1,826 results match your criteria Low Back Pain and Sciatica


Lumbar Disc Herniation is a Nonnegligible Factor for the Degeneration of Sacroiliac Joints.

Pain Physician 2021 May;24(3):E357-E365

Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, China; The Second School of Clinical Medicine, Southern Medical University, China.

Background: Sacroiliac joint (SIJ) abnormality is a potential source of low back pain (LBP), therefore numerous patients receive various treatments because of the degenerative changes of SIJ. However, the outcome is unfavorable for patients because these morphologic alterations are common but not the origins of LBP. Previous studies revealed lumbar fusion and transitional vertebra increased the prevalence of degeneration of SIJ. Read More

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Repeat Epidural Injections of SP-102 (Dexamethasone Sodium Phosphate Injectable Gel) in Subjects with Lumbosacral Radiculopathy.

J Pain Res 2021 5;14:1231-1239. Epub 2021 May 5.

Global Research and Development, Scilex Pharmaceuticals Inc, Palo Alto, CA, USA.

Purpose: SP-102 is a novel epidural steroid injection (ESI) formulation of 10 mg dexamethasone sodium phosphate in a viscous gel solution. Repeat dosing of ESIs is possible if required for pain relief, but with consideration of hypothalamic-pituitary-adrenal (HPA) axis suppression from prolonged systemic exposure. This phase I/II study investigated the effect of initial and repeat SP-102 injections on HPA suppression and analgesia. Read More

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Epidural steroid compared to placebo injection in sciatica: a systematic review and meta-analysis.

Eur Spine J 2021 May 11. Epub 2021 May 11.

Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.

Purpose: The purpose of this systematic review and meta-analysis was to determine whether epidural steroid injections (ESI) are superior to epidural or non-epidural placebo injections in sciatica patients.

Methods: The PubMed, Embase, Cochrane Library, and Web of science databases were searched for trials comparing ESI to epidural or non-epidural placebo. Risk of bias was assessed using the Cochrane RoB 2 tool. Read More

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Epidemiology of Lumbar Degenerative Phenotypes of Children and Adolescents: A Large-Scale Imaging Study.

Global Spine J 2021 Apr 12:21925682211000707. Epub 2021 Apr 12.

Institute of Integrative Medicine, 107652Shaanxi University of Chinese Medicine, Xi'an, Shaanxi Province, People's Republic of China.

Study Design: Cross-sectional study.

Objective: Recently, there has been a rise in children and adolescents developing low back pain and/or sciatica. Degenerative lumbar spine MRI phenotypes can occur in this population but reports have been sporadic and the true incidence of such spine changes remains debatable. Read More

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Extending the straight leg raise test for improved clinical evaluation of sciatica: reliability of hip internal rotation or ankle dorsiflexion.

BMC Musculoskelet Disord 2021 Mar 24;22(1):303. Epub 2021 Mar 24.

Department of Rehabilitation, Kuopio University Hospital, PL100, 70029 KYS, Kuopio, Finland.

Background: The straight leg raise (SLR) is the most commonly applied physical tests on patients with sciatica, but the sensitivity and specificity ratings for disc hernia and neural compression leave areas for improvement. Hip internal rotation tensions the lumbosacral nerve roots and ankle dorsiflexion tensions the sciatic nerve along its course. We added these movements to the SLR (extended SLR = ESLR) as structural differentiators and tested inter-rater reliability in patients with LBP, with and without sciatica. Read More

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Little needle-scalpel for piriformis syndrome: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Mar;100(12):e25242

Jiangxi University of Traditional Chinese Medicine.

Background: Piriformis syndrome (PS) is a condition in which the sciatic nerve is compressed when passing through the inferior mouth of the piriformis muscle, mainly caused by pain in one hip and leg. In severe cases, patients may experience severe buttock and lower limb pain, discomfort, difficulty walking, and claudication. It is estimated that the annual incidence of low back pain and sciatica is about 40 million cases, and the annual incidence of piriformis syndrome is about 2. Read More

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Vertical traction for lumbar radiculopathy: a systematic review.

Arch Physiother 2021 Mar 15;11(1). Epub 2021 Mar 15.

Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, 40138, Bologna, Italy.

Background: Only low-quality evidence is currently available to support the effectiveness of different traction modalities in the treatment of lumbar radiculopathy (LR). Yet, traction is still very commonly used in clinical practice. Some authors have suggested that the subgroup of patients presenting signs and symptoms of nerve root compression and unresponsive to movements centralizing symptoms may benefit from lumbar traction. Read More

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Cross-cultural validation of the start back screening tool in a Greek low back pain sample.

Musculoskelet Sci Pract 2021 Feb 21;53:102352. Epub 2021 Feb 21.

Department of Physiotherapy, School of Health Sciences, University of Thessaly, Greece.

Background: Keele STarT Back Screening Tool (SBST) is a popular 9-item prognostic recovery questionnaire for low back pain (LBP) with validation studies in several cultural settings, but not Greek.

Objectives: The cross-cultural adaptation and validation of the SBST into Greek among LBP and LBP-associated leg pain patients.

Methods: A five-stage forward-backward translation procedure developed the Greek SBST. Read More

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February 2021

Ultrasound-guided periradicular oxygen-ozone injections as a treatment option for low back pain associated with sciatica.

Int Orthop 2021 May 24;45(5):1239-1246. Epub 2021 Feb 24.

Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090, Italy.

Background: The social impact and economic burden of low back pain are well known among the medical community. A novel therapeutic approach is represented by oxygen-ozone therapy, whose anti-inflammatory effects could be especially useful in patients with herniated discs. The most common administration is through a palpation-guided injection technique, although the use of ultrasound guidance could allow a more precise delivery of the therapeutic substance close to the nerve root. Read More

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Degenerative Lumbar Spinal Stenosis.

Rev Bras Ortop (Sao Paulo) 2021 Feb 23;56(1):9-17. Epub 2020 Jul 23.

Radiologia Musculoesquelética, Hospital Mãe de Deus, Porto Alegre, RS, Brasil.

Degenerative lumbar spinal stenosis is the most frequent cause of low back pain and/or sciatica in the elderly patient. Epidemiology, pathophysiology, clinical manifestations and testing are reviewed in a wide current bibliographic investigation. The importance of the relationship between clinical presentation and imaging study, especially magnetic resonance imaging (MRI), is emphasized. Read More

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February 2021

Markers of Cardiovascular Health in Older Adults with and Without Chronic Low Back and Radicular Leg Pain: A Comparative Analysis.

Pain Med 2021 Feb 15. Epub 2021 Feb 15.

Department of Physical Therapy.

Objectives: There is considerable overlap in risk profiles between chronic low back pain with radiculopathy (CLBPR) and cardiovascular health among older adults; obesity and smoking are related to both conditions and may largely drive the potential relationship. We sought to explore the impact of CLBPR on cardiovascular health outcomes, independent of body mass index (BMI) and current smoking status.

Methods: Age- and sex-matched older adults (60-85 years of age) with (n = 21) and without (n = 21) CLBPR were recruited. Read More

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February 2021

Masquerading Guillain-Barré syndrome: uncommon, in-hospital presentation of Miller-Fisher syndrome shadowed by secondary diseases.

BMJ Case Rep 2021 Feb 4;14(2). Epub 2021 Feb 4.

General Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

Presentation of severe pain syndromes prior to onset of motor weakness is an uncommon but documented finding in patients with Guillain-Barré syndrome (GBS). Sciatica in GBS is a difficult diagnosis when patients present with acute radiculopathy caused by herniated disc or spondylolysis. A middle-aged woman was admitted for severe low back pain, symptomatic hyponatraemia, vomiting and constipation. Read More

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February 2021

Interventionist performs a "sham" lumbar microdiscectomy: Should interventionalists be performing spinal surgery?

Surg Neurol Int 2020 29;11:467. Epub 2020 Dec 29.

Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States.

Background: Neurosurgeons and orthopedists, who have received specific training, should be the ones performing spinal surgery. Here, we present a case in which spinal surgeons secondarily (e.g. Read More

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December 2020

Efficacy and Safety of Medicines Targeting Neurotrophic Factors in the Management of Low Back Pain: Protocol for a Systematic Review and Meta-analysis.

JMIR Res Protoc 2021 Jan 22;10(1):e22905. Epub 2021 Jan 22.

School of Medical Sciences, University of New South Wales, Sydney, Australia.

Background: Low back pain (LBP) is the leading cause of years lived with disability worldwide. Most people with LBP receive the diagnosis of nonspecific LBP or sciatica. Medications are commonly prescribed but have limited analgesic effects and are associated with adverse events. Read More

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January 2021

Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis.

BMJ 2021 01 20;372:m4825. Epub 2021 Jan 20.

Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, 2050, Australia.

Objective: To investigate the efficacy and safety of antidepressants for back and osteoarthritis pain compared with placebo.

Design: Systematic review and meta-analysis.

Data Sources: Medline, Embase, Cochrane Central Register of Controlled Trials, CINAHL, International Pharmaceutical Abstracts, ClinicalTrials. Read More

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January 2021

Computed Tomography-Guided Percutaneous Infiltrations for Piriformis Syndrome: A Single-Center Retrospective Study.

J Long Term Eff Med Implants 2020 ;30(2):113-118

Second Radiology Department, Medical School, National and Kapodistrian University of Athens, University General Hospital "ATTIKON", Athens, Greece.

Piriformis syndrome (PS), first described by Yeoman in 1928, is a general term referring to low back pain, sciatica, and instability. PS has a 6% incidence rate worldwide. In this study, we aim to retrospectively evaluate the effectiveness of computed tomography (CT)-guided percutaneous infiltration in a series of consecutive PS patients who have symptoms that are refractory to conservative therapies. Read More

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January 2020

Clinical features of middle cluneal nerve entrapment neuropathy.

Acta Neurochir (Wien) 2021 03 6;163(3):817-822. Epub 2021 Jan 6.

Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

Background: Entrapment of the middle cluneal nerve (MCN), a peripheral nerve in the buttock, can elicit low back pain (LBP). We examined the epidemiology, clinical course, and treatment of MCN entrapment (MCN-EN).

Methods: Among 383 LBP patients who visited our institute, 105 were admitted for intractable LBP. Read More

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Effectiveness of Mechanical Traction for Lumbar Radiculopathy: A Systematic Review and Meta-Analysis.

Phys Ther 2021 Mar;101(3)

School of Physical Therapy, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Objective: Lumbar radiculopathy (LR) is a pain syndrome caused by compression/irritation of the lumbar nerve root(s). Traction is a well-known and commonly used conservative treatment for LR, although its effectiveness is disputed. The purpose of this systematic review and meta-analysis of randomized controlled trials was to evaluate the effects of different types of traction added to or compared with conservative treatments on pain and disability. Read More

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Pedicular lumbosacral spine fusion for adult/adolescent lumbar developmental high-grade spondylolisthesis.

Surg Neurol Int 2020 4;11:416. Epub 2020 Dec 4.

Department of Neurosurgery, Faculty of Medicine, Benha University, Benha, Al Qalubia, Egypt.

Background: Few series report on the management of high-grade spondylolisthesis (HGS) in adolescents and young adults. This review highlights a series of six consecutive cases with developmental (dysplastic) HGS successfully managed with L3 or L4 to S1 transpedicular screw placement, rather than /noninstrumented lumbosacral fusion.

Methods: The six patients with HGS, according to the Meyerding Grading, presented with low back pain and bilateral sciatica (2016-2020). Read More

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December 2020

Sciatica Presentations and Predictors of Poor Outcomes Following Surgical Decompression of Herniated Lumbar Discs: A Review Article.

Cureus 2020 Nov 21;12(11):e11605. Epub 2020 Nov 21.

Trauma and Orthopaedics, Wythenshawe Hospital, Manchester, GBR.

Pain associated with sciatica is one of the most common indications for surgery. The annual rate of discectomy has increased over recent years, with a significant number of patients reporting a poor outcome or symptom recurrence after surgery. This study aims to evaluate the predictors of poor outcome for patients undergoing lumbar discectomy for sciatica. Read More

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November 2020

The Efficacy of Therapeutic Selective Nerve Block in Treating Lumbar Radiculopathy and Avoiding Surgery.

J Pain Res 2020 18;13:2971-2978. Epub 2020 Nov 18.

Division of Neurosurgery & Spine Unit, Special Surgery Department, University of Jordan, Amman, Jordan.

Background: Selective nerve root block (SNRB) is a procedure that can be used as a diagnostic or a therapeutic method. SNRB can be used in multiple sites, including cervical and lumbar . Our study aims to investigate the clinical effectiveness of the use of fluoroscopically guided therapeutic selective nerve root block as a non-surgical symptom management of lumbar radiculopathy. Read More

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November 2020

Non-discogenic low back pain treated with oxygen-ozone: outcome in selected applications.

J Biol Regul Homeost Agents 2020 Jul-Aug;34(4 Suppl. 1):21-30

Dept of Neuroradiology, Cardarelli Hospital Naples (Napoli), Italy.

Low back pain and sciatica are highly debilitating conditions affecting all socioeconomic groups at an increasingly early age. They are caused by different often concomitant spinal disorders: disc or facet joint disease, spondylolysis (with or without listhesis), vertebral body and interapophyseal arthrosis, spinal stenosis, radicular and synovial cysts and, more rarely, infections and primary or metastatic cancer. Treatment of low back pain and/or sciatica requires an accurate diagnosis based on thorough history-taking and physical examination followed by appropriate imaging tests, namely computed tomography, and/or magnetic resonance scans in addition to standard and morphodynamics X-rays of the spine. Read More

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January 2021

Xp11 translocation renal cell carcinoma with vertebral metastasis presenting with low back pain and sciatica.

Tzu Chi Med J 2020 Oct-Dec;32(4):404-405. Epub 2020 Jun 13.

Department of Radiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

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The Correlation between Histopathology of Herniated Lumbar Intervertebral Disc and Clinical Findings.

Asian J Neurosurg 2020 Jul-Sep;15(3):545-553. Epub 2020 Aug 28.

Department of Pathology, King Fahd University Hospital, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Objective: Prolapsed lumbar disc is one of the most frequent diseases, which is usually presented by motor and sensory deficits. Consistency of herniated disc may play a significant role in surgical treatment and postoperative improvement. The objective of this study is to assess whether the histopathological degeneration in the sample of lumbar discs operated on is correlated to clinical variables and surgical outcomes. Read More

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Are epidural corticosteroid injections effective for lumbosacral radicular pain? A Cochrane Review summary with commentary.

NeuroRehabilitation 2020 ;47(4):509-511

IRCCS Istituto Ortopedico Galeazzi, Italy.

Background: Epidural corticosteroid injection is one of the most common non-surgical procedures for lumbosacral radicular pain.

Objective: To assess efficacy and safety of epidural corticosteroid injections compared with placebo injections in patients with lumbosacral radicular pain.

Methods: A summary and commentary of a Cochrane Review by Oliveira et al. Read More

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The Basal Pharmacology of Palmitoylethanolamide.

Int J Mol Sci 2020 Oct 26;21(21). Epub 2020 Oct 26.

Department of Integrative Medical Biology, Umeå University, SE-901 87 Umeå, Sweden.

Palmitoylethanolamide (PEA, -hexadecanoylethanolamide) is an endogenous compound belonging to the family of -acylethanolamines. PEA has anti-inflammatory and analgesic properties and is very well tolerated in humans. In the present article, the basal pharmacology of PEA is reviewed. Read More

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October 2020

Acute foot drop secondary to lumbar disc prolapse after seizure.

Br J Neurosurg 2020 Oct 27:1-3. Epub 2020 Oct 27.

Atkinson Morley Regional Neurosciences Centre, St George's Hospital, London, UK.

Generalised tonic-clonic seizures have been reported to cause musculoskeletal injuries including vertebral fractures usually without resultant neurological deficit. Lumbar disc prolapse resulting in neurological deficits following seizures has not been reported. We report a 43-year-old man who presented after a generalised seizure at which point he developed worsening of low back pain and left sciatica followed by an acute foot drop. Read More

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October 2020