11,329 results match your criteria Localization-related Epilepsies on EEG


Harefuah 2022 Jun;161(6):349-354

The Multidisciplinary Center for Functional Neurosurgery, Assuta Medical Centers , Tel Aviv, Israel.

Introduction: About one percent (over 81,000 patients) of the Israeli population suffer from epilepsy. The main treatment for this condition is medication, but about a third of the patients suffer from drug-resistant epilepsy (DRE). Each year about 5,000 new patients are diagnosed with epilepsy, of whom 3,000 are children. Read More

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Face-induced gamma oscillations and event-related potentials in patients with epilepsy: an intracranial EEG study.

BMC Neurosci 2022 Jun 13;23(1):36. Epub 2022 Jun 13.

Epilepsy Center Hamburg, Protestant Hospital Alsterdorf, Hamburg, Germany.

Background: To examine the pathological effect of a mesial temporal seizure onset zone (SOZ) on local and inter-regional response to faces in the amygdala and other structures of the temporal lobe.

Methods: Intracranial EEG data was obtained from the amygdala, hippocampus, fusiform gyrus and parahippocampal gyrus of nine patients with drug-refractory epilepsy during visual stimulation with faces and mosaics. We analyzed event-related potentials (ERP), gamma frequency power, phase-amplitude coupling and phase-slope-index and compared the results between patients with versus without a mesial temporal SOZ. Read More

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Stereoelectroencephalography in the preoperative assessment of patients with refractory focal epilepsy: experience at an epilepsy centre.

Neurologia (Engl Ed) 2022 Jun 25;37(5):334-345. Epub 2021 May 25.

Programa de Epilepsia, Servicio de Neurología, Hospital Ruber Internacional, Madrid, Spain.

Objective: Stereoelectroencephalography (SEEG) is a technique for preoperative evaluation of patients with difficult-to-localise refractory focal epilepsy (DLRFE), enabling the study of deep cortical structures. The procedure, which is increasingly used in international epilepsy centres, has not been fully developed in Spain. We describe our experience with SEEG in the preoperative evaluation of DLRFE. Read More

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Mental disorders as an indication for surgical treatment of drug-resistant temporal lobe epilepsy.

Prog Brain Res 2022 18;272(1):125-141. Epub 2022 May 18.

Sverdlovsk Regional Clinical Neuropsychiatric Hospital for War Veterans, Yekaterinburg, Russia.

This study recruited 82 patients with temporal lobe epilepsy (TLE): 41 men and 41 women, who underwent an open epilepsy surgery to remove the epileptic focus from 1963 to 1970. The patients before surgery were divided into two groups: group I included 49 patients with minor mental disorders and group II included 33 patients with major mental disorders. Features of mental disorders in patients with monotemporal lobe epilepsy were identified. Read More

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Drug-resistant epilepsy at the age extremes: Disentangling the underlying etiology.

Epilepsy Behav 2022 Jul 25;132:108739. Epub 2022 May 25.

Regional Health Agency of Tuscany, Firenze, Italy.

The incidence of epilepsy is highest at the extreme age ranges: childhood and elderly age. The most common syndromes in these demographics - self-limited epilepsies of childhood and idiopathic generalized epilepsies in pediatric age, focal epilepsy with structural etiology in older people - are expected to be drug responsive. In this work, we focus on such epilepsy types, overviewing the complex clinical background of unexpected drug-resistance. Read More

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Epileptic encephalopathy with electrical status epilepticus during slow sleep: evaluation of treatment response from a tertiary center.

Turk J Pediatr 2022 ;64(2):302-311

Department of Pediatric Neurology, İstanbul Medipol University Faculty of Medicine, İstanbul, Turkey.

Background: This study aimed to evaluate the clinical, electrophysiological, etiological features, and treatment response in children with epileptic encephalopathy with electrical status epilepticus during slow sleep (ESES).

Methods: Clinical data, records of electroencephalograms (EEG), and brain magnetic resonance imaging (MRI) findings of 33 patients with ESES who were treated, and followed up for at least one year were retrospectively analyzed.

Results: Of all patients, 57. Read More

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Whole exome sequencing and co-expression analysis identify an SCN1A variant that modifies pathogenicity in a family with genetic epilepsy and febrile seizures plus.

Epilepsia 2022 May 20. Epub 2022 May 20.

Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA.

Objective: Family members carrying the same SCN1A variant often exhibit differences in the clinical severity of epilepsy. This variable expressivity suggests that other factors aside from the primary sodium channel variant influence the clinical manifestation. However, identifying such factors has proven challenging in humans. Read More

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Intra- and Inter-Subject Perspectives on the Detection of Focal Onset Motor Seizures in Epilepsy Patients.

Sensors (Basel) 2022 Apr 26;22(9). Epub 2022 Apr 26.

Epilepsy Center, Department of Neurosurgery, Medical Center-University of Freiburg, 79106 Freiburg im Breisgau, Germany.

Focal onset epileptic seizures are highly heterogeneous in their clinical manifestations, and a robust seizure detection across patient cohorts has to date not been achieved. Here, we assess and discuss the potential of supervised machine learning models for the detection of focal onset motor seizures by means of a wrist-worn wearable device, both in a personalized context as well as across patients. Wearable data were recorded in-hospital from patients with epilepsy at two epilepsy centers. Read More

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SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility.

Acta Neuropathol 2022 Jul 12;144(1):107-127. Epub 2022 May 12.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, Box 29, Queen Square, London, WC1N 3BG, UK.

Mesial temporal lobe epilepsy with hippocampal sclerosis and a history of febrile seizures is associated with common variation at rs7587026, located in the promoter region of SCN1A. We sought to explore possible underlying mechanisms. SCN1A expression was analysed in hippocampal biopsy specimens of individuals with mesial temporal lobe epilepsy with hippocampal sclerosis who underwent surgical treatment, and hippocampal neuronal cell loss was quantitatively assessed using immunohistochemistry. Read More

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Profiles of indigenous patients with epilepsy in a Brazilian village.

Epilepsy Behav 2022 06 5;131(Pt A):108703. Epub 2022 May 5.

Department of Neuroscience and Behavioral Science, Division of Neurology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.

Introduction: Identifying epilepsy in local indigenous populations and describing its epidemiological, etiological, electroencephalographic, and therapeutic aspects can assist public health policies planning toward epilepsy in indigenous communities.

Methods: This descriptive, cross-sectional study investigated epilepsy among indigenous people residing in Jaguapirú Village, Dourados, Mato Grosso do Sul, Brazil. Participants had their clinical histories reviewed and physical examination performed, as well as one or more electroencephalograms (EEG) registered. Read More

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International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions.

Epilepsia 2022 06 3;63(6):1398-1442. Epub 2022 May 3.

Robert Debré Hospital, Public Hospital Network of Paris, NeuroDiderot, National Institute of Health and Medical Research, Department Medico-Universitaire Innovation Robert-Debré, Pediatric Neurology, University of Paris, Paris, France.

The 2017 International League Against Epilepsy classification has defined a three-tier system with epilepsy syndrome identification at the third level. Although a syndrome cannot be determined in all children with epilepsy, identification of a specific syndrome provides guidance on management and prognosis. In this paper, we describe the childhood onset epilepsy syndromes, most of which have both mandatory seizure type(s) and interictal electroencephalographic (EEG) features. Read More

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Noninvasive Detection of Hippocampal Epileptiform Activity on Scalp Electroencephalogram.

JAMA Neurol 2022 Jun;79(6):614-622

Department of Neurology, Massachusetts General Hospital, Boston.

Importance: The hippocampus is a highly epileptogenic brain region, yet over 90% of hippocampal epileptiform activity (HEA) cannot be identified on scalp electroencephalogram (EEG) by human experts. Currently, detection of HEA requires intracranial electrodes, which limits our understanding of the role of HEA in brain diseases.

Objective: To develop and validate a machine learning algorithm that accurately detects HEA from a standard scalp EEG, without the need for intracranial electrodes. Read More

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Epileptiform GluN2B-driven excitation in hippocampus as a therapeutic target against temporal lobe epilepsy.

Exp Neurol 2022 Aug 22;354:114087. Epub 2022 Apr 22.

Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteur Street 3, 02-093 Warsaw, Poland. Electronic address:

GluN2B is an NMDAR subunit that displays restricted expression in the mature hippocampus - a structure playing a major role in temporal lobe epilepsy. However, the contribution of GluN2B to the pathophysiology of the condition has not been fully explored. Here we combined status epilepticus models of temporal lobe epilepsy, protein expression studies, and patch-clamp experiments to demonstrate the profound change in the nature of glutamatergic transmission mediated in the epileptiform hippocampus by a subpopulation of GluN2B-containing NMDAR receptors. Read More

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Epilepsy Surgery in Extratemporal vs Temporal Lobe Epilepsy: Changes in Surgical Volumes and Seizure Outcome Between 1990 and 2017.

Neurology 2022 05 15;98(19):e1902-e1912. Epub 2022 Apr 15.

From the Society for Epilepsy Research (A.H., C.G.B.); and Departments of Epileptology (Krankenhaus Mara) (C.G.B., J.L.H., P.G.) and Neurosurgery (Evangelisches Klinikum Bethel) (T.K.), Medical School, Bielefeld University, Germany.

Background And Objectives: Seizure outcome after extratemporal lobe epilepsy (exTLE) surgery has often been poorer than after temporal lobe epilepsy (TLE) surgery, but recent improvements in diagnostics and surgery may have changed this. Our aim was to analyze the changes in presurgical and surgical volumes and seizure outcome 2 years after surgery for patients with exTLE compared with those with TLE.

Methods: We performed a retrospective, single-center cohort study including patients from the Bethel presurgical-surgical-postsurgical database from 1990 to 2017. Read More

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Repetitive transcranial magnetic stimulation to treat benign epilepsy with centrotemporal spikes.

Brain Stimul 2022 May-Jun;15(3):601-604. Epub 2022 Apr 12.

Department of Neurology, Xuanwu Hospital, Clinical Center for Epilepsy, Capital Medical University, Chinese Institute for Brain Disorders, Beijing, China. Electronic address:

Objectives: To investigate the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on patients with benign epilepsy with centrotemporal spikes (BECTS).

Methods: In this open pilot study, we enrolled four BECTS patients who had frequent seizures (at least 3 seizures during the 3-month baseline). After localizing sources of interictal epileptiform discharges (IEDs) with magnetoencephalography, IEDs-source-rTMS (1 Hz) with 500 pulses at 90% of resting motor threshold was applied for 10 weekdays in each patient. Read More

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A descriptive study of eye and head movements in versive seizures.

Seizure 2022 May 8;98:44-50. Epub 2022 Apr 8.

Department of Neurology, University Hospitals Cleveland Medical Center and Case Western Reserve University, 11100 Euclid Ave, Lksd #3200, Cleveland, OH 44106, USA.

Background: Versive seizures, consisting of forced, involuntary, sustained and unnatural turning of eyes and head toward one side, lateralize to the hemisphere contralateral to the direction of the eye and head turn. The characteristics of eye and head movements in version have been rarely and incompletely studied in spontaneous epileptic seizures as opposed to direct cortical stimulation studies.

Methods: We performed a single center retrospective analysis of a cohort of 28 patients with 43 seizures, who had been admitted to the adult epilepsy monitoring unit at University Hospitals Cleveland Medical Center between January 2009 and August 2020. Read More

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Genetic Epilepsy Syndromes.

Kenneth A Myers

Continuum (Minneap Minn) 2022 04;28(2):339-362

Purpose Of Review: This article reviews the clinical features, typical EEG findings, treatment, prognosis, and underlying molecular etiologies of the more common genetic epilepsy syndromes. Genetic generalized epilepsy, self-limited focal epilepsy of childhood, self-limited neonatal and infantile epilepsy, select developmental and epileptic encephalopathies, progressive myoclonus epilepsies, sleep-related hypermotor epilepsy, photosensitive occipital lobe epilepsy, and focal epilepsy with auditory features are discussed. Also reviewed are two familial epilepsy syndromes: genetic epilepsy with febrile seizures plus and familial focal epilepsy with variable foci. Read More

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Automatic seizure detection and seizure pattern morphology.

Clin Neurophysiol 2022 06 18;138:214-220. Epub 2022 Mar 18.

Department of Neurology, Clinic Hietzing, Vienna, Austria; Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, Vienna, Austria; Medical Faculty, Sigmund Freud University, Vienna, Austria.

Objective: We studied the influence of seizure pattern morphology on detection rate and detection delay of an automatic seizure detection system. We correlated seizure pattern morphology with seizure onset zone and assessed the influence of seizure onset zone on the performance of the seizure detection system.

Methods: We analyzed 10. Read More

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Hippocampal spikes have heterogeneous scalp EEG correlates important for defining IEDs.

Epilepsy Res 2022 05 30;182:106914. Epub 2022 Mar 30.

Department of Neurology, ⁎Neurosurgery and ̂ Pediatrics, The University of Chicago, Chicago, IL 60637, USA. Electronic address:

Objective: To identify scalp EEG correlates of hippocampal spikes in patients with mesial temporal lobe epilepsy (mTLE).

Methods: We recorded scalp and intracranial EEG simultaneously in 20 consecutive surgical candidates with mTLE. Hippocampal spikes were identified from depth electrodes during the first hour of sleep on the first night of recording in the epilepsy monitoring unit, and their scalp EEG correlates were identified. Read More

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Electrical status epilepticus during sleep (ESES) in benign childhood epilepsy with Centrotemporal spikes (BCECTS): insights into predictive factors, and clinical and EEG outcomes.

Eur Rev Med Pharmacol Sci 2022 03;26(6):1885-1896

Department of Pediatric Neurology, Adana City Training and Research Hospital, Adana, Turkey.

Objective: Benign childhood epilepsy with centro-temporal spikes (BCECTS), otherwise known as benign rolandic epilepsy, is the most common focal epilepsy in childhood. This study aimed to evaluate the development and resolution of ESES in children with BCECTS and evaluate the clinical and electroencephalography (EEG) parameters associated with prognosis.

Patients And Methods: Resolution of ESES was defined as the reduction of the spike-wave index (SWI) to <50%. Read More

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Response characteristics of objective perimetry in persons living with epilepsy.

J Neurol Sci 2022 05 25;436:120237. Epub 2022 Mar 25.

Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia. Electronic address:

Purpose: To investigate safety and visual-field changes in people with epilepsy undergoing multifocal Pupillographic Objective Perimetry (mfPOP).

Methods: 15 people with epilepsy and 15 controls underwent mfPOP in the context of routine clinical EEG testing. Safety measures comprised the proportion of participants developing an aura or seizure, a photoparoxysmal response, or increased epileptiform activity on their EEG during mfPOP. Read More

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Kinesigenic dyskinesias after ENT surgery misdiagnosed as focal epilepsy.

BMJ Case Rep 2022 Mar 29;15(3). Epub 2022 Mar 29.

Neurology, Faculty of Medicine, Ludwig Maximilians University Munich, Munich, Germany.

We describe a man in his 30s who presented with paroxysmal right-sided dyskinesias of the arm and neck, misdiagnosed with drug-resistant focal epilepsy. Two months earlier he had undergone surgery for chronic sinusitis. Immediately after this procedure, he developed hemiparesis, hemiataxia, paresthesias and disturbances in verbal fluency. Read More

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SEEG Functional Connectivity Measures to Identify Epileptogenic Zones: Stability, Medication Influence, and Recording Condition.

Neurology 2022 05 25;98(20):e2060-e2072. Epub 2022 Mar 25.

From the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.

Background And Objectives: Functional connectivity (FC) measures can be used to differentiate epileptogenic zones (EZs) from non-EZs in patients with medically refractory epilepsy. Little work has been done to evaluate the stability of stereo-EEG (SEEG) FC measures over time and their relationship with antiseizure medication (ASM) use, a critical confounder in epilepsy FC studies. We aimed to answer the following questions: Are SEEG FC measures stable over time? Are they influenced by ASMs? Are they affected by patient data collection state?

Methods: In 32 patients with medically refractory focal epilepsy, we collected a single 2-minute prospective SEEG resting-state (awake, eyes closed) data set and consecutive 2-minute retrospective pseudo-rest (awake, eyes open) data sets for days 1-7 postimplantation. Read More

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Presurgical evaluation of drug-resistant paediatric focal epilepsy with PISCOM compared to SISCOM and FDG-PET.

Seizure 2022 Apr 15;97:43-49. Epub 2022 Mar 15.

Nuclear Medicine Department, Hospital Clínic, C/Villarroel 170, Barcelona 08036, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain. Electronic address:

Purpose: Children with drug-resistant focal epilepsy have a compromised quality of life. Epilepsy surgery can control or significantly reduce the seizures. We assessed and compared the usefulness of PISCOM, a new nuclear imaging processing technique, with SISCOM and 18F-FDG PET (FDG-PET) in pre-surgical evaluation of paediatric drug-resistant focal epilepsy. Read More

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Cost of pre-surgical evaluation for epilepsy surgery: A single-center experience.

Epilepsy Res 2022 05 16;182:106910. Epub 2022 Mar 16.

Department of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK; Department of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK; Chalfont Centre for Epilepsy, Chalfont St Peter, Buckinghamshire SL9 0RJ, UK.

Objective: To estimate the cost and time taken to evaluate adults with drug-resistant focal epilepsy for potentially curative surgery.

Methods: We reviewed data on 100 consecutive individuals at a tertiary referral center evaluated for epilepsy surgery in 2017. The time elapsed between referral and either surgery or a definitive decision not to progress was measured. Read More

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Two types of clinical ictal direct current shifts in invasive EEG of intractable focal epilepsy identified by waveform cluster analysis.

Clin Neurophysiol 2022 05 9;137:113-121. Epub 2022 Mar 9.

Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto-shi, Kyoto 606-8507, Japan. Electronic address:

Objective: To determine clinically ictal direct current (DC) shifts that can be identified by a time constant (TC) of 2 s and to delineate different types of DC shifts by different attenuation patterns between TC of 10 s and 2 s.

Methods: Twenty-one patients who underwent subdural electrode implantation for epilepsy surgery were investigated. For habitual seizures, we compared (1) the peak amplitude and (2) peak latency of the earliest ictal DC shifts between TC of 10 s and 2 s. Read More

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Safety and efficacy of responsive neurostimulation in the pediatric population: Evidence from institutional review and patient-level meta-analysis.

Epilepsy Behav 2022 04 14;129:108646. Epub 2022 Mar 14.

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.

Background: Responsive neurostimulation (RNS) is a novel technology for drug-resistant epilepsy rising from bilateral hemispheres or eloquent cortex. Although recently approved for adults, its safety and efficacy for pediatric patients is under investigation.

Methods: A comprehensive literature search (Pubmed/Medline, Scopus, Cochrane) was conducted for studies on RNS for pediatric epilepsy (<18 y/o) and supplemented by our institutional series (4 cases). Read More

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Tracking cortical excitability dynamics with transcranial magnetic stimulation in focal epilepsy.

Ann Clin Transl Neurol 2022 04 17;9(4):540-551. Epub 2022 Mar 17.

Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, The Netherlands.

Introduction: The lack of reliable biomarkers constrain epilepsy management. We assessed the potential of repeated transcranial magnetic stimulation with electromyography (TMS-EMG) to track dynamical changes in cortical excitability on a within-subject basis.

Methods: We recruited people with refractory focal epilepsy who underwent video-EEG monitoring and drug tapering as part of the presurgical evaluation. Read More

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Characterising seizure development, behavioural comorbidities and neuroinflammation in a self-sustained electrical status epilepticus model of mesial temporal lobe epilepsy in C57BL/6J mice.

Neurobiol Dis 2022 06 11;168:105688. Epub 2022 Mar 11.

Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne Brain Centre, Parkville, Victoria 3050, Australia; Department of Neuroscience, Central Clinical School, Monash University, Department of Neurology, The Alfred Hospital, Melbourne, Victoria 3004, Australia. Electronic address:

Objective: Status epilepticus (SE) models in rodents are commonly used to research mesial temporal lobe epilepsy (mTLE) in translational epilepsy research. However, due to differences in susceptibility of mice strains to chemoconvulsants, developing this model in mice is challenging. Mice offer experimental advantages; in particular, the ability to use transgenic strains could provide novel insights about neurobiological mechanisms or ease of genetic modification to test potential therapeutic targets. Read More

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Seizure types associated with negative arterial spin labeling and positive diffusion-weighted imaging on peri-ictal magnetic resonance imaging.

J Neurol Sci 2022 05 7;436:120223. Epub 2022 Mar 7.

Department of Neurosurgery, Graduate School of Biomedical Sciences, University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Tokushima, Japan.

Purpose: Arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) are useful for assessing hyperperfusion and cytotoxic edema, respectively, caused by acute seizures. This study investigated the clinical characteristics associated with normal ASL findings and DWI abnormalities in patients with acute seizures.

Methods: Overall, 41 patients with ASL and DWI images that were obtained within 48 h of focal onset seizure diagnosis, due to epilepsy or acute symptomatic seizures, were divided into groups based on initial ASL findings (ASL-negative vs. Read More

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