university hospital.

Methods: All patients diagnosed with SSNCH between January 2016 and June 2017 were retrospectively analyzed. Endovascular treatment (group EVT) was offered only in patients demonstrating active bleeding at CT angiography (CTA). Read More

View Article
December 2018
2 Reads

Opioid Use is Associated with Higher Severity-Adjusted Episode Costs in Patients with Conservatively Managed Degenerative Joint Disease of the Back and Neck.

Pharmacoeconomics 2018 Dec 6. Epub 2018 Dec 6.

Clinical Data Services and Analytics, UnitedHealthcare, 9700 Health Care Lane, Minnetonka, MN, 55343, USA.

Background: Opioid use and misuse are urgent health issues. Previous studies suggest that opioid use increases healthcare resource use but severity adjustment is lacking.

Objective: The objective of this study was to evaluate the severity-adjusted cost difference between opioid users and non-users among patients with conservatively managed degenerative joint disease of the spine within a large commercial health plan population in the United States. Read More

View Article
December 2018
1 Read

Is Vibration Training Good for Your Bones? An Overview of Systematic Reviews.

Biomed Res Int 2018 4;2018:5178284. Epub 2018 Nov 4.

Faculty of Health and Sport Science (FCSD), Department of Physiatry and Nursing. Universidad de Zaragoza, Ronda Misericordia 5, 22001 Huesca, Spain.

Whole-body vibration (WBV) intervention studies and reviews have been increasing lately. However, the results regarding its effects on bone tissue in different populations are still inconclusive. The goal of this overview was to summarize systematic reviews assessing the effects of WBV training on bone parameters. Read More

View Article
November 2018
1 Read

Association between brown adipose tissue and bone mineral density in humans.

Int J Obes (Lond) 2018 Dec 5. Epub 2018 Dec 5.

PROFITH "PROmoting FITness and Health through physical activity" research group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Ctra. de Alfacar s/n, C.P., 18071, Granada, Spain.

Background: Brown adipose tissue (BAT) seems to play a role in bone morphogenesis. A negative association has been reported between BAT and bone mineral density (BMD) in women, but not in men. A panel of experts has recently published a set of recommendations for BAT assessment, and thus, to re-address previously reported associations is needed. Read More

View Article
December 2018
1 Read

Does the Cage Position in Transforaminal Lumbar Interbody Fusion Determine Unilateral versus Bilateral Screw Placement?: A Review of the Literature.

Asian Spine J 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.

This literature review examines the relative placement of the interbody cage with respect to the unilateral screw construct to address the need for bilateral screw placement versus unilateral screw placement. Transforaminal lumbar interbody fusion (TLIF) has become a widely used technique for correcting lumbar intervertebral pathologies. This review addresses the necessity for further study on the effects of the relative position of intervertebral cage placement on the outcome of lumbar spine surgery after TLIF with unilateral pedicle screw fixation. Read More

View Article
December 2018

Predictors of clinical success with stabilization exercise are associated with lower levels of lumbar multifidus intramuscular adipose tissue in patients with low back pain.

Disabil Rehabil 2018 Dec 3:1-7. Epub 2018 Dec 3.

a Faculty of Kinesiology , University of New Brunswick , Canada.

Purpose: Investigate the construct validity of prognostic factors purported to predict clinical success with stabilization exercise for low back pain by exploring their associations with lumbar multifidus composition.

Methods: Patients with low back pain were recruited from a hospital imaging department. The presence of fivepredictors (age <40 years, positive prone instability test, aberrant trunk flexion movements, straight leg raise range of motion >91°, spinal hypermobility) were identified by standardized physical examination. Read More

View Article
December 2018
1 Read

A new propeller trapezius muscle flap for reconstruction of posterior trunk defects: An anatomic study and report of three cases.

Microsurgery 2018 Dec 3. Epub 2018 Dec 3.

Department of Plastic and Reconstructive Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Reconstruction of complex back defects, especially after corrective spine surgery, is a challenging problem. In these patients hardware issues predominate and flap failure has serious consequences. Certain subunits of the back pose even greater problems, specifically the central region between T9 and T12. Read More

View Article
December 2018

Tubular Transforaminal Lumbar Interbody Fusion is Superior to a Midline Incision With Cortical Screws for a Minimally Invasive Interbody Fusion.

Clin Spine Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL.

View Article
November 2018
1 Read

Leg Muscle Strength After Lateral Interbody Fusion Surgery Recovers Over Time After Temporary Muscle Weakness.

Clin Spine Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.

Study Design: Case-control study.

Objective: The objective of this study was to reveal the changes of leg muscle strength after lateral interbody fusion (LIF).

Summary Of Background Data: Muscle trauma and damage to intermuscular nerves due to dissection of the psoas are recognized perioperative complications of LIF. Read More

View Article
November 2018

Skin breakdown of the feet in patients with spina bifida: Analysis of risk factors.

J Pediatr Rehabil Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.

Purpose: Recent studies on patients with spina bifida have noted an increased incidence of skin breakdown with more proximal functional neurologic level. We hypothesized that there would be an inverse relationship between skin breakdown of the foot and severity of functional level of lesion, because patients with more caudal levels of lesion spend more time ambulating.

Methods: The National Spina Bifida Patient Registry (NSBPR) at Children's of Alabama was queried for the presence of skin breakdown of the foot, ambulatory status, functional neurologic level, and diagnosis of myelomeningocoele (MMC) vs. Read More

View Article
November 2018
1 Read

Immediate effects of isometric trunk stabilization exercises with suspension device on flexion extension ratio and strength in chronic low back pain patientss.

J Back Musculoskelet Rehabil 2018 Nov 19. Epub 2018 Nov 19.

Background: Recent clinical research has supported the use of suspension devices in rehabilitation procedures both in practice and in theory. Although a longitudinal study has reported on the use of suspension devices among asymptomatic subjects, it is necessary to investigate the immediate effects of suspension exercises in patients with CLBP.

Objective: The present study aims to investigate changes in neuromuscular activation after the prescription of suspension exercises in patients with CLBP. Read More

View Article
November 2018

A review of the role of epidural percutaneous neuroplasty.

Pain Manag 2018 Dec 3. Epub 2018 Dec 3.

Vice Chair for Research & Education, Department of Anesthesiology & Pain Management, Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USA.

Degeneration, whether from age or postsurgical, in the ventral and lateral epidural space can lead to irritation of both the nerve roots and of the nerves present in the epidural space, the peridural membrane and the posterior longitudinal ligament. This irritation is often accompanied by mild scarring. Neuroplasty is a specific procedure designed to relieve this irritation. Read More

View Article
December 2018

Intervertebral disc herniation in elite athletes.

Int Orthop 2018 Dec 1. Epub 2018 Dec 1.

Department of Orthopaedic Surgery, Northwestern University, Feinberg School of Medicine, 676 North St. Clair Street, NMH/Arkes Family Pavilion Suite 1350, Chicago, IL, 60611, USA.

Intervertebral disc herniations are a common cause of neck and back pain in athletes. It is thought to be more prevalent in athletes than in the general population due to the consistent pressure placed on the spine and concurrent microtraumas that are unable to heal. Prevention focuses on neck and trunk stability and flexibility, training on proper technique, and rule changes to minimize catastrophic injuries. Read More

View Article
December 2018

Therapy of moderate-to-severe Graves' orbitopathy with intravenous methylprednisolone pulses is not associated with loss of bone mineral density.

Endocrine 2018 Dec 1. Epub 2018 Dec 1.

Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland.

Purpose: To evaluate the influence of intravenous methylprednisolone (IVMP) pulse administration on bone mineral density (BMD) of the lumbar spine and the femoral neck in patients with moderate-to-severe Graves' orbitopathy (GO).

Methods: Thirty-five patients with GO in euthyreosis were treated with 12 IVMP pulses (6 × 0.5 g, 6 × 0. Read More

View Article
December 2018

A TRAF6 genetic variant is associated with low bone mineral density in rheumatoid arthritis.

Clin Rheumatol 2018 Dec 1. Epub 2018 Dec 1.

Laboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, Ibn Al Jazzar street, 4000, Sousse, Tunisia.

Objectives: This study was aimed to investigate the association of the single nucleotide polymorphism of tumor necrosis factor receptor associated factor 6 (TRAF6), rs540386, with low bone mineral density (BMD) among patients with rheumatoid arthritis (RA).

Methods: TRAF6 rs540386 genotyping was performed by mutagenically separated PCR in a cohort of 188 (23 men, 165 women, median age, 56.2 years) adult RA patients and 224 age and gender-matched controls. Read More

View Article
December 2018

Assessing the effects of long-term osteoporosis treatment by using conventional spine radiographs: results from a pilot study in a sub-cohort of a large randomized controlled trial.

Skeletal Radiol 2018 Dec 1. Epub 2018 Dec 1.

Department of Internal Medicine, Division of Endocrinology & Diabetology, Medical University of Graz, Auenbruggerpl. 15, 8036, Graz, Austria.

Objective: To evaluate the clinical applicability of a software tool developed to extract bone textural information from conventional lumbar spine radiographs, and to test it in a subset of postmenopausal women treated for osteoporosis with the fully human monoclonal antibody denosumab.

Methods: The software was developed based on the principles of a fractal model using pixel grey-level variations together with a specific machine-learning algorithm. The obtained dimensionless parameter, termed bone structure value (BSV), was then tested and compared to bone mineral density (BMD) in a sub-cohort of postmenopausal women with osteoporosis who were treated with the monoclonal antibody denosumab, within the framework of a large randomized controlled trial and its open-label extension phase. Read More

View Article
December 2018

Current concepts for lumbar disc herniation.

Int Orthop 2018 Nov 30. Epub 2018 Nov 30.

Orthopaedic and Traumatology Surgery Department (Pr Ch Court), AP-HP Paris, Bicêtre University Hospital, Paris-Sud University ORSAY, 78 Rue du Général Leclerc, 94275, Le Kremlin-Bicêtre, France.

Purpose: To present the pathophysiology, biology, clinical presentation, diagnosis, and current treatment options for lumbar disc herniation.

Methods: A thorough literature search was undertaken in PubMed and Google Scholar to summarize the current knowledge and future perspectives on lumbar disc herniation.

Results: Several changes in the biology of the intervertebral disc are thought to contribute to disc herniation; nevertheless, the exact inciting event leading to disc herniation is yet to be discovered. Read More

View Article
November 2018
1 Read

The relevance of high-intensity zones in degenerative disc disease.

Int Orthop 2018 Nov 30. Epub 2018 Nov 30.

Department of Orthopaedics and Traumatology, The University of Hong Kong, Queen Mary Hospital, 5/F Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China.

Purpose: The purpose of this study was to review the current understanding of high-intensity zones (HIZ) in the lumbar spine with particular attention to its imaging phenotype and clinical relevance.

Methods: A review was conducted of studies related to HIZ. Particular attention was made to imaging phenotypes and classification, and its relationship with discogenic low back pain (LBP). Read More

View Article
November 2018
1 Read

Traumatic lumbar hernia: clinical features and management.

Ann Surg Treat Res 2018 Dec 26;95(6):340-344. Epub 2018 Nov 26.

Department of Trauma, Gachon University Gil Medical Center, Incheon, Korea.

Purpose: Traumatic lumbar hernia is rare, thus making diagnosis and proper treatment challenging. Accordingly, we aimed to investigate the clinical manifestations and proper management strategies of traumatic lumbar hernias.

Methods: The medical records of patients with traumatic lumbar hernia treated at Gachon University Gil Hospital from March 2006 to February 2015, were retrospectively reviewed. Read More

View Article
December 2018
1 Read

The modified transforaminal endoscopic technique in treating intracanalicular combining foraminal and/or extraforaminal lumbar disc herniations.

Quant Imaging Med Surg 2018 Oct;8(9):936-945

Department of Orthopedics, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.

Background: To develop a modified transforaminal endoscopic spine system (TESSYS) technique for treating intracanalicular combining foraminal and/or extraforaminal lumbar disc herniation (ICFE-LDH), and evaluate the technical efficacy and safety.

Methods: Twenty-three patients with ICFE-LDH underwent the modified TESSYS technique were enrolled. Magnetic resonance imaging (MRI) was used to verify the reduction of herniated disc. Read More

View Article
October 2018
1 Read

Unilateral Biportal Endoscopic Spinal Surgery Using a 30° Arthroscope for L5-S1 Foraminal Decompression.

Clin Orthop Surg 2018 Dec 21;10(4):508-512. Epub 2018 Nov 21.

Department of Spine Surgery, Barun Hospital, Jinju, Korea.

Foraminal decompression using a minimally invasive technique to preserve facet joint stability and function without fusion reportedly improves the radicular symptoms in approximately 80% of patients and is considered one of the good surgical treatment choices for lumbar foraminal or extraforaminal stenosis. However, proper decompression was not possible because of the inability to access the foramen at the L5-S1 level due to prominence of the iliac crest. To overcome this challenge, endoscopy-based minimally invasive spine surgery has recently gained attention. Read More

View Article
December 2018
1 Read

Clinical and Radiological Outcomes of Foraminal Decompression Using Unilateral Biportal Endoscopic Spine Surgery for Lumbar Foraminal Stenosis.

Clin Orthop Surg 2018 Dec 21;10(4):439-447. Epub 2018 Nov 21.

Department of Orthopedic Surgery, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.

Background: Since open Wiltse approach allows limited visualization for foraminal stenosis leading to an incomplete decompression, we report the short-term clinical and radiological results of unilateral biportal endoscopic foraminal decompression using 0° or 30° endoscopy with better visualization.

Methods: We examined 31 patients that underwent surgery for neurological symptoms due to lumbar foraminal stenosis which was refractory to 6 weeks of conservative treatment. All 31 patients underwent unilateral biportal endoscopic far-lateral decompression (UBEFLD). Read More

View Article
December 2018
1 Read

Aesthetic subunits of the trunk: Anatomy and behavior of skin and adipose tissue in each unit for better outcomes in liposuction.

Indian J Plast Surg 2018 May-Aug;51(2):115-122

Department of Plastic and Aesthetic Surgery, Venkat Center for Skin and Plastic Surgery, Bengaluru, Karnataka, India.

Background: Liposuction and abdominal contouring is one of the most common procedures performed by plastic surgeons worldwide. Surprisingly, there has been few attempts at dividing the abdomen into subunits to delineate and aid in this endeavour. We have evolved a system of abdominal aesthetic subunits which has enabled us to achieve high quality results. Read More

View Article
December 2018
1 Read

Herpes simplex encephalitis and pseudotumour cerebri due to ısotretinoin.

J Pak Med Assoc 2018 Dec;68(12):1833-11835

Department of Internal Medicine, Medical School, Firat University, Elazig Turkey.

Isotretinoin can have significant adverse reactions on multiple systems. We report a unique case of pseudotumour cerebri and herpes encephalitis resulting due to isotretinoin. A 19-year-old female patient was admitted to our clinic, presenting with headache, nausea, vomiting and fever since three days. Read More

View Article
December 2018
1 Read

Comparison of Minimally Invasive and Open Transforaminal Lumbar Interbody Fusion for Lumbar Disc Herniation: A Retrospective Cohort Study.

Med Sci Monit 2018 Dec 1;24:8693-8698. Epub 2018 Dec 1.

Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (mainland).

BACKGROUND This cohort study compared the efficacy and safety of minimally invasive versus open transforaminal lumbar interbody fusion (Mis-TLIF versus Open-TLIF) for lumbar disc herniation with radiculopathy. MATERIAL AND METHODS From July 2016 to September 2017, we recruited 37 patients suffering from lumbar disc herniation with radiculopathy. Seventeen patients underwent Mis-TLIF (Mis group) and 20 patients underwent Open-TLIF (Open group). Read More

View Article
December 2018

Patient-specific interactive software module for virtual preoperative planning and visualization of pedicle screw entry point and trajectories in spine surgery.

Neurol India 2018 Nov-Dec;66(6):1766-1770

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Lumbar pedicle screw insertion involves a steep learning curve for novice spine surgeons and requires image guidance or navigation. Small volume centers may be handicapped by the lack of cost-effective user-friendly tools for preoperative planning, guidance, and decision making.

Objective: We describe a patient-specific interactive software module, pedicle screw simulator (PSS), for virtual preoperative planning to determine the entry point and visualize the trajectories of pedicle screws. Read More

View Article
December 2018

PREDICTION OF MECHANICAL COMPLICATIONS IN ADULT SPINAL DEFORMITY SURGERY - THE GAP SCORE VERSUS THE SCHWAB CLASSIFICATION.

Spine J 2018 Nov 29. Epub 2018 Nov 29.

Department of Orthopedic Surgery, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address:

Background Context: - Surgery for adult spinal deformity (ASD) is a challenging and complex procedure with high reported complication (8.4-42%) and revision rates (9-17.6%). Read More

View Article
November 2018
1 Read

A Three-Dimensional Finite Element Analysis of Adjacent Segment Disc Degeneration Induced by Transforaminal Lumbar Interbody Fusion Following Pedicle Screw Fixation.

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Department of Orthopedics, Xianyang Central Hospital, Xianyang 712000, P.R. China. Electronic address:

Background: Transforaminal lumbar interbody fusion (TLIF) is an effective treatment of upper lumbar intervertebral disc herniation. However, its clinical efficacy for adjacent segment disc degeneration (ASDD) remains undefined. Therefore, the biomechanical evaluation of ASDD caused by TLIF after pedicle screw fixation (PSF) was explored via a three-dimensional (3D) finite element analysis. Read More

View Article
November 2018

Effect of age and sex on lumbar lordosis and the range of motion. A systematic review and meta-analysis.

J Biomech 2018 Nov 17. Epub 2018 Nov 17.

Julius Wolff Institut, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany. Electronic address:

Lumbar lordosis (LL) and the range of motion (RoM) are important physiological measurements when initiating any diagnosis and treatment plan for patients with low back pain. Numerous studies reported differences in LL and the RoM due to age and sex. However, these findings remain contradictory. Read More

View Article
November 2018
1 Read

Involvement of central nervous system in adult patients with acute myeloid leukemia: Incidence and impact on outcome.

Semin Hematol 2018 Oct 21;55(4):209-214. Epub 2018 Feb 21.

Hematology, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.

Incidence and effect on outcome of central nervous system (CNS) involvement in adult patients with acute myeloid leukemia (AML) is not clearly defined. To address this issue, 103 consecutive adult patients with newly diagnosed AML, regardless of neurologic symptoms, were submitted to a routine explorative lumbar puncture. Cerebrospinal fluid (CSF) samples were collected from 65 males and 38 females. Read More

View Article
October 2018

Low bone mineral density is associated with an elevated risk of developing increased arterial stiffness: A 10-year follow-up of Japanese women from the Japanese Population-based Osteoporosis (JPOS) cohort study.

Maturitas 2019 Jan 11;119:39-45. Epub 2018 Nov 11.

Department of Public Health, Kindai University Faculty of Medicine, 377-2 Oonohigashi, Osaka-Sayama, Osaka, 589-8511, Japan. Electronic address:

Objective: Only a few longitudinal studies have assessed the relationship between bone mineral density (BMD) and arteriosclerosis. This study aimed to determine whether low BMD at baseline is associated with the development of increased arterial stiffness, as evaluated by brachial-ankle pulse wave velocity (baPWV), in Japanese women.

Methods: A baPWV value of ≥1800 cm/s was adopted as the criterion for increased arterial stiffness, i. Read More

View Article
January 2019

Impact of bedside diagnosis of influenza in the paediatric emergency ward.

Clin Microbiol Infect 2018 Nov 28. Epub 2018 Nov 28.

Groupe Immunité des Muqueuses et Agents Pathogènes (GIMAP), EA3064, Faculty of Medicine of Saint-Etienne, University of Lyon, France; Laboratory of Infectious agents and Hygiene, University Hospital of Saint-Etienne, France.

Objectives: This prospective study performed in the paediatric emergency department of the University Hospital of Saint-Etienne aimed to measure the impact of the 24/7 bedside use of the Veritor™ System (Becton Dickinson) on the reduction of supplementary investigations, hospital stay and antimicrobial use.

Methods: Influenzavirus A and B antigens were detected with a rapid influenza digital immunoassay (DIA) on nasopharyngeal aspirates (NPA) sampled from the children consulting at the paediatric emergency department between January and March 2016 for influenza-like illness. The same NPA was tested by immunofluorescence and/or molecular routine assays. Read More

View Article
November 2018
1 Read

Type 2 endoleak incidence and fate after EVAR in a multicentric series: different results with different devices?

Ann Vasc Surg 2018 Nov 28. Epub 2018 Nov 28.

Vascular and Endovascular Surgery Unit, Deprtment of Surgery "P Stefanini", Policlinico "Umberto I", "Sapienza" University of Rome.

Objectives: Aim of this work is describing incidence and fate of type 2 endoleaks (T2EL) in a multi-centric cohort of patients treated by EVAR with Ovation device (Endologix), and compering them with a group treated by Excluder (W.L. Gore & Associates). Read More

View Article
November 2018

Evaluating the possible association between systemic osteoporosis and periodontal disease progression in postmenopausal women.

Dis Mon 2018 Nov 27. Epub 2018 Nov 27.

Department of Conservative Dental Sciences, Division of Endodontics, College of Dentistry, Prince Sattam bin Abdulaziz University, P.O. Box:153, AlKharj 11942 Riyadh, Saudi Arabia.

To evaluate the association between systemic osteoporosis and periodontal diseases in postmenopausal women. A total of 300 women aged (50-70 years) were divided into an osteoporotic (OP) group (n = 150) and non-osteoporotic (NOP) group (n = 150) depending on BMD measured using (DXA) at the femoral neck and lumbar spine. Periodontal examination including PI, GI, PPD, and CAL was measured. Read More

View Article
November 2018

Cerebrospinal fluid biomarkers of neurofibrillary tangles and synaptic dysfunction are associated with longitudinal decline in white matter connectivity: A multi-resolution graph analysis.

Neuroimage Clin 2018 Oct 23. Epub 2018 Oct 23.

Department of Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, WI, USA; Department of Computer Science, University of Wisconsin - Madison, Madison, WI, USA.

In addition to the development of beta amyloid plaques and neurofibrillary tangles, Alzheimer's disease (AD) involves the loss of connecting structures including degeneration of myelinated axons and synaptic connections. However, the extent to which white matter tracts change longitudinally, particularly in the asymptomatic, preclinical stage of AD, remains poorly characterized. In this study we used a novel graph wavelet algorithm to determine the extent to which microstructural brain changes evolve in concert with the development of AD neuropathology as observed using CSF biomarkers. Read More

View Article
October 2018