10,311 results match your criteria Localization-related Epilepsies on EEG


Localization value of ictal turning prone.

Seizure 2018 Dec 7;69:57-60. Epub 2018 Dec 7.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

Purpose: Ictal semiology complements ictal EEG in identifying the likely epileptogenic zone. Ictal turning prone (ITP) with body turning of 90 ° or more can be seen with frontal lobe epilepsies. The aim of our study was to evaluate the localizing value of ITP in a general population of patients undergoing long term video-EEG monitoring. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.11.003DOI Listing
December 2018
1 Read

Deep brain activities can be detected with magnetoencephalography.

Nat Commun 2019 02 27;10(1):971. Epub 2019 Feb 27.

Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, 13005, France.

The hippocampus and amygdala are key brain structures of the medial temporal lobe, involved in cognitive and emotional processes as well as pathological states such as epilepsy. Despite their importance, it is still unclear whether their  neural activity can be recorded non-invasively. Here, using simultaneous intracerebral and magnetoencephalography (MEG) recordings in patients with focal drug-resistant epilepsy, we demonstrate a direct contribution of amygdala and hippocampal activity to surface MEG recordings. Read More

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http://dx.doi.org/10.1038/s41467-019-08665-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393515PMC
February 2019
5 Reads

Controlling seizure propagation in large-scale brain networks.

PLoS Comput Biol 2019 02 25;15(2):e1006805. Epub 2019 Feb 25.

Aix Marseille Université, Inserm, Institut de Neurosciences des Systèmes, UMR_S 1106, 13005, Marseille, France.

Information transmission in the human brain is a fundamentally dynamic network process. In partial epilepsy, this process is perturbed and highly synchronous seizures originate in a local network, the so-called epileptogenic zone (EZ), before recruiting other close or distant brain regions. We studied patient-specific brain network models of 15 drug-resistant epilepsy patients with implanted stereotactic electroencephalography (SEEG) electrodes. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405161PMC
February 2019
1 Read

Large-Scale 3-5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 12.

Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, 1202 Geneva, Switzerland.

Large-scale slow oscillations allow the integration of neuronal activity across brain regions during sensory or cognitive processing. However, evidence that this form of coding also holds for pathological networks, such as for distributed networks in epileptic disorders, does not yet exist. Here, we show in a mouse model of unilateral hippocampal epilepsy that epileptic fast ripples generated in the neocortex distant from the primary focus occur during transient trains of interictal epileptic discharges. Read More

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http://dx.doi.org/10.1523/ENEURO.0494-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378326PMC
April 2019
4 Reads

Stridor as initial presentation of rolandic epilepsy.

Int J Pediatr Otorhinolaryngol 2019 Apr 30;119:183-184. Epub 2019 Jan 30.

Department of Otorhinolaryngology, Centro Hospitalar Vila Nova de Gaia/Espinho, Unidade 1, Serviço de Otorrinolaringologia, Pavilhão Feminino, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal.

The authors present the case of a 5-year-old girl referred to our institution due to several episodes of nocturnal stridor with ocular retroversion and parental notion of apnea. She has been previously submitted to adenotonsillectomy. Due to symptoms worsening she was referred to our hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193005
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http://dx.doi.org/10.1016/j.ijporl.2019.01.040DOI Listing
April 2019
11 Reads

Seizures and Epilepsy.

Authors:
Emily L Johnson

Med Clin North Am 2019 Mar 3;103(2):309-324. Epub 2018 Dec 3.

Department of Neurology, Johns Hopkins School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address:

Epilepsy affects 65 million people worldwide, and is a leading neurologic cause of loss of quality-adjusted life years. The diagnosis of seizures and epilepsy often depends on a careful history, and is supported with electroencephalogram and imaging. First-line treatment of epilepsy includes medical management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00257125183012
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http://dx.doi.org/10.1016/j.mcna.2018.10.002DOI Listing
March 2019
27 Reads

The utility of Jerk-locked back averaging technique in diagnosis of generalized myoclonic epilepsy with normal scalp EEG: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14185

Department of Neurology, Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, 71, Xinmin Street, Changchun, P. R. China.

Rationale: The diagnosis of myoclonic epilepsy and the classification of generalized or partial type may be challenging, especially when the scalp electroencephalogram (EEG) is normal. In such situation, how to apply another electrophysiological technique to begin the diagnosis and classification? The utility of Jerk-locked back averaging technique has been described in our case.

Patient Concerns: A Chinese patient (male, 21 years old) presented with frequent unilateral or bilateral shoulder-jerking. Read More

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http://dx.doi.org/10.1097/MD.0000000000014185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370162PMC
January 2019
1 Read

[Morphometric analysis program combined with magnetoencephalogram in the localization of epileptogenic foci in MRI-negative pharmacoresistant focal epilepsy patients].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(1):14-19

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

To investigate the value of morphometric analysis program (MAP) combined with magnetoencephalogram (MEG) in the localization of epileptogenic foci in MRI-negative pharmacoresistant focal epilepsy (MNPFE) patients. A total of 42 consecutive MNPFE patients from Epilepsy center, Xuanwu Hospital, Capital Medical University from January 2015 to December 2016 were enrolled. The analysis process of MAP and magnetoencephalography (MEG) were performed independently. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.01.004DOI Listing
January 2019
8 Reads

Automated Source Estimation of Scalp EEG Epileptic Activity Using eLORETA Kurtosis Analysis.

Neuropsychobiology 2019 9;77(2):101-109. Epub 2019 Jan 9.

Department of Psychiatry, Kansai Medical University, Osaka, Japan.

Objectives: eLORETA (exact low-resolution brain electromagnetic tomography) is a technique created by Pascual-Marqui et al. [Int J Psychophysiol. 1994 Oct; 18(1): 49-65] for the 3-dimensional representation of current source density in the brain by electroencephalography (EEG) data. Read More

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http://dx.doi.org/10.1159/000495522DOI Listing
March 2019
3 Reads

Aberrant epileptic seizure identification: A computer vision perspective.

Seizure 2019 Feb 20;65:65-71. Epub 2018 Dec 20.

Department of Mater Advanced Epilepsy Unit, Mater Centre for Neurosciences, Brisbane, Australia.

Purpose: The recent explosion of artificial intelligence techniques in video analytics has highlighted the clinical relevance in capturing and quantifying semiology during epileptic seizures; however, we lack an automated anomaly identification system for aberrant behaviors. In this paper, we describe a novel system that is trained with known clinical manifestations from patients with mesial temporal and extra-temporal lobe epilepsy and presents aberrant semiology to physicians.

Methods: We propose a simple end-to-end-architecture based on convolutional and recurrent neural networks to extract spatiotemporal representations and to create motion capture libraries from 119 seizures of 28 patients. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.12.017DOI Listing
February 2019
4 Reads

Changes in background electroencephalographic activity in benign childhood epilepsy with centrotemporal spikes after oxcarbazepine treatment: a standardized low-resolution brain electromagnetic tomography (sLORETA) study.

BMC Neurol 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

Background: Several neuroimaging studies have reported neurophysiological alterations in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS). However, reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Moreover, background electroencephalography (EEG) in cases of BCECTS has not been performed often. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-018-1228-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317234PMC
January 2019
13 Reads

Magnetoencephalography as a Prognostic Tool in Patients with Medically Intractable Temporal Lobe Epilepsy.

World Neurosurg 2019 Mar 19;123:e753-e759. Epub 2018 Dec 19.

Brain Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Background: Most surgical treatments for medically intractable temporal lobe epilepsy are helpful. When a patient has persistent symptoms after surgery, there are no tests that accurately predict whether a patient will have remnant epileptic foci. The aim of this study was to evaluate the usefulness of magnetoencephalography (MEG) as a prognostic tool in patients with temporal lobe epilepsy. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.024DOI Listing
March 2019
2.417 Impact Factor

Frequency and Stratification of Epileptogenic Lesions in Elderly With New Onset Seizures.

Front Neurol 2018 30;9:995. Epub 2018 Nov 30.

American University of Beirut Medical Center, Beirut, Lebanon.

To evaluate prospectively the frequency of epileptogenic lesions in a consecutive cohort of elderly patients presenting with new onset unprovoked seizures, and who underwent a complete evaluation including dedicated epilepsy protocol MRI. We included all consecutive patients 60 years or older who participated in a prospective study on new onset epilepsy. The work-up included the acquisition of a dedicated epilepsy protocol MRI and a 3 h video/EEG recording. Read More

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http://dx.doi.org/10.3389/fneur.2018.00995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284348PMC
November 2018
2 Reads

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration.

Proc Natl Acad Sci U S A 2019 01 17;116(1):287-296. Epub 2018 Dec 17.

Institute for Regenerative Medicine, Texas A&M Health Science Center College of Medicine, Temple, TX 76502;

Medial ganglionic eminence (MGE)-like interneuron precursors derived from human induced pluripotent stem cells (hiPSCs) are ideal for developing patient-specific cell therapy in temporal lobe epilepsy (TLE). However, their efficacy for alleviating spontaneous recurrent seizures (SRS) or cognitive, memory, and mood impairments has never been tested in models of TLE. Through comprehensive video- electroencephalographic recordings and a battery of behavioral tests in a rat model, we demonstrate that grafting of hiPSC-derived MGE-like interneuron precursors into the hippocampus after status epilepticus (SE) greatly restrained SRS and alleviated cognitive, memory, and mood dysfunction in the chronic phase of TLE. Read More

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http://dx.doi.org/10.1073/pnas.1814185115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320542PMC
January 2019
1 Read
9.809 Impact Factor

Quantitative analysis and EEG markers of KCNT1 epilepsy of infancy with migrating focal seizures.

Epilepsia 2019 Jan 7;60(1):20-32. Epub 2018 Dec 7.

INSERM Unit U1129 Infantile Epilepsies and Brain Plasticity, University Paris Descartes, Sorbonne Paris Cité, Paris, France.

Objective: We aimed to characterize epilepsy of infancy with migrating focal seizures (EIMFS), a rare, severe early onset developmental epilepsy related to KCNT1 mutation, and to define specific electroencephalography (EEG) markers using EEG quantitative analysis. The ultimate goal would be to improve early diagnosis and to better understand seizure onset and propagation of EIMFS as compared to other early onset developmental epilepsy.

Methods: EEG of 7 EIMFS patients with KCNT1 mutations (115 seizures) and 17 patients with other early onset epilepsies (30 seizures) was included in this study. Read More

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http://dx.doi.org/10.1111/epi.14605DOI Listing
January 2019
4 Reads

A retrospective observational study of EEG findings and antiepileptic drug use among children referred for EEG to Zambia's University Teaching Hospital.

Epilepsia Open 2018 Dec 16;3(4):503-510. Epub 2018 Oct 16.

Epilepsy Division Department of Neurology University of Rochester Rochester New York U.S.A.

Objective: Despite the heavy burden of epilepsy in Sub-Saharan Africa, there remains a relative paucity of neurophysiology services and limited published data on electroencephalography (EEG) features among African children. The aim of this study was to describe clinical characteristics, EEG findings, and antiepileptic drug (AED) use among children referred for EEG to the University Teaching Hospital in Zambia.

Methods: EEG referrals and reports from 2013-2015 were reviewed. Read More

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http://dx.doi.org/10.1002/epi4.12267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276775PMC
December 2018
2 Reads

Multilobar Resections for 3T MRI-Negative Epilepsy: Worth the Trouble?

World Neurosurg 2019 Mar 28;123:e338-e347. Epub 2018 Nov 28.

Epilepsy Center, Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neuropediatrics, University Children's Hospital Zurich, Zurich, Switzerland. Electronic address:

Objective: Multilobar resection in magnetic resonance imaging (MRI)-negative drug-resistant epilepsy warrants attention because they account for up to one third of MRI-negative epilepsy surgery. Despite their high prevalence, data are sparse, and the risk/benefit ratio continues to be debated. The present study investigated the postoperative seizure outcomes in this especially challenging subgroup. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.170DOI Listing
March 2019
2 Reads

Simultaneous scalp EEG improves seizure lateralization during unilateral intracranial EEG evaluation in temporal lobe epilepsy.

Seizure 2019 Jan 24;64:8-15. Epub 2018 Nov 24.

Department of Neurology, Baylor College of Medicine, Houston, TX 77030, United States; Neurology care line, VA Houston Medical Center, Houston, TX 77030, United States.

Purpose: To determine if simultaneous bilateral scalp EEG (scEEG) can accurately detect a contralateral seizure onset in patients with unilateral intracranial EEG (IEEG) implantation.

Methods: We evaluated 39 seizures from 9 patients with bitemporal epilepsy who underwent simultaneous scEEG and IEEG (SSIEEG). To simulate conditions of unilateral IEEG implantation with a missed contralateral seizure onset, we analyzed the IEEG recording contralateral to the seizure onset (CL- IEEG), in conjunction with simultaneous scEEG. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.11.015DOI Listing
January 2019
3 Reads

Multiphasic Side-Switching Seizures Are Easily Misdiagnosed as Unilateral Seizures During a Single EEG Monitoring Session: A Specific Subtype of Bitemporal Epilepsy.

World Neurosurg 2019 Feb 24;122:656-660. Epub 2018 Nov 24.

Department of Functional Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Bitemporal epilepsy (BTLE) is a specific anatomoelectroclinical phenotype in the spectrum of temporal lobe epilepsy. The diagnosis of BTLE and the evaluation of the degree of seizure lateralization in BTLE patients are greatly influenced by the duration of EEG recording and the number of recorded habitual seizures.

Case Description: A 25-year-old woman had a 5-year history of seizures. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.138DOI Listing
February 2019
7 Reads

Visual field defects after radiosurgery versus temporal lobectomy for mesial temporal lobe epilepsy: Findings of the ROSE trial.

Seizure 2018 Dec 31;63:62-67. Epub 2018 Oct 31.

University of California San Diego, San Diego, CA, United States.

Purpose: Stereotactic radiosurgery (SRS) may be an alternative to anterior temporal lobectomy (ATL) for mesial temporal lobe epilepsy (MTLE). Visual field defects (VFD) occur in 9-100% of patients following open surgery for MTLE. Postoperative VFD after minimally invasive versus open surgery may differ. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183035
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http://dx.doi.org/10.1016/j.seizure.2018.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413861PMC
December 2018
13 Reads

The prevalence of neural antibodies in temporal lobe epilepsy and the clinical characteristics of seropositive patients.

Seizure 2018 Dec 17;63:1-6. Epub 2018 Sep 17.

Department of Neurology, Second Faculty of Medicine, Charles University, Motol University Hospital, Czech Republic.

Purpose: Epileptic seizures are a common manifestation of autoimmune encephalitis, but the role of neural antibodies in long-term epilepsy remains unclear. The aim of this study was to assess the prevalence of neural-surface antibodies (NSAbs) and antibodies against glutamic acid decarboxylase (GAD) in patients with chronic temporal lobe epilepsy (TLE).

Method: Patients with an electro-clinical diagnosis of TLE and a disease duration longer than one year were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183005
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http://dx.doi.org/10.1016/j.seizure.2018.09.009DOI Listing
December 2018
10 Reads

Improved Patient-Independent System for Detection of Electrical Onset of Seizures.

J Clin Neurophysiol 2019 Jan;36(1):14-24

Neurologist and Epileptologist, Gleneagles Global Health City, Chennai, India.

Purpose: To design a non-patient-specific system to detect the electrical onset of seizures in patients with temporal lobe epilepsy.

Methods: We used EEG data from 29 seizures of 18 temporal lobe epilepsy patients who underwent multiday video-scalp EEG monitoring as part of their presurgical evaluations. We segmented each data set into preictal and ictal phases, and identified spectral entropy, spectral energy, and signal energy as useful features for discriminating normal and seizure conditions. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314507PMC
January 2019
26 Reads

Investigation of paediatric occipital epilepsy using stereo-EEG reveals a better surgical outcome than in adults, especially when the supracalcarine area is affected.

Epileptic Disord 2018 Oct;20(5):346-363

Pediatric Neurosurgery, Rothschild Foundation Hospital, Paris.

Occipital epilepsy is the least common among surgical series because: (1) the location makes it hard to asses by EEG; (2) the seizure semiology often reflects propagation; and (3) surgery entails a high risk of neurological deficits. In children, subjective symptoms are harder to assess, adding to the difficulty of a proper diagnosis. We aimed to determine electroclinical characteristics of occipital lobe epilepsy in a paediatric population by reviewing 20 children between one and 16 years, who had undergone intracranial recordings with depth electrodes. Read More

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http://dx.doi.org/10.1684/epd.2018.1000DOI Listing
October 2018
33 Reads

[Initial Experience of Stereotactic EEG Insertion with Anchor Bolt:Problem Extraction and Improvement of Insertion Accuracy].

No Shinkei Geka 2018 Oct;46(10):917-924

Department of Neurosurgery, Kyoto University Graduate School of Medicine.

In recent years, stereotactic electroencephalography(SEEG)has been focused on as a new invasive method for epileptic focus detection. Although the covering area of the brain surface is smaller than the invasive estimation with subdural electrodes, SEEG can evaluate foci that are deeply seated, noncontiguous leaves, and/or bilateral hemispheres. In addition, SEEG can capture consecutive changes in seizure activity in three dimensions. Read More

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http://dx.doi.org/10.11477/mf.1436203839DOI Listing
October 2018
19 Reads

Ictal SPECT reveals different epileptogenic zones in frontal lobe epilepsy.

Epileptic Disord 2018 Oct;20(5):447-450

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

We report a patient with frontal lobe epilepsy due to a right frontal astrocytoma (WHO Grade III) in whom two ictal SPECTs (single photon emission tomography) were performed during two seizures with different semiology and different EEG seizure patterns. Subtraction of ictal and interictal SPECT showed right lateral frontal hyperperfusion during a left face clonic seizure, and right mesial fronto-polar hyperperfusion during a subclinical seizure. This report demonstrates that ictal SPECT may reflect different seizure semiology from the frontal lobe of the same individual and that simultaneous EEG is indispensable for the correct interpretation of SPECT in epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2018.0991DOI Listing
October 2018
18 Reads

Stimulation-induced ictal vocalisation of left frontal lobe origin.

Epileptic Disord 2018 Oct;20(5):418-422

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

Pure ictal non-speech vocalisation occurs in frontal and temporal lobe epilepsies. Electrical stimulation of supplementary motor areas is reported to evoke vocalisation in selected patients. Here, we report a patient with focal epilepsy of the left anterior insula who had isolated monotonous vocalisation elicited by electrical stimulation of the left superior frontal gyrus. Read More

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http://dx.doi.org/10.1684/epd.2018.0990DOI Listing
October 2018
17 Reads

Stereo-electroencephalography-guided radiofrequency thermocoagulation in patients with focal epilepsy: A systematic review and meta-analysis.

Epilepsia 2018 12 21;59(12):2296-2304. Epub 2018 Oct 21.

Faculty of Medicine Claude Bernard, University of Lyon, Lyon, France.

Objective: Despite the increasing number of studies reporting results of stereo-electroencephalography (SEEG)-guided radiofrequency-thermocoagulation (SEEG-guided RF-TC) in the treatment of patients with drug-resistant focal epilepsy, the exact efficacy of this approach remains unclear. The seizure-freedom rate varies greatly across studies and the factors associated with efficacy have not been formally investigated.

Methods: All prospective or retrospective studies reporting efficacy and/or safety of SEEG-guided RF-TC in patients with drug-resistant focal epilepsy were included. Read More

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http://doi.wiley.com/10.1111/epi.14584
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http://dx.doi.org/10.1111/epi.14584DOI Listing
December 2018
12 Reads

Altered S100 Calcium-Binding Protein B and Matrix Metallopeptidase 9 as Biomarkers of Mesial Temporal Lobe Epilepsy with Hippocampus Sclerosis.

J Mol Neurosci 2018 Dec 20;66(4):482-491. Epub 2018 Oct 20.

Research on Children with Special Needs Department, National Research Centre, Giza, Egypt.

Mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) is the most common form of partial epilepsy. The aim of the present study is to highlight possible and suitable biomarkers that can help in the diagnosis and prognosis of this intractable form of epilepsy. The study was carried out on 30 epileptic patients of both sexes with complex partial seizures, having an age ranging from 4 to 30 years and were selected from the outpatient epilepsy clinic at the Kasr El-Aini Hospital in Cairo, Egypt. Read More

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http://link.springer.com/10.1007/s12031-018-1164-5
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http://dx.doi.org/10.1007/s12031-018-1164-5DOI Listing
December 2018
15 Reads
2.343 Impact Factor

Prognostic factors determining poor postsurgical outcomes of mesial temporal lobe epilepsy.

PLoS One 2018 19;13(10):e0206095. Epub 2018 Oct 19.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objectives: To investigate the long-term postoperative outcomes and predictive factors associated with poor surgical outcomes in mesial temporal lobe epilepsy (MTLE).

Materials And Methods: We enrolled patients with MTLE who underwent resective surgery at single university-affiliated hospital. Surgical outcomes were determined using a modified Engel classification at the 2nd and 5th years after surgery and the last time of follow-up. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206095PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195284PMC
March 2019
2 Reads

Comparison of electroencephalographic findings with hippocampal magnetic resonance imaging volumetry in dogs with idiopathic epilepsy.

J Vet Intern Med 2018 Nov 16;32(6):2037-2044. Epub 2018 Oct 16.

Department of Internal Medicine and Clinic for Horses, Dogs and Cats, The Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.

Background: In humans, temporal lobe epilepsy (TLE), is a type of focal epilepsy occurring mainly in the mesial TLE (mTLE), commonly associated with hippocampal sclerosis (HS).

Objectives: According to recent studies, TLE might also occur in dogs and could be associated with hippocampal atrophy (HA)/HS. To date, hippocampal lesions have not been correlated with electroencephalographic (EEG) findings in epileptic dogs. Read More

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http://dx.doi.org/10.1111/jvim.15323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271325PMC
November 2018
3 Reads

Efficacy of levetiracetam for reducing rolandic discharges in comparison with carbamazepine and valproate sodium in rolandic epilepsy.

Seizure 2018 Nov 3;62:79-83. Epub 2018 Oct 3.

Graduate Faculty of Interdisciplinary Research, Graduate School, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.

Purpose: The main purpose of this study was to compare the efficacy of levetiracetam (LEV) with the older antiepileptic drugs (AEDs) for preventing atypical evolution in children with Rolandic epilepsy (RE). Accordingly, the present study compared the efficacy of older AEDs (carbamazepine (CBZ) and valproate sodium (VPA)) with LEV in reducing rolandic discharges (RDs) on interictal electroencephalogram (EEG) in children with RE.

Methods: Patients in this heterogenous study were subdivided into CBZ, VPA and LEV groups in accordance with the initial monotherapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183024
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http://dx.doi.org/10.1016/j.seizure.2018.10.002DOI Listing
November 2018
1 Read

Intracranial Electrode Placement for Seizures Before Temporal Lobectomy: A Risk-Benefit Analysis.

World Neurosurg 2019 Jan 25;121:e215-e222. Epub 2018 Sep 25.

Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address:

Background And Objective: Anterior temporal lobectomy (ATL) is the most common surgical procedure for refractory temporal lobe epilepsy. When scalp electroencephalography cannot adequately identify an epileptogenic site, electrode implantation may be used to monitor epileptic activity and localize a target focus before surgical resection. Whether the advantage of improved seizure localization justifies the added risk of electrode placement remains unclear. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.079DOI Listing
January 2019
5 Reads

Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology.

Acta Neurol Scand 2018 Dec 19;138(6):475-481. Epub 2018 Sep 19.

Department of Pediatric Neurology, Developmental Medicine and Social Pediatrics, University of Munich, Munich, Germany.

Objectives: Neuropsychological sequelae are a feature of benign epilepsy with centrotemporal spikes (BECTS) in children. A correlation between the frequency of interictal EEG discharges and the cognitive as well as behavioral profile of the patients has been suspected but not proven.

Materials And Methods: Children with BECTS that had not yet been treated were included into a randomized controlled trial. Read More

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http://dx.doi.org/10.1111/ane.13015DOI Listing
December 2018
1 Read

Use of Subtemporal Electrode Chains and Their Contribution to Presurgical Evaluation.

Neurodiagn J 2018 ;58(3):164-173

a Neurodiagnostic Laboratory Duke University Medical Center , Durham , North Carolina.

Subtemporal electrode chains are part of the international 10-10 system. Since 2012, they have been routinely used at our institution in adult patients with intractable epilepsy who are undergoing video EEG evaluation for epilepsy surgery. In 2016, this was extended to the pediatric population. Read More

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http://dx.doi.org/10.1080/21646821.2018.1491173DOI Listing
November 2018
7 Reads

Single antiepileptic drug levels do not predict adherence and nonadherence.

Acta Neurol Scand 2019 Feb 11;139(2):199-203. Epub 2018 Oct 11.

Medical Sciences Post-graduate Program, Federal University of Santa Catarina, (UFSC), Florianópolis, Brazil.

Objectives: To investigate the significance of "subtherapeutic" vs "therapeutic" antiepileptic drug (AED) plasma levels with respect to treatment adherence.

Material And Methods: One hundred and seventy patients with refractory temporal lobe epilepsy who underwent video-EEG monitoring in view of a surgical indication had their AEDs (carbamazepine, phenobarbital, phenytoin, and valproate) rapidly withdrawn following a standardized schedule. Plasma levels were measured at admission, and during the 2 days of drug withdrawal. Read More

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http://dx.doi.org/10.1111/ane.13033DOI Listing
February 2019
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Putting it all together: Options for intractable epilepsy: An updated algorithm on the use of epilepsy surgery and neurostimulation.

Epilepsy Behav 2018 11 18;88S:33-38. Epub 2018 Sep 18.

University of South Florida, Tampa, FL, United States.

For drug-resistant epilepsy, nonpharmacologic treatments should be considered early rather than late. Of the nondrug treatments, only resective surgery can be curative. Neurostimulation is palliative, i. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.05.030DOI Listing
November 2018
11 Reads

Parasomnia versus epilepsy: An affair of the heart?

Neurophysiol Clin 2018 Oct 15;48(5):277-286. Epub 2018 Sep 15.

NeuroPain Team, Inserm U 1028/CNRS, UMR 5292, University of Lyon, Lyon Neuroscience Research Centre (CRNL), 69677 Bron, France.

Objective: Differential diagnosis between sleep-related epileptic seizures and NREM parasomnia remains challenging. Pathophysiological markers to differentiate both conditions are needed. Activation of autonomic system is present in arousal reactions and epileptic seizures. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.08.002DOI Listing
October 2018
7 Reads

Ictal Asystole Induced by Right Posterior Quadrant Epilepsy: Report of a Radically Treated Case.

World Neurosurg 2018 Dec 14;120:337-342. Epub 2018 Sep 14.

Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Shizuoka, Japan.

Background: Ictal asystole (IA) and ictal bradycardia (IB) are mainly seen with temporal or frontal lobe epilepsy. Many patients with these conditions undergo cardiac pacemaker therapy but not epilepsy surgery.

Case Description: We report the case of a 15-year-old boy with IA and IB secondary to right posterior quadrant epilepsy (PoQE) who underwent right posterior quadrant disconnection, but not cardiac pacemaker implantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183207
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http://dx.doi.org/10.1016/j.wneu.2018.09.030DOI Listing
December 2018
6 Reads

[Febrile seizures: questions and answers].

Medicina (B Aires) 2018;78 Suppl 2:18-24

Cátedra de Neuropediatría, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

A febrile seizure occurs in association with fever in a child aged 6 to 60 months, without central nervous system infection or other known cause of acute seizures in a child without a prior history of afebrile seizures. Febrile seizures occur in about 2-5% of children. Central nervous system infections should be considered in patients with febrile seizures, even though the frequency of this possibility is low, especially when patients do not return to baseline. Read More

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March 2019
18 Reads

Activation of the innate immune system is evident throughout epileptogenesis and is associated with blood-brain barrier dysfunction and seizure progression.

Epilepsia 2018 10 8;59(10):1931-1944. Epub 2018 Sep 8.

Department of (Neuro) Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.

Objective: Because brain inflammation may contribute to the pathophysiology of temporal lobe epilepsy (TLE), we investigated the expression of various inflammatory markers of the innate and adaptive immune system in the epileptogenic human and rat hippocampus in relation to seizure activity and blood-brain barrier (BBB) dysfunction.

Methods: Immunohistochemistry was performed using various immune cell markers (for microglia, monocytes, macrophages, T lymphocytes, and dendritic cells) on hippocampal sections of drug-resistant TLE patients and patients who died after status epilepticus. The expression of these markers was also studied in the electrical post-status epilepticus rat model for TLE, during the acute, latent, and chronic epileptic phase. Read More

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http://dx.doi.org/10.1111/epi.14550DOI Listing
October 2018
7 Reads

Prognostic Factors and Longitudinal Change in Long-Term Outcome of Frontal Lobe Epilepsy Surgery.

World Neurosurg 2019 Jan 3;121:e32-e38. Epub 2018 Sep 3.

Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objective: We aimed to investigate the possible predictive factors and longitudinal change in long-term surgical outcome after refractory frontal lobe epilepsy surgery.

Methods: We retrospectively reviewed 82 patients who underwent frontal lobe resection. Invasive monitoring was performed in 43 patients. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.192DOI Listing
January 2019
17 Reads

The Comorbidity of Focal Epilepsy and Narcolepsy Type 1 - Two Case Reports.

Neuro Endocrinol Lett 2018 05;39(2):95-98

1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

The aim of this study is to remind the possibility of co-occurrence of epilepsy and narcolepsy. In the first case report, narcolepsy type 1 was diagnosed in 29-year-old female. After one year of the treatment with modafinil a new episodes of automatic behavior appeared. Read More

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May 2018
6 Reads

The Imaging of Localization Related Symptomatic Epilepsies: The Value of Arterial Spin Labelling Based Magnetic Resonance Perfusion.

Korean J Radiol 2018 Sep-Oct;19(5):965-977. Epub 2018 Aug 6.

Department of Imaging Sciences & Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Trivandrum 695011, India.

Accurate identification of the epileptogenic zone is an important prerequisite in presurgical evaluation of refractory epilepsy since it affects seizure-free outcomes. Apart from structural magnetic resonance imaging (sMRI), delineation has been traditionally done with electroencephalography and nuclear imaging modalities. Arterial spin labelling (ASL) sequence is a non-contrast magnetic resonance perfusion technique capable of providing similar information. Read More

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http://dx.doi.org/10.3348/kjr.2018.19.5.965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082755PMC
April 2019
6 Reads

[Surgical treatment of epilepsy in patients with mediobasal temporal cavernous malformations].

Zh Vopr Neirokhir Im N N Burdenko 2018;82(4):45-56

Treatment and rehabilitation center, Moscow, Russia.

Objective: Epilepsy is a frequent clinical manifestation of cavernous malformations (CMs) of the mediobasal temporal region (MBTR). Surgical removal of CMs is an excellent technique for treating associated epilepsy and may range from pure lesionectomy to tailored resection of the temporal lobe.

Purpose: The study purpose was to determine the optimal surgical management for epilepsy in patients with CMs of the MBTR. Read More

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http://dx.doi.org/10.17116/neiro201882445DOI Listing
February 2019
45 Reads

Targeting the Mouse Ventral Hippocampus in the Intrahippocampal Kainic Acid Model of Temporal Lobe Epilepsy.

eNeuro 2018 Jul-Aug;5(4). Epub 2018 Aug 8.

Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455.

Here we describe a novel mouse model of temporal lobe epilepsy (TLE) that moves the site of kainate injection from the rodent dorsal hippocampus (corresponding to the human posterior hippocampus) to the ventral hippocampus (corresponding to the human anterior hippocampus). We compare the phenotypes of this new model-with respect to seizures, cognitive impairment, affective deficits, and histopathology-to the standard dorsal intrahippocampal kainate model. Our results demonstrate that histopathological measures of granule cell dispersion and mossy fiber sprouting maximize near the site of kainate injection. Read More

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http://dx.doi.org/10.1523/ENEURO.0158-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102375PMC
March 2019
1 Read

Abnormal cortical activation during an auditory word comprehension task in benign childhood epilepsy with centrotemporal spikes: A magnetoencephalographic study.

Epilepsy Behav 2018 10 16;87:159-166. Epub 2018 Aug 16.

Division of Developmental Neuroscience, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Objective: Benign childhood epilepsy with centrotemporal spikes (BECTS), also known as rolandic epilepsy, has recently been reported to be associated with variable degrees of cognitive dysfunction. Many studies reported poor language ability in children with BECTS compared with healthy control children. To elucidate the harmful effects of BECTS on language cognition, we studied the magnetoencephalographic activity elicited by an auditory language comprehension task. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183029
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http://dx.doi.org/10.1016/j.yebeh.2018.05.035DOI Listing
October 2018
16 Reads

Negative effects of interictal spikes on theta rhythm in human temporal lobe epilepsy.

Epilepsy Behav 2018 10 13;87:207-212. Epub 2018 Aug 13.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Institute for Research and Medical Consultations, Imam Abdulahman Bin Faisal University, Dammam, Saudi Arabia. Electronic address:

Interictal spike is a biomarker of epilepsy that can occur frequently between seizures. Its potential effects on brain oscillations, especially on theta rhythm (4-8 Hz) that is related to a variety of cognitive processes, remain controversial. Using local field potentials recorded from patients with temporal lobe epilepsy (TLE), we investigated here the impact of spikes on theta rhythm immediately after spikes and during the prolonged periods (lasting 4-36 s) between adjacent spikes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050173090
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http://dx.doi.org/10.1016/j.yebeh.2018.07.014DOI Listing
October 2018
18 Reads

Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy.

Neuroimage Clin 2018 30;20:71-84. Epub 2018 Jun 30.

Multimodal Functional Imaging Lab, Department of Biomedical Engineering, McGill University, Duff Medical Building, 3775 Rue University, Montreal, QC H3A 2B4, Canada; Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada; Centre de Recherches Mathématiques, Université de Montréal, Pavillon André-Aisenstadt 2920 Chemin de la tour, Montreal, QC H3T 1J4, Canada; Department of Physics and PERFORM Centre, Concordia University, 7200 Rue Sherbrooke St. W, Montreal, QC H4B 1R6, Canada.

Hubs of brain networks are brain regions exhibiting denser connections than others, promoting long-range communication. Studies suggested the reorganization of hubs in epilepsy. The patterns of connector hub abnormalities specific to mesial temporal lobe epilepsy (mTLE) are unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183021
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http://dx.doi.org/10.1016/j.nicl.2018.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070692PMC
January 2019
25 Reads

Dense array EEG estimated the epileptic focus in a patient with epilepsy secondary to tuberous sclerosis complex.

Brain Dev 2019 Jan 1;41(1):116-120. Epub 2018 Aug 1.

Facility Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Japan.

Purpose: Tuberous sclerosis complex (TSC) is a leading cause of epilepsy, with seizures affecting almost 80-90% of children. We used the concordance between magnetic resonance imaging (MRI) and dense array electroencephalography (dEEG) findings to detect epileptic focus in a patient with TSC.

Methods: A 9-year-old boy with TSC exhibited daily choking spells. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.07.010DOI Listing
January 2019
5 Reads