733,189 results match your criteria Local and Regional Anesthesia


Spinal Cord Stimulation for Loin Pain Hematuria Syndrome: Case Report.

Pain Pract 2018 Dec 16. Epub 2018 Dec 16.

Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, PA.

Loin Pain Hematuria Syndrome (LPHS) is a rare condition characterized by cryptogenic debilitating flank pain and microscopic or macroscopic hematuria. The pathophysiology of LPHS remains poorly understood and diagnosis is made largely by exclusion of alternate pathology. Management strategies can vary widely and include chronic opioid medication and a variety of invasive procedures including regional nerve blocks, transcutaneous electrical nerve stimulation, local capsaicin infusion, and surgical renal denervation. Read More

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December 2018

Three-Dimensional Printing in Anatomy Education:Assessing Potential Ethical Dimensions.

Authors:
D Gareth Jones

Anat Sci Educ 2018 Dec 15. Epub 2018 Dec 15.

Department of Anatomy, University of Otago, Dunedin, New Zealand.

New technological developments have frequently had major consequences for anatomy education, and have raised ethical queries for anatomy educators. The advent of three-dimensional (3D) printing of human material is showing considerable promise as an educational tool that fits alongside cadaveric dissection, plastination, computer simulation, and anatomical models and images. At first glance its ethical implications appear minimal, and yet the more extensive ethical implications around clinical bioprinting suggest that a cautious approach to 3D printing in the dissecting room is in order. Read More

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December 2018

A Comparison of the Shielding Effectiveness of Silicone Oil Vitreous Substitutes when used with Palladium-103 and Iodine-125 Eye Plaques.

Med Phys 2018 Dec 16. Epub 2018 Dec 16.

200 Medical Plaza Ste B265, Los Angeles, CA, 90095.

Purpose: Epi-scleral eye plaques provide excellent local control of ocular melanoma, but vision sparing remains a significant problem with 30% or more of patients experiencing significant visual acuity degradation. The use of silicone oil shielding with Iodine-125 plaques has previously been reported to improve critical structure sparing. We hypothesized that the use of Palliadium-103 would improve the shielding effectiveness of silicone oil due to the strong energy dependence of the photoelectric effect. Read More

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December 2018

Re-examining the role of adjuvant radiation therapy.

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

Surgical Oncology, Northern Clinical School, The University of Sydney, Sydney, Australia.

Previously important roles for adjuvant radiotherapy (RT) in melanoma patients included improved regional control after resection of high-risk nodal disease, to reduce local recurrence for desmoplastic, and other subtypes of melanoma with neurotropism, reducing in-brain relapse of brain metastases after surgery and other situations on a case-by-case basis. This review evaluates the integration of adjuvant RT into clinical practice at this time of rapidly evolving knowledge and improving outcomes from effective systemic therapy. Read More

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December 2018

Completion surgery of residual disease after primary inadequate surgery of retroperitoneal sarcomas can salvage a selected subgroup of patients-A propensity score analysis.

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Background: Patients with retroperitoneal sarcoma (RPSs) who undergo primary inadequate surgery before referral to specialized sarcoma centers may be considered for completion surgery (CS). We wanted to compare the outcome of these patients to those who underwent primary adequate surgery (PAS) at a single referral institution.

Methods: We identified 34 patients who were referred for CS after primary inadequate surgery. Read More

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December 2018

Influences of coal mines, metallurgical plants, urbanization and lithology on the elemental composition of street dust.

Authors:
Gorazd Žibret

Environ Geochem Health 2018 Dec 15. Epub 2018 Dec 15.

Geological Survey of Slovenia, Dimičeva ulica 14, 1000, Ljubljana, Slovenia.

Street dust (SD) acts as a sink and a source of atmospheric particulate matter, which is especially significant in urban environments. World studies of natural and anthropogenic impacts on the elemental composition of SD are generally limited to specific areas or case studies. The objectives of this study are to determine the impacts of different anthropogenic atmospheric dust emitters and natural factors on the chemical composition of SD, and to define sources of variance in elemental composition of SD, temporal variations and geochemical associations of elements on large number of samples, collected in different time periods, anthropogenic environments and geological settings. Read More

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December 2018

Effect of model race and viewing perspective on body attractiveness and body size assessment in young Caucasian women: an eye-tracking study.

Psychol Res 2018 Dec 15. Epub 2018 Dec 15.

School of Psychology, University of Lincoln, Brayford Pool, Lincoln, LN6 7TS, UK.

Research has indicated that Caucasian women gaze more often at waist-hip and chest regions than other local body areas when assessing female body attractiveness and body size, and this stereotypical gaze distribution is further modulated by their own body satisfaction and body composition. However, little is known whether the model race and viewing perspective could affect women's body-viewing gaze behaviour and body perception. Here, we presented female body images of Caucasian, Asian and African avatars in a continuum of common dress sizes in full frontal, mid-profile and rear view, and asked young Caucasian women to rate the perceived body attractiveness and body size. Read More

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December 2018

Ambient geochemical baselines for trace elements in Chernozems-approximation of geochemical soil transformation in an agricultural area.

Environ Monit Assess 2018 Dec 15;191(1):19. Epub 2018 Dec 15.

Wrocław University of Environmental and Life Sciences, Institute of Soil Science and Environmental Protection, Grunwaldzka 53, 50-357, Wrocław, Poland.

The legal regulatory/action levels of trace elements in soils are established at high concentrations, at which the crucial functions of soil are at risk or are eliminated. However, concentrations below these action levels, but above presumed natural levels, may also limit particular ecosystem services, including organic food production. Thus, defining the (ambient) background concentrations is an essential part of environmental or health risk assessment, e. Read More

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December 2018

Official controls regarding artisanal ice cream shops: public health policies and consumer protection in the Italian and European legislative frameworks.

Ann Ig 2019 Jan-Feb;31(1):76-85

Department of Medical and Surgical Sciences and Translational Medicine, Sapienza University of Rome, Rome, Italy.

Ice cream is a widely enjoyed food that is especially popular during summer. To ensure it is safe and ready-to-eat for consumers, legislation imposes a series of obligations for food business operators, and for competent authorities that have to carry out official controls, including official sampling. This article reviews the general and specific requirements applicable to the premises where ice cream is produced, concerning aspects related to health notification obligations and to implementing and maintaining procedures based on the principles of the Hazard Analysis and Critical Control Point system. Read More

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December 2018

Promotion of the mediterranean diet incancer long-survivors by means of the Med-Food Anticancer Program: a pilot study.

Ann Ig 2019 Jan-Feb;31(1):45-51

Discipline of Nutrition and Dietetics, The University of Auckland, New Zealand.

Background: The intervention "Med-Anticancer Food Program" has proven to be effective in promoting the Mediterranean Diet, significantly increasing the Mediterranean Adequacy Index in healthy subjects. There are no studies that have investigated the effectiveness of this intervention in individuals who have had a diagnosis of cancer.

Objective: To perform a pilot study to assess the opportunity of employing the methodology of the Med-Anticancer Food Program in order to encourage "long-term cancer survivors" to adhere to the Mediterranean Diet, as well as healthy people, and this in order to apply the program to larger groups. Read More

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December 2018

Health status, diseases and vaccinations of the homeless in the city of Palermo, Italy.

Ann Ig 2019 Jan-Feb;31(1):21-34

Department of Science for Health Promotion and Mother-Child Care "G. D'Alessandro", University of Palermo, Palermo, Italy.

Introduction: In Italy, as in the rest of the world, the number of homeless people is increasing considerably. Many of them suffer from chronic conditions, mental health problems and addiction to alcohol, drugs or smoking, and need complex medical care. Their health status is often exacerbated by greater difficulty in accessing primary care. Read More

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December 2018

Clinical Outcomes of Patients with Small Rectal Neuroendocrine Tumors Treated Using Endoscopic Submucosal Resection with a Ligation Device.

Digestion 2018 Dec 14;99(1):72-78. Epub 2018 Dec 14.

Department of Gastroenterology, NTT Medical Center Tokyo, Tokyo,

Background/aims: The therapeutic strategies for small rectal neuroendocrine tumors (NETs) have not been standardized. We examined the efficacy and safety of endoscopic submucosal resection with a ligation device (ESMR-L) and the long-term outcomes after endoscopic treatment.

Methods: A total of 181 patients with rectal NETs <10 mm who were treated between May 2002 and May 2017 were retrospectively enrolled. Read More

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December 2018

Preoperative stereotactic radiosurgery before planned resection of brain metastases: updated analysis of efficacy and toxicity of a novel treatment paradigm.

Authors:

J Neurosurg 2018 Dec 14:1-8. Epub 2018 Dec 14.

OBJECTIVEPreoperative stereotactic radiosurgery (SRS) is a feasible alternative to postoperative SRS and may lower the risk of radiation necrosis (RN) and leptomeningeal disease (LMD) recurrence. The study goal was to report the efficacy and toxicity of preoperative SRS in an expanded patient cohort with longer follow-up period relative to prior reports.METHODSThe records for patients with brain metastases treated with preoperative SRS and planned resection were reviewed. Read More

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December 2018

Perceptions of health and healthcare in ex-Army residents of Tameside: a pilot qualitative study.

Authors:
Steven L Senior

J R Army Med Corps 2018 Dec 15. Epub 2018 Dec 15.

Division of Population Health, Health Services Research & Primary Care, University of Manchester, Manchester M13 9PL, UK

Background: Local authorities and other service providers need data on their local ex-military communities to be able to plan services. However, published research and data may not be applicable to the local population. Qualitative research offers a relatively low-cost way to get insights into the needs of local ex-military communities. Read More

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December 2018

Inhibition of CTHRC-1 by its specific monoclonal antibody attenuates cervical cancer cell metastasis.

Biomed Pharmacother 2018 Dec 13;110:758-763. Epub 2018 Dec 13.

Department of Obstetrics and Gynecology, Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai 201499, PR China. Electronic address:

Although combination of surgery and chemo-radiotherapy could cure 80-95% of patients with early cervical cancer, there is still no satisfactory therapeutic strategies for locally advanced and metastatic cervical cancer patients. Our previous study has already investigated that CTHRC-1 is highly expressed not only in the local tissue but also in circulating serum of patients with cervical cancer and played important function on metastasis of cervical cancer cells. In present study, we aimed to see whether circulating specific monoclonal antibody (mAb) to CTHRC-1could inhibit the metastasis of advanced cervical cancer. Read More

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December 2018

Microwave field: High temperature dielectric properties and heating characteristics of waste hydrodesulfurization catalysts.

J Hazard Mater 2018 Dec 10;366:432-438. Epub 2018 Dec 10.

Key Laboratory for Ecological Metallurgy of Multimetallic Mineral, Ministry of Education, Northeastern University, Shenyang, 110819, China.

The exploration of the dielectric properties of waste hydrodesulfurization catalysts has important guiding significance for the development of microwave heat treatment of waste hydrodesulfurization catalysts for the recovery of valuable metals. The resonant cavity perturbation technique was used to measure the dielectric properties of waste catalyst and the mixture of waste catalyst and NaCO during roasting from room temperature to 700 °C at 2450 MHz. The heating properties of the waste catalyst and mixture of waste catalyst and NaCO were determined in the microwave field. Read More

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December 2018

Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease.

Neurobiol Aging 2018 Nov 22;75:83-97. Epub 2018 Nov 22.

Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

In Parkinson's disease (PD), iron accumulation in the substantia nigra (SN) exacerbates oxidative stress and α-synuclein aggregation, leading to neuronal death. However, the influence of iron-related nigral degeneration on the subcortical function and global network configuration in PD remains unknown. Ninety PD patients and 38 normal controls underwent clinical assessments and multimodality magnetic resonance imaging scans. Read More

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November 2018

Mechanical regulation of genome architecture and cell-fate decisions.

Authors:
G V Shivashankar

Curr Opin Cell Biol 2018 Dec 13;56:115-121. Epub 2018 Dec 13.

Mechanobiology Institute, National University of Singapore, Singapore & FIRC Institute of Molecular Oncology (IFOM), Milan, Italy. Electronic address:

Landmark experiments in vitro showed that somatic cells can be reprogrammed to stem-cells by the constitutive expression of particular transcription factors. However, in vivo cells naturally exhibit de-differentiation and trans-differentiation programs, thereby suggesting that the signals from the local mechanical microenvironment may be sufficient to induce stem-cell state transitions. In this review, we discuss recent evidence for the biophysical regulation of genome architecture and nuclear programs. Read More

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December 2018

Fibril bending stiffness of 3D collagen matrices instructs spreading and clustering of invasive and non-invasive breast cancer cells.

Biomaterials 2018 Dec 10;193:47-57. Epub 2018 Dec 10.

Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, 04103, Germany. Electronic address:

Extracellular matrix stiffening of breast tissues has been clinically correlated with malignant transformation and poor prognosis. An increase of collagen fibril diameter and lysyl-oxidase mediated crosslinking has been observed in advanced tumor stages. Many current reports suggest that the local mechanical properties of single fibrillar components dominantly regulate cancer cell behavior. Read More

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December 2018

Novel antibody against oligomeric amyloid-β: Insight into factors for effectively reducing the aggregation and cytotoxicity of amyloid-β aggregates.

Int Immunopharmacol 2018 Dec 13;67:176-185. Epub 2018 Dec 13.

Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun, China; School of Life Science, Jilin University, Changchun, China. Electronic address:

Amyloid-beta 42 (Aβ42) aggregates represent a prominent histopathological feature in Alzheimer's disease (AD); thus, immunotherapy against oligomeric Aβ42 aggregates is considered to be a potentially safe and specific therapeutic strategy. In this study, we identified an anti-oligomeric Aβ42 aggregate single-chain variable fragment (scFv) antibody, HT6, that is capable of efficiently binding to medium-sized Aβ42 aggregates (mainly 18-45 kDa) in vitro with an equilibrium dissociation constant (K) of 3.0 × 10 M, whether they were derived from Aβ42 monomer, larger Aβ42 oligomers, or even fibrils. Read More

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December 2018

ng inputs that may arise from the field Decision tool for climate disasters and infectious disease at sub-national level in India: Ensuring a paradigm shift in health planning from prevalence to vulnerability.

Acta Trop 2018 Dec 13. Epub 2018 Dec 13.

Indian Institute of Public Administration, Delhi, India.

Climate change is considered as a distal determinant of public health which is increasing in importance. India, as an example, has a national action plan for climate change and human health. Sub-national (State) plans for climate change also exist, taking into account the health sector. Read More

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December 2018

LINE-1 retrotransposons become deregulated during the development of ovarian cancer precursor lesions.

Am J Pathol 2018 Dec 13. Epub 2018 Dec 13.

Department of Oncology; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Pathology; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD; Gynecology and Obstetrics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

There is growing evidence that the majority of high-grade serous ovarian carcinomas likely arise from local dissemination of precursor lesions of the fallopian tube. Evolution of these lesions from early "p53 signatures" to latter-stage, serous tubal intraepithelial carcinomas (STICs) is characterized by cytologic atypia, accumulation of somatic mutations, and genomic instability, the etiologies of which remain unclear. Long interspersed element 1 (LINE-1) retrotransposon is expressed in many carcinomas, including high-grade serous ovarian carcinoma, where it contributes to genomic instability; however, the timing of LINE-1 activation during this evolution has yet to be elucidated. Read More

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December 2018

Full thickness intraoral mucosa barrier models for in vitro drug permeation studies employing microneedles.

J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. Electronic address:

The use of permeation enhancers such as microneedles (MNs) to increase drug penetration across intraoral mucosa has increased in recent years. Permeation studies, commonly performed using vertical diffusion cells, are a well-established way to preview formulations and enhance their performance during the development stage. However, to our knowledge, the existing intraoral mucosa barrier models do not permit permeation using MNs-pretreated mucosa, due to their insufficient thickness. Read More

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December 2018

Effects of Different Doses of Mesenchymal Stem Cells on Functional Recovery After Compressive Spinal-Cord Injury in Mice.

Neuroscience 2018 Dec 13. Epub 2018 Dec 13.

Laboratório de Neurodegeneração e Reparo, Departamento de Patologia - Faculdade de Medicina, HUCFF, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

Despite advances in technology and rehabilitation, no effective therapies are available for patients with SCI, which remains a major medical challenge. This study compared the efficacy of 3 different doses of mesenchymal stem cells (MSCs) administered by intraperitoneal injection as a therapeutic strategy for compressive SCI. We used adult female C57BL/6 mice that underwent laminectomy at the T9 level, followed by spinal-cord compression for 1 minute with a 30 g vascular clip. Read More

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December 2018

Nasal respiration is necessary for the generation of γ oscillation in the olfactory bulb.

Neuroscience 2018 Dec 13. Epub 2018 Dec 13.

Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address:

γ oscillations (30-120 Hz) are generated intrinsically within local networks in the mammalian olfactory bulb (OB). The OB directly receives peripheral input from olfactory sensory neurons (OSNs) that can respond to nasal airflow, and centrifugal input from neuromodulatory systems whose activities are affected by the behavioral states of animal. How peripheral and centrifugal input dynamically modulate γ oscillations is unclear. Read More

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December 2018

Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity.

Mol Metab 2018 Nov 28. Epub 2018 Nov 28.

MRC London Institute of Medical Sciences, Du Cane Road, London, W12 0NN, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK. Electronic address:

Objective: Sympathetic nervous system and immune cell interactions play key roles in the regulation of metabolism. For example, recent convergent studies have shown that macrophages regulate obesity through brown adipose tissue (BAT) activation and beiging of white adipose tissue (WAT) via effects upon local catecholamine availability. However, these studies have raised issues about the underlying mechanisms involved including questions regarding the production of catecholamines by macrophages, the role of macrophage polarization state and the underlying intracellular signaling pathways in macrophages that might mediate these effects. Read More

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November 2018

Completely Percutaneous Transaxillary Aortic Valve Implantation Under Local Anesthesia: A Minimalist Alternative Access Approach.

JACC Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Department of Interventional Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address:

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December 2018

Long-term outcomes following minimally invasive and open esophagectomy in Finland: A population-based study.

Eur J Surg Oncol 2018 Dec 7. Epub 2018 Dec 7.

Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.

Background: Studies of long-term survival after minimally invasive and open esophagectomy are needed. The aim of this study was to compare long-term outcomes following minimally invasive and open esophagectomy for esophageal cancer at the population level.

Methods: All patients undergoing minimally invasive (n = 159) or open transthoracic (n = 431) esophagectomy for esophageal cancer in Finland between 2004 and 2014 were identified from nationwide registries. Read More

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December 2018

Local Treatment in Metastatic Prostate Cancer: A Cultural Shift Confronts Power and Selection.

Eur Urol 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

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December 2018

Colonic Ewing Sarcoma/PNET associated with liver metastases: A systematic review and case report.

Pathol Res Pract 2018 Nov 29. Epub 2018 Nov 29.

Mater Salutis" Hospital, ULSS9, 37045 Legnago, Verona, Italy. Electronic address:

Ewing Sarcoma is a highly lethal undifferentiated tumor of bone. ES is a small round cell tumor with etiological and characteristic chromosomal translocations between TET/FET (TLS/FUS, EWSR1, and TAF15) and ETS (E26 transformation-specific) family genes. Generally, therapeutic approach for metastatic Ewing Sarcoma includes both local (surgery and radiotherapy) and systemic (chemotherapy) disease control with an overall cure rate of 20%. Read More

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November 2018

Oral vaccination with influenza hemagglutinin combined with human pulmonary surfactant-mimicking synthetic adjuvant SF-10 induces efficient local and systemic immunity compared with nasal and subcutaneous vaccination and provides protective immunity in mice.

Vaccine 2018 Dec 13. Epub 2018 Dec 13.

Division of Enzyme Chemistry, Institute for Enzyme Research, Tokushima University, Tokushima, Japan. Electronic address:

We reported previously that a synthetic mucosal adjuvant SF-10, which mimics human pulmonary surfactant, delivers antigen to mucosal dendritic cells in the nasal cavity and promotes induction of humoral and cellular immunity. The aim of the present study was to determine the effects of oral administration of antigen combined with SF-10 (antigen-SF-10) on systemic and local immunity. Oral administration of ovalbumin, a model antigen, combined with SF-10 enhanced ovalbumin uptake into intestinal antigen presenting MHC IICD11c cells and their CD11bCD103 and CD11bCD103 subtype dendritic cells, which are the major antigen presenting subsets of the intestinal tract, more efficiently compared to without SF-10. Read More

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December 2018

Opening the toolkit for genetic analysis and control of Anopheles mosquito vectors.

Curr Opin Insect Sci 2018 Dec 26;30:8-18. Epub 2018 Jul 26.

Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.

Anopheles is the only genus of mosquitoes that transmit human malaria and consequently the focus of large scale genome and transcriptome-wide association studies. Genetic tools to define the function of the candidate genes arising from these analyses are vital. Moreover, genome editing offers the potential to modify Anopheles population structure at local and global scale to provide complementary tools towards the ultimate goal of malaria elimination. Read More

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December 2018

Local and controlled release of tamoxifen from multi (layer-by-layer) alginate/chitosan complex systems.

Carbohydr Polym 2019 Feb 11;206:428-434. Epub 2018 Nov 11.

Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), c/ Juan de la Cierva, 3, 28006 Madrid, Spain. Electronic address:

Herein, multilayer polysaccharide films were proposed and characterized as biomaterials for the local and controlled release of an antitumoral drug. To that aim, multilayer films of alginate (Alg) and chitosan (Chi) were built up through spray assisted layer-by-layer (LbL) technique employing an automatic equipment. A specific drug against breast cancer, tamoxifen (TMX), was incorporated in different intermediate positions of the multilayer Alg/Chi films. Read More

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February 2019

Feasibility and clinical outcomes of ureteral stenting in the office procedural suite.

Can J Urol 2018 Dec;25(6):9596-9600

MD/PhD Program, Texas A & M Health Science Center College of Medicine, Temple, Texas, USA.

Introduction: Stent placement is a common procedure for addressing obstructive uropathy. However, lack of operating room (OR) availability can substantially delay this procedure. In this study, we sought to assess the feasibility, safety, and efficacy of this procedure in a clinical setting using nitrous oxide (N2O) and local anesthesia. Read More

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December 2018

Flow-induced density fluctuation assisted nucleation in polyethylene.

J Chem Phys 2018 Dec;149(22):224901

National Synchrotron Radiation Lab and CAS Key Laboratory of Soft Matter Chemistry, Anhui Provincial Engineering Laboratory of Advanced Functional Polymer Film, University of Science and Technology of China, Hefei, China.

The nucleation processes of polyethylene under quiescent and shear flow conditions are comparatively studied with all-atom molecular dynamics simulations. Under both conditions, nucleation is demonstrated to be a two-step process, which, however, proceeds via different intermediate orders. Quiescent nucleation is assisted by local order structures, while flow-induced nucleation is promoted by density fluctuation, which is a coupling effect of conformational and orientational orderings. Read More

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December 2018

Common microscopic structural origin for water's thermodynamic and dynamic anomalies.

J Chem Phys 2018 Dec;149(22):224502

Department of Fundamental Engineering, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.

Water displays a vast array of unique properties, known as water's anomalies, whose origin remains subject to hot debate. Our aim in this article is to provide a unified microscopic physical picture of water's anomalies in terms of locally favored structures, encompassing both thermodynamic and dynamic anomalies, which are often attributed to different origins. We first identify locally favored structures via a microscopic structural descriptor that measures local translational order and provide direct evidence that they have a impact on the anomalies. Read More

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December 2018

Granularity impact on hotspot formation and local chemistry in shocked nanostructured RDX.

Authors:
X Bidault N Pineau

J Chem Phys 2018 Dec;149(22):224703

CEA/DAM/DIF, F-91297 Arpajon, France.

The nanostructuration of energetic materials results in interesting properties. In particular, the detonation of carbon-rich explosives leads to the formation of nanodiamonds, the size of which is linked to the initial size of the explosive nanograins. This correlation could come from the role played by the granularity in the shock properties, especially the local temperature, which could be enhanced when the shock front crosses the various interfaces and nanoporosities of the material. Read More

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December 2018

An Accurate Automated Local Similarity Factor-Based Neural Tree Approach toward Tissue Segmentation of Newborn Brain MRI.

Am J Perinatol 2018 Dec 15. Epub 2018 Dec 15.

Shri Sant Gajanan Maharaj College of Engineering, Shegaon, Maharashtra, India.

Background:  Segmentation of brain MR images of neonates is a primary step for assessment of brain evolvement. Advanced segmentation techniques used for adult brain MRI are not companionable for neonates, due to extensive dissimilarities in tissue properties and head structure. Existing segmentation methods for neonates utilizes brain atlases or requires manual elucidation, which results into improper and atlas dependent segmentation. Read More

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December 2018
1 Read

Patch spaces and fusion strategies in patch-based label fusion.

Comput Med Imaging Graph 2018 Dec 6;71:79-89. Epub 2018 Dec 6.

DTIC, Universitat Pompeu Fabra, Barcelona, Spain.

In the field of multi-atlas segmentation, patch-based approaches have shown promising results in the segmentation of biomedical images. In the most common approach, registration is used to warp the atlases to the target space and then the warped atlas labelmaps are fused into a consensus segmentation based on local appearance information encoded in form of patches. The registration step establishes spatial correspondence, which is important to obtain anatomical priors. Read More

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December 2018

Molecular simulation of the structure of folate and antifolates at physiological conditions.

J Mol Graph Model 2018 Dec 4;87:172-184. Epub 2018 Dec 4.

Laboratory of Quantum and Computational Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia, 1 James Bourchier Blvd, 1164, Sofia, Bulgaria. Electronic address:

The study is focused on description of folate and several antifolates at physiological conditions. Knowledge of the molecular structure and dynamics is important for understanding their biological activity and therapeutic application. They are modelled in saline by atomistic molecular dynamics simulations and characterized in detail. Read More

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December 2018
1 Read

Early response of C2C12 myotubes to a sub-cytotoxic dose of hemorrhagic metalloproteinase HF3 from Bothrops jararaca venom.

J Proteomics 2018 Dec 12. Epub 2018 Dec 12.

Laboratório Especial de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Instituto Butantan, São Paulo, Brazil. Electronic address:

Manifestations of local tissue damage, such as hemorrhage and myonecrosis, are among the most dramatic effects of envenomation by viperid snakes. Snake venom metalloproteinases (SVMPs) of the P-III class are main players of the hemorrhagic effect due to their activities in promoting blood vessel disruption. Hemorrhagic Factor 3 (HF3), a P-III class SVMP from Bothrops jararaca, shows a minimum hemorrhagic dose of 240 fmol on rabbit skin. Read More

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December 2018
1 Read

A Second course of stereotactic image-guided robotic radiosurgery for patients with cerebral metastasis.

World Neurosurg 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin, China. Electronic address:

Objectives: The purpose of this research was to study the outcome of brain metastases in a cohort of patients undergoing a second course of stereotactic image-guided robotic radiosurgery, and to identify predictors corelated with survival.

Methods: A total of 63 patients with primary malignancies underwent a second course of Cyberknife radiosurgery for intracranial progression, including recurrence and new metastases after initial stereotactic radiosurgery (SRS). Overall survival (OS) and control rate were calculated by Kaplan-Meier. Read More

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December 2018

Synthesis and characterization of nanostructured lipid-poloxamer organogels for enhanced skin local anesthesia.

Eur J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.

Human and Natural Sciences Center, Federal University of ABC, Santo André, SP, Brazil. Electronic address:

The aim of this study was to synthesize a novel drug delivery system using organogels (ORGs) and characterize its physicochemical properties, in vitro and ex vivo permeation abilities, cytotoxicity and in vivo local anesthetic effects. The ORG formulations contained a mixture of oleic acid-lanolin (OA-LAN), poloxamer (PL407), and the commonly used local anesthetic lidocaine (LDC). The main focus was to evaluate the impact of LAN and PL407 concentrations on the ORG structural features and their biopharmaceutical performance. Read More

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December 2018
1 Read

Physical exercise enhances adult cortical plasticity in a neonatal rat model of hypoxic-ischemic injury: Evidence from BOLD-fMRI and electrophysiological recordings.

Neuroimage 2018 Dec 12. Epub 2018 Dec 12.

Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06351, South Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea; Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, South Korea; Animal Research and Molecular Imaging, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, 06351, South Korea; Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea. Electronic address:

Neuroplasticity is considered essential for recovery from brain injury in developing brains. Recent studies indicate that it is especially effective during early postnatal development and during the critical period. The current study used functional magnetic resonance imaging (fMRI) and local field potential (LFP) electrophysiological recordings in rats that experienced neonatal hypoxic-ischemic (HI) injury during the critical period to demonstrate that physical exercise (PE) can improve cortical plasticity even when performed during adulthood, after the critical period. Read More

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December 2018

Long-term outcomes for patients with desmoid fibromatosis treated with radiation therapy: a 10-year update and re-evaluation of the role of radiation therapy for younger patients.

Int J Radiat Oncol Biol Phys 2018 Dec 12. Epub 2018 Dec 12.

Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX.

Objective: To update our experience with long-term outcomes in patients with desmoid fibromatosis treated with radiation therapy (RT) and to characterize factors associated with increased risk of local recurrence.

Methods: We reviewed the records of 209 consecutive patients with desmoid fibromatosis treated with RT, either alone or as combined modality therapy (CMT) with surgery, at our institution from 1965 to 2015.

Results: Median follow-up time was 98 months (range, 1-509 months). Read More

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December 2018

Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs.

J Control Release 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark. Electronic address:

Albumin is a highly successful tool of drug delivery providing drastically extended body and blood residence time for the associated cargo, but it only traffics single drug copies at a time. In turn, macromolecular prodrugs (MP) are advantaged in carrying a high drug payload but offering only a modest extension of residence time to the conjugated drugs. In this work, we engineer MP to contain terminal groups that bind to albumin via non-covalent association and reveal that this facile measure affords a significant protraction for the associated polymers. Read More

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December 2018

The testosterone metabolite 3α-androstanediol inhibits oxidative stress-induced ERK phosphorylation and neurotoxicity in SH-SY5Y cells through an MKP3/DUSP6-dependent mechanism.

Neurosci Lett 2018 Dec 12. Epub 2018 Dec 12.

Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada. Electronic address:

Testosterone exerts neuroprotective effects on the brain, but the mechanisms by which these effects are exerted appear to be different in males and females. While in females they involve local conversion to estradiol, in males they may be androgen receptor-dependent, or mediated through metabolism to neurosteroids such as 5α-androstane-3α,17β-diol (3α-diol), which acts through different mechanisms than testosterone itself. Recently, we demonstrated that 3α-diol can protect neurons and neuronal-like cells against oxidative stress-induced neurotoxicity associated with prolonged phosphorylation of the extracellular signal-regulated kinase (ERK). Read More

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December 2018

Focal Ablative Therapy for Renal Cell Carcinoma in Transplant Allograft Kidneys.

Urology 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Objectives: To evaluate outcomes after focal ablative therapy for renal cell carcinoma (RCC) in transplant allograft kidneys METHODS: After institutional review board approval, patients with a history of RCC in a transplanted allograft kidney who underwent focal ablative therapy were identified. Complete chart reviews were performed and the relevant data were extracted for cumulative analysis.

Results: Six patients were treated with focal ablative therapy for RCC in a transplanted allograft kidney at our institutional between 2010-2017. Read More

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December 2018
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Analgesic and anti-edemic properties of etifoxine in models of inflammatory sensitization.

Eur J Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Centre National de la Recherche Scientifique and University of Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 67000 Strasbourg, France. Electronic address:

Inflammatory processes are critical promoting factors of chronic pain states, mostly by inducing peripheral and central sensitization of the nociceptive system. These processes are associated with a massive increase in glutamatergic transmission, sometimes facilitated by spinal disinhibition. In this study, we used etifoxine, a non-benzodiazepine anxiolytic known to amplify inhibition mediated by gamma-aminobutyric acid type A (GABA) receptors in pain processing regions, either directly (through allosteric modulation) or indirectly (through the synthesis of endogenous neurosteroids). Read More

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December 2018
1 Read

Management of invasive squamous cell carcinomas of the conjunctiva Treatment of invasive conjunctival carcinoma.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Pasteur 2 Teaching Hospital, Nice, France.

Purpose: Ocular Surface Squamous Neoplasia includes a spectrum of diseases from dysplasia to invasive squamous cell carcinoma of the conjunctiva. Whether the degree of invasion influences outcomes is debated. We evaluated the outcomes and management of conjunctival carcinomas defined as ≤0. Read More

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December 2018
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