10,259 results match your criteria Localization-related Epilepsies on EEG


Seizures and Epilepsy.

Authors:
Emily L Johnson

Med Clin North Am 2019 Mar 3;103(2):309-324. Epub 2018 Dec 3.

Department of Neurology, Johns Hopkins School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address:

Epilepsy affects 65 million people worldwide, and is a leading neurologic cause of loss of quality-adjusted life years. The diagnosis of seizures and epilepsy often depends on a careful history, and is supported with electroencephalogram and imaging. First-line treatment of epilepsy includes medical management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00257125183012
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http://dx.doi.org/10.1016/j.mcna.2018.10.002DOI Listing
March 2019
12 Reads

The utility of Jerk-locked back averaging technique in diagnosis of generalized myoclonic epilepsy with normal scalp EEG: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14185

Department of Neurology, Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, 71, Xinmin Street, Changchun, P. R. China.

Rationale: The diagnosis of myoclonic epilepsy and the classification of generalized or partial type may be challenging, especially when the scalp electroencephalogram (EEG) is normal. In such situation, how to apply another electrophysiological technique to begin the diagnosis and classification? The utility of Jerk-locked back averaging technique has been described in our case.

Patient Concerns: A Chinese patient (male, 21 years old) presented with frequent unilateral or bilateral shoulder-jerking. Read More

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http://dx.doi.org/10.1097/MD.0000000000014185DOI Listing
January 2019

Changes in background electroencephalographic activity in benign childhood epilepsy with centrotemporal spikes after oxcarbazepine treatment: a standardized low-resolution brain electromagnetic tomography (sLORETA) study.

BMC Neurol 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

Background: Several neuroimaging studies have reported neurophysiological alterations in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS). However, reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Moreover, background electroencephalography (EEG) in cases of BCECTS has not been performed often. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-018-1228-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317234PMC
January 2019
6 Reads

Frequency and Stratification of Epileptogenic Lesions in Elderly With New Onset Seizures.

Front Neurol 2018 30;9:995. Epub 2018 Nov 30.

American University of Beirut Medical Center, Beirut, Lebanon.

To evaluate prospectively the frequency of epileptogenic lesions in a consecutive cohort of elderly patients presenting with new onset unprovoked seizures, and who underwent a complete evaluation including dedicated epilepsy protocol MRI. We included all consecutive patients 60 years or older who participated in a prospective study on new onset epilepsy. The work-up included the acquisition of a dedicated epilepsy protocol MRI and a 3 h video/EEG recording. Read More

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http://dx.doi.org/10.3389/fneur.2018.00995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284348PMC
November 2018
1 Read

Quantitative analysis and EEG markers of KCNT1 epilepsy of infancy with migrating focal seizures.

Epilepsia 2019 Jan 7;60(1):20-32. Epub 2018 Dec 7.

INSERM Unit U1129 Infantile Epilepsies and Brain Plasticity, University Paris Descartes, Sorbonne Paris Cité, Paris, France.

Objective: We aimed to characterize epilepsy of infancy with migrating focal seizures (EIMFS), a rare, severe early onset developmental epilepsy related to KCNT1 mutation, and to define specific electroencephalography (EEG) markers using EEG quantitative analysis. The ultimate goal would be to improve early diagnosis and to better understand seizure onset and propagation of EIMFS as compared to other early onset developmental epilepsy.

Methods: EEG of 7 EIMFS patients with KCNT1 mutations (115 seizures) and 17 patients with other early onset epilepsies (30 seizures) was included in this study. Read More

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http://dx.doi.org/10.1111/epi.14605DOI Listing
January 2019
2 Reads

A retrospective observational study of EEG findings and antiepileptic drug use among children referred for EEG to Zambia's University Teaching Hospital.

Epilepsia Open 2018 Dec 16;3(4):503-510. Epub 2018 Oct 16.

Epilepsy Division Department of Neurology University of Rochester Rochester New York U.S.A.

Objective: Despite the heavy burden of epilepsy in Sub-Saharan Africa, there remains a relative paucity of neurophysiology services and limited published data on electroencephalography (EEG) features among African children. The aim of this study was to describe clinical characteristics, EEG findings, and antiepileptic drug (AED) use among children referred for EEG to the University Teaching Hospital in Zambia.

Methods: EEG referrals and reports from 2013-2015 were reviewed. Read More

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http://dx.doi.org/10.1002/epi4.12267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276775PMC
December 2018
1 Read

Simultaneous scalp EEG improves seizure lateralization during unilateral intracranial EEG evaluation in temporal lobe epilepsy.

Seizure 2019 Jan 24;64:8-15. Epub 2018 Nov 24.

Department of Neurology, Baylor College of Medicine, Houston, TX 77030, United States; Neurology care line, VA Houston Medical Center, Houston, TX 77030, United States.

Purpose: To determine if simultaneous bilateral scalp EEG (scEEG) can accurately detect a contralateral seizure onset in patients with unilateral intracranial EEG (IEEG) implantation.

Methods: We evaluated 39 seizures from 9 patients with bitemporal epilepsy who underwent simultaneous scEEG and IEEG (SSIEEG). To simulate conditions of unilateral IEEG implantation with a missed contralateral seizure onset, we analyzed the IEEG recording contralateral to the seizure onset (CL- IEEG), in conjunction with simultaneous scEEG. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.11.015DOI Listing
January 2019
2 Reads

Visual field defects after radiosurgery versus temporal lobectomy for mesial temporal lobe epilepsy: Findings of the ROSE trial.

Seizure 2018 Dec 31;63:62-67. Epub 2018 Oct 31.

University of California San Diego, San Diego, CA, United States.

Purpose: Stereotactic radiosurgery (SRS) may be an alternative to anterior temporal lobectomy (ATL) for mesial temporal lobe epilepsy (MTLE). Visual field defects (VFD) occur in 9-100% of patients following open surgery for MTLE. Postoperative VFD after minimally invasive versus open surgery may differ. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183035
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http://dx.doi.org/10.1016/j.seizure.2018.10.017DOI Listing
December 2018
10 Reads

The prevalence of neural antibodies in temporal lobe epilepsy and the clinical characteristics of seropositive patients.

Seizure 2018 Dec 17;63:1-6. Epub 2018 Sep 17.

Department of Neurology, Second Faculty of Medicine, Charles University, Motol University Hospital, Czech Republic.

Purpose: Epileptic seizures are a common manifestation of autoimmune encephalitis, but the role of neural antibodies in long-term epilepsy remains unclear. The aim of this study was to assess the prevalence of neural-surface antibodies (NSAbs) and antibodies against glutamic acid decarboxylase (GAD) in patients with chronic temporal lobe epilepsy (TLE).

Method: Patients with an electro-clinical diagnosis of TLE and a disease duration longer than one year were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183005
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http://dx.doi.org/10.1016/j.seizure.2018.09.009DOI Listing
December 2018
8 Reads

Investigation of paediatric occipital epilepsy using stereo-EEG reveals a better surgical outcome than in adults, especially when the supracalcarine area is affected.

Epileptic Disord 2018 Oct;20(5):346-363

Pediatric Neurosurgery, Rothschild Foundation Hospital, Paris.

Occipital epilepsy is the least common among surgical series because: (1) the location makes it hard to asses by EEG; (2) the seizure semiology often reflects propagation; and (3) surgery entails a high risk of neurological deficits. In children, subjective symptoms are harder to assess, adding to the difficulty of a proper diagnosis. We aimed to determine electroclinical characteristics of occipital lobe epilepsy in a paediatric population by reviewing 20 children between one and 16 years, who had undergone intracranial recordings with depth electrodes. Read More

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http://dx.doi.org/10.1684/epd.2018.1000DOI Listing
October 2018
22 Reads

Ictal SPECT reveals different epileptogenic zones in frontal lobe epilepsy.

Epileptic Disord 2018 Oct;20(5):447-450

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

We report a patient with frontal lobe epilepsy due to a right frontal astrocytoma (WHO Grade III) in whom two ictal SPECTs (single photon emission tomography) were performed during two seizures with different semiology and different EEG seizure patterns. Subtraction of ictal and interictal SPECT showed right lateral frontal hyperperfusion during a left face clonic seizure, and right mesial fronto-polar hyperperfusion during a subclinical seizure. This report demonstrates that ictal SPECT may reflect different seizure semiology from the frontal lobe of the same individual and that simultaneous EEG is indispensable for the correct interpretation of SPECT in epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2018.0991DOI Listing
October 2018
9 Reads

Stimulation-induced ictal vocalisation of left frontal lobe origin.

Epileptic Disord 2018 Oct;20(5):418-422

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

Pure ictal non-speech vocalisation occurs in frontal and temporal lobe epilepsies. Electrical stimulation of supplementary motor areas is reported to evoke vocalisation in selected patients. Here, we report a patient with focal epilepsy of the left anterior insula who had isolated monotonous vocalisation elicited by electrical stimulation of the left superior frontal gyrus. Read More

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http://dx.doi.org/10.1684/epd.2018.0990DOI Listing
October 2018
11 Reads

Altered S100 Calcium-Binding Protein B and Matrix Metallopeptidase 9 as Biomarkers of Mesial Temporal Lobe Epilepsy with Hippocampus Sclerosis.

J Mol Neurosci 2018 Dec 20;66(4):482-491. Epub 2018 Oct 20.

Research on Children with Special Needs Department, National Research Centre, Giza, Egypt.

Mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) is the most common form of partial epilepsy. The aim of the present study is to highlight possible and suitable biomarkers that can help in the diagnosis and prognosis of this intractable form of epilepsy. The study was carried out on 30 epileptic patients of both sexes with complex partial seizures, having an age ranging from 4 to 30 years and were selected from the outpatient epilepsy clinic at the Kasr El-Aini Hospital in Cairo, Egypt. Read More

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http://link.springer.com/10.1007/s12031-018-1164-5
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http://dx.doi.org/10.1007/s12031-018-1164-5DOI Listing
December 2018
10 Reads
2.343 Impact Factor

Comparison of electroencephalographic findings with hippocampal magnetic resonance imaging volumetry in dogs with idiopathic epilepsy.

J Vet Intern Med 2018 Nov 16;32(6):2037-2044. Epub 2018 Oct 16.

Department of Internal Medicine and Clinic for Horses, Dogs and Cats, The Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.

Background: In humans, temporal lobe epilepsy (TLE), is a type of focal epilepsy occurring mainly in the mesial TLE (mTLE), commonly associated with hippocampal sclerosis (HS).

Objectives: According to recent studies, TLE might also occur in dogs and could be associated with hippocampal atrophy (HA)/HS. To date, hippocampal lesions have not been correlated with electroencephalographic (EEG) findings in epileptic dogs. Read More

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http://dx.doi.org/10.1111/jvim.15323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271325PMC
November 2018
2 Reads

Efficacy of levetiracetam for reducing rolandic discharges in comparison with carbamazepine and valproate sodium in rolandic epilepsy.

Seizure 2018 Nov 3;62:79-83. Epub 2018 Oct 3.

Graduate Faculty of Interdisciplinary Research, Graduate School, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.

Purpose: The main purpose of this study was to compare the efficacy of levetiracetam (LEV) with the older antiepileptic drugs (AEDs) for preventing atypical evolution in children with Rolandic epilepsy (RE). Accordingly, the present study compared the efficacy of older AEDs (carbamazepine (CBZ) and valproate sodium (VPA)) with LEV in reducing rolandic discharges (RDs) on interictal electroencephalogram (EEG) in children with RE.

Methods: Patients in this heterogenous study were subdivided into CBZ, VPA and LEV groups in accordance with the initial monotherapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183024
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http://dx.doi.org/10.1016/j.seizure.2018.10.002DOI Listing
November 2018
1 Read

Intracranial Electrode Placement for Seizures Before Temporal Lobectomy: A Risk-Benefit Analysis.

World Neurosurg 2019 Jan 25;121:e215-e222. Epub 2018 Sep 25.

Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address:

Background And Objective: Anterior temporal lobectomy (ATL) is the most common surgical procedure for refractory temporal lobe epilepsy. When scalp electroencephalography cannot adequately identify an epileptogenic site, electrode implantation may be used to monitor epileptic activity and localize a target focus before surgical resection. Whether the advantage of improved seizure localization justifies the added risk of electrode placement remains unclear. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.079DOI Listing
January 2019
2 Reads

Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology.

Acta Neurol Scand 2018 Dec 19;138(6):475-481. Epub 2018 Sep 19.

Department of Pediatric Neurology, Developmental Medicine and Social Pediatrics, University of Munich, Munich, Germany.

Objectives: Neuropsychological sequelae are a feature of benign epilepsy with centrotemporal spikes (BECTS) in children. A correlation between the frequency of interictal EEG discharges and the cognitive as well as behavioral profile of the patients has been suspected but not proven.

Materials And Methods: Children with BECTS that had not yet been treated were included into a randomized controlled trial. Read More

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http://dx.doi.org/10.1111/ane.13015DOI Listing
December 2018

Use of Subtemporal Electrode Chains and Their Contribution to Presurgical Evaluation.

Neurodiagn J 2018 ;58(3):164-173

a Neurodiagnostic Laboratory Duke University Medical Center , Durham , North Carolina.

Subtemporal electrode chains are part of the international 10-10 system. Since 2012, they have been routinely used at our institution in adult patients with intractable epilepsy who are undergoing video EEG evaluation for epilepsy surgery. In 2016, this was extended to the pediatric population. Read More

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http://dx.doi.org/10.1080/21646821.2018.1491173DOI Listing
November 2018
1 Read

Putting it all together: Options for intractable epilepsy: An updated algorithm on the use of epilepsy surgery and neurostimulation.

Epilepsy Behav 2018 Nov 18;88S:33-38. Epub 2018 Sep 18.

University of South Florida, Tampa, FL, United States.

For drug-resistant epilepsy, nonpharmacologic treatments should be considered early rather than late. Of the nondrug treatments, only resective surgery can be curative. Neurostimulation is palliative, i. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.05.030DOI Listing
November 2018
6 Reads

Parasomnia versus epilepsy: An affair of the heart?

Neurophysiol Clin 2018 Oct 15;48(5):277-286. Epub 2018 Sep 15.

NeuroPain Team, Inserm U 1028/CNRS, UMR 5292, University of Lyon, Lyon Neuroscience Research Centre (CRNL), 69677 Bron, France.

Objective: Differential diagnosis between sleep-related epileptic seizures and NREM parasomnia remains challenging. Pathophysiological markers to differentiate both conditions are needed. Activation of autonomic system is present in arousal reactions and epileptic seizures. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.08.002DOI Listing
October 2018
4 Reads

Ictal Asystole Induced by Right Posterior Quadrant Epilepsy: Report of a Radically Treated Case.

World Neurosurg 2018 Dec 14;120:337-342. Epub 2018 Sep 14.

Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Shizuoka, Japan.

Background: Ictal asystole (IA) and ictal bradycardia (IB) are mainly seen with temporal or frontal lobe epilepsy. Many patients with these conditions undergo cardiac pacemaker therapy but not epilepsy surgery.

Case Description: We report the case of a 15-year-old boy with IA and IB secondary to right posterior quadrant epilepsy (PoQE) who underwent right posterior quadrant disconnection, but not cardiac pacemaker implantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183207
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http://dx.doi.org/10.1016/j.wneu.2018.09.030DOI Listing
December 2018
6 Reads

Prognostic Factors and Longitudinal Change in Long-Term Outcome of Frontal Lobe Epilepsy Surgery.

World Neurosurg 2019 Jan 3;121:e32-e38. Epub 2018 Sep 3.

Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objective: We aimed to investigate the possible predictive factors and longitudinal change in long-term surgical outcome after refractory frontal lobe epilepsy surgery.

Methods: We retrospectively reviewed 82 patients who underwent frontal lobe resection. Invasive monitoring was performed in 43 patients. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.192DOI Listing
January 2019
12 Reads

The Comorbidity of Focal Epilepsy and Narcolepsy Type 1 - Two Case Reports.

Neuro Endocrinol Lett 2018 05;39(2):95-98

1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

The aim of this study is to remind the possibility of co-occurrence of epilepsy and narcolepsy. In the first case report, narcolepsy type 1 was diagnosed in 29-year-old female. After one year of the treatment with modafinil a new episodes of automatic behavior appeared. Read More

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May 2018
5 Reads

The Imaging of Localization Related Symptomatic Epilepsies: The Value of Arterial Spin Labelling Based Magnetic Resonance Perfusion.

Korean J Radiol 2018 Sep-Oct;19(5):965-977. Epub 2018 Aug 6.

Department of Imaging Sciences & Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Trivandrum 695011, India.

Accurate identification of the epileptogenic zone is an important prerequisite in presurgical evaluation of refractory epilepsy since it affects seizure-free outcomes. Apart from structural magnetic resonance imaging (sMRI), delineation has been traditionally done with electroencephalography and nuclear imaging modalities. Arterial spin labelling (ASL) sequence is a non-contrast magnetic resonance perfusion technique capable of providing similar information. Read More

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http://dx.doi.org/10.3348/kjr.2018.19.5.965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082755PMC
August 2018
6 Reads

Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy.

Neuroimage Clin 2018 30;20:71-84. Epub 2018 Jun 30.

Multimodal Functional Imaging Lab, Department of Biomedical Engineering, McGill University, Duff Medical Building, 3775 Rue University, Montreal, QC H3A 2B4, Canada; Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada; Centre de Recherches Mathématiques, Université de Montréal, Pavillon André-Aisenstadt 2920 Chemin de la tour, Montreal, QC H3T 1J4, Canada; Department of Physics and PERFORM Centre, Concordia University, 7200 Rue Sherbrooke St. W, Montreal, QC H4B 1R6, Canada.

Hubs of brain networks are brain regions exhibiting denser connections than others, promoting long-range communication. Studies suggested the reorganization of hubs in epilepsy. The patterns of connector hub abnormalities specific to mesial temporal lobe epilepsy (mTLE) are unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183021
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http://dx.doi.org/10.1016/j.nicl.2018.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070692PMC
January 2019
14 Reads

[A case of painful seizure accompanying ictal paresis and homonymous hemianopia due to post-stroke epilepsy].

Rinsho Shinkeigaku 2018 Aug 31;58(8):492-498. Epub 2018 Jul 31.

Department of Neurology, Tenri Hospital.

A 69-year-old female with an old infarct of the left parietotemporal lobe was admitted for the evaluation of suspected painful seizures accompanying ictal paresis. The painful seizure and ictal paresis involved her right extremities without convulsions, although intermittent tremulous movements were noted on the right upper extremity. She also showed right hemianopia during the seizure. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001167DOI Listing
August 2018
2 Reads

[A case series of 4 epilepsy patients with promnesia].

Rinsho Shinkeigaku 2018 Aug 31;58(8):513-516. Epub 2018 Jul 31.

Department of Neurology, Kyoto University Graduate School of Medicine.

Promnesia is a feeling of familiarity and foreknowledge and is a manifestation of simple partial seizures (focal aware seizures). It is similar to déjà vu and has been reported to be a rare symptom in patients with temporal lobe epilepsy. Here, we investigated the clinical characteristics in 4 patients with partial epilepsy presenting promnesia. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001149DOI Listing
August 2018
3 Reads

Data mining MR image features of select structures for lateralization of mesial temporal lobe epilepsy.

PLoS One 2018 1;13(8):e0199137. Epub 2018 Aug 1.

Radiology and Research Administration, Henry Ford Health System, Detroit, Michigan, United States of America.

Purpose: This study systematically investigates the predictive power of volumetric imaging feature sets extracted from select neuroanatomical sites in lateralizing the epileptogenic focus in mesial temporal lobe epilepsy (mTLE) patients.

Methods: A cohort of 68 unilateral mTLE patients who had achieved an Engel class I outcome postsurgically was studied retrospectively. The volumes of multiple brain structures were extracted from preoperative magnetic resonance (MR) images in each. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199137PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070173PMC
January 2019
4 Reads

Dyshormia in focal epilepsy.

Arq Neuropsiquiatr 2018 Jul;76(7):495-496

University of Kentucky Department of Neurology, Lexington, KY, USA.

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http://dx.doi.org/10.1590/0004-282X20180045DOI Listing
July 2018
3 Reads

"Time is Brain"-How early should surgery be done in drug-resistant TLE?

Acta Neurol Scand 2018 Dec 21;138(6):531-540. Epub 2018 Aug 21.

R. Madhavan Nayar Center for Comprehensive Epilepsy Care, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

Objectives: To explore the effect of duration of epilepsy and delay in surgery on seizure outcome in patients operated for drug-resistant temporal lobe epilepsy (TLE).

Materials & Methods: A total of 664 consecutive patients who underwent anterior temporal lobectomy (ATL) for TLE from 1995 to 2008 formed the study cohort. We divided them into two, one as seizure-free with or without antiepileptic drugs after ATL as "good outcome" (Engel class I a) and seizures of any type, any time after surgery as "poor outcome. Read More

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http://dx.doi.org/10.1111/ane.13008DOI Listing
December 2018
18 Reads

Hippocampal Transection Plus Tumor Resection as a Novel Surgical Treatment for Temporal Lobe Epilepsy Associated with Cerebral Cavernous Malformations.

World Neurosurg 2018 Nov 29;119:e209-e215. Epub 2018 Jul 29.

Department of Neurosurgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Objective: The optimal surgical treatment for cavernous malformation-related temporal lobe epilepsy (CRTLE) is still controversial because it frequently involves the hippocampus as an epileptogenic zone. Here we describe our unique surgical strategy of performing hippocampal transection (HT) plus tumor resection for CRTLE to solve the question of how to balance postoperative seizure outcomes and neuropsychologic outcomes.

Methods: From 2005 to 2016, 7 cases of HT (3 on dominant side) plus tumor resection were performed for patients with CRTLE. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.108DOI Listing
November 2018

A triad of infantile spasms, nystagmus and a focal tonic seizure.

Epileptic Disord 2018 Aug;20(4):295-300

Pediatric Neurology Unit, University Hospitals Geneva, Switzerland.

Epileptic spasms represent a subcategory of motor seizures that have been extensively documented and recently re-classified by the International League Against Epilepsy as either generalized, focal or of unknown onset. Atypical characteristics continue to be reported in case studies, emphasizing the divergent morphological traits and putting into question the underlying aetiopathophysiology. Here, we report the findings of an infant with a triad of clinical manifestations during a single ictal event, comprising a cluster of epileptic spasms, vertical binocular nystagmus, and a focal tonic seizure. Read More

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http://dx.doi.org/10.1684/epd.2018.0984DOI Listing
August 2018
7 Reads

Machine learning detects EEG microstate alterations in patients living with temporal lobe epilepsy.

Seizure 2018 Oct 10;61:8-13. Epub 2018 Jul 10.

Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka 560029, India; Advanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka 560029, India. Electronic address:

Purpose: Quasi-stable electrical distribution in EEG called microstates could carry useful information on the dynamics of large scale brain networks. Using machine learning techniques we explored if abnormalities in microstates can identify patients with Temporal Lobe Epilepsy (TLE) in the absence of an interictal discharge (IED).

Method: 4 Classes of microstates were computed from 2 min artefact free EEG epochs in 42 subjects (21 TLE and 21 controls). Read More

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http://dx.doi.org/10.1016/j.seizure.2018.07.007DOI Listing
October 2018
3 Reads
2.060 Impact Factor

Selective visual representation of letters and words in the left ventral occipito-temporal cortex with intracerebral recordings.

Proc Natl Acad Sci U S A 2018 08 23;115(32):E7595-E7604. Epub 2018 Jul 23.

Psychological Sciences Research Institute, UCLouvain, B-1348 Louvain-La-Neuve, Belgium.

We report a comprehensive cartography of selective responses to visual letters and words in the human ventral occipito-temporal cortex (VOTC) with direct neural recordings, clarifying key aspects of the neural basis of reading. Intracerebral recordings were performed in a large group of patients ( = 37) presented with visual words inserted periodically in rapid sequences of pseudofonts, nonwords, or pseudowords, enabling classification of responses at three levels of word processing: letter, prelexical, and lexical. While letter-selective responses are found in much of the VOTC, with a higher proportion in left posterior regions, prelexical/lexical responses are confined to the middle and anterior sections of the left fusiform gyrus. Read More

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http://dx.doi.org/10.1073/pnas.1718987115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094145PMC
August 2018
5 Reads

Probabilistic functional tractography of the human cortex revisited.

Neuroimage 2018 11 17;181:414-429. Epub 2018 Jul 17.

Inserm, U1216, Grenoble, F-38000, France; Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, F-38000, France. Electronic address:

In patients with pharmaco-resistant focal epilepsies investigated with intracranial electroencephalography (iEEG), direct electrical stimulations of a cortical region induce cortico-cortical evoked potentials (CCEP) in distant cerebral cortex, which properties can be used to infer large scale brain connectivity. In 2013, we proposed a new probabilistic functional tractography methodology to study human brain connectivity. We have now been revisiting this method in the F-TRACT project (f-tract. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2018.07.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150949PMC
November 2018
13 Reads

Quantitative and qualitative analysis of ictal vocalization in focal epilepsy syndromes.

Seizure 2018 Aug 11;60:178-183. Epub 2018 Jul 11.

Epilepsy Center, Department of Neurology, University Hospital, LMU Munich, Munich, Germany.

Purpose: To investigate the frequency, localizing significance, and intensity characteristics of ictal vocalization in different focal epilepsy syndromes.

Methods: Up to four consecutive focal seizures were evaluated in 277 patients with lesional focal epilepsy, excluding isolated auras and subclinical EEG seizure patterns. Vocalization was considered to be present if observed in at least one of the analyzed seizures and not being of speech quality. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.07.008DOI Listing
August 2018
12 Reads

Unilateral temporal interictal epileptiform discharges correctly predict the epileptogenic zone in lesional temporal lobe epilepsy.

Epilepsia 2018 08 15;59(8):1577-1582. Epub 2018 Jul 15.

Epilepsy Center, Department of Neurology, University Hospital, Ludwig-Maximilians-University, Munich, Germany.

Objective: To evaluate the necessity of recording ictal electroencephalography (EEG) in patients with temporal lobe epilepsy (TLE) considered for resective surgery who have unilateral temporal interictal epileptiform discharges (IEDs) and concordant ipsitemporal magnetic resonance imaging (MRI) pathology. To calculate the necessary number of recorded EEG seizure patterns (ESPs) to achieve adequate lateralization probability.

Methods: In a retrospective analysis, the localization and lateralization of interictal and ictal EEG of 304 patients with lesional TLE were analyzed. Read More

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http://dx.doi.org/10.1111/epi.14514DOI Listing
August 2018
6 Reads

Cortical morphology, epileptiform discharges, and neuropsychological performance in BECTS.

Acta Neurol Scand 2018 Nov 10;138(5):432-440. Epub 2018 Jul 10.

Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objectives: The aim of this study was to understand the relationship between cortical morphology, centrotemporal spike (CTS), and neuropsychological functioning in children with BECTS compared to their typically developing peers.

Materials And Methods: To examine whole-brain differences in cortical thickness between groups, a general linear model approach was applied to T1-weighted structural magnetic resonance imaging (MRI) in children with BECTS and typically developing children. Further region-of-interest (ROI) analyses were performed to examine the effects of frequency and lateralization of CTS. Read More

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http://dx.doi.org/10.1111/ane.12997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175642PMC
November 2018
7 Reads

SEEG-guided radiofrequency coagulation (SEEG-guided RF-TC) versus anterior temporal lobectomy (ATL) in temporal lobe epilepsy.

J Neurol 2018 Sep 26;265(9):1998-2004. Epub 2018 Jun 26.

Department of Neurosurgery, Hospices Civils de Lyon, Neurology and Neurosurgery Hospital Pierre Wertheimer, 59, Bd Pinel, 69677, Bron, France.

Background: Stereoelectroencephalography-guided radiofrequency thermocoagulation (SEEG-guided RF-TC) is a super-selective procedure. Hippocampus has a limited volume and is widely accessible to SEEG so that SEEG-guided RF-TC could be an alternative to the anterior temporal lobectomy (ATL) in case of temporal lobe epilepsy (TLE) syndrome.

Objective: To compare seizure-free rate at 1-year follow-up between patients undergoing SEEG-guided RF-TC and patients undergoing ATL in TLE over a 15-year period. Read More

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http://dx.doi.org/10.1007/s00415-018-8958-9DOI Listing
September 2018
22 Reads

Detection of Lesions in Mesial Temporal Lobe Epilepsy by Using MR Fingerprinting.

Radiology 2018 09 19;288(3):804-812. Epub 2018 Jun 19.

From the Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science (C.L., X.C., Y.L., H.Y., Q.D., H.H., J.Z.), Department of Neurology, The First Affiliated Hospital (K.W., D.W.), State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering (H.Y.), and Center for Innovative and Collaborative Detection and Treatment of Infectious Diseases (J.Z.), Zhejiang University, 38 Zheda Rd, Hangzhou, Zhejiang 310027, China; and the Department of Imaging Sciences, University of Rochester, Rochester, NY (J.Z.).

Purpose To improve diagnosis of hippocampal sclerosis (HS) in patients with mesial temporal lobe epilepsy (MTLE) by using MR fingerprinting and compare with visual assessment of T1- and T2-weighted MR images. Materials and Methods For this prospective study performed between April and November 2016, T1 and T2 maps were obtained and tissue segmentation performed in consecutive patients with drug-resistant MTLE with unilateral or bilateral HS. T1 and T2 maps were compared between 33 patients with MTLE (23 women and 10 men; mean age, 32. Read More

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http://dx.doi.org/10.1148/radiol.2018172131DOI Listing
September 2018
3 Reads

The phenotype of bilateral hippocampal sclerosis and its management in "real life" clinical settings.

Epilepsia 2018 07 14;59(7):1410-1420. Epub 2018 Jun 14.

FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.

Objective: There is little detailed phenotypic characterization of bilateral hippocampal sclerosis (HS). We therefore conducted a multicenter review of people with pharmacoresistant epilepsy and bilateral HS to better determine their clinical characteristics.

Methods: Databases from 11 EPIGEN centers were searched. Read More

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http://dx.doi.org/10.1111/epi.14436DOI Listing
July 2018
4 Reads

Ictal and preictal power changes outside of the seizure focus correlate with seizure generalization.

Epilepsia 2018 07 13;59(7):1398-1409. Epub 2018 Jun 13.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Objective: The treatment of focal epilepsies is largely predicated on the concept that there is a "focus" from which the seizure emanates. Yet, the physiological context that determines if and how ictal activity starts and propagates remains poorly understood. To delineate these phenomena more completely, we studied activity outside the seizure-onset zone prior to and during seizure initiation. Read More

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http://dx.doi.org/10.1111/epi.14449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031475PMC
July 2018
3 Reads
4.571 Impact Factor

Electroencephalographic and Electrocardiographic Effect of Intravenous Lacosamide in Refractory Focal Epilepsy.

J Clin Neurophysiol 2018 Sep;35(5):365-369

Department of Clinical Neurological Sciences, Western University, London, ON, Canada.

Purpose: Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels to achieve seizure reduction. We studied the effect of intravenous lacosamide given as one of three single doses on EEG and electrocardiogram, as well as its tolerability in patients with drug-resistant epilepsy.

Methods: This Canadian, investigator-initiated, multicenter, double-blind study recruited patients with refractory focal epilepsy admitted to a seizure monitoring unit. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000479DOI Listing
September 2018

Dynamic Preictal Discharges in Patients With Mesial Temporal Lobe Epilepsy.

J Clin Neurophysiol 2018 Sep;35(5):381-387

Department of Neurology, Beijing Key Laboratory of Neuromodulation, Xuanwu Hospital, Capital Medical University, Beijing, China.

Purpose: It has been challenging to detect early changes preceding seizure onset in patients with epilepsy. This study investigated the preictal discharges (PIDs) by intracranial electroencephalogram of 11 seizures from 7 patients with mesial temporal lobe epilepsy.

Methods: The EEG segments consisting of 30 seconds before ictal onset and 5 seconds after ictal onset were selected for analysis. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000486DOI Listing
September 2018
19 Reads

Consecutive occurrence of benign epilepsy with centro-temporal spike and childhood absence epilepsy: true coexistence or atypical evolution?

World J Pediatr 2018 08 22;14(4):410-411. Epub 2018 May 22.

Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea.

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http://dx.doi.org/10.1007/s12519-018-0148-4DOI Listing
August 2018
13 Reads

Spike persistence and normalization in benign epilepsy with centrotemporal spikes - Implications for management.

Brain Dev 2018 Sep 10;40(8):693-698. Epub 2018 May 10.

Pediatric Regional Epilepsy Center, Children's Hospital of Philadelphia, Philadelphia, PA, United States; Department of Neurology, Perelman School of Medicine, University of Philadelphia, Philadelphia, PA, United States.

Purpose: This study was performed 1) to determine the timing of spike normalization in patients with benign epilepsy with centrotemporal spikes (BECTS); 2) to identify relationships between age of seizure onset, age of spike normalization, years of spike persistence and treatment; and 3) to assess final outcomes between groups of patients with or without spikes at the time of medication tapering.

Methods: Retrospective analysis of BECTS patients confirmed by clinical data, including age of onset, seizure semiology and serial electroencephalography (EEG) from diagnosis to remission. Age at spike normalization, years of spike persistence, and time of treatment onset to spike normalization were assessed. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.04.011DOI Listing
September 2018
8 Reads

Severe neonatal hyperbilirubinemia induces temporal and occipital lobe seizures.

Authors:
Lian Zhang

PLoS One 2018 11;13(5):e0197113. Epub 2018 May 11.

Department of Neonatology, Shenzhen City Baoan District Women and Children's Hospital, Shenzhen, People's Republic of China.

To examine the origin of seizures induced by severe neonatal hyperbilirubinemia, The EEG characteristics of seizures were analyzed in newborns with and without severe neonatal hyperbilirubinemia. Fisher's exact test was used to determine the specificity. In total, 931 patients had a total serum bilirubin (TSB) level of 340-425 μmol/L, only 2 of whom had seizures. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197113PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947905PMC
July 2018
4 Reads

Early identification of epileptic encephalopathy with continuous spikes-and-waves during sleep: A case-control study.

Eur J Paediatr Neurol 2018 Sep 27;22(5):837-844. Epub 2018 Apr 27.

AP-HP, Hôpital Robert Debré, Service de Neurologie Pédiatrique, 75019, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR1141, 75019, Paris, France. Electronic address:

Epileptic encephalopathy with continuous spikes-and-waves during sleep (EE-CSWS) is a rare childhood epilepsy syndrome characterized by a regression in cognitive, behavioral and psychiatric functioning, seizures and a specific electroencephalographic pattern. An early recognition and an appropriate treatment might play a key role in the outcome of this epileptic encephalopathy. We conducted a case-control study to evaluate if there is any clinical or electroencephalographic sign suggestive of EE-CSWS after the first seizure. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.04.009DOI Listing
September 2018
5 Reads

Increased cardiac stiffness is associated with autonomic dysfunction in patients with temporal lobe epilepsy.

Epilepsia 2018 06 26;59(6):e85-e90. Epub 2018 Apr 26.

Medical Sciences Postgraduate Program, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil.

Autonomic dysfunction is linked to sudden death regardless of the presence of structural heart disease. The pathway from autonomic dysfunction to sudden death is not fully understood, but myocardial sympathetic stimulation leading to arrhythmia and/or cardiac fibrosis might play a role. Our goal was to evaluate cardiac stiffness by echocardiography and its association with clinical, structural, and autonomic variables in people with epilepsy (PWE) compared to healthy controls. Read More

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http://doi.wiley.com/10.1111/epi.14084
Publisher Site
http://dx.doi.org/10.1111/epi.14084DOI Listing
June 2018
1 Read