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Trans R Soc Trop Med Hyg 2022 Jun 24. Epub 2022 Jun 24.

Faculdade de Medicina da Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190 - Santa Efigênia, Belo Horizonte, Minas Gerais, 30130-100, Brazil.

Background: Sarcopenia is a common complication of cirrhosis and an important predictor of morbimortality. We aimed to determine the prevalence of sarcopenia and its associated factors in hepatosplenic schistosomiasis (HSS) as well as to evaluate whether muscle mass and function are associated with variceal upper gastrointestinal bleeding (VUGIB) and previous splenectomy in subjects without other liver diseases.

Methods: We conducted a cross-sectional study including adults with HSS who underwent clinical, biochemical, anthropometric, muscle strength and physical performance evaluations and were submitted to bioelectrical impedance analysis and abdominal ultrasound. Read More

Cureus 2022 May 19;14(5):e25137. Epub 2022 May 19.

Department of Gastroenterology and Hepatology, Rutgers University New Jersey Medical School, Newark, USA.

Background Irritable bowel syndrome (IBS) is a "brain-gut disorder" that lacks laboratory, radiologic, or physical exam findings. Colonoscopies are not routinely performed unless "red flag" symptoms, such as bleeding or abnormal weight loss, are present. Socio-demographics have been implicated as sources of potential disparities in appropriate care. Read More

Cureus 2022 May 21;14(5):e25188. Epub 2022 May 21.

Gastroenterology, Parkview Medical Center, Pueblo, USA.

Dieulafoy lesions are common dilated submucosal vessels that can present with gastrointestinal (GI) bleeding. These lesions are usually found in the stomach or esophagus and colonic Dieulafoy lesions are very rare. Clinical presentation can vary from mild non-threatening GI bleeding to massive and recurrent hemorrhage. Read More

Korean J Gastroenterol 2022 Jun;79(6):244-251

Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Uijeongbu, Korea.

Background/aims: Globally, the population aged 80 years or older is growing faster due to the rising life expectancy. Korea has already entered into an advanced aged society, and a post-aged society is expected in 2025. This study evaluated the patterns of gastrointestinal disease in the population aged 80 years or older during the recent decade in Korea. Read More

Pharmaceutics 2022 May 24;14(6). Epub 2022 May 24.

Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.

The direct oral anticoagulants (DOACs), dabigatran, rivaroxaban, apixaban, and edoxaban, are becoming the most commonly prescribed drugs for preventing ischemic stroke in patients with non-valvular atrial fibrillation (NVAF) and for the treatment and prevention of venous thromboembolism (VTE). Rivaroxaban was also recently approved for the treatment of patients with a recent acute coronary syndrome (ACS). Their use demonstrated to have a favorable risk-benefit profile, with significant reductions in stroke, intracranial hemorrhage, and mortality compared to warfarin, but with increased gastrointestinal bleeding. Read More

Int J Environ Res Public Health 2022 Jun 20;19(12). Epub 2022 Jun 20.

Department of Emergency Medicine, Chang Gung Memorial Hospital at Keelung, Keelung City 204, Taiwan.

The COVID-19 pandemic has affected emergency department (ED) usage. This study examines changes in the number of ED visits for gastrointestinal (GI) bleeding and nonemergency GI conditions, such as acute gastroenteritis (AGE) and constipation, before the pandemic and at the peak and slack periods of the pandemic in Taiwan. This retrospective observational study was conducted at a referral medical center in northern Taiwan. Read More

Pediatr Neonatol 2022 Jun 5. Epub 2022 Jun 5.

Division of Pediatric Gastroenterology, Department of Pediatrics, Taipei Medical University Shuang Ho Hospital. No.291, Zhongzheng Rd., Zhonghe District, New Taipei City, 23561, Taiwan. Electronic address:

ACG Case Rep J 2022 Jun 9;9(6):e00688. Epub 2022 Jun 9.

Division of Gastroenterology and Hepatology, Internal Medicine Department, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.

Kasabach-Merritt syndrome is a rare but life-threatening disease in which a rapidly growing vascular tumor induces localized intravascular coagulation, causing thrombocytopenia, microangiopathic hemolytic anemia, and consumption coagulopathy. It presents mainly in infants and young children. We present an adult with recurrent and severe lower gastrointestinal bleeding due to Kasabach-Merritt syndrome, treated successfully with sirolimus after multiple other failed interventions. Read More

J Gastroenterol Hepatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background And Study Aims: The diagnosis and treatment of gastrointestinal (GI) bleeding secondary to malignancy can be challenging. Endoscopy is the gold standard to diagnose and treat gastrointestinal bleeding but clinical characteristics and outcomes of patients with malignancy-related bleeding are not well understood. This study aims to look at clinical characteristics, endoscopic findings, safety and clinical outcomes of endoscopic interventions for GI malignancy-related bleeding. Read More

BMC Gastroenterol 2022 Jun 21;22(1):301. Epub 2022 Jun 21.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background/aim: The ABC score is a new pre-endoscopic scoring system that was recently developed to accurately predict one-month mortality in upper and lower gastrointestinal bleeding (GIB). We aim to validate this new score on a cohort of Lebanese patients treated in a tertiary care center and to compare it to currently existing scores.

Methods: Adult patients admitted to the American University of Beirut Medical Center (AUBMC) with overt GIB between January 2013 and August 2020 were included. Read More

Frontline Gastroenterol 2022 2;13(4):295-302. Epub 2021 Jul 2.

Paul L Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.

Background And Objective: Cirrhosis is the number one cause of non-cancer deaths among gastrointestinal diseases and is responsible for significant morbidity and healthcare utilisation. The objectives were to measure the 30-day readmissions rate following index hospitalisation, to determine the predictors of readmission, and to estimate the cost of 30-day readmission in patients with decompensated cirrhosis.

Methods: We performed a retrospective cohort study of patients with decompensated cirrhosis using 2014 Nationwide Readmission Database from January to November. Read More

Frontline Gastroenterol 2022 20;13(4):309-315. Epub 2021 Sep 20.

Department of Digestive Disorders, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.

Introduction: Chronic gastrointestinal obstruction can precipitate a constellation of symptoms including nausea, vomiting, abdominal distension and pain that negatively impact on health-related quality of life. Decompression via venting gastrostomy can offer symptomatic relief but safety and efficacy data are sparse. This study characterises the diverse venting percutaneous endoscopic gastrostomy (vPEG) cohort at our tertiary referral centre and defines the safety and efficacy of this procedure. Read More

Front Immunol 2022 3;13:840916. Epub 2022 Jun 3.

The Second Affiliated Hospital, Department of Digestive Internal Medicine, Hengyang Medical School, University of South China, Hengyang, China.

Introduction: Immune checkpoint inhibitors (ICIs) have now become the standard therapy for malignancies like non-small cell lung cancer and classical Hodgkin's lymphoma. ICIs are associated with unique immune-related adverse events (irAEs) caused by dysregulated immune activation. Treatment of lower gastrointestinal (GI) tract irAEs, such as colitis, is more common. Read More

Asian J Surg 2022 Jun 16. Epub 2022 Jun 16.

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. Electronic address:

J Crit Care 2022 Jun 14;71:154093. Epub 2022 Jun 14.

Toronto Western Hospital, Toronto, Ontario, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada; Department of Medicine (Respirology), University Health Network, Toronto, Canada. Electronic address:

Purpose: Neurocritical care patients are at risk of stress-induced gastrointestinal ulceration. We performed a systematic review and meta-analysis of stress ulcer prophylaxis (SUP) in critically ill adults admitted with a primary neurologic injury.

Materials And Methods: We included randomized controlled trials (RCTs) comparing SUP with histamine-2-receptor antagonists (H2RAs) or proton pump inhibitors (PPIs) to placebo/no prophylaxis, as well as to each other. Read More

J Surg Case Rep 2022 Jun 14;2022(6):rjac278. Epub 2022 Jun 14.

Department of Surgery, Cavan General Hospital, Cavan, Ireland.

Lower gastrointestinal (GI) bleeding (LGIB) is a common surgical condition, which is frequently encountered in the emergency department. The most common origin of LGIB is from the colo-rectal region. However, in majority of cases where no apparent bleeding source is identified, small bowel is the area of concern. Read More

Wideochir Inne Tech Maloinwazyjne 2022 Jun 19;17(2):326-337. Epub 2022 Jan 19.

Department of General Surgery, TangDu Hospital, Fourth Military Medical University, Xi'an, Shannxi Province, China.

Introduction: Laparoscopic splenectomy and esophagogastric devascularization (LSED) is becoming increasingly popular in the treatment of esophageal-fundic variceal bleeding with portal hypertension (PHT) in China, and its high safety and minimal trauma have been proven. Fast-track (FT) surgery improves patient recovery and decreases postoperative complications.

Aim: To determine whether LSED with fast-track principles can provide better outcomes than traditional treatment for patients with PHT. Read More

J Pediatr Gastroenterol Nutr 2022 Jun 16. Epub 2022 Jun 16.

Hépatologie et Transplantation Hépatique Pédiatriques, Centre de référence de l'atrésie des voies biliaires et des cholestases génétiques, FSMR FILFOIE, ERN RARE LIVER, Hôpital Bicêtre, AP-HP, Université Paris-Saclay, Hépatinov, Inserm U 1193, Le Kremlin-Bicêtre, France and Radiologie pédiatrique, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.

Objectives: Primary prophylaxis of bleeding is debated in children with gastroesophageal varices; one of the reasons is the limited number of studies concerning its efficacy and safety. We report our experience with endoscopic primary prophylaxis.

Methods: From 2006 to 2019, 145 children (median age, 3. Read More

Anatol J Cardiol 2022 06;26(6):424-433

Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: The meta-analysis of randomized controlled trials has illustrated that the efficacy of low-dose non-vitamin K antagonist oral anticoagulants is inferior compared with standard-dose non-vitamin K antagonist oral anticoagulants, though they are still frequently prescribed for Asian patients with non-valvular atrial fibrillation. We aimed to further investigate the efficacy and safety of low-dose non-vitamin K antagonist oral anticoagulants by carrying out a meta-analysis of all relevant randomized controlled tri- als and cohort studies.

Methods: Cochrane Central Register of Controlled Trials, Embase, and MEDLINE were sys- tematically searched from the inception to September 9, 2021, for randomized controlled trials or cohorts that compared the efficacy and/or safety of low-dose non-vitamin K antagonist oral anticoagulants in Asian patients with non-valvular atrial fibrillation. Read More

Am J Transl Res 2022 15;14(5):3269-3277. Epub 2022 May 15.

Department of Cardiology, Hai'an People's Hospital, Jiangsu Province Hai'an 226600, Jiangsu Province, China.

Objective: To explore the effect of the whole-process health management model on the compliance of oral warfarin treatment in patients with non-valvular atrial fibrillation in primary hospitals.

Methods: We retrospectively analyzed the clinical data of 130 patients with non-valvular atrial fibrillation treated in the Department of Cardiovascular Medicine, Hai'an People's Hospital from January 2019 to December 2019. Among them, 63 patients who received routine continuing care were included in the control group, and 67 patients treated with whole-course health management model of primary hospitals were included in the observation group. Read More

J Vasc Surg 2022 Jun 11. Epub 2022 Jun 11.

Department of Surgery, University of North Carolina, Chapel Hill, NC. Electronic address:

Objective: Females with peripheral arterial disease (PAD) treated with endovascular interventions have increased limb-based procedural complications compared to males. Little is known regarding long-term bleeding risk in these patients who often require long-term antiplatelet or anticoagulation therapy. We hypothesize that females have a higher incidence of bleeding events compared to males in the year following endovascular intervention for PAD. Read More

Surg Endosc 2022 Jun 13. Epub 2022 Jun 13.

Department of Gastroenterology, Sherbrooke University Hospital, Sherbrooke, QC, Canada.

Background: Prophylactic coagulation after gastric endoscopic submucosal dissection (ESD) decreases the rate of delayed bleeding; however, it cannot prevent bleeding completely, and delayed bleeding may occur from non-exposed vessels that were not detected immediately after ESD or where prophylactic coagulation was inadequate. Doppler monitoring systems which can evaluate vascular flow have been recently introduced in the endoscopic field. We developed the Doppler probe method (DOP) using the novel system and conducted a comparative study. Read More

J Clin Biochem Nutr 2022 May 26;70(3):283-289. Epub 2021 Nov 26.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.

Transarterial embolization (TAE) is performed in patients with colonic diverticular bleeding after difficult endoscopic hemostasis or rebleeding. A total of 375 patients with hematochezia at our hospital from 1 April 2016 to 31 March 2020 were retrospectively analysed. Firstly, we compared the group in which hemostasis was achieved by endoscopy alone with the group that eventually underwent TAE. Read More

Int J Dev Neurosci 2022 Jun 10. Epub 2022 Jun 10.

Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, China.

Purpose: We summarized the clinical features of acute necrotizing encephalopathy (ANE) in children.

Methods: Clinical data of 14 children with ANE at one center from January 2017 to January 2020 were retrospectively analyzed. ANE severity score (ANE-ss) was used to assess ANE severity, and the Glasgow Outcome Scale-Extended was used to assess functional outcomes. Read More

Rev Esp Enferm Dig 2022 06 10;114. Epub 2022 Jun 10.

Aparato Digestivo, Hospital Universitario Marqués de Valdecilla.

Introduction: there is limited experience and understanding of massive nonvariceal gastrointestinal bleeding during therapy with direct-acting oral anticoagulants.

Objectives: to provide evidenced-based definitions and recommendations.

Methods: a consensus document developed by the Sociedad Española de Patología Digestiva using modified Delphi methodology. Read More

Sensors (Basel) 2022 May 27;22(11). Epub 2022 May 27.

College of Computer and Information Sciences, Prince Sultan University, Riyadh 11586, Saudi Arabia.

Every year, nearly two million people die as a result of gastrointestinal (GI) disorders. Lower gastrointestinal tract tumors are one of the leading causes of death worldwide. Thus, early detection of the type of tumor is of great importance in the survival of patients. Read More

J Clin Med 2022 Jun 4;11(11). Epub 2022 Jun 4.

Department of Nephrology and Dialysis, L. Parodi-Delfino Hospital, Piazza Aldo Moro 1, 00034 Rome, Italy.

Background: Direct oral anticoagulants (DOACs) are the preferred anticoagulant drugs for the prevention of atrial fibrillation (AF)-related thromboembolic complications and for the treatment and the prevention of recurrences of venous thromboembolism (VTE). The evaluation of self-reported adverse drug reactions (ADRs) available from databases of drug-regulatory agencies such as the Italian Medicines Agency (AIFA) pharmacovigilance database represents a novel aid to guide decision making.

Objective: To assess the safety profile of DOACs by analyzing ADR rates in the real-world Italian scenario. Read More

Diabetes Obes Metab 2022 Jun 8. Epub 2022 Jun 8.

Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Aims: Robust cost estimates are required to inform economic analysis of diabetes treatments. We estimate the annual hospital costs associated with a range of adverse events for people with diabetes in the UK.

Methods: Annual hospital costs (2019/20 GBP£) were derived from 15436 ASCEND participants between 2005 and 2017 (120,420 person-years). Read More

Transplant Proc 2022 Jun 5. Epub 2022 Jun 5.

Liver and Abdominal Organs Transplantation Division, Department of Gastroenterology, Hospital das Clínicas da Faculdade de Medicina de São Paulo; Laboratory of Medica Investigation 37 (LIM-37), Faculdade de Medicina da Universidade de São Paulo.

Background: Terlipressin is widely used for treatment of hepatorenal syndrome and variceal bleeding in cirrhotic patients. However, it may be associated with side effects, especially those related to vasoconstriction, such as myocardial infarction or intestinal ischemia. This is a case report of a cirrhotic patient with nonvariceal upper gastrointestinal bleeding after duodenal necrosis due to the use of terlipressin, a novel side effect not yet described in literature to the best of our knowledge. Read More

Aging Dis 2022 Jun 1;13(3):884-898. Epub 2022 Jun 1.

1Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

COVID-19 emerged in Wuhan in December 2019 and soon became a worldwide pandemic. We collected and analyzed the data from 1077 patients with COVID-19 who were admitted to the west campus of Wuhan Union Hospital from January 16 to April 16, 2020. Sixty (5. Read More