10,620 results match your criteria Localization-related Epilepsies on EEG


Focal status epilepticus as unique clinical feature of COVID-19: A case report.

Seizure 2020 May 21;78:109-112. Epub 2020 Apr 21.

Neurologia, Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; Neurologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

SARS-CoV-2, a novel zoonotic coronavirus, is currently spreading all over the world, causing a pandemic disease defined coronavirus disease 2019 (COVID-19). The spectrum of COVID-19 ranges from asymptomatic or mild infection to rapidly progressive, acute respiratory distress syndrome and death [1].To the best of our knowledge, status epilepticus has never been described as initial presentation of COVID-19. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172719PMC

Evaluating Invasive EEG Implantations with Structural Imaging Data and Functional Scalp EEG Recordings from Epilepsy Patients.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:3866-3869

Seizures in patients with medically refractory epilepsy (MRE) cannot be controlled with drugs. For focal MRE, seizures originate in the epileptogenic zone (EZ), which is the minimum amount of cortex that must be treated to be seizure free. Localizing the EZ is often a laborious process wherein clinicians first inspect scalp EEG recordings during several seizure events, and then formulate an implantation plan for subsequent invasive monitoring. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857241DOI Listing

Effect of Temporal Lobe Epilepsy on Auditory-motor Integration for Vocal Pitch Regulation: Evidence from Brain Functional Network Analysis.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:3849-3853

Temporal lobe epilepsy (TLE) is a medically refractory focal epilepsy associated with structural deficits. Considerable evidence has revealed that patients with TLE also exhibit deficits in functional connectivity. According to previous research, patients with TLE exhibited decreased performance in speech sound perception and auditory-motor integration for voice control, which might be related to the compromised brain network connectivity. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8856902DOI Listing

Ongoing intracortical neural activity predicts upcoming interictal epileptiform discharges in human epilepsy.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:2386-2391

Interictal epileptiform discharges (IEDs) are a hallmark of focal epilepsies. Most previous studies have focused on whether IED events increase seizure likelihood or, on the contrary, act as a protective mechanism. Here, we study instead whether IED events themselves can be predicted based on measured ongoing neural activity. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857513DOI Listing

Benign Rolandic epilepsy: widespread increases in connectivity in a focal epilepsy syndrome.

Epileptic Disord 2019 Dec;21(6):567-578

Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

Benign Rolandic epilepsy (benign epilepsy with centrotemporal spikes; recently renamed self-limited epilepsy with centrotemporal spikes) is associated with widespread deficits in cognition and behavior, suggesting abnormalities in networks that extend beyond the centrotemporal region. To assess functional connectivity in children with benign Rolandic epilepsy, we assessed EEG spectral power and coherence during awake and sleep records in 27 children with centrotemporal spikes. Coherence represents the consistency of the phase difference between two EEG signals when compared over time and serves as a measure of synchronization between two EEG signals based mainly on phase consistency. Read More

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http://dx.doi.org/10.1684/epd.2019.1111DOI Listing
December 2019

Ictal asystole with intercurrent cardiopathy: a complex combination leading to delayed diagnosis.

Epileptic Disord 2019 Dec;21(6):598-602

Centre de recherche du Centre Hospitalier de l'Université de Montréal,, Division of Neurology, Centre Hospitalier de l'Université de Montréal.

Ictal asystole is a rare epileptic phenomenon, though usually self-limiting, which has been associated with an increased risk of sudden death in epileptic patients. Although early recognition is desirable, the diagnosis can be delayed until prolonged video-EEG monitoring is completed. We report a case of ictal asystole in a 74-year-old patient with co-morbid cardiac conditions leading to a delay in diagnosis of approximately 10 years. Read More

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http://dx.doi.org/10.1684/epd.2019.1118DOI Listing
December 2019
5 Reads

Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1.

Mol Brain 2019 12 3;12(1):102. Epub 2019 Dec 3.

Medical Laboratory, Affiliated Hospital, Xuzhou Medical University, No. 99, Huaihai West Road, Xuzhou City, 221002, Jiangsu Province, China.

This study aimed to evaluate the specific regulatory roles of microRNA-146a (miRNA-146a) in temporal lobe epilepsy (TLE) and explore the related regulatory mechanisms. A rat model of TLE was established by intraperitoneal injection of lithium chloride-pilocarpine. These model rats were injected intracerebroventricularly with an miRNA-146a inhibitor and Notch-1 siRNA. Read More

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http://dx.doi.org/10.1186/s13041-019-0523-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892218PMC
December 2019

[Electroclinical characteristics of epilepsy children with midline epileptiform discharges related epileptic negative myoclonus as the first symptom].

Zhonghua Er Ke Za Zhi 2019 Dec;57(12):943-949

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To investigate the electroclinical findings in epilepsy children with epileptic negative myoclonus (ENM) restricted to the lower limb as the first seizure type. Each retrieved electroencephalogram record performed between March 2011 and March 2018 at the Department of Pediatrics of Peking University First Hospital was searched with "midline" . There were 302 records of 175 patients with "benign" or "functional" midline spikes. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.12.009DOI Listing
December 2019

Predictors of Class I epilepsy surgery outcome in tumour-related chronic temporal lobe epilepsy in adults.

Neurol Neurochir Pol 2019 3;53(6):466-475. Epub 2019 Dec 3.

Department of Neurosurgery, Medical University of Warsaw, Warsaw, Poland, Banacha 1a, 02-097 Warsaw, Poland.

Objective: Temporal lobe tumours, especially low-grade gliomas and glioneuronal tumours, are common causes of seizures in patients referred for epilepsy surgery. We here present our experience of surgical treatment of patients with intractable chronic epilepsy associated with temporal lobe tumours, focusing on the long-term surgical outcomes and the features associated with better seizure control.

Methods: In this study, we retrospectively analysed 44 consecutive patients from a total of 182 with refractory temporal lobe epilepsy presenting with long-term intractable epilepsy due to a temporal lobe tumour who were surgically treated at our institution between 2005 and 2015 with post-surgical follow-up of at least two years. Read More

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http://dx.doi.org/10.5603/PJNNS.a2019.0061DOI Listing
January 2020

Localization value of subclinical seizures on scalp video-EEG in epilepsy presurgical evaluation.

Epilepsia 2019 12 21;60(12):2477-2485. Epub 2019 Nov 21.

Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Objective: To evaluate the localization value and prognostic significance of subclinical seizures (SCSs) on scalp video-electroencephalography monitoring (VEEG) in comparison to clinical seizures (CSs) in patients who had epilepsy surgery.

Methods: We included 123 consecutive patients who had SCSs and CSs during scalp-VEEG evaluation. All patients had subsequent epilepsy surgery and at least 1-year follow-up. Read More

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http://dx.doi.org/10.1111/epi.16383DOI Listing
December 2019

Classification and management of epilepsy and epileptic syndromes in a cohort of 202 school children- a 2 year follow up study- Sudan.

BMC Neurol 2019 Nov 15;19(1):290. Epub 2019 Nov 15.

Neurology Division, Department of pediatrics and Child Health Faculty of Medicine, University of Khartoum, P. O. Box 102, Khartoum, Sudan.

Background: In this paper, seizure types, and epilepsy syndromes are elucidated as per ILAE (2010) classification. A brief outline of the antiepileptic drug regimens used and the outcome of seizure control in a two -year period is presented. The applicability of the ILAE classification in resource limited countries has been revisited. Read More

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http://dx.doi.org/10.1186/s12883-019-1514-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857133PMC
November 2019

Mild chronic perturbation of inhibition severely alters hippocampal function.

Sci Rep 2019 11 11;9(1):16431. Epub 2019 Nov 11.

Department of Psychiatry, Washington University School of Medicine, St. Louis, USA.

Pentameric GABA receptors mediate a large share of CNS inhibition. The γ2 subunit is a typical constituent. At least 11 mutations in the γ2 subunit cause human epilepsies, making the role of γ2-containing receptors in brain function of keen basic and translational interest. Read More

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http://dx.doi.org/10.1038/s41598-019-52851-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848214PMC
November 2019
5.078 Impact Factor

Ictal kissing in a patient with right frontal lobe epilepsy.

Epileptic Disord 2019 Oct;21(5):453-457

Neurophisiology Unit, Neurology Service, Centro Hospitalar Universitário de São João, Porto.

When performing pre-surgical evaluation of patients with refractory epilepsy, the analysis of seizure semiology is one of the key elements used to generate a hypothesis about the location of the epileptogenic zone. Ictal kissing is a very rarely observed ictal automatism described in patients with temporal lobe epilepsy. We present a 62-year-old man who was referred to our epilepsy centre for comprehensive evaluation. Read More

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http://dx.doi.org/10.1684/epd.2019.1097DOI Listing
October 2019
3 Reads

Evolution of concepts in epilepsy surgery.

Authors:
Jerome Engel

Epileptic Disord 2019 Oct;21(5):391-409

Departments of Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences, and the Brain Research Institute, David Geffen School of Medicine, UCLA.

At the time of the first meeting of the International League Against Epilepsy (ILAE) in 1909, surgical treatment for epilepsy had been accepted as an alternative therapy for over two decades, but was rarely practiced, considered a last resort for carefully selected patients. Localization was based on ictal semiology and identification of a structural lesion. Very few papers on epilepsy surgery were presented at ILAE meetings or published in Epilepsia during the first half of the 20 century. Read More

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http://dx.doi.org/10.1684/epd.2019.1091DOI Listing
October 2019

Learning to see the invisible: A data-driven approach to finding the underlying patterns of abnormality in visually normal brain magnetic resonance images in patients with temporal lobe epilepsy.

Epilepsia 2019 12 6;60(12):2499-2507. Epub 2019 Nov 6.

Department of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, University College London, London, UK.

Objective: To find the covert patterns of abnormality in patients with unilateral temporal lobe epilepsy (TLE) and visually normal brain magnetic resonance images (MRI-negative), comparing them to those with visible abnormalities (MRI-positive).

Methods: We used multimodal brain MRI from patients with unilateral TLE and employed contemporary machine learning methods to predict the known laterality of seizure onset in 104 subjects (82 MRI-positive, 22 MRI-negative). A visualization approach entitled "Importance Maps" was developed to highlight image features predictive of seizure laterality in both the MRI-positive and MRI-negative cases. Read More

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http://dx.doi.org/10.1111/epi.16380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972547PMC
December 2019

Minimally Invasive Technique (Nummular Craniotomy) for Mesial Temporal Lobe Epilepsy: A Comparison of 2 Approaches.

World Neurosurg 2020 Feb 2;134:e636-e641. Epub 2019 Nov 2.

Department of Neurosurgery, University of São Paulo, São Paulo, Brazil. Electronic address:

Objective: To describe our series of a minimally invasive technique using a small scalp incision and keyhole craniotomy for the removal of mesial temporal lobe structures through a transcortical approach in patients with medically intractable mesial temporal lobe epilepsy (MTLE). Studies that directly compare the clinical outcomes between minimally invasive and conventional techniques are scarce, and this information is lacking in the literature.

Methods: The study enrolled 73 consecutive patients with refractory MTLE and unilateral hippocampal sclerosis; 30 patients were operated on with standard frontotemporal craniotomy between 2010 and 2013 and 43 patients were operated with a minimally invasive craniotomy (nummular craniotomy) between 2014 and 2016. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.160DOI Listing
February 2020

The network integration of epileptic activity in relation to surgical outcome.

Clin Neurophysiol 2019 12 14;130(12):2193-2202. Epub 2019 Oct 14.

EEG and Epilepsy, Neuroscience Department, University Hospital and Faculty of Medicine of Geneva, Geneva, Switzerland. Electronic address:

Objective: Epilepsy is a network disease with epileptic activity and cognitive impairment involving large-scale brain networks. A complex network is involved in the seizure and in the interictal epileptiform discharges (IEDs). Directed connectivity analysis, describing the information transfer between brain regions, and graph analysis are applied to high-density EEG to characterise networks. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.09.006DOI Listing
December 2019
3.097 Impact Factor

[Clinical characteristics of PCDH19-female limited epilepsy].

Zhonghua Er Ke Za Zhi 2019 Nov;57(11):857-862

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To analyze the clinical characteristics of patients with PCDH19-female limited epilepsy (PCDH19-FE). The clinical data of 60 female epilepsy patients with PCDH19 gene heterozygous variations at the Department of Pediatrics, Peking University First Hospital from October 2007 to December 2018 were collected and analyzed retrospectively, their clinical manifestations, accessory examination and follow-up treatment were summarized. Data of a total of 60 cases of PCDH19-FE were collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.11.008DOI Listing
November 2019
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High frequency oscillations in MEG: next steps in source imaging for focal epilepsy.

Brain 2019 11;142(11):3318-3320

University Medical Centre Utrecht, Neurology, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/brain/awz321DOI Listing
November 2019

Insular cortex: Functional complexity and clinical correlations.

Neurology 2019 11 23;93(21):932-938. Epub 2019 Oct 23.

From the Department of Neurology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000008525DOI Listing
November 2019

Brain-heart interactions considering complex physiological data: processing schemes for time-variant, frequency-dependent, topographical and statistical examination of directed interactions by convergent cross mapping.

Physiol Meas 2019 12 2;40(11):114001. Epub 2019 Dec 2.

Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.

Background: A multitude of complex methods is available to quantify interactions in highly complex physiological systems. Brain-heart interactions play an important role in identifying couplings between the central nervous system and the autonomic nervous system during defined physiological states or specific diseases. The crucial point of those interaction analyses is adequate pre-processing taking into account nonlinearity of data, intuitive graphical representation and suitable statistical evaluation of the achieved results. Read More

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http://dx.doi.org/10.1088/1361-6579/ab5050DOI Listing
December 2019
1 Read

Self-stimulation in an adult misdiagnosed with focal epilepsy.

Epileptic Disord 2019 Oct;21(5):463-465

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

Self-stimulation is a normal part of development and a common behaviour in children before puberty, but very rare in adults. The stereotyped semiology can sometimes raise the suspicion of epilepsy. We present a 30-year-old patient who came to our epilepsy monitoring unit for differential diagnosis of nocturnal episodes, interpreted elsewhere as hypermotor status epilepticus associated with a known diagnosis of focal epilepsy and septo-optic dysplasia. Read More

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http://dx.doi.org/10.1684/epd.2019.1099DOI Listing
October 2019
1 Read

[Newer studies on the strong link between sleep and epilepsy: Epilepsy as an epileptic transformation of sleep plastic functions].

Authors:
Péter Halász

Ideggyogy Sz 2019 Sep;72(9-10):304-314

Országos Klinikai Idegtudományi Intézet, Budapest.

Aims - Overview of the new data about the strong link of sleep and epilepsy and conjoining cognitive impairment. Methods - Search for relevant references and summary of our own research activity on the topic. Results - Strong interrealtionship exists between epilepsy and plastic brain functions (memory processing and synaptic homeostasis) and the working modes of NREM sleep. Read More

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http://dx.doi.org/10.18071/isz.72.0304DOI Listing
September 2019

[Clinico-pathological features of temporal lobe epilepsy with enlarged amygdala].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Oct;51(5):824-828

Department of Neurology, Peking University International Hospital, Beijing 102206, China.

Objective: To summarize the clinical, video electroencephalogram (VEEG), radiological and pathological features of 3 patients of temporal lobe epilepsy (TLE) with amygdala enlargement (AE).

Methods: Three TLE patients with AE who were hospitalized in Peking University International Hospital were collected. The above features were retrospectively analyzed, and the amygdala volume was measured as well. Read More

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October 2019
4 Reads

Ketogenic parenteral nutrition in three paediatric patients with epilepsy with migrating focal seizures.

Epileptic Disord 2019 Oct;21(5):443-448

Department of Neurology, Hospital Pediatria JP Garrahan, Buenos Aires, Argentina.

Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare epilepsy syndrome, characterized by an onset of multifocal seizures before the age of six months and a rather typical ictal EEG pattern. The ketogenic diet (KD) has been shown to be a treatment option in these patients with variable results. The KD is generally given by enteral formula or solid food, however, patients on the KD often have coexisting medical disorders that may impair the gastrointestinal tract and, in these cases, parenteral nutrition support may be needed. Read More

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http://dx.doi.org/10.1684/epd.2019.1095DOI Listing
October 2019
1 Read

Generalized quasiperiodic epileptiform activity in sleep is associated with cognitive impairment in children with drug-resistant focal lesional epilepsy.

Epilepsia 2019 11 15;60(11):2263-2276. Epub 2019 Oct 15.

Second Faculty of Medicine, Charles University Prague, Prague, Czech Republic.

Objective: To evaluate the impact of generalized quasiperiodic epileptiform discharges ("hurdles") observed in non-rapid eye movement (NREM) sleep on cognitive function in children with intractable focal epilepsy. "Hurdles" pattern does not meet the criteria of the electrical status epilepticus in slow-wave sleep (ESES).

Methods: In a retrospective analysis, 24 patients with "hurdles" and their 24 peers matched for demographic and epilepsy-related variables were compared in terms of neuropsychological domains and electroencephalography (EEG)-derived quantifiers. Read More

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http://dx.doi.org/10.1111/epi.16362DOI Listing
November 2019
1 Read

Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy.

Epilepsia 2019 11 13;60(11):2314-2324. Epub 2019 Oct 13.

4Brain, Department of Neurology, Ghent University, Ghent, Belgium.

Objective: More than one-third of patients with temporal lobe epilepsy (TLE) continue to have seizures despite treatment with antiepileptic drugs, and many experience severe drug-related side effects, illustrating the need for novel therapies. Selective expression of inhibitory Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) allows cell-type-specific reduction of neuronal excitability. In this study, we evaluated the effect of chemogenetic suppression of excitatory pyramidal and granule cell neurons of the sclerotic hippocampus in the intrahippocampal mouse model (IHKA) for temporal lobe epilepsy. Read More

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http://dx.doi.org/10.1111/epi.16368DOI Listing
November 2019
1 Read

Stereo-EEG ictal/interictal patterns and underlying pathologies.

Seizure 2019 Nov 5;72:54-60. Epub 2019 Oct 5.

Claudio MunariEpilepsy Surgery Centre, Niguarda Hospital, Piazza Ospedale Maggiore 3, 20162 Milan, Italy. Electronic address:

Purpose: To define Stereo-EEG (SEEG) ictal and interictal patterns associated with different pathologies in a cohort of patients with drug-resistant focal epilepsy.

Methods: We retrospectively analyzed findings from 102 patient with epilepsy due to Polymicrogyria (PMG), Periventricular Nodular Heterotopia (PNH), Focal Cortical Dysplasia (FCD) type I, IIa, IIb and Hippocampal Sclerosis (HS). Ictal and interictal SEEG recordings were reviewed to describe Seizure Onset Zone (SEEG-SOZ) patterns and to define the Lesional and Irritative Zones. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.10.001DOI Listing
November 2019
1 Read
2.059 Impact Factor

[Clinical and genetic characteristics of focal epilepsy in children caused by GATOR1 complex gene variation].

Zhonghua Er Ke Za Zhi 2019 Oct;57(10):780-785

Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To summarize the clinical and genetic characteristics of focal epilepsy in children caused by GATOR1 complex gene variation. The clinical data, gene variation and treatment outcome of 12 children with focal epilepsy caused by GATOR1 complex gene variation admitted to Beijing Children's Hospital Affiliated to Capital Medical University from June 2016 to October 2018 were retrospectively analyzed. There were 7 males and 5 females in 12 cases. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.10.010DOI Listing
October 2019
3 Reads

Hypothalamic hamartomas in adulthood: Clinical spectrum and treatment outcome-A unicenter experience.

Brain Behav 2019 11 2;9(11):e01412. Epub 2019 Oct 2.

Epilepsy Unit, Department of Neurology, Hospital Clinic, Barcelona, Spain.

Introduction: Clinical manifestations of the hypothalamic hamartoma-epilepsy syndrome (HH-ES) in adulthood are variable. Efficacy of therapeutic options and outcome are diverse.

Methods: Retrospective study of adult patients diagnosed with a HH in magnetic resonance imaging and epilepsy who attended our tertiary Epilepsy Unit between 2003 and 2018. Read More

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http://dx.doi.org/10.1002/brb3.1412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851795PMC
November 2019
1 Read

Prospective observational study: Fast ripple localization delineates the epileptogenic zone.

Clin Neurophysiol 2019 11 17;130(11):2144-2152. Epub 2019 Sep 17.

Division of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine, Los Angeles, CA, USA.

Objective: To investigate spatial correlation between interictal HFOs and neuroimaging abnormalities, and to determine if complete removal of prospectively identified interictal HFOs correlates with post-surgical seizure-freedom.

Methods: Interictal fast ripples (FRs: 250-500 Hz) in 19 consecutive children with pharmacoresistant focal epilepsy who underwent extra-operative electrocorticography (ECoG) recording were prospectively analyzed. The interictal FRs were sampled at 2000 Hz and were visually identified during 10 min of slow wave sleep. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.08.026DOI Listing
November 2019
2 Reads

Multiple Oscillatory Push-Pull Antagonisms Constrain Seizure Propagation.

Ann Neurol 2019 11 30;86(5):683-694. Epub 2019 Sep 30.

Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA.

Objective: Drug-resistant focal epilepsy is widely recognized as a network disease in which epileptic seizure propagation is likely coordinated by different neuronal oscillations such as low-frequency activity (LFA), high-frequency activity (HFA), or low-to-high cross-frequency coupling. However, the mechanism by which different oscillatory networks constrain the propagation of focal seizures remains unclear.

Methods: We studied focal epilepsy patients with invasive electrocorticography (ECoG) recordings and compared multilayer directional network interactions between focal seizures either with or without secondary generalization. Read More

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http://dx.doi.org/10.1002/ana.25583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856814PMC
November 2019
1 Read

KCNT1 epilepsy with migrating focal seizures shows a temporal sequence with poor outcome, high mortality and SUDEP.

Brain 2019 10;142(10):2996-3008

Reference Centre for Rare Epilepsies, Department of Pediatric Neurology, Necker Enfants Malades Hospital, Paris Descartes University, Paris, France.

Epilepsy of infancy with migrating focal seizures was first described in 1995. Fifteen years later, KCNT1 gene mutations were identified as the major disease-causing gene of this disease. Currently, the data on epilepsy of infancy with migrating focal seizures associated with KCNT1 mutations are heterogeneous and many questions remain unanswered including the prognosis and the long-term outcome especially regarding epilepsy, neurological and developmental status and the presence of microcephaly. Read More

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http://dx.doi.org/10.1093/brain/awz240DOI Listing
October 2019
2 Reads

Optimized SEEG-guided radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis.

Seizure 2019 Oct 30;71:304-311. Epub 2019 Aug 30.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University (CMU), Beijing, China; Beijing Institute for Brain Disorders, Beijing, China. Electronic address:

Purpose: Concerns about the impact of open surgery for drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) have driven interest in minimally invasive techniques. Stereo-electro-encephalography guided radiofrequency thermocoagulation (SEEG guided RF-TC) offers an alternative choice but with currently limited efficacy. We developed a procedure for optimally extended thermocoagulative lesions and investigated the efficacy and safety for MTLE-HS in a preliminary observational study. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.08.011DOI Listing
October 2019
1 Read

Drug-responsive versus drug-refractory mesial temporal lobe epilepsy: a single-center prospective outcome study.

Postgrad Med 2019 Sep 12;131(7):479-485. Epub 2019 Sep 12.

Department of Clinical Neurophysiology and Epilepsies, Guy's and St. Thomas' NHS Foundation Trust , London , UK.

: To evaluate clinical, electrophysiological, and neuroradiological factors which correlate with the prognosis in patients with mesial temporal lobe epilepsy (MTLE). : This was a single-center prospective outcome study in patients with MTLE. The patients' family history, clinical characteristics, neurophysiological data (electroencephalography - EEG), neuroimaging, antiepileptic therapy, and outcome were collected and analyzed. Read More

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http://dx.doi.org/10.1080/00325481.2019.1663126DOI Listing
September 2019
1 Read

Development of Ontology for Self-limited Epilepsy with Centrotemporal Spikes and Application of Data Mining Algorithms to Identify New Subtypes.

Isr Med Assoc J 2019 Jul;21(7):503

Department of Pediatric Neurology, Dana-Dwek Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Benign rolandic epilepsy or benign childhood epilepsy with centrotemporal spikes (BCECTS) is a common childhood epileptic syndrome. The syndrome resolves in adolescence, but 1-7% of patients have an atypical presentation, some of which require aggressive medical treatment. Early treatment may prevent complications and neurocognitive deterioration. Read More

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July 2019
6 Reads

A somatic mutation in MEN1 gene detected in periventricular nodular heterotopia tissue obtained from depth electrodes.

Epilepsia 2019 10 6;60(10):e104-e109. Epub 2019 Sep 6.

Department of Neurology, Baylor College of Medicine, Houston, Texas.

Periventricular nodular heterotopia (PNH) is a common structural malformation of cortical development. Mutations in the filamin A gene are frequent in familial cases with X-linked PNH. However, many cases with sporadic PNH remain genetically unexplained. Read More

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http://dx.doi.org/10.1111/epi.16328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852559PMC
October 2019
3 Reads

High-frequency oscillations in a spectrum of pediatric epilepsies characterized by sleep-activated spikes in scalp EEG.

Clin Neurophysiol 2019 10 19;130(10):1971-1980. Epub 2019 Aug 19.

Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama 700-8558, Japan.

Objective: We studied ripple-band (80-200 Hz) high-frequency oscillations in scalp electroencephalogram (EEG) in various pediatric epilepsies featuring sleep-activated spikes, such as epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS) and investigated their characteristics.

Methods: The subjects were 94 children with epileptic disorders including idiopathic and non-idiopathic CSWS, benign epilepsy with centrotemporal spikes (BECTS), Panayiotopoulos syndrome, other types of focal epilepsies (oFE), and focal spikes without clinical seizures (Latent). We detected ripple oscillations using a semi-automatic detection tool based on localized power increase. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.08.001DOI Listing
October 2019

Spectral organization of focal seizures within the thalamotemporal network.

Ann Clin Transl Neurol 2019 09 30;6(9):1836-1848. Epub 2019 Aug 30.

Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama.

Objective: To investigate dynamic changes in neural activity between the anterior nucleus of the thalamus (ANT) and the seizure onset zone (SOZ) in patients with drug-resistant temporal lobe epilepsy (TLE) based on anatomic location, seizure subtype, and state of vigilance (SOV).

Methods: Eleven patients undergoing stereoelectroencephalography for seizure localization were recruited prospectively for local field potential (LFP) recording directly from the ANT. The SOZ was identified using line length and epileptogenicity index. Read More

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http://dx.doi.org/10.1002/acn3.50880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764631PMC
September 2019
3 Reads

Multi-feature localization of epileptic foci from interictal, intracranial EEG.

Clin Neurophysiol 2019 10 5;130(10):1945-1953. Epub 2019 Aug 5.

Mayo Systems Electrophysiology Laboratory, Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

Objective: When considering all patients with focal drug-resistant epilepsy, as high as 40-50% of patients suffer seizure recurrence after surgery. To achieve seizure freedom without side effects, accurate localization of the epileptogenic tissue is crucial before its resection. We investigate an automated, fast, objective mapping process that uses only interictal data. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759804PMC
October 2019
2 Reads

[Isolated effective coherence analysis of epileptogenic networks in temporal lobe epilepsy using stereo-electroencephalography].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Aug;36(4):541-547

Department of Biomedical Engineering, School of Electrical Engineering, Shenyang University of Technology, Shenyang 110870,

Stereo-electroencephalography (SEEG) is widely used to record the electrical activity of patients' brain in clinical. The SEEG-based epileptogenic network can better describe the origin and the spreading of seizures, which makes it an important measure to localize epileptogenic zone (EZ). SEEG data from six patients with refractory epilepsy are used in this study. Read More

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http://dx.doi.org/10.7507/1001-5515.201806003DOI Listing
August 2019
3 Reads

Lower limb automatism in surgically treated temporal lobe epilepsy patients: Clinical and electrophysiological features.

J Clin Neurosci 2019 Nov 19;69:51-54. Epub 2019 Aug 19.

Hacettepe University, School of Medicine, Department of Neurology, Ankara, Turkey.

Lower limb automatism has not been known well in temporal lobe epilepsy (TLE) patients. This study investigated the distribution of risk factors, EEG features, and pathology types in surgically treated TLE patients. We also made a comparison of this group to surgically treated TLE patients with isolated hand automatism. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.08.038DOI Listing
November 2019

fMRI and electroencephalographic evaluation of sleep deprivation in epilepsy patients: An observational study.

J Clin Neurosci 2019 Nov 16;69:120-123. Epub 2019 Aug 16.

IRCCS Centro Neurolesi "Bonino Pulejo", Contrada Casazza, SS113, 98124 Messina, Italy.

Background: Sleep deprivation (SD) is considered an important activation test to facilitate the visualization of electroencephalogram (EEG) epileptic abnormalities, in order to perform a correct diagnosis.

Objective: The aim of this study was to evaluate the local functional activity in healthy controls (HC) subjects and left mesial temporal lobe epilepsy-hippocampal sclerosis patients, after a SD, by using functional Magnetic Resonance Imaging (fMRI) and EEG.

Materials And Methods: We enrolled 22 healthy controls and 34 patients with a diagnosis of left mesial temporal lobe epilepsy-hippocampal sclerosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868193098
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http://dx.doi.org/10.1016/j.jocn.2019.08.015DOI Listing
November 2019
1 Read

The rough sound of salience enhances aversion through neural synchronisation.

Nat Commun 2019 08 14;10(1):3671. Epub 2019 Aug 14.

Department of Fundamental Neuroscience, University of Geneva - Biotech Campus, Geneva 7, CH-1202, Switzerland.

Being able to produce sounds that capture attention and elicit rapid reactions is the prime goal of communication. One strategy, exploited by alarm signals, consists in emitting fast but perceptible amplitude modulations in the roughness range (30-150 Hz). Here, we investigate the perceptual and neural mechanisms underlying aversion to such temporally salient sounds. Read More

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http://dx.doi.org/10.1038/s41467-019-11626-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694125PMC

Early ictal recruitment of midline thalamus in mesial temporal lobe epilepsy.

Ann Clin Transl Neurol 2019 08 5;6(8):1552-1558. Epub 2019 Jul 5.

Department of Neurology, University of Alabama at Birmingham, Alabama.

The causal role of midline thalamus in the initiation and early organization of mesial temporal lobe seizures is studied. Three patients undergoing stereoelectroencephalography were enrolled for the placement of an additional depth electrode targeting the midline thalamus. The midline thalamus was recruited in all three patients at varying points of seizure initiation (0-13 sec) and propagation (9-60 sec). Read More

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http://dx.doi.org/10.1002/acn3.50835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689686PMC
August 2019
2 Reads

The clinical utility of non-invasive video-electroencephalographic monitoring has been diversifying.

Neurol Sci 2019 Dec 8;40(12):2625-2631. Epub 2019 Aug 8.

Department of Neurology, Keimyung University School of Medicine, Daegu, Republic of Korea.

Background: Inpatient long-term video-electroencephalographic (VEEG) monitoring has been used extensively for differential diagnosis of paroxysmal events. We evaluated the diagnostic yield and clinical utility of VEEG performed in a comprehensive epilepsy center.

Method: We retrospectively reviewed all cases of VEEG performed from May 2003 to April 2018. Read More

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http://link.springer.com/10.1007/s10072-019-04022-y
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http://dx.doi.org/10.1007/s10072-019-04022-yDOI Listing
December 2019
3 Reads

Management of epilepsy in brain tumors.

Neurol Sci 2019 Oct 7;40(10):2217-2234. Epub 2019 Aug 7.

Department of Neurosciences, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

Epilepsy in brain tumors (BTE) may require medical attention for a variety of unique concerns: epileptic seizures, possible serious adverse effects of antineoplastic and antiepileptic drugs (AEDs), physical disability, and/or neurocognitive disturbances correlated to tumor site. Guidelines for the management of tumor-related epilepsies are lacking. Treatment is not standardized, and overall management might differ according to different specialists. Read More

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http://dx.doi.org/10.1007/s10072-019-04025-9DOI Listing
October 2019
13 Reads
1.495 Impact Factor

Tarik Syndrome: Reversible Postoperative Blindness Secondary to Occipital Seizures.

World Neurosurg 2019 Nov 31;131:58-61. Epub 2019 Jul 31.

Department of Neurosurgery, Loyola University Medical Center, Maywood, Illinois, USA.

Background: Postoperative blindness is a devastating surgical complication. Although usually associated with prolonged cardiac and prone spinal operations, it may follow other procedures as well. Postoperative blindness is most commonly caused by a vascular etiology, but it can more rarely be caused by status epilepticus. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.07.186DOI Listing
November 2019
1 Read