251,760 results match your criteria Localized Fibrosing Disorders - Linear Scleroderma Morphea and Regional Fibrosis


Mitochondrial Respiration in Outer Retina Contributes to Light-Evoked Increase in Hydration In Vivo.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5957-5964

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan, United States.

Purpose: To test the hypothesis that mitochondrial respiration contributes to local changes in hydration involved in phototransduction-driven expansion of outer retina, as measured by structural responses on optical coherence tomography (OCT) and diffusion magnetic resonance imaging (MRI).

Methods: Oxygen consumption rate and mitochondrial reserve capacity of freshly isolated C57BL/6 and 129S6/SvEvTac mouse retina were measured using a Seahorse Extracellular Flux Analyzer. Light-stimulated outer retina layer water content was determined by proton density MRI, structure and thickness by ultrahigh-resolution OCT, and water mobility by diffusion MRI. Read More

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December 2018

Calreticulin regulates syncytialization through control of the synthesis and transportation of E-cadherin in BeWo cells.

Endocrinology 2018 Dec 14. Epub 2018 Dec 14.

Department of Obstetrics and Gynecology, Wakayama Medical University.

During placental development, mononuclear cytotrophoblasts differentiate and fuse to syncytiotrophoblasts (STB) to form syncytia, which secrete human chorionic gonadotropin (hCG). Decreased maternal perfusion of the placenta, which leads to placental dysfunction, induces changes in trophoblast syncytialization. Our previous study showed that calreticulin (CRT), a Ca2+-binding molecular chaperone found in the endoplasmic reticulum, is expressed in the human placenta and is involved in regulating extravillous trophoblast invasion, although its role in villous trophoblasts remains unclear. Read More

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December 2018

Microfluidics-based self-assembly of peptide-loaded microgels: Effect of three dimensional (3D) printed micromixer design.

J Colloid Interface Sci 2018 Dec 4;538:559-568. Epub 2018 Dec 4.

Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark; Department of Pharmacy, University of Uppsala, SE-75123 Uppsala, Sweden.

In an effort to contribute to research in scalable production systems for polymeric delivery systems loaded with antimicrobial peptides (AMPs), we here investigate effects of hydrodynamic flow conditions on microfluidic particle generation. For this purpose, rapid prototyping using 3D printing was applied to prepare micromixers with three different geometric designs, which were used to prepare Ca-cross-linked alginate microgels loaded with the AMP polymyxin B in a continuous process. Based on fluid dynamic simulations, the hydrodynamic flow patterns in the micromixers were designed to be either (i) turbulent with chaotic disruption, (ii) laminar with convective mixing, or (iii) convective with microvortex formation. Read More

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December 2018

Synthesis, photodynamic activities, and cytotoxicity of new water-soluble cationic gallium(III) and zinc(II) phthalocyanines.

J Inorg Biochem 2018 Dec 5;192:7-16. Epub 2018 Dec 5.

Department of Chemistry, Graduate School of Science and Engineering, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan. Electronic address:

The cationic Ga(III) and Zn(II) phthalocyanines carrying N-methyl-pyridinium groups at eight peripheral β-positionshave been synthesized. These complexes are highly soluble in dimethyl sulfoxide (DMSO) and moderately soluble in water and phosphate buffered saline (PBS); both Ga(III)Cl and Zn(II) complexes have shown no aggregation in water up to 1.2 × 10 and 1. Read More

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December 2018

The bovine herpesvirus major tegument protein, VP8, interacts with host HSP60 concomitant with deregulation of mitochondrial function.

Virus Res 2018 Dec 11. Epub 2018 Dec 11.

VIDO-InterVac, University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada; Vaccinology & Immunotherapeutics, University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada; Microbiology & Immunology, University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada. Electronic address:

The U47 gene product, VP8, is a major tegument protein of BoHV-1. While VP8 is not essential for virus replication in cell culture, a U47-deleted virus exhibits a smaller tegument structure and is avirulent in cattle. To obtain pure VP8 protein for structural analysis, we expressed a N-terminally truncated version of VP8 in Eschericia coli. Read More

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December 2018

MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy.

J Mol Cell Cardiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Molecular Physiology and Biophysics, Cardiovascular Research Institute of Vermont, University of Vermont, Burlington, VT, United States. Electronic address:

Rationale: Truncation mutations in the MYBPC3 gene, encoding for cardiac myosin-binding protein C (MyBP-C), are the leading cause of hypertrophic cardiomyopathy (HCM). Whole heart, fiber and molecular studies demonstrate that MyBP-C is a potent modulator of cardiac contractility, but how these mutations contribute to HCM is unresolved.

Objectives: To readdress whether MYBPC3 truncation mutations result in loss of MyBP-C content and/or the expression of truncated MyBP-C from the mutant allele and determine how these mutations effect myofilament sliding in human myocardium. Read More

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December 2018

Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.

ACS Nano 2018 Dec 14. Epub 2018 Dec 14.

Center for Systems Biology , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.

Prodrug strategies that facilitate localized and controlled activity of small-molecule therapeutics can reduce systemic exposure and improve pharmacokinetics, yet limitations in activation chemistry have made it difficult to assign tunable multifunctionality to prodrugs. Here, we present the design and application of a modular small-molecule caging strategy that couples bioorthogonal cleavage with a self-immolative linker and an aliphatic anchor. This strategy leverages recently discovered in vivo catalysis by a nanoencapsulated palladium compound (Pd-NP), which mediates alloxylcarbamate cleavage and triggers release of the activated drug. Read More

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December 2018

The serine protease testisin is present on the surface of capacitated stallion spermatozoa and interacts with key zona pellucida binding proteins.

Andrology 2018 Dec 13. Epub 2018 Dec 13.

Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.

Background And Objectives: Serine proteases are emerging as important players in the spermatozoon's acquisition of functional competence. This study aimed to characterize the serine protease testisin (PRSS21) in stallion spermatozoa, examining its surface expression, possible origins in the testis and epididymis, and changes in response to capacitation and acrosome reaction, as well as its capacity to form high molecular weight complexes and interact with other proteins.

Materials And Methods: The role of serine proteases in spontaneous capacitation and acrosome reaction of stallion spermatozoa was established using the serine protease inhibitor, AEBSF. Read More

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December 2018

Evaluation of the efficacy of granulocyte and monocyte adsorption apheresis on skin manifestation and joint symptoms of patients with pustulotic arthro-osteitis.

J Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

Pustulotic arthro-osteitis, occasionally complicated with palmoplantar pustulosis, affects patients' activities of daily living. Granulocyte and monocyte adsorption apheresis selectively removes activated granulocytes and monocytes by means of extracorporeal circulation. Although the efficacy of granulocyte and monocyte adsorption apheresis in the treatment of generalized pustular psoriasis has been proved, very few reports have assessed its efficacy in the treatment of palmoplantar pustulosis and pustulotic arthro-osteitis. Read More

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December 2018
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Hepatocyte Injury Induced by Contrast-Enhanced Diagnostic Ultrasound.

J Ultrasound Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.

Objectives: Contrast-enhanced diagnostic ultrasound (US) has a potential to induce localized biological effects. The potential for contrast-enhanced diagnostic US bioeffects in liver were researched, with guidance from a report by Yang et al (Ultrasonics 2012; 52:1065-1071).

Methods: Contact and standoff scanning was performed for 10 minutes with a diagnostic US phased array at 1. Read More

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December 2018

Pelvic magnetic resonance imaging parameters predict urinary incontinence after robot-assisted radical prostatectomy.

Low Urin Tract Symptoms 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Objective: Urinary incontinence (UI) is a major prostate cancer (PCa) treatment-related morbidity. It has been reported that post-prostatectomy UI is related to the width of the pelvic floor muscles (PFM) and the length of the urethra. However, the details of these anatomical parameters are unknown. Read More

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December 2018

A fast scheme to calculate electronic couplings between P3HT polymer units using diabatic orbitals for charge transfer dynamics simulations.

J Comput Chem 2019 Jan;40(2):532-542

Center of Nanophase Materials Sciences & Computational Sciences and Engineering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, 37831.

We propose a fast and accurate calculation method to compute the electronic couplings between molecular units in a thiophene-ring-based polymer chain mimicking a real organic semiconducting polymer, poly(3-hexylthiophene). Through a unit block diabatization scheme, the method employed minimal number of diabatic orbitals to compute the site energies and electronic couplings, which were validated by comparing with benchmark density functional theory calculations. In addition, by using the obtained electronic couplings, a quantum dynamics simulation was carried out to propagate a hole initially localized in a thiophene-ring unit of the polymer chain. Read More

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January 2019

Defining the complement C3 binding site and the antigenic region of Haemonchus contortus GAPDH.

Parasite Immunol 2018 Dec 12:e12611. Epub 2018 Dec 12.

Division of Biochemistry, ICAR-Indian Veterinary Research Institute, Izatnagar, India, 243122.

Haemonchus contortus is an economically important parasite that survives the host defense system by modulating the immune response. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is secreted by the parasite and the host responds by producing anti-enzyme antibodies. The enzyme inhibits complement cascade, an arm of the innate immunity, by binding to complement C3. Read More

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December 2018

Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells.

Aging Cell 2018 Dec 12:e12844. Epub 2018 Dec 12.

Bristol Medical School, University of Bristol, Bristol Royal Infirmary, Bristol, UK.

We previously reported pro-survival effects of Wnt3a and Wnt5a proteins in vascular smooth muscle cells (VSMCs). Wnt5a achieved this through induction of Wnt1-inducible signalling pathway protein-1 (WISP-1) consequent to β-catenin/CREB-dependent, TCF-independent, signalling. However, we found that as atherosclerosis advances, although Wnt5a protein was increased, WISP-1 was reduced. Read More

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December 2018

The synaptic and neuronal functions of the X-linked intellectual disability protein Interleukin-1 receptor accessory protein like 1 (IL1RAPL1).

Dev Neurobiol 2018 Dec 11. Epub 2018 Dec 11.

CNR Neuroscience Institute, Milan, Italy.

Since the first observation that described a patient with a mutation in IL1RAPL1 gene associated with intellectual disability in 1999, the function of IL1RAPL1 have been extensively studied by a number of laboratories. In this review, we summarize all the major data describing the synaptic and neuronal functions of IL1RAPL1 and recapitulate most of the genetic deletion identified in humans and associated to intellectual disability (ID) and autism spectrum disorders (ASD). All the data clearly demonstrate that IL1RAPL1 is a synaptic adhesion molecule localized at the postsynaptic membrane. Read More

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December 2018

Total Aqueous Synthesis of Au@Cu S Core-Shell Nanoparticles for In Vitro and In Vivo SERS/PA Imaging-Guided Photothermal Cancer Therapy.

Adv Healthc Mater 2018 Dec 7:e1801257. Epub 2018 Dec 7.

Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China.

Both accurate tumor navigation and nanostructures with high photothermal (PT) conversion efficiency are important but remain challenging to achieve in current biomedical applications. This study reports an anion exchange-based facile and green approach for synthesizing Au@Cu S core-shell nanoparticles (NPs) in an aqueous system. In addition to the PT effect of the suggested NPs, the surface-enhanced Raman scattering (SERS) is also significantly improved due to the tailored localized surface plasmon resonance coupling between the Au metal core and the Cu S semiconductor shell. Read More

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December 2018

Apelinergic system in the kidney: implications for diabetic kidney disease.

Physiol Rep 2018 Dec;6(23):e13939

Department of Medicine, Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

The bioactive peptides of the apelinergic system and its receptor APJ have been shown to play a protective role in experimental cardiovascular and diabetic kidney disease (DKD). Mechanisms of this renoprotective effect remain to be elucidated. In this study, we examined the localization of APJ within the normal kidney and its kidney expression in the db/db model of DKD. Read More

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December 2018
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Extremely high Q and unidirectional laser emission due to combination of the Kolmogorov-Arnold-Moser barrier and the chaotic sea in a dielectric microdisk.

Opt Lett 2018 Dec;43(24):6097-6100

Emission characteristics of an oval-shaped microcavity laser are studied. In experiments, modes localized on periodic orbits emit unidirectionally with a narrow in-plane divergence angle of about 12 deg. The origin of high directionality is elucidated by means of classical ray dynamics. Read More

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December 2018

Photoluminescence in hexagonal silicon carbide by direct femtosecond laser writing.

Opt Lett 2018 Dec;43(24):6077-6080

Direct femtosecond laser writing has been used to produce localized regions of photo-luminescent emission in 4H- and 6H-silicon carbide (SiC). Arrays of active color centers were fabricated by different pulse laser energies in the sites of square grids at various depths (from surface level to 10 μm below surface). We optically characterized the fabricated color centers using confocal imaging with 532 and 780 nm excitation, photo-luminescence spectroscopy, and lifetime decay at room temperature. Read More

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December 2018

Quadratic soliton combs in doubly resonant second-harmonic generation.

Opt Lett 2018 Dec;43(24):6033-6036

We report a theoretical investigation of quadratic frequency combs in a dispersive second-harmonic generation cavity system. We identify different dynamical regimes and demonstrate that the same system can exhibit both bright and dark localized cavity solitons in the absence of a temporal walk-off. Read More

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December 2018

Cavity-induced hybrid plasmon excitation for perfect infrared absorption.

Opt Lett 2018 Dec;43(24):6001-6004

Photonic microcavity coupling of a subwavelength hole-disk array, a two-element metal/dielectric composite structure with enhanced extraordinary transmission, leads to 100% coupling of incident light to the cavity system and subsequent absorption. This light-funneling process arises from the temporal and spatial coupling of the broadband localized surface plasmon resonance on the coupled hole-disk array and the photonic modes of the optical cavity, which induces spectral narrowing of the perfect absorption of light. A simple nanoimprint lithography-based large-area fabrication process paves the path towards practical implementation of plasmonic cavity-based devices and sensors. Read More

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December 2018
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Effect of puboprostatic ligament reconstruction on continence recovery after robot-assisted laparoscopic prostatectomy: our initial experience.

Minerva Urol Nefrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, Ospedale Policlinico e Nuovo Ospedale Civile S.Agostino Estense, University of Modena and Reggio Emilia, Modena, Italy.

Background: Prostate cancer represents a serious health problem worldwide. Radical prostatectomy is the gold standard for management of localized prostate cancer. Urinary incontinence is among the most common complications affecting RALP patients' post-operative quality of life. Read More

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December 2018

Obesity and inflammation.

Eur Cytokine Netw 2018 Sep;29(3):83-94

Department of Gastroenterology, Human Nutrition and Internal Medicine, Poznan University of Medical Sciences, Fredry 10, Poznan 61-701, Poland.

The prevalence of obesity has recently increased dramatically and has contributed to the increasing prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others. Accumulating evidence points to localized inflammation in adipose tissue, which, in turn, promotes systemic low-grade inflammation as a primary force contributing to the development of these pathologies. A better understanding of the underlying mechanisms behind obesity-induced adipose tissue inflammation is required to develop effective therapeutic or prophylactic strategies. Read More

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September 2018
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Ethyl violet-bovine serum albumin fluorescent protein nanovessels target to lysosomes and mitochondria.

Nanomedicine (Lond) 2018 Dec 14. Epub 2018 Dec 14.

State Key Laboratory of Supramolecular Structure & Materials & Institute of Theoretical Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China.

Aim: Organelles are essential in maintaining homeostasis of mammalian cells. Monitoring the morphology and dynamics of organelles is of significance in cell state determination and disease diagnosis.

Materials & Methods: We describe here a new material called ethyl violet-bovine serum albumin fluorescent protein nanovessel (EV-BSA FPN). Read More

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December 2018

Universal Dissipationless Dynamics in Gaussian Continuous-Variable Open Systems.

Phys Rev Lett 2018 Nov;121(22):220403

Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.

We investigate the universal dissipationless dynamics of Gaussian continuous-variable systems in the presence of a band-gapped bosonic environment. Our results show that environmental band gaps can induce localized modes, which give rise to the dissipationless dynamics where the system behaves as free oscillators instead of experiencing a full decay in the long-time limit. We present a complete characterization of localized modes and show the existence of the critical system-environment coupling. Read More

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November 2018

Vibrational Modes and Dynamic Heterogeneity in a Near-Equilibrium 2D Glass of Colloidal Kites.

Phys Rev Lett 2018 Nov;121(22):228003

Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People's Republic of China.

Using video microscopy and particle-tracking techniques developed for dense Brownian systems of polygons, we study the structure-dynamics relationship in a near-equilibrium 2D glass consisting of anisotropic Penrose kite-shaped colloids. Detailed vibrational properties of kite glasses, both translational and rotational, are obtained using covariance matrix techniques. Different from other colloidal glasses of spheres and ellipsoids, the vibrational modes of kite glasses at low frequencies show a strong translational character with spatially localized rotational modes and extended translational modes. Read More

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November 2018

An infant with primary pulmonary vein stenosis, associated with fatal occlusion of intraparenchymal small pulmonary veins.

J Cardiol Cases 2014 Jan 12;9(1):3-7. Epub 2013 Dec 12.

Japanese Research Institute of Pulmonary Vasculature, Japan.

Primary pulmonary vein stenosis (PVS) is rare within the pediatric population and its pathophysiology remains unclear, especially as to how the histopathology relates to its refractoriness to treatment. We report the case of a 4-month-old girl with primary PVS. The lesion in this patient was characterized by fatal obstruction of intraparenchymal small pulmonary veins, associated with localized stenosis at the four pulmonary veno-atrial junctions. Read More

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January 2014

Acute myocardial infarction caused by a floating thrombus in the ascending aorta: A role of CD34-positive endothelial cells.

J Cardiol Cases 2013 Aug 23;8(2):e88-e90. Epub 2013 May 23.

Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.

A 49-year-old woman was transferred to our hospital with acute-onset chest pain. Her electrocardiogram showed complete atrioventricular block and bradycardia with ST-segment elevation in the inferior leads, and she presented with cardiogenic shock. She was diagnosed with inferior acute myocardial infarction (AMI), and subsequent emergency cardiac catheterization was performed. Read More

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Transient semi-circumferential mid-ventricular ballooning: An atypical variant of takotsubo cardiomyopathy.

J Cardiol Cases 2016 Jul 1;14(1):21-23. Epub 2016 Apr 1.

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.

Although apical ballooning is the most common morphological type of takotsubo cardiomyopathy, variants have been reported. Several case reports have demonstrated focal takotsubo cardiomyopathy. Most cases had left ventricular wall motion abnormality in the anterolateral segment. Read More

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Skeletal evidence of probable treponemal infection in free-ranging African apes.

Primates 2000 Jul;41(3):275-290

Department of Anthropology, Colorado State University, 80523, Ft. Collins, Colorado, U. S. A.

The prevalence and patterning of inflammatory lesions of the skeleton were investigated in samples of chimpanzees (Pan troglodytes troglodytes) and gorillas (Gorilla gorilla gorilla) curated at the Powell-Cotton Museum, Birchington, UK. One hundred and two chimpanzees (42 adults and 60 subadults) and 126 gorillas (50 adults and 76 subadults) comprise the samples. Twenty per cent of chimpanzees and 14% of gorillas were affected with a disseminated inflammatory skeletal condition caused by infection. Read More

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Sources of Mercury Exposure to Children in Low- and Middle-Income Countries.

J Health Pollut 2015 Jun 2;5(8):33-51. Epub 2015 Jul 2.

Civil and Environmental Engineering, Department, U.C.L.A., Los Angeles, CA, U.S.A.

Background: Many children in low- and middle-income countries face enhanced risks of exposure to contaminants via the environment, parental occupation, and other routes. While mercury (Hg) is a global pollutant whose transport properties allow it to have an impact even in pristine areas, the presence of significant Hg sources in the developing world can cause localized effects that are more severe than those observed in other areas.

Objectives: This paper provides a narrative review of sources of Hg exposure to people in the developing world with a particular focus on children, and presents an overview of key aspects to this important issue. Read More

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Impact of low-dose prednisolone on refractory pitting edema manifesting remitting seronegative symmetrical synovitis with pitting edema syndrome.

J Cardiol Cases 2016 Oct 15;14(4):119-122. Epub 2016 Jul 15.

Department of Cardiology, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.

We encountered an elderly male patient who after cardiac surgery for mitral stenosis had refractory pitting edema in both legs involving painful leg joints after a 1-month history of waxing and waning arthralgia. His family doctor had prescribed a combination of diuretics, 40 mg furosemide and 25 mg spironolactone; however, pitting edema in his lower legs persisted. He was diagnosed with worsening of congestive heart failure because of a previous cardiac surgery and was transferred to our hospital. Read More

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October 2016

Development of Novel Free Radical Initiated Peptide Sequencing Reagent: Application to Identification and Characterization of Peptides by Mass Spectrometry.

J Am Soc Mass Spectrom 2018 Dec 13. Epub 2018 Dec 13.

Department of Chemistry and Biochemistry, Center for Quantitative Obesity Research, Montclair State University, 1 Normal Avenue, Montclair, NJ, 07043, USA.

By incorporating a high proton affinity moiety to the charge localized free radical-initiated peptide sequencing (CL-FRIPS) reagent, FRIPS-MS technique has extended the applicability to hydrophobic peptides and peptides without basic amino acid residues (lysine, arginine, and histidine). Herein, the CL-FRIPS reagent has three moieties: (1) pyridine acting as the basic site to locate the proton, (2) 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO, a stable free radical) acting as the free radical precursor to generate the nascent free radical in the gas phase, and (3) N-hydroxysuccinimide (NHS) activated carboxylic acid acting as the coupling site to derivatize the N-terminus of peptides. The CL-FRIPS reagent allows for the characterization of peptides by generating sequencing ions, enzymatic cleavage-like radical-induced side chain losses, and the loss of TEMPO simultaneously via one-step collisional activation. Read More

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December 2018

AuNP-peptide probe for caspase-3 detection in living cells by SERS.

Analyst 2018 Dec 14. Epub 2018 Dec 14.

State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, 300457 Tianjin, China. and Research Centre of Food Science and Human Health, School of Medicine, Nankai University, 300071 Tianjin, China.

Colloidal nanoparticles can be used as surface-enhanced Raman scattering (SERS) substrates because the very close spacing between particles existing in these colloidal systems is beneficial for the generation of extremely strong and highly spatially localized electric field enhancements. Herein, a caspase-3-specified peptide was used as a molecular cross-linker to engineer gold nanoparticle (AuNP) junctions in a controllable manner. The peptide was designed with a sequence of CCALNNPFFDVED (Cys-Cys-Ala-Leu-Asn-Asn-Pro-Phe-Phe-Asp-Val-Glu-Asp) or CCALNNKYDDVED (Cys-Cys-Ala-Leu-Asn-Asn-Lys-Tyr-Asp-Asp-Val-Glu-Asp), where the CALNN (Cys-Ala-Leu-Asn-Asn) fragment helps to stabilize AuNP suspension in aqueous media and the sequence of DVED (Asp-Glu-Val-Asp) can be cleaved by caspase-3. Read More

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December 2018
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Phase II Trial of Pure Hypofractionated Radiotherapy in the Treatment of Localized Carcinoma of the Prostate.

Cureus 2018 Oct 9;10(10):e3435. Epub 2018 Oct 9.

Radiation Oncology, Schulich School of Medicine & Dentistry - Western University, London, CAN.

Purpose To evaluate acute and late genitourinary (GU) and gastrointestinal (GI) toxicity and the biochemical control of pure hypofractionated radiotherapy (without acceleration) for the treatment of prostate cancer. Methods and materials This phase II prospective trial evaluated low-risk and intermediate-risk prostate cancer patients who received hypofractionated radiotherapy. Fifty-three patients with low-risk prostate cancer received 50 Gy in 15 fractions, 156 patients with intermediate-risk prostate cancer received 60 Gy in 20 fractions over eight weeks. Read More

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October 2018

An Uncommon Presentation of Leiomyoma Cecum as a Subcutaneous Abscess of the Right Flank.

Cureus 2018 Oct 9;10(10):e3432. Epub 2018 Oct 9.

Otolaryngology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Cecal leiomyomas are rare benign tumors of smooth muscle arising from the colonic muscularis mucosa or muscularis propria. They are usually asymptomatic in nature and, if symptomatic, may present as pain in the abdomen, intestinal obstruction, or bleeding. In some cases, leiomyoma can cause free perforation leading to peritonitis. Read More

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October 2018
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Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma.

Oncoimmunology 2019 11;8(1):e1507669. Epub 2018 Oct 11.

Department of Immunology, Lerner Research Institute, Cleveland, OH, USA.

Nearly half of melanoma patients develop brain metastases during the course of their disease. Despite advances in both localized radiation and systemic immunotherapy, brain metastases remain difficult to treat, with most patients surviving less than 5 months from the time of diagnosis. While both treatment regimens have individually shown considerable promise in treating metastatic melanoma, there is interest in combining these strategies to take advantage of potential synergy. Read More

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October 2018
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Neoadjuvant sipuleucel-T induces both Th1 activation and immune regulation in localized prostate cancer.

Oncoimmunology 2019 1;8(1):e1486953. Epub 2018 Oct 1.

Division of Hematology and Oncology, University of California, San Francisco, CA, USA.

Sipuleucel-T is the only FDA-approved immunotherapy for metastatic castration-resistant prostate cancer. The mechanism by which this treatment improves survival is not fully understood. We have previously shown that this treatment can induce the recruitment of CD4 and CD8 T cells to the tumor microenvironment. Read More

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October 2018

Genetic associations of T cell cancer immune response with tumor aggressiveness in localized prostate cancer patients and disease reclassification in an active surveillance cohort.

Oncoimmunology 2019 29;8(1):e1483303. Epub 2018 Oct 29.

Departments of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Determining prostate cancer (PCa) aggressiveness and reclassification are critical events during the treatment of localized disease and for patients undergoing active surveillance (AS). Since T cells play major roles in cancer surveillance and elimination, we aimed to identify genetic biomarkers related to T cell cancer immune response which are predictive of aggressiveness and reclassification risks in localized PCa. The genotypes of 3,586 single nucleotide polymorphisms (SNPs) from T cell cancer immune response pathways were analyzed in 1762 patients with localized disease and 393 who elected AS. Read More

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October 2018

Shank-associated RH domain-interacting protein expression is upregulated in entodermal and mesodermal cancer or downregulated in ectodermal malignancy.

Oncol Lett 2018 Dec 27;16(6):7180-7188. Epub 2018 Sep 27.

Department of Dermatology, Cosmetology and Venereology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518101, P.R. China.

Shank-associated RH domain-interacting protein (SHARPIN) is a type of linear ubiquitin chain-associated protein, which serves an important role in cell proliferation, apoptosis, organ development, immune and inflammatory reaction, initiation and development of malignant tumors. To evaluate SHARPIN expression in multiple malignant tumors derived from different germ layers, 14 types of cancer and their corresponding normal tissues were examined. Immunohistochemistry was performed to semi-quantify SHARPIN expression in multiple malignant tumors, and immunofluorescence was performed to evaluate the subcellular localization of SHARPIN in various malignant tumors. Read More

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December 2018

Racial disparities in the survival time of patients with hepatocellular carcinoma and intrahepatic cholangiocarcinoma between Chinese patients and patients of other racial groups: A population-based study from 2004 to 2013.

Oncol Lett 2018 Dec 5;16(6):7102-7116. Epub 2018 Oct 5.

Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

The aim of the present study was to investigate the racial disparities in the presentation, treatment and survival time of patients with hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICC) between Chinese and other racial groups from the Surveillance, Epidemiology, and End Results (SEER) database between January 1st 2004, and December 31st 2013. Key covariates, including clinical presentation, treatment and survival time, were recorded and compared, demonstrating the racial differences. Kaplan-Meier analysis and Cox regression models were performed to identify these disparities in survival time. Read More

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December 2018

Chromosome instability in neuroblastoma.

Oncol Lett 2018 Dec 3;16(6):6887-6894. Epub 2018 Oct 3.

Neuroblastoma Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, I-35127 Padua, Italy.

Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of <40% at 5 years from diagnosis. HR patients with unfavorable prognosis exhibit several structural copy number variations (CNVs), whereas localized tumors belonging to patients in the low- and intermediate-risk classes, have favorable outcomes and display several numerical CNVs. Read More

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December 2018

Injectable Biomimetic Hydrogels as Tools for Efficient T Cell Expansion and Delivery.

Front Immunol 2018 28;9:2798. Epub 2018 Nov 28.

Department of Tumor Immunology, Oncode Institute, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

Biomaterial-based scaffolds are promising tools for controlled immunomodulation. They can be applied as three dimensional (3D) culture systems , whereas they may be used to dictate cellular localization and exert spatiotemporal control over cues presented to the immune system. As such, scaffolds can be exploited to enhance the efficacy of cancer immunotherapies such as adoptive T cell transfer, in which localization and persistence of tumor-specific T cells dictates treatment outcome. Read More

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November 2018

Estimating Recent Local Impacts of Sea-Level Rise on Current Real-Estate Losses: A Housing Market Case Study in Miami-Dade, Florida.

Popul Res Policy Rev 2018 26;37(6):871-895. Epub 2018 Jun 26.

2Environmental Health Sciences, Columbia University's Mailman School of Public Health, New York, NY USA.

Sea-Level Rise (SLR) Projections from the National Oceanic and Atmospheric Administration (NOAA) and the U.S. Army Corp of Engineers (USACE) indicate increasing, and imminent, risk to coastal communities from tidal flooding and hurricane storm surge. Read More

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Clinico-pathological features of the intradiaphragmatic bronchogenic cysts: report of a case and review of the literature.

Pathologica 2018 Sep;110(2):116-120

Department of Pathology, University General Hospital of Catalonia, Sant Cugat del Vallès, Barcelona, Spain.

Bronchogenic cysts represent congenital malformations deriving from an abnormal development of the primitive foregut during embryogenesis. These lesions are rarely found and they are most frequently localized in the mediastinum, or in lung parenchyma. Intramuscular localization is extremely rare, especially within the diaphragm. Read More

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September 2018

RSL Class Ⅱ Transcription Factors Guide the Nuclear Localization of RHL1 to Regulate Root Hair Development.

Plant Physiol 2018 Dec 13. Epub 2018 Dec 13.

Kyung Hee University CITY: Yongin STATE: Gyeonggi-do POSTAL_CODE: 17104 Korea (South), Republic Of

Root hairs are important for absorption of nutrients and water from the rhizosphere. The ROOT HAIR DEFECTIVE-SIX LIKE (RSL) Class Ⅱ family of transcription factors is expressed preferentially in root hairs and has a conserved role in root hair development in land plants. We functionally characterized the seven members of the RSL Class II subfamily in the rice (Oryza sativa) genome. Read More

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December 2018

Much Ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localized oedema.

Clin Sci (Lond) 2018 Dec 13;132(24):2609-2613. Epub 2018 Dec 13.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.

Hypertonic Na accumulation in peripheral tissues is a recently described phenomenon: it has been associated with ageing, hypertension, diabetes, chronic kidney disease and heart failure, but its clinical meaning has yet to be determined. This concept conflicts with the classic physiological paradigm of constant balance between salt intake and excretion, and its water-independent nature is still a matter of debate.We developed a theoretical model explaining changes in the chemical composition of tissues as a function of extracellular volume fraction and excess extracellular fluid, i. Read More

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December 2018
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Revealing hidden spin-momentum locking in a high-temperature cuprate superconductor.

Science 2018 Dec 13;362(6420):1271-1275. Epub 2018 Dec 13.

Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Cuprate superconductors have long been thought of as having strong electronic correlations but negligible spin-orbit coupling. Using spin- and angle-resolved photoemission spectroscopy, we discovered that one of the most studied cuprate superconductors, Bi2212, has a nontrivial spin texture with a spin-momentum locking that circles the Brillouin zone center and a spin-layer locking that allows states of opposite spin to be localized in different parts of the unit cell. Our findings pose challenges for the vast majority of models of cuprates, such as the Hubbard model and its variants, where spin-orbit interaction has been mostly neglected, and open the intriguing question of how the high-temperature superconducting state emerges in the presence of this nontrivial spin texture. Read More

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December 2018
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Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder.

Science 2018 Dec;362(6420)

Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.

Whole-genome sequencing (WGS) has facilitated the first genome-wide evaluations of the contribution of de novo noncoding mutations to complex disorders. Using WGS, we identified 255,106 de novo mutations among sample genomes from members of 1902 quartet families in which one child, but not a sibling or their parents, was affected by autism spectrum disorder (ASD). In contrast to coding mutations, no noncoding functional annotation category, analyzed in isolation, was significantly associated with ASD. Read More

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December 2018
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Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes.

Malar J 2018 Dec 13;17(1):466. Epub 2018 Dec 13.

Division of Molecular Parasitology, Proteo-Science Center, Ehime University, Toon, Ehime, 791-0295, Japan.

Background: For the success of the malaria control and eradication programme it is essential to reduce parasite transmission by mosquito vectors. In the midguts of mosquitoes fed with parasite-infected blood, sexual-stage parasites fertilize to develop into motile ookinetes that traverse midgut epithelial cells and reside adjacent the basal lamina. Therefore, the ookinete is a promising target of transmission-blocking vaccines to break the parasite lifecycle in mosquito vectors. Read More

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December 2018