7,327 results match your criteria Low Vision Therapy

Cost-Effectiveness Analysis of No Adjuvant Therapy Versus Partial Breast Irradiation Alone Versus Combined Treatment for Treatment of Low-Risk DCIS: A Microsimulation.

JCO Oncol Pract 2021 May 10:OP2000992. Epub 2021 May 10.

Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.

Purpose: Adjuvant therapy in patients with ductal carcinoma in situ who undergo partial mastectomy remains controversial, particularly for low-risk patients (60 years or older, estrogen-positive, tumor extent < 2.5 cm, grade 1 or 2, and margins ≥ 3 mm). We performed a cost-effectiveness analysis comparing three strategies: no adjuvant treatment after surgery, a five-fraction course of accelerated partial breast irradiation using intensity-modulated radiation therapy (accelerated partial breast irradiation [APBI]-alone), or APBI plus an aromatase inhibitor for 5 years. Read More

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Clinical practice patterns in the management of dry eye disease: A TFOS international survey.

Ocul Surf 2021 May 5. Epub 2021 May 5.

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand.

Purpose: To examine clinical management and prescribing patterns for dry eye disease (DED), in relation to severity and subtype, by eyecare practitioners across the globe.

Methods: An online-anonymous cross-sectional survey (on Qualtrix) translated into 14 languages was distributed to eyecare practitioners across the globe. The survey included six questions around the management of DED, in relation to severity and subtype. Read More

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Retinal changes associated with multivitamin deficiency before and after supplementation.

Acta Neurol Scand 2021 May 7. Epub 2021 May 7.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

Background: Nutritional visual defects are apparently uncommon nowadays in developed nations. Retinal change-related visual defects caused by hypovitaminoses may be underdiagnosed.

Aim Of The Study: To investigate the retinal structural and functional changes in a patient with multivitamin deficiency before and during vitamin supplementation. Read More

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Activity of Deposited Lysozyme on Contemporary Soft Contact Lenses Exposed to Differing Lens Care Systems.

Clin Ophthalmol 2021 23;15:1727-1733. Epub 2021 Apr 23.

Centre for Ocular Research and Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada.

Purpose: The amount of protein deposition on soft contact lenses and to what extent the proteins are denatured may have an impact on comfortable wearing times of contact lenses. The purpose of this study was to evaluate the effects of two lens care systems on total protein and the quantity and activity of lysozyme deposited on worn senofilcon A, silicone hydrogel contact lenses.

Participants And Methods: Thirty symptomatic soft contact lens wearers were enrolled into a 4-week prospective, randomized, bilateral eye, daily-wear, crossover, double-masked study. Read More

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Comparing Botulinum Toxin Injections with Extraocular Muscle Surgery in Toddlers with Esotropia: A Retrospective Analysis.

Klin Monbl Augenheilkd 2021 Apr 30;238(4):478-481. Epub 2021 Apr 30.

Ophthalmology, Universitätsspital Basel Augenklinik, Basel, Switzerland.

Background: In toddlers with esotropia, early alignment of the visual axes either with extraocular muscle surgery (EOMS) or botulinum toxin injections (BTIs) into both medial rectus muscles may result in improved depth perception. We compared the outcome of BTIs with EOMS in toddlers in order to gain further insight into the advantages and disadvantages of either method.

Patients And Methods: In this retrospective study, our encrypted database was searched for toddlers with esotropia aged 35 months or younger at the time of initial treatment with either BTIs or EOMS and who had a follow-up of at least 2 years. Read More

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Age-Related Macular Degeneration.

Med Clin North Am 2021 May 2;105(3):473-491. Epub 2021 Apr 2.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 North Michigan Avenue, Suite 440, Chicago, IL 60611, USA. Electronic address:

Age-related macular degeneration (AMD) is a leading cause of blindness. The main risk factor is advancing age, with the severity of vision loss ranging from mild to severe. There is a 25% risk of early AMD and 8% risk of late AMD in patients over the age of 75, with the number of cases expected to increase because of the aging population. Read More

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Clinical Remission Using Personalized Low-Dose Intravenous Infusions of -acetylcysteine with Minimal Toxicities for Interstitial Cystitis/Bladder Pain Syndrome.

J Pers Med 2021 Apr 24;11(5). Epub 2021 Apr 24.

Department of Medicine, The Maharaj Institute of Immune Regenerative Medicine, Boynton Beach, FL 33437, USA.

Interstitial Cystitis or Bladder Pain Syndrome (IC/BPS) is a heterogeneous condition characterized by elevated levels of inflammatory cytokines, IL-1β, IL-6, IL-8, IL-10, TNF-α, and is associated with debilitating symptoms of pelvic pain and frequent urination. A standard of care for IC/BPS has not been established, and most patients must undergo a series of different treatment options, with potential for severe adverse events. Here, we report a patient with a 26-year history of IC/BPS following treatment with multiple therapies, including low doses of etodolac, amitriptyline and gabapentin, which she was unable to tolerate because of adverse effects, including headaches, blurred vision and cognitive impairment. Read More

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[Visual quality after implantation of a rotational asymmetric refractive intraocular lens in patients with high myopia and cataract].

Zhonghua Yan Ke Za Zhi 2021 May;57(5):358-365

Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To evaluate the visual quality after phacoemulsification and implantation of a rotational asymmetric refractive intraocular lens in patients with high myopia and cataract. A retrospective cohort study. Sixty-two patients (92 eyes) of the First Affiliated Hospital of Zhengzhou University from June 2017 to December 2019 were evaluated after phacoemulsification and implantation of a rotational asymmetric refractive intraocular lens (LS-313 MF30). Read More

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IMI 2021 Yearly Digest.

Invest Ophthalmol Vis Sci 2021 Apr;62(5)

College of Optometry, University of Houston, Houston, Texas, United States.

Purpose: The International Myopia Institute (IMI) Yearly Digest highlights new research considered to be of importance since the publication of the first series of IMI white papers.

Methods: A literature search was conducted for articles on myopia between 2019 and mid-2020 to inform definitions and classifications, experimental models, genetics, interventions, clinical trials, and clinical management. Conference abstracts from key meetings in the same period were also considered. Read More

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Corticosteroids for periorbital and orbital cellulitis.

Cochrane Database Syst Rev 2021 04 28;4:CD013535. Epub 2021 Apr 28.

Pediatric Outcomes Research Team, Division of Pediatric Medicine, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada.

Background: Periorbital and orbital cellulitis are infections of the tissue anterior and posterior to the orbital septum, respectively, and can be difficult to differentiate clinically. Periorbital cellulitis can also progress to become orbital cellulitis. Orbital cellulitis has a relatively high incidence in children and adults, and potentially serious consequences including vision loss, meningitis, and death. Read More

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Lumbo-pelvic proprioception in sitting is impaired in subgroups of low back pain-But the clinical utility of the differences is unclear. A systematic review and meta-analysis.

PLoS One 2021 26;16(4):e0250673. Epub 2021 Apr 26.

Hellenic Orthopaedic Manipulative Therapy Diploma (HOMTD), Athens, Greece.

Background: Altered spinal postures and altered motor control observed among people with non-specific low back pain have been associated with abnormal processing of sensory inputs. Evidence indicates that patients with non-specific low back pain have impaired lumbo-pelvic proprioceptive acuity compared to asymptomatic individuals.

Objective: To systematically review seated lumbo-pelvic proprioception among people with non-specific low back pain. Read More

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Efficacy and Safety of Ultrasound Cycloplasty for Refractory Glaucoma: A 3-Year Study.

J Glaucoma 2021 May;30(5):428-435

Department of Ophthalmology, Grenoble Alpes University Hospital, Grenoble, France.

Precis: Ultrasound cycloplasty (UCP) treatment using high-intensity focused ultrasound is an effective and safe therapy to reduce intraocular pressure (IOP) in patients with refractory glaucoma over a 3-year period.

Purpose: The purpose of this study was to evaluate the 3-year efficacy and safety of UCP in patients with refractory glaucoma.

Patients And Methods: In all, 104 patients with refractory glaucoma recruited from 2 university hospitals underwent UCP. Read More

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endogenous endophthalmitis in a patient with underlying adenocarcinoma of the colon.

BMJ Case Rep 2021 Apr 22;14(4). Epub 2021 Apr 22.

Ophthalmology, Sunshine Coast Hospital and Health Service, Nambour, Queensland, Australia.

An 83-year-old man presented with a red right eye, rapidly deteriorating vision and no history of ocular trauma or surgery. The patient had no vitritis on presentation, which confounded a diagnosis. Vitreous tap and injection of intravitreal antibiotics was performed day 2, however, the eye could not be saved and was surgically removed. Read More

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A miRNA stabilizing polydopamine nano-platform for intraocular delivery of miR-21-5p in glaucoma therapy.

J Mater Chem B 2021 Apr 30;9(15):3335-3345. Epub 2021 Mar 30.

Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.

The elevation of intraocular pressure (IOP) is an important risk factor in the development of primary open angle glaucoma (POAG), which is the main cause of irreversible vision loss. miRNAs are promising new anti-glaucoma therapeutic agents. However, the low stability and cellular transfection of miRNA in vivo hinder its further application. Read More

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Validation of the Spanish version of the Low Vision Quality of Life Questionnaire.

J Optom 2021 Apr 17. Epub 2021 Apr 17.

Ophthalmology Unit, Hospital de la Esperanza, MAR Health Park, Barcelona, Spain; Institut Català de la Retina, Barcelona, Spain; Universitat Internacional de Catalunya, Barcelona, Spain.

Purpose: To validate the Spanish Low Vision Qualify of Life (SLVQOL) questionnaire, a quality of life instrument specifically designed for patients with visual impairment, and evaluate its psychometric properties.

Methods: The study included 170 visually impaired patients and 195 healthy subjects. Participants were administered the SLVQOL, the NEI VFQ-25, and the EQ 5D-5L questionnaires. Read More

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Painless cervical dilation with "hourglass membranes". Conservative management: our experience.

Minerva Obstet Gynecol 2021 Apr 20. Epub 2021 Apr 20.

Department of Anesthesiology and Reanimation, Virgen Macarena Hospital, Seville, Spain.

Background: Cervical competence is currently conceived as a continuous biological process with progressive degrees of insufficiency, this substituting the traditional vision of cervical competence as being present or absent. The most extreme expression of cervical insufficiency is known as "hourglass membranes". Currently no consensus exists regarding the treatment of pregnancies complicated by the protrusion of amniotic membranes; however, the majority of authors agree on recommending bed rest and performing cervical cerclage, known as "emergent cerclage". Read More

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Recommendations for neonatologists and pediatricians working in first level birthing centers on the first communication of genetic disease and malformation syndrome diagnosis: consensus issued by 6 Italian scientific societies and 4 parents' associations.

Ital J Pediatr 2021 Apr 19;47(1):94. Epub 2021 Apr 19.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Palermo, Italy.

Background: Genetic diseases are chronic conditions with relevant impact on the lives of patients and their families. In USA and Europe it is estimated a prevalence of 60 million affected subjects, 75% of whom are in developmental age. A significant number of newborns are admitted in the Neonatal Intensive Care Units (NICU) for reasons different from prematurity, although the prevalence of those with genetic diseases is unknown. Read More

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Low- vs. high-dose radiotherapy in Graves' ophthalmopathy: a retrospective comparison of long-term results.

Strahlenther Onkol 2021 Apr 16. Epub 2021 Apr 16.

Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitaetsstraße 27, 91054, Erlangen, Germany.

Purpose: Radiotherapy represents an effective treatment option in Graves' ophthalmopathy (GO), leading to palliation of clinical symptoms. However, there are only a limited number of trials comparing the effectiveness of low- vs. high-dose radiotherapy. Read More

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[Clinical observation and analysis on the effect of orthokeratology in myopic anisometropic children].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Apr;55(4):471-477

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University/Beijing Institute of Ophthalmology/Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China.

To evaluate the clinical effects of orthokeratology lens on children with myopic anisometropia. Retrospective case series study. The data of 226 myopic anisometropia children, (10. Read More

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Botulinum toxin type A versus anticholinergics for cervical dystonia.

Cochrane Database Syst Rev 2021 04 14;4:CD004312. Epub 2021 Apr 14.

Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.

Background: This is an update of a Cochrane Review first published in 2005. Cervical dystonia is the most common form of focal dystonia and is a highly disabling movement disorder, characterised by involuntary, usually painful, head posturing. Currently, botulinum toxin type A (BtA) is considered the first line therapy for this condition. Read More

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AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa.

Elife 2021 04 13;10. Epub 2021 Apr 13.

Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States.

Retinitis pigmentosa (RP) is an inherited retinal disease affecting >20 million people worldwide. Loss of daylight vision typically occurs due to the dysfunction/loss of cone photoreceptors, the cell type that initiates our color and high-acuity vision. Currently, there is no effective treatment for RP, other than gene therapy for a limited number of specific disease genes. Read More

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Management of thyroid disorders during the COVID-19 outbreak: a position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM).

Arch Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Departamento de Tireoide, Sociedade Brasileira de Endocrinologia e Metabologia, Rio de Janeiro, RJ, Brasil.

This position statement was prepared to guide endocrinologists on the best approach to managing thyroid disorders during the coronavirus disease (COVID-19) pandemic. The most frequent thyroid hormonal findings in patients with COVID-19, particularly in individuals with severe disease, are similar to those present in the non-thyroidal illness syndrome and require no intervention. Subacute thyroiditis has also been reported during COVID-19 infection. Read More

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Quantifying the Effect of Spectacle Frame Dimensions on Wind-Induced Ocular Plane Evaporation Using an in Vitro Model.

Eye Contact Lens 2021 Mar 19. Epub 2021 Mar 19.

Centre for Ocular Research and Education (C.B.H., W.N.), University of Waterloo School of Optometry and Vision Science, Waterloo, ON, Canada; and Centre for Eye and Vision Research (CEVR) (W.N.), Hong Kong.

Purpose: To quantify the effect of spectacle frame dimensions on wind-induced ocular plane evaporation.

Methods: A drop of 0.5 μL water was pipetted onto an eye of a mannequin head. Read More

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Energy spectral density as valid parameter to compare postural control between subjects with nonspecific chronic low back pain vs healthy subjects: A case-control study.

Musculoskelet Sci Pract 2021 Mar 24;53:102370. Epub 2021 Mar 24.

Department of Medical Surgical-Therapy, Medicine Faculty, Extremadura University, Badajoz, Spain.

Background: Nonspecific chronic low back pain (NSCLBP) is one of the most common and frequent health problems. OBJETIVE: to compare postural control (i.e. Read More

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Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome With Severe Thrombocytopenia and Severe ADAMTS13 Activity Deficiency.

Obstet Gynecol 2021 05;137(5):873-876

Division of Obstetrics and Gynecology, University of British Columbia and Surrey Memorial Hospital, Vancouver, British Columbia, Canada.

Background: Differentiating preeclampsia with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome from thrombotic thrombocytopenic purpura (TTP) can present a diagnostic dilemma.

Case: We report the case of a 34-year-old woman, G1P0, with monochorionic diamniotic twins who presented with new-onset blurry vision, hypertension, and a platelet count of 4×109/L. After a multidisciplinary discussion, a diagnosis of atypical HELLP syndrome was made, despite overlapping features concerning for TTP. Read More

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The Rapid Development and Early Success of Covid 19 Vaccines Have Raised Hopes for Accelerating the Cancer Treatment Mechanism.

S Amanpour

Arch Razi Inst 2021 03 1;76(1):1-6. Epub 2021 Mar 1.

Cancer Biology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

The Covid-19 pandemic has brought about rapid change in medical science. The production of new generation vaccines for this disease has surprised even their most optimistic supporters. Not only have these vaccines proven to be effective, but the importance of this disease and pandemic situation also significantly shortened the long-standing process of validating such products. Read More

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Food insecurity (hunger) and fast-food consumption among 180,164 adolescents aged 12-15 years from 68 countries.

Br J Nutr 2021 Apr 5:1-23. Epub 2021 Apr 5.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona08830, Spain.

Food insecurity has been shown to be associated with fast-food consumption. However, to date, studies on this specific topic are scarce. Therefore, the aim of the present study was to investigate the association between food insecurity and fast-food consumption in adolescents aged 12-15 years from 68 countries (7 low-income, 27 lower middle-income, 20 upper middle-income, 14 high-income countries). Read More

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Efficiency of Machine Learning Algorithms for the Determination of Macrovesicular Steatosis in Frozen Sections Stained with Sudan to Evaluate the Quality of the Graft in Liver Transplantation.

Sensors (Basel) 2021 Mar 12;21(6). Epub 2021 Mar 12.

Experimental Pathology Service, Institute for Biomedical Research of Murcia (IMIB), 30120 Murcia, Spain.

Liver transplantation is the only curative treatment option in patients diagnosed with end-stage liver disease. The low availability of organs demands an accurate selection procedure based on histological analysis, in order to evaluate the allograft. This assessment, traditionally carried out by a pathologist, is not exempt from subjectivity. Read More

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