5,392 results match your criteria Loeffler Endocarditis


[Differential diagnosis of hypereosinophilia].

Z Rheumatol 2019 Jan 11. Epub 2019 Jan 11.

Vaskulitiszentrum-Süd, Klinik für Innere Medizin, Rheumatologie und Immunologie, Medius Kliniken, Akademisches Lehrkrankenhaus, Universität Tübingen, Kirchheim u. Teck, Deutschland.

Eosinophilia is defined as an elevated absolute number of eosinophilic leukocytes in peripheral blood or tissue. Its absolute number also defines the grade of eosinophilia. The main causes are allergic (including drug side effects) and infectious triggers but malignant and autoimmune diseases can also result in eosinophilia. Read More

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http://dx.doi.org/10.1007/s00393-018-0587-2DOI Listing
January 2019

[Chronic myeloid leukemia presenting with marked eosinophilia].

Rinsho Ketsueki 2018 ;59(12):2594-2599

Department of Hematology, Tonan Hospital.

An 80-year-old female with fever, edema in the lower extremities, and marked eosinophilia was referred to our hospital. Based on the presence of the Philadelphia chromosome, she was diagnosed with chronic myeloid leukemia (CML). Although imatinib induced a complete cytogenetic response (CCyR), CML relapsed after 28 months of starting it. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/12/59_2594/
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http://dx.doi.org/10.11406/rinketsu.59.2594DOI Listing
January 2018
2 Reads

Chronic eosinophilic pneumonia after trastuzumab and radiation therapy for breast cancer: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e14017

Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Rationale: Chronic eosinophilic pneumonia (CEP) is rare and an idiopathic disorder. The disease has been associated with drugs, infection, or irradiation, and its relationship with asthma remains unclear.

Patient Concerns: We reported a case of a 49-year-old female patient after trastuzumab and radiation therapy for breast cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014017DOI Listing
January 2019
1 Read

Mepolizumab as the first targeted treatment for eosinophilic granulomatosis with polyangiitis: a review of current evidence and potential place in therapy.

Ther Clin Risk Manag 2018 7;14:2385-2396. Epub 2018 Dec 7.

School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy,

Mepolizumab is an anti-interleukin-5 (IL-5) humanized monoclonal antibody that binds to free IL-5. It induces bone marrow eosinophil maturation arrest and decreases eosinophil progenitors and subsequent maturation in the blood and bronchial mucosa. Its use has been extensively studied in severe eosinophilic asthma at a dose of 100 mg subcutaneously (SC) every 4 weeks and, more recently, in other hypereosinophilic syndromes. Read More

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https://www.dovepress.com/mepolizumab-as-the-first-targeted-
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http://dx.doi.org/10.2147/TCRM.S159949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292233PMC
December 2018
4 Reads

Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia.

Leukemia 2018 Dec 20. Epub 2018 Dec 20.

Faculty of Medicine, University of Southampton, Southampton, UK.

Determining the underlying cause of persistent eosinophilia is important for effective clinical management but remains a diagnostic challenge in many cases. We identified STAT5B N642H, an established oncogenic mutation, in 27/1715 (1.6%) cases referred for investigation of eosinophilia. Read More

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http://www.nature.com/articles/s41375-018-0342-3
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http://dx.doi.org/10.1038/s41375-018-0342-3DOI Listing
December 2018
3 Reads

Advances in diagnosis of mastocytosis and hypereosinophilic syndrome.

Semin Hematol 2019 Jan 28;56(1):22-29. Epub 2018 May 28.

Hematology Section, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1508.

Mastocytosis and hypereosinophilic syndrome is very rare neoplastic hematopoietic diseases. Mastocytosis is characterized by expansion and accumulation of clonal tissue mast cells in skin and/or various internal organs, while hypereosinophilic syndrome manifests with an increased number of eosinophils in the peripheral blood and tissue damage. These diseases represent a diagnostic challenge, since they can have overlapping clinical and pathologic features. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00371963183003
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http://dx.doi.org/10.1053/j.seminhematol.2018.05.005DOI Listing
January 2019
4 Reads

Hypereosinophilia: a diagnostic challenge.

Neth J Med 2018 Dec;76(10):431-436

Harbour Hospital and Institute for Tropical Diseases, Rotterdam, the Netherlands (currently working at Albert Schweitzer Hospital, Rotterdam).

Hypereosinophilia encompasses a broad differential diagnosis of atopy/allergic reactions, drug reactions, parasitic infections and paraneoplastic syndromes. Although mostly of limited clinical significance, hypereosinophilia can also be related to hematological malignancies. One has to be aware of the potential for secondary organ damage for example, in the case of hypereosinophilic syndrome. Read More

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December 2018
1 Read

Idiopathic hypereosinophilic syndrome with cutaneous involvement: a comparative review of 32 cases.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.

Although idiopathic hypereosinophilic syndrome (HES) is uncommon, we studied the clinical characteristics of this disorder in patients with cutaneous involvement. We chronicle the case of a patient with diffuse skin rash due to idiopathic HES from our clinical experience. Furthermore, a systematic literature search of the medical databases PubMed and Google Scholar was conducted. Read More

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http://dx.doi.org/10.1136/bcr-2018-227137DOI Listing
December 2018

The epidemiology and clinical characteristics of myeloproliferative neoplasms in Malaysia.

Exp Hematol Oncol 2018 17;7:31. Epub 2018 Dec 17.

Department of Haematology, Sunway Medical Centre, Kuala Lumpur, Malaysia.

Background: The evolution of molecular studies in myeloproliferative neoplasms (MPN) has enlightened us the understanding of this complex disease consisting of polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). The epidemiology is well described in the western world but not in Asian countries like Malaysia.

Materials And Methods: This retrospective national registry of MPN was conducted from year 2009 to 2015 in Malaysia. Read More

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https://ehoonline.biomedcentral.com/articles/10.1186/s40164-
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http://dx.doi.org/10.1186/s40164-018-0124-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296047PMC
December 2018
11 Reads

Eosinophilia and Kidney Disease: More than Just an Incidental Finding?

J Clin Med 2018 Dec 8;7(12). Epub 2018 Dec 8.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, 6020 Innsbruck, Austria.

Peripheral blood eosinophilia (PBE), defined as 500 eosinophils or above per microliter (µL) blood, is a condition that is not uncommon but often neglected in the management of patients with chronic kidney disease (CKD), acute kidney injury (AKI), or patients on renal replacement therapy (RRT). The nature of PBE in the context of kidney diseases is predominantly secondary or reactive and has to be distinguished from primary eosinophilic disorders. Nonetheless, the finding of persistent PBE can be a useful clue for the differential diagnosis of underdiagnosed entities and overlapping syndromes, such as eosinophilic granulomatosis with polyangiitis (EGPA), IgG4-related disease (IgG4-RD), acute interstitial nephritis (AIN), or the hypereosinophilic syndrome (HES). Read More

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http://dx.doi.org/10.3390/jcm7120529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306805PMC
December 2018
1 Read

Siglec-8 in eosinophilic disorders: receptor expression and targeting using chimeric antibodies.

J Allergy Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, MD. Electronic address:

Background: Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is selectively expressed on eosinophils, mast cells and basophils, and, when engaged on eosinophils, can cause cell death.

Objective: To characterize surface and soluble Siglec-8 levels in normal (ND) and eosinophilic (EO) subjects and assess the efficacy of anti-Siglec-8 antibodies in inducing eosinophil cell death in vitro.

Methods: Eosinophil expression of Siglec-8 was assessed using flow cytometry and quantitative PCR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183174
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http://dx.doi.org/10.1016/j.jaci.2018.10.066DOI Listing
December 2018
3 Reads
11.476 Impact Factor

Hypereosinophilic syndrome: approach to treatment in the era of precision medicine.

Authors:
Amy Klion

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):326-331

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Hypereosinophilic syndromes (HESs) are a heterogeneous group of rare disorders characterized by peripheral eosinophilia and eosinophilic end organ complications. Conventional therapies, including glucocorticoids and cytotoxic and immunomodulatory agents, have variable efficacy and significant toxicity. Although the recent development of agents that target eosinophils, including tyrosine kinase inhibitors and monoclonal antibodies, provides the possibility of more effective, less toxic approaches to treatment of HES, there are little available data to guide their use in these conditions. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245960PMC
November 2018
1 Read

Thrombosis in the portal venous system caused by hypereosinophilic syndrome: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13425

Department of Critical Care Medicine, Nantong Third People's Hospital, Nantong University.

Rationale: Extensive thrombosis in the portal venous system caused by hypereosinophilic syndrome (HES) is rare, and there is no consensus on anticoagulant and thrombolytic treatments for arteriovenous thrombosis caused by HES.

Patient Concerns: The clinical data of a patient with extensive thrombosis in his portal venous system (superior mesenteric, splenic, hepatic, and portal veins), renal artery thrombosis, and mesenteric thrombosis caused by HES with secondary gastrointestinal bleeding and intestinal necrosis were retrospectively analyzed. Before admission, his eosinophil count increased to 7. Read More

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http://dx.doi.org/10.1097/MD.0000000000013425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283207PMC
November 2018
9 Reads

What Are the Clinical Features and Etiology of Eosinophilic Liver Infiltration?

Gut Liver 2019 Jan 3. Epub 2019 Jan 3.

Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Background/aims: Although eosinophilic liver infiltration (ELI) is not rare, few data exist regarding its clinical characteristics and etiology. Therefore, we evaluated these aspects to better understand the clinical implications of this lesion type, which is reasonably common in Korea.

Methods: Patients suspected of having ELI, based on abdominal computed tomography results obtained between January 2010 and September 2017, were enrolled in this retrospective study. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
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http://dx.doi.org/10.5009/gnl18266DOI Listing
January 2019
8 Reads

[Vasculitides and eosinophilic pulmonary diseases].

Z Rheumatol 2018 Dec;77(10):907-922

Abt. für Rheumatologie, Immunologie und Rehabilitation, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Eosinophilic granulocytes form peripheral effector cells controlled by Th2 lymphocytes, which cause local cell, tissue, and functional disorders of infiltrated organs via the release of cytotoxic basic proteins and oxygen radicals. Diseases associated with eosinophilia include systemic and organ-related forms. The lungs are involved in eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome), acute and chronic eosinophilic pneumonia, as well as in an organ manifestation in hypereosinophilic syndrome and certain parasitic diseases. Read More

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http://link.springer.com/10.1007/s00393-018-0561-z
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http://dx.doi.org/10.1007/s00393-018-0561-zDOI Listing
December 2018
10 Reads

Diagnosis of systemic lupus erythematosus by presence of Hargraves cells in eosinophilic pleural effusion: Case report.

Medicine (Baltimore) 2018 Oct;97(42):e12871

Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland.

Rationale: Eosinophilic pleural effusion in elderly patients is most commonly due to malignancies and infections.

Patient Concerns: In rare cases, pleural eosinophilia is associated with connective tissue disease.

Diagnoses: Presence of Hargraves cells, also called lupus erythematosus (LE) cells (polynuclear cells that have engulfed denatured nuclear material), was a key point of American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) until 1997. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810190-0006
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http://dx.doi.org/10.1097/MD.0000000000012871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211931PMC
October 2018
5 Reads

C-Reactive protein as a diagnostic tool in differential diagnosis of hypereosinophilic syndrome and antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis.

J Allergy Clin Immunol Pract 2018 Oct 11. Epub 2018 Oct 11.

CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), University of Lille, Lille, France; Centre de Référence National des Syndromes Hyperéosinophiliques (CEREO), France; CHU Lille, Institut d'Immunologie, University of Lille, Lille, France; Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, University of Lille, Lille, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132198183065
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http://dx.doi.org/10.1016/j.jaip.2018.10.002DOI Listing
October 2018
8 Reads

Case report of hypereosinophilic syndrome presenting as severe ischaemic colitis.

ANZ J Surg 2018 Oct 2. Epub 2018 Oct 2.

Acute Surgical Unit, Division of Surgery, Logan Hospital, Logan City, Queensland, Australia.

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http://dx.doi.org/10.1111/ans.14894DOI Listing
October 2018
2 Reads

A rare case of hypereosinophilic syndrome presenting with unilateral proptosis and torticollis.

Indian J Ophthalmol 2018 Oct;66(10):1508-1511

Department of Oculoplasty, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

Hypereosinophilic syndrome (HES) is a spectrum of myeloproliferative disorder, which is characterized by persistent and marked blood eosinophilia and damage to multiple organs due to eosinophilic infiltration. Idiopathic HES is identified after ruling out all other causes of eosinophilia. Poor prognosis is usually associated with cardiac involvement and malignant transformation of blood cells. Read More

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http://dx.doi.org/10.4103/ijo.IJO_316_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173005PMC
October 2018
14 Reads

Acute pulmonary embolism and deep vein thrombosis secondary to idiopathic hypereosinophilic syndrome.

Respir Med Case Rep 2018 10;25:213-215. Epub 2018 Sep 10.

Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Acute pulmonary embolism (PE) is a most dangerous complication that needs prompt treatment to reduce potentially death. There are many well-known prognostic factors indicate the morbidity and mortality in various thromboembolic events. Persistent eosinophilia in peripheral blood can lead to tissue infiltration and even organ damage, but the urgent event of thromboembolism in pulmonary provoked by eosinophil eosinophilia in idiopathic hypereosinophilic syndrome (HES) is relative an unusual presentation. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143698PMC
September 2018
3 Reads

Eosinophilic Granulomatosis with Polyangiitis: Clinical Pathology Conference and Review.

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1496-1504

UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Eosinophilic granulomatosis with polyangiitis (EGPA) (formerly Churg-Strauss syndrome) is a small vessel vasculitis associated with asthma and eosinophilia. Despite its rarity, continuous gains are being made in understanding the disease with knowledge advancements regarding its epidemiology, heterogeneous clinical manifestations, management, and outcomes. Large knowledge gaps remain, however, particularly surrounding pathophysiologic and diagnostic uncertainties. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.07.001DOI Listing
May 2018
7 Reads

Eosinophils: Friends or Foes?

Authors:
Michael J Chusid

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1439-1444

Section of Pediatric Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wis. Electronic address:

The roles eosinophils are recognized to play in health and disease continue to evolve. Formerly, eosinophils were believed to fill a primary role in host defense against helminths, an intermediary one in the propagation of allergic conditions, and a pathologic one in clinical conditions characterized by systemic eosinophilia and eosinophilic infiltration of target organs. Eosinophils are increasingly understood to be positioned centrally within mammalian immune and inflammatory networks, possessing receptors for an array of inflammatory mediators and capable of producing numerous proinflammatory and homeostatic mediators. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.04.031DOI Listing
February 2018
2 Reads

[Acute idiopathic eosinophilic pneumonia in a teenager].

Rev Med Liege 2018 Sep;73(9):439-441

Service de Pneumologie pédiatrique, CHU UCL Namur (site de Dinant), Belgique.

Acute idiopathic eosinophilic pneumonia is a very rare cause of interstitial lung disease in children. Pathophysiological mechanisms and etiology remain poorly understood. It manifests as a febrile dyspnea, progressively worsening. Read More

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September 2018
10 Reads

Churg-Strauss Syndrome Presenting As Acute Necrotizing Eosinophilic Myocarditis. Concise review of the literature.

Curr Hypertens Rev 2018 Sep 3. Epub 2018 Sep 3.

Division of Cardiovascular Medicine, University of Southern California, Los Angeles-90033 CA. United States.

Acute eosinophilic myocarditis (EM) is a rare form of heart failure that is characterized by myocardial eosinophilic infiltration usually in association with peripheral eosinophilia. The underlying cause is variable and can include allergic reactions, parasitic infection, idiopathic hypereosinophilic syndrome, malignancy, Loeffler's syndrome, Churg-Strauss syndrome (CSS), early giant cell myocarditis and malignancy. The course is potentially fatal, and early diagnosis and treatment with steroids is essential. Read More

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http://dx.doi.org/10.2174/1573402114666180903164900DOI Listing
September 2018
10 Reads

Endomyocardial Fibrosis With End-Stage Heart Failure as a Consequence of a Myeloproliferative Neoplasm With Hypereosinophilia.

Can J Cardiol 2018 Sep 5;34(9):1233.e13-1233.e15. Epub 2018 Jun 5.

Pathology Department, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Forensic Pathology, Central Branch, Instituto Nacional de Medicina Legal e Ciências Forenses, Coimbra, Portugal.

Hypereosinophilic syndrome is characterized by an overproduction of eosinophils that infiltrate and damage multiple organs. Cardiac dysfunction occurs frequently and is a main cause of morbidity and mortality. We describe the case of a middle-aged man diagnosed with a myeloproliferative neoplasm associated with hypereosinophilia and treated with imatinib. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.05.024DOI Listing
September 2018
13 Reads

Hypereosinophilic syndrome with cardiac involvement in a patient with multiple malignancies.

Med Ultrason 2018 Aug;20(3):399-400

"Carol Davila" University of Medicine and Pharmacy, Bucharest.

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http://dx.doi.org/10.11152/mu-1574DOI Listing
August 2018
2 Reads

[Vasculitides and eosinophilic pulmonary diseases].

Internist (Berl) 2018 09;59(9):898-910

Abt. für Rheumatologie, Immunologie und Rehabilitation, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Eosinophilic granulocytes form peripheral effector cells controlled by Th2 lymphocytes, which cause local cell, tissue, and functional disorders of infiltrated organs via the release of cytotoxic basic proteins and oxygen radicals. Diseases associated with eosinophilia include systemic and organ-related forms. The lungs are involved in eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome), acute and chronic eosinophilic pneumonia, as well as in an organ manifestation in hypereosinophilic syndrome and certain parasitic diseases. Read More

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http://link.springer.com/10.1007/s00108-018-0479-1
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http://dx.doi.org/10.1007/s00108-018-0479-1DOI Listing
September 2018
16 Reads

Speckle tracking and global longitudinal strain in endomyocardial infiltration during FIP1L1-PDGFRA chronic eosinophilic leukaemia.

Kardiol Pol 2018 ;76(8):1279

II Katedra i Oddział Kliniczny Kardiologii w Zabrzu Śląski Uniwersytet Medyczny.

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http://dx.doi.org/10.5603/KP.2018.0168DOI Listing
December 2018
5 Reads
0.520 Impact Factor

Pediatric Eosinophilic Esophagitis.

S D Med 2018 Aug;71(8):362-366

Sanford Children's Hospital, Sioux Falls, South Dakota.

Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal inflammatory disease that is becoming more widely recognized as a cause of feeding difficulties in infants and young children, as well as gastroesophageal reflux disease (GERD)-like symptoms, dysphagia, and food impaction in children and adolescents. The diagnosis of EoE is clinicopathologic, based on endoscopic, histologic, and clinical findings. Patients with suspected eosinophilic esophagitis require an endoscopy with biopsies. Read More

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August 2018
7 Reads

A multimodality work-up of patients with Hypereosinophilia.

Am J Hematol 2018 11 26;93(11):1337-1346. Epub 2018 Sep 26.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

The work-up of patients with hypereosinophilia (HE) is complex. Following the recently revised World Health Organization criteria, we retrospectively reviewed 125 patients who were referred to us to exclude a neoplastic cause of HE (2003-2016). The clinical laboratory work-up confirmed secondary HE in 25 (20%) patients; myeloid/lymphoid neoplasms with rearrangements of PDGFRA (n = 9) or PDGFRB (n = 2) (9%); HE associated with a well-defined myeloid neoplasm in 8 (6%); and abnormal bone marrow and/or molecular genetic abnormalities consistent with chronic eosinophilic leukemia (CEL), not otherwise specified (NOS) in 21 (17%) patients. Read More

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http://dx.doi.org/10.1002/ajh.25247DOI Listing
November 2018
14 Reads

Molecular Confirmation of Ascaris suum: Further Investigation into the Zoonotic Origin of Infection in an 8-Year-Old Boy with Loeffler Syndrome.

Vector Borne Zoonotic Dis 2018 11 7;18(11):638-640. Epub 2018 Aug 7.

1 Department of Pathobiological Sciences, Louisiana State University , Baton Rouge, Louisiana.

An 8-year-old male from south Louisiana was diagnosed with Loeffler syndrome of suspected Ascaris origin. Further investigation of the farm recovered larvated, infective Ascaris eggs from the soil in drains surrounding pens on the family's small hog farm. Molecular analysis of the recovered eggs, in conjunction with Ascaris-specific IgE, inadequate farm management and sanitation, and behavioral risk factors indicate the patient had an Ascaris suum soil-transmitted infection. Read More

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http://dx.doi.org/10.1089/vbz.2018.2306DOI Listing
November 2018
11 Reads

Intracardiac Thrombus in Leukemia: Role of Cardiac Magnetic Resonance Imaging in Eosinophilic Myocarditis.

CASE (Phila) 2018 Jun 14;2(3):114-117. Epub 2018 Apr 14.

East Carolina Heart Institute, Greenville, North Carolina.

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http://dx.doi.org/10.1016/j.case.2017.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058919PMC
June 2018
2 Reads

A very rare case of eosinophilic mastitis.

Int J Surg Case Rep 2018 20;49:251-254. Epub 2018 Jul 20.

Takahashi Breast and Gastroenterology Clinic, Yamazaki Seiren Bldg. 2F, 6-2-22, Uehonmachi, Tennoji-Ku, Osaka City, Osaka 543-0001, Japan. Electronic address:

Introduction: Eosinophilic mastitis caused by eosinophil infiltration of the mammary gland is very rare. To date, no report has been published on treating patients with this disorder using anti-allergic drugs. Steroids are commonly used in these cases, but have greater burden. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080636PMC
July 2018
2 Reads

Diagnosing persistent blood eosinophilia in asthma with single blood eosinophil or exhaled nitric oxide level.

Respir Med 2018 08 28;141:81-86. Epub 2018 Jun 28.

Department of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.

Background: Eosinophilic asthma is characterized by persistently elevated blood eosinophils, adult-onset asthma and corticosteroid resistance. For stratified medicine purposes one single measurement of blood eosinophils or exhaled nitric oxide (FeNO) is commonly used. The aim of this study was to investigate in patients with new-onset asthma whether persistent blood eosinophilia can be predicted with one single measurement of these biomarkers. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.06.025DOI Listing
August 2018
2 Reads

Conjunctival Eosinophilic Masses With Chronic Eosinophilic Pneumonia.

Cornea 2018 Oct;37(10):1326-1327

Department of Ophthalmology, National Institution of Hospital Organization Tokyo Medical Center, Tokyo, Japan.

Purpose: To report a case of ocular findings associated with chronic eosinophilic pneumonia (CEP).

Case: A 63-year-old man was referred to the National Institution of Hospital Organization Tokyo Medical Center with bilateral eyelid swelling due to giant papillomatous changes, each measuring approximately 10 mm in diameter with severe hyperemia on the tarsal conjunctiva. He was followed for CEP for 8 years and systemically treated with 6 mg oral prednisolone for an average of 5 years. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001659DOI Listing
October 2018
1 Read

Idiopathic hypereosinophilic syndrome with pulmonary hypertension.

Pulm Circ 2019 Jan-Mar;9(1):2045894018793999. Epub 2018 Jul 23.

1 Center of Cardiovascular Medicine, the First Hospital of Jilin University, Changchun, China.

Hypereosinophilic syndrome is a myeloproliferative disorder characterized by persistent eosinophilia with involvement of multiple organs. The occurrence of severe pulmonary hypertension (PH) in the setting of hypereosinophilic syndrome is very uncommon. A 43-year-old man with documented idiopathic hypereosinophlic syndrome presented to the hospital with symptoms of paroxysmal chest discomfort and progressive exertional dyspnea. Read More

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http://dx.doi.org/10.1177/2045894018793999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304700PMC
July 2018
3 Reads

A Test Utilization Approach to the Diagnostic Workup of Isolated Eosinophilia in Otherwise Morphologically Unremarkable Bone Marrow: A Single Institutional Experience.

Am J Clin Pathol 2018 Oct;150(5):421-431

Division of Hematopathology, Mayo Clinic, Rochester, MN.

Objectives: Determine ancillary test utilization for the workup of isolated eosinophilia in otherwise morphologically unremarkable bone marrow (BM).

Methods: We evaluated BM ancillary testing performed in cases with isolated eosinophilia and otherwise morphologically unremarkable BM. Cases with abnormal morphology (eg, dysplasia, basophilia) and/or findings suggestive of a disorder (eg, unexplained thromboses, lymphoma) are specifically excluded. Read More

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http://dx.doi.org/10.1093/ajcp/aqy064DOI Listing
October 2018
9 Reads

Loeffler endocarditis associated with a massive right intraventricular thrombus.

Intensive Care Med 2018 Jul 13. Epub 2018 Jul 13.

Department of Anesthesiology and Cardiac Surgery, Clinical University Hospital of Santiago de Compostela, Choupana sn, Santiago De Compostela, Spain.

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http://dx.doi.org/10.1007/s00134-018-5297-3DOI Listing
July 2018
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Endomyocardial fibrosis complicating primary hypereosinophilic syndrome.

Intensive Care Med 2018 Jul 13. Epub 2018 Jul 13.

Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Nice, 06200, Nice, France.

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http://dx.doi.org/10.1007/s00134-018-5300-zDOI Listing
July 2018
3 Reads

Gastrointestinal Manifestations of Hypereosinophilic Syndromes and Mast Cell Disorders: a Comprehensive Review.

Clin Rev Allergy Immunol 2018 Jul 12. Epub 2018 Jul 12.

Division of Allergy and Clinical Immunology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Hypereosinophilic syndrome and mastocytosis are relatively rare proliferative diseases encountered in the general population. However, allergists frequently consider these disorders in the differential of patients presenting with gastrointestinal, pulmonary, cutaneous, and allergic symptoms. Gastrointestinal symptoms are some of the most frequent and/or debilitating aspects of both disease states and in many cases lead to poor quality of life and functional limitation for the patient. Read More

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http://dx.doi.org/10.1007/s12016-018-8695-yDOI Listing

Dysphonia and dyspnea in idiopathic hypereosinophilic syndrome treated with Mepolizumab.

Respir Med Case Rep 2018 19;25:30-32. Epub 2018 May 19.

Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.

Hypereosinophilic syndrome (HES) is characterized by a persistently elevated eosinophil count associated with eosinophil-related end-organ damage and thromboembolic events, in the absence of an identifiable cause. We present a case of idiopathic HES with evidence of peripheral and tissue eosinophilia while on high dose prednisone, associated with muscle tension dysphonia, colitis, and jackhammer esophagus. The patient was treated with the interleukin-5 inhibitor, Mepolizumab, with resolution of symptoms including dyspnea, diarrhea and dysphonia. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038714PMC
May 2018
4 Reads

Gastrointestinal: A case of hypereosinophilic syndrome with esophageal involvement.

J Gastroenterol Hepatol 2018 Nov 10;33(11):1817. Epub 2018 Jul 10.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.

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http://doi.wiley.com/10.1111/jgh.14312
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http://dx.doi.org/10.1111/jgh.14312DOI Listing
November 2018
3 Reads

FIP1L1-PDGFRA fusion-negative hypereosinophilic syndrome with uncommon cardiac involvement responding to imatinib treatment: A case report.

Mol Clin Oncol 2018 Jul 21;9(1):35-39. Epub 2018 May 21.

Santa Terezinha University Hospital, Joaçaba, Santa Catarina 89600-000, Brazil.

Hypereosinophilic syndrome is a rare, chronic hematological disease characterized by a persistently elevated eosinophil count exceeding 1.5×10/l, following the exclusion of other potential etiologies. The systemic involvement of the disease causes tissue damage through eosinophil infiltration, and may affect various organs; cardiac complications are observed in 50-60% of cases, which are predominately attributed to endomyocardial fibrosis. Read More

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http://dx.doi.org/10.3892/mco.2018.1637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031893PMC
July 2018
2 Reads

Successful Medical Management of a Rare Loeffler Endocarditis Case.

Korean Circ J 2018 Jul;48(7):655-657

Department of Radiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

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http://dx.doi.org/10.4070/kcj.2017.0348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031717PMC

The Diagnostic Work-Up of Hypereosinophilia.

Authors:
Sa A Wang

Pathobiology 2019 29;86(1):39-52. Epub 2018 Jun 29.

Hypereosinophilia (HE) is defined as a persistent elevated eosinophil count of ≥1.5 × 109/L. HE can be one of the dominant manifestations of a hematopoietic myeloid neoplasm or secondary/reactive to an underlying medical condition. Read More

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http://dx.doi.org/10.1159/000489341DOI Listing
June 2018
23 Reads