6,258 results match your criteria Low Vision Therapy


Cerebral Venous Sinus Thrombosis in Systemic Lupus Erythematosus.

Acta Med Indones 2018 Oct;50(4):343-345

Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

A 38-year-old woman presented with general weakness and vaginal bleeding. One month prior, she had been diagnosed with Evans syndrome (haemolytic anemia with positive Coombs test and thrombocytopenia) and was given oral steroid as maintenance therapy. Her serology examination was negative for hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Read More

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October 2018
4 Reads

Update of the evidence based, interdisciplinary guideline for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

The Society for Paediatric Rheumatology (GKJR), Germany.

Background: Uveitis in juvenile idiopathic arthritis (JIAU) is frequently associated with the development of complications and visual loss. Topical corticosteroids are the first line therapy, and disease modifying anti-rheumatic drugs (DMARDs) are commonly used. However, treatment has not been standardized. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.004DOI Listing
December 2018

A Randomized, Controlled Trial of Cyclosporine A Cationic Emulsion in Pediatric Vernal Keratoconjunctivitis: The VEKTIS Study.

Ophthalmology 2018 Dec 26. Epub 2018 Dec 26.

University Hospital Necker Enfants Malades, APHP, and CNRS Unit FR3636, Paris Descartes University, Paris, France. Electronic address:

Background: Vernal keratoconjunctivitis (VKC) is a chronic, allergic, and potentially severe ocular disease affecting children and adolescents that can lead to impaired quality of life (QoL) and loss of vision.

Purpose: This study evaluated the efficacy and safety of an investigational therapy for severe VKC, cyclosporine A cationic emulsion (CsA CE), an oil-in-water emulsion with increased bioavailability versus conventional CsA formulations.

Design: VEKTIS is a phase 3, multicenter, double-masked, vehicle-controlled trial. Read More

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http://dx.doi.org/10.1016/j.ophtha.2018.12.027DOI Listing
December 2018

Visual and somatosensory contributions to infant sitting postural control.

Somatosens Mot Res 2018 Dec 28:1-7. Epub 2018 Dec 28.

b Division of Biomechanics and Research Development and Department of Biomechanics , University of Nebraska at Omaha , Omaha , NE , USA.

There are a limited number of studies that have investigated sitting posture during infancy and the contribution of the sensory systems. The goal of this study was to examine the effects of altered visual and somatosensory signals on infant sitting postural control. Thirteen infants (mean age ± SD, 259. Read More

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http://dx.doi.org/10.1080/08990220.2018.1551203DOI Listing
December 2018
1 Read

The future of integrative health and medicine in Saudi Arabia.

Integr Med Res 2018 Dec 23;7(4):316-321. Epub 2018 Jun 23.

National Center for Complementary and Alternative Medicine, Ministry of Health, Riyadh, Saudi Arabia.

Saudi Arabia is witnessing a healthcare transformation to face the challenges of the increased burden of noncommunicable diseases and to maintain the quality of healthcare services. However, in Saudi Arabia, where low back and neck pain, depressive disorders, migraine, diabetes, and anxiety disorders cause the most disability, a broader way of integrative health approach is needed to foster healthy lives and promote well-being for all ages. In the presence of the advanced modern medicine healthcare system in Saudi Arabia, the traditional medicine healing system is being used by a substantial proportion of Saudis but like a shadow healthcare system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22134220183016
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http://dx.doi.org/10.1016/j.imr.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303372PMC
December 2018
6 Reads

Outcomes After Comprehensive Vision Rehabilitation Using Vision-related Quality of Life Questionnaires: Impact of Vision Impairment and National Eye Institute Visual Functioning Questionnaire.

Optom Vis Sci 2018 Dec 26. Epub 2018 Dec 26.

Lighthouse Guild, New York, New York.

Significance: This research is significant because, although vision-related quality of life (VRQoL) is improved after vision rehabilitation (VR), patients with certain characteristics respond less positively on VRQoL measures, and this should inform future care.

Purpose: The purposes of this study were to evaluate how two VRQoL questionnaires compare in measuring change in patient-reported outcomes after VR and to determine if patient characteristics or occupational therapy (OT) predict higher scores after rehabilitation.

Methods: In a prospective clinical cohort study, 109 patients with low vision completed the Impact of Vision Impairment (IVI) and the National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) before and after VR. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001327DOI Listing
December 2018

Effect of Vision Therapy on Accommodative Lag in Myopic Children: A Randomized Clinical Trial.

Optom Vis Sci 2019 Jan;96(1):17-26

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

Significance: Accommodative dysfunction has been suggested to be related to the development and progression of myopia. Office-based accommodative/vergence therapy (OBAVT) improved accommodative facility in Chinese myopic children, but it is unclear if such improvement has a role in decreasing myopic progression.

Purpose: The purpose of this study was to compare the effects of OBAVT with home reinforcement and office-based placebo therapy (OBPT) as a treatment to improve accommodative functions (i. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001316DOI Listing
January 2019
6 Reads

Long-term efficacy of fractionated conformal radiotherapy for the management of primary optic nerve sheath meningioma.

Br J Ophthalmol 2018 Dec 20. Epub 2018 Dec 20.

Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Background/aim: Fractionated conformal radiotherapy (FCRT) is now used to treat vision-threatening optic nerve sheath meningioma (ONSM), but long-term efficacy and safety data are lacking; the purpose of this study was to assess these key data.

Methods: This is a retrospective chart review with prospective follow-up of adult patients treated with FCRT for primary ONSM at four academic medical centres between 1995 and 2007 with ≥10 years of follow-up after treatment.

Results: 16 patients were identified with a mean post-treatment follow-up of 14. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313135DOI Listing
December 2018

Use of bevacizumab as a single agent or in adjunct with traditional chemotherapy regimens in children with unresectable or progressive low-grade glioma.

Cancer Med 2018 Dec 19. Epub 2018 Dec 19.

Children's Cancer Centre, The Royal Children's Hospital, Melbourne, Victoria, Australia.

In pediatric low-grade gliomas not amenable to complete resection, various chemotherapy regimens are the mainstream of treatment. An excellent overall survival of these patients makes justification of the intensification of chemotherapy difficult and calls for the development of new strategies. Bevacizumab, a humanized monoclonal antibody directed against Vascular endothelial growth factor (VEGF), has been successfully used in combination with irinotecan in a number of adult and pediatric studies and reports. Read More

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http://dx.doi.org/10.1002/cam4.1799DOI Listing
December 2018
1 Read

Chewing Difficulty Should be Included as a Geriatric Syndrome.

Nutrients 2018 Dec 17;10(12). Epub 2018 Dec 17.

Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Recent studies have noted an association between chewing difficulties and frailty. In a pilot survey of primary care needs of older people living in the community using automated methods, we examined the prevalence of chewing difficulties and the cross-sectional association with other geriatric syndromes, chronic diseases, and the use of hospital services. A brief multi-domain geriatric assessment was administered to 2259 men and women using a mobile device, the data uploaded to the cloud and analyzed. Read More

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http://dx.doi.org/10.3390/nu10121997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315631PMC
December 2018

A Randomized Trial to Evaluate the Effect of Toric Versus Spherical Contact Lenses on Vision and Eyestrain.

Eye Contact Lens 2019 Jan;45(1):28-33

The Ocular Surface Institute (D.A.B., D.R.P.), University of Houston College of Optometry, Houston, TX; University of Alabama at Birmingham School of Optometry (S.M.C., J.J.N.), Birmingham, AL; The Ohio State University College of Optometry (K.M.B.), Columbus, OH; Alcon Laboratories (J.H.M.), Fort Worth, TX; Department of Biomedical Engineering (S.H.S.), University of Rochester, Rochester, NY; and Johnson & Johnson Vision Care, Inc (B.K.L., K.O.L.), Jacksonville, FL.

Objectives: To compare the effect of toric versus spherical soft contact lenses on objective measures of visual performance using visual acuity and electromyography of the orbicularis oculi muscle.

Methods: Current soft contact lens wearers with -0.75 to -1. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319569PMC
January 2019

Impact of a Social Worker in a Glaucoma Eye Care Service: A Prospective Study.

Health Soc Work 2018 Dec 15. Epub 2018 Dec 15.

Lisa A. Hark, PhD, RD, is professor of ophthalmic sciences, administrative director of Jonas Children's Vision Care, and director of the Clinical Trials Unit, Irving Medical Center, Columbia University, 635 West 165th Street, Mailbox 10, New York, NY 10032; e-mail: Malika Madhava, BS; Anjithaa Radakrishnan, BS, are medical students, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia. Catherine Anderson-Quiñones, BM, is study coordinator, Glaucoma Research Center, Wills Eye Hospital, Philadelphia. Debra Robinson, MSS, LSW, is a medical social worker, Generations Life Care, Chadds Ford, PA. Jennifer Adeghate, MD, is resident physician, Department of Ophthalmology, Weill Cornell Medical Center, New York. Stephen Silva, MD, is orthopedic resident (surgery), Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia. Tingting Zhan, PhD, is a biostatistician, Department of Pharmacology and Experimental Therapeutics, Division of Biostatistics, Thomas Jefferson University, Philadelphia. Tomilade Adepoju, MD, is medical doctor and ophthalmology resident, Department of Ophthalmology, Nassau University Medical Center, East Meadow, NY. Yatee Dave, BA, is a medical student, Robert Wood Johnson Medical School, Rutgers University, Piscataway Township, NJ. Scott J. Fudemberg, MD, is ophthalmologist and glaucoma specialist, Glaucoma Research Center, Wills Eye Hospital, Philadelphia.

The purpose of this study was to evaluate the effects of a six-month social worker intervention for participants with a glaucoma-related diagnosis in an urban ophthalmic setting (N = 40). The social worker assessed common barriers to eye care, helping participants with transportation, access to low-vision resources, and supportive counseling. The Distress Thermometer, Patient Health Questionnaire-9, and a satisfaction survey were administered to determine the effect of the social worker intervention and participants' overall impressions of the social worker. Read More

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http://dx.doi.org/10.1093/hsw/hly038DOI Listing
December 2018

Increased postural stiffness during challenging postural tasks in patients with knee osteoarthritis with high pain sensitization.

Clin Biomech (Bristol, Avon) 2018 Dec 8;61:129-135. Epub 2018 Dec 8.

Center for Neuroplasticity and Pain (CNAP), SMI, Aalborg University, Denmark.

Background: Postural stability is affected in knee osteoarthritis patients who present with pain but the link to pain sensitization is unclear.

Methods: Patients with knee osteoarthritis completed the Knee Injury and Osteoarthritis Outcome Score and pressure pain thresholds were assessed bilaterally at the knee, lower leg and forearm prior to standing quietly (1 min) on a force platform in four conditions: Firm surface with open eyes, firm surface with closed eyes, soft surface with open eyes, and soft surface with closed eyes. Pain intensity during standing was assessed via numerical rating scale. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02680033183042
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http://dx.doi.org/10.1016/j.clinbiomech.2018.12.004DOI Listing
December 2018
3 Reads

Anti-vascular Endothelial Growth Factor Treatment of Retinopathy of Prematurity: Efficacy, Safety, and Anatomical Outcomes.

Korean J Ophthalmol 2018 Dec;32(6):451-458

Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: To investigate the efficacy, safety, and anatomical outcomes associated with intravitreal anti-vascular endothelial growth factor (VEGF) treatment of retinopathy of prematurity (ROP).

Methods: We performed a retrospective review of intravitreal anti-VEGF (bevacizumab or ranibizumab) treatment of 153 eyes (83 infants) diagnosed with ROP at two tertiary hospitals from June 2011 to January 2017. The primary outcome was the rate of recurrence requiring additional treatment; secondary outcomes included incidence of major complications and final refractive error. Read More

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http://dx.doi.org/10.3341/kjo.2018.0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288015PMC
December 2018

Conduct of vaccination in hard-to-reach areas to address potential polio reservoir areas, 2014-2015.

BMC Public Health 2018 Dec 13;18(Suppl 4):1312. Epub 2018 Dec 13.

World Health Organization, Country Representative Office, Abuja, Nigeria.

Background: The Global Vaccine Action Plan (GVAP) seeks to achieve the total realization of its vision through equitable access to immunization as well as utilizing the immunization systems for delivery of other primary healthcare programs. The inequities in accessing hard-to-reach areas have very serious implications for the prevention and control of vaccine-preventable diseases, especially the polio eradication initiative. The Government of Nigeria implemented vaccination in hard-to-reach communities with support from the World Health Organization (WHO) to address the issues of health inequities in the hard-to-reach communities. Read More

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http://dx.doi.org/10.1186/s12889-018-6194-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291919PMC
December 2018
1 Read

Impact of Presbyopia and Its Correction in Low- and Middle-Income Countries.

Asia Pac J Ophthalmol (Phila) 2018 Nov-Dec;7(6):370-374. Epub 2018 Dec 7.

Queen's University Belfast, Centre for Public Health, Belfast, United Kingdom.

Presbyopia affects more than 1 billion people worldwide, and the number is growing rapidly due to the aging global population. Uncorrected presbyopia is the world's leading cause of vision impairment, and as with other causes. The burden falls unfairly on low- and middle-income countries (LMICs), in which rates of presbyopic correction are as low as 10%. Read More

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http://www.apjo.org/Apjo/pdf/id/636.html
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http://dx.doi.org/10.22608/APO.2018449DOI Listing
December 2018
4 Reads

Low-Concentration Atropine for Myopia Progression (LAMP) Study: A Randomized, Double-Blinded, Placebo-Controlled Trial of 0.05%, 0.025%, and 0.01% Atropine Eye Drops in Myopia Control.

Ophthalmology 2019 Jan 6;126(1):113-124. Epub 2018 Jul 6.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.

Purpose: Low-concentration atropine is an emerging therapy for myopia progression, but its efficacy and optimal concentration remain uncertain. Our study aimed to evaluate the efficacy and safety of low-concentration atropine eye drops at 0.05%, 0. Read More

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http://dx.doi.org/10.1016/j.ophtha.2018.05.029DOI Listing
January 2019
6.135 Impact Factor

Adjunctive effect of orthokeratology and low dose atropine on axial elongation in fast-progressing myopic children-A preliminary retrospective study.

Cont Lens Anterior Eye 2018 Nov 24. Epub 2018 Nov 24.

Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai, China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China. Electronic address:

Purpose: To investigate the adjunctive effect of orthokeratology (ortho-k) and low-dose atropine eye drops on axial length elongation in fast-progressing myopic children.

Methods: Axial elongation in 60 eyes of 60 subjects who completed two years of ortho-k treatment was retrospectively reviewed. They were aged between 5. Read More

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http://dx.doi.org/10.1016/j.clae.2018.10.026DOI Listing
November 2018

Metabolic follow-up of a Croatian patient with gyrate atrophy and a new mutation in the gene: a case report.

Biochem Med (Zagreb) 2018 Oct;28(3):030801

Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia.

Gyrate atrophy (GA) of the choroid and retina is a rare autosomal recessive disorder that occurs due to deficiency of the mitochondrial enzyme ornithine aminotransferase (OAT). Hyperornithinemia causes degeneration of the retina with symptoms like myopia, reduced night vision and progressive vision loss. Our patient is a 10-year-old girl with impaired vision and strabismus. Read More

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http://www.biochemia-medica.com/en/journal/28/3/10.11613/BM.
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http://dx.doi.org/10.11613/BM.2018.030801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214690PMC
October 2018
4 Reads

Safety and efficacy of lifitegrast 5% ophthalmic solution in contact lens discomfort.

Clin Ophthalmol 2018 16;12:2079-2085. Epub 2018 Oct 16.

Eye & Vision, Richardson, TX 75082, USA,

Purpose: The aim of this study was to evaluate the safety and efficacy of lifitegrast 5% ophthalmic solution in improving contact lens discomfort (CLD) in patients wearing a low-modulus, nonionic, monthly replacement silicone hydrogel contact lenses (SHCLs).

Patients And Methods: A single center, prospective, open-label study was undertaken on patients wearing monthly replacement, low modulus silicone hydrogel contact lenses. Best-corrected visual acuity (BVA), lissamine staining (LS) and eight item contact lens dry eye questionnaire (CLDEQ-8) scores were assessed at baseline and after 8-week therapy of twice-a-day lifitegrast 5% ophthalmic solution use. Read More

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https://www.dovepress.com/safety-and-efficacy-of-lifitegrast
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http://dx.doi.org/10.2147/OPTH.S184776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200428PMC
October 2018
8 Reads

Pseudophakic mini-monovision: high patient satisfaction, reduced spectacle dependence, and low cost.

BMC Ophthalmol 2018 Nov 9;18(1):293. Epub 2018 Nov 9.

Eye Consultants of Northern Virginia, 8134 Old Keene Mill Rd., Ste. 300, Springfield, VA, 22152, USA.

Background: Cataract surgery with pseudophakic mini-monovision has lower out-of-pocket patient expense than premium multifocal intraocular lenses (IOL). The purpose of this study was to evaluate patient-reported satisfaction and spectacle dependence for key activities of daily living after cataract surgery with pseudophakic mini-monovision. The study also examined statistical relationships between patient demographic variables, visual acuity and satisfaction. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0963-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230294PMC
November 2018
14 Reads
1.075 Impact Factor

Two-year outcomes of a pilot glaucoma suspect telemedicine monitoring program.

Clin Ophthalmol 2018 17;12:2095-2102. Epub 2018 Oct 17.

Department of Ophthalmology, Southern California Permanente Medical Group, Baldwin Park, CA, USA,

Purpose: The purpose of this study was to characterize a pilot program using e-health to monitor glaucoma suspects in a large integrated health system.

Methods: A retrospective chart review of patients enrolled in the first 2 years of a new glaucoma suspect telemedicine monitoring program was conducted. Patients were enrolled in the program after being diagnosed as glaucoma suspects in the regular clinic setting and were eligible for the program if they had better than 20/40 vision, intraocular pressure (IOP) <25 mmHg, a normal baseline visual field, and an optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) without clear evidence of glaucomatous optic nerve damage. Read More

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https://www.dovepress.com/getfile.php?fileID=45492
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https://medicine.umich.edu/dept/ophthalmology/research/facul
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http://www.eyenews.ru/news/
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https://www.dovepress.com/two-year-outcomes-of-a-pilot-glauc
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http://dx.doi.org/10.2147/OPTH.S171263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199971PMC
October 2018
7 Reads

Retrospective analysis of 52 patients with prolactinomas following endoscopic endonasal transsphenoidal surgery.

Medicine (Baltimore) 2018 Nov;97(45):e13198

Department of Neurosurgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi.

Background: Prolactinomas affect patients' quality of life and even endanger lives. The study aimed to investigate the effect of the endoscopic endonasal transsphenoidal approach (EETA) on 52 patients with prolactinomas.

Methods: A total of 52 patients with prolactinomas who had previously undergone EETA in the People's Hospital of Xinjiang Uygur Autonomous Region between January 2013 and December 2017 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000013198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250442PMC
November 2018
5 Reads

Hydroxychloroquine retinopathy - implications of research advances for rheumatology care.

Nat Rev Rheumatol 2018 Dec;14(12):693-703

Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Despite advances in therapy for rheumatic diseases, hydroxychloroquine remains almost universally recommended for the treatment of systemic lupus erythematosus (SLE), and is often used in the management of other rheumatic diseases such as rheumatoid arthritis (RA). However, the major dose-limiting toxicity of hydroxychloroquine is retinopathy that can lead to loss of vision. New highly sensitive screening methods can identify early stages of retinopathy, and studies that include these modalities have indicated a substantially higher prevalence of hydroxychloroquine retinopathy than was previously recognized, resulting in revisions to ophthalmology guidelines and the recommendation of a low dose of hydroxychloroquine for many patients. Read More

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http://dx.doi.org/10.1038/s41584-018-0111-8DOI Listing
December 2018
1 Read

Maximum Reading Speed in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration.

Invest Ophthalmol Vis Sci 2018 03;59(4):AMD195-AMD201

Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

Purpose: Geographic atrophy (GA) is an advanced form of age-related macular degeneration. GA often initially spares the center of the fovea, leading to a functional disconnect between reading speed and distance visual acuity. This study was designed to determine the correlation between baseline GA lesion size, change in lesion size, and maximum reading speed (MRS) over 18 months. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-24238DOI Listing
March 2018
7 Reads

Reactive Oxygen Species-Mediated Damage of Retinal Neurons: Drug Development Targets for Therapies of Chronic Neurodegeneration of the Retina.

Int J Mol Sci 2018 Oct 27;19(11). Epub 2018 Oct 27.

Vision Research Center, Department of Ophthalmology, School of Medicine, University of Missouri-Kansas City, 2411 Holmes St., Kansas City, MO 64108, USA.

The significance of oxidative stress in the development of chronic neurodegenerative diseases of the retina has become increasingly apparent in recent years. Reactive oxygen species (ROS) are free radicals produced at low levels as a result of normal cellular metabolism that are ultimately metabolized and detoxified by endogenous and exogenous mechanisms. In the presence of oxidative cellular stress, ROS are produced in excess, resulting in cellular injury and death and ultimately leading to tissue and organ dysfunction. Read More

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http://www.mdpi.com/1422-0067/19/11/3362
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http://dx.doi.org/10.3390/ijms19113362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274960PMC
October 2018
3 Reads

Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial.

Lancet Gastroenterol Hepatol 2018 Dec 22;3(12):837-844. Epub 2018 Oct 22.

Department of Medicine & Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.

Background: Guidelines recommend the use of neuromodulators in patients with functional dyspepsia not responding to proton pump inhibitors (PPIs) and prokinetics; however, there is a lack of data from randomised controlled trials supporting their use. We aimed to assess the safety and efficacy of imipramine, a tricyclic antidepressant (TCA), in treatment-refractory functional dyspepsia.

Methods: In this single-centre, double-blind, randomised controlled trial, we enrolled consecutive patients with Rome II functional dyspepsia aged 18-80 years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24681253183030
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http://dx.doi.org/10.1016/S2468-1253(18)30303-0DOI Listing
December 2018
16 Reads

What occupational and physical therapists know about farmers' health.

J Agromedicine 2018 Oct 23:1-10. Epub 2018 Oct 23.

c Department of Occupational therapy, MGH Institute of Health Professions , Boston , MA , USA.

Farmers are at high risk for losing their occupation because of their susceptibility for developing chronic conditions and incurring injuries. Although, occupational and physical therapists have basic education in return-to-work methods, specialty training is needed to help farmers with disabilities. The North Carolina AgrAbility Partnership, part of the U. Read More

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http://dx.doi.org/10.1080/1059924X.2018.1538917DOI Listing
October 2018
6 Reads

Conservative treatment cures an elderly pituitary apoplexy patient with oculomotor paralysis and optic nerve compression: a case report and systematic review of the literature.

Clin Interv Aging 2018 12;13:1981-1985. Epub 2018 Oct 12.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,

Background: Whether conservative treatment or surgical management is the most appropriate treatment for pituitary apoplexy (PA) is controversial. In general, if severe symptoms of compression occur, such as oculomotor nerve palsy, neurosurgery is performed to relieve the compression of anatomical structures near the PA.

Case Description: We describe the case of a 79-year-old man who was found to have an intrasellar pituitary incidentaloma. Read More

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https://www.dovepress.com/conservative-treatment-cures-an-el
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http://dx.doi.org/10.2147/CIA.S181109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188166PMC
December 2018
7 Reads

Gene therapy and the adeno-associated virus in the treatment of genetic and acquired ophthalmic diseases in humans: Trials, future directions and safety considerations.

Clin Exp Ophthalmol 2018 Oct 21. Epub 2018 Oct 21.

LVF Ophthalmology Research Centre, Translational Research Institute, Brisbane, Australia.

Voretigene neparvovec-rzyl was recently approved for the treatment of Leber congenital amaurosis, and the use of gene therapy for eye disease is attracting even greater interest. The eye has immune privileged status, is easily accessible, requires a reduced dosage of therapy due to its size and is highly compartmentalized, significantly reducing systemic spread. Adeno-associated virus (AAV), with its low pathogenicity, prolonged expression profile and ability to transduce multiple cell types, has become the leading gene therapy vector. Read More

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http://dx.doi.org/10.1111/ceo.13416DOI Listing
October 2018

Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis.

Cochrane Database Syst Rev 2018 10 16;10:CD007419. Epub 2018 Oct 16.

Department of Translational Surgery and Medicine, Eye Clinic, University of Florence, Largo Brambilla, 3, Florence, Italy, 50134.

Background: Diabetic macular oedema (DMO) is a common complication of diabetic retinopathy. Antiangiogenic therapy with anti-vascular endothelial growth factor (anti-VEGF) can reduce oedema, improve vision and prevent further visual loss. These drugs have replaced laser photocoagulation as the standard of care for people with DMO. Read More

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http://doi.wiley.com/10.1002/14651858.CD007419.pub6
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http://dx.doi.org/10.1002/14651858.CD007419.pub6DOI Listing
October 2018
13 Reads

Monotherapy laser photocoagulation for diabetic macular oedema.

Cochrane Database Syst Rev 2018 10 15;10:CD010859. Epub 2018 Oct 15.

Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Botucatu Medical School, UNESP - Univ Estadual Paulista, Distrito de Rubião Júnior, s/n, Botucatu, São Paulo, Brazil, 18618-970.

Background: Diabetic macular oedema (DMO) is a complication of diabetic retinopathy and one of the most common causes of visual impairment in people with diabetes. Clinically significant macular oedema (CSMO) is the most severe form of DMO. Intravitreal antiangiogenic therapy is now the standard treatment for DMO involving the centre of the macula, but laser photocoagulation is still used in milder or non-central DMO. Read More

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http://doi.wiley.com/10.1002/14651858.CD010859.pub2
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http://dx.doi.org/10.1002/14651858.CD010859.pub2DOI Listing
October 2018
16 Reads

Thyroid hormone signaling specifies cone subtypes in human retinal organoids.

Science 2018 10;362(6411)

Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.

The mechanisms underlying specification of neuronal subtypes within the human nervous system are largely unknown. The blue (S), green (M), and red (L) cones of the retina enable high-acuity daytime and color vision. To determine the mechanism that controls S versus L/M fates, we studied the differentiation of human retinal organoids. Read More

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http://www.sciencemag.org/lookup/doi/10.1126/science.aau6348
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http://dx.doi.org/10.1126/science.aau6348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249681PMC
October 2018
5 Reads

Successful resolution of coats disease by photodynamic therapy: a case report.

BMC Ophthalmol 2018 Oct 11;18(1):264. Epub 2018 Oct 11.

Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama City, Okayama, 700-8558, Japan.

Background: Coats disease is a retinal disease characterized by exudative retinal detachment due to abnormal retinal blood vessels. Coats disease is generally treated using laser photocoagulation and cryotherapy to ablate the abnormal retinal blood vessels. However, if abnormal blood vessels are present near the posterior pole of the eye and there is a severe exudative change there, it is difficult to perform these standard treatments. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0930-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182787PMC
October 2018
9 Reads

Age-related macular degeneration.

Lancet 2018 09;392(10153):1147-1159

Singapore Eye Research Institute, Singapore National Eye Centre, Duke-National University of Singapore, Singapore.

Age-related macular degeneration is a leading cause of visual impairment and severe vision loss. Clinically, it is classified as early-stage (medium-sized drusen and retinal pigmentary changes) to late-stage (neovascular and atrophic). Age-related macular degeneration is a multifactorial disorder, with dysregulation in the complement, lipid, angiogenic, inflammatory, and extracellular matrix pathways implicated in its pathogenesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183155
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http://dx.doi.org/10.1016/S0140-6736(18)31550-2DOI Listing
September 2018
9 Reads
45.220 Impact Factor

Syringomyelia-like syndrome in neuromyelitis optica spectrum disorder complicated with Sjogren's syndrome: a case report.

BMC Neurol 2018 Oct 9;18(1):168. Epub 2018 Oct 9.

Department of Neurology, The Affiliated Hospital of Wei fang Medical University, No 2428 Yuhe Road, Weifang, 261031, Shandong, China.

Background: Besides CSF-flow obstruction, syringomyelia is associated with inflammatory spinal cord lesions. However, syringomyelia-like syndrome concomitant with neuromyelitis optica spectrum disorder (NMOSD) and primary Sjogren's syndrome (pSS) is extremely rare. Here, we would like to report a case of a patient with syringomyelia-like syndrome in NMOSD complicated with Sjogren's Syndrome. Read More

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http://dx.doi.org/10.1186/s12883-018-1170-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178268PMC
October 2018
5 Reads

Interferon-α2a treatment for refractory Behçet's disease.

Taiwan J Ophthalmol 2018 Jul-Sep;8(3):168-172

Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan.

We report a young male patient with Behçet's disease who suffered from sight-threatening recurrences under treatment with azathioprine, cyclosporine, and prednisolone. His uveitis responded well to antitumor necrosis factor (TNF)-alpha (adalimumab) for 5 months subsequently. Severe uveitis recurred soon after discontinuation of anti-TNF alpha therapy and could not be controlled well with reinstitution of the anti-TNF alpha therapy. Read More

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http://dx.doi.org/10.4103/tjo.tjo_99_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169326PMC
October 2018
2 Reads

Benefits of low vision aids to reading accessibility.

Authors:
Keziah Latham

Vision Res 2018 12 17;153:47-52. Epub 2018 Oct 17.

Department of Vision & Hearing Sciences, and Vision & Eye Research Unit, Anglia Ruskin University, Cambridge, UK. Electronic address:

The Reading Accessibility Index (ACC) has been proposed as a single-value reading parameter that can capture information on both reading speed and print sizes that can be read. It is defined as the average reading speed across a relevant range of print sizes (1.3-0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00426989183020
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http://dx.doi.org/10.1016/j.visres.2018.09.009DOI Listing
December 2018
2 Reads

Vidian Nerve Schwannoma: A Rare Skull-Base Neoplasm Presenting with Ocular Manifestations: A Case Report and Literature Review.

Perm J 2018 ;22

Surgeon in the Department of Otolaryngology-Head and Neck Surgery at the Oakland Medical Center in CA

Introduction: Vidian nerve schwannomas are exceedingly rare, with only 7 cases reported since 2006. Patients presenting with ocular symptoms have been reported in only 1 case.

Case Presentation: A 54-year-old woman presented with a 3-month history of right periorbital pressure, third cranial nerve palsy, and visual field defect. Read More

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http://www.thepermanentejournal.org/issues/2018/fall/6868-vi
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http://dx.doi.org/10.7812/TPP/18-021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172031PMC
January 2019
6 Reads

A Systematic Review of Access to Rehabilitation for People with Disabilities in Low- and Middle-Income Countries.

Int J Environ Res Public Health 2018 10 2;15(10). Epub 2018 Oct 2.

International Centre for Evidence in Disability, London School of Hygiene & Tropical Medicine, London WC1 E7HT, UK.

Rehabilitation seeks to optimize functioning of people with impairments and includes a range of specific health services-diagnosis, treatment, surgery, assistive devices, and therapy. Evidence on access to rehabilitation services for people with disabilities in low- and middle-income countries (LMICs) is limited. A systematic review was conducted to examine this in depth. Read More

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http://www.mdpi.com/1660-4601/15/10/2165
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http://dx.doi.org/10.3390/ijerph15102165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210163PMC
October 2018
10 Reads

Melanopsin-Driven Pupil Response and Light Exposure in Non-seasonal Major Depressive Disorder.

Front Neurol 2018 13;9:764. Epub 2018 Sep 13.

Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.

Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGCs) signal non-imaging forming effects of environmental light for circadian phoentrainment, the pupil light reflex, and mood regulation. In seasonal affective disorder, ipRGC dysfunction is thought to cause abberant transmission of the external illumination for photoentrainment. It is not known if patients with non-seasonal depression have abnormal melanospin mediated signaling and/or irregular environmental light exposure. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00764
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http://dx.doi.org/10.3389/fneur.2018.00764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146094PMC
September 2018
9 Reads

Efficacy and safety of ranibizumab monotherapy versus ranibizumab in combination with verteporfin photodynamic therapy in patients with polypoidal choroidal vasculopathy: 12-month outcomes in the Japanese cohort of EVEREST II study.

Clin Ophthalmol 2018 13;12:1789-1799. Epub 2018 Sep 13.

Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.

Purpose: To compare the efficacy and safety of ranibizumab 0.5 mg with or without verteporfin photodynamic therapy in Japanese patients with polypoidal choroidal vasculopathy over 12 months.

Study Design: EVEREST II was a 24-month, Phase IV, multicenter, randomized, double-masked study in Asian patients with symptomatic macular polypoidal choroidal vasculopathy. Read More

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http://dx.doi.org/10.2147/OPTH.S171015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145359PMC
September 2018
7 Reads

Comparative ophthalmic assessment of patients receiving tafenoquine or chloroquine/primaquine in a randomized clinical trial for Plasmodium vivax malaria radical cure.

Int Ophthalmol 2018 Sep 29. Epub 2018 Sep 29.

Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, USA.

Purpose: Ophthalmic safety observations are reported from a clinical trial comparing tafenoquine (TQ) efficacy and safety versus sequential chloroquine (CQ)/primaquine (PQ) for acute Plasmodium vivax malaria.

Methods: In an active-control, double-blind study, 70 adult subjects with microscopically confirmed P. vivax malaria were randomized (2:1) to receive 400 mg TQ × 3 days or 1500 mg CQ × 3 days then 15 mg PQ × 14 days. Read More

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http://dx.doi.org/10.1007/s10792-018-1003-2DOI Listing
September 2018
8 Reads

Clinical profile of childhood blindness and inappropriate enrolment of children in schools for visually impaired in Uttar Pradesh, India.

Indian J Ophthalmol 2018 Oct;66(10):1456-1461

Department of Cornea, Anterior Segment and Refractive Surgery C L Gupta Eye Institute, Ram Ganga Vihar Phase II, Moradabad, Uttar Pradesh, India.

Purpose: To assess major causes of severe visual impairment (SVI)/blindness (BL) in children studying in schools for the blind in western Uttar Pradesh, India and the extent of inappropriate enrolment of children in blind schools.

Methods: Students of five schools for the blind were examined in a tertiary care eye hospital. The anatomical sites and etiology for SVI/BL were recorded using the World Health Organization/Prevention of Blindness standard reporting form. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1251_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173027PMC
October 2018

Retinitis pigmentosa: recent advances and future directions in diagnosis and management.

Authors:
Abigail Fahim

Curr Opin Pediatr 2018 Dec;30(6):725-733

Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.

Purpose Of Review: Retinitis pigmentosa is a group of genetically diverse inherited blinding disorders for which there are no treatments. Owing to recent advances in imaging technology, DNA sequencing, gene therapy, and stem cell biology, clinical trials have multiplied and the landscape is rapidly changing. This review provides a relevant and timely update of current trends and future directions for the diagnosis and management of this disease. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000690DOI Listing
December 2018

Minimally Invasive Interhemispheric Approach for Giant Olfactory Groove Meningioma: Technical Note.

World Neurosurg 2018 Dec 12;120:316-319. Epub 2018 Sep 12.

Neurosurgery Department, Sírio Libanês Hospital, São Paulo, Brazil; State Public Servant Hospital (IAMSPE), São Paulo, Brazil.

Background: Skull base tumors, such as large olfactory groove meningiomas (OGMs), are a challenge for neurosurgeons. However, the tendency to reduce invasive surgeries is gaining more adepts. We describe a minimally invasive interhemispheric approach with a falx window for microsurgical resection of the giant OGM as a technical note. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.006DOI Listing
December 2018
8 Reads

Low-Level Nighttime Light Therapy for Age-Related Macular Degeneration: A Randomized Clinical Trial.

Invest Ophthalmol Vis Sci 2018 Sep;59(11):4531-4541

Division of Optometry and Visual Science, School of Health Sciences, City, University of London, United Kingdom.

Purpose: To investigate the safety, acceptability, and effectiveness of light therapy on the progression of AMD over 12 months.

Methods: This was a phase I/IIa, prospective, proof-of-concept, single-center, unmasked randomized controlled trial. Sixty participants (55 to 88 years) with early AMD in the study eye and neovascular AMD (nAMD) in the fellow eye were recruited from a hospital nAMD clinic. Read More

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http://dx.doi.org/10.1167/iovs.18-24284DOI Listing
September 2018
1 Read