741,207 results match your criteria Local & Regional Anesthesia [Journal]


[Pedicled Flaps in the Reconstruction of Complex Wounds at the Lower Extremity].

Z Orthop Unfall 2019 Feb 20;157(1):95-108. Epub 2019 Feb 20.

The present refresher article highlights the current role of pedicled flaps in the reconstruction of complex wounds at the lower extremity. Due to the increasing standardization and ongoing improvements in microsurgery and in view of the fact that local tissue limitation and elevated rates of wound healing disorders reduced the attraction of pedicled flaps to the lower extremity, free flaps became a serious alternative. However, in consideration of the individual patient demand pedicled flaps to the lower extremity still have their eligibility and can be superior to free flaps in selected cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0043-124091DOI Listing
February 2019

A Molecular View of Plant Local Adaptation: Incorporating Stress-Response Networks.

Annu Rev Plant Biol 2019 Feb 20. Epub 2019 Feb 20.

Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA; email:

Ecological specialization in plants occurs primarily through local adaptation to different environments. Local adaptation is widely thought to result in costly fitness trade-offs that result in maladaptation to alternative environments. However, recent studies suggest that such trade-offs are not universal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-arplant-050718-100114DOI Listing
February 2019

Molecular Interactions Between Plants and Insect Herbivores.

Annu Rev Plant Biol 2019 Feb 20. Epub 2019 Feb 20.

Department of Plant Molecular Biology, University of Lausanne, 1015 Lausanne, Switzerland; email:

Diverse molecular processes regulate the interactions between plants and insect herbivores. Here, we review genes and proteins that are involved in plant-herbivore interactions and discuss how their discovery has structured the current standard model of plant-herbivore interactions. Plants perceive damage-associated and, possibly, herbivore-associated molecular patterns via receptors that activate early signaling components such as Ca, reactive oxygen species, and MAP kinases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-arplant-050718-095910DOI Listing
February 2019

International Divergence in Gene Patenting.

Annu Rev Genomics Hum Genet 2019 Feb 20. Epub 2019 Feb 20.

Centre for IT and IP Law, KU Leuven, 3000 Leuven, Belgium.

This review explores the recent divergence in international patent law relating to the patenting of genes and related subject matter. This divergence stems primarily from decisions of the highest courts in the United States and Australia on the eligibility of patent claims relating to the BRCA gene sequences. Patent offices, courts, and policy makers have struggled for many years to clearly articulate the bounds of patent claims on isolated and synthetic DNA and related products and processes, including methods for their use in genetic diagnostics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-genom-083118-015112DOI Listing
February 2019

Local Administration of Magnesium Promotes Meniscal Healing Through Homing of Endogenous Stem Cells: A Proof-of-Concept Study.

Am J Sports Med 2019 Feb 20:363546518820076. Epub 2019 Feb 20.

Department of Orthopaedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background:: Although many strategies have been developed to modify the biological and biomechanical environment of the meniscal suture repair to improve the chances of healing, the failure rates remain high. Thus, new methods to promote meniscal regeneration and repair are needed.

Hypothesis:: Administration of magnesium (via a repair using magnesium stitches) might enhance recruitment and adherence of endogenous stem cells to the site of the lesion, thereby promoting in situ meniscal regeneration and chondroprotective functions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0363546518820076DOI Listing
February 2019

Hierarchical Microchannel Architecture in Chitosan/Bioactive Glass Scaffolds via Electrophoretic Deposition Positive-Replica.

J Biomed Mater Res A 2019 Feb 20. Epub 2019 Feb 20.

Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Milano, Italy.

One of the main challenges in the design of scaffolds for cortical bone regeneration is mimicking the highly oriented, hierarchical structure of the native tissue in an efficient, simple, and consistent way. As a possible solution to this challenge, positive replica based on electrophoretic deposition (EPD) was here evaluated as a technique to produce organic/inorganic scaffolds with oriented micro-porosities mimicking Haversian canals diameter and spacing. Two different sizes of 45S5 bioactive glass (BG) powders were chosen as inclusions and loaded in a chitosan matrix via EPD on micro-patterned cathodes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36660DOI Listing
February 2019

Blastemal Predominant Type Wilms Tumors in Japan: Japan Children's Cancer Group.

Pediatr Int 2019 Feb 20. Epub 2019 Feb 20.

Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.

Background: Persistence of blastemal components after chemotherapy is a marker of poor outcome in Wilms tumor. Recent reports from local Japanese areas have described prechemotherapy blastemal predominant type Wilms tumor to be also a risk factor for relapse. However, significance of blastemal predominant WT remains to be evaluated in a larger study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ped.13811DOI Listing
February 2019

CARDIAC-SPECIFIC OVEREXPRESSION OF CAVEOLIN-3 PRESERVES T-TUBULAR I DURING HEART FAILURE IN MICE.

Exp Physiol 2019 Feb 20. Epub 2019 Feb 20.

School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK.

New Findings: What is the central question of this study? Overexpression of caveolin-3 (Cav-3 OE) appears to protect the heart against many of the features of heart failure (HF) normally observed in vivo. The present study investigates the cellular basis of this protection. What is the main finding and its importance? Cav-3 OE has little effect in normal ventricular myocytes but reduces cellular hypertrophy and preserves t-tubular I but not local t-tubular Ca release, in HF induced by pressure-overload in mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/EP087304DOI Listing
February 2019

Undiagnosed delirium is frequent and difficult to predict: Results from a prevalence survey of a tertiary hospital.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Department of Medicine and Aged Care, The Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.

Aims And Objectives: To study the prevalence and determinants of undiagnosed delirium in a tertiary hospital.

Background: Delirium is a common inpatient condition. It is frequently undiagnosed in a variety of settings, but determinants of undiagnosed delirium are largely unknown, and the frequency of undiagnosed delirium across all inpatient units is uncertain. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jocn.14833
Publisher Site
http://dx.doi.org/10.1111/jocn.14833DOI Listing
February 2019
2 Reads

Evaluation of pay-for-release conservation incentives for unintentionally caught threatened species.

Conserv Biol 2019 Feb 20. Epub 2019 Feb 20.

Biological Sciences, University of Windsor, 401 Sunset Avenue, Windsor, ON, N9B 3P4, Canada.

In the developing world, the exploitation of threatened species jeopardizes their permanence in the wild. Because not all captures are intentional, for instance when capture methods have low selectivity, pressure on these species may be lessened by releasing living incidentally caught animals. However, it is often unrealistic to expect people to voluntarily do so because it means foregoing the benefits of resource extraction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cobi.13300DOI Listing
February 2019

Localized synovial sarcoma: A single institutional study of 191 patients with a minimum follow-up of 5 years for survivors.

J Surg Oncol 2019 Feb 20. Epub 2019 Feb 20.

Oncology Service, Royal Orthopaedic Hospital, Birmingham, United Kingdom.

Purpose: Factors affecting long-term outcomes of synovial sarcoma (SS) remain unknown. Here, we aimed to investigate the long-term oncological outcomes and prognostic factors in a large group of patients with surgically-treated localized SS.

Patients And Methods: Between 1980 and 2011, 191 patients (94 males and 97 females) were treated at a single hospital with a minimum follow-up of 5 years for survivors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25417DOI Listing
February 2019

Density of bone metastatic lesions increases after radiotherapy in patients with breast cancer.

J Radiat Res 2019 Feb 20. Epub 2019 Feb 20.

Department of Radiation Oncology, 307 Hospital of People's Liberation Army, Beijing, China.

The aim of this study was to assess local response to radiotherapy (RT) in a quantitative manner by evaluating the bone density of metastases. Spinal and pelvic bone metastases in 44 patients with breast cancer who were treated between May 2010 and December 2016 were retrospectively assessed. Bone density values of irradiated and unirradiated bone metastases before, 1-3 months after, 4-6 months after, and 7-9 months after RT were compared. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jrr/rry098DOI Listing
February 2019

Secondary contact between diverged host lineages entails ecological speciation in a European hantavirus.

PLoS Biol 2019 Feb 20;17(2):e3000142. Epub 2019 Feb 20.

Institute of Ecology and Evolution, University of Bern, Switzerland.

The diversity of viruses probably exceeds biodiversity of eukaryotes, but little is known about the origin and emergence of novel virus species. Experimentation and disease outbreak investigations have allowed the characterization of rapid molecular virus adaptation. However, the processes leading to the establishment of functionally distinct virus taxa in nature remain obscure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.3000142DOI Listing
February 2019

Diagnostic and Management Options of Osteoblastoma in the Spine.

Med Sci Monit 2019 Feb 20;25:1362-1372. Epub 2019 Feb 20.

Department of Bone and Musculoskeletal Tumor Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China (mainland).

BACKGROUND Osteoblastoma is a rare, benign, osteolytic neoplasm commonly found in the spine in early adulthood. Here, we review the clinical characteristics, radiographic findings, and surgical management of patients with spinal osteoblastoma. MATERIAL AND METHODS Thirteen patients with osteoblastoma who underwent surgery at our institute from June 2008 to November 2017 were enrolled in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913666DOI Listing
February 2019

Assessing the Role of Caste/Ethnicity in Predicting Menstrual Knowledge, Attitudes, and Practices in Nepal.

Glob Public Health 2019 Feb 20:1-14. Epub 2019 Feb 20.

a Department of Behavioral and Community Health Sciences , Graduate School of Public Health, University of Pittsburgh , Pittsburgh , PA, USA.

Menstruation is a natural, physiological process, but it can be a challenging experience for millions of women around the world. In Nepal, a geographically small yet diverse country of 125 caste/ethnic groups, understanding how caste/ethnicity impacts menstrual health is critical for developing context-specific interventions to improve women's health. A community-based, cross-sectional survey was conducted with 679 women and girls between the ages of 13-51 from the country's most populous castes/ethnic groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17441692.2019.1583267DOI Listing
February 2019

Volitional control of single-electrode high gamma local field potentials (LFPs) by people with paralysis.

J Neurophysiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Neuroscience, Brown University, United States.

Intracortical brain-computer interfaces (BCIs) can enable individuals to control effectors, such as a computer cursor, by directly decoding the user's movement intentions from action potentials and local field potentials (LFPs) recorded within the motor cortex. However, the accuracy and complexity of effector control achieved with such "biomimetic" BCIs will depend on the degree to which the intended movements used to elicit control modulate the neural activity. In particular, channels that do not record distinguishable action potentials and only record LFP modulations may be of limited use for BCI control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/jn.00131.2018DOI Listing
February 2019

Healthy Retail as a Strategy for Improving Food Security and the Built Environment in San Francisco.

Am J Public Health 2019 Feb;109(S2):S137-S140

Meredith Minkler, is with the School of Public Health, University of California Berkeley. Jessica Estrada is with and Susana Hennessey-Lavery was with the San Francisco Department of Public Health, Community Health Equity and Promotion Branch, San Francisco, CA. Shelley Dyer is with the Tenderloin Neighborhood Development Corporation, Tenderloin Healthy Corner Store Coalition, San Francisco. Patricia Wakimoto is with the Nutrition Policy Institute, University of California, Davis. Jennifer Falbe is with the Human Development and Family Studies Unit, Department of Human Ecology, College of Agricultural and Environmental Sciences, University of California, Davis.

In low-income neighborhoods without supermarkets, lack of healthy food access often is exacerbated by the saturation of small corner stores with tobacco and unhealthy foods and beverages. We describe a municipal healthy retail program in San Francisco, California, focusing on the role of a local coalition in program implementation and outcomes in the city's low income Tenderloin neighborhood. By incentivizing selected corner stores to become healthy retailers, and through community engagement and cross-sector partnerships, the program is seeing promising outcomes, including a "ripple effect" of improvement across nonparticipating neighborhood stores. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2105/AJPH.2019.305000DOI Listing
February 2019

Spatial mapping of local density variations in two-dimensional electron systems using scanning photoluminescence.

Nano Lett 2019 Feb 20. Epub 2019 Feb 20.

We have developed a scanning photoluminescence technique that can directly map out the local two-dimensional electron densities with a relative accuracy of ~2.2×10 cm. The validity of this approach is confirmed by the observation of the expected density gradient in a high-quality GaAs quantum well sample that was not rotated during the molecular beam epitaxy of its spacer layer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.nanolett.8b05047DOI Listing
February 2019

[Levels of sex hormones, sex hormone binding globulin, antisperm antibodies and dopamine in postmanopausal women of nomadic and settled aboriginal and local caucasoid populations of the arctic territories.]

Klin Lab Diagn 2018 ;63(12):761-767

State institution YNAO «Scientific center of Arctic research», 629730, Nadym, Russia.

Positive changes in the society led to an improvement in quality and lifetime; as a result the menopause in women lengthens much longer, in light of this the relevance of studying hormonal changes increases, especially among the representatives of different groups living in the Arctic territories. The study was carried out on 138 women who included nomadic and settled aboriginal and local Caucasoid postmenopausal populations, permanently residing in the Arctic territories of Russia. The greatest difference in the studied blood indicators was shown between the local Caucasoid and aboriginal population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18821/0869-2084-2018-63-12-761-767DOI Listing
January 2018

[The vascular access of hemodialysis patients - What should the primary care physician know about ?]

Rev Med Suisse 2019 Feb;15(639):439-443

Service de chirurgie thoracique, Département Cœur-Vaisseaux, CHUV, 1011 Lausanne.

The most frequent dialysis modality in Switzerland is hemodialysis. Patients need a proper vascular access for this modality. There are three types of vascular access for hemodialysis : arteriovenous fistula, arteriovenous graft and central venous catheters. Read More

View Article

Download full-text PDF

Source
February 2019

NetSurfP-2.0: Improved prediction of protein structural features by integrated deep learning.

Proteins 2019 Feb 20. Epub 2019 Feb 20.

Department of Bio and Health Informatics, Technical University of Denmark, Kgs. Lyngby, Denmark.

The ability to predict local structural features of a protein from the primary sequence is of paramount importance for unravelling its function in absence of experimental structural information. Two main factors affect the utility of potential prediction tools: their accuracy must enable extraction of reliable structural information on the proteins of interest, and their runtime must be low to keep pace with sequencing data being generated at a constantly increasing speed. Here, we present NetSurfP-2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prot.25674DOI Listing
February 2019

Sensitivity analyses for average treatment effects when outcome is censored by death in instrumental variable models.

Stat Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Statistics, Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania.

Two problems that arise in making causal inferences for nonmortality outcomes such as bronchopulmonary dysplasia (BPD) are unmeasured confounding and censoring by death, ie, the outcome is observed only when subjects survive. In randomized experiments with noncompliance and no censoring by death, instrumental variable (IV) methods can be used to control for the unmeasured confounding. But, when there is censoring by death, the average causal treatment effect cannot be identified under usual assumptions but can be studied for a specific subpopulation by using sensitivity analysis with additional assumptions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/sim.8117DOI Listing
February 2019

Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease.

JAMA Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Harvard Medical School, Boston, Massachusetts.

Importance: Extramammary Paget disease (EMPD), a rare intraepithelial adenocarcinoma, poses a therapeutic challenge with high postoperative recurrence rates and a limited number of effective local treatment options.

Objective: To describe the use and efficacy of a topical combination of fluorouracil and calcipotriene as a palliative therapy for refractory EMPD.

Design, Setting, And Participants: This retrospective case series of 3 women with recurrent, refractory EMPD was conducted at Beth Israel Deaconess Medical Center, Boston, Massachusetts and Washington University School of Medicine, St Louis, Missouri. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamadermatol.2018.4793DOI Listing
February 2019

Spatial analysis of intentional homicides in João Pessoa, Paraíba, Brazil, 2011-2016.

Epidemiol Serv Saude 2019 Feb 18;28(1):e2018184. Epub 2019 Feb 18.

Secretaria de Estado de Segurança Pública e Defesa Social da Paraíba, Assessoria de Ações Estratégicas, João Pessoa, PB, Brasil.

Objective: to describe spatial patterns of intentional homicides in João Pessoa, Paraíba, Brazil, 2011-2016.

Methods: this was an ecological study using census tracts as units of analysis; the study used data on intentional homicides of victims living in João Pessoa obtained by cross-checking Mortality Information System SIM information with Public Security information; mortality coefficients were calculated for the whole period and its triennia and were later smoothed using the local empirical Bayesian method; spatial autocorrelation techniques were applied to the smoothed coefficients which were using Moran's spatial statistics.

Results: significant spatial autocorrelation was detected for the period as a whole I=0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5123/S1679-49742019000100003DOI Listing
February 2019

[Access to public physical activity programs in Brazil: National Health Survey, 2013].

Cad Saude Publica 2019 Feb 18;35(2):e00008618. Epub 2019 Feb 18.

Universidade Federal de Pelotas, Pelotas, Brasil.

The article sought to describe awareness of public physical activity programs, practice of physical activity in public programs and barriers related to non-participation in these programs in a national representative sample according to sex, age, skin color, income, state and having been visited by a family health team (EqSF, in Portuguese) in the previous year. This is a cross-sectional survey with data from the Brazilian National Health Survey, 2013. We carried out descriptive analyses using the distribution of relative frequencies and their respective 95% confidence intervals, weighted in the sample design. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0102-311X00008618DOI Listing
February 2019

Ethics in humanitarian efforts: giving due credit to the local team.

Cardiol Young 2019 Feb;29(2):195-199

William Novick Global Cardiac Alliance,Memphis,TN,USA.

Background: It has become increasingly apparent that only the truly effective humanitarian work emphasises empowering local practitioners. One problem, though, is that we are often seen as the "experts" who have come to "save" the children. This perception may adversely affect the confidence in the country's own providers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1047951118002081DOI Listing
February 2019

ICARUSS: An effective model for risk factor management in stroke survivors.

Int J Stroke 2019 Feb 20:1747493019830582. Epub 2019 Feb 20.

5 Sir Charles Gairdner Hospital, Nedlands, Australia.

Background And Purpose: After an initial stroke, the risk of recurrent stroke is high. Models that implement best-practice recommendations for risk factor management in stroke survivors to prevent stroke recurrence remain elusive. We examined a model which focuses on vascular risk factor management to prevent stroke recurrence in survivors returning to their primary care physicians. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1747493019830582
Publisher Site
http://dx.doi.org/10.1177/1747493019830582DOI Listing
February 2019
1 Read

A second dose of a measles-mumps-rubella vaccine administered to healthy four-to-six-year-old children: a phase III, observer-blind, randomized, safety and immunogenicity study comparing GSK MMR and MMR II with and without DTaP-IPV and varicella vaccines co-administration.

Authors:

Hum Vaccin Immunother 2019 Feb 20:1-14. Epub 2019 Feb 20.

a See Contributors section.

In many countries, a second dose of a combined measles, mumps, and rubella (MMR) vaccine is recommended at 4-6 years of age - similarly to the booster of diphtheria, tetanus, acellular pertussis, and inactivated polio vaccine (DTaP-IPV) and the second dose of varicella vaccine (VV). Vaccine co-administration is generally encouraged if no interferences exist among the vaccines. This phase IIIa, randomized, controlled trial (NCT01621802) evaluated the immunogenicity and safety of MMR-RIT (Priorix, GSK) when given as a second dose with or without co-administration of DTaP-IPV and VV, using MMR II (M-M-R II, Merck & Co Inc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21645515.2018.1554971DOI Listing
February 2019

IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis.

Am J Physiol Renal Physiol 2019 Feb 20. Epub 2019 Feb 20.

Children's National Medical Center, United States.

Chemotherapy-induced hemorrhagic cystitis is characterized by bladder pain and voiding dysfunction caused by hemorrhage and inflammation. Novel therapeutic options to treat hemorrhagic cystitis are needed. We previously reported that systemic administration of the Schistosomiasis haematobium-derived protein H-IPSE (IL-4-inducing principle from Schistosoma mansoni eggs), is superior to 3 doses of MESNA in alleviating hemorrhagic cystitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00468.2018DOI Listing
February 2019

V-shaped active plasmonic meta-polymers.

Nanoscale 2019 Feb 20. Epub 2019 Feb 20.

Department of Physics, Indian Institute of Science Education and Research Pune, Pune 411008, India.

We report the design and fabrication of V-shaped plasmonic meta-polymers on a glass substrate or silicon wafer using a surface functionalization approach. The efficacy of the assembly method is examined by analyzing the surface enhanced Raman scattering by an individual V-shaped antenna experimentally and using computational simulations to determine the polarization dependence of local electromagnetic field enhancement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8nr10034aDOI Listing
February 2019

At a high dose even partially degraded beta-glucan with decreased solubility significantly reduced the glycaemic response to bread.

Food Funct 2019 Feb 20. Epub 2019 Feb 20.

Nofima AS, Norwegian Institute of Food, Fisheries and Aquaculture Research, Ås, Norway.

Cereal beta-glucan can reduce post-prandial glycaemic responses, which makes it an interesting ingredient to improve the health impact of bread, a staple food with a high glycaemic index (GI). Here we compare the ability of different wheat-based breads prepared with oat bran concentrate and barley flour and a Norwegian type of soft wrap (lompe) for their ability to reduce glycaemic responses in healthy adults. Both breads with the highest beta-glucan content (3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8fo02098aDOI Listing
February 2019

The impact of Balint work on alexithymia, perceived stress, perceived social support and burnout among physicians working in palliative care: a longitudinal study.

Int J Occup Med Environ Health 2019 Feb 20. Epub 2019 Feb 20.

University of Medicine and Pharmacy "Carol Davila," Bucharest, Romania (Faculty of Medicine, Department of Medical Psychology).

Objectives: Physicians working with palliative patients have a substantial risk of emotional exhaustion because of their daily confrontation with suffering and death. Common concerns include alexithymia, high stress, low perceived social support and a greater burnout risk. This longitudinal study aimed to evaluate the effectiveness of Balint training in preventing the development of these symptoms in these medical professionals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13075/ijomeh.1896.01302DOI Listing
February 2019

Contribution of In Vivo and In Vitro Testing for The Diagnosis of Local Allergic Rhinitis.

J Investig Allergol Clin Immunol 2019 Feb;29(1):46-48

Serviço de Imunoalergologia, Centro Hospitalar de Lisboa Norte, Lisbon, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18176/jiaci.0321DOI Listing
February 2019

Neuronal spiking activity highlights a gradient of epileptogenicity in human tuberous sclerosis lesions.

Clin Neurophysiol 2019 Jan 30;130(4):537-547. Epub 2019 Jan 30.

Centre de Recherche Cerveau et Cognition, Université de Toulouse, Université Paul Sabatier Toulouse, Toulouse F-31330, France; Centre National de la Recherche Scientifique, CerCo, UMR 5549, Toulouse F-31052, France.

Objective: The mechanisms underlying epileptogenicity in tuberous sclerosis complex (TSC) are poorly understood.

Methods: We analysed neuronal spiking activity (84 neurons), fast ripples (FRs), local field potentials and intracranial electroencephalogram during interictal epileptiform discharges (IEDs) in the tuber and perituber of a patient using novel hybrid electrodes equipped with tetrodes.

Results: IEDs were recorded in the tuber and perituber. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinph.2018.12.013DOI Listing
January 2019

Evaluation of photosynthetic light integration by microalgae in a pilot-scale raceway reactor.

Bioresour Technol 2019 Feb 6;280:404-411. Epub 2019 Feb 6.

Department of Chemical Engineering, Universidad de Almería, Spain. Electronic address:

The improvement of photosynthetic efficiency in a 100 m raceway reactor by enhancement of light regime to which the cells are exposed is here reported. From Computational Fluid Dynamics it was calculated that the light exposure times ranged from 0.4 to 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biortech.2019.02.032DOI Listing
February 2019

The effect of estrone and estradiol on the expression of the orexin/hypocretin system in the porcine uterus during early pregnancy.

Domest Anim Endocrinol 2019 Jan 4;68:11-24. Epub 2019 Jan 4.

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719 Olsztyn, Poland. Electronic address:

Orexin A and B (OXA, OXB) are hypothalamic neuropeptides acting via two receptors, type 1 (OX1R) and 2 (OX2R). Orexins, also known as hypocretins, take part in a common endocrine system regulating metabolism and reproductive functions. Changes in the orexin system expression during the estrous cycle and pregnancy suggest dependence on the local hormonal milieu. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.domaniend.2018.12.008DOI Listing
January 2019

Human health risk assessment of groundwater arsenic contamination in Jinghui irrigation district, China.

J Environ Manage 2019 Feb 19;237:163-169. Epub 2019 Feb 19.

School of Land Engineering, Chang'an University, No. 126 Yanta Road, Xi'an, 710054, Shaanxi, China. Electronic address:

The groundwater is an important route of human exposure to kinds of contaminants. This study was carried out to investigate the occurrence and spatial distribution of groundwater arsenic in the Jinghui irrigation district in Shaanxi Province, China. The water contamination was assessed for drinking purposes by comparing it to national guidelines, and the impacts of arsenic on human health were quantified using the health risk assessment model recommended by the USEPA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2019.02.067DOI Listing
February 2019

Negotiating jurisdictional boundaries in response to new genetic possibilities in breast cancer care: The creation of an 'oncogenetic taskscape'.

Soc Sci Med 2019 Feb 13;225:26-33. Epub 2019 Feb 13.

Ethox Centre and Wellcome Centre for Ethics and Humanities, Nuffield Department of Population Health, Big Data Institute University of Oxford, UK.

Changes in the nature and structure of healthcare pathways have implications for healthcare professionals' jurisdictional boundaries. The introduction of treatment focused BRCA1 and 2 genetic testing (TFGT) for newly diagnosed patients with breast cancer offers a contemporary example of pathway change brought about by technological advancements in gene testing and clinical evidence, and reflects the cultural shift towards genomics. Forming part of an ethnographically informed study of patient and practitioner experiences of TFGT at a UK teaching hospital, this paper focuses on the impact of a proposal to pilot a mainstreamed TFGT pathway on healthcare professionals' negotiations of professional jurisdiction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.socscimed.2019.02.020DOI Listing
February 2019

Spatial and temporal risk quotient based river assessment for water resources management.

Environ Pollut 2019 Feb 8;248:133-144. Epub 2019 Feb 8.

Sustainable Developments in Civil Engineering Research Group, Faculty of Civil Engineering, Ton Duc Thang University, Ho Chi Minh City, Viet Nam. Electronic address:

Malaysia depends heavily on rivers as a source for water supply, irrigation, and sustaining the livelihood of local communities. The evolution of land use in urban areas due to rapid development and the continuous problem of illegal discharge have had a serious adverse impact on the health of the country's waterways. Klang River requires extensive rehabilitation and remediation before its water could be utilised for a variety of purposes. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02697491183408
Publisher Site
http://dx.doi.org/10.1016/j.envpol.2019.02.011DOI Listing
February 2019
1 Read

Drivers of the fatal drug epidemic.

J Health Econ 2019 Jan 14;64:25-42. Epub 2019 Jan 14.

Frank Batten School of Leadership & Public Policy, University of Virginia, 235 McCormick Road, P.O. Box 400893, Charlottesville, VA, 22904-4893, United States. Electronic address:

This study examines the contributions of the medium-run evolution of local economies and of changes in the "drug environment' in explaining county-level changes in drug and related mortality rates from 1999 to 2015. A primary finding is that drug mortality rates did increase more in counties experiencing relative economic decline than in those with more robust growth, but that the relationship is weak and mostly accounted for by confounding factors. In the preferred estimates, less than one-tenth of the rise in drug and opioid-involved fatality rates is explained and the contribution is even smaller, quite possibly zero, when allowing for plausible selection on unobservables. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhealeco.2019.01.001DOI Listing
January 2019

Metabolic response of bacteria to elevated concentrations of glyphosate-based herbicide.

Ecotoxicol Environ Saf 2019 Feb 20;173:373-380. Epub 2019 Feb 20.

Institute of Microbiology and Biotechnology, University of Latvia, Riga, Latvia.

Glyphosate-based herbicides (GBHs) are the most widespread commonly used broad-spectrum herbicides that contaminate soils and waters, are toxic to bacteria, plants and animals, and have been classified as 'probably carcinogenic to humans' by the International Agency for Research on Cancer in 2015. Particular soil bacteria and fungi can degrade GBHs, hence, search for new GBH-degrading strains or microbial consortia, effective under specific growth conditions and local environment, seems to be a promising solution for bio-remediation of glyphosate-contaminated environment. Consequently, there is a need for rapid and informative methods to evaluate the GBH-induced changes of the metabolic pathways in cells, that may serve as indicators of GBH-degrading potential. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2019.02.045DOI Listing
February 2019

Mechanical analysis of femoral stress-riser fractures.

Clin Biomech (Bristol, Avon) 2019 Feb 14;63:10-15. Epub 2019 Feb 14.

Department of Orthopaedic Surgery, Gangnam Sacred Heart Hospital, Hallym University School of Medicine, Seoul, Republic of Korea. Electronic address:

Background: A stress-riser fracture develops when stress in an object is higher than that in the surrounding material. The aim of this retrospective study was to evaluate all consecutive femoral stress-riser fractures during a period of >10 years and to verify high-risk factors by using mechanical analysis.

Methods: Forty clinical fractures caused by local stress concentration in the femoral cortical bone were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinbiomech.2019.02.004DOI Listing
February 2019

Effects of miR-181a-5p abnormal expression on zebrafish (Danio rerio) vascular development following triclosan exposure.

Chemosphere 2019 Feb 11;223:523-535. Epub 2019 Feb 11.

Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, China, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. Electronic address:

Triclosan (TCS), one of the important bactericides, is widely used in personal care products, and its chronic exposure leads to severe toxic effects on the growth and development of blood vessels in zebrafish (Danio rerio). Herein, we screened out three differentially expressed miRNAs (miR-181a-5p, miR-132-3p and miR-128-3p) by sequencing and qRT-PCR analyses of 4-96-hpf TCS-exposed zebrafish, among which miR-181a-5p was found to regulate many signaling pathways involved in fatty acid biosynthesis and phosphatidylimositol signaling systems. By O-dianisidine staining, TCS-exposure resulted in decreased distribution of red blood cells and induced blood hypercoagulable state and thrombotic effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.02.038DOI Listing
February 2019

Trace metals in green sea turtles (Chelonia mydas) inhabiting two southern California coastal estuaries.

Chemosphere 2019 Feb 8;223:342-350. Epub 2019 Feb 8.

Department of Biological Sciences, California State University, Long Beach, USA.

Foraging aggregations of east Pacific green sea turtles (Chelonia mydas) inhabit the Seal Beach National Wildlife Refuge (SBNWR) and San Diego Bay (SDB), two habitats in southern California, USA, located near urbanized areas. Both juvenile and adult green turtles forage in these areas and exhibit high site fidelity, which potentially exposes green turtles to anthropogenic contaminants. We assessed 21 trace metals (TM) bioaccumulated in green turtle scute and red blood cell (RBC) samples collected from SBNWR (n = 16 turtles) and SDB (n = 20 turtles) using acid digestion and inductively coupled plasma mass spectrometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.01.107DOI Listing
February 2019

Structure, dissolution, and plant uptake of ferrous/zinc phosphates.

Chemosphere 2019 Feb 12;223:310-318. Epub 2019 Feb 12.

National Nanotechnology Center, National Science and Technology Development Agency, 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathum Thani, 12120, Thailand; AFRS(T), The Royal Society of Thailand, Sanam Sueapa, Dusit, Bangkok, 10300, Thailand. Electronic address:

Development of slow release fertilizers by tuning dissolution kinetics can reduce the environmental impact of (micro) nutrients added to crops. Mixed metal compounds may have different dissolution kinetics and plant uptake than single metal compounds. In this study, mixed Fe(II)/Zn(II) phosphates (0-100 at% Zn) were prepared by aqueous precipitation and their structural characteristics and dissolution kinetics in a sand column were measured as model for divalent metal and phosphate release in soil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.02.024DOI Listing
February 2019
1 Read

Evidence for the widespread occurrence of short- and medium-chain chlorinated paraffins in fish collected from the Rhône River basin (France).

Chemosphere 2019 Feb 13;223:232-239. Epub 2019 Feb 13.

CNRS, University of Bordeaux, EPOC, UMR 5805, F-33400, Talence, France.

Chlorinated paraffins (CPs) are high-volume chemicals used in numerous industrial applications. Their quantitative analysis is extremely challenging and this work presents the optimization of an analytical method based on gas chromatography hyphenated with electron capture negative ionization time-of-flight high-resolution mass spectrometry (GC-ECNI-TOF HRMS) for the simultaneous determination of short-chain and medium-chain CPs (SCCPs and MCCPs, respectively) in fish tissues (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.02.069DOI Listing
February 2019

Decoupling the Roles of Cell Shape and Mechanical Stress in Orienting and Cueing Epithelial Mitosis.

Cell Rep 2019 Feb;26(8):2088-2100.e4

Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, M13 9PT, UK. Electronic address:

Distinct mechanisms involving cell shape and mechanical force are known to influence the rate and orientation of division in cultured cells. However, uncoupling the impact of shape and force in tissues remains challenging. Combining stretching of Xenopus tissue with mathematical methods of inferring relative mechanical stress, we find separate roles for cell shape and mechanical stress in orienting and cueing division. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.01.102DOI Listing
February 2019

Wound Coverage Options for Soft Tissue Defects Following Calcaneal Fracture Management (Operative/Surgical).

Clin Podiatr Med Surg 2019 Apr 12;36(2):323-337. Epub 2018 Dec 12.

Plastic Reconstructive and Orthopaedic Surgery, University of Pennsylvania Health System, Perelman Center for Advanced Medicine, 3400 Civic Center Boulevard, South Pavilion, 1st Floor, Philadelphia, PA 19104, USA.

Soft tissue defects and wound healing complications related to calcaneus fractures may result in significant morbidity. The management of these soft tissue complications requires following reconstructive principles that provide the requisites for preservation of the injured limb and the maximization of function. Soft tissue complications are addressed with methods that commensurate with the degree of injury, ranging from local wound care to free flap reconstruction. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08918422183009
Publisher Site
http://dx.doi.org/10.1016/j.cpm.2018.10.012DOI Listing
April 2019
1 Read

Expression levels of HSP70 and CPT-1 in three local breeds of chickens reared under normal or heat stress conditions after the introduction of the naked neck gene.

J Therm Biol 2019 Feb 17;80:113-118. Epub 2018 Dec 17.

Poultry Production Department, Faculty of Agriculture, Ain Shams University, Cairo, Egypt.

The naked neck gene was introduced by crossbreeding into Egyptian breeds to improve body weight. Expression levels of HSP70 and CPT-1 were used to assess the heat tolerance of three Egyptian local breeds (Fayoumi, Dandarawi and Sinai) with and without the naked neck gene and under normal and heat stress conditions. There were two genotypes from each breed that had the same genetic origin (the naked neck and normal plumage genotypes). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtherbio.2018.12.018DOI Listing
February 2019

Raman spectroscopy of diesel and gasoline engine-out soot using different laser power.

J Environ Sci (China) 2019 May 14;79:74-80. Epub 2018 Nov 14.

Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409, USA. Electronic address:

We studied engine-out soot samples collected from a heavy-duty direct-injection diesel engine and port-fuel injection gasoline spark-ignition engine. The two types of soot samples were characterized using Raman spectroscopy with different laser powers. A Matlab program using least-square-method with trust-region-reflective algorithm was developed for curve fitting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jes.2018.11.001DOI Listing
  • Page 1 of 14825