10,927 results match your criteria Localization-related Epilepsies on EEG

fMRI-Based Effective Connectivity in Surgical Remediable Epilepsies: A Pilot Study.

Brain Topogr 2021 Jun 21. Epub 2021 Jun 21.

Neurology Unit, OCB Hospital, Azienda Ospedaliero-Universitaria of Modena, Via Giardini 1355, 41100, Modena, Italy.

Simultaneous EEG-fMRI can contribute to identify the epileptogenic zone (EZ) in focal epilepsies. However, fMRI maps related to Interictal Epileptiform Discharges (IED) commonly show multiple regions of signal change rather than focal ones. Dynamic causal modeling (DCM) can estimate effective connectivity, i. Read More

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Meningioangiomatosis: an uncommon cause of focal epilepsy with characteristic neuroimaging and neuropathology.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Neuropathology, Greater Manchester Neurosciences Centre, Salford, UK.

A 3-year-old boy presented with acute onset of prolonged right sided focal seizures with secondary generalisation. The investigation findings were suggestive of a neoplastic process more than an inflammatory process. Decision to perform brain biopsy from the lesion to establish the precise nature of lesion was undertaken. Read More

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The attention networks in benign epilepsy with centrotemporal spikes: A long-term follow-up study.

J Clin Neurosci 2021 Jun 29;88:22-27. Epub 2021 Mar 29.

Department of Neurology, Anhui Provincial Children's Hospital, Hefei 230051, PR China. Electronic address:

Purpose: To evaluate the long-term prognosis of attention deficit in children with newly diagnosed benign childhood epilepsy with centrotemporal spikes (BECTS).

Methods: Attention network test (ANT) was performed over a period of 7 years on 42 patients who were newly diagnosed with BECTS, in the Department of Neurology of Anhui Provincial Children's Hospital.

Results: In the patients' group, the accuracy of ANT was lower (P = 0. Read More

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Palinacousis: an eloquent symptom of temporal lobe lesion.

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

Division of Neurosurgery, University of Montreal, Montreal, Quebec, Canada

A 24-year-old woman was referred to us for an intracranial haemorrhage in the left temporal lobe caused by a ruptured cavernous malformation; the bleeding extended over the left Heschl's gyrus and Wernicke area. On admission, the patient had global aphasia. A few days later, she spontaneously improved but remained with mild residual comprehensive dysphasia. Read More

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The effect of injection time on rates of epileptogenic zone localization using SISCOM and STATISCOM.

Epilepsy Behav 2021 05 10;118:107945. Epub 2021 Apr 10.

Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia; Department of Medicine and Radiology, University of Melbourne, Parkville, VIC, Australia; Department of Neurosciences, Monash University, Melbourne, VIC, Australia; Department of Neurology, Alfred Hospital, Melbourne, VIC, Australia. Electronic address:

Background: The identification of hyperperfusion on ictal single-photon emission computed tomography (SPECT) scan is a technique for the localization of the epileptogenic zone (EZ) in patients with focal epilepsy undergoing presurgical evaluation. The accuracy of this technique has been improved by subtraction from an interictal image and coregistration with magnetic resonance imaging (MRI) (subtraction ictal SPECT coregistered to MRI (SISCOM)), and subsequently by the development of Statistical Ictal SPECT Co-registered to MRI (STATISCOM) which is reported to further improve localization accuracy by statistically accounting for random variation between images. However, the use of ictal SPECT is limited by the necessity for rapid injection of the radiotracer. Read More

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Focal cortical dysplasia: an update on diagnosis and treatment.

Expert Rev Neurother 2021 Apr 25:1-12. Epub 2021 Apr 25.

Neuroscience Department, Children's Hospital Meyer-University of Florence, Florence, Italy.

Introduction: Focal cortical dysplasias (FCDs) represent the most common etiology in pediatric drug-resistant focal epilepsies undergoing surgical treatment. The localization, extent and histopathological features of FCDs are considerably variable. Somatic mosaic mutations of genes that encode proteins in the PI3K-AKTmTOR pathway, which also includes the tuberous sclerosis associated genes and , have been implicated in FCD type II in a substantial subset of patients. Read More

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Electro-clinical features in epileptic children with chromosome 15q duplication syndrome.

Clin Neurophysiol 2021 May 10;132(5):1126-1137. Epub 2021 Mar 10.

Department of Clinical Neurophysiology, Necker-Enfants-Malades Hospital, Assistance Publique -Hôpitaux de Paris, Paris, France; Université de Paris, Paris, France.

Objective: We aimed to describe epilepsy and EEG patterns related to vigilance states and age, in chromosome15-long-arm-duplication-syndrome (dup15q) children with epilepsy, in both duplication types: interstitial (intdup15) and isodicentric (idic15).

Methods: Clinical data and 70 EEGs of 12 patients (5 intdup15, 7 idic15), followed from 4.5 m. Read More

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New Ethical and Clinical Challenges in "Closed-Loop" Neuromodulation.

Neurology 2021 04 16;96(17):799-804. Epub 2021 Mar 16.

From the Department of Neurology and Weill Institute for Neurosciences, University of California, CA.

Neurostimulation provides a new dimension in the treatment of neurologic disorders. For patients with drug-resistant epilepsy, the Responsive Neurostimulation (RNS) System (NeuroPace, Inc.) provides treatment of seizures with a closed-loop device that continuously records brain activity and provides stimulation designed to reduce seizure frequency over time. Read More

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Incidence and Prevalence of Drug-Resistant Epilepsy: A Systematic Review and Meta-analysis.

Neurology 2021 04 15;96(17):805-817. Epub 2021 Mar 15.

From the Research Centre of the Centre Hospitalier de l'Université de Montréal (CRCHUM) (B.S., M.-A.P., A.V.C., J.C., B.R., M.R.K.); Department of Neurosciences (B.S., M.-A.P., A.V.C., J.C., B.R., M.R.K.), Université de Montréal, Quebec; Schulich Library of Physical Sciences (G.G.), Life Sciences, and Engineering, McGill University, Montreal, Quebec, Canada; Department of Psychosomatic Medicine and Psychotherapy (P.R.B.), University Medical Center Freiburg, Germany; Department of Neurology (C.-S.K., N.J.), Icahn School of Medicine at Mount Sinai, New York; Department of Clinical Neurosciences and Hotchkiss Brain Institute (N.J., C.B.J.), University of Calgary, Alberta; and School of Public Health of the Université de Montréal (M.R.K.), Quebec, Canada.

Objective: To evaluate the incidence and prevalence of drug-resistant epilepsy (DRE) as well as its predictors and correlates, we conducted a systematic review and meta-analysis of observational studies.

Methods: Our protocol was registered with PROSPERO, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Meta-analysis of Observational Studies in Epidemiology reporting standards were followed. We searched MEDLINE, Embase, and Web of Science. Read More

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Ambulatory EEG Usefulness in Epilepsy Management.

J Clin Neurophysiol 2021 Mar;38(2):101-111

Department of Neurology, Mayo Clinic, Jacksonville, Florida, U.S.A.

Summary: Long-term video-EEG monitoring has been the gold standard for diagnosis of epileptic and nonepileptic events. Medication changes, safety, and a lack of recording EEG in one's habitual environment may interfere with diagnostic representation and subsequently affect management. Some spells defy standard EEG because of ultradian and circadian times of occurrence, manifest nocturnal expression of epileptiform activity, and require classification for clarifying diagnostic input to identify optimal treatment. Read More

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A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy.

Nat Commun 2021 03 3;12(1):1423. Epub 2021 Mar 3.

Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USA.

In the mammalian hippocampus, adult-born granule cells (abGCs) contribute to the function of the dentate gyrus (DG). Disruption of the DG circuitry causes spontaneous recurrent seizures (SRS), which can lead to epilepsy. Although abGCs contribute to local inhibitory feedback circuitry, whether they are involved in epileptogenesis remains elusive. Read More

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[Frontal lobe epilepsy or a psychogenic disorder? The importance of taking a good patient history].

Ned Tijdschr Geneeskd 2021 02 18;164. Epub 2021 Feb 18.

Maastricht UMC+, afd. Neurologie, Maastricht.

Background: Frontal lobe epilepsy (FE) is a diagnosis which can be easily missed due to the variety in symptoms. The symptoms depend on the location of the epileptical activity in the frontal lobe.

Case Description: A 48-year-old man of Moroccan descent is diagnosed with frontal epilepsy, but this diagnosis is rejected based on the 24-hours EEG. Read More

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February 2021

Recognition of interictal and ictal discharges on EEG. Focal vs generalized epilepsy.

Epilepsy Behav 2021 04 25;117:107830. Epub 2021 Feb 25.

Epilepsy, Detroit Medical Center, Wayne State University, United States.

Introduction: The differentiation between focal and generalized epilepsies based on clinical and electroencephalographic features is difficult and sometimes confusing.

Objective: To review the EEG findings in patients with focal epilepsy.

Methods: An extensive literature review was done. Read More

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[Go-induced epilepsy treatment with levetiracetam successfully prevented seizures].

Rinsho Shinkeigaku 2021 Mar 23;61(3):204-206. Epub 2021 Feb 23.

Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital.

There are only a few reports on Go-induced epilepsy. We hereby report a case of Go-induced epilepsy and its ictal electroencephalography (EEG) findings, and treatment. A 71-year-old man reported to our hospital for seizures that lasted for several minutes after he had played Go for approximately an hour. Read More

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In silico model reveals the key role of GABA in KCNT1-epilepsy in infancy with migrating focal seizures.

Epilepsia 2021 Mar 22;62(3):683-697. Epub 2021 Feb 22.

LTSI-U1099, Université de Rennes 1, INSERM, Rennes, France.

Objective: This study was undertaken to investigate how gain of function (GOF) of slack channel due to a KCNT1 pathogenic variant induces abnormal neuronal cortical network activity and generates specific electroencephalographic (EEG) patterns of epilepsy in infancy with migrating focal seizures.

Methods: We used detailed microscopic computational models of neurons to explore the impact of GOF of slack channel (explicitly coded) on each subtype of neurons and on a cortical micronetwork. Then, we adapted a thalamocortical macroscopic model considering results obtained in detailed models and immature properties related to epileptic brain in infancy. Read More

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Temporal lobe dysfunction in late-onset epilepsy of unknown origin.

Epilepsy Behav 2021 04 18;117:107839. Epub 2021 Feb 18.

Department of Neurology, ASST S. Gerardo Hospital, University of Milano - Bicocca, Monza, Italy; Milan Center for Neuroscience (NeuroMI), Italy.

Objective: Epilepsy with onset in the adulthood is an increasing health problem, due to the progressive aging of the worldwide population. Whether the causes remain undetermined, the disease is defined as Late-Onset Epilepsy of Unknown origin (LOEU). The aim of this study was to evaluate the semiological, electroencephalographic, metabolic, and neuropsychological features of LOEU. Read More

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Clinical significance of bilateral epileptiform discharges in temporal lobe epilepsy.

Acta Neurol Scand 2021 Jun 16;143(6):608-613. Epub 2021 Feb 16.

Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: The aim of the current study was to investigate the rate and clinical significance of bitemporal interictal epileptiform discharges (IEDs) in a large cohort of patients with temporal lobe epilepsy (TLE).

Methods: The data used in this study were collected at the Epilepsy Care Unit, Namazi Hospital, Shiraz University of Medical sciences, Shiraz, Iran, from 2008 to 2020. Inclusion criteria were a confirmed diagnosis of TLE based on the clinical grounds (history and the described seizure semiology) and a 2-hour interictal video-electroencephalography (EEG) monitoring. Read More

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Psychogenic nonepileptic seizures: The effect of accurate diagnosis on cognition.

Epilepsy Behav 2021 04 12;117:107766. Epub 2021 Feb 12.

Department of Neurosciences, Hospital Germans Trias i Pujol, C/Canyet s/n, 08916 Badalona, Spain.

Objective: Much remains to be elucidated about the cognitive profile of patients with psychogenic nonepileptic seizures (PNES) and about how this changes over time and compares to that of patients with epilepsy. The aim of this study was to study the neuropsychological profile of patients with PNES and an age-matched group of patients with temporal lobe epilepsy (TLE) during admission to a video electroencephalography monitoring unit (VEMU) and 1 year after discharge.

Methods: Patients diagnosed with PNES or TLE at a VEMU were prospectively recruited. Read More

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Seizure focus in the frontal interhemispheric fissure leads to ipsilateral isolated eye deviation.

Epilepsy Behav 2021 03 6;116:107772. Epub 2021 Feb 6.

Department of Epilepsy and Neurosurgery, Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Hamamatsu, Shizuoka 4308558, Japan. Electronic address:

Objective: Few studies have examined the localization of seizures presenting with ictal eye deviation (ED) in the absence of other motor symptoms. We aimed to investigate differences in the localization of the ictal onset zone (IOZ) between patients with isolated ED and those with ED plus head turning (HT) during focal seizures.

Methods: We reviewed intracranial video-EEG data for 931 seizures in 80 patients with focal onset epilepsy in whom the IOZ could be confirmed. Read More

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Effects of sulthiame on seizure frequency and EEG in children with electrical status epilepticus during slow sleep.

Epilepsy Behav 2021 03 4;116:107793. Epub 2021 Feb 4.

Department of Pediatric Neurology, Istanbul Medipol University Faculty of Medicine, Istanbul, Turkey.

Objective: It is argued that early and adequate treatment of electrical status epilepticus in sleep (ESES) is essential to preserve cognitive functions and possibly recovering lost skills. Although antiepileptic drugs (AEDs) are effective in ESES, there is not much experience in the use of sulthiame. In this study, we aimed to examine the efficiency and tolerability of sulthiame in ESES. Read More

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A Young man with Peri-ictal water drinking.

Ghalib M Alanazi

Neurosciences (Riyadh) 2021 Jan;26(1):85-88

From the Department of Pediatric Neurology, Epilepsy Monitoring Unit, National Neuroscience Institute, King Fahad Medical City, Riyadh, Kingdom Of Saudi Arabia.

Neuro-vegetative features have been linked to epilepsy arising from the temporal lobe, which can be seen during ictal events and play an important role in determining the focal side of the lesion. Among the rare known features is peri-ictal water drinking (PIWD). Here, we present the case of a 31-year-old male with refractory temporal epilepsy, having episodes of PIWD. Read More

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January 2021

Implicit cognitive flexibility in self-limited focal epilepsy of childhood: An HD-EEG study.

Epilepsy Behav 2021 03 22;116:107747. Epub 2021 Jan 22.

Department of General Psychology, University of Padova, Italy; Padova Neuroscience Center (PNC), University of Padova, Italy.

Self-limited focal epilepsy of childhood (SFEC) is often related to mild impairments in several neuropsychological domains, including cognitive flexibility, which is generally considered a process requiring volition and attention. However, recent evidence showed that it can be implicitly adjusted exploiting simple 'stimulus-response' associations as for example, the probability of the stimulus occurrence. Here, we evaluated the capability to implicitly extract environmental patterns of regularities and use them to flexibly adjust proactive control motor control. Read More

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Absolute spike frequency and different comorbidities in temporal lobe epilepsy.

Epilepsy Behav 2021 03 23;116:107730. Epub 2021 Jan 23.

Preventive Medicine Service, Army Health Unit, Santiago, Chile. Electronic address:

Objective: The objective of this study was to examine if the absolute number of interictal epileptiform discharges (IED) is related to the presence of different comorbidities and refractivity in patients with temporal lobe epilepsy.

Methods: Analysis with scalp EEG of the IED of 30 patients with temporal epilepsy. The analysis was performed in three selected periods of the record during N2-N3 sleep. Read More

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Ictal injury: Epilepsy vs. functional (psychogenic) seizures.

Epilepsy Behav 2021 03 21;116:107727. Epub 2021 Jan 21.

Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: The aim of the current study was to compare the risk and also the types of ictal injuries in three groups of people with seizures [i.e., IGE vs. Read More

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Quantitative FDG PET asymmetry features predict long-term seizure recurrence in refractory epilepsy.

Epilepsy Behav 2021 03 21;116:107714. Epub 2021 Jan 21.

Center for Neuroengineering and Therapeutics, University of Pennsylvania, 240 Skirkanich Hall, 210 S 33rd St, Philadelphia, PA 19104, United States; Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce St, 3 West Gates Bldg, Philadelphia, PA 19104, United States. Electronic address:

Objective: Fluorodeoxyglucose-positron emission tomography (FDG-PET) is an established, independent, strong predictor of surgical outcome in refractory epilepsy. In this study, we explored the added value of quantitative [F]FDG-PET features combined with clinical variables, including electroencephalography (EEG), [F]FDG-PET, and magnetic resonance imaging (MRI) qualitative interpretations, to predict long-term seizure recurrence (mean post-op follow-up of 5.85 ± 3. Read More

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Focal Sleep Spindle Deficits Reveal Focal Thalamocortical Dysfunction and Predict Cognitive Deficits in Sleep Activated Developmental Epilepsy.

J Neurosci 2021 02 19;41(8):1816-1829. Epub 2021 Jan 19.

Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114

Childhood epilepsy with centrotemporal spikes (CECTS) is the most common focal epilepsy syndrome, yet the cause of this disease remains unknown. Now recognized as a mild epileptic encephalopathy, children exhibit sleep-activated focal epileptiform discharges and cognitive difficulties during the active phase of the disease. The association between the abnormal electrophysiology and sleep suggests disruption to thalamocortical circuits. Read More

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February 2021

Lateralization value of peri-ictal headache in drug-resistant focal epilepsy.

Epilepsy Behav 2021 03 18;116:107712. Epub 2021 Jan 18.

Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. Electronic address:

Objective: To examine the lateralizing value of unilateral peri-ictal and interictal headaches in patients with drug-resistant focal epilepsy (DRFE).

Methods: Four-hundred consecutive patients undergoing presurgical evaluation for DRFE were interviewed. Patients with headache were broadly divided into two groups: peri-ictal and interictal headache. Read More

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Spermatorrhea in a Chinese patient with temporal lobe epilepsy: a case report.

J Int Med Res 2021 Jan;49(1):300060520982814

Department of Neurology and Research Center of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure. Sexual dysfunction has been reported in patients with seizure, which mostly manifests as erectile dysfunction and premature ejaculation in men. In this study, we report the case of a 65-year-old Chinese man with frequent spermatorrhea. Read More

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January 2021

Role of the Nucleus Basalis as a Key Network Node in Temporal Lobe Epilepsy.

Neurology 2021 03 13;96(9):e1334-e1346. Epub 2021 Jan 13.

From the Departments of Biomedical Engineering (H.F.J.G., G.W.J., P.E.K., C.C., V.L.M., M.R., D.J.E.) and Electrical Engineering and Computer Science (C.C., V.L.M., M.R., D.J.E.), Vanderbilt University; Departments of Neurological Surgery (S.N., K.E.W., P.E.K., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), and Neurology (K.F.H.) and Vanderbilt University Institute of Imaging Science (H.F.J.G., S.N., G.W.J., K.E.W., C.C., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, TN; and Department of Psychology (M.R.), Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.

Objective: To determine whether the nucleus basalis of Meynert (NBM) may be a key network structure of altered functional connectivity in temporal lobe epilepsy (TLE), we examined fMRI with network-based analyses.

Methods: We acquired resting-state fMRI in 40 adults with TLE and 40 matched healthy control participants. We calculated functional connectivity of NBM and used multiple complementary network-based analyses to explore the importance of NBM in TLE networks without biasing our results by our approach. Read More

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