1,654,332 results match your criteria Lower Limb Orthotics


[The Rezūm system in the treatment of male lower urinary tract symptoms (LUTSs) due to benign prostatic obstruction (BPO)].

Aktuelle Urol 2018 Dec 6;49(6):519-524. Epub 2018 Dec 6.

Spital Thurgau AG, Urologie, Frauenfeld.

The classical algorithm of the management of male lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) includes a surgical approach in case pharmacological therapy has failed. Emerging minimally-invasive treatments (MITs) offer potential for rapid symptomatic relief, reducing the morbidity of invasive BPH surgery. Convective interstitial radiofrequency water vapour thermal ablation of the prostate with the Rezūm system is a novel MIT for the treatment of bothersome moderate-to-severe lower urinary tract symptoms associated with BPH. Read More

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December 2018
8 Reads

Impact of Hybrid Therapy Comprising Peritoneal Dialysis and Hemodialysis on Acute Cardiovascular Events.

Blood Purif 2018 Dec 6:1-7. Epub 2018 Dec 6.

Background: The impact of hybrid therapy comprising peritoneal dialysis (PD) and hemodialysis on cardiovascular events in PD patients remains unclear.

Objective: We aimed to evaluate the effect of hybrid therapy on cardiovascular events.

Methods: A total of 93 PD patients undergoing hybrid therapy for ≥3 years were divided into 2 groups according to left ventricular ejection fraction (LVEF): lower ejection fraction (LEF [n = 29], LVEF < 60%) and normal ejection fraction (NEF [n = 64], LVEF ≥60%). Read More

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December 2018
2 Reads

miR-122 Targets X-Linked Inhibitor of Apoptosis Protein to Sensitize Oxaliplatin-Resistant Colorectal Cancer Cells to Oxaliplatin-Mediated Cytotoxicity.

Cell Physiol Biochem 2018 Dec 6;51(5):2148-2159. Epub 2018 Dec 6.

Minimally Invasive Treatment Center, Fudan University Shanghai Cancer Center, Shanghai,

Background/aims: Although oxaliplatin is one of the most effective chemotherapeutic drugs used to treat colorectal cancer (CRC), long-term administration usually induces acquired drug resistance during the course of treatment. Thus, there is an urgent need to explore novel strategies to improve the efficiency of cancer therapy. The aim of this study was to explore the effect of microRNA-122 (miR-122) on reversing oxaliplatin resistance in CRC. Read More

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December 2018
2 Reads

Down-Regulation of Laminin (LN)- α5 is Associated with Preeclampsia and Impairs Trophoblast Cell Viability and Invasiveness Through PI3K Signaling Pathway.

Cell Physiol Biochem 2018 Dec 6;51(5):2030-2040. Epub 2018 Dec 6.

Department of Obstetrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing,

Background/aims: Preeclampsia (PE) is a gestational disorder defined as hypertension and proteinuria, which is deemed a major cause of maternal and neonatal mortality and morbidity worldwide. The aim of this study was to investigate the expression patterns of placental laminin (LN)-α5 expression in normal and PE pregnancies, as well as evaluating the effects of LN-α5 on trophoblast proliferation, apoptosis, and invasion.

Methods: LN-α5 expression levels were examined by reverse-transcriptase polymerase chain reaction (RT-PCR), and further confirmed by western blotting and immunofluorescence staining. Read More

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December 2018
2 Reads

Usual Interstitial Pneumonia Pattern in the Lower Lung Lobes as a Prognostic Factor in Idiopathic Pleuroparenchymal Fibroelastosis.

Respiration 2018 Dec 6:1-10. Epub 2018 Dec 6.

Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Background: Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare interstitial pneumonia that is characterized by stiffness in both the upper lobes and pleura, which is evident on high resolution computed tomography (HRCT) of the chest. However, prognostic factors for IPPFE have not been identified yet.

Objective: We aimed to investigate the clinical prognostic factors affecting survival in patients with IPPFE. Read More

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December 2018
5 Reads

Behavioral problems are associated with cognitive and language scores in toddlers born extremely preterm.

Early Hum Dev 2018 Dec 3;128:48-54. Epub 2018 Dec 3.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Objective: To evaluate the relationship of parent-reported child behaviors on the Child Behavior Checklist (CBCL) to cognition, language, and motor skills on the Bayley Scales of Infant and Toddler Development - III (Bayley-III) in toddlers born extremely preterm.

Study Design: Toddlers born extremely preterm (gestational ages 22 0/7 to 26 6/7 weeks) were tested at 22-26 months corrected age with Bayley-III while parents completed the CBCL. Socio-demographic variables and medical history were recorded. Read More

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December 2018
3 Reads

A giant sacrococcygeal teratoma in adult female: A case report.

Int J Surg Case Rep 2018 Nov 22;54:47-50. Epub 2018 Nov 22.

Department of General Surgery, King Abdulla University Hospital, Faculty of Medicine, Jordan University of Science and Technology, P.O. Box (3030), Irbid, 22110, Jordan. Electronic address:

Introduction: Sacrococcygealteratoma is very rare in adults with only few cases reported in literature. It is a slow growing benign cystic tumor with 1-2% chance for malignant transformation and may attain a huge size causing pressure effect on pelvic and intra-abdominal organs. When grows caudally, it causes discomfort, skin excoriation and cosmetic disfigurement. Read More

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November 2018
3 Reads

Socioeconomic differences among resident, users and neighbour populations of a protected area in the Brazilian dry forest.

J Environ Manage 2018 Dec 3;232:607-614. Epub 2018 Dec 3.

Departamento de Biociências, Universidade Federal Rural do Semiárido, Av. Francisco Mota, 572, Mossoró, Rio Grande do Norte, Brazil. Electronic address:

Protected areas are an important strategy to safeguard biodiversity. However, if social development is not considered, biological conservation targets may not be achieved. In this empirical study, we assess the relationship between poverty and conservation goals in dry forests within a 62,000-ha Brazilian National Park (Caatinga biome). Read More

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December 2018
1 Read

Simultaneous analysis of acetylcarnitine, proline, hydroxyproline, citrulline, and arginine as potential plasma biomarkers to evaluate NSAIDs-induced gastric injury by liquid chromatography-tandem mass spectrometry.

J Pharm Biomed Anal 2018 Nov 24;165:101-111. Epub 2018 Nov 24.

School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea. Electronic address:

Although major adverse effects associated with nonsteroidal anti-inflammatory drugs (NSAIDs) are gastric injury, assessment of NSAIDs-induced gastrointestinal adverse effects is mostly dependent on endoscopy due to the lack of plasma biomarkers. Several amino acids associated with collagenase activity and gastric mucosal mass have been suggested as plasma biomarker candidates for gastric injury. Therefore, this study aimed to develop a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the plasma biomarker candidates, i. Read More

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November 2018
2 Reads

Patient readiness for hospital discharge and its relationship to discharge preparation and structural factors: A cross-sectional study.

Int J Nurs Stud 2018 Nov 19;90:13-20. Epub 2018 Nov 19.

Institute of Nursing Science, University of Basel, Bernoullistrasse 28, 4056 Basel, Switzerland; Inselspital Bern University Hospital, Nursing Research Unit, 3010 Bern, Switzerland.

Background: Nursing discharge preparation is vital to successful hospital-to-home transitions. However, despite a wealth of evidence on its effectiveness, little is known of the structure- and process-related factors that facilitate or impede its use in clinical practice. Specifically, the associations between unit size and type, leadership support, skill mix, staffing, nurse and patient characteristics, discharge teaching and patient readiness for discharge have rarely been studied. Read More

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November 2018
6 Reads

Seasonal occurrence and fate of chiral pharmaceuticals in different sewage treatment systems in Hong Kong: Mass balance, enantiomeric profiling, and risk assessment.

Water Res 2018 Nov 9;149:607-616. Epub 2018 Nov 9.

State Key Laboratory of Marine Pollution (SKLMP), Research Centre for the Oceans and Human Health, Shenzhen Key Laboratory for the Sustainable Use of Marine Biodiversity, City University of Hong Kong, Hong Kong, China; Department of Chemistry, City University of Hong Kong, Hong Kong, China. Electronic address:

Concern about the presence of chiral pharmaceuticals in the environment from wastewater discharge is mounting. In this work, the occurrence and fate of atenolol, metoprolol, venlafaxine, and chloramphenicol, including 10 different stereoisomers, were investigated in sewage and sludge from diverse treatment processes in 4 sewage treatment plants (STPs) in Hong Kong via 4 sampling campaigns over a period of 2 years. The average amounts of individual pharmaceuticals entering the STPs ranged from 4. Read More

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November 2018
2 Reads

Effect of a cauliflower (Brassica oleraceae var. Botrytis) leaf powder-enriched diet on performance, carcass and meat characteristics of growing rabbit.

Meat Sci 2018 Nov 19;149:134-140. Epub 2018 Nov 19.

School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.

The aim of this study was to investigate the effect of a cauliflower leaf powder (CLP)-enriched diet on the performance, quality and antioxidative potential of rabbit meat. No significant differences were found for live performance parameters between rabbits fed with standard (SD) and CLP diet. Dietary supplementation influenced the meat traits of rabbits: CLP meat showed significantly lower drip loss after 48 h, cooking loss, and a significantly higher lightness (L*) and redness (a*) values, vitamin A and vitamin E content, and oxidative stability, compared to SD meat. Read More

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November 2018
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The prevalence and prognostic value of myelin oligodendrocyte glycoprotein antibody in adult optic neuritis.

J Neurol Sci 2018 Nov 28;396:225-231. Epub 2018 Nov 28.

Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China. Electronic address:

Background And Objective: Adult demyelinating optic neuritis (ON) with positive myelin-oligodendrocyte glycoprotein antibody (MOG-Ab) has distinct clinical features. This study aimed to investigate the point prevalence, relationship with steroid dependency and prognosis value of MOG-Ab in adult ON.

Methods: Clinical data analysis was undertaken in adults with ON admitted between December 2014 and January 2016. Read More

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November 2018
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Viability-based quantification of antibiotic resistance genes and human fecal markers in wastewater effluent and receiving waters.

Sci Total Environ 2018 Nov 22;656:495-502. Epub 2018 Nov 22.

Department of Civil and Environmental Engineering, Rutgers, The State University of New Jersey, 500 Bartholomew Dr, Piscataway, NJ 08854, United States. Electronic address:

Antibiotic resistance is a public health issue with links to environmental sources of antibiotic resistance genes (ARGs). ARGs from nonviable sources may pose a hazard given the potential for transformation whereas ARGs in viable sources may proliferate during host growth or conjugation. In this study, ARGs in the effluent from three municipal wastewater treatment plants (WWTPs) and the receiving surface waters were investigated using a viability-based qPCR technique (vPCR) with propidium monoazide (PMA). Read More

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November 2018
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A 'Fingerprint' of locomotor maturation: Motor development descriptors, reference development bands and data-set.

Gait Posture 2018 Nov 29;68:232-237. Epub 2018 Nov 29.

Department of Electrical, Electronic and Information Engineering "Guglielmo Marconi", University of Bologna, Via del Risorgimento 2, 40136 Bologna, Italy.

Background: When aiming at studying and monitoring locomotor development in childhood, innovative indexes for the characterization of motor control performance and wearable technologies have highlighted the potential of significant advances. In particular, quantitative assessment of motor performance during natural walking (NW) and tandem walking (TW) has been proposed to highlight manifestations of motor automaticity and complexity, respectively.

Research Question: This work aims at providing a quantitative overview of metrics characterizing locomotor maturation in a typically developing population, by analysing NW and TW. Read More

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November 2018

Elaboration of a thermosensitive smart biomaterial: From synthesis to the ex vivo bioadhesion evaluation.

Colloids Surf B Biointerfaces 2018 Nov 30;175:91-97. Epub 2018 Nov 30.

CIRIMAT, Université de Toulouse 3 - Paul Sabatier, CNRS, Toulouse, France. Electronic address:

Alginate and chitosan are polysaccharides that are widely used in the biomedical field, especially as wound dressings. Controlled bioadhesion is an advanced functionality that offers the potential to reduce injuries due to the stripping-off of the biomaterial. Herein, we report the efficient grafting of poly-N(isopropylacryamide) (PNIPAM), a thermosensitive polymer that exhibits a lower critical solution temperature (LCST) at 32 °C on the alginate/chitosan polyelectrolyte complex (PEC) surface. Read More

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November 2018

Developing crash prediction models using parametric and nonparametric approaches for rural mountainous freeways: A case study on Wyoming Interstate 80.

Accid Anal Prev 2018 Dec 3;123:176-189. Epub 2018 Dec 3.

Department of Mathematics and Statistics, University of Wyoming, 1000 E University Ave, Laramie, WY 82071, USA. Electronic address:

Interstate 80 in Wyoming is one of the busiest freight corridors that is characterized with harsh winter conditions and challenging mountainous roadway sections. The fatality rates in Wyoming are always typically higher than the national level. The 402-mile I-80 corridor in Wyoming was selected by the USDOT FHWA for piloting connected vehicle technology to improve the safety and mobility of heavy trucks. Read More

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December 2018

The unique spatial-temporal treatment failure patterns of adjuvant gefitinib therapy: A post-hoc analysis of the ADJUVANT trial (CTONG 1104).

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

Introduction: Adjuvant gefitinib therapy prolonged disease-free survival (DFS) in patients with resected early-stage epidermal growth factor receptor (EGFR)-mutation positive non-small cell lung cancer (NSCLC) in the ADJUVANT study (CTONG 1104). However, treatment failure patterns after gefitinib therapy are less well characterized.

Methods: Overall, 222 stage N1-N2, EGFR-mutant NSCLC patients received gefitinib or vinorelbine plus cisplatin (VP) treatment. Read More

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December 2018
2 Reads

Methadone therapy modulate the dendritic cells of heroin addicts.

Int Immunopharmacol 2018 Dec 3;66:330-335. Epub 2018 Dec 3.

Traditional and Complementary Medicine Research Center (TCMRC), Arak University of Medical Sciences, Arak, Iran; Department of Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Electronic address:

Evidence from various studies suggests that narcotics abuse may exert adverse immunomodulatory effects on immune responses. The aim of this research was to understand the effects of detoxification with methadone on the percentage of dendritic cells (DCs) and expression of its markers in heroin addicts. In this study, myeloid DCs (CD11c) and plasmacytoid DCs (CD123) were examined in two groups. Read More

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December 2018
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Left Atrial Appendage Closure Device Implantation in Patients with Prior Intracranial Hemorrhage.

Heart Rhythm 2018 Nov 19. Epub 2018 Nov 19.

Section of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Background: The Watchman™ device (Boston Scientific, MN), used for left atrial appendage closure (LAAC) was approved for stroke prevention in patients with atrial fibrillation (AF) and an appropriate rationale to avoid long-term oral anticoagulation. Patients with AF and prior intracranial hemorrhage (ICH) were excluded from clinical trials due to perceived risks of peri-operative anticoagulation.

Objective: We studied the efficacy and safety of LAAC using Watchman™ in patients with AF and prior ICH. Read More

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November 2018

Exploring potential new galactomannan source of Retama reatam seeds for food, cosmetic and pharmaceuticals: Characterization and physical, emulsifying and antidiabetic properties.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Industrial Engineering, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, SA, Italy.

In this study, physicochemical, interfacial and emulsifying properties of Retama reatam and guar galactomannans were comparatively investigated. The results showed that Retama reatam galactomannan is mainly composed of total carbohydrates (95.52%) and lower protein contents (0. Read More

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December 2018

Ammonium persulphate induced synthesis of polymethyl methacrylate grafted sodium alginate composite films with high strength for food packaging.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, PR China; College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, PR China. Electronic address:

The graft copolymerization of methyl methacrylate (MMA) onto alginate was carried out in aqueous media by initiators of ammonium persulphate under a nitrogen gas atmosphere. Then, the grafting of PMMA chains onto the alginate backbone was confirmed through the study of Fourier transform infrared, X-ray diffraction, scanning electron microscopy and H nuclear magnetic resonance spectroscopy. At last, a thin and transparent polymethyl methacrylate grafted alginate film with high strength was obtained by the casting method. Read More

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December 2018
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Influence of arabic gum on in vitro starch digestibility and noodle-making quality of Segoami.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Food and Nutrition, Hanyang University, Seoul, 04763, Republic of Korea. Electronic address:

The effects of arabic gum on the quality attributes of rice noodles were characterized in terms of physical properties as well as in vitro starch digestibility. Segoami (high amylose rice) was used to develop rice noodle with low predicted glycemic index (pGI). First, the processing condition for Segoami noodle was investigated at different levels of water content (100%-175%) and steaming time (1-5 min). Read More

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December 2018
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Pilot-scale isolation and characterization of extracellular polymeric substances (EPS) from cell-free medium of Spirulina sp. LEB-18 cultures under outdoor conditions.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy, Federal University of Bahia, Salvador, Brazil.

This objective of this work was to monitor the EPS production during the growth of Spirulina sp. LEB-18, evaluate the productivity and to characterize the exopolymers obtained on pilot-scale under outdoor conditions. The production of crude EPS occurred in all phases of biomass growth and was approximately ten folds higher than that biomass concentration of Spirulina sp. Read More

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December 2018

Development of methotrexate loaded fucoidan/chitosan nanoparticles with anti-inflammatory potential and enhanced skin permeation.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

LAQV-REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Portugal, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

In this study, fucoidan/chitosan nanoparticles were developed for the topical delivery of methotrexate towards the treatment of skin-related inflammatory diseases. Based on the fucoidan/chitosan (F/C) weight ratio, three different nanoparticles (1F/1C; 3F/1C; 5F/1C) were produced and characterized. Methotrexate was loaded in these polymeric nanoparticles achieving a drug loading of ca. Read More

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December 2018
2 Reads

HOXA5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α MAPK pathway.

Gene 2018 Dec 3. Epub 2018 Dec 3.

Department of Traumatic Orthopedics, The Second Hospital Affiliated to Lanzhou University, Lanzhou City, Gansu Province 730000, China.

Osteosarcoma is the most common malignant bone tumor in children and adolescents. Aberrant expression of HOXA5 results in various diseases, including cancers. However, the specific function and molecular mechanism of HOXA5 in osteosarcoma is not fully understood. Read More

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December 2018
1 Read

Daily energy expenditure of males following alternative reproductive tactics: Solitary roamers spend more energy than group-living males.

Physiol Behav 2018 Dec 3. Epub 2018 Dec 3.

School of Animal, Plant & Environmental Sciences, University of the Witwatersrand, Private Bag 3, WITS, 2050 Johannesburg, South Africa; IPHC, UNISTRA, CNRS, 23 rue du Loess, 67200 Strasbourg, France.

In many species, males follow alternative reproductive tactics (ARTs), where one tactic (called bourgeois) has much higher reproductive success than alternative tactics followed by males with lower competitive ability. The extent to which ARTs differ in energetic costs is unknown, but it is important to understand the fitness payoffs of ARTs. We studied male African striped mice (Rhabdomys pumilio) which follow one of three ARTs: heavy bourgeois males defend harems of females and have 10 times higher reproductive success than smaller roamers, which have ten times higher reproductive success than philopatric males, which remain in their natal group and are the smallest males. Read More

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December 2018

5- lipoxygenase (ALOX5): genetic susceptibility to type 2 diabetes and vitamin D effects on monocytes.

J Steroid Biochem Mol Biol 2018 Dec 3. Epub 2018 Dec 3.

Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, Goethe University Hospital, Frankfurt am Main, Germany.

The arachidonate 5-lipoxygenase (ALOX5) pathway has been implicated in chronic inflammatory disease which may be influenced by vitamin D due to vitamin D response elements (VDRE). We investigated an ALOX5 polymorphism (rs4987105) in patients with type 2 diabetes (T2D) and the in vitro effects of calcitriol (1,25(OH)D) on ALOX5 metabolism in monocytes of T2D patients and healthy controls (HC). 533 T2D and 473 HC were genotyped for the rs4987105 polymorphism. Read More

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December 2018

Recombinant Staphylococcal Antigen-F (r-ScaF), a novel vaccine candidate against methicillin resistant Staphylococcus aureus infection: Potency and efficacy studies.

Microb Pathog 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Staphylococcus aureus is a human commensal and pathogen, its clinical importance is exacerbated by the spread of multi-drug resistant strains. The potential future failure of antibiotic therapy necessitates the development of novel control regimes, including new immunotherapeutic approaches. S. Read More

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December 2018

Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy.

J Mol Cell Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg, Kiel, Lübeck, Germany; Institute of Pharmacy, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany. Electronic address:

The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca, chronically enhanced sympathetic tone with changed β-adrenergic signaling leads to alterations of gene expression and remodeling. The CREB-regulated transcription coactivator 1 (CRTC1) is activated by cAMP and Ca. Read More

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December 2018
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Sex differences in stress reactivity after intranasal oxytocin in recreational cannabis users.

Pharmacol Biochem Behav 2018 Dec 3. Epub 2018 Dec 3.

New York State Psychiatric Institute, New York, NY, United States of America; Columbia University Medical Center, New York, NY, United States of America.

Cannabis is the most widely used illicit drugs and the changing legal, political and cultural climate will likely increase cannabis use further. One factor that may underlie the transition from recreational use to problematic use is stress. The hormone oxytocin (OXT) modulates stress and may have therapeutic efficacy for substance use disorders, but few studies have examined OXT in cannabis users. Read More

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December 2018
2 Reads

Design, synthesis and anti-tumor evaluation of novel steroidal glycoconjugate with furoxan derivatives.

Steroids 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address:

In this study, eighteen novel steroidal-furoxan derivatives with 3-glycosyl or 3-methoxy moiety (12a-c, 13a-c, 17a-c, 26a-c, 27a-c and 28a-c) were synthesized and their anti-proliferative activity was evaluated against eight drug-sensitive and three drug-resistant cancer cell lines HeLa, A2780, LNCaP, PC-3, MDA-MB-231, MCF-7, SW480, A549, MCF-7/ADR, A2780/CDDP and A2780/T. Most of them displayed significant anti-cancer potency in vitro with IC values at the nanomole level. Among them, 3-methoxy steroidal-furoxan hybrids expressed much better activity than that of 3-glycosyl substitute ones, while estrane and 5α-H-androstane scaffold were slightly more favorable to the improvement of anti-proliferative activity. Read More

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December 2018
3 Reads

Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain.

J Mol Biol 2018 Dec 3. Epub 2018 Dec 3.

Instituto Biofisika (UPV/EHU, CSIC) y Dpto. de Bioquímica y Biología Molecular, Facultad de Ciencia y Tecnología, Universidad del País Vasco, Barrio Sarriena S/N, 48490, Leioa, Spain. Electronic address:

Protein aggregate reactivation in metazoans is accomplished by the combined activity of Hsp70, Hsp40 and Hsp110 chaperones. Hsp110s support the refolding of aggregated polypeptides acting as specialized nucleotide exchange factors of Hsp70. We have studied how Apg2, one of the three human Hsp110s, regulates the activity of Hsc70 (HspA8), the constitutive Hsp70 in our cells. Read More

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December 2018

Economic cost of malaria at household in high and low transmission areas of central India.

Authors:
Mrigendra Singh

Acta Trop 2018 Dec 3. Epub 2018 Dec 3.

ICMR-National Institute of Malaria Research Field Unit Jablpur, Epidemiology, ICMR-NIRTH Campus, Nagpur Road, 482003, Jabalpur, Madhya Pradesh, India. Electronic address:

The cost burden of malaria at the household level, resulting from complex social, economic, and epidemiological factors, is enormous. This study was carried out to estimate the economic burden of malaria at the household level in low and high malaria transmission areas of central India. We conducted surveys with households in which at least one member had suffered from malaria in the three months preceding the survey. Read More

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December 2018
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Single layer colloid centrifugation technique improves motility, viability and chromatin integrity of ram spermatozoa after thawing.

Cryobiology 2018 Dec 3. Epub 2018 Dec 3.

Clinic for Reproduction and Large Animals, University of Ljubljana, Vet Faculty, Ljubljana, Slovenia.

The cell membrane of ram spermatozoa is more sensitive to the freezing process than in other species due to its composition. As a result, the quality and viability of frozen thawed ram spermatozoa are often poor, which together with the specific structure of the ewe's cervix are the main reasons for lower fertility in ewes after intracervical insemination. In the present study we investigated the effects of semen centrifugation through a single layer of a species-specific colloid (Androcoll-O) on post-thaw quality of ram spermatozoa. Read More

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December 2018
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