763 results match your criteria Localization-related Epilepsies on EEG
Epilepsia Open 2018 Dec 16;3(4):503-510. Epub 2018 Oct 16.
Epilepsy Division Department of Neurology University of Rochester Rochester New York U.S.A.
Objective: Despite the heavy burden of epilepsy in Sub-Saharan Africa, there remains a relative paucity of neurophysiology services and limited published data on electroencephalography (EEG) features among African children. The aim of this study was to describe clinical characteristics, EEG findings, and antiepileptic drug (AED) use among children referred for EEG to the University Teaching Hospital in Zambia.
Methods: EEG referrals and reports from 2013-2015 were reviewed. Read More
Cell Physiol Biochem 2018 28;51(3):1399-1409. Epub 2018 Nov 28.
Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao,
Background/aims: Temporal lobe epilepsy (TLE) is the most common form of adult localization-related epilepsy that is accompanied by progressive etiopathology and high incidences of drug resistance. Circular RNAs (circRNAs) play important roles in fine-tuning gene expression, however, the expression profile and clinical significance of circRNAs in TLE remains unknown.
Methods: Circular RNA microarray was conducted to identify TLE-related circRNAs. Read More
World Neurosurg 2018 Nov 24. Epub 2018 Nov 24.
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226; Department of Neurosurgery, Children's Hospital of Wisconsin, Milwaukee, WI 53226. Electronic address:
Background: Hypothalamic hamartomas (HHs) are non-neoplastic congenital malformations associated with refractory epilepsy and behavioral disorders. Improvement in behavioral functioning following resection of HHs has been reported. Stereotactic laser ablation (SLA), a minimally invasive technique, has been used for the treatment of HH-related epilepsy. Read More
Phys Chem Chem Phys 2018 Nov;20(46):29299-29305
Department of Physics, City University of Hong Kong, Hong Kong SAR, China.
The exciton formation dynamics of several model silicon nanosheets (SiNSs) are investigated using a time-dependent density functional tight binding method. The first excited-state (S1) self-trapped exciton formation in the SiNSs is obtained by observing the frontier orbital localization related to the characteristic size of the electronic excitations. The frontier molecular orbitals are highly localized in the S1 state on the stretched Si-Si bond due to the photo-excited structural relaxation, leading to a significant Stokes shift. Read More
Interact Cardiovasc Thorac Surg 2018 Sep 20. Epub 2018 Sep 20.
Department of Thoracic Surgery, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Objectives: We report our initial technical experience with computed tomography (CT)-guided cyanoacrylate localization for resection of small pulmonary nodules (SPNs) and evaluate the feasibility of this technique.
Methods: Between June 2016 and December 2017, the diagnostic results of 55 consecutive patients (69 SPNs) who underwent preoperative CT-guided cyanoacrylate localization and consequent video-assisted thoracoscopic surgery (VATS) resection were retrospectively evaluated. Localization-related outcomes and perioperative outcomes were assessed. Read More
Korean J Radiol 2018 Sep-Oct;19(5):965-977. Epub 2018 Aug 6.
Department of Imaging Sciences & Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Trivandrum 695011, India.
Accurate identification of the epileptogenic zone is an important prerequisite in presurgical evaluation of refractory epilepsy since it affects seizure-free outcomes. Apart from structural magnetic resonance imaging (sMRI), delineation has been traditionally done with electroencephalography and nuclear imaging modalities. Arterial spin labelling (ASL) sequence is a non-contrast magnetic resonance perfusion technique capable of providing similar information. Read More
J Neurosurg Pediatr 2018 Oct 20;22(4):444-452. Epub 2018 Jul 20.
Division of Pediatric Neurosurgery, Department of Neurological Surgery, Children's Hospital of New York, Columbia-Presbyterian, New York.
Objective: Patients with medically refractory localization-related epilepsy (LRE) may be candidates for surgical intervention if the seizure onset zone (SOZ) can be well localized. Stereoelectroencephalography (SEEG) offers an attractive alternative to subdural grid and strip electrode implantation for seizure lateralization and localization; yet there are few series reporting the safety and efficacy of SEEG in pediatric patients.
Methods: The authors review their initial 3-year consecutive experience with SEEG in pediatric patients with LRE. Read More
Seizure 2018 Aug 26;60:29-38. Epub 2018 May 26.
ACE Kempenhaeghe/MUMC+, Dep. of Epileptology, Loc Heeze, The Netherlands; UGent, Dep. of Neurology, Gent, Belgium.
Purpose: To study possible detection of structural abnormalities on 7T MRI that were not detected on 3T MRI and estimate the added value of MEG-guidance. For abnormalities found, analysis of convergence between clinical, MEG and 7T MRI localization of suspected epileptogenic foci.
Methods: In adult patients with well-documented localization-related epilepsy in whom a previous 3T MRI did not demonstrate an epileptogenic lesion but MEG indicated a plausible epileptogenic focus, 7T MRI was performed. Read More
Acta Neurochir (Wien) 2018 Sep 1;160(9):1875-1882. Epub 2018 Jun 1.
Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Nakaku, Hamamatsu, Shizuoka, 430-8558, Japan.
Background: When the results of electroencephalography (EEG), magnetic resonance imaging (MRI), and seizure semiology are discordant or no structural lesion is evident on MRI, single-photon emission computed tomography (SPECT) and positron emission tomography (PET) are important examinations for lateralization or localization of epileptic regions. We hypothesized that the concordance between interictal 2-[F]fluoro-2-deoxy-D-glucose (FDG)-PET and iomazenil (IMZ)-SPECT could suggest the epileptogenic lobe in patients with non-lesional findings on MRI.
Method: Fifty-nine patients (31 females, 28 males; mean age, 29 years; median age, 27 years; range, 7-56 years) underwent subdural electrode implantation followed by focus resection. Read More
Brain Lang 2018 Mar 30. Epub 2018 Mar 30.
Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. Electronic address:
Purpose: To examine the impact of diverse syndromes of focal and generalized epilepsy on language function in children with new and recent onset epilepsy. Of special interest was the degree of shared language abnormality across epilepsy syndromes and the unique effects associated with specific epilepsy syndromes.
Methods: Participants were 136 youth with new or recent-onset (diagnosis within past 12 months) epilepsy and 107 healthy first-degree cousin controls. Read More
J Neurophysiol 2018 Jun 28;119(6):2068-2081. Epub 2018 Feb 28.
Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, Pennsylvania.
New devices that use targeted electrical stimulation to treat refractory localization-related epilepsy have shown great promise, although it is not well known which targets most effectively prevent the initiation and spread of seizures. To better understand how the brain transitions from healthy to seizing on a local scale, we induced focal epileptiform activity in the visual cortex of five anesthetized cats with local application of the GABA blocker picrotoxin while simultaneously recording local field potentials on a high-resolution electrocorticography array and laminar depth probes. Epileptiform activity appeared in the form of isolated events, revealing a consistent temporal pattern of ictogenesis across animals with interictal events consistently preceding the appearance of seizures. Read More
Epilepsy Behav 2018 03 3;80:157-162. Epub 2018 Feb 3.
Department of Psychology, University of Toronto, Toronto, Ontario, Canada; Department of Psychology, Hospital for Sick Children, Toronto, Ontario, Canada; Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:
Objective: Previous findings have been mixed in terms of identifying a distinct pattern of neuropsychological deficits in children with frontal lobe epilepsy (FLE) and in those with temporal lobe epilepsy (TLE). The current study investigated the neuropsychological similarities and differences across these two pediatric medically intractable localization-related epilepsies.
Method: Thirty-eight children with FLE, 20 children with TLE, and 40 healthy children (HC) participated in this study. Read More
Epilepsy Behav 2018 03 3;80:5-10. Epub 2018 Feb 3.
Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Youth with epilepsy demonstrate deficits in executive functioning (EF), the skills necessary for goal-directed behavior (e.g., problem-solving, initiating, monitoring, organization, planning, and working memory). Read More
Int J Surg 2018 Mar 3;51:24-30. Epub 2018 Feb 3.
Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background: Small pulmonary nodules (SPNs) often cannot be accurately located during video-assisted thoracoscopic (VATS) resection, and preoperative computed tomography (CT)-guided localization performed using hook wire placement can be helpful. However, recent studies revealed a trend towards more frequent and severe complications occurring in association with hook wire insertion. The aim of this study is to reevaluate the safety, and reliability of the preoperative CT-guided hook wire localization technique and also identify the risk factors for localization-related pneumothorax. Read More
J Vis Exp 2017 12 30(130). Epub 2017 Dec 30.
Departamento de Histología y Embriología, Facultad de Medicina, Laboratorio de Biología del Desarrollo.
Wing development in Drosophila melanogaster is an ideal model for studying morphogenesis at tissue level. These appendages develop from a group of cells named wing imaginal discs formed during embryonic development. In the larval stages the imaginal discs grow, increasing its number of cells and forming monolayered epithelial structures. Read More
Neurosurg Rev 2018 Jan 6. Epub 2018 Jan 6.
Department of Neurosurgery, Academic Center for Epileptology (ACE), Maastricht University Medical Center, Maastricht (MUMC), PO Box 5800, 6202, AZ, Maastricht, The Netherlands.
Despite the use of first-choice anti-epileptic drugs and satisfactory seizure outcome rates after resective epilepsy surgery, a considerable percentage of patients do not become seizure free. ANT-DBS may provide for an alternative treatment option in these patients. This literature review discusses the rationale, mechanism of action, clinical efficacy, safety, and tolerability of ANT-DBS in drug-resistant epilepsy patients. Read More
J Korean Med Sci 2018 Jan 15;33(3):e17. Epub 2018 Jan 15.
Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Background: In this study, we aimed to identify cognitive function and neuropsychological comorbidities in children with newly diagnosed idiopathic epilepsy.
Methods: We retrospectively reviewed the records of 97 antiepileptic drug-naïve children (9.7 ± 2. Read More
Epilepsy Res 2018 01 2;139:85-91. Epub 2017 Dec 2.
Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, USA. Electronic address:
Objective: To test the hypothesis that localization-related epilepsy is associated with widespread neuronal dysfunction beyond the ictal focus, reflected by a decrease in patients' global concentration of their proton MR spectroscopy (H-MRS) observed marker, N-acetyl-aspartate (NAA).
Methods: Thirteen patients with localization-related epilepsy (7 men, 6 women) 40±13 (mean±standard-deviation)years old, 8.3±13. Read More
Curr Opin Neurol 2017 Dec;30(6):580-586
Department of Neurological Surgery, UC Davis Medical Center, University of California, Sacramento, California, USA.
Purpose Of Review: Posttraumatic seizures (PTS) and posttraumatic epilepsy (PTE) are common and debilitating consequences of traumatic brain injury (TBI). Early PTS result in secondary brain injury by raising intracranial pressure and worsening cerebral edema and metabolic crisis. PTE is a localization-related epilepsy strongly associated with TBI severity, but risk factors for PTE and epileptogenesis are incompletely understood and are active areas of research. Read More
J Neurosurg Pediatr 2017 Dec 13;20(6):575-582. Epub 2017 Oct 13.
Comprehensive Epilepsy Program, Dell Children's Hospital, Austin; and.
OBJECTIVE Seizure onset within the insula is increasingly recognized as a cause of intractable epilepsy. Surgery within the insula is difficult, with considerable risks, given the rich vascular supply and location near critical cortex. MRI-guided laser interstitial thermal therapy (LiTT) provides an attractive treatment option for insular epilepsy, allowing direct ablation of abnormal tissue while sparing nearby normal cortex. Read More
Brain 2017 10;140(10):2639-2652
Aix Marseille Univ, CNRS, CRMBM UMR 7339, Marseille, France.
See Bernasconi (doi:10.1093/brain/awx229) for a scientific commentary on this article. Drug-resistant localization-related epilepsies are now recognized as network diseases. Read More
Epilepsia 2017 11 4;58(11):e152-e156. Epub 2017 Sep 4.
Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.
We examined cognition in aging persons with chronic epilepsy; characterized targeted vascular, inflammatory, and metabolic risk factors associated with abnormal cognitive aging in the general population; and examined associations between cognition and vascular, inflammatory, and metabolic health. Participants included 40 persons with chronic localization-related epilepsy and 152 controls, aged 54.6 and 55. Read More
Epilepsy Behav 2017 10 12;75:1-5. Epub 2017 Aug 12.
Department of Psychiatry, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
Background: Dysphoric disorder (DD), characterized by intermittent pleomorphic symptoms, has been believed to be specific to epilepsy. However, our previous study revealed that DD in patients with localization-related epilepsy was associated with a lifetime diagnosis of mood disorders. The present study was conducted to estimate the prevalence of DD in patients with mood disorders, but not epilepsy, and to identify the clinical similarities and differences of DD in patients with either epilepsy or mood disorders. Read More
Brain Connect 2017 09;7(7):424-442
5 Department of Pediatric Neurosurgery, Texas Children's Hospital , Baylor College of Medicine, Houston, Texas.
The purpose of this study was to prospectively investigate the agreement between the epileptogenic zone(s) (EZ) localization by resting-state functional magnetic resonance imaging (rs-fMRI) and the seizure onset zone(s) (SOZ) identified by intracranial electroencephalogram (ic-EEG) using novel differentiating and ranking criteria of rs-fMRI abnormal independent components (ICs) in a large consecutive heterogeneous pediatric intractable epilepsy population without an a priori alternate modality informing EZ localization or prior declaration of total SOZ number. The EZ determination criteria were developed by using independent component analysis (ICA) on rs-fMRI in an initial cohort of 350 pediatric patients evaluated for epilepsy surgery over a 3-year period. Subsequently, these rs-fMRI EZ criteria were applied prospectively to an evaluation cohort of 40 patients who underwent ic-EEG for SOZ identification. Read More
Epilepsy Behav 2017 09 18;74:73-75. Epub 2017 Jul 18.
Kerala Registry of Epilepsy and Pregnancy, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India. Electronic address:
We aimed to study the epileptiform discharges (ED) and seizure risk in EEG of 12-18-year-old children of women with epilepsy (WWE). Children of WWE who were prospectively followed up in the Kerala registry of epilepsy and pregnancy (KREP), aged 12-16years (n=92; males 48, females 44) underwent clinical evaluation and a 30-min digital 18-channel EEG. The EEG showed epileptiform discharges in 13 children (5 males and 8 females). Read More
J Clin Neurosci 2017 Oct 12;44:214-217. Epub 2017 Jul 12.
Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address:
The aim of this study was to determine the clinical importance and predictors of SCSs in a large population of patients with temporal epilepsy (TLE) undergoing video electroencephalographic (VEEG) monitoring. We reviewed the VEEG data of 327 consecutive patients with TLE admitted to our epilepsy center between August 2012 and January 2017. Demographic, electro-clinical, and neuroimaging data were recorded and re-analyzed. Read More
Epilepsy Behav 2017 08 18;73:137-141. Epub 2017 Jul 18.
Duke University Medical Center, Division of Pediatric Neurology, Durham, NC 27710, United States. Electronic address:
Objectives: To describe the characteristics of epilepsy in patients with Neurofibromatosis type 1 (NF1).
Methods: Analysis of a cohort of consecutive NF1 patients seen in our NF1 clinic during a three-year period.
Results: Of the 184 NF1 patients seen during that period, 26 had epilepsy and three had febrile seizures. Read More
Neurosurgery 2018 Jun;82(6):833-841
Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, Florida.
Background: Surgery is indicated in cases of mesial temporal lobe epilepsy(MTLE) that are refractory to medical management. The inferior temporal gyrus (ITG) approach provides access to the mesial temporal lobe (MTL) structures with minimal tissue disruption. Reported neuropsychology outcomes following this approach are limited. Read More
Pediatr Radiol 2017 Oct 16;47(11):1500-1507. Epub 2017 May 16.
Department of Radiology, Texas Children's Hospital, 6621 Fannin St., #470, Houston, TX, 77030, USA.
Background: There is great interest in positron emission tomography (PET)/magnetic resonance (MR) as a clinical tool due to its capacity to provide diverse diagnostic information in a single exam.
Objective: The goal of this exam is to compare the diagnostic accuracy of PET/MR-acquired [F-18]2-fluoro-2-deoxyglucose (FDG) brain exams to that of PET/CT with respect to identifying seizure foci in children with localization-related epilepsy.
Materials And Methods: Institutional Review Board approval and informed consent were obtained for this Health Insurance Portability and Accountability Act-compliant, prospective study. Read More
Brain Dev 2017 Sep 6;39(8):678-686. Epub 2017 May 6.
Department of Pediatrics, St. Marianna University School of Medicine, Japan.
Introduction: Epilepsy is considered to arise from dysfunction in neural networks. Recent advances in neuroimaging and its analysis have made it possible to investigate both functional and structural connectivity in the brain. The aim of this study was to elucidate alterations in the structural connectivity in children with localization-related epilepsy using the mathematical method of graph theoretical analysis. Read More
Noro Psikiyatr Ars 2016 Sep 1;53(3):213-221. Epub 2016 Mar 1.
Department of Neurology, Hacettepe University School of Medicine, Ankara, Turkey.
Introduction: Specialized centers, in the management and surgical treatment of medically refractory epilepsy, emphasize the importance of differentiating the varieties of localization related epilepsies. There has been considerable recent interest in temporal and frontal lobe epileptic syndromes and less attention has been paid to parietal and occipital lobe epilepsies.
Methods: Here we report the clinical, electroencephalographic and neuroimaging characteristics of 46 patients with medically refractory lesional parietal lobe epilepsy who have been followed up for 1-10 years. Read More
Epilepsy Res 2017 05 2;132:34-40. Epub 2017 Mar 2.
New York University School of Medicine, Department of Neurology, Epilepsy Division, New York, NY, 10016, United States; St. Georges University School of Medicine, Department of Behavioral Sciences, St. Georges, Grenada.
Objective: Amygdala enlargement (AE) is observed in patients with temporal lobe epilepsy (TLE), which has led to the suggestion that it represents a distinct TLE subtype; however, it is unclear whether AE is found at similar rates in other epilepsy syndromes or in healthy controls, which would limit its value as a marker for focal epileptogenicity.
Methods: We compared rates of AE, defined quantitatively from high-resolution T1-weighted MRI, in a large multi-site sample of 136 patients with nonlesional localization related epilepsy (LRE), including TLE and extratemporal (exTLE) focal epilepsy, 34 patients with idiopathic generalized epilepsy (IGE), and 233 healthy controls (HCs).
Results: AE was found in all groups including HCs; however, the rate of AE was higher in LRE (18. Read More
Sci Rep 2017 02 1;7:40640. Epub 2017 Feb 1.
Department of Diagnostic and Interventional Radiology, Leipzig University Hospital, Liebigstraße 20 Leipzig, Germany.
This work aims to assess the impact of an additional endorectal coil on image quality and cancer detection rate within the same patients. At a single academic medical center, this transversal study included 41 men who underwent T2- and diffusion-weighted imaging at 3 T using surface coils only or in combination with an endorectal coil in the same session. Two blinded readers (A and B) randomly evaluated all image data in separate sessions. Read More
Epilepsy Behav 2017 03 19;68:41-44. Epub 2017 Jan 19.
Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Objective: Restless legs syndrome (RLS) is a common neurological movement disorder occurring in approximately 10% of the general population. The prevalence of moderately severe RLS is 2.7% overall (3. Read More
Epilepsy Behav 2017 02 12;67:45-50. Epub 2017 Jan 12.
Department of Psychology, Hospital for Sick Children, Toronto, Ontario, Canada; Neurosciences and Mental Health Program, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada. Electronic address:
Objective: The objective was to evaluate the association of caregiver and family factors with symptoms of anxiety and depression in children and adolescents with medically refractory localization-related epilepsy (i.e., failed at least two epilepsy medications). Read More
Epilepsy Behav 2017 02 10;67:7-12. Epub 2017 Jan 10.
ARC Centre of Excellence in Cognition and its Disorders Sydney, New South Wales, Australia; School of Psychology, The University of Sydney, Australia.
Objective: Attention difficulties are a common clinical complaint among children with epilepsy. We aimed to compare a range of attentional abilities between groups of children with two common epilepsy syndromes, Temporal Lobe Epilepsy (TLE) and Idiopathic Generalized Epilepsy (IGE), and to healthy controls. We also investigated whether epilepsy factors (laterality of seizure focus, epilepsy onset, duration, and severity) were related to attentional abilities. Read More
Epilepsia 2017 01 9;58(1):60-67. Epub 2016 Dec 9.
Biostatistics Collaboration Unit, College of Medicine, Yonsei University, Seoul, Korea.
Objective: We performed a retrospective, prognostic analysis of a cohort of patients with epilepsy according to time of relapse after four seizure-free years.
Methods: Planned withdrawal of antiepileptic drugs (AEDs) and at least 3 years of follow-up after AED discontinuation were performed. The following two groups were assessed: (1) an early relapse (ER) group of patients who experienced recurrence during AED withdrawal and (2) a late relapse (LR) group of patients who experienced recurrence after completion of the AED discontinuation process. Read More
J Back Musculoskelet Rehabil 2016 Apr;29(2):267-271
Background: The Sorensen test is commonly used to assess back muscle endurance capacity. However, the clinical value of this test, requiring compensation of the entire upper body mass, is limited if pain occurs. Therefore, a test variant using only portions of upper body mass could be an alternative. Read More
Acta Neurol Scand 2017 Jul 28;136(1):47-53. Epub 2016 Oct 28.
Department of Behavioral Sciences, Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands.
Objectives: "Epileptic dementia" is reported in adults with childhood-onset refractory epilepsy. Cognitive deterioration can also occur in a "second-hit model".
Materials And Methods: We studied the clinical and neuropsychological characteristics of patients with cognitive deterioration (≥1 SD discrepancy between current IQ and premorbid IQ). Read More
Neurology 2016 Oct 24;87(17):1802-1805. Epub 2016 Sep 24.
From the Department of Neurology, Mayo Clinic, Jacksonville, FL.
Objective: To evaluate and identify the frequency of hand postures during generalized convulsions in patients with genetic generalized epilepsy (GGE), localization-related epilepsy (LRE), and nonepileptic attacks (NEA).
Methods: We retrospectively analyzed 98 consecutive videos of generalized convulsions in 62 patients who were admitted for diagnostic video-EEG monitoring. Demographics were recorded, and hand postures were subdivided into fanning, fisting, index-finger pointing (IFP), clawing, and flaccid posturing. Read More
Acta Neurol Scand 2017 May 18;135(5):533-539. Epub 2016 Oct 18.
The Walton Centre for Neurology and Neurosurgery and University of Liverpool, Liverpool, UK.
Objective: To ascertain efficacy and tolerability of carbamazepine (CBZ), sodium valproate (VPA), lamotrigine (LTG) and levetiracetam (LEV) using the UKAED register (www.ukaed.info). Read More
Epilepsy Behav 2016 11 13;64(Pt A):200-205. Epub 2016 Oct 13.
Departments of Radiology and Nuclear Medicine, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands; School for Mental Health and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. Electronic address:
Objective: Although antiepileptic drugs (AEDs) are effective in suppressing epileptic seizures, they also induce (cognitive) side effects, with mental slowing as a general effect. This study aimed to assess whether concentrations of MR detectable neurotransmitters, glutamate and GABA, are associated with mental slowing in patients with epilepsy taking AEDs.
Methods: Cross-sectional data were collected from patients with localization-related epilepsy using a variety of AEDs from three risk categories, i. Read More
Epilepsy Behav Case Rep 2016 26;6:55-7. Epub 2016 Aug 26.
Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Background: Interictal behavioral symptoms in frontal lobe epilepsy (FLE) are variable and often difficult to discriminate from other localization-related epilepsies.
Methods And Results: We report two female patients with right FLE who exhibited fantastic confabulations. One of the patients had a 14-year history of hypermotor seizures, and the other had a 10-year history of dyscognitive seizures with automatism. Read More
J Clin Neurophysiol 2017 Mar;34(2):144-150
*Department of Neurology, American University of Beirut Medical Center, Beirut, Lebanon; †Division of Neurology, Labib Medical Center, Saida, Lebanon; and ‡Division of Neurology, Rafic Hariri University Hospital, Beirut, Lebanon.
Purpose: The purpose of this study was to assess the frequency of occurrence of a unilateral mu rhythm and the associated neuroimaging findings on dedicated epilepsy protocol brain MRI.
Methods: We retrospectively reviewed the EEG reports database at the American University of Beirut Medical Center between 2011 and 2014 searching for the presence of a unilateral mu rhythm. For patients with a unilateral mu rhythm, we recorded the patients' demographics, number of EEGs performed, characteristics of the mu activity, and the findings on the epilepsy protocol brain MRIs. Read More
Eur J Paediatr Neurol 2016 Nov 18;20(6):880-887. Epub 2016 Jul 18.
Department of Pediatrics, Division of General Pediatrics, MUW, Vienna, Austria. Electronic address:
Background: To describe the rates and types of psychiatric disorders among adolescents with chronic symptomatic epilepsies and to evaluate syndrome-specific differences between temporal lobe (TLE) and frontal lobe (FLE) epilepsies.
Methods: A cross-sectional single-center study design applying the Youth Self Report (YSR) to investigate psychopathological symptoms and the Weinberger Adjustment Inventory (WAI) to investigate personality dimensions was used. Consecutive adolescents between 14 and 18 years of age with drug-resistant symptomatic TLE and FLE were investigated during pre-surgical evaluation prior to epilepsy surgery. Read More
No To Hattatsu 2016 Jul;48(4):253-8
Objective: As a treatment for cases of developmental disorder accompanied with epilepsy, the author examined the efficacy and tolerability of combined administration of levetiracetam (LEV) on the cases. Methods: There were 21 participants (male-to-female-ratio was 16 to 5, 6 in their 10s, 7 in their 20s, 7 in their 30s and 1 in their 40s) to whom LEV was prescribed from October 2011 to December 2014. The effect was classified as loss of seizure, effective (more than 75% reduction in the number of seizures, more than 50% reduction in the number of seizures), unchanged (no change), and aggravation (increase in the number of seizures). Read More
Epilepsy Res 2016 09 31;125:10-8. Epub 2016 May 31.
Departments of Neurology, India. Electronic address:
Purpose: The peri-ictal autonomic disturbances have been studied as predictors of seizure outcome and as markers of seizure onset. We studied the changes in heart rate (HR), HRV, oxygen saturation and blood pressure (BP) in the peri-ictal period in patients with drug-resistant localization-related epilepsy.
Methodology: Ninety one subjects undergoing video-EEG monitoring, underwent continuous HR, SpO2, BP and Lead II ECG monitoring. Read More
J Clin Neurophysiol 2016 Aug;33(4):e28-30
*Department of Neurology, Duke University Medical Center, Durham, North Carolina, U.S.A.; †Neurodiagnostic Center, Durham VA Medical Center, Durham, North Carolina, U.S.A.; and ‡Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina, U.S.A.
MRI-guided laser-interstitial thermal therapy is a new modality for epilepsy surgery. In patients with intractable localization-related seizures, it has been used to ablate epileptogenic lesions with less morbidity than conventional craniotomies, and with potentially similar rates of seizure freedom. It is gaining favor in the treatment of mesial temporal sclerosis, in which the circumscribed epileptic focus is amenable to a stereotactic approach. Read More
Neuropsychiatr Dis Treat 2016 12;12:1111-8. Epub 2016 May 12.
Department of Neurology, Assiut University, Assiut, Egypt.
Background: Epidemiology continues to be an important research tool in the study of epilepsy and related disorders, providing a better understanding of the frequency, causes, and natural history of the disorder.
Objective: To estimate the prevalence of epilepsy in Al-Quseir, Red Sea Governorate, Egypt, and its magnitude of treatment gap.
Methods: The study was part of a door-to-door study, including every door, to screen all inhabitants in Al-Quseir (33,818 inhabitants) by three specialists of neurology and 15 female social workers (for demographic data collection) using a standardized screening questionnaire. Read More
Encephale 2016 Oct 16;42(5):443-447. Epub 2016 May 16.
Clinique neuropsychiatrique, université médicale d'Aichi, 1-1, Yazako Karimata, Nagakute, Aichi, Japon. Electronic address:
Psychosis in epilepsy can be categorized in relation to seizures in two main categories: interictal psychosis and postictal psychosis. Postictal psychosis (PIP) is a specific syndrome in relation to seizure activity: a clear temporal relation exists between the psychotic state of sudden onset and a precipitating bout of complex partial or generalized seizures. However, this very specific syndrome is not included as such within the DSM-5, and PIP belongs to the category "Psychotic disorder due to another medical condition". Read More