192,759 results match your criteria Lower GI Tract


Should we worry about incidental gastrointestinal tract involvement in positron emission tomography/computed tomography as gastroenterologist?

Acta Gastroenterol Belg 2018 Oct-Dec;81(4):471-475

Istanbul University, Istanbul Medical Faculty, Department of Gastroenterology.

Background And Aim: Positron emission tomography/computed tomography(PET/CT) scans detects benign clinical conditions in addition to malignancy, and this leads to additional investigation and expenditure. The purpose of our study was to assess the endoscopic and histopathologic results of incidental 18F-FDG uptake in the GI tract.

Patients And Method: We enrolled 110 patients who underwent gastroscopy/colonoscopy for incidental GI tract involvement in PET/CT. Read More

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January 2019

Low-Fiber Intake Is Associated With High Production of Intraperitoneal Inflammation Biomarkers.

J Ren Nutr 2019 Jan 11. Epub 2019 Jan 11.

School of Medicine, Pontifical Catholic University of Paraná (PUCPR), Curitiba, Brazil.

Objective: Fiber intake influences disturbances in the gastrointestinal tract and is associated with systemic inflammation in the general population. Systemic and intraperitoneal inflammation play an important role in defining outcomes in peritoneal dialysis (PD), but the relationship between dietary fiber intake and inflammatory biomarkers has not yet been reported in the population on PD. The objective of the present study is to analyze whether or not fiber intake in patients on PD is associated with serum and intraperitoneal levels of inflammatory biomarkers. Read More

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http://dx.doi.org/10.1053/j.jrn.2018.10.013DOI Listing
January 2019

Diagnostic utility of nasogastric tube aspiration and the ratio of blood urea nitrogen to creatinine for distinguishing upper and lower gastrointestinal tract bleeding.

Emergencias 2018 Dic;30(6):419-423

Servicio de Aparato Digestivo, Hospital Universitari ParcTaulí. Institut d'Investigació i Innovació ParcTaulí, Barcelona, España. Departamento de Medicina. Universitat Autònoma de Barcelona, España.

Objectives: The American College of Gastroenterology's 2016 clinical guidelines for treating lower gastrointestinal (GI) tract bleeding recommends evaluating of nasogastric tube aspiration and the ratio of blood urea nitrogen (BUN) to creatinine to differentiate upper from lower GI bleeds. However, the evidence base to support recommending these 2 diagnostic variables is low. This study aimed to evaluate the diagnostic utility of nasogastric tube aspiration and the BUN-to-creatinine ratio for distinguishing between upper and lower GI bleeding. Read More

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January 2019

[Ganglioneuroblastoma in a child with chronic abdominal pain - a case report].

Dev Period Med 2018 ;22(4):364-370

II Katedra i Klinika Pediatrii, Gastroenterologii i Żywienia, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Polska.

Chronic abdominal pain is a very common complaint in the population of children and adolescents. In most cases, the usual cause are functional gastrointestinal disorders. However, in a few percent of children, the reason for persistent chronic stomach pain are organic diseases occurring in the gastrointestinal tract, as well as parenteral diseases, including uro-genital tract abnormalities, inflammation of the lower respiratory tract and cancer processes. Read More

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January 2018
1 Read

Preterm Birth has Effects on Gut Colonization in Piglets Within the First 4 Weeks of Life.

J Pediatr Gastroenterol Nutr 2019 Jan 8. Epub 2019 Jan 8.

Department of Food Science, University of Copenhagen.

Objectives: Preterm neonates have an immature gastrointestinal tract and show an altered bacterial colonization of the gut. However, it is not clear if such immature gut microbiota (GM) colonization is induced by specific delivery, diet, environment and/or host factors related to preterm birth. Using piglets as models for infants, we hypothesized that both shortened gestational age (GA) and start of enteral feeding affect GM composition after caesarean delivery and rearing in identical environments. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002259DOI Listing
January 2019
1 Read

A lipolysis-permeation setup for simultaneous study of digestion and absorption in vitro.

Mol Pharm 2019 Jan 10. Epub 2019 Jan 10.

Lipid-based formulations (LBFs) are a delivery strategy to enhance intestinal absorption of poorly water-soluble drugs. LBF performance is typically evaluated by in vitro lipolysis studies, but these do not accurately predict the in vivo performance. One possible reason is the absence of an absorptive membrane driving sink conditions in the serosal compartment. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00811DOI Listing
January 2019

22q11.2 duplications in a UK cohort with bladder exstrophy-epispadias complex.

Am J Med Genet A 2019 Jan 9. Epub 2019 Jan 9.

Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

The bladder exstrophy-epispadias complex (BEEC) comprises of a spectrum of anterior midline defects, all affecting the lower urinary tract, the external genitalia, and the bony pelvis. In extreme cases, the gastrointestinal tract is also affected. The pathogenesis of BEEC is unclear but chromosomal aberrations have been reported. Read More

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http://doi.wiley.com/10.1002/ajmg.a.61032
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http://dx.doi.org/10.1002/ajmg.a.61032DOI Listing
January 2019
1 Read

Effect of Osmolality on the Pharmacokinetic Interaction Between Apple Juice and Atenolol in Rats.

Drug Metab Dispos 2019 Jan 8. Epub 2019 Jan 8.

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.

In a recent clinical study, it was reported that the ingestion of apple juice (AJ) markedly reduced the plasma concentration of atenolol. However, our study showed that atenolol may not be a substrate of OATP2B1, so this AJ-atenolol interaction cannot be explained by inhibition of OATP2B1. On the other hand, we more recently showed that the solution osmolality influences gastrointestinal (GI) water volume, and this may indirectly affect intestinal drug absorption. Read More

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http://dx.doi.org/10.1124/dmd.118.084483DOI Listing
January 2019
1 Read

HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma.

BMC Cancer 2019 Jan 8;19(1):38. Epub 2019 Jan 8.

Department of General, Visceral and Cancer Surgery, University Hospital Cologne, Cologne, Germany.

Background: HER2 (ERBB2 or HER2/neu) is a tyrosine-kinase increasing cell proliferation. Overexpression/amplification of HER2 is correlated with worse prognosis in solid malignancies. Consequently, HER2 targeting is established in breast and upper gastrointestinal tract cancer. Read More

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http://dx.doi.org/10.1186/s12885-018-5242-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325716PMC
January 2019

Advances in Orally-delivered pH-Sensitive Nanocarrier Systems; an Optimistic Approach for the Treatment of Inflammatory Bowel Disease.

Int J Pharm 2019 Jan 4. Epub 2019 Jan 4.

Medical Clinic I, University Hospital Erlangen, Research Campus, 91052 Erlangen, Germany.

Inflammatory bowel disease (IBD) is the inflammation of the gastrointestinal tract (GIT) affecting the colon and ileum in particular. Increasing IBD prevalence worldwide is alarming, and needs to be resolved. Due to the limited therapeutic efficacy, accompanying adverse effects, dependence, and pharmacokinetics issues of the available therapy, IBD patients have compromised quality of life. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.074DOI Listing
January 2019
3.650 Impact Factor

The fundamentals of chronic pelvic pain assessment, based on international continence society recommendations.

Neurourol Urodyn 2018 Aug;37(S6):S32-S38

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

Aims: Chronic pelvic pain (CPP) is defined as a noncyclical pain that has duration of at least 6 months and can lead to decreased quality of life and physical performance. The pain can be attributed to problems in the pelvic organs and/or problems in related systems, and possible psycho-social attributes may contribute to the manifestation. Due to the complex nature, CPP syndromes are multifactorial and the terminology needs to reflect the setting. Read More

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http://doi.wiley.com/10.1002/nau.23776
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http://dx.doi.org/10.1002/nau.23776DOI Listing
August 2018
5 Reads
2.873 Impact Factor

Comparison of two different barbed suture materials for end-to-end jejuno-jejunal anastomosis in pigs.

Acta Vet Scand 2019 Jan 5;61(1). Epub 2019 Jan 5.

Department of Veterinary Sciences, University of Turin, Largo P. Braccini 2-5, Grugliasco, TO, Italy.

Background: Hand-sewn intestinal anastomoses are a fundamental procedure in both open and laparoscopic intestinal surgery. Self-retaining barbed suture devices have been tested for a variety of surgical applications. With the exception of clinical reports and various experimental studies on enterotomy, little has been published so far on the use of barbed suture for end-to-end intestinal anastomoses. Read More

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http://dx.doi.org/10.1186/s13028-018-0437-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321647PMC
January 2019

Comparison of body condition score and other minimally invasive biomarkers between dogs with gastric carcinoma and dogs with chronic gastritis.

J Am Vet Med Assoc 2019 Jan;254(2):226-235

OBJECTIVE To identify minimally invasive biomarkers to help differentiate dogs with gastric carcinoma from those with chronic gastritis. DESIGN Prospective study. ANIMALS 15 dogs with gastric carcinoma, 29 dogs with chronic gastritis, and 7 healthy dogs. Read More

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https://avmajournals.avma.org/doi/10.2460/javma.254.2.226
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http://dx.doi.org/10.2460/javma.254.2.226DOI Listing
January 2019
7 Reads

Phytase as an alleviator of high-temperature stress in broilers fed adequate and low dietary calcium.

Poult Sci 2018 Dec 28. Epub 2018 Dec 28.

AB Vista, Marlborough, Wiltshire SN8 4AN, United Kingdom.

This study aimed to investigate the effect of phytase and dietary Ca level on performance, phytate (inositol hexa-phosphate, IP6) concentration, and anti-oxidant enzyme activity in broilers exposed to cycling high environmental temperatures. A total of 2,970 day-old Cobb 400 male broilers were randomly allocated among 6 treatments, with 15 replicate pens, and 33 birds per pen. Corn-soy diets low in available phosphorus (avP, 0. Read More

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https://academic.oup.com/ps/advance-article/doi/10.3382/ps/p
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http://dx.doi.org/10.3382/ps/pey566DOI Listing
December 2018
3 Reads

Impact on intestinal permeability of pediatric hyperosmolar formulations after dilution: Studies with rat perfusion method.

Int J Pharm 2018 Dec 27;557:154-161. Epub 2018 Dec 27.

Department of Pharmacokinetics and Pharmaceutical Technology, Miguel Hernandez University, San Juan de Alicante, 03550 Alicante, Spain.

Introduction: There is no consensus on administering hyperosmolar formulations by mouth to neonates. In 1976, the Committee on Nutrition of the American Academy of Pediatrics published a recommendation of not administer formulations with an osmolarity higher than 400 mOsm/L due to the possible damage to intestine and relationship with necrotizing enterocolitis. Since this recommendation, exists a general trend of reducing osmolality of oral formulations without considering the pharmacokinetics of absorption of the drugs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183096
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http://dx.doi.org/10.1016/j.ijpharm.2018.12.047DOI Listing
December 2018
2 Reads

Lactobacillus rhamnosus GG modulates gastrointestinal absorption, excretion patterns, and toxicity in Holstein calves fed a single dose of aflatoxin B.

J Dairy Sci 2018 Dec 26. Epub 2018 Dec 26.

College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China. Electronic address:

The aim of the present study was to evaluate the effects of Lactobacillus rhamnosus GG (LGG; ATCC 53013) on growth performance and hepatotoxicity in calves fed a single dose of aflatoxin B (AFB) and to investigate the absorption, distribution, and elimination of AFB and the hydroxylated metabolite aflatoxin M (AFM) in rumen fluid, blood, and excretions. Twenty-four male Holstein calves were blocked for body weight and age and were randomly assigned to 1 of 3 treatment groups: (1) untreated control, (2) treated with 4.80 mg of AFB (AFB only), or (3) treated with 1 × 10 cfu of LGG suspension and 4. Read More

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http://dx.doi.org/10.3168/jds.2018-15444DOI Listing
December 2018

The enhancement of surface activity and nanoparticle stability through the alteration of charged amino acids of HGFI.

Colloids Surf B Biointerfaces 2018 Dec 18;175:703-712. Epub 2018 Dec 18.

The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, PR China. Electronic address:

HGFI (hydrophobin found in Grifola frondosa) is a small surface-active protein, belonging to class I hydrophobins, and can form amphipathic protein films at hydrophobic- hydrophilic material interfaces. HGFI has a low isoelectric point (pI) because no basic amino acids are present in its sequence. Here we constructed two HGFI mutants using a site-directed mutation method. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2018.12.044DOI Listing
December 2018

[The features and treatment of Xixia "May 17th" explosion accident].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Dec;30(12):1196-1199

Department of Burns and Plastic Surgery, the Affiliated Nanshi Hospital of Henan University, Nanyang 473065, Henan, China. Corresponding author: Wang Shuo, Email:

Objective: To retrospectively analyze the injury characteristics of victims and treatment strategies in the explosion accident on the 17th May 2018 in Xixia county (Xixia "May 17th" explosion accident).

Methods: Completion the Level Three treatment on time, which was depended on the leading role played by the regional trauma centers was the main rescuing mode of the work in Xixia county, where the primary and secondary treatments were the key parts. The three-level treatment model includes: the local hospital acts as a level-one emergency medical institution, county hospitals function as secondary emergency medical institutions, and other higher medical institutions are the tertiary first aid medical institutions. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.012.018DOI Listing
December 2018
6 Reads

An Unusual Case of Cecal Mesenteric Dedifferentiated Liposarcoma Involving the Ileocolic Artery Resected by Right Hemicolectomy.

Anticancer Res 2019 Jan;39(1):487-490

Department of Pathology, Immunology and Laboratory of Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Background: Colonic mesenteric dedifferentiated liposarcoma is a rare entity.

Case Report: A 65-year-old male developed a 6 cm diameter right-side intra-abdominal mesenteric mass. A biopsy of the mass was performed and the pathology diagnosis was a spindle cell neoplasm most consistent with low-grade sarcoma. Read More

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http://dx.doi.org/10.21873/anticanres.13138DOI Listing
January 2019

An Update on the Current Role of High Resolution Anoscopy in Patients With Anal Dysplasia.

Anticancer Res 2019 Jan;39(1):17-23

Division of Colorectal Surgery, Department of Surgery, Drexel University, Philadelphia, PA, U.S.A.

The incidence of anal squamous cell carcinoma (ASCC) in the U.S. is increasing, particularly in immunocompromised patients. Read More

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http://dx.doi.org/10.21873/anticanres.13075DOI Listing
January 2019

Postruminal infusion of calcium gluconate increases milk fat production and alters fecal volatile fatty acid profile in lactating dairy cows.

J Dairy Sci 2018 Dec 24. Epub 2018 Dec 24.

Trouw Nutrition Agresearch, Guelph, Ontario, Canada N1G 4T2.

Gluconic acid is a carboxylic acid naturally occurring in plants and honey. In nonruminant animals, gluconic acid has been shown to increase gastrointestinal butyrate concentrations and improve growth performance, but a ruminant application remains undescribed. This experiment examined the effects of postruminal calcium gluconate (CaG) on milk production, fecal volatile fatty acid concentrations, and plasma metabolite concentrations in lactating dairy cows. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00220302183115
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http://dx.doi.org/10.3168/jds.2018-15148DOI Listing
December 2018
3 Reads

Effects of limestone particle size and dietary Ca concentration on apparent P and Ca digestibility in the presence or absence of phytase.

Poult Sci 2018 Dec;97(12):4306-4314

Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA.

The present study evaluated the effects of limestone particle size and Ca concentration on apparent ileal digestibility (AID) of P and Ca in the presence or absence of a 6-phytase derived from Buttiauxella sp., expressed in Trichoderma. Treatment diets were corn-soybean meal (SBM) based with no added inorganic Ca or P. Read More

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http://dx.doi.org/10.3382/ps/pey304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305832PMC
December 2018

Analysis of the factors influencing the outcome of bleeding of the lower digestive tract. A report of 15 consecutives cases.

Ann Ital Chir 2018 ;89:212-216

The authors present a series of 15 patients with lower gastrointestinal bleeding. 11 (73%) out of 15 patients, were directly subjected to surgery, and 4 (37%) attempted to stop hemorrhage with angiography. In the group of patients undergoing surgery we had a mortality of 1 out of 12 (8%). Read More

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January 2018

A unique phenomenon of oral-anal contact between ticks observed in two tick species Ixodes ricinus and Dermacentor reticulatus.

Ann Agric Environ Med 2018 Dec 5;25(4):686-689. Epub 2018 Dec 5.

Chair and Department of Infectious Diseases, Medical University, Lublin, Poland.

For the first time in the world literature, the presented study describes oral-anal contact between two sympatric Ixodes ricinus and Dermacentor reticulatus ticks, which are the vectors of many pathogens in Europe. Among the specimens collected in nature, an I. ricinus male was found with the hypostome and chelicerae inserted in the anal aperture of a D. Read More

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http://dx.doi.org/10.26444/aaem/99054DOI Listing
December 2018

Idarucizumab for Dabigatran Reversal in the Management of Patients with Major Gastrointestinal Bleeding.

Circulation 2018 Oct 29. Epub 2018 Oct 29.

Thrombosis and Hemostasis, Leiden University Medical Center Leiden, NETHERLANDS.

Background: Although dabigatran has a favourable risk-benefit profile compared to vitamin K antagonist therapy for venous thromboembolism and non-valvular atrial fibrillation, major bleeding events - including gastrointestinal (GI) bleeding - may occur. Therefore, our aim was to provide insights on the efficacy and safety of idarucizumab for urgent dabigatran reversal in patients with major GI bleeding.

Methods: Patients with uncontrollable GI bleeding were enrolled from June 2014 through July 2016 in RE-VERSE AD, a prospective, multi-centre, open-label study of idarucizumab and were followed for 90 days for primary and secondary outcomes. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036710DOI Listing
October 2018
1 Read

Glucagon Like Peptide 1 and MicroRNA in Metabolic Diseases: Focusing on GLP1 Action on miRNAs.

Front Endocrinol (Lausanne) 2018 7;9:719. Epub 2018 Dec 7.

Department of Systems Medicine, University of Rome "Tor Vergata,", Rome, Italy.

Glucagon like peptide 1 (GLP1) is an incretin hormone released from the enteroendocrine L-type cells of the lower gastrointestinal tract. The active isoforms of GLP1 are rapidly degraded (<2 min) by protease dipeptidyl peptidase-4 (DPP-4) after their release. Among its functions, GLP1 exerts a pivotal role in regulating glucose and lipid metabolism. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00719
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http://dx.doi.org/10.3389/fendo.2018.00719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293193PMC
December 2018
3 Reads

A novel probiotic, Lactobacillus johnsonii 456, resists acid and can persist in the human gut beyond the initial ingestion period.

Gut Microbes 2018 Dec 22:1-23. Epub 2018 Dec 22.

a Molecular Toxicology Interdepartmental Program, Environmental Health Sciences, Fielding School of Public Health , University of California Los Angeles , Los Angeles , CA , USA.

Probiotics are considered to have multiple beneficial effects on the human gastrointestinal tract, including immunomodulation, pathogen inhibition, and improved host nutrient metabolism. However, extensive characterization of these properties is needed to define suitable clinical applications for probiotic candidates. Lactobacillus johnsonii 456 (LBJ 456) was previously demonstrated to have anti-inflammatory and anti-genotoxic effects in a mouse model. Read More

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http://dx.doi.org/10.1080/19490976.2018.1547612DOI Listing
December 2018

Effects of Anti-Helicobacter pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases.

Clin Gastroenterol Hepatol 2018 Dec 20. Epub 2018 Dec 20.

Department of Internal Medicine, Division of Gastroenterology, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109 United States. Electronic address:

Background & Aims: Helicobacter pylori induces immune tolerance and is associated with a lower risk for immune-mediated disorders, such as autoimmune and inflammatory bowel diseases (IBD). We aimed to determine the effects of treatment for H pylori infection on the incidence of autoimmune disease and IBD.

Methods: We collected data from the National Health Insurance Research Database in Taiwan on patients younger than 18 years old without a prior diagnosis of autoimmune disease or IBD. Read More

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http://dx.doi.org/10.1016/j.cgh.2018.12.014DOI Listing
December 2018

Robotic total gastrectomy with π-shaped esophagojejunostomy using a linear stapler as a novel technique.

World J Surg Oncol 2018 Dec 21;16(1):238. Epub 2018 Dec 21.

Department of Gastrointestinal Surgery, Department of General Surgery, First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei, 230022, Anhui, China.

Objective: To evaluate the intraoperative and short-term postoperative outcomes of a novel robotic intracorporeal π-shaped esophagojejunostomy (EJS) after D2 total gastrectomy (TG) using the Da Vinci robotic surgical system for intracorporeal anastomosis after TG.

Background: Intracorporeal π-shaped EJS, using a linear stapler, was recently reported for laparoscopic total gastrectomy in patients with gastric cancer. However, robotic intracorporeal π-shaped EJS using a linear stapler has not been reported. Read More

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http://dx.doi.org/10.1186/s12957-018-1542-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303991PMC
December 2018
1 Read

[Littré's strangled umbilical hernia in children: a rare complication due to a common malformation of the small bowel].

Pan Afr Med J 2018 17;30:214. Epub 2018 Jul 17.

Clinique Universitaire de Chirurgie Pédiatrique CNHU-HKM, Cotonou, Bénin.

Meckel's diverticulum is the most common congenital anomaly of the small bowel. Although it is a common anomaly in the general population, its occurrence in a hernial sac, in particular at the umbilicus, is uncommon and it is known as Littré's hernia. We here report the case of a 6-month female infant, admitted with painful irreducible umbilical swelling. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.214.14486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294977PMC
January 2019
1 Read

The clinical application value of MR diffusion-weighted imaging in the diagnosis of rectal cancer: A retrospective study.

Medicine (Baltimore) 2018 Dec;97(51):e13732

Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China.

The present study evaluated the clinical potential of magnetic resonance (MR) diffusion-weighted imaging (DWI) in the diagnosis of rectal cancer.A total of 84 patients confirmed with rectal cancer were used as study subjects in the present study. All patients received conventional sequence MR T1WI, T2WI, and DWI examination as well as operative pathological examination. Read More

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http://dx.doi.org/10.1097/MD.0000000000013732DOI Listing
December 2018
1 Read
5.723 Impact Factor

Adenocarcinoma of the ascending colon in a 31-year-old pregnant woman: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13707

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Eastern District, Beijing.

Rationale: Colorectal cancer (CRC) is the 2nd most common type of cancer in females and the 3rd in males, worldwide. It occurs rarely during pregnancy and is often associated with poor prognosis, due to the unspecific manifestations until advanced stage. Majority of CRC are localized in the rectum (63%) and the sigmoid colon (20%) during pregnancy. Read More

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http://dx.doi.org/10.1097/MD.0000000000013707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320218PMC
December 2018
1 Read

Narrow band imaging and white light endoscopy in the characterization of a polypectomy scar: A single-blind observational study.

World J Gastroenterol 2018 Dec;24(45):5179-5188

Gastroenterology Department, Hospital del Mar, Barcelona 08003, Spain.

Aim: To assess the incremental benefit of narrow band imaging (NBI) and white light endoscopy (WLE), randomizing the initial technique for the detection of residual neoplasia at the polypectomy scar after an endoscopic piecemeal mucosal resection (EPMR).

Methods: We conducted an observational study in an academic center to assess the incremental benefit of NBI and WLE randomly applied 1:1 (NBI-WLE or WLE-NBI) in the follow-up of a post-EPMR scar by the same endoscopist.

Results: A total of 112 EPMR scars were included. Read More

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http://www.wjgnet.com/1007-9327/full/v24/i45/5179.htm
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http://dx.doi.org/10.3748/wjg.v24.i45.5179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288651PMC
December 2018
2 Reads

Pelvic exenterations for primary rectal cancer: Analysis from a 10-year national prospective database.

World J Gastroenterol 2018 Dec;24(45):5144-5153

Colorectal Unit, Hospital Universitario y Politecnico La Fe, University of Valencia, Valencia 46026, Spain.

Aim: To identify short-term and oncologic outcomes of pelvic exenterations (PE) for locally advanced primary rectal cancer (LAPRC) in patients included in a national prospective database.

Methods: Few studies report on PE in patients with LAPRC. For this study, we included PE for LAPRC performed between 2006 and 2017, as available, from the Rectal Cancer Registry of the Spanish Association of Surgeons [Asociación Española de Cirujanos (AEC)]. Read More

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http://www.wjgnet.com/1007-9327/full/v24/i45/5144.htm
Publisher Site
http://dx.doi.org/10.3748/wjg.v24.i45.5144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288654PMC
December 2018
3 Reads

Rupture of the common bile duct due to blunt trauma, presenting difficulty in diagnosis.

BMJ Case Rep 2018 Dec 10;11(1). Epub 2018 Dec 10.

Surgery, JCHO Chukyo Hospital, Nagoya, Japan.

Rupture of the common bile duct because of blunt trauma is extremely rare. Preoperative diagnosis is very difficult because bile causes little peritoneal irritation. We present a case of a 19-year-old young woman with rupture of the common bile duct due to blunt trauma. Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-226467
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http://dx.doi.org/10.1136/bcr-2018-226467DOI Listing
December 2018
1 Read

Bioaccessibility and cellular uptake of β-carotene in emulsion-based delivery systems using scallop (Patinopecten yessoensis) gonad protein isolates: effects of carrier oil.

Food Funct 2018 Dec 19. Epub 2018 Dec 19.

Department of Food Science, University of Massachusetts, Amherst, Massachusetts 01003, USA.

Emulsion-based delivery systems were structured by using scallop gonad protein isolates (SGPIs) as novel food-grade emulsifiers. The effects of carrier oil, including the long chain triglycerides (LCT) and medium chain triglycerides (MCT), on the bioaccessibility and cellular uptake of β-carotene (BC) were investigated. Both LCT and MCT delivery systems remained stable at pH 7-8 but aggregated at lower pH values (3-6) according to the results of light scattering and microscopy measurements. Read More

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http://dx.doi.org/10.1039/c8fo01390jDOI Listing
December 2018

Aspirin eugenol ester regulates cecal contents metabolomic profile and microbiota in an animal model of hyperlipidemia.

BMC Vet Res 2018 Dec 18;14(1):405. Epub 2018 Dec 18.

Key Lab of New Animal Drug Project of Gansu Province; Key Lab of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Science of Chinese Academy of Agricultural Sciences, No.335, Jiangouyan, Qilihe district, Lanzhou, 730050, China.

Background: Hyperlipidemia, with an increasing of prevalence, has become one of the common metabolic diseases in companion animal clinic. Aspirin eugenol ester (AEE) is a novel compound that exhibits efficacious anti-hyperlipidemia activities. However, its mechanisms are still not completely known. Read More

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http://dx.doi.org/10.1186/s12917-018-1711-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299661PMC
December 2018

Optimal processing of ESD specimens to avoid pathological artifacts.

Tech Coloproctol 2018 Nov 17;22(11):857-866. Epub 2018 Dec 17.

Institute of Pathology Spedali Civili, Brescia, Italy.

Background: En bloc endoscopic submucosal dissection (ESD) has been recently introduced as a treatment for precancerous/neoplastic gastrointestinal conditions. The aim of the present study was histological assessment of en bloc ESD specimens.

Methods: Fifty-three ESD specimens were positioned over a cellulose acetate support (40 specimens; 12 from the upper gastrointestinal tract and 28 from the lower gastrointestinal tract) or pinned with nails on polystyrene or cork (13 specimens; 7 from the upper gastrointestinal tract and 6 from the lower gastrointestinal tract). Read More

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http://dx.doi.org/10.1007/s10151-018-1887-xDOI Listing
November 2018

SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity.

J Biol Chem 2018 Dec 17. Epub 2018 Dec 17.

Division of Pharmacology & Toxicology, The University of Texas at Austin, United States.

The essential metal manganese becomes neurotoxic at elevated levels. Yet, mechanisms by which brain manganese homeostasis is regulated are unclear. Loss-of-function mutations in SLC30A10, a cell surface-localized manganese efflux transporter in the brain and liver, induce familial manganese neurotoxicity. Read More

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http://dx.doi.org/10.1074/jbc.RA118.005628DOI Listing
December 2018

Lower expression of endogenous intestinal alkaline phosphatase may predict worse prognosis in patients with Crohn's disease.

BMC Gastroenterol 2018 Dec 17;18(1):188. Epub 2018 Dec 17.

Division of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.

Backgrounds: Intestinal alkaline phosphatase (IAP) plays important role in gut homeostasis. We aimed to evaluate the expression of endogenous IAP and to assess the clinical course according to the expression of endogenous IAP in patients with Crohn's disease (CD).

Methods: A total of 32 consecutive patients (14 males) with CD were included in the study. Read More

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http://dx.doi.org/10.1186/s12876-018-0904-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296121PMC
December 2018

Common Bacterial and Viral Infections: Review of Management in the Pregnant Patient.

Ann Pharmacother 2018 Dec 17:1060028018817935. Epub 2018 Dec 17.

1 University of South Carolina College of Pharmacy, Columbia, SC, USA.

Objective: To review the treatment of common bacterial and viral infections occurring in the pregnant patient.

Data Sources: A literature search of MEDLINE was performed (inception to October 2018). The Centers for Disease Control and Prevention website was utilized for additional information. Read More

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http://dx.doi.org/10.1177/1060028018817935DOI Listing
December 2018
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Interference with the lower gut-liver axis induces remission of primary sclerosing cholangitis in a patient with ulcerative colitis.

BMJ Open Gastroenterol 2018 14;5(1):e000239. Epub 2018 Nov 14.

Department of Gastroenterology, Bedford Hospital South Wing, Bedford, UK.

The gut-liver axis describes the complex interactions between gut microbiota, the small and large bowel, the immune system and the liver. Current evidence associates abnormalities within the gut-liver axis with liver disease such as primary sclerosing cholangitis (PSC). PSC is believed to be an immune-mediated disease though the exact mechanism of its pathogenesis remains unknown. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267462PMC
November 2018
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A case of completely isolated advanced enteric duplication cyst cancer performed partial pancreatectomy.

Int J Surg Case Rep 2018 Nov 27;54:83-86. Epub 2018 Nov 27.

Department of Gastroenterological Surgery, Higashiosaka City Medical Center, Nishiiwata 3-4-5, Higashiosaka, Osaka, 567-8588, Japan.

Introduction: Enteric duplication cysts are rare and, in addition, isolated enteric duplication cysts are lower morbidity prevalence rate. These cysts lack a connection to the gastrointestinal tract or the adjacent mesenteric vasculature and have only been reported in 10 case reports. In these reports, only two reports were cases with malignant transformation. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297057PMC
November 2018
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Perineurioma of the colon: an uncommon tumor with an unusual location. Report of a case and review of the literature.

Pathologica 2018 Sep;110(2):111-115

Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Anatomic Pathology, Policlinico Universitario-Vittorio Emanuele, University of Catania, Italy.

Perineurioma is a relatively rare benign peripheral nerve sheath tumor composed of cells resembling to normal perineurium. Although this tumor may arise in the context of a nerve (intraneural perineurioma), extraneural perineurioma does occur, frequently involving the soft tissues of the lower and upper extremities, trunk and head and neck. Rarely it has also been reported in visceral organs, including gastrointestinal tract. Read More

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September 2018

Microbiome and disease in the upper airway.

Curr Opin Allergy Clin Immunol 2019 Feb;19(1):1-6

Department of Head and Neck Surgery, University of Colorado Medical Center, Denver, California, USA.

Purpose Of Review: Microbiome refers to the genetic potential of resident microorganisms that inhabit a given niche. The exact role of the microbiome and its relation to chronic disease processes remains largely unknown, although various associations have been observed. We reviewed current literature investigating the microbiome of the upper airway by subsite (nasal cavity, sinus cavities, nasopharynx, and larynx) and its relation to chronic inflammatory disease processes. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000495DOI Listing
February 2019
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Disease-Specific Enteric Microbiome Dysbiosis in Inflammatory Bowel Disease.

Front Med (Lausanne) 2018 20;5:304. Epub 2018 Nov 20.

Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.

Inflammatory Bowel disease (IBD) is traditionally divided into Crohn's disease (CD) and ulcerative colitis (UC). UC is a relapsing non-transmural inflammatory disease that is restricted to the colon and is characterized by flare-ups of bloody diarrhea. CD is a chronic, segmental localized granulomatous disease that can affect any part of the entire gastrointestinal tract. Read More

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http://dx.doi.org/10.3389/fmed.2018.00304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256240PMC
November 2018
3 Reads

Silodosin: An Update on Efficacy, Safety and Clinical Indications in Urology.

Adv Ther 2019 Jan 6;36(1):1-18. Epub 2018 Dec 6.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

Introduction: Silodosin determines smooth muscle relaxation in bladder and prostate tissues, increases bladder blood flow in conditions of chronic bladder ischemia and regulates the activity of transcriptional factors responsible for stromal growth and prostate hyperplasia. Phase III trials have already demonstrated the efficacy and safety of silodosin in the treatment of patients bothered by lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH).

Objective: We aimed to describe the rationality for the use of silodosin and to summarize the current literature on the use of Silodosin for the treatment of LUTS. Read More

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http://dx.doi.org/10.1007/s12325-018-0854-2DOI Listing
January 2019
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ANALYSIS OF RISK FACTORS AND POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH CROHN'S DISEASE.

Arq Gastroenterol 2018 Jul-Sep;55(3):252-257

Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Departamento de Cirurgia e Ortopedia, Botucatu, SP, Brasil.

Background: The post-operative complications rate is greater in patients with Crohn's disease than in other abdominal surgeries due to other benign conditions. Prevention and management of such complications are important factors in the care of these patients.

Objective: The objectives of this research are to analyze the rate of postoperative complications and the major risk factors in patients with Crohn's disease. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-63DOI Listing
January 2019
5 Reads

Impact of Ileal Transposition Surgical Intervention on Antioxidant Status Measured in Liver Tissue of Obese Zucker Rats (Crl:ZUC-Lepr).

Oxid Med Cell Longev 2018 11;2018:7342451. Epub 2018 Nov 11.

Clinic of General, Visceral, Transplantation and Vascular Surgery, Hospital of the Ludwig Maximilian University, Munich, Germany.

Background: The main factor characteristic for low-grade systemic inflammation typical for obesity is oxidative stress (OS). Reactive oxygen species (ROS) production is higher and more increased in time in the obese patients than in lean subjects.

Aims: To assess the effect of ileal transposition (IT) and sham types of bariatric procedures on the antioxidative systems in the liver tissue of Zucker rats (Crl:ZUC Lepr). Read More

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https://www.hindawi.com/journals/omcl/2018/7342451/
Publisher Site
http://dx.doi.org/10.1155/2018/7342451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252239PMC
January 2019
4 Reads