5,674 results match your criteria Loeffler Endocarditis


Hypereosinophilic syndrome-a rare adverse event of anti-cytokine treatment in rheumatoid arthritis resolved after Janus kinase inhibitor therapy.

Clin Rheumatol 2020 Jun 3. Epub 2020 Jun 3.

1st Department of Internal Medicine, Faculty of Medicine, Comenius University in Bratislava and University Hospital Bratislava, Staré Mesto, Mickiewiczova 13, 813 69, Bratislava, Slovakia.

Eosinophilia is uncommon in early rheumatoid arthritis (RA). The most frequent causes of hypereosinophilia during RA treatment are atopic eczema, allergy, helminth infection, haematological malignancy and drug-associated complications. The pathogenesis of this abnormality associated with anti-cytokine therapy is still unknown. Read More

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http://dx.doi.org/10.1007/s10067-020-05134-zDOI Listing

Hypereosinophilia with Concurrent Venous Thromboembolism: Clinical Features, Potential Risk Factors, and Short-term Outcomes in a Chinese Cohort.

Sci Rep 2020 May 20;10(1):8359. Epub 2020 May 20.

Department of Emergency, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.

Idiopathic hypereosinophilia (IHE) and hypereosinophilic syndrome (HES) are benign haematological disorders. Studies have suggested that venous thromboembolism (VTE) is a rare but sometimes fatal complication of hypereosinophilia; however, data are limited. We retrospectively analysed clinical features and short-term outcomes of 63 consecutive patients (82. Read More

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http://dx.doi.org/10.1038/s41598-020-65128-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239859PMC

Paratrabecular myelofibrosis and occult mastocytosis are strong morphological clues to suspect translocation in hypereosinophilia.

Indian J Hematol Blood Transfus 2020 Apr 4;36(2):384-389. Epub 2019 Dec 4.

1Department of Hematology, Post Graduate Institute of Medical Education and Research, 5th floor, Research block A, Chandigarh, 160012 India.

To study the clinico-haematological and histopathological characteristics of rearranged hypereosinophilia/hypereosinophilic syndrome (F/P+ve HE/HES), a retrospective analysis of patients with F/P+ve HE diagnosed over a period of 43 months was performed. Peripheral blood smears, bone marrow aspirate (BMA) and biopsies (BMB) were reviewed in each case and; reticulin stain and immunohistochemistry for mast cell tryptase (MCT) and CD117 was performed. F/P+ve HE was diagnosed in a total of ten patients during study period. Read More

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http://dx.doi.org/10.1007/s12288-019-01236-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229073PMC
April 2020
0.234 Impact Factor

Medical Algorithm: Diagnosis and Treatment of Hypereosinophilic Syndrome.

Allergy 2020 May 16. Epub 2020 May 16.

Technical University of Munich, School of Medicine, Department of Dermatology and Allergy, Munich, Germany.

Hypereosinophilic syndrome (HES) is a group of rare disorders characterized by persistently elevated eosinophil count and eosinophil-mediated organ damage. The most frequent symptoms are cutaneous (e.g. Read More

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http://dx.doi.org/10.1111/all.14368DOI Listing

Symptom assessment in hypereosinophilic syndrome: toward development of a patient-reported outcomes tool.

J Allergy Clin Immunol Pract 2020 May 13. Epub 2020 May 13.

Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2020.04.069DOI Listing

Eosinophilic Dermatoses: Recognition and Management.

Am J Clin Dermatol 2020 May 11. Epub 2020 May 11.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Eosinophilic dermatoses encompass a broad spectrum of diseases of different etiologies hallmarked by eosinophilic infiltration of the skin and/or mucous membranes, with or without associated blood eosinophilia. The wide range of dermatological manifestations of this spectrum, including nodules and plaques, pustules, blisters, ulcers, and urticarial lesions, is reflected in a non-univocal classification system. We identified six groups of eosinophilic dermatoses based on the predominant anatomic level of involvement: (1) epidermal; (2) of the dermal-epidermal junction; (3) dermal; (4) of the hypodermis and muscle fascia; (5) of the pilosebaceous unit; and (6) vascular/perivascular. Read More

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http://dx.doi.org/10.1007/s40257-020-00520-4DOI Listing

An unusual presentation of Idiopathic hypereosinophilic syndrome.

J Thromb Thrombolysis 2020 May 6. Epub 2020 May 6.

Division of Neurology, Department of Medicine, National University Health System, Singapore, Singapore.

Hypereosinophilic syndrome (HES) is a rare but life-threatening multi-organ disease which can be complicated by stroke, with devastating outcomes. Eosinophils can accumulate in multiple organs, most commonly involving the heart, skin, lungs, spleen, and liver. Neurological end-organ complications in hypereosinophilic syndrome are unusual and have been established to be of three types: brain infarction, encephalopathy and sensory polyneuropathy. Read More

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http://dx.doi.org/10.1007/s11239-020-02127-2DOI Listing

Causes of hypereosinophilia in 100 consecutive patients.

Eur J Haematol 2020 May 4. Epub 2020 May 4.

Division of Hematology, University of British Columbia, Vancouver, BC, Canada.

Background: Hypereosinophilia (HE, persistent peripheral blood eosinophilia > 1.5 × 10 /L) and hypereosinophilic syndrome (HES, HE with end-organ damage) are classified as primary (due to a myeloid clone), secondary (due to a wide variety of reactive causes), or idiopathic. Diagnostic evaluation of eosinophilia is challenging, in part because secondary causes of HE/HES such as lymphocyte-variant HES (L-HES) and vasculitis are difficult to diagnose, and emerging causes such as immunoglobulin G4-related disease (IgG4-RD) have rarely been examined. Read More

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http://dx.doi.org/10.1111/ejh.13437DOI Listing

FIP1L1-PDGFRA-Positive Hypereosinophilia Presenting with Bilateral Extracranial Carotid Artery Aneurysms.

World Neurosurg 2020 Apr 29;139:419-422. Epub 2020 Apr 29.

Division of Adult Neurology, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

Objective: To describe a case of an adult female Filipino with hypereosinophilia and bilateral carotid artery aneurysms who subsequently developed bilateral cerebral hemisphere strokes following aneurysm stenting.

Case Description: A 57-year-old female patient with persistent hypereosinophilia presented with progressively enlarging bilateral neck masses, revealed to be carotid artery aneurysms on computed tomography angiography. Following surgical exploration, she later developed right-sided hemiplegia, aphasia, and right hemianopia. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.119DOI Listing

Recurrent hemorrhagic blisters: an atypical presentation of lymphocytic hypereosinophilic syndrome with cutaneous manifestations.

J Dtsch Dermatol Ges 2020 May 30;18(5):487-489. Epub 2020 Apr 30.

Department of Dermatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

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http://dx.doi.org/10.1111/ddg.14083DOI Listing

Single-Organ and Multisystem Hypereosinophilic Syndrome Patients with Gastrointestinal Manifestations Share Common Characteristics.

J Allergy Clin Immunol Pract 2020 Apr 25. Epub 2020 Apr 25.

Laboratory of Parasitic Diseases, NIAID, Bethesda, Md.

Background: Eosinophilic gastrointestinal diseases (EGIDs) are defined by marked eosinophilia in the gastrointestinal (GI) tract resulting in a wide variety of GI symptoms. When accompanied by blood hypereosinophilia (HE; absolute eosinophil count ≥1500/mm), EGID can occur as an isolated GI disorder (hypereosinophilic syndrome [HES]/EGID overlap) or as part of a multisystem hypereosinophilic syndrome (Multisystem HES).

Objective: To describe the GI disease of patients categorized as those with HES/EGID overlap versus those with Multisystem HES. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.04.025DOI Listing

Loeffler Endocarditis: A Manifestation of Hypereosinophilic Syndrome.

CASE (Phila) 2020 Apr 22;4(2):74-77. Epub 2019 Nov 22.

Department of Cardiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.case.2019.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175807PMC

A case of suspected eosinophilic myocarditis recognized by a fully noninvasive approach and safely treated with corticosteroids despite an underling Hepatitis C virus-hepatitis.

Future Cardiol 2020 Apr 22. Epub 2020 Apr 22.

Cardiovascular Disease Section, Emergency & Organs Transplantations Department, University of Bari 'A. Moro', Bari, Italy.

Hypereosinophilic syndrome can lead to acute myocarditis with a potentially severe systolic dysfunction and serious complications. A 75-year-old patient suffering from Hepatitis C virus (HCV) related-hepatitis came to our observation for idiopatic hypereosinophilic syndrome and acute severe cardiac systolic dysfunction without coronaropathy. Cardiac magnetic resonance showed a 'patchy' subendocardial and intramyocardial late gadolinium enhancement pattern often seen in eosinophilic myocarditis (EM). Read More

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http://dx.doi.org/10.2217/fca-2019-0032DOI Listing

Cough in hypereosinophilic syndrome: case report and literature review.

BMC Pulm Med 2020 Apr 15;20(1):90. Epub 2020 Apr 15.

National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, China.

Background: Cough and airway eosinophilic inflammation has not been highlighted in hypereosinophilic syndrome (HES).

Case Presentation: We report 2 further cases and reviewed the clinical features and treatment of HES present with cough from the literature. Both cases were middle age male, presenting with chronic cough, airway eosinophilic inflammation and hyper eosinophilia who have been previous misdiagnosed as cough-variant asthma and failed anti-asthma treatment. Read More

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http://dx.doi.org/10.1186/s12890-020-1134-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158094PMC

[Acute Eosinophilic Pneumonia (AEP) after Hookah Smoking].

Pneumologie 2020 Apr 9;74(4):230-233. Epub 2020 Apr 9.

Kliniken der Stadt Köln gGmbH, Lungenklinik-Merheim, ARDS und ECMO Zentrum, Universität Witten/Herdecke, Köln.

A 27-year-old, previously physically healthy man presented to an emergency department with an acute onset of thoracic pain, dyspnea, non-productive cough and fever. Hours before the onset of symptoms, the patient has smoked tobacco using a waterpipe (spearmint taste, not commercially available in Germany). Due to a progressive respiratory failure the patient required invasive mechanical ventilation. Read More

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http://dx.doi.org/10.1055/a-1115-6554DOI Listing

Distinguishment of parasite-infected children from pediatric inpatients with both eosinophilia and effusion.

Medicine (Baltimore) 2020 Apr;99(14):e19625

Department of Pediatrics, West China Second Hospital, Sichuan University.

Patients with both serous effusion and eosinophilia are rarely reported and geographically distributed; their early diagnosis is difficult.According to the ultimate diagnosis, patients (≤14 years) in West China Second hospital with serous effusion and eosinophilia were divided into two groups including a parasitic group and a non-parasitic group. Clinical data were collected and analyzed between the two groups. Read More

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http://dx.doi.org/10.1097/MD.0000000000019625DOI Listing

[Hypereosinophilic syndromes].

Rev Prat 2019 Sep;69(7):767-773

Centre de référence des syndromes hyperéosinophiliques (CEREO). Service de médecine interne, hôpital Ambroise-Paré, Boulogne-Billancourt ; université Versailles Saint-Quentin-en- Yvelines, France.

Hypereosinophilic syndromes. Hypereosinophilic syndromes (HES) is a protean condition defined by chronic blood eosinophilia ≥ 1.5 G/L (> 1 month) leading to eosinophilic-related organ damage. Read More

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September 2019

Idiopathic hypereosinophilic syndrome with formation of multiple liver mass lesions.

Clin J Gastroenterol 2020 Mar 30. Epub 2020 Mar 30.

Department of Gastroenterology, Japanese Red Cross Kyoto Daiichi Hospital, Hon-machi 15-749, Higashiyama-ku, Kyoto, 605-0981, Japan.

We report a case of idiopathic hypereosinophilic syndrome (IHES) characterized by multiple liver mass lesions in an 82-year-old man. Numerous hypoechoic lesions were observed on ultrasonography and were mainly distributed in the S4, S6, and S7 segments. Plain computed tomography (CT) scans revealed low-density lesions. Read More

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http://dx.doi.org/10.1007/s12328-020-01113-8DOI Listing

The Efficacy of Imatinib Mesylate in the Treatment of a Rare Lytic Bone Lesion Caused by Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia: A Case Report.

JBJS Case Connect 2020 Jan-Mar;10(1):e0126

Department of Orthopaedic Surgery, Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital, Hiroshima, Japan.

Case: We report a patient with hypereosinophilia-associated massive osteolytic lesion of the sacrum who was admitted to our hospital. Genetic analysis revealed that atypical eosinophilic cells were positive for FIP1-like-1-platelet-derived growth factor receptor-alpha (FIP1L1-PDGFRA) fusion gene. Treatment was initiated with oral administration of imatinib mesylate. Read More

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http://dx.doi.org/10.2106/JBJS.CC.19.00126DOI Listing

Peripheral Neuropathy Associated with Hypereosinophilic Syndrome: A Clinical Therapeutic Success with Capsaicin 8% Patch.

J Pain Palliat Care Pharmacother 2020 Mar 30:1-4. Epub 2020 Mar 30.

Ernesto F. M. Ruivo, M.D., Sandra V. S. Gestosa, M.D., Nídia M. E. Mulenas, M.D., and Ana M. G. Lares, M.D. are in the Department of Pain Management, Department of Anaesthesiology, University Hospital Centre of Algarve, Faro, Portugal.

Neuropathic pain is defined as a direct consequence of an injury or disease that affects the somatosensory system, which may affect 7 to 10% of the world population. Regardless of its origin, it is often described as disabling, chronic, difficult to treat and with a noticeable impact on patients' quality of life. This case report describes a patient with peripheral polyneuropathy associated with hypereosinophilic syndrome, a medical condition scarcely described in literature. Read More

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http://dx.doi.org/10.1080/15360288.2020.1734145DOI Listing

Eosinophilic pancreatitis: a rare or unexplored disease entity?

Prz Gastroenterol 2020 3;15(1):34-38. Epub 2020 Mar 3.

Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Centre, Tulane University School of Medicine, New Orleans, LA, USA.

Several case reports show accumulation of eosinophils in pancreatitis patients and term the disease as "eosinophilic pancreatitis (EP)". EP usually presents with a pancreatic tumour and abdominal pain in obstructive jaundice, which is generally not diagnosed until the patient undergoes pancreatic resection. Histologically, EP reveals distinct patterns like diffused, periductal, acinar, and septal inflammatory infiltrates with eosinophils, eosinophilic phlebitis, and localised extreme eosinophilic infiltrates related with pseudocyst formation. Read More

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http://dx.doi.org/10.5114/pg.2019.90631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089860PMC
March 2020
0.375 Impact Factor

Correction to: Targeted Anti-IL-5 Therapies and Future Therapeutics for Hypereosinophilic Syndrome and Rare Eosinophilic Conditions.

Clin Rev Allergy Immunol 2020 Mar 18. Epub 2020 Mar 18.

Division of Allergy and Immunology, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 1020 Youngs Road, Williamsville, NY, 14221, USA.

The original version of this article unfortunately contained a mistake in the fifth paragraph of the "Conclusion" section. Read More

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http://dx.doi.org/10.1007/s12016-020-08781-xDOI Listing

Myocarditis and Eosinophilia: Three Cases of Hypereosinophilic Syndrome and Myocarditis.

CJC Open 2019 Mar 29;1(2):100-102. Epub 2019 Mar 29.

Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada.

Eosinophilic infiltration is a rare and underrecognized cause of myocarditis associated with prolonged eosinophilia. Before advanced imaging and routine biopsy, patients were diagnosed with an idiopathic cardiomyopathy with subsequent diagnosis made on autopsy. We present 3 cases of eosinophilic myocarditis diagnosed by cardiac biopsy classified as hypereosinophilic syndrome. Read More

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http://dx.doi.org/10.1016/j.cjco.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063606PMC

Lymphocytic variant of hypereosinophilic syndrome: A report of seven cases from a single institution.

Cytometry B Clin Cytom 2020 Mar 11. Epub 2020 Mar 11.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Lymphocytic variant of hypereosinophilic syndrome (L-HES) is a subtype of HES driven by cytokines produced by clonal T-cells. Due to the rarity of its occurrence and challenges in diagnosis, this subtype of HES is under recognized.

Methods And Results: We report seven patients with L-HES, diagnosed from a group of 136 patients who were referred to our institution for the work-up of hypereosinophilia. Read More

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http://dx.doi.org/10.1002/cyto.b.21874DOI Listing
March 2020
2.283 Impact Factor

The Effect of Mepolizumab on the Lungs in a Boy with Hypereosinophilic Syndrome.

Am J Respir Crit Care Med 2020 Mar 9. Epub 2020 Mar 9.

Tel Aviv Ichilov-Sourasky Medical Center, 26738, Tel Aviv, Israel.

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http://dx.doi.org/10.1164/rccm.201907-1376IMDOI Listing

Development of Eosinophilic Temporal Arteritis and Digital Ischemia in a Patient with Hypereosinophilic Syndrome.

Intern Med 2020 May 26;59(10):1323-1330. Epub 2020 Feb 26.

Department of Rheumatology, Tokyo Medical University Hospital, Japan.

We describe a case of eosinophilic temporal arteritis in a 61-year-old woman with hypereosinophilic syndrome, who developed subcutaneous nodules in the temporal areas and digital cyanosis with small nodules on the sides of her fingers. Ultrasound revealed occlusion and corkscrew-like changes of the temporal and digital arteries, respectively. Temporal artery biopsy revealed eosinophilic vasculitis without giant cell formation. Read More

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http://dx.doi.org/10.2169/internalmedicine.3707-19DOI Listing

Eosinophilic asthma with chronic rhinosinusitis/nasal polyps and biologic agents.

Authors:
İnsu Yilmaz

Tuberk Toraks 2019 Dec;67(4):292-299

Division of Immunology and Allergic Diseases, Department of Chest Diseases, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

The current understanding in severe asthma management is the targeted therapy approach with the evaluation of phenotypes and biomarkers. Therefore, personalized treatments are recently more prominent. Eosinophilic asthma with chronic rhinosinusitis/nasal polyps (CRSwNP) is one of the severe asthma phenotypes which needs a personalized treatment approach. Read More

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http://dx.doi.org/10.5578/tt.68953DOI Listing
December 2019

Hypereosinophilia with angioimmunoblastic T-cell lymphoma.

Ann Allergy Asthma Immunol 2020 05 8;124(5):513-515. Epub 2020 Feb 8.

Department of Allergy and Immunology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1016/j.anai.2020.01.028DOI Listing

Dramatic and Durable Responses to Romidepsin in Two Patients With the Lymphocytic Variant of Hypereosinophilic Syndrome.

Clin Lymphoma Myeloma Leuk 2020 Mar 9;20(3):e128-e130. Epub 2019 Nov 9.

Division of Hematology, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2019.11.006DOI Listing

A systems biology approach for defining the potential molecular framework of idiopathic hypereosinophilic syndrome with cutaneous involvement.

Biochem Biophys Res Commun 2020 Apr 1;524(3):567-574. Epub 2020 Feb 1.

Department of Dermatology, PLA General Hospital, Beijing, China. Electronic address:

Hypereosinophilic syndrome (HES) is a rare multisystem disease that predominantly includes skin with severe and persistent itching. A lack of understanding about the pathological condition and mechanism of dermatosis caused by HES hinders its treatment. In the present study, we applied a quantitative proteomics approach to characterize the cellular responses of skin tissue to idiopathic HES (IHES) at the proteome level. Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.01.131DOI Listing

Hypereosinophilic Syndrome Masquerading as Complicated Pneumonia.

Indian J Pediatr 2020 Feb 1. Epub 2020 Feb 1.

Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India.

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http://dx.doi.org/10.1007/s12098-020-03197-zDOI Listing
February 2020

Ascites in a young male: idiopathic FIP1L1-PDGFRA-negative hypereosinophilic syndrome.

JRSM Open 2020 Jan 15;11(1):2054270419894826. Epub 2020 Jan 15.

Department of Hematology, Ampang Hospital, Jalan Mewah Utara, Pandan Mewah, 68000 Ampang, Selangor, Malaysia.

Introduction: Idiopathic hypereosinophilic syndrome is defined as persistently elevated peripheral blood absolute eosinophil count of more than 1.5 × 109/L for at least six months with no obvious secondary cause.

Case Presentation: We report the case of a 26-year-old gentleman of Malay ethnicity who presented to the medical department with a three-week history of abdominal distension associated with dyspepsia and epigastric pain. Read More

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http://dx.doi.org/10.1177/2054270419894826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963322PMC
January 2020

Systemic hypereosinophilic syndromes: when autoimmunity is Th2 mediated.

Curr Opin Allergy Clin Immunol 2020 Apr;20(2):175-180

Immunoallergology Unit, AOU Careggi, University of Florence, Florence.

Purpose Of Review: Clinical conditions associated with hypereosinophilia represent a field of particular interest, taking into account the epidemiological impact of the different primary and secondary forms. In addition to a classical Th1 response, also Th2 cells can be involved in the pathogenesis of autoimmune diseases, among them eosinophilic forms such as eosinophilic granulomatosis with polyangiitis.

Recent Findings: In patients with severe asthma, recent evidence highlights the role of pathogenic autoantibodies against autologous eosinophil proteins (e. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000614DOI Listing

[Left ventricular deformation in cardiac light-chain amyloidosis and hypereosinophilic syndrome. ].

Orv Hetil 2020 02;161(5):169-176

Szent-Györgyi Albert Klinikai Központ, II. Belgyógyászati Klinika és Kardiológiai Központ, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6725.

Hypereosinophilic syndrome (HES) and immunoglobulin light-chain amyloidosis (ALA) are two, rare haematological disorders associated with cardiac alterations. The goal of the present study was a comparative assessment of left ventricular (LV) deformational parameters in HES and ALA patients using three-dimensional speckle-tracking echocardiography (3DSTE). In the present study, results of 10 HES patients (mean age: 60. Read More

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http://dx.doi.org/10.1556/650.2020.31584DOI Listing
February 2020

Contributions of Eosinophils to Human Health and Disease.

Annu Rev Pathol 2020 01;15:179-209

Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA; email:

The human eosinophil has long been thought to favorably influence innate mucosal immunity but at times has also been incriminated in disease pathophysiology. Research into eosinophil biology has uncovered a number of interesting contributions by eosinophils to health and disease. However, it appears that not all eosinophils from all species are created equal. Read More

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http://dx.doi.org/10.1146/annurev-pathmechdis-012419-032756DOI Listing
January 2020

A man with abdominal pain and eosinophilia : tissue is the issue.

Acta Gastroenterol Belg 2019 Oct-Dec;82(4):532-535

Department of Gastro-enterology AZ Sint Lucas, Ghent, Belgium.

A 24-year-old male presented with abdominal pain, postprandial vomiting and weight loss. Lab results showed an elevated serum eosinophil count and CT-scan demonstrated a thickened antral, duodenal and jejunal wall. Repetitive endoscopic mucosal biopsies were normal. Read More

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February 2020

Eosinophilic Vasculitis.

Curr Rheumatol Rep 2020 Jan 11;22(1). Epub 2020 Jan 11.

Section of Rheumatology, LSU Health Sciences Center, New Orleans, LA, 70112, USA.

Purpose Of Review: Eosinophilic granulomatosis with polyangiitis (EGPA) represents a rare clinical entity, which is getting increasing attention and relevance in view of our better understanding and newer insights into its pathogenesis. Concomitantly better recognition and understanding of the immune pathophysiologic role of eosinophils provide a solid ground of their role on systemic inflammatory disorders and defense against infectious triggers, especially parasites. This review will focus on describing the physiopathology of eosinophils, as well as providing an in depth description of the natural history, clinical spectrum, and therapy of EGPA. Read More

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http://dx.doi.org/10.1007/s11926-020-0881-2DOI Listing
January 2020

Targeted Anti-IL-5 Therapies and Future Therapeutics for Hypereosinophilic Syndrome and Rare Eosinophilic Conditions.

Clin Rev Allergy Immunol 2020 Jan 9. Epub 2020 Jan 9.

Division of Allergy and Immunology, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 1020 Youngs Road, Williamsville, NY, 14221, USA.

Eosinophilic inflammation is a component of many atopic diseases such as asthma, and biologics targeting eosinophils have been shown to be effective in subsets of these patients. However, there also are conditions in which eosinophils are the key inflammatory cells responsible for driving tissue damage. In these eosinophilic diseases such as hyper-eosinophilic syndrome, eosinophilic esophagitis, and eosinophilic granulomatosis with polyangiitis (EGPA), the development of biologics inhibiting eosinophilic inflammation have offered targeted therapeutic strategies for patients that have not responded well to typical first line drugs, which often have significant adverse side effects with poor disease modification or recurrent relapse with significant morbidity. Read More

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http://dx.doi.org/10.1007/s12016-019-08775-4DOI Listing
January 2020

[Complete remission of Loeffler's endocarditis with Imatinib in a myeloid and lymphoid neoplasm associated with eosinophilia].

Dtsch Med Wochenschr 2020 01 8;145(1):36-39. Epub 2020 Jan 8.

Klinik III für Innere Medizin, Herzzentrum, Universität zu Köln.

History And Clinical Findings: A 53-year-old male presented with massive pruritus, whole-body exanthema, generalized muscle pain, and exercise dyspnoea NYHA II.

Findings And Diagnosis: Further hematologic examination lead to diagnosis of myeloid and lymphoid neoplasia with eosinophilia (MLN-EO) with FIPL1L1-PDGFRA fusion gene. An echocardiographic examination revealed a thrombus in the right ventricle. Read More

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http://dx.doi.org/10.1055/a-0977-8779DOI Listing
January 2020

Multiple Biological Aspects of Eosinophils in Host Defense, Eosinophil-Associated Diseases, Immunoregulation, and Homeostasis: Is Their Role Beneficial, Detrimental, Regulator, or Bystander?

Biol Pharm Bull 2020 ;43(1):20-30

Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University.

Eosinophils are innate immune leukocytes and play important roles as terminal effector cells owing to their mediators, such as tissue-destructive cationic proteins, cytokines, chemokines, and lipid mediators. Historically, they are not only considered an important player in host defense against parasitic, viral, fungal, and bacterial infections but also implicated in the pathogenesis of eosinophil-associated diseases, such as allergic rhinitis, asthma, eosinophilic chronic rhinosinusitis, esophagitis, atopic dermatitis, myopathies, and hypereosinophilic syndrome. Moreover, recent studies have shown that eosinophils have an immune regulatory and homeostatic function. Read More

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http://dx.doi.org/10.1248/bpb.b19-00892DOI Listing
January 2020

When multimodality cardiac imaging saves the day: rare cause of embolic strokes.

BMJ Case Rep 2020 Jan 2;13(1). Epub 2020 Jan 2.

Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

Hypereosinophilic syndrome (HES) is a rare disorder characterised by eosinophilic infiltration of tissues. Myocardial infiltration occurs in 50%-60% of HES and leads to a condition called Loeffler's endocarditis. This can lead to endomyocardial injury with resultant superimposed thrombus formation and embolic stroke. Read More

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http://dx.doi.org/10.1136/bcr-2019-232786DOI Listing
January 2020

A case report of a 40-year-old woman with endomyocardial fibrosis in a non-tropical area: from initial presentation to high urgent heart transplantation.

BMC Cardiovasc Disord 2019 12 19;19(1):302. Epub 2019 Dec 19.

Department of Internal Medicine 3, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, Dunantplatz 1, 3100, St. Poelten, Austria.

Background: Endomyocardial fibrosis (EMF) represents the most common cause of restrictive cardiomyopathy worldwide. Despite a high prevalence in tropical regions, it occasionally occurs in patients who have never visited these areas. While researches have proposed various possible triggers for EMF, etiology and pathogenesis remain largely unknown. Read More

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http://dx.doi.org/10.1186/s12872-019-1243-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933894PMC
December 2019

Not just another kinase mutation!

Blood 2019 12;134(26):2335-2337

INSERM; Université Paris-Saclay; Gustave Roussy.

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http://dx.doi.org/10.1182/blood.2019003650DOI Listing
December 2019

"Idiopathic Eosinophilic Vasculitis": Another Side of Hypereosinophilic Syndrome? A Comprehensive Analysis of 117 Cases in Asthma-Free Patients.

J Allergy Clin Immunol Pract 2020 Apr 18;8(4):1329-1340.e3. Epub 2019 Dec 18.

Centre de Référence National des Syndromes Hyperéosinophiliques (CEREO), Lille, France; Hôpital Ambroise Paré, Service de Médecine Interne, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, France.

Background: The absence of asthma may rule out a diagnosis of eosinophilic granulomatosis with polyangiitis in patients with hypereosinophilic syndrome (HES) and features of vasculitis.

Objective: To describe eosinophilic vasculitis (EoV) as a possible manifestation of HES in asthma-free patients.

Methods: We screened our hospital database and the literature for patients with HES who met the following 4 criteria: (1) histopathological or clinical features of EoV (biopsy-proven vasculitis with predominant eosinophilic infiltration of the vessel wall and/or features of vasculitis with tissue and/or blood hypereosinophilia [absolute eosinophil count >1. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.12.011DOI Listing

[Analysis of the clinical features and misdiagnosis reasons of 17 patients misdiagnosed with IgG4-related disease].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Dec;51(6):1025-1031

Department of Rheumatology & Immunology, Peking University People's Hospital, Beijing 100044, China.

Objective: To summarize the clinical characteristics of patients misdiagnosed with IgG4-related disease, to analyze the reasons of misdiagnosis and to improve the clinical recognition of the disease.

Methods: The general data, clinical manifestations, laboratory examination results and pathological features of 17 patients with IgG4-related diseases misdiagnosed outside the hospital were retrospectively analyzed.

Results: Among the 17 patients, there were 9 males and 8 females with a median age of 45 years, and the median time from onset to diagnosis was 12 months. Read More

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December 2019

Viral Pneumonia Requiring Differentiation from Acute and Progressive Diffuse Interstitial Lung Diseases.

Intern Med 2019 15;58(24):3509-3519. Epub 2019 Dec 15.

Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.

Objective The clinical characteristics and chest imaging findings of viral pneumonia and several interstitial lung diseases (ILDs) overlap, and viral pneumonia may be underrecognized and misdiagnosed as certain ILDs. To clarify the frequency of viral pneumonia among patients with acute progressive clinical courses that required a differential diagnosis between ILDs and pneumonia, and to determine the most frequent ILDs misdiagnosed in cases of viral pneumonia. Patients and Methods We retrospectively analyzed patients hospitalized from 2010 to 2017 with an acute clinical course (≤30 days) who underwent bronchoalveolar lavage (BAL) for the differential diagnosis of infection and ILDs. Read More

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http://dx.doi.org/10.2169/internalmedicine.2696-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949447PMC