6,859 results match your criteria Low Vision Therapy


Patterns of medication use and adherence to medications among residents in the elderly homes.

Authors:
Magda Algameel

Pak J Med Sci 2020 May-Jun;36(4):729-734

Dr. Magda Algameel, Nursing Department, College of Applied Medical Science, Prince Sattam Bin Abdulaziz University, KSA, Wadi Al-Dawasser 11991, Saudi Arabia.

Objective: To evaluate health care related to medication regimens among institutionalized elders in Damanhour, Beheira Governate, Egypt.

Methods: A prospective, multi-centered, observational study was conducted in the two elderly residential homes in Damanhour between March and May 2017. A questionnaire was developed and validated to test for elderly socio-economic, chronic diseases, current therapy adherence, vaccination history and patient education. Read More

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http://dx.doi.org/10.12669/pjms.36.4.1923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260901PMC

Compensatory Cross-Modal Plasticity Persists After Sight Restoration.

Front Neurosci 2020 12;14:291. Epub 2020 May 12.

Department of Ophthalmology, Center for Advanced Retinal and Ocular Therapeutics, University of Pennsylvania, Philadelphia, PA, United States.

Sensory deprivation prompts extensive structural and functional reorganizations of the cortex resulting in the occupation of space for the lost sense by the intact sensory systems. This process, known as cross-modal plasticity, has been widely studied in individuals with vision or hearing loss. However, little is known on the neuroplastic changes in restoring the deprived sense. Read More

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http://dx.doi.org/10.3389/fnins.2020.00291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235304PMC

Two-year interim safety results of the 0.2 µg/day fluocinolone acetonide intravitreal implant for the treatment of diabetic macular oedema: the observational PALADIN study.

Br J Ophthalmol 2020 May 27. Epub 2020 May 27.

Alimera Sciences, Alpharetta, Georgia, USA.

Background: The 0.2 µg/day fluocinolone acetonide (FAc) implant delivers continuous, low-dose, intravitreal corticosteroid for the treatment of diabetic macular oedema (DMO). This ongoing, 3-year, observational clinical trial provides long-term, 'real-world' safety results for the FAc implant in DMO. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315984DOI Listing

Primary Vitreoretinal Lymphoma in HIV Infection.

Ocul Immunol Inflamm 2020 May 26:1-7. Epub 2020 May 26.

Eye and Vision Health, Flinders University, Adelaide, Australia.

: To describe the epidemiology, clinical characteristics, diagnosis and treatment of human immunodeficiency virus (HIV)-related primary vitreoretinal lymphoma (PVRL).: Narrative literature review.: HIV-related PVRL occurs in persons who are relatively young and generally have very low CD4+ T-cell counts. Read More

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http://dx.doi.org/10.1080/09273948.2020.1751856DOI Listing

Improved adherence and treatment outcomes with an engaging, personalized digital therapeutic in amblyopia.

Sci Rep 2020 May 20;10(1):8328. Epub 2020 May 20.

Luminopia, Inc., Cambridge, MA, 02139, USA.

Given the prevalence of poor adherence to therapy and the biases of self-reporting across healthcare, we hypothesized that an engaging, personalized therapy may improve adherence and treatment outcomes in the home. We tested this hypothesis in the initial indication of amblyopia, a neurodevelopmental disorder for which available treatments are limited by low adherence. We designed a novel digital therapeutic that modifies patient-selected cinematic content in real-time into therapeutic visual input, while objectively monitoring adherence. Read More

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http://dx.doi.org/10.1038/s41598-020-65234-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239850PMC

Patient-Reported Outcomes, Physician-Reported Toxicities, and Treatment Outcomes in a Modern Cohort of Patients with Sinonasal Cancer Treated Using Proton Beam Therapy.

Radiother Oncol 2020 May 14. Epub 2020 May 14.

The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Houston, Texas. Electronic address:

Background And Purpose: To report on the physician-assessed toxicities (PATs) and patient-reported outcomes (PROs) in a prospective cohort of patients treated using proton beam therapy (PBT).

Methods And Materials: From 2011-2019, PBT-treated patients with a sinonasal malignancy were enrolled with a primary endpoint of toxicity assessment. PATs and PROs were assessed at baseline, acute (during PBT), subacute (within 90 days after PBT), and chronic time-points. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.05.007DOI Listing

Multiple drug delivery from the drug-implants-laden silicone contact lens: Addressing the issue of burst drug release.

Mater Sci Eng C Mater Biol Appl 2020 Jul 23;112:110885. Epub 2020 Mar 23.

Department of Chemical Engineering and Department of Anesthesiology, University of Florida, Gainesville, FL 32611, USA.

A fixed combination of bimatoprost/timolol eye drop solution is used to manage the elevated intra-ocular pressure in glaucoma patients, including individuals whose condition is poorly controlled by monotherapy. Eye drop solutions are generally given in high dose, due to poor ocular bioavailability. The high ocular dose of bimatoprost and timolol lead to hyperaemia and systemic cardiac side effects respectively. Read More

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http://dx.doi.org/10.1016/j.msec.2020.110885DOI Listing

Loteprednol Etabonate for the Treatment of Dry Eye Disease: A Literature Review.

J Ocul Pharmacol Ther 2020 May 8. Epub 2020 May 8.

Northwest Eye Surgeons, Seattle, Washington, USA.

Dry eye disease (DED) is a common ocular condition that can impair vision and may adversely impact quality of life. Due to the inflammatory nature of this disorder, topical corticosteroids are an effective treatment option, particularly for moderate-to-severe DED when first-line treatments, such as ocular lubricants, are insufficient. Loteprednol etabonate (LE) is a retrometabolically designed corticosteroid with a low propensity to cause corticosteroid-related adverse effects, such as elevated intraocular pressure (IOP). Read More

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http://dx.doi.org/10.1089/jop.2020.0014DOI Listing
May 2020
1.420 Impact Factor

Executive function as a mediating factor between visual acuity and postural stability in cognitively healthy adults and adults with Alzheimer's dementia.

Arch Gerontol Geriatr 2020 Apr 19;89:104078. Epub 2020 Apr 19.

École d'optométrie, Université de Montréal, Montreal, Quebec, Canada.

Background: Falls in older adults, notably those with Alzheimer's dementia (AD), are prevalent. Vision and balance impairments are prominent falls risk factors in older adults. However, recent literature in the cognitively impaired suggests that executive function (EF) is important for falls risk assessments. Read More

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http://dx.doi.org/10.1016/j.archger.2020.104078DOI Listing

Diffusion Magnetic Resonance Imaging Phenotypes Predict Overall Survival Benefit From Bevacizumab or Surgery in Recurrent Glioblastoma With Large Tumor Burden.

Neurosurgery 2020 May 4. Epub 2020 May 4.

UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

Background: Diffusion magnetic resonance (MR) characteristics are a predictive imaging biomarker for survival benefit in recurrent glioblastoma treated with anti-vascular endothelial growth factor (VEGF) therapy; however, its use in large volume recurrence has not been evaluated.

Objective: To determine if diffusion MR characteristics can predict survival outcomes in patients with large volume recurrent glioblastoma treated with bevacizumab or repeat resection.

Methods: A total of 32 patients with large volume (>20 cc or > 3. Read More

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http://dx.doi.org/10.1093/neuros/nyaa135DOI Listing

A novel homozygous c.67C>T variant in retinol binding protein 4 (RBP4) associated with retinitis pigmentosa and childhood acne vulgaris.

Ophthalmic Genet 2020 Apr 23:1-5. Epub 2020 Apr 23.

Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

: The retinol binding protein 4 (RBP4) is essential in delivering retinol to the retinal pigment epithelium and normal functioning of the visual cycle. Homozygous mutations in the RBP4 gene lead to severe retinitis pigmentosa that is phenotypically indistinguishable from retinitis pigmentosa caused by other recessive mutations.: Case Report. Read More

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http://dx.doi.org/10.1080/13816810.2020.1755985DOI Listing

Xentry-Gap19 inhibits Connexin43 hemichannel opening especially during hypoxic injury.

Drug Deliv Transl Res 2020 Jun;10(3):751-765

Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.

Hypoxic injury results in cell death, tissue damage and activation of inflammatory pathways. This is mediated by pathological Connexin43 (Cx43) hemichannel (HC) opening resulting in osmotic and ionic imbalances as well as cytokine production perpetuating the inflammatory environment. Gap19 is an intracellularly acting Cx43 mimetic peptide that blocks HC opening and thus promotes cell survival. Read More

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http://dx.doi.org/10.1007/s13346-020-00763-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223318PMC

Immune-Related Oral, Otologic, and Ocular Adverse Events.

Adv Exp Med Biol 2020 ;1244:295-307

Department of Head and Neck Surgery, Division of Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Emerging immunotherapy agents, such as immune checkpoint inhibitors, have shown remarkable promise in the treatment of various malignancies. These drugs selectively target different steps in the immune response cascade to upregulate the body's normal response to cancer. Due to the novelty of these therapeutic agents, their toxicity profile is less well understood. Read More

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http://dx.doi.org/10.1007/978-3-030-41008-7_17DOI Listing
January 2020

Sonographic Clue in Non-traumatic Carotid-cavernous Fistula: Report of a Case and Literature Review.

Acta Neurol Taiwan 2020 Mar;29(1):18-23

Department of Neurology, China Medical University Hospital, Taichung, Taiwan.

Background: Failure to recognize a carotid-cavernous fistula (CCF) promptly may lead to worse prognosis due to a setback in providing proper treatment. To promote early diagnosis of non-traumatic CCF, we report a case with classic clinical symptoms and signs that was diagnosed and followed up with carotid Doppler sonography (CDS) and transcranial color-coded duplex (TCD).

Case Report: A 45-year-old woman developed an intermittent headache, pulsatile tinnitus, and double vision sequentially within ten days. Read More

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Reversibility of visual field defects through induction of brain plasticity: vision restoration, recovery and rehabilitation using alternating current stimulation.

Neural Regen Res 2020 Oct;15(10):1799-1806

Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University of Magdeburg, Magdeburg; Department of Clinical Neurophysiology, University Medical Center Göttingen, Göttingen, Germany.

For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is low. Nevertheless, there is always some potential for partial recovery of the visual field defect that can be achieved through induction of neuroplasticity. Neuroplasticity refers to the ability of the brain to change its own functional architecture by modulating synaptic efficacy. Read More

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http://dx.doi.org/10.4103/1673-5374.280302DOI Listing
October 2020

Monitoring progression of retinitis pigmentosa: current recommendations and recent advances.

Expert Opin Orphan Drugs 2020 2;8(2-3):67-78. Epub 2020 Mar 2.

Oxford Eye Hospital and Nuffield Department of Clinical Neurosciences, Oxford University, The John Radcliffe Hospital, West Wing, Oxford OX3 9DU, United Kingdom, +44 1865 228974.

Introduction: Retinitis pigmentosa (RP) is the most common form of inherited retinal degenerations with an estimated prevalence of 1 in 4,000 and more than 1 million individuals affected worldwide. With the introduction of the first retinal gene therapy in 2017 the importance of understanding the mechanisms of retinal degeneration and its natural progression has shifted from being of academic interest to being of pivotal for the development of new therapies.

Areas Covered: This review covers standard and innovative diagnostic techniques and complementary examinations needed for the evaluation and treatment of RP. Read More

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http://dx.doi.org/10.1080/21678707.2020.1735352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104334PMC

Intercellular Trafficking of Gold Nanostars in Uveal Melanoma Cells for Plasmonic Photothermal Therapy.

Nanomaterials (Basel) 2020 Mar 24;10(3). Epub 2020 Mar 24.

Departamento de Química Física, Universidad Complutense de Madrid, Avenida Complutense s/n, 28040 Madrid, Spain.

Efficient plasmonic photothermal therapies (PPTTs) using non-harmful pulse laser irradiation at the near-infrared (NIR) are a highly sought goal in nanomedicine. These therapies rely on the use of plasmonic nanostructures to kill cancer cells while minimizing the applied laser power density. Cancer cells have an unsettled capacity to uptake, retain, release, and re-uptake gold nanoparticles, thus offering enormous versatility for research. Read More

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http://dx.doi.org/10.3390/nano10030590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153714PMC

Intravitreal Aflibercept versus Laser Photocoagulation in Asian Patients with Diabetic Macular Edema: The VIVID-East Study.

Clin Ophthalmol 2020 9;14:741-750. Epub 2020 Mar 9.

University Hospital of Tübingen, Tübingen, Germany.

Purpose: The prevalence of diabetes and diabetes-related complications, including diabetic macular edema (DME), is increasing in Asia and worldwide.

Methods: VIVID-East was a 12-month, double-masked, randomized, active-controlled, Phase 3 trial (NCT01783886) enrolling adult patients (aged ≥18 years) with DME at 25 centers across China, Hong Kong, Republic of Korea, and Russia. Eyes were randomized 1:1:1 to 2 mg intravitreal aflibercept (IVT-AFL) every 4 weeks (2q4; N=127), 2 mg IVT-AFL every 8 weeks (after 5 initial monthly doses from baseline to week 16) with sham injections on nontreatment visits (2q8; N=127), or macular laser photocoagulation at baseline and sham injections at every visit (laser control group; N=124). Read More

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http://dx.doi.org/10.2147/OPTH.S235267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069586PMC

Occupational Therapy Practice Guidelines for Older Adults With Low Vision.

Am J Occup Ther 2020 Mar/Apr;74(2):7402397010p1-7402397010p23

Stacy Smallfield, DrOT, OTR/L, BCG, FAOTA, is Associate Professor of Occupational Therapy and Medicine and Assistant Director of Entry-Level Programs, Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO.

Importance: The aging of the population is generating increased demand for occupational therapy practitioners to address the occupational performance of those experiencing low vision.

Objective: This Practice Guideline, which is informed by systematic reviews on interventions for older adults with low vision, is meant to serve as a reference for occupational therapy practitioners to guide best practice in service delivery, improve quality of care, enhance consumer satisfaction, and justify occupational therapy services to external stakeholders. Interventions included in this guideline address performance of activities of daily living (ADLs) and instrumental activities of daily living (IADLs), reading, and leisure and social participation. Read More

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http://dx.doi.org/10.5014/ajot.2020.742003DOI Listing

Occupational Therapy Interventions for Older Adults With Low Vision.

Am J Occup Ther 2020 Mar/Apr;74(2):7402390010p1-7402390010p5

Jennifer Kaldenberg, DrPH, MSA, OTR/L, SCLV, FAOTA, is Clinical Assistant Professor of Occupational Therapy, Boston University, College of Health and Rehabilitation Sciences: Sargent College, Boston, MA.

Evidence Connection articles provide clinical application of systematic reviews developed in conjunction with the American Occupational Therapy Association's (AOTA's) Evidence-Based Practice Project. Findings from the systematic review of occupational therapy for older adults with low vision were published in the January/February 2020 issue of the American Journal of Occupational Therapy (AJOT) and in AOTA's Occupational Therapy Practice Guidelines for Older Adults With Low Vision, published in the March/April 2020 issue of AJOT. In this article, we describe a case report of an older adult with low vision who was referred to outpatient occupational therapy services because of a recent progression of her age-related macular degeneration that led to a decline in functional independence. Read More

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http://dx.doi.org/10.5014/ajot.2020.742004DOI Listing

Occlusion for stimulus deprivation amblyopia.

Cochrane Database Syst Rev 2020 03 23;3:CD005136. Epub 2020 Mar 23.

Royal Victoria Infirmary, Department of Ophthalmology, Claremont Wing, Queen Victoria Road, Newcastle upon Tyne, UK, NE1 4LP.

Background: Stimulus deprivation amblyopia (SDA) develops due to an obstruction to the passage of light secondary to a condition such as cataract. The obstruction prevents formation of a clear image on the retina. SDA can be resistant to treatment, leading to poor visual prognosis. Read More

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http://dx.doi.org/10.1002/14651858.CD005136.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089638PMC

ube3d, a New Gene Associated with Age-Related Macular Degeneration, Induces Functional Changes in Both In Vivo and In Vitro Studies.

Mol Ther Nucleic Acids 2020 Jun 28;20:217-230. Epub 2020 Feb 28.

Department of Ophthalmology, Peking University People's Hospital, Beijing 100044, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Peking University People's Hospital, Beijing 100044, China; Xiamen Eye Centre of Xiamen University & Eye Institute of Xiamen University, Xiamen, Fujian 361000, China. Electronic address:

Neovascular age-related macular degeneration (AMD) is characterized by the formation of choroidal neovascularization, which is responsible for more than 80% of cases of severe vision loss. Ubiquitin protein ligase E3D (UBE3D) gene missense has been proven to be associated with neovascular AMD in the East Asian population based on our previous study. In vivo, we explored the role of ube3d in eye development and the mechanisms underlying the development of neovascular AMD in a zebrafish model. Read More

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http://dx.doi.org/10.1016/j.omtn.2020.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090285PMC

Lamotrigine add-on therapy for drug-resistant focal epilepsy.

Cochrane Database Syst Rev 2020 03 20;3:CD001909. Epub 2020 Mar 20.

Institute of Translational Medicine, University of Liverpool, Department of Molecular and Clinical Pharmacology, Clinical Sciences Centre for Research and Education, Lower Lane, Liverpool, UK, L9 7LJ.

Background: This is an updated version of the Cochrane Review previously published in 2016. Epilepsy is a common neurological disorder, affecting 0.5% to 1% of the population. Read More

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http://dx.doi.org/10.1002/14651858.CD001909.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083514PMC

Intense pulsed light (IPL) therapy for the treatment of meibomian gland dysfunction.

Cochrane Database Syst Rev 2020 03 18;3:CD013559. Epub 2020 Mar 18.

The University of Melbourne, Department of Optometry and Vision Sciences, Parkville, Australia.

Background: Meibomian gland dysfunction (MGD) is the major cause of evaporative dry eye disease, which is the more prevalent form of dry eye disease. Intense pulsed light (IPL) therapy, involving treatment of the skin near the eyelids, has emerged as a potential treatment for MGD.

Objectives: To evaluate the effectiveness and safety of intense pulsed light (IPL) for the management dry eye disease resulting from meibomian gland dysfunction (MGD). Read More

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http://dx.doi.org/10.1002/14651858.CD013559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077992PMC

[The Bardet-Biedl Syndrome - Diagnosis and Follow-up].

Klin Monbl Augenheilkd 2020 Mar 17;237(3):239-247. Epub 2020 Mar 17.

Senckenberg Zentrum für Humangenetik, Frankfurt am Main.

The Bardet-Biedl syndrome (BBS) is a rare inherited ciliopathy, which is accompanied by retinal disease, i.e. rod-cone dystrophy (retinitis pigmentosa, RP) and other symptoms, especially truncal obesity, polydactyly, renal abnormalities as well as reduced intelligence or learning difficulties. Read More

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http://dx.doi.org/10.1055/a-1118-3748DOI Listing

Application of protection motivation theory to clinical trial enrolment for pediatric chronic conditions.

BMC Pediatr 2020 Mar 16;20(1):123. Epub 2020 Mar 16.

Faculty of Health Sciences, Simon Fraser University, Blusson Hall 11328, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.

Background: Parents of children living with chronic but manageable conditions hope for improved therapies or cures, including Advanced Therapy Medicinal Products (ATMPs). Multiple pediatric clinical trials for ATMPs are underway, but the risk profile of ATMPs for chronic conditions is largely unknown and likely different than for terminal pediatric illnesses. Applying Protection Motivation Theory modified to the context of pediatric ATMP clinical trial enrollment, our study analyses information needs of parents of children living with chronic manageable conditions: Type 1 Diabetes (T1D) or Inherited Retinal Diseases (IRD). Read More

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http://dx.doi.org/10.1186/s12887-020-2014-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075002PMC

Portable Motion-Analysis Device for Upper-Limb Research, Assessment, and Rehabilitation in Non-Laboratory Settings.

IEEE J Transl Eng Health Med 2019 13;7:2800314. Epub 2019 Nov 13.

1Electrical & Computer Engineering and Physics DepartmentNortheastern UniversityBostonMA02115USA.

This study presents the design and feasibility testing of an interactive portable motion-analysis device for the assessment of upper-limb motor functions in clinical and home settings. The device engages subjects to perform tasks that imitate activities of daily living, e.g. Read More

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http://dx.doi.org/10.1109/JTEHM.2019.2953257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889943PMC
November 2019

Regression of macular edema with topical brinzolamide and nepafenac alone and identification of a novel gyrate atrophy mutation.

Arq Bras Oftalmol 2020 Mar-Apr;83(2):149-152

Department of Ophthalmology, Ankara Numune Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Gyrate atrophy is a rare metabolic autosomal recessive disorder caused by ornithine aminotransferase enzyme deficiency that leads to characteristic progressive, degenerative chorioretinal findings. Patients complain mostly of low vision, night blindness, and peripheral vision loss. Posterior subcapsular cataract, myopia, choroid neovascularization, and intraretinal cysts may be accompanying factors related to vision loss. Read More

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http://dx.doi.org/10.5935/0004-2749.20200028DOI Listing

Making Blind Children See: Impact of Correcting Moderate and Severe Visual Impairment in Schools for the Blind.

Middle East Afr J Ophthalmol 2019 Oct-Dec;26(4):216-222. Epub 2020 Jan 29.

Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: Childhood blindness and visual impairment accounts for enormous burden of blindness. This study aimed to analyze the causes of severe visual impairment and blindness in students attending schools for the blind and to identify those whose vision could be improved by optical aids. On dispensing such aids, the study also aimed to analyze the improvement in their vision function. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_111_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034146PMC

Near Point of Convergence Deficits and Treatment Following Concussion: A Systematic Review.

J Sport Rehabil 2020 Mar 4:1-15. Epub 2020 Mar 4.

Context: Convergence dysfunction following concussion is common. Near point of convergence (NPC) is a quick and easy assessment that may detect oculomotor dysfunction such as convergence insufficiency (CI), but NPC measurements are rarely reported. Convergence dysfunction is treatable in otherwise healthy patients; the effectiveness of oculomotor therapy following concussion is unclear. Read More

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http://dx.doi.org/10.1123/jsr.2019-0428DOI Listing

Incidence and Predictors of Cognitive Frailty Among Older Adults: A Community-based Longitudinal Study.

Int J Environ Res Public Health 2020 02 28;17(5). Epub 2020 Feb 28.

Dietetics Programme and Centre for Healthy Ageing and Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.

(1) Background: Cognitive frailty (CF) is the simultaneous presence of physical frailty and cognitive impairment with an increased risk of dementia. Considering that the risk factors of CF are mostly elucidated from cross-sectional studies, we conducted a community-based longitudinal study to determine the incidence and the predictors of CF among Malaysian older adults.; (2) Methods: Out of 490 older adults participating in the Malaysian Towards Useful Aging (TUA) study, 282 were successfully followed-up at five-years for an analysis of the CF incidence. Read More

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http://dx.doi.org/10.3390/ijerph17051547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084438PMC
February 2020

Global Retinoblastoma Presentation and Analysis by National Income Level.

Authors:
Ido Didi Fabian Elhassan Abdallah Shehu U Abdullahi Rula A Abdulqader Sahadatou Adamou Boubacar Dupe S Ademola-Popoola Adedayo Adio Armin R Afshar Priyanka Aggarwal Ada E Aghaji Alia Ahmad Marliyanti N R Akib Lamis Al Harby Mouroge H Al Ani Aygun Alakbarova Silvia Alarcón Portabella Safaa A F Al-Badri Ana Patricia A Alcasabas Saad A Al-Dahmash Amanda Alejos Ernesto Alemany-Rubio Amadou I Alfa Bio Yvania Alfonso Carreras Christiane Al-Haddad Hamoud H Y Al-Hussaini Amany M Ali Donjeta B Alia Mazin F Al-Jadiry Usama Al-Jumaly Hind M Alkatan Charlotta All-Eriksson Ali A R M Al-Mafrachi Argentino A Almeida Khalifa M Alsawidi Athar A S M Al-Shaheen Entissar H Al-Shammary Primawita O Amiruddin Romanzo Antonino Nicholas J Astbury Hatice T Atalay La-Ongsri Atchaneeyasakul Rose Atsiaya Taweevat Attaseth Than H Aung Silvia Ayala Baglan Baizakova Julia Balaguer Ruhengiz Balayeva Walentyna Balwierz Honorio Barranco Covadonga Bascaran Maja Beck Popovic Raquel Benavides Sarra Benmiloud Nissrine Bennani Guebessi Rokia C Berete Jesse L Berry Anirban Bhaduri Sunil Bhat Shelley J Biddulph Eva M Biewald Nadia Bobrova Marianna Boehme H C Boldt Maria Teresa B C Bonanomi Norbert Bornfeld Gabrielle C Bouda Hédi Bouguila Amaria Boumedane Rachel C Brennan Bénédicte G Brichard Jassada Buaboonnam Patricia Calderón-Sotelo Doris A Calle Jara Jayne E Camuglia Miriam R Cano Michael Capra Nathalie Cassoux Guilherme Castela Luis Castillo Jaume Català-Mora Guillermo L Chantada Shabana Chaudhry Sonal S Chaugule Argudit Chauhan Bhavna Chawla Violeta S Chernodrinska Faraja S Chiwanga Tsengelmaa Chuluunbat Krzysztof Cieslik Ruellyn L Cockcroft Codruta Comsa Zelia M Correa Maria G Correa Llano Timothy W Corson Kristin E Cowan-Lyn Monika Csóka Xuehao Cui Isac V Da Gama Wantanee Dangboon Anirban Das Sima Das Jacquelyn M Davanzo Alan Davidson Patrick De Potter Karina Q Delgado Hakan Demirci Laurence Desjardins Rosdali Y Diaz Coronado Helen Dimaras Andrew J Dodgshun Craig Donaldson Carla R Donato Macedo Monica D Dragomir Yi Du Magritha Du Bruyn Kemala S Edison I Wayan Eka Sutyawan Asmaa El Kettani Amal M Elbahi James E Elder Dina Elgalaly Alaa M Elhaddad Moawia M Ali Elhassan Mahmoud M Elzembely Vera A Essuman Ted Grimbert A Evina Zehra Fadoo Adriana C Fandiño Mohammad Faranoush Oluyemi Fasina Delia D P G Fernández Ana Fernández-Teijeiro Allen Foster Shahar Frenkel Ligia D Fu Soad L Fuentes-Alabi Brenda L Gallie Moira Gandiwa Juan L Garcia David García Aldana Pascale Y Gassant Jennifer A Geel Fariba Ghassemi Ana V Girón Zelalem Gizachew Marco A Goenz Aaron S Gold Maya Goldberg-Lavid Glen A Gole Nir Gomel Efren Gonzalez Graciela Gonzalez Perez Liudmira González-Rodríguez Henry N Garcia Pacheco Jaime Graells Liz Green Pernille A Gregersen Nathalia D A K Grigorovski Koffi M Guedenon D Sanjeeva Gunasekera Ahmet K Gündüz Himika Gupta Sanjiv Gupta Theodora Hadjistilianou Patrick Hamel Syed A Hamid Norhafizah Hamzah Eric D Hansen J William Harbour M Elizabeth Hartnett Murat Hasanreisoglu Sadiq Hassan Shadab Hassan Stanislava Hederova Jose Hernandez Lorelay Marie Carcamo Hernandez Laila Hessissen Diriba F Hordofa Laura C Huang G B Hubbard Marlies Hummlen Kristina Husakova Allawi N Hussein Al-Janabi Russo Ida Vesna R Ilic Vivekaraj Jairaj Irfan Jeeva Helen Jenkinson Xunda Ji Dong Hyun Jo Kenneth P Johnson William J Johnson Michael M Jones Theophile B Amani Kabesha Rolande L Kabore Swathi Kaliki Abubakar Kalinaki Mehmet Kantar Ling-Yuh Kao Tamar Kardava Rejin Kebudi Tomas Kepak Naama Keren-Froim Zohora J Khan Hussain A Khaqan Phara Khauv Wajiha J Kheir Vikas Khetan Alireza Khodabande Zaza Khotenashvili Jonathan W Kim Jeong Hun Kim Hayyam Kiratli Tero T Kivelä Artur Klett Jess Elio Kosh Komba Palet Dalia Krivaitiene Mariana Kruger Kittisak Kulvichit Mayasari W Kuntorini Alice Kyara Eva S Lachmann Carol P S Lam Geoffrey C Lam Scott A Larson Slobodanka Latinovic Kelly D Laurenti Bao Han A Le Karin Lecuona Amy A Leverant Cairui Li Ben Limbu Quah Boon Long Juan P López Robert M Lukamba Livia Lumbroso Sandra Luna-Fineman Delfitri Lutfi Lesia Lysytsia George N Magrath Amita Mahajan Abdul Rahim Majeed Erika Maka Mayuri Makan Emil K Makimbetov Chatonda Manda Nieves Martín Begue Lauren Mason John O Mason Ibrahim O Matende Miguel Materin Clarissa C D S Mattosinho Marchelo Matua Ismail Mayet Freddy B Mbumba John D McKenzie Aurora Medina-Sanson Azim Mehrvar Aemero A Mengesha Vikas Menon Gary John V D Mercado Marilyn B Mets Edoardo Midena Divyansh K C Mishra Furahini G Mndeme Ahmed A Mohamedani Mona T Mohammad Annette C Moll Margarita M Montero Rosa A Morales Claude Moreira Prithvi Mruthyunjaya Mchikirwa S Msina Gerald Msukwa Sangeeta S Mudaliar Kangwa I Muma Francis L Munier Gabriela Murgoi Timothy G Murray Kareem O Musa Asma Mushtaq Hamzah Mustak Okwen M Muyen Gita Naidu Akshay Gopinathan Nair Larisa Naumenko Paule Aïda Ndoye Roth Yetty M Nency Vladimir Neroev Hang Ngo Rosa M Nieves Marina Nikitovic Elizabeth D Nkanga Henry Nkumbe Murtuza Nuruddin Mutale Nyaywa Ghislaine Obono-Obiang Ngozi C Oguego Andrzej Olechowski Scott C N Oliver Peter Osei-Bonsu Diego Ossandon Manuel A Paez-Escamilla Halimah Pagarra Sally L Painter Vivian Paintsil Luisa Paiva Bikramjit P Pal Mahesh Shanmugam Palanivelu Ruzanna Papyan Raffaele Parrozzani Manoj Parulekar Claudia R Pascual Morales Katherine E Paton Katarzyna Pawinska-Wasikowska Jacob Pe'er Armando Peña Sanja Peric Chau T M Pham Remezo Philbert David A Plager Pavel Pochop Rodrigo A Polania Vladimir G Polyakov Manca T Pompe Jonathan J Pons Daphna Prat Vireak Prom Ignatius Purwanto Ali O Qadir Seema Qayyum Jiang Qian Ardizal Rahman Salman Rahman Jamalia Rahmat Purnima Rajkarnikar Rajesh Ramanjulu Aparna Ramasubramanian Marco A Ramirez-Ortiz Léa Raobela Riffat Rashid M Ashwin Reddy Ehud Reich Lorna A Renner David Reynders Dahiru Ribadu Mussagy M Riheia Petra Ritter-Sovinz Duangnate Rojanaporn Livia Romero Soma R Roy Raya H Saab Svetlana Saakyan Ahmed H Sabhan Mandeep S Sagoo Azza M A Said Rohit Saiju Beatriz Salas Sonsoles San Román Pacheco Gissela L Sánchez Phayvanh Sayalith Trish A Scanlan Amy C Schefler Judy Schoeman Ahad Sedaghat Stefan Seregard Rachna Seth Ankoor S Shah Shawkat A Shakoor Manoj K Sharma Sadik T Sherief Nandan G Shetye Carol L Shields Sorath Noorani Siddiqui Sidi Sidi Cheikh Sónia Silva Arun D Singh Niharika Singh Usha Singh Penny Singha Rita S Sitorus Alison H Skalet Hendrian D Soebagjo Tetyana Sorochynska Grace Ssali Andrew W Stacey Sandra E Staffieri Erin D Stahl Christina Stathopoulos Branka Stirn Kranjc David K Stones Caron Strahlendorf Maria Estela Coleoni Suarez Sadia Sultana Xiantao Sun Meryl Sundy Rosanne Superstein Eddy Supriyadi Supawan Surukrattanaskul Shigenobu Suzuki Karel Svojgr Fatoumata Sylla Gevorg Tamamyan Deborah Tan Alketa Tandili Fanny F Tarrillo Leiva Maryam Tashvighi Bekim Tateshi Edi S Tehuteru Luiz F Teixeira Kok Hoi Teh Tuyisabe Theophile Helen Toledano Doan L Trang Fousseyni Traoré Sumalin Trichaiyaporn Samuray Tuncer Harba Tyau-Tyau Ali B Umar Emel Unal Ogul E Uner Steen F Urbak Tatiana L Ushakova Rustam H Usmanov Sandra Valeina Milo van Hoefen Wijsard Adisai Varadisai Liliana Vasquez Leon O Vaughan Nevyana V Veleva-Krasteva Nishant Verma Andi A Victor Maris Viksnins Edwin G Villacís Chafla Vicktoria Vishnevskia-Dai Tushar Vora Antonio E Wachtel Werner Wackernagel Keith Waddell Patricia D Wade Amina H Wali Yi-Zhuo Wang Avery Weiss Matthew W Wilson Amelia D C Wime Atchareeya Wiwatwongwana Damrong Wiwatwongwana Charlotte Wolley Dod Phanthipha Wongwai Daoman Xiang Yishuang Xiao Jason C Yam Huasheng Yang Jenny M Yanga Muhammad A Yaqub Vera A Yarovaya Andrey A Yarovoy Huijing Ye Yacoub A Yousef Putu Yuliawati Arturo M Zapata López Ekhtelbenina Zein Chengyue Zhang Yi Zhang Junyang Zhao Xiaoyu Zheng Katsiaryna Zhilyaeva Nida Zia Othman A O Ziko Marcia Zondervan Richard Bowman

JAMA Oncol 2020 Feb 27. Epub 2020 Feb 27.

International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Read More

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http://dx.doi.org/10.1001/jamaoncol.2019.6716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047856PMC
February 2020

The Complexity of Making a Diagnosis.

J Dev Behav Pediatr 2020 Apr;41(3):242-244

Developmental-Behavioral Pediatrician, Children's Mercy Kansas City, University of Missouri Kansas City School of Medicine, Kansas City, MO.

Case: Carl is a 12-year-old boy midline, with neurologic malformation, ataxia, bilateral strabismus with presumed residual visual impairment after surgical repair, and intellectual disability. He was referred to developmental-behavioral pediatrics for evaluation of possible autism spectrum disorder (ASD).Carl had a benign prenatal course and was born via spontaneous vaginal delivery at term. Read More

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http://dx.doi.org/10.1097/DBP.0000000000000792DOI Listing

Occupational Therapy Interventions to Improve Reading Performance of Older Adults With Low Vision: A Systematic Review.

Am J Occup Ther 2020 Jan/Feb;74(1):7401185030p1-7401185030p18

Jennifer Kaldenberg, DrPH, MSA, OTR/L, SCLV, FAOTA, is Clinical Assistant Professor of Occupational Therapy, Boston University, College of Health and Rehabilitation Sciences: Sargent College, Boston, MA.

Importance: Low vision affects many older adults and is expected to significantly increase over the next several decades. It has a significant impact on all aspects of daily life, including the reading required for participation in occupations.

Objective: To determine the effectiveness of interventions within the scope of occupational therapy to improve reading required for the performance of occupations by older adults with low vision. Read More

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http://dx.doi.org/10.5014/ajot.2020.038380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018456PMC

Occupational Therapy Interventions Supporting Leisure and Social Participation for Older Adults With Low Vision: A Systematic Review.

Am J Occup Ther 2020 Jan/Feb;74(1):7401185020p1-7401185020p9

Julie Ann Nastasi, ScD, OTD, OTR/L, SCLV, CLA, FAOTA, is Assistant Professor, Department of Occupational Therapy, The University of Scranton, Scranton, PA;

Importance: Evidence supports interventions for social participation for older adults with low vision.

Objective: This systematic review examined the evidence for interventions within the scope of occupational therapy practice to maintain, restore, and improve performance and quality of life in leisure and social participation for older adults with low vision.

Data Sources: MEDLINE, PsycINFO, CINAHL, OTseeker, and the Cochrane Database of Systematic Reviews were searched for articles published from January 2010 to March 2017 that described interventions within the scope of occupational therapy practice for older adults with low vision (mean age 55+). Read More

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http://dx.doi.org/10.5014/ajot.2020.038521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018464PMC

Interventions Within the Scope of Occupational Therapy Practice to Improve Performance of Daily Activities for Older Adults With Low Vision: A Systematic Review.

Am J Occup Ther 2020 Jan/Feb;74(1):7401185010p1-7401185010p18

Megan C. Chang, PhD, OTR/L, is Associate Professor, College of Health and Human Sciences, San Jose State University, San Jose, CA.

Importance: The prevalence of low vision increases with age. Low vision has detrimental effects on older adults' independence.

Objective: To identify the effectiveness of interventions within the scope of occupational therapy practice to maintain, restore, and improve performance in daily activities for older adults with low vision. Read More

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http://dx.doi.org/10.5014/ajot.2020.038372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018463PMC

Occupational Therapy Interventions for People With Low Vision.

Am J Occup Ther 2020 Jan/Feb;74(1):7401170010p1-7401170010p2

Julie Ann Nastasi, ScD, OTD, OTR/L, SCLV, CLA, FAOTA, is Assistant Professor, Department of Occupational Therapy, University of Scranton, Scranton, PA;

The special section in this issue advances research for occupational therapy interventions for people with low vision. Three systematic reviews provide evidence for occupational therapy interventions in the areas of activities of daily living, instrumental activities of daily living, leisure and social participation, and reading. In addition, the special section addresses oculomotor treatment in traumatic brain injury, normative data for the Dynavision, and properties of a ScanCourse. Read More

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http://dx.doi.org/10.5014/ajot.2020.741001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018462PMC

The effects of meclizine on motion sickness revisited.

Br J Clin Pharmacol 2020 Feb 19. Epub 2020 Feb 19.

Department of Clinical Neuroscience, Division of Ophthalmology and Vision, Marianne Bernadotte Centre, Karolinska Institutet, Stockholm, Sweden.

Aims: Antihistamines make up the first line of treatments against motion-sickness. Still, their efficacy and specific mechanism have come into question. The aim of this study was to investigate the effect of meclizine on motion-sensitivity. Read More

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http://dx.doi.org/10.1111/bcp.14257DOI Listing
February 2020

Advanced spheroidal degeneration.

Digit J Ophthalmol 2019 Apr 22;25(4):68-71. Epub 2019 Dec 22.

Department of Ophthalmology, Kasr Al-Ainy Hospitals, Cairo University, Giza, Egypt.

Spheroidal degeneration, involving the cornea and/or the conjunctiva, is characterized by amber-colored homogeneous, translucent spherules in the corneal stroma, Bowman's membrane, and subepithelium. The condition has a higher prevalence in areas with extreme temperatures, low humidity, high wind, and presence of sand. We report the case of a 46-year-old man with a 10-year history of gradual progressive diminution of vision, severe blepharospasm, and photophobia. Read More

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http://dx.doi.org/10.5693/djo.02.2019.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001646PMC

Phase I/II randomized study of proton beam with anti-VEGF for exudative age-related macular degeneration: long-term results.

Eye (Lond) 2020 Feb 13. Epub 2020 Feb 13.

Vitreoretinal Service, Department of Ophthalmology & Vision Science, University of California Davis Eye Center, Sacramento, CA, USA.

Background/objective: To determine if treatment of exudative age-related macular degeneration (eAMD) using proton beam therapy (PBT) combined with intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is safe and effective long term.

Subject/methods: Thirty eyes with newly diagnosed eAMD were enrolled in a phase I/II prospective, sham-controlled double-masked university study. Eyes were randomized 1:1:1-24 GyE, 16 GyE or sham radiation, and treated with three initial monthly intravitreal ranibizumab or bevacizumab. Read More

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http://dx.doi.org/10.1038/s41433-020-0807-2DOI Listing
February 2020

Irrelevant auditory and tactile signals, but not visual signals, interact with the target onset and modulate saccade latencies.

PLoS One 2020 11;15(2):e0221192. Epub 2020 Feb 11.

Institut de Neurosciences de la Timone, UMR 7289, CNRS, Aix-Marseille Université, Marseille, France.

Saccadic eye movements bring events of interest to the center of the retina, enabling detailed visual analysis. This study explored whether irrelevant auditory (experiments A, B & F), visual (C & D) or tactile signals (E & F) delivered around the onset of a visual target modulates saccade latency. Participants were instructed to execute a quick saccade toward a target stepping left or right from a fixation position. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221192PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012454PMC

Diabetes Detection and Communication among Patients Admitted through the Emergency Department of a Public Hospital.

Int J Environ Res Public Health 2020 02 4;17(3). Epub 2020 Feb 4.

Diabetes, Obesity and Metabolism Translational Research Unit, School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.

Early identification/diagnosis of diabetes and frequent monitoring of hyperglycemia reduces hospitalizations and diabetes-related complications. The present study investigated the proportion of older adults coded with diabetes or newly diagnosed during their admissions and assessed discharge summary content for diabetes-related information. The study used electronic data on 4796 individuals aged ≥60 years admitted through the emergency department (ED) of a public hospital from 2017 to 2018 extracted using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM code). Read More

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http://dx.doi.org/10.3390/ijerph17030980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038107PMC
February 2020

Anti-vascular endothelial growth factor for neovascular glaucoma.

Cochrane Database Syst Rev 2020 02 6;2:CD007920. Epub 2020 Feb 6.

IBM Watson Health, Life Sciences, Oncology, & Genomics, Baltimore, Maryland, USA.

Background: Neovascular glaucoma (NVG) is a potentially blinding, secondary glaucoma. It is caused by the formation of abnormal new blood vessels, which prevent normal drainage of aqueous from the anterior segment of the eye. Anti-vascular endothelial growth factor (anti-VEGF) medications are specific inhibitors of the primary mediators of neovascularization. Read More

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http://dx.doi.org/10.1002/14651858.CD007920.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003996PMC
February 2020

Multiple Sclerosis Performance Test: validation of self-administered neuroperformance modules.

Eur J Neurol 2020 May 2;27(5):878-886. Epub 2020 Mar 2.

Biogen, Cambridge, MA, USA.

Background And Purpose: The purpose was to determine the test-retest reliability, practice effects, convergent validity and sensitivity to multiple sclerosis (MS) disability of neuroperformance subtests from the patient self-administered Multiple Sclerosis Performance Test (MSPT) designed to assess low contrast vision (Contrast Sensitivity Test, CST), upper extremity motor function (Manual Dexterity Test, MDT) and lower extremity motor function (Walking Speed Test, WST) and to introduce the concept of regression-based norms to aid clinical interpretation of performance scores using the MSPT cognition test (Processing Speed Test, PST) as an example.

Methods: Substudy 1 assessed test-retest reliability, practice effects and convergent validity of the CST, MDT and WST in 30 MS patients and 30 healthy controls. Substudy 2 examined sensitivity to MS disability in over 600 MS patients as part of their routine clinic assessment. Read More

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http://dx.doi.org/10.1111/ene.14162DOI Listing

Relationship between brain structure and Cerebral Visual Impairment in children with Cerebral Palsy: A systematic review.

Res Dev Disabil 2020 Jan 28;99:103580. Epub 2020 Jan 28.

The University of Queensland, Queensland Cerebral Palsy and Rehabilitation Research Centre, Centre for Children's Health Research, Brisbane, Australia.

Background: Cerebral Visual Impairment (CVI) is very common yet often unrecognised visual dysfunction in children with Cerebral Palsy (CP). Magnetic Resonance Imaging (MRI) is the diagnostic tool in the investigation of brain lesions in children with CP and CVI.

Aim: The aim of this systematic review is to evaluate the relationship between brain structure and CVI, as determined by MRI in children with CP. Read More

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http://dx.doi.org/10.1016/j.ridd.2020.103580DOI Listing
January 2020

Different human resting memory CD4 T cell subsets show similar low inducibility of latent HIV-1 proviruses.

Sci Transl Med 2020 Jan;12(528)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

The latent reservoir of HIV-1 in resting CD4 T cells is a major barrier to cure. It is unclear whether the latent reservoir resides principally in particular subsets of CD4 T cells, a finding that would have implications for understanding its stability and developing curative therapies. Recent work has shown that proliferation of HIV-1-infected CD4 T cells is a major factor in the generation and persistence of the latent reservoir and that latently infected T cells that have clonally expanded in vivo can proliferate in vitro without producing virions. Read More

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http://dx.doi.org/10.1126/scitranslmed.aax6795DOI Listing
January 2020