Neurology 2022 05 25;98(20):e2060-e2072. Epub 2022 Mar 25.
From the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.
Background And Objectives: Functional connectivity (FC) measures can be used to differentiate epileptogenic zones (EZs) from non-EZs in patients with medically refractory epilepsy. Little work has been done to evaluate the stability of stereo-EEG (SEEG) FC measures over time and their relationship with antiseizure medication (ASM) use, a critical confounder in epilepsy FC studies. We aimed to answer the following questions: Are SEEG FC measures stable over time? Are they influenced by ASMs? Are they affected by patient data collection state?
Methods: In 32 patients with medically refractory focal epilepsy, we collected a single 2-minute prospective SEEG resting-state (awake, eyes closed) data set and consecutive 2-minute retrospective pseudo-rest (awake, eyes open) data sets for days 1-7 postimplantation. Read More