Search Our Scientific Publications & Authors

Acta Neuropathol 2022 Jun 21. Epub 2022 Jun 21.

Department of Neuropediatrics, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Augustenburger Platz 1, Mittelallee 8, 13353, Berlin, Germany.

Pathol Oncol Res 2022 25;28:1610067. Epub 2022 May 25.

Department of Neurosurgery, Chongqing Red Cross Hospital (Jiangbei District People's Hospital), Chongqing, China.

Glioblastoma (GBM), which occasionally occurs in pediatric patients, is the most common tumor of the central nervous system in adults. Clinically, GBM is classified as low-grade to high-grade (from 1 to 4) and is characterized by late discovery, limited effective treatment methods, and poor efficacy. With the development of immunotherapy technology, effective GBM treatment strategies are of great significance. Read More

Front Immunol 2022 23;13:853074. Epub 2022 May 23.

College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.

Glioma is the most common malignant tumor of the central nervous system. Tumor purity is a source of important prognostic factor for glioma patients, showing the key roles of the microenvironment in glioma prognosis. In this study, we systematically screened functional characterization related to the tumor immune microenvironment and constructed a risk model named Glioma MicroEnvironment Functional Signature (GMEFS) based on eight cohorts. Read More

Front Immunol 2022 23;13:899710. Epub 2022 May 23.

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.

Despite a generally better prognosis than high-grade glioma (HGG), recurrence and malignant progression are the main causes for the poor prognosis and difficulties in the treatment of low-grade glioma (LGG). It is of great importance to learn about the risk factors and underlying mechanisms of LGG recurrence and progression. In this study, the transcriptome characteristics of four groups, namely, normal brain tissue and recurrent LGG (rLGG), normal brain tissue and secondary glioblastoma (sGBM), primary LGG (pLGG) and rLGG, and pLGG and sGBM, were compared using Chinese Glioma Genome Atlas (CGGA) and Genotype-Tissue Expression Project (GTEx) databases. Read More

Neurooncol Adv 2022 Jan-Dec;4(1):vdac049. Epub 2022 Apr 13.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

Background: Pediatric gliomas comprise a diverse set of brain tumor entities that have substantial long-term ramifications for patient survival and quality of life. However, the study of these tumors is currently limited due to a lack of authentic models. Additionally, many aspects of pediatric brain tumor biology, such as tumor cell invasiveness, have been difficult to study with currently available tools. Read More

JCI Insight 2022 Jun 22;7(12). Epub 2022 Jun 22.

Department of Cancer Biology, and.

Novel therapeutic strategies targeting glioblastoma (GBM) often fail in the clinic, partly because preclinical models in which hypotheses are being tested do not recapitulate human disease. To address this challenge, we took advantage of our previously developed spontaneous Qk/Trp53/Pten (QPP) triple-knockout model of human GBM, comparing the immune microenvironment of QPP mice with that of patient-derived tumors to determine whether this model provides opportunity for gaining insights into tumor physiopathology and preclinical evaluation of therapeutic agents. Immune profiling analyses and single-cell sequencing of implanted and spontaneous tumors from QPP mice and from patients with glioma revealed intratumoral immune components that were predominantly myeloid cells (e. Read More

Nat Immunol 2022 Jun 27;23(6):971-984. Epub 2022 May 27.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a substantial protumorigenic immune component. Knowledge of the GBM immune microenvironment during tumor evolution and standard of care treatments is limited. Using single-cell transcriptomics and flow cytometry, we unveiled large-scale comprehensive longitudinal changes in immune cell composition throughout tumor progression in an epidermal growth factor receptor-driven genetic mouse GBM model. Read More

Cureus 2022 Apr 23;14(4):e24411. Epub 2022 Apr 23.

Radiation Oncology, University of Mississippi Medical Center, Jackson, USA.

Parkinson's syndrome is a group of signs and symptoms where the core issue is bradykinesia and could be a manifestation of idiopathic parkinsonism (Parkinson's disease, PD), secondary parkinsonism, or parkinsonism due to neurodegenerative disease. PD is the most common cause of Parkinson's syndrome, accounting for approximately 80% of cases. The secondary causes of Parkinson's syndrome include tumors, trauma, hydrocephalus, chemotherapy, medications including amphotericin B, metoclopramide, and radiation treatment. Read More

Neuro Oncol 2022 May 23. Epub 2022 May 23.

Children's Hospital Los Angeles, Department of Pediatrics.

Background: The incidence and biology of IDH1/2 mutations in pediatric gliomas are unclear. Notably, current treatment approaches by pediatric and adult providers vary significantly. We describe the frequency and clinical outcomes of IDH1/2-mutant gliomas in pediatrics. Read More

Front Surg 2022 2;9:827675. Epub 2022 May 2.

Neurosurgical Service, KK Women's and Children's Hospital, Singapore, Singapore.

Introduction: The treatment of pediatric optic pathway gliomas (OPG) is challenging. At present, most centers provide individualized treatment to maximize progression free survival (PFS) and minimize morbidity. We aim to report our experience in the management of pediatric OPG, and investigate factors associated with an increased duration of remission after treatment. Read More

Neuroophthalmology 2022 2;46(3):171-177. Epub 2021 Aug 2.

Ophthalmology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Two cases of optic neuropathy due to superficial siderosis (SS) are reported in two patients, aged 29 and 38 years, operated for intracranial neoplasms, the first one with a desmoplasic infantile ganglioglioma excised in 1991, and the other one with a pilocytic astrocytoma, operated on in 1997, 1998 and 2016. Both patients presented with progressive loss of visual acuity, as a result of bilateral optic nerve atrophy, as well as unsteadiness, ataxic gait and hearing loss. Magnetic resonance imaging (MRI) of the brain and spine, including gradient echo (GRE) T2-weighted acquisitions, revealed thin optic nerves and strong hypointensity with susceptibility artefacts corresponding to haemosiderin deposits within the meningeal layers of the spine, the infra- and supratentorial spaces of the brain and the peri-optic sheaths in both patients. Read More

J Mass Spectrom Adv Clin Lab 2022 Apr 29;24:80-89. Epub 2022 Apr 29.

Maastricht MultiModal Molecular Imaging (M4I) Institute, Division of Imaging Mass Spectrometry, Maastricht University, 6229 ER Maastricht, The Netherlands.

Introduction: The main goal of brain tumour surgery is to maximize tumour resection while avoiding neurological deficits. Accurate characterization of tissue and delineation of resection margins are, therefore, essential to achieve optimal surgical results.

Objectives: The primary objective of this study was to develop and validate a mass spectrometry- based technique for the molecular characterization of high- and low-grade glioma tissue during surgery. Read More

Indian J Pathol Microbiol 2022 May;65(Supplement):S42-S49

Department of Neuropathology Laboratory, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

Low-grade gliomas are the most common primary central nervous system (CNS) neoplasms in the pediatric age group. The majority of these tumors are circumscribed, while diffuse low-grade gliomas are relatively rare. The pediatric type diffuse low-grade gliomas (pDLGG) have a distinctly different biological behavior, molecular profile, and clinical outcome as compared to their adult counterpart. Read More

Front Pediatr 2022 26;10:870951. Epub 2022 Apr 26.

Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: To analyze the clinical character of giant pediatric supratentorial tumor (GPST) and explore prognostic factors.

Materials And Methods: We analyzed the clinical data comprising of 35 cases of GPST from a single center between January 2015 and December 2020. The tumor volume was measured by 3D slicer software based on preoperative magnetic resonance imaging (MRI). Read More

Chin Neurosurg J 2022 May 12;8(1):11. Epub 2022 May 12.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: To describe the epidemiological characteristics of central nervous system (CNS) tumors in children, based on the neurosurgery department of Beijing Tiantan Hospital.

Methods: From January 2015 to December 2019, 3180 children were histopathologically diagnosed with CNS tumors based on the 2016 World Health Organization (WHO) classification of tumors. Patients were 0 to 15 years old. Read More

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2022 Apr;44(2):276-285

Department of Epidemiology and Medical Statistics,School of Public Health,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046,China.

Objective To investigate the relationship between the expression of glutathione peroxidase(GPX)genes and the clinical prognosis in glioma patients,and to construct and evaluate the model for predicting the prognosis of glioma. Methods The clinical information and GPX expression of 663 patients,including 153 patients of glioblastoma(GBM)and 510 patients of low-grade glioma(LGG),were obtained from The Cancer Genome Atlas(TCGA)database.The relationship between GPX expression and patient survival was analyzed. Read More

Acta Neuropathol Commun 2022 05 7;10(1):70. Epub 2022 May 7.

Pathology and Laboratory Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.

Diffusely infiltrative low-grade gliomas (LGG) are primary brain tumours that arise predominantly in the cerebral hemispheres of younger adults. LGG can display either astrocytic or oligodendroglial histology and do not express malignant histological features. Vast majority of LGG are unified by IDH mutations. Read More

Clin Case Rep 2022 Apr 25;10(4):e05781. Epub 2022 Apr 25.

Department of Neurosurgery Tribhuvan University Teaching Hospital Kathmandu Nepal.

Astroblastoma is a rare central nervous system tumor. We reported a case of a 24-year-old Nepalese woman with radiological features mimicking pilocytic astrocytoma which came out to be low-grade astroblastoma in histopathological and immunohistochemistry examination after total excision of the tumor. Read More

Biomed Res Int 2022 18;2022:4919111. Epub 2022 Apr 18.

The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

The prognostic and therapeutic implications in diffuse gliomas are still challenging. In this study, we first performed an integrative framework to infer the clonal status of mutations in glioblastomas (GBMs) and low-grade gliomas (LGGs) by using exome sequencing data from TCGA and observed both clonal and subclonal mutations for most mutant genes. Based on the clonal status of a given gene, we systematically investigated its prognostic value in GBM and LGG, respectively. Read More

IEEE Trans Biomed Eng 2022 Apr 29;PP. Epub 2022 Apr 29.

Objective: Objective: Accurate identification of surgical margins in brain tumors is of significant prognostic importance. Despite the availability of methods such as 5-ALA and image guidance, recognizing tumor boundary is highly subjective, dependant on recognizing subtle changes in tissue characteristics including texture and color to aid distinction.

Method: Design and development of a semi-automated system integrated with MEMS-based electromechanical sensors to enable an objective and reliable method of distinguishing tumors from normal brain tissue. Read More

Neurol Clin 2022 05 31;40(2):437-453. Epub 2022 Mar 31.

Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue CSC K3/803, Madison, WI 53792, USA. Electronic address:

Gliomas are the most common intrinsic brain tumor in adults. Although maximal tumor resection improves survival, this must be balanced with preservation of neurologic function. Technological advancements have greatly expanded our ability to safely maximize tumor resection and design innovative therapeutic trials that take advantage of intracavitary delivery of therapeutic agents after resection. Read More

J Child Neurol 2022 May 21;37(6):534-540. Epub 2022 Apr 21.

Postgraduation Program in Biotechnology Applied in Health of Children and Adolescent of Faculdades Pequeno Príncipe, 245143Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Paraná, Brazil.

Background: Embryonic stem cell markers, such as SOX2, NANOG, and OCT4, are transcription factors expressed in pluripotent stem cells, involved in the mediation of pluripotency and self-renewal. Especially after the discovery of cancer stem cells, these proteins have been associated with several types of neoplasia, including astrocytomas. In the pediatric population, astrocytomas are the most common solid neoplasia and present the highest mortality rates. Read More

Cancer Res Commun 2022 Jan;2(1):1-9

Division of Neuro-Oncology, Vanderbilt-Ingram Cancer Center, Nashville, TN.

Purpose: mutations in low-grade gliomas (LGGs) results in improved survival and DNA hypermethylation compared to wild-type LGGs. -mutant LGGs become hypomethylated during progression. It's uncertain if methylation changes occur during wild-type GBM progression and if the methylome can be reprogrammed. Read More

Cureus 2022 Mar 29;14(3):e23611. Epub 2022 Mar 29.

Pediatric Neurosurgery, King Fahad Medical City/National Neuroscience Institute, Riyadh, SAU.

Objective: This study aimed to assess the operability of thalamic tumors since they are generally considered to be inoperable and to have poor outcomes. Advancements in neuroimaging, neuronavigational technology, and intraoperative neurophysiological monitoring allow accurate planning and safe resection.

Methods: Clinical data and reports of 10 pediatric patients with thalamic tumors were retrieved retrospectively. Read More

CNS Oncol 2022 Apr 6:CNS81. Epub 2022 Apr 6.

Department of Surgery, King Hussein Cancer Center, Amman, 11941, Jordan.

Adult pilocytic astrocytoma is a rare tumor. We aim to contribute to understanding its clinical course and prognosis. We searched our database for patients older than 18 years with pathology-proven pilocytic astrocytoma. Read More

Radiother Oncol 2022 05 31;170:79-88. Epub 2022 Mar 31.

Department of Radiation Oncology, Keck School of Medicine of University of Southern California, Los Angeles, USA.

Postoperative management of lower grade gliomas (grade 2 and 3) is heterogeneous. The American Radium Society's brain malignancies panel systematically reviewed and evaluated the literature to develop consensus guidelines addressing timing of postoperative therapy, monotherapy versus combined modality therapy, type of chemotherapy used with radiotherapy, and radiotherapy dose. Thirty-six studies were included. Read More

PLoS One 2022 1;17(4):e0266466. Epub 2022 Apr 1.

Laboratorio de Biología Molecular, División Patología, Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP), CONICET-GCBA, Hospital de Niños "Dr. Ricardo Gutiérrez", Buenos Aires, Argentina.

Objectives: Tumors of the central nervous system (CNS) are the most common pediatric solid tumors, where low grade (LGG) and high grade gliomas (HGG) represent up to 55% of CNS tumors. Current molecular classification of these tumors results in a more accurate diagnosis and risk stratification, which ultimately enables individualized treatment strategies. Identifying known alterations is a suitable approach, particularly in developing countries, where NGS approaches are not easily accessible. Read More

Front Oncol 2022 9;12:851803. Epub 2022 Mar 9.

University Medical Center (UMC) Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands.

Background: Until 2015, Dutch guidelines recommended follow-up and biopsy rather than surgery as initial care for suspected low-grade gliomas (LGG). Given evidence that surgery could extend patient survival, our center stopped following this guideline on January 1, 2010 and opted for early maximal safe resection of LGG. The effects of early surgery on the ability of patients to work remains little documented. Read More

Childs Nerv Syst 2022 Mar 29. Epub 2022 Mar 29.

Department of Neurological Surgery, Rochester, MN, USA.

Background: Pilocytic astrocytomas are the most common low-grade glioma of the central nervous system that typically occurs in children, and much research has been dedicated to characterizing their molecular features and clinical courses. We provide an overview of the current literature through the use of a bibliometric analysis of the top 100 most cited publications discussing pilocytic astrocytomas.

Methods: We identified the top 100 most cited publications discussing pilocytic astrocytomas. Read More

Cureus 2022 Feb 15;14(2):e22258. Epub 2022 Feb 15.

Neurological Surgery, New Giza University, Cairo, EGY.

Background: Cerebellar pilocytic astrocytoma (PCA) is one of the few CNS tumors that can be cured with gross-total removal (GTR). In this series, we had 39 patients diagnosed with cerebellar PCA, 27 patients (70%) had GTR, and mean follow-up period was 62 months with no tumor recurrence.

Objective: To assess the long-term outcome of childhood cerebellar PCA treated at our institute during the period 2000-2020 and to highlight our surgical protocol. Read More