5,426 results match your criteria Loeffler Endocarditis


Spectrum of pulmonary aspergillosis in Hyper IgE syndrome with autosomal dominant STAT3 deficiency.

J Allergy Clin Immunol Pract 2019 Mar 13. Epub 2019 Mar 13.

Service de Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (APHP), Université Paris Descartes, Paris, France; Institut Pasteur, CNRS, Centre National de Référence Mycoses Invasives et Antifongiques, Unité de Mycologie Moléculaire, UMR 2000, Paris,France. Electronic address:

Background: Autosomal dominant signal transducer and activator of transcription 3 (STAT3) deficiency predisposes to recurrent bacterial pneumonia, complicated by bronchiectasis and cavitations. Aspergillosis is a major cause of morbidity in these patients. However, its diagnosis, classification, and treatment are challenging. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.041DOI Listing

Docosahexaenoic Acid Inhibits Proliferation of EoL-1 Leukemia Cells and Induces Cell Cycle Arrest and Cell Differentiation.

Nutrients 2019 Mar 7;11(3). Epub 2019 Mar 7.

Laboratory of Biochemistry, Department of Biological Applications & Technologies, University of Ioannina, 45110 Ioannina, Greece.

Τhe effect of docosahexaenoic acid (DHA, an omega-3 polyunsaturated fatty acid) upon the proliferation of EoL-1 (Eosinophilic leukemia) cell line was assessed, while additional cellular events during the antiproliferative action were recorded. DHA inhibited EoL-1 cells growth dose-dependently by inducing growth arrest at G0/1 phase of the cell cycle. After DHA addition to the cells, the expression of oncogene was decreased, -mRNA overexpression was observed which was used as a marker of differentiation, and -mRNA increase was recorded. Read More

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http://dx.doi.org/10.3390/nu11030574DOI Listing

Causes of eosinophilic ascites - a systematic review.

Rom J Intern Med 2018 Dec 1. Epub 2018 Dec 1.

Carol Davila School of Medicine, Bucharest, Romania.

Background: In the last years an uprising interest for a relatively unknown entity, eosinophilic ascites (EA), has been recorded. Our aim is to investigate the potential causes of EA development, as well as clinical, laboratory, endoscopic and radiologic features, management and outcome in these patients.

Methods: The following research was performed on PubMed (MEDLINE) database using the medical subject headings [Mesh] terms "Ascites" AND "Eosinophils". Read More

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http://content.sciendo.com/view/journals/rjim/ahead-of-print
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http://dx.doi.org/10.2478/rjim-2018-0041DOI Listing
December 2018
1 Read

Coronary Arteries and the Cell Count.

Circulation 2019 Feb;139(9):1228-1233

Division of Cardiology, University of California, San Francisco (P.D., I.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036124DOI Listing
February 2019

Idiopathic hypereosinophilic syndrome presenting with multiple organ damage: A case report.

Medicine (Baltimore) 2019 Mar;98(10):e14532

Rationale: Idiopathic hypereosinophilic syndrome (IHES) is a rare disease in which patients which present with eosinophilia-associated damage. Previous studies focused on organ damage from increased eosinophilic granulocytosis. We report IHES in a patient who presented with multiple organ damage (MOD). Read More

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http://dx.doi.org/10.1097/MD.0000000000014532DOI Listing
March 2019
2 Reads

Cigarette smoking-induced acute eosinophilic pneumonia: A case report.

Medicine (Baltimore) 2019 Mar;98(9):e14704

Department of Respiratory Medicine, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian.

Rationale: Acute eosinophilic pneumonia (AEP) is a rare pulmonary disease, which is characterized by diffuse pulmonary eosinophilia. The pathogenesis remains unknown. Here we report a patient with AEP following a recently acquired habit of smoking. Read More

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http://dx.doi.org/10.1097/MD.0000000000014704DOI Listing
March 2019
1 Read

A case of Loeffler's endocarditis after initiation of adalimumab.

J Community Hosp Intern Med Perspect 2019 11;9(1):29-32. Epub 2019 Feb 11.

Department of Critical Care/Pulmonary Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.

Tumor necrosis factor antagonists (anti-TNF) are increasingly prescribed as maintenance therapy for a variety of autoimmune conditions. Therefore, frequent monitoring and awareness of side effects are of the utmost importance. Adalimumab is known to cause peripheral eosinophilia, but there are few reports of more severe adverse events. Read More

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http://dx.doi.org/10.1080/20009666.2018.1562852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374942PMC
February 2019
1 Read

Recurrent myocardial infarction in a 50-year-old woman.

Heart 2019 Feb 14. Epub 2019 Feb 14.

University Hospital Hairmyres, East Kilbridge, UK.

CLINICAL INTRODUCTION: A 50-year-old woman presented with an inferoposterior ST-elevation myocardial infarction (STEMI) and underwent emergency percutaneous coronary intervention (PCI). Angiography revealed acute occlusion of the circumflex and right coronary (RCA) arteries. PCI was uncomplicated. Read More

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2018-314114
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http://dx.doi.org/10.1136/heartjnl-2018-314114DOI Listing
February 2019
3 Reads

An Unusual Case of Tricuspid Stenosis.

Eur J Case Rep Intern Med 2018 24;5(4):000836. Epub 2018 Apr 24.

Internal Medicine Department, Centro Hospitalar de São João, Porto, Portugal.

Tricuspid stenosis is an uncommon valvular abnormality commonly associated with other valvular lesions. Ebstein's anomaly is a rare congenital heart malformation characterized primarily by abnormalities of the tricuspid valve and right ventricle. Endomyocardial fibrosis is a restrictive cardiomyopathy observed in tropical and subtropical regions. Read More

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http://dx.doi.org/10.12890/2018_000836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346752PMC
April 2018
1 Read

Tricuspid valve relocation with endomyocardial fibrosis removal for Löeffler's endocarditis.

Eur J Cardiothorac Surg 2019 Feb 8. Epub 2019 Feb 8.

Division of Cardiovascular Surgery, Department of Surgery, Shiga University of Medical Science, Otsu, Japan.

Löffler endocarditis with hypereosinophilic syndrome is rare but can cause critical ventricular obliteration by endomyocardial fibrosis. A 52-year-old woman experienced severe right heart failure with extreme shrinkage of her right ventricle, severe tricuspid regurgitation and marked right atrial enlargement. Preoperative tests showed identical pressures in the right atrium and pulmonary artery. Read More

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http://dx.doi.org/10.1093/ejcts/ezy487DOI Listing
February 2019
2 Reads

Abnormal T-cell phenotype in episodic angioedema with hypereosinophilia (Gleich's syndrome): frequency, clinical implication and prognosis.

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Service de Médecine Interne, Université Versailles Saint-Quentin-en-Yvelines, Centre de Référence des Syndromes Hyperéosinophiliques (CEREO), Hôpital Foch, Suresnes, France.

Background: Episodic Angioedema with eosinophilia (EAE, Gleich's syndrome) is a rare disorder consisting of recurrent episodes of angioedema, hypereosinophilia and frequent elevated serum Immunoglobin M.

Methods: We conducted a retrospective multicenter nationwide study regarding the clinical spectrum and therapeutic management of patients with EAE in France.

Results: Thirty patients were included with a median age at diagnosis of 41 years [5-84]. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.001DOI Listing
February 2019
5 Reads

Saliva-coated titanium biosensor detects specific bacterial adhesion and bactericide caused mass loading upon cell death.

Biosens Bioelectron 2019 Mar 22;129:198-207. Epub 2019 Jan 22.

University Hospital Tübingen, Section Medical Materials Science & Technology, Osianderstr. 2-8, D-72076 Tübingen, Germany. Electronic address:

Bacteria adhering to implanted medical devices can cause invasive microbial infections, of e.g. skin, lung or blood. Read More

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http://dx.doi.org/10.1016/j.bios.2019.01.035DOI Listing
March 2019
1 Read

Mutation in Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure.

Pediatrics 2019 Feb;143(2)

Departments of Pediatrics, Gastroenterology, and Hepatology and

Pediatric intractable autoimmune hepatitis is rare and may be responsible for acute liver failure. Mutations in the itchy E3 ubiquitin protein ligase () gene (located on chromosome 20q11.22) can lead to a deficiency of the encoded protein, resulting in increased T-cell activity with lack of immune tolerance and manifestation of a complex systemic autoimmune disease. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-1554DOI Listing
February 2019
13 Reads

Loeffler Endocarditis: A Diagnosis Made with Cardiovascular Magnetic Resonance.

J Cardiovasc Imaging 2019 Jan;27(1):70-72

Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.4250/jcvi.2019.27.e5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358423PMC
January 2019
1 Read

Siglec-7 on peripheral blood eosinophils: Surface expression and function.

Allergy 2019 Jan 28. Epub 2019 Jan 28.

Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Background: Siglec-7 is an inhibitory receptor (IR) expressed on human blood eosinophils. Whereas activation of other IRs, including Siglec-8 and CD300a, has been shown to downregulate eosinophil function, little is known about the role of Siglec-7 on human eosinophils.

Objective: To examine Siglec-7 expression and function in eosinophils from normal (ND) and eosinophilic (EO) donors. Read More

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http://doi.wiley.com/10.1111/all.13730
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http://dx.doi.org/10.1111/all.13730DOI Listing
January 2019
1 Read

Hypereosinophilic syndrome presenting with bilateral ear fullness.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Jan 22. Epub 2019 Jan 22.

Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Dongguk University, Ilsan Hospital, Siksa-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-773, Republic of Korea. Electronic address:

Introduction: Hypereosinophilic syndrome is a rare disease with hypereosinophilia resulting in end-organ dysfunction. Patients present with organ-associated symptoms, and the targets frequently affected are heart, lung, skin, or the nervous system, and the middle ear involvement is rare.

Case Report: A 30-year-old female with left ear fullness and hearing loss, which persisted for 6months, was finally diagnosed with hypereosinophilic syndrome (HES). Read More

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http://dx.doi.org/10.1016/j.anorl.2018.03.009DOI Listing
January 2019
1 Read

Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement.

BMC Infect Dis 2019 Jan 17;19(1):65. Epub 2019 Jan 17.

Division of Rheumatology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Hon-komagome, Tokyo, 1138677, Bunkyo-ku, Japan.

Background: Herpes simplex virus (HSV) has various presentations, depending on the patient's immune status, age, and the route of transmission. In adults, HSV type 1 is found predominantly in the oral area, and HSV type 2 (HSV-2) is commonly found in the genital area. HSV-2 infection without genital lesions is uncommon. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3721-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337778PMC
January 2019
7 Reads

Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma.

Clin Exp Rheumatol 2019 Jan 14. Epub 2019 Jan 14.

Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

Objectives: The pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) remains poorly understood, and may overlap with eosinophilic asthma and primary hypereosinophilic syndrome (HES). The aim of this study was to analyse a panel of serum cytokines and chemokines as markers of disease activity in patients with these conditions.

Methods: The levels of 54 cytokines and chemokines were measured in the sera of 40 patients with active EGPA, 10 of these patients during inactive disease, 6 patients with HES, 8 with asthma, and 10 healthy controls. Read More

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January 2019
4 Reads

[Differential diagnosis of hypereosinophilia].

Z Rheumatol 2019 Jan 11. Epub 2019 Jan 11.

Vaskulitiszentrum-Süd, Klinik für Innere Medizin, Rheumatologie und Immunologie, Medius Kliniken, Akademisches Lehrkrankenhaus, Universität Tübingen, Kirchheim u. Teck, Deutschland.

Eosinophilia is defined as an elevated absolute number of eosinophilic leukocytes in peripheral blood or tissue. Its absolute number also defines the grade of eosinophilia. The main causes are allergic (including drug side effects) and infectious triggers but malignant and autoimmune diseases can also result in eosinophilia. Read More

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http://dx.doi.org/10.1007/s00393-018-0587-2DOI Listing
January 2019
2 Reads

[Chronic myeloid leukemia presenting with marked eosinophilia].

Rinsho Ketsueki 2018 ;59(12):2594-2599

Department of Hematology, Tonan Hospital.

An 80-year-old female with fever, edema in the lower extremities, and marked eosinophilia was referred to our hospital. Based on the presence of the Philadelphia chromosome, she was diagnosed with chronic myeloid leukemia (CML). Although imatinib induced a complete cytogenetic response (CCyR), CML relapsed after 28 months of starting it. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/12/59_2594/
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http://dx.doi.org/10.11406/rinketsu.59.2594DOI Listing
January 2018
4 Reads

Chronic eosinophilic pneumonia after trastuzumab and radiation therapy for breast cancer: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e14017

Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Rationale: Chronic eosinophilic pneumonia (CEP) is rare and an idiopathic disorder. The disease has been associated with drugs, infection, or irradiation, and its relationship with asthma remains unclear.

Patient Concerns: We reported a case of a 49-year-old female patient after trastuzumab and radiation therapy for breast cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344156PMC
January 2019
8 Reads

Mepolizumab as the first targeted treatment for eosinophilic granulomatosis with polyangiitis: a review of current evidence and potential place in therapy.

Ther Clin Risk Manag 2018 7;14:2385-2396. Epub 2018 Dec 7.

School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy,

Mepolizumab is an anti-interleukin-5 (IL-5) humanized monoclonal antibody that binds to free IL-5. It induces bone marrow eosinophil maturation arrest and decreases eosinophil progenitors and subsequent maturation in the blood and bronchial mucosa. Its use has been extensively studied in severe eosinophilic asthma at a dose of 100 mg subcutaneously (SC) every 4 weeks and, more recently, in other hypereosinophilic syndromes. Read More

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https://www.dovepress.com/mepolizumab-as-the-first-targeted-
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http://dx.doi.org/10.2147/TCRM.S159949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292233PMC
December 2018
10 Reads

Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia.

Leukemia 2019 Feb 20;33(2):415-425. Epub 2018 Dec 20.

Faculty of Medicine, University of Southampton, Southampton, UK.

Determining the underlying cause of persistent eosinophilia is important for effective clinical management but remains a diagnostic challenge in many cases. We identified STAT5B N642H, an established oncogenic mutation, in 27/1715 (1.6%) cases referred for investigation of eosinophilia. Read More

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http://www.nature.com/articles/s41375-018-0342-3
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http://dx.doi.org/10.1038/s41375-018-0342-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365490PMC
February 2019
8 Reads

Advances in diagnosis of mastocytosis and hypereosinophilic syndrome.

Semin Hematol 2019 Jan 28;56(1):22-29. Epub 2018 May 28.

Hematology Section, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1508.

Mastocytosis and hypereosinophilic syndrome is very rare neoplastic hematopoietic diseases. Mastocytosis is characterized by expansion and accumulation of clonal tissue mast cells in skin and/or various internal organs, while hypereosinophilic syndrome manifests with an increased number of eosinophils in the peripheral blood and tissue damage. These diseases represent a diagnostic challenge, since they can have overlapping clinical and pathologic features. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00371963183003
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http://dx.doi.org/10.1053/j.seminhematol.2018.05.005DOI Listing
January 2019
6 Reads

Hypereosinophilia: a diagnostic challenge.

Neth J Med 2018 Dec;76(10):431-436

Harbour Hospital and Institute for Tropical Diseases, Rotterdam, the Netherlands (currently working at Albert Schweitzer Hospital, Rotterdam).

Hypereosinophilia encompasses a broad differential diagnosis of atopy/allergic reactions, drug reactions, parasitic infections and paraneoplastic syndromes. Although mostly of limited clinical significance, hypereosinophilia can also be related to hematological malignancies. One has to be aware of the potential for secondary organ damage for example, in the case of hypereosinophilic syndrome. Read More

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December 2018
2 Reads

Idiopathic hypereosinophilic syndrome with cutaneous involvement: a comparative review of 32 cases.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.

Although idiopathic hypereosinophilic syndrome (HES) is uncommon, we studied the clinical characteristics of this disorder in patients with cutaneous involvement. We chronicle the case of a patient with diffuse skin rash due to idiopathic HES from our clinical experience. Furthermore, a systematic literature search of the medical databases PubMed and Google Scholar was conducted. Read More

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http://dx.doi.org/10.1136/bcr-2018-227137DOI Listing
December 2018
1 Read

The epidemiology and clinical characteristics of myeloproliferative neoplasms in Malaysia.

Exp Hematol Oncol 2018 17;7:31. Epub 2018 Dec 17.

Department of Haematology, Sunway Medical Centre, Kuala Lumpur, Malaysia.

Background: The evolution of molecular studies in myeloproliferative neoplasms (MPN) has enlightened us the understanding of this complex disease consisting of polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). The epidemiology is well described in the western world but not in Asian countries like Malaysia.

Materials And Methods: This retrospective national registry of MPN was conducted from year 2009 to 2015 in Malaysia. Read More

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https://ehoonline.biomedcentral.com/articles/10.1186/s40164-
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http://dx.doi.org/10.1186/s40164-018-0124-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296047PMC
December 2018
24 Reads

Eosinophilia and Kidney Disease: More than Just an Incidental Finding?

J Clin Med 2018 Dec 8;7(12). Epub 2018 Dec 8.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, 6020 Innsbruck, Austria.

Peripheral blood eosinophilia (PBE), defined as 500 eosinophils or above per microliter (µL) blood, is a condition that is not uncommon but often neglected in the management of patients with chronic kidney disease (CKD), acute kidney injury (AKI), or patients on renal replacement therapy (RRT). The nature of PBE in the context of kidney diseases is predominantly secondary or reactive and has to be distinguished from primary eosinophilic disorders. Nonetheless, the finding of persistent PBE can be a useful clue for the differential diagnosis of underdiagnosed entities and overlapping syndromes, such as eosinophilic granulomatosis with polyangiitis (EGPA), IgG4-related disease (IgG4-RD), acute interstitial nephritis (AIN), or the hypereosinophilic syndrome (HES). Read More

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http://dx.doi.org/10.3390/jcm7120529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306805PMC
December 2018
1 Read

Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies.

J Allergy Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Md. Electronic address:

Background: Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 is selectively expressed on eosinophils, mast cells, and basophils and, when engaged on eosinophils, can cause cell death.

Objective: We sought to characterize surface and soluble Siglec-8 (sSiglec-8) levels in normal donors (NDs) and eosinophilic donors (EOs) and assess the efficacy of anti-Siglec-8 antibodies in inducing eosinophil cell death in vitro.

Methods: Eosinophil expression of Siglec-8 was assessed by using flow cytometry and quantitative PCR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183174
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http://dx.doi.org/10.1016/j.jaci.2018.10.066DOI Listing
December 2018
13 Reads
11.476 Impact Factor

Hypereosinophilic syndrome: approach to treatment in the era of precision medicine.

Authors:
Amy Klion

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):326-331

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Hypereosinophilic syndromes (HESs) are a heterogeneous group of rare disorders characterized by peripheral eosinophilia and eosinophilic end organ complications. Conventional therapies, including glucocorticoids and cytotoxic and immunomodulatory agents, have variable efficacy and significant toxicity. Although the recent development of agents that target eosinophils, including tyrosine kinase inhibitors and monoclonal antibodies, provides the possibility of more effective, less toxic approaches to treatment of HES, there are little available data to guide their use in these conditions. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245960PMC
November 2018
2 Reads

Thrombosis in the portal venous system caused by hypereosinophilic syndrome: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13425

Department of Critical Care Medicine, Nantong Third People's Hospital, Nantong University.

Rationale: Extensive thrombosis in the portal venous system caused by hypereosinophilic syndrome (HES) is rare, and there is no consensus on anticoagulant and thrombolytic treatments for arteriovenous thrombosis caused by HES.

Patient Concerns: The clinical data of a patient with extensive thrombosis in his portal venous system (superior mesenteric, splenic, hepatic, and portal veins), renal artery thrombosis, and mesenteric thrombosis caused by HES with secondary gastrointestinal bleeding and intestinal necrosis were retrospectively analyzed. Before admission, his eosinophil count increased to 7. Read More

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http://dx.doi.org/10.1097/MD.0000000000013425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283207PMC
November 2018
15 Reads

What Are the Clinical Features and Etiology of Eosinophilic Liver Infiltration?

Gut Liver 2019 Jan 3. Epub 2019 Jan 3.

Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Background/aims: Although eosinophilic liver infiltration (ELI) is not rare, few data exist regarding its clinical characteristics and etiology. Therefore, we evaluated these aspects to better understand the clinical implications of this lesion type, which is reasonably common in Korea.

Methods: Patients suspected of having ELI, based on abdominal computed tomography results obtained between January 2010 and September 2017, were enrolled in this retrospective study. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
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http://dx.doi.org/10.5009/gnl18266DOI Listing
January 2019
15 Reads

[Vasculitides and eosinophilic pulmonary diseases].

Z Rheumatol 2018 Dec;77(10):907-922

Abt. für Rheumatologie, Immunologie und Rehabilitation, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Eosinophilic granulocytes form peripheral effector cells controlled by Th2 lymphocytes, which cause local cell, tissue, and functional disorders of infiltrated organs via the release of cytotoxic basic proteins and oxygen radicals. Diseases associated with eosinophilia include systemic and organ-related forms. The lungs are involved in eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome), acute and chronic eosinophilic pneumonia, as well as in an organ manifestation in hypereosinophilic syndrome and certain parasitic diseases. Read More

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http://link.springer.com/10.1007/s00393-018-0561-z
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http://dx.doi.org/10.1007/s00393-018-0561-zDOI Listing
December 2018
16 Reads

Diagnosis of systemic lupus erythematosus by presence of Hargraves cells in eosinophilic pleural effusion: Case report.

Medicine (Baltimore) 2018 Oct;97(42):e12871

Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland.

Rationale: Eosinophilic pleural effusion in elderly patients is most commonly due to malignancies and infections.

Patient Concerns: In rare cases, pleural eosinophilia is associated with connective tissue disease.

Diagnoses: Presence of Hargraves cells, also called lupus erythematosus (LE) cells (polynuclear cells that have engulfed denatured nuclear material), was a key point of American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) until 1997. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810190-0006
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http://dx.doi.org/10.1097/MD.0000000000012871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211931PMC
October 2018
6 Reads

Longitudinal stability of blood eosinophil count strata in the COPD COSYCONET cohort.

Int J Chron Obstruct Pulmon Dis 2018 28;13:2999-3002. Epub 2018 Sep 28.

Pulmonary Research Institute at Lungen Clinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Centre for Lung Research (DZL), Grosshansdorf, Germany.

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https://www.dovepress.com/longitudinal-stability-of-blood-eo
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http://dx.doi.org/10.2147/COPD.S165909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168004PMC
March 2019
3 Reads

C-Reactive protein as a diagnostic tool in differential diagnosis of hypereosinophilic syndrome and antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis.

J Allergy Clin Immunol Pract 2018 Oct 11. Epub 2018 Oct 11.

CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), University of Lille, Lille, France; Centre de Référence National des Syndromes Hyperéosinophiliques (CEREO), France; CHU Lille, Institut d'Immunologie, University of Lille, Lille, France; Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, University of Lille, Lille, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132198183065
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http://dx.doi.org/10.1016/j.jaip.2018.10.002DOI Listing
October 2018
17 Reads

Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers.

J Vet Intern Med 2018 Nov 12;32(6):2074-2081. Epub 2018 Oct 12.

Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Finland.

Background: Gastroesophageal reflux and microaspiration (MA) of gastric juice are associated with various human respiratory diseases but not in dogs.

Objective: To detect the presence of bile acids in bronchoalveolar lavage fluid (BALF) of dogs with various respiratory diseases.

Animals: Twenty-seven West Highland White Terriers (WHWTs) with canine idiopathic pulmonary fibrosis (CIPF), 11 dogs with bacterial pneumonia (BP), 13 with chronic bronchitis (CB), 9 with eosinophilic bronchopneumopathy (EBP), 19 with laryngeal dysfunction (LD), 8 Irish Wolfhounds (IWHs) with previous BPs, 13 healthy WHWTs, all privately owned dogs, and 6 healthy research colony Beagles METHODS: Prospective cross-sectional observational study with convenience sampling of dogs. Read More

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http://dx.doi.org/10.1111/jvim.15321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271311PMC
November 2018
2 Reads

Case report of hypereosinophilic syndrome presenting as severe ischaemic colitis.

ANZ J Surg 2018 Oct 2. Epub 2018 Oct 2.

Acute Surgical Unit, Division of Surgery, Logan Hospital, Logan City, Queensland, Australia.

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http://dx.doi.org/10.1111/ans.14894DOI Listing
October 2018
3 Reads

Omalizumab therapy in a patient with cronic spontaneous urticaria, ulcerative colitis, hypereosinophilia and prurigo Besnier: a case report.

J Dermatolog Treat 2018 ;29(sup3):10-13

a Dermatologic Clinic Sapienza University of Rome , Rome , Italy.

The case of a woman who suffered from CSU and prurigo Besnier, with a history of chronic hyper-eosinophilia, ulcerative colitis and thyroiditis, unresponsive to anti-histamines and steroids is reported. The patient received omalizumab treatment, and obtained resolution of urticaria along with improvement of cutaneous symptoms of prurigo. Read More

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http://dx.doi.org/10.1080/09546634.2018.1527990DOI Listing
January 2019
6 Reads

A rare case of hypereosinophilic syndrome presenting with unilateral proptosis and torticollis.

Indian J Ophthalmol 2018 Oct;66(10):1508-1511

Department of Oculoplasty, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

Hypereosinophilic syndrome (HES) is a spectrum of myeloproliferative disorder, which is characterized by persistent and marked blood eosinophilia and damage to multiple organs due to eosinophilic infiltration. Idiopathic HES is identified after ruling out all other causes of eosinophilia. Poor prognosis is usually associated with cardiac involvement and malignant transformation of blood cells. Read More

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http://dx.doi.org/10.4103/ijo.IJO_316_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173005PMC
October 2018
18 Reads

Acute pulmonary embolism and deep vein thrombosis secondary to idiopathic hypereosinophilic syndrome.

Respir Med Case Rep 2018 10;25:213-215. Epub 2018 Sep 10.

Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Acute pulmonary embolism (PE) is a most dangerous complication that needs prompt treatment to reduce potentially death. There are many well-known prognostic factors indicate the morbidity and mortality in various thromboembolic events. Persistent eosinophilia in peripheral blood can lead to tissue infiltration and even organ damage, but the urgent event of thromboembolism in pulmonary provoked by eosinophil eosinophilia in idiopathic hypereosinophilic syndrome (HES) is relative an unusual presentation. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143698PMC
September 2018
7 Reads

Eosinophilic Granulomatosis with Polyangiitis: Clinical Pathology Conference and Review.

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1496-1504

UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Eosinophilic granulomatosis with polyangiitis (EGPA) (formerly Churg-Strauss syndrome) is a small vessel vasculitis associated with asthma and eosinophilia. Despite its rarity, continuous gains are being made in understanding the disease with knowledge advancements regarding its epidemiology, heterogeneous clinical manifestations, management, and outcomes. Large knowledge gaps remain, however, particularly surrounding pathophysiologic and diagnostic uncertainties. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.07.001DOI Listing
May 2018
13 Reads

Eosinophils: Friends or Foes?

Authors:
Michael J Chusid

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1439-1444

Section of Pediatric Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wis. Electronic address:

The roles eosinophils are recognized to play in health and disease continue to evolve. Formerly, eosinophils were believed to fill a primary role in host defense against helminths, an intermediary one in the propagation of allergic conditions, and a pathologic one in clinical conditions characterized by systemic eosinophilia and eosinophilic infiltration of target organs. Eosinophils are increasingly understood to be positioned centrally within mammalian immune and inflammatory networks, possessing receptors for an array of inflammatory mediators and capable of producing numerous proinflammatory and homeostatic mediators. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.04.031DOI Listing
February 2018
3 Reads

[Acute idiopathic eosinophilic pneumonia in a teenager].

Rev Med Liege 2018 Sep;73(9):439-441

Service de Pneumologie pédiatrique, CHU UCL Namur (site de Dinant), Belgique.

Acute idiopathic eosinophilic pneumonia is a very rare cause of interstitial lung disease in children. Pathophysiological mechanisms and etiology remain poorly understood. It manifests as a febrile dyspnea, progressively worsening. Read More

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September 2018
13 Reads

Churg-Strauss Syndrome Presenting as Acute Necrotizing Eosinophilic Myocarditis: Concise Review of the Literature.

Curr Hypertens Rev 2019 ;15(1):8-12

Division of Cardiovascular Medicine, University of Southern California, Los Angeles-90033 CA, United States.

Background: Acute eosinophilic myocarditis (EM) is a rare form of heart failure that is characterized by myocardial eosinophilic infiltration usually in association with peripheral eosinophilia. The underlying cause is variable and can include allergic reactions, parasitic infection, idiopathic hypereosinophilic syndrome, malignancy, Loeffler's syndrome, Churg-Strauss syndrome (CSS), early giant cell myocarditis and malignancy. The course is potentially fatal, and early diagnosis and treatment with steroids is essential. Read More

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http://dx.doi.org/10.2174/1573402114666180903164900DOI Listing
January 2019
14 Reads

Endomyocardial Fibrosis With End-Stage Heart Failure as a Consequence of a Myeloproliferative Neoplasm With Hypereosinophilia.

Can J Cardiol 2018 Sep 5;34(9):1233.e13-1233.e15. Epub 2018 Jun 5.

Pathology Department, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Forensic Pathology, Central Branch, Instituto Nacional de Medicina Legal e Ciências Forenses, Coimbra, Portugal.

Hypereosinophilic syndrome is characterized by an overproduction of eosinophils that infiltrate and damage multiple organs. Cardiac dysfunction occurs frequently and is a main cause of morbidity and mortality. We describe the case of a middle-aged man diagnosed with a myeloproliferative neoplasm associated with hypereosinophilia and treated with imatinib. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.05.024DOI Listing
September 2018
18 Reads

Hypereosinophilic syndrome with cardiac involvement in a patient with multiple malignancies.

Med Ultrason 2018 Aug;20(3):399-400

"Carol Davila" University of Medicine and Pharmacy, Bucharest.

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http://dx.doi.org/10.11152/mu-1574DOI Listing
August 2018
3 Reads