6,345 results match your criteria Low Vision Therapy


Interferon gamma-1b does not increase markers of bone resorption in autosomal dominant osteopetrosis.

J Bone Miner Res 2019 Mar 19. Epub 2019 Mar 19.

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

In autosomal dominant osteopetrosis type 2 (ADO2) CLCN7 mutations cause impaired osteoclast function. Severe consequences include skeletal fragility despite high bone mass, osteomyelitis, osteonecrosis, bone marrow failure, and severe cranial nerve impingement. There is no effective medical treatment for ADO2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbmr.3715DOI Listing

A case report of an extranodal NK/T-cell lymphoma nasal type, occurring primarily in eyes with masquerade syndrome.

Medicine (Baltimore) 2019 Mar;98(11):e14836

Department of Ophthalmology, The Second Xiangya Hospital.

Rationale: Extranodal natural killer T-cell lymphoma nasal type (ENKL) is an extremely rare tumor with a very low survival rate. In recent decades, only a few ENKL cases have been published. Presenting a special ENKL case lead the authors to emphasize the primary features of ENKL in early diagnosis and therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014836DOI Listing

Reliability and validity of self-reported questionnaires to measure pain and disability in adults with neck pain and its associated disorders: part 3-a systematic review from the CADRE Collaboration.

Eur Spine J 2019 Mar 16. Epub 2019 Mar 16.

UOIT-CMCC Centre for Disability Prevention and Rehabilitation, University of Ontario Institute of Technology (UOIT), 2000 Simcoe St. N., Oshawa, ON, L1H 7K4, Canada.

Purpose: To determine the reliability and validity of self-reported questionnaires to measure pain and disability in adults with grades I-IV neck pain and its associated disorders (NAD).

Methods: We updated the systematic review of the 2000-2010 Bone and Joint Decade Task Force on Neck Pain and its Associated Disorders and systematically searched databases from 2005 to 2017. Independent reviewers screened and critically appraised studies using standardized tools. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00586-019-05949-8DOI Listing

Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration.

Neuron 2019 Mar 12. Epub 2019 Mar 12.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Vision Science Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address:

Light responses are initiated in photoreceptors, processed by interneurons, and synaptically transmitted to retinal ganglion cells (RGCs), which send information to the brain. Retinitis pigmentosa (RP) is a blinding disease caused by photoreceptor degeneration, depriving downstream neurons of light-sensitive input. Photoreceptor degeneration also triggers hyperactive firing of RGCs, obscuring light responses initiated by surviving photoreceptors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2019.02.015DOI Listing

Restoration of high-sensitivity and adapting vision with a cone opsin.

Nat Commun 2019 Mar 15;10(1):1221. Epub 2019 Mar 15.

Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.

Inherited and age-related retinal degenerative diseases cause progressive loss of rod and cone photoreceptors, leading to blindness, but spare downstream retinal neurons, which can be targeted for optogenetic therapy. However, optogenetic approaches have been limited by either low light sensitivity or slow kinetics, and lack adaptation to changes in ambient light, and not been shown to restore object vision. We find that the vertebrate medium wavelength cone opsin (MW-opsin) overcomes these limitations and supports vision in dim light. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-09124-xDOI Listing

Severe clinical immunodeficiency in a patient with human immunodeficiency virus infection and relatively high CD4 counts: a case report.

J Med Case Rep 2019 Mar 14;13(1):86. Epub 2019 Mar 14.

Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.

Background: The coexistence of neuromeningeal cryptococcosis and Kaposi's sarcoma is not surprising in a patient with human immunodeficiency virus infection and a low CD4 count, although it is rarely described. However, we describe such an association in a patient with human immunodeficiency virus infection and a relatively high CD4 count.

Case Presentation: A 41-year old Cameroonian woman presented to our hospital with subacute occipital headaches associated with photophobia, blurred vision, phonophobia, projectile vomiting, and tonic seizures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13256-019-1982-2DOI Listing
March 2019
1 Read

Time-course investigation of postural sway variability: Does anxiety exacerbate the sensory reweighting impairment in chronic stroke survivors?

Neuropsychologia 2019 Mar 8;127:185-194. Epub 2019 Mar 8.

Department of Biomedical Engineering, Khalifa University of Science, Abu Dhabi, United Arab Emirates.

Although anxiety is one of the most prevalent psychological disorders in stroke survivors, its effect on sensory reweighting has not yet been fully studied. The aim of this work was to investigate how anticipation of collision avoidance events affects sensory reweighting in chronic stroke survivors with low and high levels of anxiety (LA-stroke and HA-stroke, respectively), as compared with healthy controls (HC), under the condition of perturbed proprioception. Eighteen LA-stroke and 18 HA-stroke survivors, as well as 18 gender- and age-matched HC, participated in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropsychologia.2019.01.023DOI Listing

Cyclodestructive procedures for refractory glaucoma.

Cochrane Database Syst Rev 2019 Mar 10;3:CD012223. Epub 2019 Mar 10.

Stein Eye Institute, UCLA, 100 Stein Plaza, Los Angeles, California, USA, 90095.

Background: Cyclodestructive procedures are often used in patients with refractory glaucoma who have failed to achieve lower intraocular pressure (IOP) from filtration procedures and maximal medical therapy. Destruction of the ciliary body helps to lower IOP by reducing aqueous humor formation. Of the many types of cyclodestructive procedures, laser cyclophotocoagulation (CPC) has become the most common surgical method for reducing aqueous inflow. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/14651858.CD012223.pub2
Publisher Site
http://dx.doi.org/10.1002/14651858.CD012223.pub2DOI Listing
March 2019
1 Read

The LXXV Edward Jackson Memorial Lecture: Lessons Learned from Avastin and OCT: The Great, The Good, The Bad, and The Ugly.

Am J Ophthalmol 2019 Mar 6. Epub 2019 Mar 6.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA. Electronic address:

Purpose: To describe the synergistic benefits and cost-savings from the use of optical coherence tomography (OCT) and vascular endothelial growth factor (VEGF) inhibitors, particularly intravitreal bevacizumab, in the treatment of exudative age-related macular degeneration (AMD) DESIGN: Retrospective literature review and personal perspective.

Methods: Retrospective literature review and personal perspective.

Results: The introduction of the first clinically useful OCT instrument coincided with early phase clinical trials of a drug that would become known as ranibizumab. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajo.2019.02.036DOI Listing

Calcified mucinous adenocarcinoma of the stomach metastatic to the iris: a case report.

J Med Case Rep 2019 Mar 7;13(1):64. Epub 2019 Mar 7.

Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: Gastric cancer has a wide spectrum of clinical features, imaging manifestations, and pathology. Punctate calcifications in gastric cancer are infrequent but are usually found in mucinous adenocarcinoma. However, there have only been a few autopsy case reports describing the correlation between the radiology and pathology findings of calcified mucinous adenocarcinoma of the stomach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13256-019-1977-zDOI Listing
March 2019
3 Reads

Anti-vascular endothelial growth factor for neovascular age-related macular degeneration.

Cochrane Database Syst Rev 2019 Mar 4;3:CD005139. Epub 2019 Mar 4.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Maumenee 740, Baltimore, Maryland, USA, 21287.

Background: Age-related macular degeneration (AMD) is the most common cause of uncorrectable severe vision loss in people aged 55 years and older in the developed world. Choroidal neovascularization (CNV) secondary to AMD accounts for most cases of AMD-related severe vision loss. Intravitreous injection of anti-vascular endothelial growth factor (anti-VEGF) agents aims to block the growth of abnormal blood vessels in the eye to prevent vision loss and, in some instances, to improve vision. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD005139.pub4DOI Listing
March 2019
2 Reads

Previously Diagnosed Leber's Hereditary Optic Neuropathy with Clinical Signs of Idiopathic Intracranial Hypertension Responsive to Acetazolamide Therapy.

J Ophthalmic Vis Res 2019 Jan-Mar;14(1):109-113

Department of Ophthalmology, Red Crescent Hospital, Dubai, UAE.

Purpose: To present a case of suspected Leber's hereditary optic neuropathy (LHON) with MRI and OCT findings compatible with pseudotumor cerebri responsive to acetazolamide therapy.

Case Report: A five-year-old boy referred to our clinic with optic atrophy and low vision was originally diagnosed with LHON. Laboratory tests were negative for LHON, while OCT and MRI were consistent with pseudotumor cerebri. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jovr.jovr_85_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388523PMC
March 2019
1 Read

Single-center retrospective study of the effectiveness and toxicity of the oral iron chelating drugs deferiprone and deferasirox.

PLoS One 2019 27;14(2):e0211942. Epub 2019 Feb 27.

Department of Ophthalmology and Vision Science, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Iron overload, resulting from blood transfusions in patients with chronic anemias, has historically been controlled with regular deferoxamine, but its parenteral requirement encouraged studies of orally-active agents, including deferasirox and deferiprone. Deferasirox, licensed by the US Food and Drug Administration in 2005 based upon the results of randomized controlled trials, is now first-line therapy worldwide. In contrast, early investigator-initiated trials of deferiprone were prematurely terminated after investigators raised safety concerns. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211942PLOS
February 2019
2 Reads

[Intravitreal injection of low-dose gentamicin for the treatment of ERU-affected horses].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2019 Feb 26;47(1):25-34. Epub 2019 Feb 26.

Klinik für Pferde, Veterinärmedizinische Fakultät der Universität Leipzig.

Objective: Aim of the study was the retrospective evaluation regarding vision and recurrence in equine recurrent uveitis (ERU)-affected horses treated by intravitreal low-dose gentamicin injection in Tierklinik Alt Sammit during the years 2006-2013.

Material And Methods: The study included 50 equine patients (61 ERU-affected eyes) of different age and breed with different stages of ERU. The solution for the injection contained 4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0816-7156DOI Listing
February 2019
1 Read

Dosimetric accuracy of dynamic couch rotation during volumetric modulated arc therapy (DCR-VMAT) for primary brain tumours.

Phys Med Biol 2019 Feb 26. Epub 2019 Feb 26.

Joint Department of Physics Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Radiotherapy treatment plans using dynamic couch rotation during volumetric modulated arc therapy (DCR-VMAT) reduce the dose to organs at risk (OARs) compared to coplanar VMAT, while maintaining the dose to the planning target volume (PTV). This paper seeks to validate this finding with measurements. DCR-VMAT treatment plans were produced for five patients with primary brain tumours and delivered using a commercial linear accelerator (linac). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6560/ab0a8eDOI Listing
February 2019

Rehabilitation needs and activity limitations of adults with a visual impairment entering a low vision rehabilitation service in England.

Ophthalmic Physiol Opt 2019 03;39(2):113-126

Department of Vision & Hearing Sciences, Anglia Ruskin University, Cambridge, UK.

Purpose: To evaluate outcome measures of the Participation and Activity Inventory (PAI) in a sample of adults with acquired visual impairment entering vision rehabilitation. Both Priority Scores, indicating level of rehabilitative need, and Person Measures, indicating goal difficulty, were considered.

Methods: Participants were newly registered adults with visual impairment within Leicestershire, United Kingdom. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/opo.12606
Publisher Site
http://dx.doi.org/10.1111/opo.12606DOI Listing
March 2019
3 Reads

Current Treatment and Management of Infantile Hemangiomas.

Surv Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology, University of Washington, WA, USA; Department of Oculoplastic and Reconstructive Surgery, University of Washington, WA, USA. Electronic address:

Infantile hemangiomas (IHs), otherwise known as infantile capillary hemangiomas, strawberry hemangiomas, or strawberry nevi, are non-malignant vascular tumors that commonly affect children. The natural disease course typically involves growth for up to a year followed by regression without treatment over a period of years, with no cosmetic or functional sequelae. Less commonly, however, IHs can become a threat to vision or even life depending on location and size of the lesion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.survophthal.2019.02.005DOI Listing
February 2019
2 Reads

Perception of Aversive Auditory Stimuli Is Different in Sensory Modulation Disorder and Attention Deficit Hyperactivity Disorder.

Am J Occup Ther 2018 Nov/Dec;72(6):7206205020p1-7206205020p8

Yoram Bonneh, PhD, is Visiting Scientist, Department of Optometry and Vision Science, Bar-Ilan University, Tel Aviv, Israel.

This study examined whether sensory modulation disorder-sensory overresponsivity (SMD-SOR) and attention deficit hyperactivity disorder (ADHD) have a significant effect on the perception of aversive auditory stimuli. Participants were 66 young adult women. The diagnosis of SOR was made using the Sensory Responsiveness Questionnaire, and ADHD was diagnosed by a qualified psychiatrist or neurologist using criteria from the Diagnostic and Statistical Manual of Mental Disorders (4th ed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5014/ajot.2018.022327DOI Listing
March 2019
1 Read

PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq.

Cell Rep 2019 Feb;26(7):1951-1964.e8

Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA; Center for Gene Therapy, University of Iowa Carver College of Medicine, Iowa City, IA, USA. Electronic address:

Toolsets available for in-depth analysis of scRNA-seq datasets by biologists with little informatics experience is limited. Here, we describe an informatics tool (PyMINEr) that fully automates cell type identification, cell type-specific pathway analyses, graph theory-based analysis of gene regulation, and detection of autocrine-paracrine signaling networks in silico. We applied PyMINEr to interrogate human pancreatic islet scRNA-seq datasets and discovered several features of co-expression graphs, including concordance of scRNA-seq-graph structure with both protein-protein interactions and 3D genomic architecture, association of high-connectivity and low-expression genes with cell type enrichment, and potential for the graph structure to clarify potential etiologies of enigmatic disease-associated variants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.01.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394844PMC
February 2019
1 Read

Sirolimus (rapamycin) for the targeted treatment of the fibrotic sequelae of Graves' orbitopathy.

Eye (Lond) 2019 Feb 12. Epub 2019 Feb 12.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Background: Rapamycin (alternatively known as sirolimus) is a macrolide immunosuppressant commonly used for organ transplantation. It acts both on lymphocytes through the mechanistic target of rapamycin (mTOR) pathway to reduce their sensitivity to interleukin-2 (IL-2) and, importantly, also has anti-fibrotic properties by acting on myofibroblasts. The latter have been implicated in the pathogenesis of thyroid eye disease (TED). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41433-019-0340-3DOI Listing
February 2019
2 Reads

Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1.

Anticancer Res 2019 Feb;39(2):827-831

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

This report describes the diagnosis and treatment of a 27-year-old patient with neurofibromatosis 1 (NF1) and late progression of a pre-existing optic pathway glioma (OPG) that caused significant reduction in vision. OPG is one of the diagnostic criteria for establishing the diagnosis of NF1. Most common findings of NF1 are café-au-lait spots, axillary and inguinal freckling of the skin, iris hamartoma (Lisch nodules), and tumors of the central nervous system and peripheral nerves. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13181DOI Listing
February 2019
4 Reads

18F-FDG PET/CT for staging and response assessment of primary parotid MALT lymphoma with multiple sites involvement: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14270

Department of Nuclear Medicine, Lanzhou University Second Hospital, Lanzhou University.

Rationale: Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade B cell lymphoma that generally exhibits an indolent clinical course. Currently, the application of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in MALT lymphoma is still controversial. Herein, we reported a case of using F-FDG PET/CT for staging and response assessment of primary parotid MALT lymphoma with multiple sites involvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380729PMC
February 2019
9 Reads

Choosing appropriate pharmacotherapy for drug-resistant HIV.

Expert Opin Pharmacother 2019 Jan 24:1-12. Epub 2019 Jan 24.

a Divisione Malattie Infettive , Aziende Socio Sanitarie Territoriale Fatebenefratelli Sacco , Milano , Italy.

Introduction: Despite the potency of current antiretrovirals, some patients continue to struggle with the management of the treatment of HIV due to drug resistance-associated mutations. The underlying causes of these developments are usually drug adherence and drug availability as well as the economic affordability of those potent drugs in low to middle-income countries as well as in some industrialised countries. Viral replication, despite therapy, varies by region from 5 to 28. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14656566.2019.1570131DOI Listing
January 2019

Adherence and persistence to hyperlipidemia medications in patients with atherosclerotic cardiovascular disease and those with diabetes mellitus based on administrative claims data in Japan.

Atherosclerosis 2019 Mar 29;282:19-28. Epub 2018 Dec 29.

Teikyo Academic Research Center, Teikyo University, Tokyo, Japan. Electronic address:

Background And Aims: Real-world data on treatment patterns in Japanese hyperlipidemia patients with diabetes mellitus (DM) or prior atherosclerotic cardiovascular diseases (ASCVD) are lacking.

Methods: This is a retrospective, longitudinal cohort analysis of administrative claims data (Japan Medical Data Center [JMDC] and Medical Data Vision [MDV] databases) for patients prescribed a new hyperlipidemia medication between 2014 and 2015. Patients were followed for ≥12 months. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00219150183155
Publisher Site
http://dx.doi.org/10.1016/j.atherosclerosis.2018.12.026DOI Listing
March 2019
2 Reads

A simple method for preventing graft detachment during phacoemulsification cataract surgery after Descemet stripping automated endothelial keratoplasty: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e13992

Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Rationale: Graft detachment and endothelial cell damages are 2 major concerns for cataract surgeries in cases after Descemet stripping automated endothelial keratoplasty (DSAEK). We invented a simple but innovative method to anchor the DSAEK graft with sutures during the surgery to avoid possible graft detachment.

Patient Concerns: We present a 59-year-old male who had done DSAEK surgery. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00005792-201901110-0003
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000013992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336656PMC
January 2019
1 Read

Cerebral Venous Sinus Thrombosis in Systemic Lupus Erythematosus.

Acta Med Indones 2018 Oct;50(4):343-345

Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

A 38-year-old woman presented with general weakness and vaginal bleeding. One month prior, she had been diagnosed with Evans syndrome (haemolytic anemia with positive Coombs test and thrombocytopenia) and was given oral steroid as maintenance therapy. Her serology examination was negative for hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Read More

View Article

Download full-text PDF

Source
October 2018
10 Reads

The Role of Nutrients in Reducing the Risk for Noncommunicable Diseases during Aging.

Nutrients 2019 Jan 4;11(1). Epub 2019 Jan 4.

University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.

An increasing aging population worldwide accounts for a growing share of noncommunicable diseases (NCDs) of the overall social and economic burden. Dietary and nutritional approaches are of paramount importance in the management of NCDs. As a result, nutrition programs are increasingly integrated into public health policies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11010085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356205PMC
January 2019
1 Read

Update of the evidence based, interdisciplinary guideline for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

The Society for Paediatric Rheumatology (GKJR), Germany.

Background: Uveitis in juvenile idiopathic arthritis (JIAU) is frequently associated with the development of complications and visual loss. Topical corticosteroids are the first line therapy, and disease modifying anti-rheumatic drugs (DMARDs) are commonly used. However, treatment has not been standardized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semarthrit.2018.11.004DOI Listing
December 2018
3 Reads

A Randomized, Controlled Trial of Cyclosporine A Cationic Emulsion in Pediatric Vernal Keratoconjunctivitis: The VEKTIS Study.

Ophthalmology 2018 Dec 27. Epub 2018 Dec 27.

University Hospital Necker Enfants Malades, APHP, and Rare Eye Disease Center OPHTARA, CNRS Unit FR3636, Paris Descartes University, Paris, France. Electronic address:

Purpose: Vernal keratoconjunctivitis (VKC) is a chronic, allergic, and potentially severe ocular disease affecting children and adolescents that can lead to impaired quality of life (QoL) and loss of vision. This study evaluated the efficacy and safety of an investigational therapy for severe VKC, cyclosporine A (CsA) cationic emulsion (CE), an oil-in-water emulsion with increased bioavailability versus conventional CsA formulations.

Design: The VErnal KeratoconjunctiviTIs Study (VEKTIS) is a phase 3, multicenter, double-masked, vehicle-controlled trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2018.12.027DOI Listing
December 2018
2 Reads

Visual and somatosensory contributions to infant sitting postural control.

Somatosens Mot Res 2018 Sep - Dec;35(3-4):240-246. Epub 2018 Dec 28.

b Division of Biomechanics and Research Development and Department of Biomechanics , University of Nebraska at Omaha , Omaha , NE , USA.

There are a limited number of studies that have investigated sitting posture during infancy and the contribution of the sensory systems. The goal of this study was to examine the effects of altered visual and somatosensory signals on infant sitting postural control. Thirteen infants (mean age ± SD, 259. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08990220.2018.1551203DOI Listing
December 2018
1 Read

The future of integrative health and medicine in Saudi Arabia.

Integr Med Res 2018 Dec 23;7(4):316-321. Epub 2018 Jun 23.

National Center for Complementary and Alternative Medicine, Ministry of Health, Riyadh, Saudi Arabia.

Saudi Arabia is witnessing a healthcare transformation to face the challenges of the increased burden of noncommunicable diseases and to maintain the quality of healthcare services. However, in Saudi Arabia, where low back and neck pain, depressive disorders, migraine, diabetes, and anxiety disorders cause the most disability, a broader way of integrative health approach is needed to foster healthy lives and promote well-being for all ages. In the presence of the advanced modern medicine healthcare system in Saudi Arabia, the traditional medicine healing system is being used by a substantial proportion of Saudis but like a shadow healthcare system. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22134220183016
Publisher Site
http://dx.doi.org/10.1016/j.imr.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303372PMC
December 2018
9 Reads

Outcomes After Comprehensive Vision Rehabilitation Using Vision-related Quality of Life Questionnaires: Impact of Vision Impairment and National Eye Institute Visual Functioning Questionnaire.

Optom Vis Sci 2019 Feb;96(2):87-94

Lighthouse Guild, New York, New York.

Significance: This research is significant because, although vision-related quality of life (VRQoL) is improved after vision rehabilitation (VR), patients with certain characteristics respond less positively on VRQoL measures, and this should inform future care.

Purpose: The purposes of this study were to evaluate how two VRQoL questionnaires compare in measuring change in patient-reported outcomes after VR and to determine if patient characteristics or occupational therapy (OT) predict higher scores after rehabilitation.

Methods: In a prospective clinical cohort study, 109 patients with low vision completed the Impact of Vision Impairment (IVI) and the National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) before and after VR. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00006324-900000000-9817
Publisher Site
http://dx.doi.org/10.1097/OPX.0000000000001327DOI Listing
February 2019
1 Read

Effect of Vision Therapy on Accommodative Lag in Myopic Children: A Randomized Clinical Trial.

Optom Vis Sci 2019 Jan;96(1):17-26

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

Significance: Accommodative dysfunction has been suggested to be related to the development and progression of myopia. Office-based accommodative/vergence therapy (OBAVT) improved accommodative facility in Chinese myopic children, but it is unclear if such improvement has a role in decreasing myopic progression.

Purpose: The purpose of this study was to compare the effects of OBAVT with home reinforcement and office-based placebo therapy (OBPT) as a treatment to improve accommodative functions (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/OPX.0000000000001316DOI Listing
January 2019
16 Reads

Long-term efficacy of fractionated conformal radiotherapy for the management of primary optic nerve sheath meningioma.

Br J Ophthalmol 2018 Dec 20. Epub 2018 Dec 20.

Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Background/aim: Fractionated conformal radiotherapy (FCRT) is now used to treat vision-threatening optic nerve sheath meningioma (ONSM), but long-term efficacy and safety data are lacking; the purpose of this study was to assess these key data.

Methods: This is a retrospective chart review with prospective follow-up of adult patients treated with FCRT for primary ONSM at four academic medical centres between 1995 and 2007 with ≥10 years of follow-up after treatment.

Results: 16 patients were identified with a mean post-treatment follow-up of 14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313135DOI Listing
December 2018
5 Reads

The influence of word frequency on word reading speed when individuals with macular diseases read text.

Vision Res 2019 02 4;155:1-10. Epub 2019 Jan 4.

Aix-Marseille University, Marseille, France; Laboratoire de Psychologie Cognitive, CNRS, Marseille, France.

People with central field loss (CFL) use peripheral vision to identify words. Eccentric vision provides ambiguous visual inputs to the processes leading to lexical access. Our purpose was to explore the hypothesis that this ambiguity leads to strong influences of inferential processes, our prediction being that increasing word frequency would decrease word reading time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.visres.2018.12.002DOI Listing
February 2019
1 Read

Use of bevacizumab as a single agent or in adjunct with traditional chemotherapy regimens in children with unresectable or progressive low-grade glioma.

Cancer Med 2019 Jan 19;8(1):40-50. Epub 2018 Dec 19.

Children's Cancer Centre, The Royal Children's Hospital, Melbourne, Victoria, Australia.

In pediatric low-grade gliomas not amenable to complete resection, various chemotherapy regimens are the mainstream of treatment. An excellent overall survival of these patients makes justification of the intensification of chemotherapy difficult and calls for the development of new strategies. Bevacizumab, a humanized monoclonal antibody directed against Vascular endothelial growth factor (VEGF), has been successfully used in combination with irinotecan in a number of adult and pediatric studies and reports. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cam4.1799
Publisher Site
http://dx.doi.org/10.1002/cam4.1799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346232PMC
January 2019
6 Reads

Chewing Difficulty Should be Included as a Geriatric Syndrome.

Nutrients 2018 Dec 17;10(12). Epub 2018 Dec 17.

Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Recent studies have noted an association between chewing difficulties and frailty. In a pilot survey of primary care needs of older people living in the community using automated methods, we examined the prevalence of chewing difficulties and the cross-sectional association with other geriatric syndromes, chronic diseases, and the use of hospital services. A brief multi-domain geriatric assessment was administered to 2259 men and women using a mobile device, the data uploaded to the cloud and analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu10121997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315631PMC
December 2018

A Randomized Trial to Evaluate the Effect of Toric Versus Spherical Contact Lenses on Vision and Eyestrain.

Eye Contact Lens 2019 Jan;45(1):28-33

The Ocular Surface Institute (D.A.B., D.R.P.), University of Houston College of Optometry, Houston, TX; University of Alabama at Birmingham School of Optometry (S.M.C., J.J.N.), Birmingham, AL; The Ohio State University College of Optometry (K.M.B.), Columbus, OH; Alcon Laboratories (J.H.M.), Fort Worth, TX; Department of Biomedical Engineering (S.H.S.), University of Rochester, Rochester, NY; and Johnson & Johnson Vision Care, Inc (B.K.L., K.O.L.), Jacksonville, FL.

Objectives: To compare the effect of toric versus spherical soft contact lenses on objective measures of visual performance using visual acuity and electromyography of the orbicularis oculi muscle.

Methods: Current soft contact lens wearers with -0.75 to -1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICL.0000000000000528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319569PMC
January 2019

Impact of a Social Worker in a Glaucoma Eye Care Service: A Prospective Study.

Health Soc Work 2019 Feb;44(1):48-56

Lisa A. Hark, PhD, RD, is professor of ophthalmic sciences, administrative director of Jonas Children's Vision Care, and director of the Clinical Trials Unit, Irving Medical Center, Columbia University, 635 West 165th Street, Mailbox 10, New York, NY 10032; e-mail: Malika Madhava, BS; Anjithaa Radakrishnan, BS, are medical students, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia. Catherine Anderson-Quiñones, BM, is study coordinator, Glaucoma Research Center, Wills Eye Hospital, Philadelphia. Debra Robinson, MSS, LSW, is a medical social worker, Generations Life Care, Chadds Ford, PA. Jennifer Adeghate, MD, is resident physician, Department of Ophthalmology, Weill Cornell Medical Center, New York. Stephen Silva, MD, is orthopedic resident (surgery), Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia. Tingting Zhan, PhD, is a biostatistician, Department of Pharmacology and Experimental Therapeutics, Division of Biostatistics, Thomas Jefferson University, Philadelphia. Tomilade Adepoju, MD, is medical doctor and ophthalmology resident, Department of Ophthalmology, Nassau University Medical Center, East Meadow, NY. Yatee Dave, BA, is a medical student, Robert Wood Johnson Medical School, Rutgers University, Piscataway Township, NJ. Scott J. Fudemberg, MD, is ophthalmologist and glaucoma specialist, Glaucoma Research Center, Wills Eye Hospital, Philadelphia.

The purpose of this study was to evaluate the effects of a six-month social worker intervention for participants with a glaucoma-related diagnosis in an urban ophthalmic setting (N = 40). The social worker assessed common barriers to eye care, helping participants with transportation, access to low-vision resources, and supportive counseling. The Distress Thermometer, Patient Health Questionnaire-9, and a satisfaction survey were administered to determine the effect of the social worker intervention and participants' overall impressions of the social worker. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hsw/hly038DOI Listing
February 2019
1 Read

Increased postural stiffness during challenging postural tasks in patients with knee osteoarthritis with high pain sensitization.

Clin Biomech (Bristol, Avon) 2019 Jan 8;61:129-135. Epub 2018 Dec 8.

Center for Neuroplasticity and Pain (CNAP), SMI, Aalborg University, Denmark.

Background: Postural stability is affected in knee osteoarthritis patients who present with pain but the link to pain sensitization is unclear.

Methods: Patients with knee osteoarthritis completed the Knee Injury and Osteoarthritis Outcome Score and pressure pain thresholds were assessed bilaterally at the knee, lower leg and forearm prior to standing quietly (1 min) on a force platform in four conditions: Firm surface with open eyes, firm surface with closed eyes, soft surface with open eyes, and soft surface with closed eyes. Pain intensity during standing was assessed via numerical rating scale. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02680033183042
Publisher Site
http://dx.doi.org/10.1016/j.clinbiomech.2018.12.004DOI Listing
January 2019
7 Reads

Anti-vascular Endothelial Growth Factor Treatment of Retinopathy of Prematurity: Efficacy, Safety, and Anatomical Outcomes.

Korean J Ophthalmol 2018 Dec;32(6):451-458

Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: To investigate the efficacy, safety, and anatomical outcomes associated with intravitreal anti-vascular endothelial growth factor (VEGF) treatment of retinopathy of prematurity (ROP).

Methods: We performed a retrospective review of intravitreal anti-VEGF (bevacizumab or ranibizumab) treatment of 153 eyes (83 infants) diagnosed with ROP at two tertiary hospitals from June 2011 to January 2017. The primary outcome was the rate of recurrence requiring additional treatment; secondary outcomes included incidence of major complications and final refractive error. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3341/kjo.2018.0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288015PMC
December 2018
1 Read

Conduct of vaccination in hard-to-reach areas to address potential polio reservoir areas, 2014-2015.

BMC Public Health 2018 Dec 13;18(Suppl 4):1312. Epub 2018 Dec 13.

World Health Organization, Country Representative Office, Abuja, Nigeria.

Background: The Global Vaccine Action Plan (GVAP) seeks to achieve the total realization of its vision through equitable access to immunization as well as utilizing the immunization systems for delivery of other primary healthcare programs. The inequities in accessing hard-to-reach areas have very serious implications for the prevention and control of vaccine-preventable diseases, especially the polio eradication initiative. The Government of Nigeria implemented vaccination in hard-to-reach communities with support from the World Health Organization (WHO) to address the issues of health inequities in the hard-to-reach communities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12889-018-6194-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291919PMC
December 2018
3 Reads

Impact of Presbyopia and Its Correction in Low- and Middle-Income Countries.

Asia Pac J Ophthalmol (Phila) 2018 Nov-Dec;7(6):370-374. Epub 2018 Dec 7.

Queen's University Belfast, Centre for Public Health, Belfast, United Kingdom.

Presbyopia affects more than 1 billion people worldwide, and the number is growing rapidly due to the aging global population. Uncorrected presbyopia is the world's leading cause of vision impairment, and as with other causes. The burden falls unfairly on low- and middle-income countries (LMICs), in which rates of presbyopic correction are as low as 10%. Read More

View Article

Download full-text PDF

Source
http://www.apjo.org/Apjo/pdf/id/636.html
Publisher Site
http://dx.doi.org/10.22608/APO.2018449DOI Listing
December 2018
10 Reads

Process evaluation of a National Primary Eye Care Programme in Rwanda.

BMC Health Serv Res 2018 Dec 7;18(1):950. Epub 2018 Dec 7.

Africa Vision Research Institute, Durban, South Africa, University of Calabar, Calabar, Nigeria.

Background: Visual impairment is a global public health problem, with an estimated 285 million affected globally, of which 43% are due to refractive error. A lack of specialist eye care in low and middle-income countries indicates a new model of care would support a task-shifting model and address this urgent need. We describe the features and results of the process evaluation of a national primary eye care (PEC) programme in Rwanda. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12913-018-3718-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286556PMC
December 2018
3 Reads

Evaluation of a novel, patient-mounted system for CT-guided needle navigation-an ex vivo study.

Neuroradiology 2019 Jan 1;61(1):55-61. Epub 2018 Dec 1.

Medical Templates AG, Egg, Switzerland.

Purpose: To describe the features of a novel patient-mounted system for CT-guided needle navigation, the Puncture Cube System (PCS), and to evaluate the accuracy and efficiency of the PCS by (a) applying numerical simulations and (b) by conducting punctures using the system in comparison to punctures using the free-hand method (FHM).

Methods: The PCS consists of a self-adhesive cube that is attached to the patient, with multiple through-holes in the upper and lower template plate and dedicated software that, using a computer vision algorithm, recognizes the cube in a planning scan. The target in the image dataset is connected by a line, here "virtual needle," which passes through the cube. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00234-018-2107-0
Publisher Site
http://dx.doi.org/10.1007/s00234-018-2107-0DOI Listing
January 2019
22 Reads

Topical Rho-Associated Kinase Inhibitor, Y27632, Accelerates Corneal Endothelial Regeneration in a Canine Cryoinjury Model.

Cornea 2019 Mar;38(3):352-359

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA.

Purpose: Corneal endothelial cell regeneration varies by species, with nonhuman primates (NHPs) and rabbits displaying low and high proliferative capacities, respectively. Recent studies report that topical application of rho-associated kinase (ROCK) inhibitors accelerates corneal endothelial wound healing in animal models and human patients with endothelial dysfunction. This study determines the regenerative capacity of canine corneal endothelial cells in vivo and their response to a topical ROCK inhibitor, Y27632, after transcorneal freezing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICO.0000000000001823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397656PMC
March 2019
2 Reads

Impact of ureteral access sheath force of insertion on ureteral trauma: In vivo preliminary study with 7 patients.

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):514-520

Sorbonne Université, GRC n°20 LITHIASE RENALE, AP-HP, Hôpital Tenon, Paris-France.

Background: Ureteral access sheaths (UASs) are commonly used in retrograde intra-renal surgery (RIRS). Despite their advantages, there is a risk of ureteral trauma during their placement and subsequent stricture following surgery. The aim of this study was to evaluate the UAS force of insertion (FOI) during placement and its impact on ureteral trauma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5505/tjtes.2018.15263DOI Listing
November 2018
0.379 Impact Factor

Low-Concentration Atropine for Myopia Progression (LAMP) Study: A Randomized, Double-Blinded, Placebo-Controlled Trial of 0.05%, 0.025%, and 0.01% Atropine Eye Drops in Myopia Control.

Ophthalmology 2019 Jan 6;126(1):113-124. Epub 2018 Jul 6.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.

Purpose: Low-concentration atropine is an emerging therapy for myopia progression, but its efficacy and optimal concentration remain uncertain. Our study aimed to evaluate the efficacy and safety of low-concentration atropine eye drops at 0.05%, 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2018.05.029DOI Listing
January 2019
4 Reads
6.135 Impact Factor

Visual impairment and blindness in institutionalized elderly in Germany.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 27;257(2):363-370. Epub 2018 Nov 27.

Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, D-53127, Bonn, Germany.

Purpose: To determine the prevalence of and identify factors associated with visual impairment and blindness in institutionalized elderly in Germany.

Methods: In this prospective multicenter cross-sectional study, ophthalmic health care need and provision were investigated in institutionalized elderly in 32 nursing homes in Germany. All participants underwent a standardized examination including medical and ocular history, refraction, visual acuity testing, tonometry, biomicroscopy, and dilated funduscopy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-018-4196-1DOI Listing
February 2019
3 Reads