45,631 results match your criteria Low-Grade Astrocytoma


Carotid Endarterectomy for Medical Therapy-resistant Symptomatic Low-grade Stenosis.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Background: Plaque characteristics play pivotal roles in ischemic events, but stenosis severity does not accurately reflect carotid plaque volume due to expansive remodeling in some patients with low-grade stenosis (LGS).

Objective: This study aimed to assess the safety, efficacy, and durability of carotid endarterectomy (CEA) for symptomatic LGS.

Methods: Study participants comprised 61 consecutive patients who underwent CEA for symptomatic carotid stenosis. Read More

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December 2018

Two Double-hit Lymphomas Cases: A Molecular Cytogenetic Approach.

J Assoc Genet Technol 2018 ;44(4):141-145

Allina Health, Minneapolis, MN.

Objectives: Double-hit lymphomas represent 5% of cases of diffuse large B-cell lymphomas (DLBCL). They are currently recognized as highgrade B-cell lymphomas (HGBCL) with rearrangements of MYC and BCL2 and/or BCL6 by the 2016 WHO classification. One of these rearrangements is the translocation of the BCL2 gene (18q21. Read More

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January 2018
2 Reads

ATF2 promotes urothelial cancer outgrowth via cooperation with androgen receptor signaling.

Endocr Connect 2018 Dec;7(12):1397-1408

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA.

We investigated the functional role of ATF2, a transcription factor normally activated via its phosphorylation in response to phospho-ERK/MAPK signals, in the outgrowth of urothelial cancer. In both neoplastic and non-neoplastic urothelial cells, the expression levels of androgen receptor (AR) correlated with those of phospho-ATF2. Dihydrotestosterone treatment in AR-positive bladder cancer cells also induced the expression of phospho-ATF2 and phospho-ERK as well as nuclear translocation and transcriptional activity of ATF2. Read More

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December 2018

Retrospective analysis of 11 cases of primary cardiac valve tumors.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Ultrasound Diagnosis, The Second Affiliated Hospital (Xinqiao Hospital) of Chinese People's Liberation Army Medical University; Chongqing-China.

Objective: To explore the clinical features and surgical treatment experience of primary cardiac valve tumor.

Methods: The present study retrospectively analyzed the clinical data of 11 patients with primary valvular tumors who underwent surgical treatment in our department from 1980 to 2016. Echocardiography of preoperative patients was indicated as a heart valve tumor. Read More

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December 2018

Impact of neoadjuvant chemotherapy on short-term complications and survival following radical cystectomy.

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium.

Objectives: To compare perioperative and short-term postoperative complication rates between patients receiving radical cystectomy (RC) after neoadjuvant chemotherapy (NAC) and patients undergoing RC alone. Secondary objectives were to compare overall survival (OS) and cancer-specific survival (CSS).

Materials And Methods: Clinico-pathological data of all patients who received RC between 1996 and 2015 were retrospectively collected. Read More

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December 2018
1 Read

Identification of Grade-associated MicroRNAs in Brainstem Gliomas Based on Microarray Data.

J Cancer 2018 31;9(23):4463-4476. Epub 2018 Oct 31.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Tiantanxili 6, Dongcheng District, Beijing, 100050, China.

Gliomas arising in the brainstem are rare tumours that are difficult to surgically resect, and the microRNAs (miRNAs) and signalling pathways associated with brainstem gliomas (BSGs) are largely unknown. To identify grade-associated miRNAs in BSGs, a microarray analysis of 10 low-grade and 15 high-grade BSGs was performed in this study. Differentially expressed miRNAs (DE-miRNAs) were identified, and the functional DE-miRNAs were selected. Read More

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October 2018
1 Read

Low-Grade Inflammation in the Association Between Mild-to-Moderate Hypertriglyceridemia and Risk of Acute Pancreatitis: A Study of More Than 115000 Individuals from the General Population.

Clin Chem 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark;

Background: How mild-to-moderate hypertriglyceridemia (2-10 mmol/L; 177-886 mg/dL) potentially causes acute pancreatitis is unknown; however, cellular studies indicate that inflammation might be a driver of disease progression. We tested the hypotheses that () mild-to-moderate hypertriglyceridemia is associated with low-grade inflammation and that () the association between mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis depends on low-grade inflammation.

Methods: From the Copenhagen General Population Study and the Copenhagen City Heart Study, 117865 men and women 20-100+ years of age with measurements of nonfasting plasma triglycerides at baseline were followed prospectively for development of acute pancreatitis. Read More

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December 2018
3 Reads

Age-related response to an acute innate immune challenge in mice: proteomics reveals a telomere maintenance-related cost.

Proc Biol Sci 2018 Dec 5;285(1892). Epub 2018 Dec 5.

CNRS, Université de Strasbourg, IPHC UMR 7178, 67000 Strasbourg, France

Ageing is characterized by the impairment of the acute innate immune response and the upregulation of low-grade inflammation, i.e. inflammaging. Read More

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December 2018
1 Read

Changes in Dietary Intake and Adherence to the NU-AGE Diet Following a One-Year Dietary Intervention among European Older Adults-Results of the NU-AGE Randomized Trial.

Nutrients 2018 Dec 4;10(12). Epub 2018 Dec 4.

Division of Human Nutrition, Wageningen University & Research, Wageningen, P.O. Box 17, 6700 AA Wageningen, The Netherlands.

Background: The Mediterranean Diet has been proposed as an effective strategy to reduce inflammaging, a chronic low grade inflammatory status, and thus, to slow down the aging process. We evaluated whether a Mediterranean-like dietary pattern specifically targeting dietary recommendations of people aged over 65 years (NU-AGE diet) could be effective to shift dietary intake of older adults towards a healthful diet.

Methods: Adults aged 65⁻80 years across five EU-centers were randomly assigned to a NU-AGE diet group or control group. Read More

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December 2018
1 Read

Diagnostic performance of a stepwise cytological algorithm for biliary malignancy in primary sclerosing cholangitis.

Liver Int 2018 Dec 2. Epub 2018 Dec 2.

Division of Hepatology, Department of Upper GI Diseases, Karolinska University Hospital, Stockholm, Sweden.

Background And Aims: Detection of early cholangiocarcinoma (CCA) in primary sclerosing cholangitis (PSC) is challenging. The aim of this study was to evaluate the diagnostic accuracy of a stepwise approach to biliary brush cytology with sequential use of fluorescence in-situ hybridization (FISH) for the detection of biliary malignancy in PSC.

Method: We retrospectively studied consecutive patients with PSC who underwent biliary brushings at Karolinska University Hospital between 2009 and 2015 (n = 208). Read More

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December 2018
1 Read

Incidence of and risk factors for major haemorrhage in patients treated with ibrutinib: An integrated analysis.

Br J Haematol 2018 Dec 2. Epub 2018 Dec 2.

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Ibrutinib, a Bruton tyrosine kinase inhibitor, is approved for treatment of various B-cell malignancies. In ibrutinib clinical studies, low-grade haemorrhage was common, whereas major haemorrhage (MH) was infrequent. We analysed the incidence of and risk factors for MH from 15 ibrutinib clinical studies (N = 1768), including 4 randomised controlled trials (RCTs). Read More

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December 2018

Cellularity in low-grade Pseudomyxoma peritonei impacts recurrence-free survival following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

Langenbecks Arch Surg 2018 Dec 1. Epub 2018 Dec 1.

Department of General, Visceral and Transplant Surgery, University of Tübingen, Comprehensive Cancer Center, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany.

Purpose: Documentation of cellularity in Pseudomyxoma peritonei (PMP) is not performed on a regular basis in everyday clinical practice, but is recommended by the PSOGI (Peritoneal Surface Oncology Group International). We investigated the impact of cellularity in PMP following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on recurrence-free survival.

Methods: Data from 25 patients with low-grade (American Joint Committee on Cancer grade G1) PMP were retrospectively evaluated. Read More

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December 2018

New insights on occupational exposure and bladder cancer risk: a pooled analysis of two Italian case-control studies.

Int Arch Occup Environ Health 2018 Nov 30. Epub 2018 Nov 30.

Unit of Epidemiology, Regional Health Service, ASLTO3, Via Sabaudia 164, 10095, Grugliasco, TO, Italy.

Purpose: The main risk factor for bladder cancer (BC) is cigarette smoking, but also occupational exposure to carcinogens is relevant, causing about 4-10% of BC. We aimed at investigating the association between BC risk, occupations held in the past and exposure to occupational carcinogens, also assessing whether these associations were influenced by tumour grade.

Methods: We pooled data from two Italian case-control studies on male BC, analyzing 893 cases and 978 controls. Read More

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November 2018

Management and risk factors for incomplete resection associated with jumbo forceps polypectomy for diminutive colorectal polyps: a single-institution retrospective study.

Surg Endosc 2018 Nov 30. Epub 2018 Nov 30.

Department of Anatomical Pathology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan.

Background: Cold forceps polypectomy is simple and widely used in clinical practice. However, there are concerns about the risk of incomplete resection using this technique. In recent years, it has been reported that polypectomy with jumbo forceps (JF) is an effective treatment modality for diminutive polyps (DPs) because JF are able to remove large tissue samples with the combined advantage of a higher complete histological resection rate for DPs than standard forceps. Read More

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November 2018

Multiplex Ligation-Dependent Probe Amplification (MLPA) for Prenatal Diagnosis of Common Aneuploidies.

Methods Mol Biol 2019 ;1885:161-170

Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.

Multiplex Ligation-dependent Probe Amplification (MLPA) is a method to determine the copy number of up to 60 genomic DNA sequences in a single multiplex PCR based reaction.MLPA probes consist of two oligonucleotides that can hybridize next to each other on a certain DNA sequence of interest, where they are ligated. All ligated probes are subsequently amplified by PCR using a single set of primers. Read More

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January 2019

Juxtatumoral perinephric fat analysis in clear cell renal cell carcinoma.

Abdom Radiol (NY) 2018 Nov 30. Epub 2018 Nov 30.

Keck School of Medicine, University of Southern California, Radiology, Los Angeles, CA, 90033, USA.

Purpose: The purpose of the study was to evaluate the feasibility of using contrast-enhanced computed tomography (CECT)-based texture analysis (CTTA) metrics to differentiate between juxtatumoral perinephric fat (JPF) surrounding low-grade (ISUP 1-2) versus high-grade (ISUP 3-4) clear cell renal cell carcinoma (ccRCC).

Methods: In this IRB-approved study, we retrospectively queried the surgical database between June 2009 and April 2016 and identified 83 patients with pathologically confirmed ccRCC (low grade: n = 54, mean age = 61.5 years, 18F/35M; high grade n = 30, mean age = 61. Read More

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November 2018

Endoscopic therapy for confirmed low-grade dysplasia in Barrett's esophagus.

Transl Gastroenterol Hepatol 2018 29;3:83. Epub 2018 Oct 29.

Unità Operativa Complessa di Endoscopia Digestiva Chirurgica, Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche Istituto di Clinica Chirurgica Generale e Terapia Chirurgica Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Roma, Italia.

Barrett's esophagus (BE) is a premalignant condition characterized by replacement of the esophageal lining with metastatic columnar epithelium. To date, the management in case of confirmed low-grade dysplasia (LGD) remains controversial. In this article we summarize the available endoscopic options and their results in terms of efficacy and safety in the treatment of confirmed LGD in BE. Read More

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October 2018
1 Read

Clinical outcomes of the "resect and discard" strategy using magnifying narrow-band imaging for small (< 10 mm) colorectal polyps.

Endosc Int Open 2018 Dec 21;6(12):E1382-E1389. Epub 2018 Nov 21.

Department of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.

 The "resect and discard" strategy is a new paradigm for the management of small colorectal polyps that reduces the cost and effort related to pathological diagnosis after polypectomy. This retrospective study aimed to clarify the clinical outcome of the "resect and discard" strategy for small colorectal polyps.  The clinical records were reviewed from 501 consecutive patients who underwent the "resect and discard" strategy for colorectal polyps smaller than 10 mm at our hospital between January 2008 and December 2010. Read More

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December 2018

Understanding risk and refining surveillance following tumor resection for low grade non-muscle invasive bladder cancer.

Transl Androl Urol 2018 Dec;7(6):987-989

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

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December 2018

Reclassification of lesions in biopsies by fine-needle aspiration of pancreas and biliary tree using Papanicolaou classification.

J Gastrointest Oncol 2018 Oct;9(5):847-852

Department of Cytopathology, Hospital General de Mexico "Gerardo Liceaga", Mexico City, Mexico.

Background: Our aim was to evaluate the application of the classification of the Papanicolaou Cytopathology Society for the report of biopsies by fine-needle aspiration (FNA) of pancreas and bile duct.

Methods: The FNAs obtained consecutively during 1 year were analyzed. Descriptive statistics were performed and sensitivity, specificity, positive predictive value, negative predictive value, and cytohistological correlation were determined. Read More

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October 2018

Genomic Reduction at TTC Repeats in the Bacterial Genome of Treated Cases of Hansen's Disease: A Possible Survival Mechanism of .

Indian J Dermatol 2018 Nov-Dec;63(6):449-454

Department of Biochemistry, IPGMER, Kolkata, West Bengal, India.

Introduction: has a small genome and a tendency of persisting as a very low-grade infection. The authors have shown earlier, that the changes in TTC repeats, in genome may contribute to the restriction of the pathogenicity of the bacterium and its survival strategy in case of pure neural Hansen's disease. We suspect, that a similar genomic reduction if happens in treated cases of Hansen's disease, can be a determining factor for developing persisters and relapse. Read More

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December 2018

Application of diffusion tensor imaging in brain lesions: A comparative study of neoplastic and non-neoplastic brain lesions.

Neurol India 2018 Nov-Dec;66(6):1667-1671

Department of Biostatistics and Health Informatics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Purpose: To evaluate the role of diffusion tensor imaging (DTI) in the differentiation of neoplastic and non-neoplastic brain lesions, on the basis of DTI parameters, fractional anisotropy (FA) and mean diffusivity (MD) from the lesion (L) and the perilesional edema (PE).

Material And Methods: Patients with newly diagnosed 25 neoplastic [10 high grade gliomas (HGG), 11 metastases, 4 low grade glioma (LGG)] and 25 non-neoplastic [13 tuberculomas and 12 neurocysticercosis (NCC)] brain lesions underwent an MRI, including the DTI sequences. Fractional anisotropy from the lesion (FAL) and mean diffusivity from the lesion (MDL), as well as fractional anisotropy from the perilesional edema (FAPE), and mean diffusivity from the perilesional edema (MDPE) were calculated and quantified using region of interest (ROI) based assessment on DTI derived FA and MD parametric maps. Read More

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December 2018

Laryngeal stenosis in children: Types, grades and treatment strategies.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Pediatric Surgery Division, Hospital Universitario 12 de Octubre, Avda. De Córdoba s/n, Madrid 28041, Spain.

Introduction: Laryngeal stenosis is infrequent in children and usually secondary to endotracheal intubation. The aims of this study were to review the outcomes of the distinct endoscopic and surgical procedures and to suggest a technical modification for one of them.

Methods: Retrospective review of patients with the diagnosis of laryngeal stenosis treated in an academic tertiary care institution between 2000 and 2017. Read More

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November 2018

Isocitrate Dehydrogenase 1 Expression in Canine Gliomas.

J Comp Pathol 2018 Nov 20;165:33-39. Epub 2018 Oct 20.

Translational Research and Animal Clinical Trial Studies Group, Section of Veterinary Neurology and Neurosurgery, Australia.

Mutation of the isocitrate dehydrogenase 1 (IDH1) gene at codon 132 has been identified in approximately 70% of low-grade (II and III) human gliomas and secondary glioblastomas, with the IDH1 R132H point mutation representing 92.7% of these mutations. In people, the presence of an IDH1 gene mutation is associated with a better prognosis (both progression-free survival time and overall survival time) and a better response to therapy, including chemotherapy and radiation therapy. Read More

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November 2018

Papillary pattern in clear cell renal cell carcinoma: Clinicopathologic, morphologic, immunohistochemical and molecular genetic analysis of 23 cases.

Ann Diagn Pathol 2018 Nov 22;38:80-86. Epub 2018 Nov 22.

Department of Pathology, Charles University, Faculty of Medicine in Plzeň, Pilsen, Czech Republic. Electronic address:

Clear cell renal cell carcinoma (ccRCC), the most common histologic subtype of RCCs, demonstrates a wide spectrum of morphologic features (i.e., low-grade spindle cell, syncytial giant cells, and mucin-producing cells). Read More

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November 2018

Cannabinoid receptor type-1 partially mediates metabolic endotoxemia-induced inflammation and insulin resistance.

Physiol Behav 2018 Nov 29;199:282-291. Epub 2018 Nov 29.

Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA. Electronic address:

Circulating levels of bacterial lipopolysaccharide (LPS) or endotoxin are chronically elevated in obesity (metabolic endotoxemia), resulting in low-grade inflammation. Metabolic endotoxemia has been identified as a triggering factor for obesity-associated metabolic complications such as insulin resistance. Furthermore, LPS has been shown to modulate endocannabinoid synthesis and notably to induce cannabinoid receptor type-1 (CB1) ligand synthesis. Read More

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November 2018

Integrated Analysis of Mouse and Human Gastric Neoplasms Identifies Conserved microRNA Networks in Gastric Carcinogenesis.

Gastroenterology 2018 Nov 28. Epub 2018 Nov 28.

Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States; Department of Veterans Affairs, Miami Healthcare System, Miami, FL, United States; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, United States.

Background & Aims: microRNAs (miRNAs) are small non-coding RNAs that bind to 3'UTR regions of mRNAs to promote their degradation or block their translation. Mice with disruption of the trefoil factor 1 gene (Tff1) develop gastric neoplasms. We studied these mice to identify conserved miRNA networks involved in gastric carcinogenesis. Read More

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November 2018

The Expressional Pattern of Invasion-Related Extracellular Matrix Molecules in CNS Tumors.

Cancer Invest 2018 Dec 3:1-12. Epub 2018 Dec 3.

a Department of Neurosurgery , University of Debrecen , Debrecen , Hungary.

Aim Of The Study: Astrocytomas are primary CNS malignancies which infiltrate the peritumoral tissue, even when they are low-grade. Schwannomas are also primary CNS tumors, however, they do not show peritumoral infiltration similarly to brain metastases which almost never invade the neighboring parts of brain. Extracellular matrix is altered in composition in various cancer types and is proposed to play an important role in the development of invasiveness of astrocytic tumors. Read More

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December 2018

Three-Tiered versus Two-Tiered Classification of Squamous Dysplasia in Cervical Cytology: Results of a Follow-Up Study.

Acta Cytol 2018 Dec 5:1-6. Epub 2018 Dec 5.

Institut für Biometrie und Klinische Epidemiologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objective: Regarding cytological findings of squamous dysplasia, a comparison was made between a three-tiered classification - low-grade squamous intraepithelial lesion (LSIL), high-grade SIL/cervical intraepithelial neoplasia 2 (HSIL/CIN2), and HSIL/CIN3 - and a two-tiered classification - LSIL and HSIL. The respective risk for CIN2+ and CIN3+ was calculated to make decisions regarding management.

Methods: A total of 2,949 women with first-time cytologic findings of squamous dysplasia (LSIL, HSIL/CIN2, or HSIL/CIN3) between January 2013 and June 2016 were enrolled. Read More

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December 2018
1 Read

Malignant Lymphoma of the Ovary: A Diagnostic Pitfall of Intraoperative Consultation.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Departments of Obstetrics and Gynecology (N.I., Y.F., T.S., A.K., T.O., F.K.) Pathology (Y. Ikura, Y. Iwai) Hematology (M.O.), Takatsuki General Hospital, Takatsuki, Japan.

Primary ovarian lymphomas are rare, but can potentially evoke diagnostic problems. We present a case of ovarian lymphoma, in which an ambiguous intraoperative pathologic report led to overtreatment (unnecessary surgery). A 73-yr-old woman with fatigue and low-grade fever was diagnosed as having a left ovarian tumor by imaging modalities. Read More

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December 2018
1 Read

Garcinol Reduces Obesity in High-Fat Diet-Fed Mice by Modulating Gut Microbiota Composition.

Mol Nutr Food Res 2018 Dec 5:e1800390. Epub 2018 Dec 5.

P. S. Lee, C. Y. Teng, M. H. Pan, Institute of Food Science and Technology, National Taiwan University, Taipei, 10617, Taiwan.

Scope: Obesity has become a major health problem worldwide and is associated with low-grade chronic inflammation and intestinal dysbiosis. This study was conducted to investigate the chemopreventive effects of garcinol, a polyisoprenylated benzophenone derivative isolated from the fruit rind of Garcinia indica. We sought to delineate how garcinol protects against obesity in high-fat diet (HFD)-induced mice and determine whether its anti-obesity effects are related to gut microbiota. Read More

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December 2018
4.603 Impact Factor

The effectiveness of non-operative treatment in high-grade liver and spleen injury in children.

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):569-574

Department of Pediatric Surgery, Marmara University Faculty of Medicine, İstanbul-Turkey.

Background: Although a nonoperative treatment approach is preferred for blunt liver and spleen trauma in childhood, there are significant differences between clinics in the algorithms used. The approach to high-grade liver and spleen injury is still controversial, particularly as grade V liver and spleen injuries are not included in the American Pediatric Surgical Association guideline. The aim of this study was to present experience with a non-operative treatment approach to children with high-grade liver and spleen injuries. Read More

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November 2018
3 Reads

Impact of ureteral access sheath force of insertion on ureteral trauma: In vivo preliminary study with 7 patients.

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):514-520

Sorbonne Université, GRC n°20 LITHIASE RENALE, AP-HP, Hôpital Tenon, Paris-France.

Background: Ureteral access sheaths (UASs) are commonly used in retrograde intra-renal surgery (RIRS). Despite their advantages, there is a risk of ureteral trauma during their placement and subsequent stricture following surgery. The aim of this study was to evaluate the UAS force of insertion (FOI) during placement and its impact on ureteral trauma. Read More

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November 2018

Skin toxicity after chest wall/breast plus level III-IV lymph nodes treatment with helical tomotherapy.

Cancer Invest 2018 Dec 5:1-8. Epub 2018 Dec 5.

a Radiation Oncology Section , Department of Surgical and Biomedical Sciences , University of Perugia and Perugia General Hospital , Italy.

Introduction: To evaluate the incidence of toxicity in breast cancer with helical tomotherapy (HT).

Materials And Methods: 51 patients with breast cancer were assigned to postoperative radiotherapy by means of HT to the chest wall/breast plus draining nodes. During HT treatment, toxicity was monitored and were assessed using the Common Terminology Criteria for Adverse Events 4. Read More

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December 2018
1 Read

Re-irradiation for recurrent glioma: outcome evaluation, toxicity and prognostic factors assessment. A multicenter study of the Radiation Oncology Italian Association (AIRO).

J Neurooncol 2018 Dec 4. Epub 2018 Dec 4.

Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, Rozzano, 20089, Milan, Italy.

Introduction: The prognosis of glioma is dismal, and almost all patients relapsed. At recurrence time, several treatment options are considered, but to date there is no a standard of care. The Neurooncology Study Group of the Italian Association of Radiation Oncology (AIRO) collected clinical data regarding a large series of recurrent glioma patients who underwent re-irradiation (re-RT) in Italy. Read More

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December 2018
3 Reads

Aqueous thermogalvanic cells with a high Seebeck coefficient for low-grade heat harvest.

Nat Commun 2018 Dec 4;9(1):5146. Epub 2018 Dec 4.

Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074, Wuhan, China.

Thermogalvanic cells offer a cheap, flexible and scalable route for directly converting heat into electricity. However, achieving a high output voltage and power performance simultaneously from low-grade thermal energy remains challenging. Here, we introduce strong chaotropic cations (guanidinium) and highly soluble amide derivatives (urea) into aqueous ferri/ferrocyanide ([Fe(CN)]/[Fe(CN)]) electrolytes to significantly boost their thermopowers. Read More

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December 2018
3 Reads

[Establishment of a rat model of dimethylbenzanthracene-induced vulvar squamous intraepithelial lesions].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1318-1324

College of Biomedical Engineering, Chongqing Medical University/State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology/Chongqing Key Laboratory of Biomedical Engineering/ Chongqing Collaborative Innovation Center for Minimally Invasive and Noninvasive Medicine, Chongqing 400016, China.

Objective: To establish a SD rat model of vulvar squamous intraepithelial lesions.

Methods: Seventy female SD rats were randomized into 4 groups, namely the blank control group (=10), mechanical irritation group (=10), acetone solution group (=10), and mechanical irritation with DMBA acetone solution group (=40, model group), and the corresponding treatments were administered 3 times a week for 14 weeks. The changes of the vulvar skin of the rats were observed regularly until the 18th week. Read More

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November 2018
1 Read

UBC Test-A Urinary Point-of-Care (POC) Assay for Diagnosis of Bladder Cancer with a focus on Non-Muscle Invasive High-Grade Tumors: Results of a Multicenter-Study.

Int J Mol Sci 2018 Dec 2;19(12). Epub 2018 Dec 2.

University Hospital for Urology, Klinikum Oldenburg, School of Medicine and Health Sciences Carl von Ossietzky University Oldenburg, Oldenburg D-26133, Germany.

Objectives: UBC Test measures soluble fragments of cytokeratins 8 and 18 in urine. We present results of a multicenter study using an updated version of UBC Test in bladder cancer patients, patients with urinary bladder cancer positive history, and healthy controls.

Material And Methods: In total 530 urine samples have been included in this study. Read More

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December 2018
1 Read

The Role of Omega-3 Fatty Acids in the Setting of Coronary Artery Disease and COPD: A Review.

Nutrients 2018 Dec 2;10(12). Epub 2018 Dec 2.

Department of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Chronic obstructive pulmonary disease (COPD) is a growing healthcare concern and will represent the third leading cause of death worldwide within the next decade. COPD is the result of a complex interaction between environmental factors, especially cigarette smoking, air pollution, and genetic preconditions, which result in persistent inflammation of the airways. There is growing evidence that the chronic inflammatory state, measurable by increased levels of circulating cytokines, chemokines, and acute phase proteins, may not be confined to the lungs. Read More

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December 2018
2 Reads

Anogenital Verrucous Carcinoma-A case report.

Int J Surg Case Rep 2018 Nov 27;54:7-9. Epub 2018 Nov 27.

Department of Plastic Surgery and Breast Surgery, Zealand University Hospital, Roskilde, Denmark.

Introduction: Verrucous carcinoma is an uncommon variant of low-grade squamous cell malignancy with a low malignant potential but a high risk of recurrence.

Presentation Of Case: We report a case of a Human Papilloma Virus negative local verrucous carcinoma in the perianal area of a 45-year old otherwise healthy female. The tumor presented clinically as a persistent genital wart not responding to usual dermatologic local therapy. Read More

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November 2018
2 Reads

Epilepsy surgery

Rev Prat 2017 12;67(10):1111-1115

Service de neurochirurgie, centre hospitalier Sainte-Anne, université Paris-Descartes Paris, France.

Epilepsy surgery. Epilepsy surgery is indicated for adults or children with partial, drug-resistant and disabling epilepsy. It has developed over the last few decades through better identification of candidates, advances in imaging and surgical techniques. Read More

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December 2017
4 Reads

On high-risk, low-grade glioma: What distinguishes high from low?

Cancer 2018 Dec 4. Epub 2018 Dec 4.

The Brain Tumor Center at Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands.

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December 2018

Can obesity-induced inflammation in skeletal muscle and intramuscular adipose tissue accurately detect liver fibrosis?

J Musculoskelet Neuronal Interact 2018 Dec;18(4):509-524

Department of Pathology, Medical School, University of Patras, Patras, Greece.

Objectives: Obesity is characterized by a chronic, low grade, systemic inflammation. However, little is known about the role of skeletal muscle, which represents an active metabolic organ whose activities need to be determined. The purpose of our study was to detect relationships between skeletal muscle and adipose tissue inflammation with nonalcoholic fatty liver disease (NAFLD) and diabetes, as well as to explore associations with clinicopathological parameters. Read More

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December 2018
1 Read

No transformation of a fundic gland polyp with dysplasia into invasive carcinoma after 14 years of follow-up in a proton pump inhibitor-treated patient: A case report.

Pathol Int 2018 Dec 4. Epub 2018 Dec 4.

Division of Diagnostic Pathology, Shiga University of Medical Science Hospital, Otsu, Japan.

A fundic gland polyp (FGP) is a common gastric polyp. Intraepithelial neoplasia in FGPs, referred to as FGP with dysplasia, is often seen in patients with familial adenomatous polyposis (FAP). In sporadic FGPs, low-grade dysplasia (LGD) is rare, and high-grade dysplasia (HGD) or carcinoma arising from sporadic FGPs is extremely rare. Read More

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December 2018
2 Reads

[Paraffin section thickness in immunohistochemical detection of p16 expression in cervical tissue samples].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):362-366

Department of Pathology, Zhongshan Boai Hospital Affiliated to Southern Medical University, Zhongshan 528400, Guangdong Province, China.

Objective: To investigate paraffin section thickness in immunohistochemical detection of p16 expression in cervical tissue samples.

Methods: p16 immunohistochemical staining was performed in 150 cases of chronic cervicitis, 126 cases of low-grade squamous intraepithelial lesions(LSIL), 96 cases of high-grade squamous intraepithelial lesions (HSIL) and 78 cases of cervical cancer from January 2014 to March 2018 in Zhongshan Boai Hospital. The results of p16 protein expression in paraffin sections with thickness of 2, 3, 4, 5 and 6 μm were compared using Logistic regression analysis. Read More

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February 2018

[Value of combined detection of claudin 4 and high-risk human papilloma virus in high-grade squamous intraepithelial lesion and cervix squamous cell carcinoma].

Authors:
Chenhong Di Fan Jin

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):344-350

Department of Reproductive Genetics, Women's Hospital, Zhejiang University School of Medicine, Key Laboratory of Reproductive Genetics, Ministry of Education, Hangzhou 310006, China.

Objective: To investigate the expression of claudin 4 (CLDN4) in cervical tissues from patients with different cervical lesions, and to explore the value of combined detection of CLDN4 and high risk human papilloma virus (HR-HPV).

Methods: The cervical tissue specimens of low-grade squamous intraepithelial lesion (LSIL, =30), high-grade squamous intraepithelial lesion (HSIL, =30), squamous cell carcinoma (SCC, =30) as well as chronic cervicitis (control, =30) were collected from the Sir Run Run Shaw Hospital of Zhejiang University during June 2015 and December 2016. The expression of CLDN4 protein in tissue specimens was detected by immunohistochemistry, HR-HPV was detected by real-time quantitative PCR, and the cervical exfoliated cells were examined by thinprep cytologic test (TCT). Read More

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February 2018

Biological mesh is a safe and effective method of abdominal wall reconstruction in cytoreductive surgery for peritoneal malignancy.

BJS Open 2018 Dec 2;2(6):464-469. Epub 2018 Aug 2.

Peritoneal Malignancy Institute Basingstoke and North Hampshire Hospital Basingstoke RG24 9NN UK.

Background: Patients with peritoneal malignancy often have multiple laparotomies before referral for cytoreductive surgery (CRS). Some have substantial abdominal wall herniation and tumour infiltration of abdominal incisions. CRS involves complete macroscopic tumour removal and hyperthermic intraperitoneal chemotherapy (HIPEC). Read More

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December 2018

Role of Exercise in Vascular Function and Inflammatory Profile in Age-Related Obesity.

J Immunol Res 2018 28;2018:7134235. Epub 2018 Oct 28.

Department of Neuroscience, Biomedicine and Movement Science, University of Verona, Verona, Italy.

In western countries, aging is often accompanied by obesity and age-related obesity is characterized by vascular dysfunction and a low-grade inflammatory profile. Exercise is a nonpharmacological strategy able to decrease the development and incidence of risk factors for several health-threatening diseases. Nonetheless, its long-term effect on vascular function and inflammation in age-related obesity is still unclear. Read More

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October 2018
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The role of ultrasonography in detecting urinary tract calculi compared to CT scan.

Res Rep Urol 2018 15;10:199-203. Epub 2018 Nov 15.

Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: To evaluate the accuracy of ultrasonography (US) in measuring the urinary tract stone using non-contrast computed tomography (NCCT) as the standard reference.

Patients And Methods: A total of 184 patients suspected with urolithiasis who had undergone NCCT and US radiologic investigation from 2015 to 2017 were enrolled in this study. The sensitivity, specificity, and stone size measured in US were validated by NCCT. Read More

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November 2018

Detection of Individual Prostate Cancer Foci via Multiparametric Magnetic Resonance Imaging.

Eur Urol 2018 Nov 30. Epub 2018 Nov 30.

Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. Electronic address:

Background: Multiparametric magnetic resonance imaging (mpMRI) undoubtedly affects the diagnosis and treatment of localized prostate cancer (CaP). However, clinicians need a better understanding of its accuracy and limitations in detecting individual CaP foci to optimize management.

Objective: To determine the per-lesion detection rate for CaP foci by mpMRI and identify predictors of tumor detection. Read More

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November 2018
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