1,751 results match your criteria Low Back Pain and Sciatica


Anti-nerve growth factor antibodies for the treatment of low back pain.

Expert Rev Clin Pharmacol 2020 May 21. Epub 2020 May 21.

Johns Hopkins School of Medicine , Department of Anesthesiology and Critical Care, Baltimore, USA.

Introduction: The treatment of chronic low back pain (cLBP) often involves multimodal pharmacologic and non-pharmacologic strategies. There remain shortcomings with these tools with regards to both effect size and side effects.

Areas Covered: In an effort to better address cLBP, anti-nerve growth factor (NGF) monoclonal antibodies (mAbs) are nearing marketing approval. Read More

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http://dx.doi.org/10.1080/17512433.2020.1772052DOI Listing

Outcomes of Discectomy in Young Adults With Large Central Lumbar Disc Herniations Presenting With Predominant Leg Pain.

Global Spine J 2020 Jun 9;10(4):412-418. Epub 2019 Jul 9.

Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra, India.

Study Design: Retrospective cohort study.

Objectives: Discectomy alone or discectomy with fusion have been 2 polarized options in the management of large lumbar disc herniations presenting with leg-dominant pain in young patients. The objective of the study was to evaluate the outcomes of discectomy in young patients with large central lumbar disc herniation (CLDH) presenting with predominant leg pain. Read More

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http://dx.doi.org/10.1177/2192568219856871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222677PMC

Efficacy of a Short-Term Low-Calorie Diet in Overweight and Obese Patients with Chronic Sciatica: A Randomized Controlled Trial.

J Altern Complement Med 2020 May 20. Epub 2020 May 20.

Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran.

Chronic sciatica is a common condition. According to Traditional Persian Medicine and recent studies, calorie reduction is thought to be helpful for this condition. The purpose of this work is to evaluate a short-term low-calorie diet (LCD) for ameliorating chronic sciatica in the context of pain relief and reduced disability for patients. Read More

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http://dx.doi.org/10.1089/acm.2019.0360DOI Listing

Predicting conservative treatment failure in patients with lumbar disc herniation. Single center, case-control study.

Clin Neurol Neurosurg 2020 Jun 27;193:105867. Epub 2020 Apr 27.

Department of Neurosurgery, Maria Skłodowska-Curie Hospital, District of Łódź-North, Zgierz, Poland.

Objectives: The aim of this study was to identify independent predictors of conservative treatment failure in patients presenting due to lumbar disc herniation-associated low back pain and sciatica.

Patients And Methods: This is a single institution, case-control study including 240 patients that were selected for microsurgical or conservative treatment due to lumbar disc herniation in a 2,5-year period. Bivariate and multivariate analyses were performed in order to identify independent predictors among demographic, clinical and radiographic factors. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105867DOI Listing

Minimal Clinically Important Difference in Patient-Reported Outcome Measures with the Transforaminal Endoscopic Decompression for Lateral Recess and Foraminal Stenosis.

Int J Spine Surg 2020 Apr 30;14(2):254-266. Epub 2020 Apr 30.

University of New Mexico School of Medicine Department of Neurosurgery Albuquerque, New Mexico; Desert Institute for Spine Care, Phoenix, Arizona.

Background: Patient-reported outcome measures (PROMs) have become widely used to better measure patients' judgment of treatment benefits from surgical spine care. The concept of determining the minimal clinically important differences (MCIDs) of PROMs is aimed at assessing the benefits of lumbar spine care that are meaningful to the patient. The goal of this study was to validate the utility of MCIDs of the visual analog score (VAS) and Oswestry Disability Index (ODI) in patients with sciatica-type low back and leg pain due to lateral recess and foraminal stenosis who were treated with directly visualized transforaminal outpatient endoscopic decompression. Read More

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http://dx.doi.org/10.14444/7034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188088PMC

Spinal-Pelvic Dissociation in Pregnancy: Surgical Fixation of Culture-Negative Extrapulmonary Tuberculosis.

Case Rep Orthop 2020 10;2020:9769076. Epub 2020 Apr 10.

St. George's Hospital, University of London, UK.

A 33-year-old gravid female from Pakistan presented to the Emergency Department with persistent, intractable low back pain and neuropathic left L5 leg pain, associated with a left foot drop. There was a notable history of weight loss for 1 year. Investigations revealed a large collection in the right posterior paraspinal muscles tracking from a large bony defect in the right half of her sacrum extending into the pelvis. Read More

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http://dx.doi.org/10.1155/2020/9769076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171626PMC

Spinal Emergency Surgery During Pregnancy: Contemporary Strategies and Outcome.

World Neurosurg 2020 Apr 16. Epub 2020 Apr 16.

Department of Neurosurgery, Hannover Medical School, Hannover, Germany.

Background: Low back pain is a common complaint during pregnancy. However, spinal pathologies, which manifest with severe pain, radiculopathy, and acute neurologic deficits because of disk herniation or mass lesions require special attention. Here, we present our interdisciplinary experience in the surgical management of spinal emergencies during pregnancy. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.019DOI Listing

Non-steroidal anti-inflammatory drugs for acute low back pain.

Cochrane Database Syst Rev 2020 04 16;4:CD013581. Epub 2020 Apr 16.

Erasmus Medical Center, Department of General Practice, Rotterdam, Netherlands.

Background: Acute low back pain (LBP) is a common health problem. Non-steroidal anti-inflammatory drugs (NSAIDs) are often used in the treatment of LBP, particularly in people with acute LBP. In 2008, a Cochrane Review was published about the efficacy of NSAIDs for LBP (acute, chronic, and sciatica), identifying a small but significant effect in favour of NSAIDs compared to placebo for short-term pain reduction and global improvement in participants with acute LBP. Read More

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http://dx.doi.org/10.1002/14651858.CD013581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161726PMC

Composite Anatomical Variations between the Sciatic Nerve and the Piriformis Muscle: A Nepalese Cadaveric Study.

Case Rep Neurol Med 2020 31;2020:7165818. Epub 2020 Mar 31.

Department of Anatomy, Gandaki Medical College, Pokhara, Nepal.

Piriformis syndrome is a rare syndrome which is one of the main causes of nondiscogenic sciatica causing severe low back pain due to entrapment of sciatic nerve either by the hypertrophy or by inflammation of the piriformis muscle. We have carried out dissection in 20 Nepalese cadavers. Out of 40 dissected gluteal regions, 37 exhibited typical appearance of sciatic nerve, piriformis muscle, and their relations resembling type-a, whereas 3 gluteal regions showed composite structural variations resembling type-b and type-c based on Beaton and Anson's classification. Read More

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http://dx.doi.org/10.1155/2020/7165818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150691PMC

Physiotherapy management of sciatica.

J Physiother 2020 Apr 11;66(2):83-88. Epub 2020 Apr 11.

Department of Health Sciences, Faculty of Science, Vrije University Amsterdam, the Netherlands; Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences Research Institute, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jphys.2020.03.005DOI Listing

Risk Factors for Neuropathic Pain in Middle-Aged and Elderly People: A Five-Year Longitudinal Cohort in the Yakumo Study.

Pain Med 2020 Apr 10. Epub 2020 Apr 10.

Department of Rehabilitation, Kansai University of Welfare Sciences, Kashiwara, Osaka, Japan.

Objective: To determine the risk factors for new neuropathic pain (NeP) after five years in healthy middle-aged and elderly volunteers.

Design: Prospective longitudinal cohort study (Yakumo study).

Setting: Clinical evaluation in a health checkup. Read More

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http://dx.doi.org/10.1093/pm/pnaa036DOI Listing

Epidural corticosteroid injections for lumbosacral radicular pain.

Cochrane Database Syst Rev 2020 04 9;4:CD013577. Epub 2020 Apr 9.

Universidade Federal de Minas Gerais (UFMG), Department of Physiotherapy, Av. Pres. Antônio Carlos, 6627, Belo Horizonte - MG, Belo Horizonte, Minas Gerais, Minas Gerais(MG), Brazil, CEP 31270-901.

Background: Lumbosacral radicular pain (commonly called sciatica) is a syndrome involving patients who report radiating leg pain. Epidural corticosteroid injections deliver a corticosteroid dose into the epidural space, with the aim of reducing the local inflammatory process and, consequently, relieving the symptoms of lumbosacral radicular pain. This Cochrane Review is an update of a review published in Annals of Internal Medicine in 2012. Read More

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http://dx.doi.org/10.1002/14651858.CD013577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145384PMC

[Serum biomarkers in acute low back pain and sciatica].

Orv Hetil 2020 Mar;161(13):483-490

Általános Orvostudományi Kar, Neurológiai Klinika, Semmelweis Egyetem Budapest, Balassa u. 6., 1083.

Inflammation contributes to the pathogenesis of low back pain and sciatica. Growing evidence suggests that elevated levels of some inflammatory biomarkers are associated with these conditions. Much of the research evaluating the association between pro- and anti-inflammatory cytokines, chemokines, other regulatory molecules, and low back pain and sciatica, focused on patients with chronic low back pain, while fewer studies addressed the issue of detectable biomarkers in the acute phase. Read More

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http://dx.doi.org/10.1556/650.2020.31665DOI Listing

The effectiveness and safety of acupuncture in the treatment of lumbar disc herniation: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Mar;99(12):e18930

The Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine.

Background: Lumbar disc herniation (LDH) is a common disease that seriously affects patients' quality of life. Although several articles have reported that acupuncture can improve the symptoms of LDH, different guidelines do not evaluate the efficacy of acupuncture consistently, new randomized controlled trials have been published in recent years.The purpose of this study is to evaluate the efficacy and safety of acupuncture for LDH. Read More

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http://dx.doi.org/10.1097/MD.0000000000018930DOI Listing

Standalone lordotic endoscopic wedge lumbar interbody fusion (LEW-LIF™) with a threaded cylindrical peek cage: report of two cases.

J Spine Surg 2020 Jan;6(Suppl 1):S275-S284

Fundación Universitaria Sanitas, Bogotá, D.C., Colombia.

We report two cases of a standalone lordotic endoscopic wedge lumbar interbody fusion (LEW-LIF™) with a stress-neutral non-expandable cylindrical threaded polyether ether ketone (PEEK) interbody fusion implant. Patients underwent full-endoscopic transforaminal decompression and fusion for symptomatic lateral recess stenosis due to disc herniation, and hypertrophy of the facet joint complex and ligamentum flavum and no more than grade I spondylolisthesis. Lumbar interbody fusion with cages traditionally calls for posterior supplemental fixation with pedicle screws for added stability. Read More

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http://dx.doi.org/10.21037/jss.2019.06.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063321PMC
January 2020

Lumbar vacuum disc, vertical instability, standalone endoscopic interbody fusion, and other treatments: an opinion based survey among minimally invasive spinal surgeons.

J Spine Surg 2020 Jan;6(Suppl 1):S165-S178

University of New Mexico School of Medicine, Albuquerque, NM, USA.

Background: A diseased lumbar intervertebral vacuum disc void of any structurally intact tissue may be vertically unstable. A primary standalone endoscopic decompression and interbody fusion surgery in the treatment of vertical instability in patients with a vacuum disc may be a more reliable treatment than decompression alone.

Methods: The authors solicited responses to an online survey sent to spine surgeons by email, and chat groups on social media networks, including Facebook, WeChat, WhatsApp, and Linkedin. Read More

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http://dx.doi.org/10.21037/jss.2019.11.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063324PMC
January 2020

Return to work and recovery time analysis after outpatient endoscopic lumbar transforaminal decompression surgery.

J Spine Surg 2020 Jan;6(Suppl 1):S100-S115

Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Background: This study aimed to analyze the return to work (RTW) and recovery time (RT) to narcotic independence following outpatient endoscopic decompression for contained lumbar herniated disc causing sciatica-type low back and leg pain.

Methods: A retrospective study of 442 patients with symptomatic contained lumbar herniated disc was treated with the transforaminal endoscopic decompression surgery. The mean follow-up was 33. Read More

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http://dx.doi.org/10.21037/jss.2019.10.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063315PMC
January 2020

Venous Thromboembolism Manifesting as Sciatica in Two Pregnant Women.

J Obstet Gynaecol Can 2020 Mar 11. Epub 2020 Mar 11.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, NS. Electronic address:

Background: Low back pain is a common presentation among pregnant women.

Case: This case report highlights two women who developed excessive low back radicular nerve symptoms during pregnancy as the initial presentation of proximal venous thromboembolism.

Conclusion: The use of Doppler ultrasound imaging or magnetic resonance imaging is suggested for women presenting with severe clinical symptoms of radicular low back or leg pain in pregnancy to rule out thromboembolism and guide patient management. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.08.031DOI Listing

Lumbar high-intensity zones on MRI: imaging biomarkers for severe, prolonged low back pain and sciatica in a population-based cohort.

Spine J 2020 Mar 3. Epub 2020 Mar 3.

Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA; International Spine Research and Innovation Initiative, RUSH University Medical Center, Chicago, IL, USA. Electronic address:

Background Context: There is often discrepancy between clinical presentation and lumbar magnetic resonance imaging (MRI) findings.

Purpose: The purpose of this study was to assess the relationship of high-intensity zones (HIZs) on MRI with low back pain (LBP), sciatica, and back-related disability.

Study Design: Cross-sectional, population-based Southern Chinese cohort study. Read More

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http://dx.doi.org/10.1016/j.spinee.2020.02.015DOI Listing

Percutaneous Endoscopic Lumbar Discectomy Versus Microdiscectomy for the Treatment of Lumbar Disc Herniation: Pain, Disability, and Complication Rate-A Randomized Clinical Trial.

Int J Spine Surg 2020 Feb 29;14(1):72-78. Epub 2020 Feb 29.

Spine Surgery Division, Instituto de Ortopedia e Traumatologia da Faculdade de Medicina da Universidade de São Paulo, FMUSP, São Paulo, Brazil.

Purpose: The objective was to compare the traditional microdiscectomy with percutaneous endoscopic lumbar discectomy for the treatment of disc herniations regarding pain, disability, and complications.

Methods: Randomized clinical trial with 47 patients with disc herniations treated with 2 different surgical techniques: traditional microdiscectomy or percutaneous endoscopic lumbar discectomy. Forty-seven patients were divided into 2 groups and monitored for 12 months. Read More

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http://dx.doi.org/10.14444/7010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043817PMC
February 2020

Acupuncture for lumbar disc herniation: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Feb;99(9):e19117

Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou, China.

Background: As development of society and change of modern life style, the prevalence of lumbar disc herniation (LDH) has been increasing. Being a major cause of low back pain, sciatica and radicular leg pain, LDH imposes a heavy burden on both individual and society. Because of high surgically intervene rate, non-invasive (non-surgical) treatments are recommended for most cases. Read More

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http://dx.doi.org/10.1097/MD.0000000000019117DOI Listing
February 2020

[Therapeutic management of low back pain in general practice.]

Recenti Prog Med 2020 02;111(2):108-115

LinkHealth Health Economics, Outcomes & Epidemiology, Napoli.

Introduction: Low back pain is one of the most frequent causes of consultation of the General Practitioner (GP). The purpose of the present study is to analyze the therapeutic management of low back pain, in relation to pain intensity, in the primary care setting and to assess its impact on the patient's quality of life.

Methods: From the computerized medical records of 65 GPs, all working in the Salerno province (South of Italy), data concerning non-cancer subjects affected by low back or sciatica pain, over 18 years, who consulted the GP in the period between February 1, 2015 and January 31, 2016, were extracted. Read More

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http://dx.doi.org/10.1701/3309.32801DOI Listing
February 2020

Degenerative findings in lumbar spine MRI: an inter-rater reliability study involving three raters.

Chiropr Man Therap 2020 Feb 11;28(1). Epub 2020 Feb 11.

Department of Sport Sciences and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.

Background: For diagnostic procedures to be clinically useful, they must be reliable. The interpretation of lumbar spine MRI scans is subject to variability and there is a lack of studies where reliability of multiple degenerative pathologies are rated simultaneously. The objective of our study was to determine the inter-rater reliability of three independent raters evaluating degenerative pathologies seen with lumbar spine MRI. Read More

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http://dx.doi.org/10.1186/s12998-020-0297-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011264PMC
February 2020

AAPT Diagnostic Criteria for Chronic Low Back Pain.

J Pain 2020 Feb 6. Epub 2020 Feb 6.

Department of Medicine, Oregon Health & Science University, Portland, OR.

Chronic low back pain conditions are highly prevalent and constitute the leading cause of disability worldwide. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) public-private partnership with the US Food and Drug Administration and the American Pain Society (APS), have combined to create the ACTTION-APS Pain Taxonomy (AAPT). The AAPT initiative convened a working group to develop diagnostic criteria for chronic low back pain. Read More

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http://dx.doi.org/10.1016/j.jpain.2020.01.008DOI Listing
February 2020
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Acupuncture for pediatric low back pain and sciatica: a case report.

Acupunct Med 2020 Feb 5:964528419883274. Epub 2020 Feb 5.

Department of Anesthesia and Critical Care, ARCO, Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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http://dx.doi.org/10.1177/0964528419883274DOI Listing
February 2020

Therapeutic Efficacy and the Impact of the "Dose" Effect of Acupuncture to Treat Sciatica: A Randomized Controlled Pilot Study.

J Pain Res 2019 31;12:3511-3520. Epub 2019 Dec 31.

Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.

Purpose: To investigate the required sample size for and feasibility of a full-scale randomized controlled trial examining the impact of the "dose" effect of acupuncture in treating sciatica.

Patients And Methods: Fifty-seven patients with sciatica, aged 35-70 years, were recruited and screened. Thirty-one participants were randomly assigned to receive "low-dose" manual acupuncture (MAL) (n= 15) or "high-dose" manual acupuncture (MAH) (n=16). Read More

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http://dx.doi.org/10.2147/JPR.S210672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942513PMC
December 2019

[Everyone Has Low Back Pain: Degenerative Lumbar Spinal Disorders and Their Treatment Options].

Praxis (Bern 1994) 2020 Feb;109(2):87-95

Facharzt FMH Neurochirurgie, c/o Neuromed, Zürich.

Everyone Has Low Back Pain: Degenerative Lumbar Spinal Disorders and Their Treatment Options Back pain is one of the most widespread diseases. Up to 84 % of people have low back pain at some point in their lives. Unspecific back pain is treated conservatively. Read More

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http://dx.doi.org/10.1024/1661-8157/a003380DOI Listing
February 2020

A Prospective Long-term Follow-up Study of the Posterior Dynamic Stabilizing System to Treat Back Pain Associated With Degenerative Disc Disease.

Global Spine J 2020 Feb 1;10(1):30-38. Epub 2019 May 1.

Charing Cross Hospital, London, UK.

Study Design: Prospective cohort study.

Objective: To evaluate the long-term effectiveness of a posterior dynamic spine stabilization (PDS) System called PercuDyn system as a treatment for low back pain (LBP) in patients with degenerative disc disease who have failed conservative treatment.

Methods: Thirty-five patients (21 males, 14 females, mean age 36 years) with chronic LBP due to degenerative disc disease underwent percutaneous facet augmentation with the PercuDyn system. Read More

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http://dx.doi.org/10.1177/2192568219844236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963357PMC
February 2020

Pulsed radiofrequency for low-back pain and sciatica.

Expert Rev Med Devices 2020 Feb 23;17(2):83-86. Epub 2020 Jan 23.

Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Roma, Italy.

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http://dx.doi.org/10.1080/17434440.2020.1719828DOI Listing
February 2020

Low Back Pain as a Risk Factor for Recurrent Falls in People with Knee Osteoarthritis.

Arthritis Care Res (Hoboken) 2020 Jan 7. Epub 2020 Jan 7.

Department of System Design Engineering, Faculty of Science and Technology, Keio University, Yokohama, Japan.

Objective: Knee osteoarthritis (OA) has been suggested to increase the risk of falls. Low back pain (LBP) is a potential risk factor for falls in people with knee OA, but this has not been addressed adequately in previous studies. This study aimed to investigate the relationship between LBP and falls in people with knee OA in a 12-month period. Read More

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http://dx.doi.org/10.1002/acr.24136DOI Listing
January 2020

Current therapeutic strategy in osteoarticular brucellosis.

North Clin Istanb 2019 24;6(4):415-420. Epub 2019 Oct 24.

Department of Infectious Diseases, Erciyes University, Faculty of Medicine, Kayseri, Turkey.

Brucellosis is a common zoonotic disease with high morbidity. In the majority of human cases, the causative agent is B. melitensis. Read More

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http://dx.doi.org/10.14744/nci.2019.05658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936947PMC
October 2019

Chronic Back Pain in a Young Female Patient: A Case of Ependymoma Originating from the Conus Medullaris.

Korean J Fam Med 2020 Jan 6;41(1):68-72. Epub 2020 Jan 6.

Department of Radiology, Faculty of Medicine, Universiti Teknologi MARA, Selayang, Malaysia.

We present the case of a 14-year-old Malay girl with an ependymoma of the conus medullaris who presented to multiple general practitioner clinics with a 24-month history of chronic low back pain. The pain was symptomatically managed as a simple musculoskeletal pain and sciatica. Further imaging to aid diagnosis was delayed until the appearance of severe pain with neurological deficits. Read More

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http://dx.doi.org/10.4082/kjfm.18.0157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987024PMC
January 2020

Cross-sectional associations between the diversity of sport activities and the type of low back pain in adulthood.

Eur J Sport Sci 2020 Jan 4:1-11. Epub 2020 Jan 4.

Department of Public Health, University of Helsinki, Helsinki, Finland.

Leisure-time physical activity has a complex relationship with low back pain (LBP). Thus, we aimed to investigate whether the diversity of sport activities is associated with the type of LBP. In the FinnTwin16 study, 4246 (55% females) Finnish twins at mean age 34. Read More

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http://dx.doi.org/10.1080/17461391.2019.1706642DOI Listing
January 2020

Does Patient Blinding Influence Clinical Outcomes After Annular Closure Device Implantation? A Propensity Score-Matched Analysis.

Orthop Res Rev 2019 8;11:177-182. Epub 2019 Nov 8.

Department of Neurosurgery, Haaglanden Medical Center Westeinde, The Hague, The Netherlands.

Background: Awareness of treatment group assignment in a clinical trial may influence patient behavior and bias outcome reporting. The objective of this study was to compare 2-year clinical outcomes in blinded vs unblinded patients who were treated with lumbar discectomy and a bone-anchored annular closure device (ACD) for prevention of lumbar disc reherniation.

Methods: This was a secondary analysis of a randomized trial comparing lumbar discectomy with (n=272) vs without (n=278) implantation of a bone-anchored ACD. Read More

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http://dx.doi.org/10.2147/ORR.S216980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850684PMC
November 2019

Predictive factors for treatment success of transforaminal epidural steroid injection in lumbar disc herniation-induced sciatica

Turk J Med Sci 2020 02 13;50(1):126-131. Epub 2020 Feb 13.

Division of Pain Medicine, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Marmara University, İstanbul, Turkey

Background/aim: The aim of this study was to identify predictive factors for treatment success in transforaminal epidural steroid injection in patients with lumbar disc herniation-induced sciatica.

Materials And Methods: A total of 219 patients who were diagnosed with unilateral sciatica and underwent transforaminal epidural steroid injections at the level of L4-5, L5-S1, or S1 neural foramina between March 2016 and May 2018 were retrospectively analyzed. The presence of transitional vertebrae and the grade of nerve root compression were evaluated by a radiologist. Read More

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http://dx.doi.org/10.3906/sag-1908-167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080350PMC
February 2020

Use of "Inside-Out" Technique for Direct Visualization of a Vacuum Vertically Unstable Intervertebral Disc During Routine Lumbar Endoscopic Transforaminal Decompression-A Correlative Study of Clinical Outcomes and the Prognostic Value of Lumbar Radiographs.

Int J Spine Surg 2019 Oct 31;13(5):399-414. Epub 2019 Oct 31.

Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, New Mexico.

Background: The purpose of this study was to record the frequency of lumbar intervertebral disc vacuum phenomenon on routine lumbar plain films taken prior to transforaminal endoscopic decompression surgery for sciatica-type leg and back pain and to correlate it with visualized intradiscal pathology and clinical outcomes.

Methods: A prospective case series study of 200 consecutive patients with an average mean follow-up of 41.85 months who underwent lumbar endoscopic transforaminal decompression at 236 lumbar levels was conducted. Read More

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http://dx.doi.org/10.14444/6055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833958PMC
October 2019
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Steroids and L-Lysine Aescinate for Acute Radiculopathy Due to a Herniated Lumbar Disk.

Medicina (Kaunas) 2019 Nov 14;55(11). Epub 2019 Nov 14.

SHEI, Uzhhorod National University, Uzhhorod 88000, Ukraine.

Background And Objectives: The efficacy of commonly prescribed analgesic and adjuvant drugs for the management of patients with radiculopathy has not been well established. Oral steroids are commonly used to treat sciatica or radiculopathy due to a herniated disk but the effect remains controversial. L-lysine aescinate showed superiority over placebo or baseline therapy with NSAIDs alone in treating sciatica, but have not been evaluated in an appropriately powered clinical trial. Read More

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http://dx.doi.org/10.3390/medicina55110736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915681PMC
November 2019

Acute rhabdomyolysis following epidural steroid injection: An unusual complication in a patient with low back pain.

Agri 2019 Jul;31(3):150-152

Department of Algology, Ankara University Faculty of Medicine, Ankara, Turkey.

Epidural steroid injection is a very common intervention in the treatment of low back pain and sciatic symptoms. The most common complication for epidural steroid injection is transient headache with or without identifiable dural puncture. Other complications have also been reported, including intravascular entry, local hematoma, bleeding, increased back pain, facial flushing, vasovagal reactions, nausea, and fever. Read More

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http://dx.doi.org/10.5505/agri.2017.54366DOI Listing

"Shooting pain" in lumbar radiculopathy and trigeminal neuralgia, and ideas concerning its neural substrates.

Pain 2020 02;161(2):308-318

Department of Cell and Developmental Biology, Institute of Life Sciences, and the Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel.

Patients with radicular low back pain (radicular LBP, sciatica) frequently describe their pain as "shooting" or "radiating." The dictionary meaning of these words implies rapid movement, and indeed, many sufferers report feeling pain moving rapidly from the lower back or buttock into the leg. But, others do not. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001729DOI Listing
February 2020

Shear Wave Elastographic Investigation of the Immediate Effects of Slump Neurodynamics in People With Sciatica.

J Ultrasound Med 2020 Apr 21;39(4):675-681. Epub 2019 Oct 21.

Centro Interdisciplinar de Estudo da Performance Humana (CIPER), Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal.

Objectives: Neurodynamic techniques are often used to treat people with sciatica pain, but their mechanical effects on the sciatic nerve are unknown. Shear wave elastography (SWE) has been shown to effectively estimate the stiffness of peripheral nerves in real time. The aim of this study was to use SWE to assess the effects of slump neurodynamics in the sciatic stiffness of people with sciatica. Read More

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http://dx.doi.org/10.1002/jum.15144DOI Listing
April 2020
1 Read

Understanding sciatica: illness and treatment beliefs in a lumbar radicular pain population. A qualitative interview study.

BJGP Open 2019 Oct 29;3(3). Epub 2019 Oct 29.

Reader, Division of Population Medicine, Cardiff University, Cardiff, UK.

Background: Several pathological processes contribute to lumbar radicular pain (LRP), commonly known as sciatica. It is not known how patients rationalise the experience of sciatica or understand the diagnosis. Providing clinicians with a better understanding of how patients conceptualise sciatica will help them to tailor information for patients on the management and treatment of the condition. Read More

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http://dx.doi.org/10.3399/bjgpopen19X101654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970588PMC
October 2019
1 Read

Bacteria: back pain, leg pain and Modic sign-a surgical multicentre comparative study.

Eur Spine J 2019 12 1;28(12):2981-2989. Epub 2019 Oct 1.

Karolinska University Hospital, 17164, Stockholm, Sweden.

Purpose: To compare bacterial findings in pain-generating degenerated discs in adults operated on for lumbar disc herniation (LDH), and mostly also suffering from low back pain (LBP), with findings in adolescent patients with non-degenerated non-pain-generating discs operated on for scoliosis, and to evaluate associations with Modic signs on magnetic resonance imaging (MRI). Cutibacterium acnes (Propionibacterium acnes) has been found in painful degenerated discs, why it has been suggested treating patients with LDH/LBP with antibiotics. As multidrug-resistant bacteria are a worldwide concern, new indications for using antibiotics should be based on solid scientific evidence. Read More

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http://dx.doi.org/10.1007/s00586-019-06164-1DOI Listing
December 2019
1 Read

Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies.

Asian Spine J 2019 Dec 4;13(6):875-889. Epub 2019 Oct 4.

Sunshine Medical Academy of Research and Training, Sunshine Hospitals, Secunderabad, India.

Study Design: Development of an in vitro model for assessing the anti-inflammatory efficacies of naringin (Nar) and naringenin (NG).

Purpose: To evaluate the efficacy of natural flavonoids as therapeutic drugs against anti-inflammatory processes in the nucleus pulposus (NP) cells using in-vitro and in-silico methods.

Overview Of Literature: Intervertebral disc (IVD) disease is a common cause of low back pain. Read More

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http://dx.doi.org/10.31616/asj.2019.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894971PMC
December 2019
9 Reads

The ambiguity of sciatica as a clinical diagnosis: A case series.

J Am Assoc Nurse Pract 2019 Sep 24. Epub 2019 Sep 24.

Logan University Health Centers-Integrative Clinics, Chesterfield, Missouri.

Sciatica as a clinical diagnosis is nonspecific. A diagnosis of sciatica is typically used as a synonym for lumbosacral radiculopathy. However, the differential for combined low back and leg pain is broad, and the etiology can be one several different conditions. Read More

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http://dx.doi.org/10.1097/JXX.0000000000000288DOI Listing
September 2019
3 Reads

VA/DoD Clinical Practice Guideline: Diagnosis and Treatment of Low Back Pain.

J Gen Intern Med 2019 11 16;34(11):2620-2629. Epub 2019 Sep 16.

United States Department of Defense, Washington, DC, USA.

Description: In September 2017, the U.S. Department of Veterans Affairs (VA) and U. Read More

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http://dx.doi.org/10.1007/s11606-019-05086-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848394PMC
November 2019
1 Read

Risk Factors for Symptomatic Contralateral Foraminal Stenosis After Unilateral Transforaminal Lumbar Interbody Fusion.

World Neurosurg 2020 Jan 14;133:e452-e458. Epub 2019 Sep 14.

Department of Neurosurgery, Chung-Ang University College of Medicine, Seoul, Korea.

Objective: The most common cause of contralateral symptoms after unilateral transforaminal lumbar interbody fusion (TLIF) is contralateral foraminal stenosis (FS). This retrospective cohort study aimed to investigate the cause of and risk factors for contralateral FS after unilateral TLIF with a single cage.

Methods: Patients with degenerative lumbar spinal disorders who underwent unilateral TLIF at L4-5 were divided into 2 groups: those without contralateral radicular symptoms after surgery (group A; n = 340) and those with contralateral radicular symptoms after surgery (group B; n = 16). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.09.048DOI Listing
January 2020

Is the discopathy associated with Modic changes an infectious process? Results from a prospective monocenter study.

PLoS One 2019 15;14(8):e0221030. Epub 2019 Aug 15.

Rheumatology Departement, University Hospital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France.

Background: The local infectious origin and the putative role of Cutibacterium acnes (CA) of a particular subtype of discopathy (Modic 1) are still debated.

Purpose: To establish the association of CA in intervertebral disc (IVD) and Modic 1 discopathy in patients with low back pain.

Methods: The prevalence of bacteria in IVD samples obtained by anterior approach in patient with chronic low back pain harboring Modic type 1, 2 or no Modic changes was compared to that measured in IVD samples obtained by posterior approach for sciatica. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221030PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695213PMC
March 2020
1 Read

Revision for Endoscopic Diskectomy: Is Lateral Lumbar Interbody Fusion an Option?

World Neurosurg 2020 Jan 6;133:e26-e30. Epub 2019 Aug 6.

Department of Bone Tumor, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. Electronic address:

Objective: This study aims to report the clinical outcome of stand-alone lateral lumbar interbody fusion (LLIF) on recurrent disk herniation and to compare the outcome of stand-alone LLIF to that of conventional transforaminal lumbar interbody fusion (TLIF).

Methods: A retrospective study of 47 patients with recurrent disk herniation was included from January 2008 to October 2016. The inclusion criteria were 1) with recurrent disk herniation that needs revision surgery, 2) with only 1 previous percutaneous endoscopic lumbar diskectomy surgery, 3) underwent 1-level stand-alone LLIF or 1-level TLIF surgery, and 4) with follow-up more than 1 year. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.07.226DOI Listing
January 2020
2.417 Impact Factor