193,618 results match your criteria Lower GI Tract


Urogenital symptoms in mitochondrial disease: overlooked and undertreated.

Eur J Neurol 2019 Mar 18. Epub 2019 Mar 18.

MRC Centre for Neuromuscular Diseases, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.

Background: Bowel symptoms are well documented in mitochondrial disease. However, data concerning other pelvic organs is limited. We have undertaken a large, case-control study to determine the presence of lower urinary tract symptoms (LUTS) and sexual dysfunction in adults with genetically confirmed mitochondrial disease. Read More

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http://dx.doi.org/10.1111/ene.13952DOI Listing

Various addiction patterns, dietary habits, associated medical problems, and socioeconomic status in gastrointestinal malignancies: A prospective study in rural area of Maharashtra, India.

J Cancer Res Ther 2019 Jan-Mar;15(1):104-107

Department of Radiotherapy and Oncology, Rural Medical College, Pravara Institute of Medical Sciences, Ahmednagar, Maharashtra, India.

Background: Gastrointestinal (GI) malignancies are increasing with advancing age. Various addictions and poor dietary habits are among the major risk factors. Early detection is difficult until patient notices symptoms. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_925_17DOI Listing

SGL5213, a novel and potent intestinal SGLT1 inhibitor, suppresses intestinal glucose absorption and enhances plasma GLP-1 and GLP-2 secretion in rats.

Eur J Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan. Electronic address:

Sodium-glucose cotransporter 1 (SGLT1) is the primary transporter for glucose absorption from digested nutrients in the gastrointestinal tract. Intestinal SGLT1 inhibition reduces post-prandial hyperglycemia and enhances the increase of plasma glucagon-like peptide-1 (GLP-1) levels. SGL5213 is a novel and potent intestinal SGLT1 inhibitor. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.03.023DOI Listing

Potential Functions of the Gastrointestinal Microbiome Inhabiting the Length of the Rat Digest Tract.

Int J Mol Sci 2019 Mar 12;20(5). Epub 2019 Mar 12.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

The rat is an important model animal used frequently in biological researches exploring the correlations between gut microbiome and a wide array of diseases. In this study, we used an extended ancestral-state reconstruction algorithm to predict the functional capabilities of the rat gastrointestinal microbiome. Our results indicate an apparent tendency toward metabolic heterogeneity along the longitudinal and transverse axes of the rat gastrointestinal tract (GIT). Read More

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http://dx.doi.org/10.3390/ijms20051232DOI Listing

Toxicokinetic patterns, metabolites formation and distribution in various tissues of the Chinese rare minnow (Gobiocypris rarus) exposed to tri(2‑butoxyethyl) phosphate (TBOEP) and tri-n-butyl phosphate (TNBP).

Sci Total Environ 2019 Mar 6;668:806-814. Epub 2019 Mar 6.

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Alkylated organophosphate esters (alkyl-OPEs) are widely used and extensively detected in aquatic organisms. This work investigated the tissue-specific toxicokinetics of two common alkyl-OPEs, tri(2‑butoxyethyl) phosphate (TBOEP) and tri‑n‑butyl phosphate (TNBP) in Chinese rare minnow (Gobiocypris rarus) through a 50 day uptake and depuration experiment. The tissue-specific bioconcentration factor (BCF) values for the two alkyl-OPEs ranged from 1 to 30 L/kg wet weight (ww), with the kidney and ovary as the tissues with the highest accumulation. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.038DOI Listing

Different somatostatin and CXCR4 chemokine receptor expression in gastroenteropancreatic neuroendocrine neoplasms depending on their origin.

Sci Rep 2019 Mar 13;9(1):4339. Epub 2019 Mar 13.

Institute of Pharmacology and Toxicology, Jena University Hospital, Jena, Germany.

Somatostatin receptors (SST), especially SST2A, are known for their overexpression in well-differentiated gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). The chemokine receptor CXCR4, in contrast, is considered to be present mainly in highly proliferative and advanced tumors. However, comprehensive data are still lacking on potential differences in SST or CXCR4 expression pattern in GEP-NEN in dependence on the place of origin. Read More

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http://dx.doi.org/10.1038/s41598-019-39607-2DOI Listing

Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation.

Diagn Pathol 2019 Mar 13;14(1):22. Epub 2019 Mar 13.

Department of Radiology, Maisonneuve-Rosemont Hospital, 5415 Boulevard de L'Assomption, Montreal, QC, Canada.

Background: Malakoplakia is a chronic inflammatory disease characterized by tissue infiltrates of large granular macrophages containing distinctive intracytoplasmic inclusions termed Michaelis-Gutmann (MG) bodies. The genitourinary system is the most commonly involved site, followed by the gastrointestinal tract. Malakoplakia may occur as a complication of primary or secondary immunosuppression and, therefore, renal transplant recipients are at risk. Read More

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http://dx.doi.org/10.1186/s13000-019-0799-zDOI Listing
March 2019
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Comparison of Argon Plasma Coagulation and Injection Therapy with Adrenalin and Polidocanol in the Management of Bleeding Angiodysplasia in Upper Gastrointestinal Tract.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):63-68

University Children's Hospital, Medical Faculty Skopje, Republic of Macedonia.

Introduction: The term angiodysplasia (AD) refers to acquired malformation of the blood vessels (communications between veins and capillaries), frequently found within the gastrointestinal mucosa and submucosa. AD of stomach and duodenum are cause of upper gastrointestinal bleeding in 4%-7% of patients. The means of treatment are usually endoscopic, including argon plasma coagulation (APC), electrocoagulation, mechanical hemostasis by clippsing, laser photo-coagulation and injection therapy. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0043DOI Listing
December 2018

Effects on postoperative nausea and vomiting of nefopam versus fentanyl following bimaxillary orthognathic surgery: a prospective double-blind randomized controlled trial.

J Dent Anesth Pain Med 2019 Feb 28;19(1):55-66. Epub 2019 Feb 28.

Department of Dental Anesthesiology, School of Dentistry, Seoul National University, Seoul, Republic of Korea.

Background: Postoperative nausea and vomiting (PONV) frequently occurs following bimaxillary orthognathic surgeries. Compared to opioids, Nefopam is associated with lower incidences of PONV, and does not induce gastrointestinal tract injury, coagulopathy, nephrotoxicity, or fracture healing dysfunction, which are common side effects of Nonsteroidal anti-inflammatory drugs. We compared nefopam- and fentanyl-induced incidence of PONV in patients with access to patient-controlled analgesia (PCA) following bimaxillary orthognathic surgeries. Read More

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http://dx.doi.org/10.17245/jdapm.2019.19.1.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405349PMC
February 2019

Cystic brain metastases had slower speed of tumor shrinkage but similar prognosis compared with solid tumors that underwent radiosurgery treatment.

Cancer Manag Res 2019 20;11:1753-1763. Epub 2019 Feb 20.

Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China,

Purpose: Traditionally, radiosurgery was considered less effective for patients with cystic brain metastases. However, comparisons of prognosis between cystic and solid brain metastases in cancer patients have been seldom reported. We aimed to compare the survival between cystic and solid brain metastases and assess risk factors for overall survival after brain metastases (BMOS) in patients who underwent radiosurgery treatment. Read More

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http://dx.doi.org/10.2147/CMAR.S188674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387614PMC
February 2019

The plasmid-encoded pGP3 promotes evasion of acidic barriers in both stomach and vagina.

Infect Immun 2019 Mar 11. Epub 2019 Mar 11.

Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA

Although is a human genital tract pathogen, chlamydial organisms have been frequently detected in both vaginal and rectal swabs of animals and humans. The plasmid-encoded pGP3, a genital tract virulence factor, is essential for to colonize mouse gastrointestinal tract. However, intracolon inoculation to bypass the gastric barrier rescued the colonization of pGP3-deficient mutant, suggesting that pGP3 is required for to reach but not colonize the large intestine. Read More

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http://dx.doi.org/10.1128/IAI.00844-18DOI Listing

Diagnosis of chronic anaemia in gastrointestinal disorders: A guideline by the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) and the Italian Society of Paediatric Gastroenterology Hepatology and Nutrition (SIGENP).

Dig Liver Dis 2019 Feb 11. Epub 2019 Feb 11.

Oncological Gastroenterology Division, Centro di Riferimento Oncologico (CRO) IRCCS, Aviano.

Anaemia is a common pathologic condition, present in almost 5% of the adult population. Iron deficiency is the most common cause; other mechanisms can be involved, making anaemia a multi-factorial disorder in most cases. Anaemia being a frequent manifestation in the diseases of the gastrointestinal tract, patients are often referred to gastroenterologists. Read More

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http://dx.doi.org/10.1016/j.dld.2019.01.022DOI Listing
February 2019
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Characterizing the microbiota in gastrointestinal tract segments of Rhabdophis subminiatus: Dynamic changes and functional predictions.

Microbiologyopen 2019 Mar 7:e789. Epub 2019 Mar 7.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.

The gut microbiota helps the host to absorb nutrients and generate immune responses that can affect host behavior, development, reproduction, and overall health. However, in most of the previous studies, microbiota was sampled mainly using feces and intestinal contents from mammals but not from wild reptiles. Here, we described the bacterial profile from five different gastrointestinal tract (GIT) segments (esophagus, stomach, small intestine, large intestine, and cloaca) of three wild Rhabdophis subminiatus using 16S rRNA V4 hypervariable amplicon sequencing. Read More

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http://dx.doi.org/10.1002/mbo3.789DOI Listing

Pseudo to pseudo connection: pseudoaneurysm draining into the pseudocyst causing pseudohaemobillia.

BMJ Case Rep 2019 Mar 6;12(3). Epub 2019 Mar 6.

Department of Internal Medicine, Geisinger Medical Center, Danville, Pennsylvania, USA.

Haemosuccus pancreaticus (HP) is an exceedingly rare cause of lower gastrointestinal (GI) bleed where pseudoaneurysm of the peripancreatic vessels ruptures into a pancreatic pseudocyst and blood travel through the pancreatic duct, thereby, draining into GI tract via the ampulla of Vater. We present a case of 65-year-old African-American woman with a history of alcohol abuse presented with melena for 1 day. The contrast-enhanced CT of abdomen/pelvis showed peripancreatic vascular pseudoaneurysm with active haemorrhage. Read More

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http://dx.doi.org/10.1136/bcr-2018-228441DOI Listing
March 2019
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Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA).

Neurogastroenterol Motil 2019 Mar 5:e13580. Epub 2019 Mar 5.

Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Background: Bisphenol A (BPA) is commonly used in the production of plastics and has multidirectional, negative effects on the living organisms. It may also affect the enteric nervous system (ENS) located in the wall of the gastrointestinal tract. Enteric neurons express many active substances, which regulate majority of intestinal activities not only in physiological conditions but also under the impact of pathological factors. Read More

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http://dx.doi.org/10.1111/nmo.13580DOI Listing

Comparison of Positive Oral Contrast Agents for Abdominopelvic CT.

AJR Am J Roentgenol 2019 Mar 5:1-7. Epub 2019 Mar 5.

1 Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, Box 0628, M-372, San Francisco, CA 94143-0628.

Objective: The objective of our study was to compare the quality of bowel opacification from three different positive oral contrast agents-barium sulfate, diatrizoate, and iohexol-at abdominopelvic CT.

Materials And Methods: Abdominopelvic CT examinations with three different oral contrast agents (each contrast agent: n = 300 patients) of 900 patients were retrospectively evaluated by two independent readers. For four segments of the gastrointestinal tract (i. Read More

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http://dx.doi.org/10.2214/AJR.18.20445DOI Listing
March 2019
1 Read
2.731 Impact Factor

Novel genotype of infectious bronchitis virus isolated in China.

Vet Microbiol 2019 Mar 29;230:178-186. Epub 2019 Jan 29.

Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin 150001, People's Republic of China. Electronic address:

Recombination events are known to contribute to the emergence of novel infectious bronchitis virus (IBV) genotypes. In this study, we carried out detailed phylogenetic analysis and sequence comparisons based on 74 complete nucleotide sequences of the IBV S1 gene, including strain I0636/16 and 73 representative sequences from each genotype and lineage. The results showed that strain I0636/16 represented a novel genotype, designated as lineage 1 within genotype VII (GVII-1). Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.01.020DOI Listing
March 2019
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Phase I trial of concurrent stereotactic body radiotherapy and nelfinavir for locally advanced borderline or unresectable pancreatic adenocarcinoma.

Radiother Oncol 2019 Mar 20;132:55-62. Epub 2018 Dec 20.

Department of Internal Medicine, Division of Hematology Oncology, University of Nebraska Medical Center, Omaha, USA.

Introduction: The HIV protease inhibitor nelfinavir (NFV) displays notable radiosensitizing effects. There have been no studies evaluating combined stereotactic body radiotherapy (SBRT) and NFV for borderline/unresectable pancreatic cancer. The primary objective of this phase I trial (NCT01068327) was to determine the maximum tolerated SBRT/NFV dose, and secondarily evaluate outcomes. Read More

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http://dx.doi.org/10.1016/j.radonc.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400311PMC
March 2019
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The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases.

Nat Rev Gastroenterol Hepatol 2019 Mar 1. Epub 2019 Mar 1.

Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

The gut microbiota is a dense and diverse ecosystem that is involved in many physiological functions as well as in disease pathogenesis. It is dominated by bacteria, which have been extensively studied in the past 15 years; however, other microorganisms, such as fungi, phages, archaea and protists, are also present in the gut microbiota. Exploration of the fungal component, namely, the mycobiota, is at an early stage, and several specific technical challenges are associated with mycobiota analysis. Read More

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http://dx.doi.org/10.1038/s41575-019-0121-2DOI Listing
March 2019
12.610 Impact Factor

Cosmesis in Patients after Multiport Laparoscopic Colorectal Surgery: Does the Extraction Incision Matter?

Am Surg 2019 Feb;85(2):162-166

The ideal incision for specimen extraction during laparoscopic colorectal surgery is controversial. The objective of this study was to compare incision types (Pfannenstiel, periumbilical, lower midline, and right upper quadrant transverse) with regard to postoperative scar appearance, symptoms, preference, and satisfaction. This study is a retrospective survey review performed in an urban teaching hospital. Read More

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February 2019

Caution: Increased Acute Kidney Injury in Enhanced Recovery after Surgery (ERAS) Protocols.

Am Surg 2019 Feb;85(2):156-161

Minimizing perioperative fluid administration is a key component of enhanced recovery after surgery protocols (ERAS). Acute kidney injury (AKI) is a major cause of morbidity and mortality in hospitalized patients. Our aim was to assess the association of ERAS with the incidence and severity of AKI in patients undergoing elective colorectal surgery. Read More

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February 2019
2 Reads

The Cost of Surgical Site Infections after Colorectal Surgery in the United States from 2001 to 2012: A Longitudinal Analysis.

Am Surg 2019 Feb;85(2):142-149

Surgical site infections (SSIs) are among the most common types of postoperative complications in the United States and are associated with significant prevalence of morbidity and mortality in patients undergoing surgical interventions, especially in colorectal surgery (CRS) where SSI rates are significantly higher than those of similar operative sites. SSIs were identified from the National Inpatient Sample-Healthcare Cost and Utilization Project database from 2001 to 2012 based on the specification of an ICD-9 code. Propensity score matching was used to compare costs associated with SSI cases with those of non-SSI controls among elective and nonelective admissions. Read More

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February 2019

A single nucleotide polymorphism in dopamine beta hydroxylase (rs6271(C>T)) is over-represented in inflammatory bowel disease patients and reduces circulating enzyme.

PLoS One 2019 28;14(2):e0210175. Epub 2019 Feb 28.

Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania, United States of America.

Inflammatory bowel diseases (IBD) are associated with altered neuronal regulation of the gastrointestinal (GI) tract and release of norepinephrine (NE). As sympathetic innervation of the GI tract modulates motility, blood flow, and immune function, changes in NE signaling may alter the risk of developing IBD. Dopamine beta-hydroxylase (DβH), the enzyme responsible for NE production, has been suggested to play a critical role in IBD, however the exact mechanism is unknown. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210175PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394932PMC
February 2019
1 Read

Successful closure of ileostomy in a patient with intestinal Behçet's disease after therapy with adalimumab: A case report.

Medicine (Baltimore) 2019 Mar;98(9):e14624

Department of Rheumatology and Immunology.

Rationale: Behçet's disease (BD) is a chronic immune-mediated inflammatory disorder involving multiple organ systems. In BD, intestinal ulcers can present as a refractory lesion capable of perforation, which makes the choice of treatment difficult.

Patient Concerns: A 34-year-old male who was diagnosed with intestinal BD and suffered with an ileocecal perforation. Read More

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http://dx.doi.org/10.1097/MD.0000000000014624DOI Listing
March 2019
1 Read

Prognostic factors in patients with advanced extrahepatic cholangiocarcinoma: A single center experience.

Medicine (Baltimore) 2019 Feb;98(8):e14556

Department of Medical Oncology, Acibadem University School of Medicine, Istanbul, Turkey.

Extrahepatic cholangiocarcinoma (ECC) is an aggressive malignancy causing a lot of fatalities and comorbidities. Endoscopic biliary stenting (EBS) is mostly needed for ECC. In this study, we aimed to investigate the prognostic factors for the overall survival (OS) and the factors predicting the patients eligible for chemotherapy after EBS in ECC. Read More

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http://dx.doi.org/10.1097/MD.0000000000014556DOI Listing
February 2019
3 Reads

Fallback technique with circular stapler prevents anastomotic obstruction after esophagectomy: A case report of surgical approach.

Medicine (Baltimore) 2019 Feb;98(8):e13571

Department of Thoracic Surgery.

Rationale: While performing esophago-ileal anastomosis after esophagectomy with circular staplers, the mucosal folds of the ileum can complicate stapling and lead to obstruction, especially when the diameter of the circular stapler is equal or greater than that of the small bowel lumen.

Patient Concerns: A 53-year-old man, presented with complaints of difficulty in swallowing for 2 weeks. Fifteen years previously, he had undergone partial gastrectomy for gastric ulcers. Read More

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http://dx.doi.org/10.1097/MD.0000000000013571DOI Listing
February 2019
1 Read

Nutrient drink test: A promising new tool for irritable bowel syndrome diagnosis.

World J Gastroenterol 2019 Feb;25(7):837-847

Department of Digestive Diseases, Hospital Clinico San Carlos and Complutense University, Madrid 28040, Spain.

Background: Irritable bowel syndrome (IBS) is a highly prevalent condition. It is diagnosed on the basis of chronic symptoms after the clinical and/or investigative exclusion of organic diseases that can cause similar symptoms. There is no reproducible non-invasive test for the diagnosis of IBS, and this raises diagnostic uncertainty among physicians and hinders acceptance of the diagnosis by patients. Read More

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http://dx.doi.org/10.3748/wjg.v25.i7.837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385016PMC
February 2019
1 Read

Colono-protective Potentiality of Methanolic Bark Extract of Acacia catechu: A Medicinal Plant against 1,2-Dimethylhydrazine-Induced Toxicity in Wistar Rats.

J Environ Pathol Toxicol Oncol 2018 ;37(4):273-289

Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, School of Chemical and Life Sciences amia Hamdard, New Delhi, India.

The protective efficacy of methanolic bark extract of Acacia catechu Willd. (MEBA) against 1,2-dimethylhydrazine (DMH)-induced colon toxicity was investigated. Acacia catechu is considered one of the most potent medicines for various diseases in Ayurveda, a traditional system of Indian medicine. Read More

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http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2018026923DOI Listing

Radiotherapy for Hepatocellular Carcinoma Results in Comparable Survival to Radiofrequency Ablation: a Propensity Score Analysis.

Hepatology 2019 Feb 25. Epub 2019 Feb 25.

Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.

Potentially curative treatments for early-stage hepatocellular carcinoma (HCC) have each drawbacks and contraindications. Recently, radiotherapy can achieve good outcomes. We compared the outcomes of radiotherapy and radiofrequency ablation (RFA) for early-stage HCC. Read More

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http://dx.doi.org/10.1002/hep.30591DOI Listing
February 2019

Crohn's Disease Complicated with Extensive Thrombosis of Limbs and Mesenteric Arteries: A Case report and literature review.

Ann Vasc Surg 2019 Feb 22. Epub 2019 Feb 22.

Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao City 266003, Shandong Province, China.

Introduction: Crohn's disease (CD) is a chronic disease characterized by purulent inflammation involving any part of the gastrointestinal tract between the oral cavity and the anus. Although studies have reported various complications of CD, arterial thrombosis is extremely rare in these patients. We report a patient with CD presenting with extensive thrombosis of the extremities and mesenteric arteries. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.12.079DOI Listing
February 2019
3 Reads

[Survival comparison of Siewert II adenocarcinoma of esophagogastric junction between transthoracic and transabdominal approaches:a joint data analysis of thoracic and gastrointestinal surgery].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Feb;22(2):132-142

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041,China, Email:

Objective: To compare the long-term survival outcomes of Siewert II adenocarcinoma of esophagogastric junction (AEG) between transthoracic (TT) approach and transabdominal (TA) approach.

Methods: The databases of Gastrointestinal Surgery Department and Thoracic Surgery Department in West China Hospital of Sichuan University from 2006 to 2014 were integrated. Patients of Siewert II AEG who underwent resection were retrospectively collected. Read More

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February 2019
2 Reads

Optimizing Vitamin and Trace Element Profiles in Blood after Gastrointestinal Tract Surgery by a New Parenteral Nutrition Formula.

Ann Nutr Metab 2019 Feb 22;74(3):189-199. Epub 2019 Feb 22.

Research and Development Center, Otsuka Pharmaceutical Factory Inc., Tokyo, Japan.

Introduction: Though micronutrient formulations for parenteral nutrition (PN) have been revised, the impacts of these changes on nutritional parameters, blood micronutrient levels, and safety have yet to be clarified. We examined the efficacy and safety of a new PN formulation with a micronutrient composition based on the Food and Drug Administration 2000 recommendation in surgical patients.

Methods: This phase III clinical trial (JapicCTI-No. Read More

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http://dx.doi.org/10.1159/000497227DOI Listing
February 2019

A quantitative exploration of gastrointestinal bleeding in intensive care unit patients.

PLoS One 2019 22;14(2):e0212040. Epub 2019 Feb 22.

Department of Medicine, Columbia University Medical Center, New York, NY, United States of America.

Background: Quantitative assessments of the severity of bleeding in patients with bleeds within the gastrointestinal tract (GIB) are generally limited to blood tests like the hematocrit. The varied and irregular nature of the data collected during such observations makes it difficult in retrospective data analysis to characterize the complete course of bleeding. We intend to quantify the rate of blood loss over the course of an ICU stay, facilitating more precise analysis of retrospective data, and to use this quantification to examine questions about the effects of GIB. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212040PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386222PMC
February 2019
1 Read

Endoscopic Ultrasound-Guided Tissue Acquisition Using Fork-Tip Needle Improves Histological Yield, Reduces Needle Passes, Without On-Site Cytopathological Evaluation.

J Pancreat Cancer 2018 31;4(1):75-80. Epub 2018 Oct 31.

Division of Gastroenterology, Department of Internal Medicine, Kaiser Permanente Fontana Medical Center, Fontana, California.

Endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) and fine needle aspiration (FNA) are established methods in tissue acquisition. A new fork-tip FNB needle has been used to obtain core tissue samples. We compared the performance of the FNB using fork-tip needles with that of the FNA using conventional needles in patients who had solid neoplastic lesions within and around the upper gastrointestinal (GI) tract. Read More

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http://dx.doi.org/10.1089/pancan.2018.0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371597PMC
October 2018

[Changes of intestinal mucosal barrier function and effects of early enteral nutrition in patients with severe organophosphorus poisoning].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):442-446

Intensive Care Unit, Bozhou People's Hospital Affiliated to Anhui University of Science and Technology, Bozhou 236800, China.

To observe the changes of intestinal barrier function in patients with acute severe organophosphorus pesticide poisoning (ASOPP) and the effect of early enteral nutrition on them. A single-center, single-sample, prospective, randomized controlled clinical trial was conducted. A total of 50 patients with ASOPP were divided into 24 h enteral nutrition group (group A) and 48 h (48-72 h) enteral nutrition group (B group) according to the order of hospitalization. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.012DOI Listing
February 2019
1 Read

Pseudoxanthomatous or xanthelasmoid mastocytosis: Reporting a rare entity.

Indian J Dermatol Venereol Leprol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

Mastocytosis is a disease characterized by abnormal and pathologic increase in mast cells in the cutaneous tissue and extracutaneous organs such as the bone marrow, liver, spleen, lymph node and gastrointestinal tract. Cutaneous mastocytosis comprises of four major clinical variants: solitary and multiple mastocytomas, urticaria pigmentosa, diffuse cutaneous mastocytosis and telangiectasia macularis eruptiva perstans. Cutaneous mastocytosis of the xanthelasmoid type is a rare variant of diffuse mastocytosis. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_633_17DOI Listing
February 2019

Anal tear in a girl due to the penetration of a dog's penis. Unusual case report.

J Forensic Leg Med 2019 Feb 6;62:112-114. Epub 2019 Feb 6.

Facultad de Medicina, Universidad de la República, Uruguay.

We present the case of a six year and two months old girl who showed a large anal tear, attributed to the penetration of pet dog's penis. After several interviews with the child, as well as her parents, the paediatric psychiatrist assessed the account of events as authentic, understanding by that her narration of events approaches to the subject's truth. According with the guidelines the patient was discharged home with strict follow up by her paediatrician. Read More

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http://dx.doi.org/10.1016/j.jflm.2019.02.001DOI Listing
February 2019
6 Reads

Optimum colonoscopy withdrawal: Is time everything?

Gastrointest Endosc 2019 03;89(3):531-532

Wolfson Unit for Endoscopy, St Mark's Hospital, Harrow, United Kingdom.

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http://dx.doi.org/10.1016/j.gie.2018.10.045DOI Listing

Ensuring that endoscopists completely clear the colon of adenomas: Perhaps we try more carrots?

Gastrointest Endosc 2019 03;89(3):503-505

Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Department of Medicine, Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1016/j.gie.2018.09.023DOI Listing

AAV-Mediated Gene Delivery to the Enteric Nervous System by Intracolonic Injection.

Methods Mol Biol 2019 ;1950:407-415

Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.

The enteric nervous system of the lower gastrointestinal tract comprises intrinsic neural circuits as well as extrinsic afferent and efferent innervation. The development of strategies for neuronal gene transfer has created new opportunities for functional analysis, circuit mapping, and neuromodulation in the enteric nervous system. Studies of AAV-mediated gene transfer to enteric neurons and dorsal root ganglion neurons (DRG) have provided proofs-of-concept for the utility of AAV vectors for genetic manipulations of the intrinsic and extrinsic components of the enteric nervous system. Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_24DOI Listing
January 2019

Preoperative rectosigmoid endoscopic ultrasonography predicts the need for bowel resection in endometriosis.

World J Gastroenterol 2019 Feb;25(6):696-706

Department of Hepato-gastro-enterology, Centre Hospitalier Intercommunal Poissy Saint Germain, Poissy 78300, France.

Background: Rectosigmoid endometriosis is an underdiagnosed disease responsible for abdominal pain, transit disorders and rectal bleeding. Two surgical approaches, rectosigmoid bowel resection (segmental or patch) or intramuscular layer dissection (shaving), are available.

Aim: To assess whether the lesion features observed preoperative rectosigmoid endoscopic ultrasonography (RS-EUS) might predict the need for bowel resection. Read More

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http://dx.doi.org/10.3748/wjg.v25.i6.696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378538PMC
February 2019
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Eosinophilic Gastrointestinal Diseases in Childhood.

Ann Nutr Metab 2018 19;73 Suppl 4:18-28. Epub 2019 Feb 19.

Division on Gastroenterology, Hepatology and Nutrition, First Department of Pediatrics, University of Athens, Children's Hospital "Agia Sofia", Athens,

Eosinophilic gastrointestinal diseases (EGIDs) comprise a group of chronic, inflammatory diseases of the gastrointestinal (GI) tract, that are characterized, clinically, by symptoms related to the dysfunction of the involved segment(s) of the GI tract, and histologically, by dense eosinophilic inflammation, in the absence of an identifiable secondary cause. The group of EGIDs comprises eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC). EoE is the most common and the best described EGID compared to EG, EGE, and EC. Read More

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http://dx.doi.org/10.1159/000493668DOI Listing
February 2019
2 Reads

Determination of mechanisms of action of active carbons as a feed additive.

Bioorg Chem 2019 Feb 16. Epub 2019 Feb 16.

Department of Fuels Chemistry and Technology, Wroclaw University of Science and Technology, Gdanska 7/9, 50-344 Wroclaw, Poland. Electronic address:

Activated carbon's porous structure allows it to adsorb a substrates, products and catalysts from the environment thus modificated the biocatalysis processes in digestive tract. Active carbons are currently used to remove solvents from gas streams and for water purification; however, few studies have examined the mechanisms of action of active carbon during the biotransformation processes in the digestive tracks. The potential benefits of using activated carbon in feed are uncertain because both its chemical and physical properties can vary significantly depending on the type of carbonaceous feedstock. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.02.029DOI Listing
February 2019
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Improved gastrointestinal stability of solid lipid nanoparticles using comb-shaped amphiphilic inulin derivatives.

Pharmazie 2019 01;74(1):47-53

In order to reduce enzymatic degradation and thereby enhance the stability of solid lipid nanoparticles (SLNs) in the gastrointestinal tract, comb-shaped amphiphilic macromolecular material (CAM) of dodecyl inulin (Inu12) and octadecyl inulin (Inu18) were designed as the emulsifier and stabilizer to modify SLNs (Inu12/Inu18-SLNs). Inu12-SLNs and Inu18-SLNs had similar particle size as the control SLNs (P188-SLNs and Tween-SLNs) prepared with the straight chain surfactants, poloxamer 188 and tween-80 as the emulsifier, which ranged from 220 nm to 270 nm. The zeta potentials of all the SLNs formulations were slightly negative. Read More

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http://dx.doi.org/10.1691/ph.2019.8140DOI Listing
January 2019
1.003 Impact Factor

Acute abdomen in drug abusers.

Authors:
L Hána M Ryska

Rozhl Chir 2019 ;98(1):14-17

Introduction: Acute abdomen is one of the most important issues in abdominal surgery. Our study aims to describe the differences in clinical presentation of patients, in the course of their hospitalization, and in morbidity and mortality of patients with drug abuse; another aim is to describe our own experience with drug abusers with acute abdomen. Method: Patients with the history of drug abuse and with non-traumatic acute abdomen were included retrospectively to our set. Read More

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January 2019
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Advanced gastric cancer with features of a submucosal tumor diagnosed by endoscopic ultrasound-guided fine needle aspiration and boring biopsy preoperatively: A case report and literature review.

Int J Surg Case Rep 2019 8;55:223-226. Epub 2019 Feb 8.

Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Introduction: Gastric cancer with features of a submucosal tumor (GCSMT) is rare, and the preoperative diagnosis is very difficult. We present a case of GCSMT diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and boring biopsy (deeper biopsy), successfully treated with distal gastrectomy and lymph node dissection.

Presentation Of Case: An 81-year-old man with a history of myocardial infarction and type 2 diabetes mellitus was admitted to our hospital for further examination of a gastric submucosal tumor. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378837PMC
February 2019

Acute abdominal pain in patients with Crohn's disease: what urgent imaging tests should be done?

Radiologia 2019 Feb 13. Epub 2019 Feb 13.

Servicio de Radiología, Hospital Universitario Ramón y Cajal, Madrid, España.

Crohn's disease is an autoimmune disease that predominantly affects the gastrointestinal tract. Crohn's disease is diagnosed at a young age and runs a chronic course with acute flare-ups. When patients with Crohn's disease present with flare-ups at the emergency department, they are usually managed in a way similar to patients with acute abdomen; there is no consensus about the most appropriate imaging work-up for patients with flare-ups of Crohn's disease. Read More

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http://dx.doi.org/10.1016/j.rx.2018.12.003DOI Listing
February 2019
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Protocol for fast postoperative improvement (FPOI) in gastrointestinal surgery.

Cir Cir 2019 ;87(2):151-157

Cátedra de Fisiopatología, Facultad de Farmacia y Bioanálisis, Universidad de Los Andes. Mérida, Venezuela.

Introduction: Peroperative treatment has required multimodal protocols that stimulate patient evolution and shorten hospital stay.

Objective: Identify the type of pathology, intervention performed and evaluate the effectiveness of the Rapid Postoperative Improvement Protocol (RAMPO) in patients undergoing elective gastrointestinal surgery.

Method: A total of 122 patients were evaluated, a group of 61 patients received the RAMPO protocol and the other group of equal number of patients were treated with traditional protocols (Controls). Read More

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http://dx.doi.org/10.24875/CIRU.18000470DOI Listing
January 2019
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Alopecia neoplastica as a sign of visceral malignancies: a systematic review.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. Read More

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http://dx.doi.org/10.1111/jdv.15498DOI Listing
February 2019
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Primary gastrointestinal diffuse large B-cell lymphoma: A prospective study from South India.

South Asian J Cancer 2019 Jan-Mar;8(1):57-59

Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India.

Background: Gastrointestinal tract (GIT) is the most common extranodal site for non-Hodgkin's lymphoma (NHL) and constitutes about 10%-15% of all NHL. This was a prospective study to evaluate the epidemiological, clinicopathological characteristics, and treatment outcome of primary GIT diffuse large B-cell lymphoma (PGIL).

Materials And Methods: Newly diagnosed patients of PGIL with DLBCL histology were eligible. Read More

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http://dx.doi.org/10.4103/sajc.sajc_52_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348773PMC
February 2019
1 Read