213,082 results match your criteria Lower GI Tract

Agreement between maximum and mean handgrip strength measurements in cancer patients.

PLoS One 2022 1;17(7):e0270631. Epub 2022 Jul 1.

Postgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.

Background And Aim: Handgrip strength (HGS) can be used to identify probable sarcopenia, by measuring maximum strength and/or through the average of three measurements. This study analyzed the agreement between maximum and mean HGS measurements in identifying probable sarcopenia in cancer patients.

Methods: Adult individuals of both sexes diagnosed with malignant neoplasm were evaluated. Read More

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Protein-Losing Enteropathy Resolved by Eradication.

Eur J Case Rep Intern Med 2022 26;9(5):003312. Epub 2022 May 26.

Department of Internal Medicine, Hospital Garcia de Orta, Almada, Lisbon, Portugal.

Protein-losing enteropathy (PLGE) is an uncommon condition with a multifactorial origin, that is characterized by excessive loss of serum proteins into the gastrointestinal tract, resulting in hypoproteinaemia and oedema. The authors present the case of a 24-year-old man admitted to hospital for a 2-month history of lower extremity oedema and diarrhoea with a secretory pattern. Blood analysis revealed hypoalbuminaemia and iron deficiency anaemia. Read More

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The Effect of Covid-19 Severity on Lower Urinary Tract Symptoms Manifestations.

Med Arch 2022 Apr;76(2):127-130

Department of Urology, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital, Malang.

Background: The dominant symptoms in the patient with COVID-19 are symptoms of the respiratory organ system such as cough, rhinorrhea, dan shortness of breathing. Nonetheless, some reports found involvement of another organ system, including the gastrointestinal system, cardiovascular system, central nervous system, urinary system, such as lower urinary tract symptoms. Hematuria related to infection of COVID-19 virus on adult and kids were reported. Read More

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Expression of chemerin in intestinal mucosa of calves with comparable expression level with other antimicrobial proteins.

Anim Sci J 2022 Jan;93(1):e13750

Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.

Neonatal calves are highly susceptible to infectious disorders including diarrhea. Therefore, epithelial innate immunity, including antimicrobial peptides/proteins (AMPs), is important during the early stage of their lives. Chemerin, a multifunctional protein that was originally identified as a chemokine, possesses a potent antimicrobial activity. Read More

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January 2022

Risk Assessment and QbD-Based Optimization of Sorafenib Tosylate Colon Targeted Bilayer Tablet: In Vitro Characterization, In Vivo Pharmacokinetic, and In Vivo Roentgenography Studies.

AAPS PharmSciTech 2022 Jul 1;23(6):184. Epub 2022 Jul 1.

Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, 411038, Maharashtra, India.

The employment of site-specific administration in colon is a promising technique to improve efficacy and reduce systemic side effects of anticancer medications used in colorectal cancer. However, the physiology of the gastrointestinal tract and colonic environment limit the efficient delivery of orally administered anticancer drugs to the colon. These prerequisites can be fulfilled by a release modulated colon targeted drug delivery system (CTDDS) based on pH-dependent chronotherapeutic bilayer tablet of sorafenib tosylate (ST). Read More

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Prevalence and Clinical Significance of Incidental Focal F-FDG Uptake in Colon on PET/CT Imaging.

Mol Imaging Radionucl Ther 2022 Jun;31(2):96-103

University of Health Sciences Turkey, Prof. Dr. Cemil Taşcıoğlu City Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey.

Objectives: The present study aimed to identify the prevalence of focal uptake in the colon on fluorine-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) studies performed for the evaluation of malignancies other than colon, to detect the rate of malignancy in incidental focal F-FDG avid colonic lesions and to investigate if any possible role of maximum standardized uptake value (SUV) values in the discrimination of malignant lesions from premalignant and benign ones exist.

Methods: We retrospectively reviewed the files of 8,017 patients with known or suspected malignancy, who underwent whole-body F-FDG PET/CT at our institution during the period November 2017 to November 2019. Patients showing a single site of focally increased colonic F-FDG uptake that was more intense compared to liver uptake on F-FDG PET studies and referred to colonoscopy were enrolled in the study. Read More

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A rare case of acute appendicitis with Enterobius vermicularis.

Pediatr Int 2022 Jan;64(1):e15195

Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Kagoshima, Japan.

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January 2022

Early reoperation after adult living-donor liver transplantation is associated with poor survival.

Korean J Transplant 2019 Dec;33(4):128-134

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Patients who undergo reoperation after living-donor liver transplantation (LDLT) have poor outcomes. However, the specific outcomes of patients undergoing reoperation due to gastrointestinal (GI) tract-related complications following adult LDLT are relatively unknown. In the present study, we investigated the relationship between the causes and outcomes of reoperation after LDLT and classified the risk groups. Read More

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December 2019

Therapy response of glucocorticoid-refractory acute GVHD of the lower intestinal tract.

Bone Marrow Transplant 2022 Jun 29. Epub 2022 Jun 29.

Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, Albert Ludwigs University (ALU), Freiburg, Germany.

Acute graft-versus-host disease (aGVHD) is a major life-threatening complication of allogeneic hematopoietic cell transplantation. While most studies report therapy-response of aGVHD including a cumulative grade of skin, liver and intestinal tract manifestations, there is a lack of information specifically on lower gastrointestinal tract aGVHD (GI-GVHD) therapy-response, which is highly relevant in light of novel therapies that target intestinal regeneration such as IL-22, R-spondin or GLP-2. Here we retrospectively analyzed patients who developed GI-GVHD over a 6-year period. Read More

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[Analysis of risk factors for post-polypectomy bleeding and polyp recurrence after colonoscopic polypectomy in children].

Zhonghua Er Ke Za Zhi 2022 Jul;60(7):666-670

Department of Gastroenterology, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.

To explore the incidence and the risk factors of post-polypectomy bleeding and polyp recurrence after colonoscopic high-frequency electrocoagulation snare polypectomy. Clinical data of 1 826 children who underwent colonoscopic high-frequency electrocoagulation snare polypectomy in the Children's Hospital, Zhejiang University School of Medicine from January 2009 to December 2020 was retrospectively analyzed. Demographic characteristics, endoscopic manifestations, pathological features, diagnosis, occurrence of post-polypectomy bleeding and polyp recurrence were collected. Read More

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[Analysis of clinical characteristics of 126 children with recurrent intussusception].

S X Bie M Z Jiang

Zhonghua Er Ke Za Zhi 2022 Jul;60(7):655-659

Pediatric Endoscopy Center and Department of Gastroenterology, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou 310052, China.

To analyze and summarize the clinical features in children with recurrent intussusception. This retrospective cohort study collected the clinical data of 126 children with recurrent intussusception who were admitted to the Children's Hospital of Zhejiang University School of Medicine due to "abdominal pain, paroxysmal crying, vomiting, bloody stools" from January 1, 2015 to November 30, 2019. The clinical manifestations of recurrent intussusception between ≤3 years old group and >3 years old group were compared, the etiology and age characteristics of pathologic lead points (PLP) were analyzed, and the clinical characteristics of PLP group and non-PLP group were also compared. Read More

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Effect of T1R3 Taste Receptor Gene Deletion on Dextran Sulfate Sodium-Induced Colitis in Mice.

J Nutr Sci Vitaminol (Tokyo) 2022 ;68(3):204-212

Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School.

Taste receptor type 1 member 3 (T1R3) recognize umami or sweet tastes and also contributes type 2 immunity and autophagy in small intestine and muscle cells, respectively. Since imbalance of type 1 and type 2 immunity and autophagy affect intestinal bowel disease (IBD), we hypothesized that T1R3 have a potential role in the incidence and progression of colitis. In the present study, we investigated whether genetic deletion of T1R3 impacted aggravation of DSS-induced colitis in mice. Read More

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Women's techniques for pleasure from anal touch: Results from a U.S. probability sample of women ages 18-93.

PLoS One 2022 29;17(6):e0268785. Epub 2022 Jun 29.

OMGYES Research Group, For Goodness Sake LLC, Berkeley, California, United States of America.

The study purpose was to assess, in a U.S. probability sample of women, the specific ways women have discovered to experience pleasure from anal touch. Read More

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Arq Bras Cir Dig 2022 24;35:e1662. Epub 2022 Jun 24.

Kafkas University, Faculty of Veterinary Medicine, Department of Surgery, TR-36000 Kars, TURKEY.

Aim: Although many methods have been defined for colonic anastomosis, anastomotic leak still remains important for sepsis control and successful healing. The purpose of this study was to compare the effects of conventional suture, polyglactin 910 mesh, and omental flap coverage on healing and anastomotic leak in experimental colonic anastomosis in rats.

Method: This study was conducted on 18 Wistar rats and the animals were divided into three groups as follows: Group 1: primary suture group; Group 2: primary suture plus polyglactin 910 mesh group; and Group 3: primary suture plus omental flap coverage group. Read More

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Ileo-colic lipomatosis complicated by cecum perforation and mimicking acute appendicitis: a case report.

Acta Biomed 2022 Jun 29;93(S1):e2022208. Epub 2022 Jun 29.

S.O.C. Chirurgia Generale, P.O. Santissima Trinità, Cagliari, Italy..

Lipomatosis of the colon is rare in clinical practice although the majority of cases are found incidentally. In rare circumstances, patients may presents with acute complications such as bowel obstruction, intussusception, or perforation. Here we report a case of colonic lipomatosis that present as localized peritonitis mimicking acute appendicitis in a young COVID patient. Read More

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Effect of 17β-estradiol on the daily pattern of ACE2, ADAM17, TMPRSS2 and estradiol receptor transcription in the lungs and colon of male rats.

PLoS One 2022 28;17(6):e0270609. Epub 2022 Jun 28.

Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic.

Covid-19 progression shows sex-dependent features. It is hypothesized that a better Covid-19 survival rate in females can be attributed to the presence of higher 17β-estradiol (E2) levels in women than in men. Virus SARS-CoV-2 is enabled to enter the cell with the use of angiotensin converting enzyme 2 (ACE2). Read More

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Goat milk fermented with combined lactic acid bacterium alter microbial community structures and levels of the targeted short-chain fatty acids in the large intestine of mice.

Food Res Int 2022 Jul 16;157:111352. Epub 2022 May 16.

Hospital of Shaanxi Normal University, Shaanxi Normal University, Xi'an 710119, China. Electronic address:

The present study investigated effects of the fermented goat milk (FGM) produced with a combination of Streptococcus salivarius subsp. thermophilus and Lactobacillus delbrueckii subsp. bulgaricus (SL) and with another one of SL as well as Bifidobacterium animalis subsp. Read More

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TLR4 regulates RORγt regulatory T-cell responses and susceptibility to colon inflammation through interaction with Akkermansia muciniphila.

Microbiome 2022 Jun 27;10(1):98. Epub 2022 Jun 27.

Department of Gastroenterology, The Second Affiliated Hospital of Third Military Medical University, 400037, Chongqing, China.

Background: Well-balanced interactions between gut microbiota and the immune system are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). Toll-like receptor 4 (TLR4) functions as a sensor mediating the crosstalk between the intestinal commensal microbiome and host immunity, but the influence of TLR4 on the shaping of intestinal microbiota and immune responses during colon inflammation remains poorly characterized. We investigated whether the different susceptibilities to colitis between wild-type (WT) and TLR4 mice were gut microbiota-dependent and aimed to identify the potential immunity modulation mechanism. Read More

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Epigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4CD8 T cells in ulcerative colitis.

J Transl Med 2022 Jun 27;20(1):289. Epub 2022 Jun 27.

Department of Gastroenterology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Luohu District, No. 1017, Dongmen North Road, Shenzhen, 518020, Guangdong, China.

Background And Aims: Ulcerative colitis (UC) is a heterogeneous disorder with complex pathogenesis. Therefore, in the present study, we aimed to assess genome-wide DNA methylation changes associated explicitly with the pathogenesis of UC.

Methods: DNA methylation changes were identified by comparing UC tissues with healthy controls (HCs) from the GEO databases. Read More

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Autoamputation of the appendix and survival of the amputated part: a rare case report and literature review.

BMC Surg 2022 Jun 27;22(1):249. Epub 2022 Jun 27.

The Second Hospital of Dalian Medical University, Zhongshan Road, Shahekou District, Dalian, Liaoning, People's Republic of China.

Background: Autoamputation of the appendix, i.e., complete separation of a part of the appendix without any surgical intervention, has been rarely documented in the literature in recent years. Read More

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Giant cell tumor of soft tissue of the colon: a case report and review of the literature.

BMC Gastroenterol 2022 Jun 27;22(1):317. Epub 2022 Jun 27.

Department of Pathology, College of Medicine, Chosun University, Gwangju, Republic of Korea.

Background: A giant cell tumor (GCT) is a benign neoplasm characterized by mixture of mononuclear cells and multinucleated cells. A GCT of soft tissue (GCT-ST) is developed in various extraosseous sites, but GCT-ST of the gastrointestinal tract is very rare. GCT-ST usually has a benign course, but rare cases reported malignant potential of the tumor. Read More

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Use of Bayes factors to evaluate the effects of host genetics, litter and cage on the rabbit cecal microbiota.

Genet Sel Evol 2022 Jun 27;54(1):46. Epub 2022 Jun 27.

Institute of Agrifood Research and Technology (IRTA)-Animal Breeding and Genetics, Caldes de Montbui, Barcelona, Spain.

Background: The rabbit cecum hosts and interacts with a complex microbial ecosystem that contributes to the variation of traits of economic interest. Although the influence of host genetics on microbial diversity and specific microbial taxa has been studied in several species (e.g. Read More

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Defining Sepsis Phenotypes-Two Murine Models of Sepsis and Machine Learning.

Shock 2022 Jun;57(6):268-273

Department of Pathology & Laboratory Medicine, Boston Medical Center, Boston University, Boston, Massachusetts.

Introduction: The immunobiology defining the clinically apparent differences in response to sepsis remains unclear. We hypothesize that in murine models of sepsis we can identify phenotypes of sepsis using non-invasive physiologic parameters (NIPP) early after infection to distinguish between different inflammatory states.

Methods: Two murine models of sepsis were used: gram-negative pneumonia (PNA) and cecal ligation and puncture (CLP). Read More

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Wiad Lek 2022 ;75(5 pt 2):1415-1417


Ulcerative colitis is an inflammatory bowel disease. Opposite to Crohn's disease, it affects only the mucosa and submucosa of the large intestine. The disease can have episodes of flares and remissions. Read More

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Wiad Lek 2022 ;75(5 pt 2):1323-1327


Objective: The aim: Study the effect of antibiotics of different groups on the condition of the colon microflora in infants with acute respiratory pathology.

Patients And Methods: Materials and methods: 140 infants with acute respiratory pathology were examined. Clinical, laboratory and instrumental examination, assessment of the functional state of all organs and systems, chest x ray, clinical signs of the colon microbiocenosis violation, analysis of bacteriological examination and immunological studies of local colon immunity (immunoglobulin concentration (sIgA, IgA, IgG, IgM) in coprofiltrates) were done. Read More

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Lower gastrointestinal bleeding in a male with jejunal Dieulafoy's lesion after successful surgical resection: A case report and literature review.

Medicine (Baltimore) 2022 Jun 24;101(25):e29474. Epub 2022 Jun 24.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Introduction: Dieulafoy's lesion (DL) presented with small bowel bleeding constitutes a group of rare and potentially life-threatening prognosis. Several case series have described this condition, yet it remains unclear as to what is the optimal treatment and predicted outcome for patients who have been diagnosed.

Patient Concerns: We present a 21-year-old male experiencing bloody stool for 1 day. Read More

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A Soft Sensor for Bleeding Detection in Colonoscopies.

Adv Intell Syst 2022 Apr 20;4(4). Epub 2022 Feb 20.

Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA.

Colonoscopies allow surgeons to detect common diseases i.e. colorectal cancer, ulcers and other ailments. Read More

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Gut Microbiota Ecology and Inferred Functions in Children With ASD Compared to Neurotypical Subjects.

Front Microbiol 2022 9;13:871086. Epub 2022 Jun 9.

Department of Diagnostics and Laboratory Medicine, Unit of Microbiology and Diagnostic Immunology, Unit of Microbiomics, and Multimodal Laboratory Medicine Research Area, Unit of Human Microbiome, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare, Rome, Italy.

Autism spectrum disorders (ASDs) is a multifactorial neurodevelopmental disorder. The communication between the gastrointestinal (GI) tract and the central nervous system seems driven by gut microbiota (GM). Herein, we provide GM profiling, considering GI functional symptoms, neurological impairment, and dietary habits. Read More

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[Current status of research on short-term urogenital function after transanal total mesorectal excision and laparoscopic total mesorectal excision].

Zhonghua Wei Chang Wai Ke Za Zhi 2022 Jun;25(6):552-557

Department of General Surgery, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Thanks to the new surgical approach, transanal total mesorectal excision (taTME) has a better operative field exposure than laparoscopic-assisted total mesorectal excision (laTME), especially for male patients with obesity, pelvic stenosis or prostate hypertrophy. Nevertheless, whether the urogenital function and quality of life after taTME are better as compared to laTME requires further study. According to the existing studies, taTME and laTME are not significantly different in symptoms of the urology system for male patients, but some large sample clinical studies show that the incidence of urethral mechanical injury after taTME is higher. Read More

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