733,497 results match your criteria Local & Regional Anesthesia [Journal]


[Progressive pseudorheumatoid dysplasia misdiagnosed as ankylosing spondylitis: a case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1112-1116

Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.

In this study, we reported a case of progressive pseudorheumatoid dysplasia in Peking University Third Hospital. A 56-year-old male patient presented with hip joint pain for more than 40 years and multiple joints pain with limitation of movements of these joints for 28 years. This patient suffered from joint pain and impaired range of motion of the hip, knee, elbow and shoulder gradually, associated with difficulty in walking and inability to take care of himself. Read More

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December 2018

[Application of artificial ligament in treatment of lower abdominal wall reconstruction after pubic tumor resection].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1049-1052

Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing 100044, China.

Objective: For patients who had hemipelvectomies involving the resection of a portion or the whole of the pubis, bony reconstruction was not recommended commonly. However, the soft tissue reconstruction of the lower abdominal wall may benefit these patients. The object of the study was to determine the clinical effect of lower abdominal wall reconstruction with LARS ligament after pubic tumor resection interms of patient-reported and objective outcome. Read More

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December 2018

[Effects of integrin metalloproteinases on osteogenic differentiation].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):962-967

Department of Rheumatology and Immunology, China-Japan Friendship Hospital, Beijing 100029, China.

Objective: To study the effects of disintegrin and metalloproteinase (ADAM) 9, 15 and 17 on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs).

Methods: BMMSCs of ADAM9, ADAM15, ADAM17 conditional knockout mice and wild type mice (WT) were induced and cultured. Alkaline phosphatase (ALP) activity was measured by colorimetry, early osteogenic transcription factors Runx and Osterix were detected by Real-time PCR, and mineral formation was analyzed by alizarin red staining. Read More

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December 2018
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A case of ileus caused by ileal endometriosis with lymph node involvement.

Int J Surg Case Rep 2018 Dec 12;54:90-94. Epub 2018 Dec 12.

Department of Gastroenterological Surgery, Hiroshima Prefectural Hospital, Japan; Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Japan.

Introduction: Endometriosis is characterized by the presence of endometrial tissue outside the uterus. However, the presence of endometriotic lesions in extrauterine locations at the terminal ileum is unusual and a preoperative diagnosis of intestinal endometriosis has proved challenging.

Presentation Of Case: A 49-year-old woman visited a local hospital complaining chiefly of vomiting. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.066DOI Listing
December 2018

Endometriosis and cancer.

Free Radic Biol Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Obstetrics and Gynecology, Graduate School of Medicine, Nagoya University, Japan.

Endometriosis, characterized by the presence of extra-uterine endometrium, is a common gynecologic disorder in reproductive-age women. Although the detailed molecular mechanism of etiology remains unelucidated, recent studies have gradually revealed both genetic and epigenetic backgrounds of the development of endometriosis. In clinical practice, endometriosis has been recognized as a precursor lesion of several types of malignancies and endometriosis-associated carcinoma. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.015DOI Listing
December 2018

Pharmacokinetics of intra-articular vitamin D analogue calcipotriol in sheep and metabolism in human synovial and mesenchymal stromal cells.

J Steroid Biochem Mol Biol 2018 Dec 15. Epub 2018 Dec 15.

Cancer Research and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O.Box 8000 FI-90014, University of Oulu, Oulu, Finland; Rheumatology Unit, Department of Medicine, Oulu University Hospital and University of Oulu, MRC, Oulu, P.O. Box 10, 90029 OYS, Finland. Electronic address:

Calcipotriol (MC903) is a side chain analogue of the biologically active 1,25-dihydroxyvitamin D [1,25(OH)D]. Due to its anti-inflammatory and anti-proliferative effects on stromal cells, calcipotriol is a promising candidate for the local treatment of arthritis. In this preliminary work, we studied the pharmacokinetics and safety of calcipotriol after an IV (0. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2018.12.006DOI Listing
December 2018

Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer: A Critical Review.

Int J Radiat Oncol Biol Phys 2018 Dec 15. Epub 2018 Dec 15.

Department of Radiation Oncology, University of San Francisco, San Francisco, CA, USA.

Perineural invasion (PNI), the neoplastic invasion of nerves, is a common pathological finding in head and neck cancer that is associated with poor clinical outcomes. PNI is a histological finding of tumor cell infiltration and is distinct from perineural tumor spread (PNTS), which is macroscopic tumor involvement along a nerve extending from the primary tumor that is by definition more advanced, being radiologically or clinically apparent. Despite widespread acknowledgement of the prognostic significance of PNI/PNTS, the mechanisms underlying its pathogenesis remain largely unknown, and specific therapies targeting nerve invasion are lacking. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.12.009DOI Listing
December 2018

Oriented Cell Division: The Pull of the Pole.

Dev Cell 2018 Dec;47(6):686-687

Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada; Ted Rogers Centre for Heart Research, University of Toronto, Toronto, ON M5G 1M1, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

Cells are thought to divide along their longest axis. Now, two studies in Developmental Cell (Scarpa et al., 2018) and EMBO Journal (Finegan et al. Read More

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http://dx.doi.org/10.1016/j.devcel.2018.11.040DOI Listing
December 2018

Does the intake of ethanol affect oral absorption of poorly soluble drugs?

J Pharm Sci 2018 Dec 15. Epub 2018 Dec 15.

Department of Pharmacy, Uppsala University, BMC P.O. Box 580, SE-751 23 Uppsala, Sweden.

The presence of ethanol in gastrointestinal (GI) fluids may increase the solubility of poorly water-soluble drugs. This suggests that intake of ethanol with such compounds could result in increased drug absorption in the stomach and/or duodenum because of the greater concentration gradient present. To test this hypothesis, in vitro dissolution of two poorly soluble compounds (indomethacin and felodipine) was studied in simulated GI rat fluids in the presence or absence of ethanol. Read More

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http://dx.doi.org/10.1016/j.xphs.2018.12.006DOI Listing
December 2018

Anti-tumour necrosis factor biological therapies for the treatment of uveitic macular oedema (UMO) for non-infectious uveitis.

Cochrane Database Syst Rev 2018 Dec 18;12:CD012577. Epub 2018 Dec 18.

Academic Unit of Ophthalmology, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Non-infectious uveitis describes a heterogenous group of ocular disorders characterised by intraocular inflammation in the absence of infection. Uveitis is a leading cause of visual loss, most commonly due to uveitic macular oedema (UMO). Treatment is aimed at reducing disease activity by suppression of the intraocular inflammatory response. Read More

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http://dx.doi.org/10.1002/14651858.CD012577.pub2DOI Listing
December 2018

Farmers' preferred tree species and their potential carbon stocks in southern Burkina Faso: Implications for biocarbon initiatives.

PLoS One 2018 18;13(12):e0199488. Epub 2018 Dec 18.

Université du Faso (UFA), Ouagadougou, Burkina Faso.

The success of terrestrial carbon sequestration projects for rural development in sub-Saharan Africa lies in the (i) involvement of local populations in the selection of woody species, which represent the biological assets they use to meet their daily needs, and (ii) information about the potential of these species to store carbon. Although the latter is a key prerequisite, there is very little information available. To help fill this gap, the present study was undertaken in four pilot villages (Kou, Dao, Vrassan and Cassou) in Ziro Province, south-central Burkina Faso. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199488PLOS
December 2018

Local epigenomic state cannot discriminate interacting and non-interacting enhancer-promoter pairs with high accuracy.

PLoS Comput Biol 2018 Dec 18;14(12):e1006625. Epub 2018 Dec 18.

Department of Biomedical Engineering John Hopkins, Baltimore, MD, United States of America.

We report an experimental design issue in recent machine learning formulations of the enhancer-promoter interaction problem arising from the fact that many enhancer-promoter pairs share features. Cross-fold validation schemes which do not correctly separate these feature sharing enhancer-promoter pairs into one test set report high accuracy, which is actually arising from high training set accuracy and a failure to properly evaluate generalization performance. Cross-fold validation schemes which properly segregate pairs with shared features show markedly reduced ability to predict enhancer-promoter interactions from epigenomic state. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006625DOI Listing
December 2018

What role can unmanned aerial vehicles play in emergency response in the Arctic: A case study from Canada.

PLoS One 2018 18;13(12):e0205299. Epub 2018 Dec 18.

Qaujigiartiit Health Research Centre, Iqaluit, Canada.

This paper examines search and rescue and backcountry medical response constraints in the Canadian Arctic and potential for unmanned aerial vehicles (UAV) to aid in response and preparedness. Semi-structured interviews (n = 18) were conducted with search and rescue responders, Elders, and emergency management officials to collect data on current emergency response and potential for UAV use. UAV test flights (n = 17) were undertaken with community members. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205299PLOS
December 2018

Complete Excision of a Simple Dacryops Using Fibrin Sealant and Trypan Blue Mixture.

Ophthalmic Plast Reconstr Surg 2018 Dec 17. Epub 2018 Dec 17.

Division of Oculofacial Plastic and Reconstructive Surgery, Department of Ophthalmology, and.

A 69-year-old woman presented to the oculofacial plastic service with a painless superotemporal subconjunctival mass in the OS. Over the past year, the lesion had been progressively enlarging, resulting in horizontal diplopia with lateral gaze. Visual acuity was within normal limits with no evidence of optic neuropathy. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001283DOI Listing
December 2018

Antibiotic-Loaded Collagen Sponges in Clinical Treatment of Chronic Osteomyelitis: A Systematic Review.

J Bone Joint Surg Am 2018 Dec;100(24):2153-2161

Department of Orthopaedic Surgery (T.A.G.v.V., J.A.P.G., and J.J.C.A.) and Faculty of Health Medicine and Life Sciences (J.M.B.W.), Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands.

Background: Chronic osteomyelitis is caused by bacterial infection of the bone and is a major problem in orthopaedic surgery. Treatment of chronic osteomyelitis requires surgical debridement accompanied by local and systemic administration of antibiotics. A widely established biodegradable local antibiotic carrier is antibiotic-loaded collagen sponges (fleeces). Read More

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http://dx.doi.org/10.2106/JBJS.17.01140DOI Listing
December 2018

Local infiltration anaesthesia versus sciatic nerve and adductor canal block for fast-track knee arthroplasty: A randomised controlled clinical trial.

Eur J Anaesthesiol 2018 Dec 17. Epub 2018 Dec 17.

Joanna Kastelik and Michael Fuchs contributed equally to the article.

Background: Local infiltration anaesthesia (LIA) was introduced as an innovative analgesic procedure for enhanced recovery after primary total knee arthroplasty (TKA). However, LIA has never been compared with analgesia based on an adductor canal catheter and a single-shot sciatic nerve block.

Objective: To evaluate two analgesic regimens for TKA comparing mobility, postoperative pain and patient satisfaction. Read More

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http://dx.doi.org/10.1097/EJA.0000000000000929DOI Listing
December 2018

Surgical Technique for Nasal Cleft Repair.

Ann Plast Surg 2018 Dec 18. Epub 2018 Dec 18.

From the Department of Plastic, Reconstructive, and Hand Surgery, Hadassah University Medical Center, Jerusalem, Israel.

Background: Congenital nasal cleft is a very rare yet challenging deformity to reconstruct. Atypical craniofacial clefts that involve the nasal ala are designated as number 1 and number 2 under the Tessier classification system. These clefts typically present as notches in the medial one-third of either nasal ala and may be accompanied by a malpositioned cartilaginous framework. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001688DOI Listing
December 2018

Acquired Localized Hypertrichosis Following Pressure Garment and/or Silicone Therapy in Burn Patients.

Ann Plast Surg 2018 Dec 18. Epub 2018 Dec 18.

Ekol Hospital, Izmir, Turkey.

Hypertrichosis is characterized by excessive and abnormal hair growth anywhere on the skin and may develop after prolonged local irritation, such as application of a cast, injury, or a bite. Pressure garment/silicone therapy is often used to prevent hypertrophic scar formation. The adverse effects of gel sheet application include rash, skin breakdown, cessation of scar responsiveness, pruritus, contact dermatitis, and dry skin. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001686DOI Listing
December 2018

The immune podocyte.

Curr Opin Rheumatol 2018 Dec 17. Epub 2018 Dec 17.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus and is characterized by proteinuria and renal failure. Proteinuria is a marker of poor prognosis and is attributed to podocyte loss and dysfunction. It is often debated whether these cells are innocent bystanders or active participants in the pathogenesis of glomerulonephritis. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000578DOI Listing
December 2018

Food allergy: what it is and what it is not?

Authors:
Chen Hsing Lin

Curr Opin Gastroenterol 2018 Dec 17. Epub 2018 Dec 17.

Division of Allergy and Immunology, Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Purpose Of Review: Food allergy is defined as an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food. Food intolerance, certain gastrointestinal or systemic diseases are often confused with or mislabeled as food allergy because of symptomatic similarity and general improvement from food avoidance. The differences between these diseases are crucial. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000506DOI Listing
December 2018

Personalised Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis.

Am J Respir Crit Care Med 2018 Dec 18. Epub 2018 Dec 18.

Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.

Rationale: A subset of infants are hyper-susceptible to severe/acute viral bronchiolitis (AVB), for reasons incompletely understood.

Objectives: To characterise the cellular/molecular mechanisms underlying infant AVB in circulating cells/local airways tissues.

Methods: PBMC and nasal scrapings were obtained from infants (<18mths) and children (>18mths-5yrs) during AVB and post-convalescence. Read More

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http://dx.doi.org/10.1164/rccm.201804-0715OCDOI Listing
December 2018

Metaecosystem Dynamics of Marine Phytoplankton Alters Resource Use Efficiency along Stoichiometric Gradients.

Am Nat 2019 Jan 27;193(1):35-50. Epub 2018 Nov 27.

Metaecosystem theory addresses the link between local (within habitats) and regional (between habitats) dynamics by simultaneously analyzing spatial community ecology and abiotic matter flow. Here we experimentally address how spatial resource gradients and connectivity affect resource use efficiency (RUE) and stoichiometry in marine phytoplankton as well as the community composition at local and regional scales. We created gradostat metaecosystems consisting of five linearly interconnected patches, which were arranged either in countercurrent gradients of nitrogen (N) and phosphorus (P) supply or with a uniform spatial distribution of nutrients and which had either low or high connectivity. Read More

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http://dx.doi.org/10.1086/700835DOI Listing
January 2019

Tuning protein diffusivity with membrane tethers.

Biochemistry 2018 Dec 18. Epub 2018 Dec 18.

Diffusion is essential for biochemical processes because it dominates molecular movement on small scales. Enzymatic reactions, for example, require fast exchange of substrate and product molecules in the local environment of the enzyme to ensure efficient turnover. On larger spatial scales, diffusion of secreted signaling proteins is thought limit the spatial extent of tissue dif-ferentiation during embryonic development. Read More

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http://dx.doi.org/10.1021/acs.biochem.8b01150DOI Listing
December 2018

Sulfur isotope analysis of microcrystalline iron sulfides using SIMS imaging: Extracting local paleo-environmental information from modern and ancient sediments.

Rapid Commun Mass Spectrom 2018 Dec 18. Epub 2018 Dec 18.

Department of Earth & Planetary Sciences, Washington University in Saint Louis, St. Louis, MO, 63130, USA.

Rationale: Sulfur isotope ratio measurements of bulk sulfide from marine sediments have often been used to reconstruct environmental conditions associated with their formation. In-situ microscale spot analyses by secondary ion mass spectrometry (SIMS) and laser ablation multiple-collector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS) have been utilized for the same purpose. However, these techniques are not often suitable for studying small (≤10 μm) grains or for detecting intra-grain variability. Read More

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http://dx.doi.org/10.1002/rcm.8375DOI Listing
December 2018

Linking genes with ecological strategies in Arabidopsis thaliana.

J Exp Bot 2018 Dec 15. Epub 2018 Dec 15.

Institute of Botany, University of Cologne, Germany.

Arabidopsis thaliana is the most prominent model system in plant molecular biology and genetics. Although its ecology was initially neglected, collections of various genotypes revealed a complex population structure, with high levels of genetic diversity and substantial levels of phenotypic variation. This helped identify the genes and gene pathways mediating phenotypic change. Read More

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http://dx.doi.org/10.1093/jxb/ery447DOI Listing
December 2018

Mental health needs and services for migrants: An overview for primary care providers.

J Travel Med 2018 Dec 18. Epub 2018 Dec 18.

McGill University - Division de psychiatrie sociale et culturelle, CLSC Parc Extension 7085 Hutchison, Local 204.2, Montreal, Quebec H3N 1Y9, Canada.

Background: The objective of this article is to present an overview of the burden, spectrum of diseases, and risk factors for mental illness among subgroups of migrants, namely immigrants, refugees, and individuals with precarious legal status. This expert review summarizes some of the implications for primary care services in migrant receiving countries in the global North.

Methods: A broad literature review was conducted on the epidemiology of mental health disorder in migrants and refugee and on the available evidence on mental health services for this population focusing on key issues for primary care practitioners in high income countries. Read More

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http://dx.doi.org/10.1093/jtm/tay150DOI Listing
December 2018

Lymphoproliferative disease in the rectum 4 years after local mesenchymal stromal cell therapy for refractory perianal Crohn's fistulas: a case report.

J Crohns Colitis 2018 Dec 18. Epub 2018 Dec 18.

Dept. Gastroenterology and Hepatology, Leiden University Medical Center, The Netherlands.

Mesenchymal stromal cell (MSC) therapy is a new treatment for perianal fistulas in Crohn's disease. Although MSC-therapy shows a favorable safety profile, long-term safety data are limited. We detected an Epstein Barr virus (EBV) associated B cell lymphoproliferative lesion in the rectum of a patient 4 years after local administration of MSCs for his perianal fistulas. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjy220DOI Listing
December 2018

Brain Functional Organization Associated With Language Lateralization.

Cereb Cortex 2018 Dec 15. Epub 2018 Dec 15.

Key Laboratory of Brain Functional Genomics (MOE & STCSM), Shanghai Changning-ECNU Mental Health Center, Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.

Although it is well-established that human language functions are mostly lateralized to the left hemisphere of the brain, little is known about the functional mechanisms underlying such hemispheric dominance. The present study investigated intrinsic organization of the whole brain at rest, by means of functional connectivity and graph theoretical analysis, with the aim to characterize brain functional organization underlying typical and atypical language dominance. We included healthy left-handers, both those with typical left-lateralized language and those with atypical right-lateralized language. Read More

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http://dx.doi.org/10.1093/cercor/bhy313DOI Listing
December 2018

Ancient barley landraces adapted to marginal soils demonstrate exceptional tolerance to manganese limitation.

Ann Bot 2018 Dec 15. Epub 2018 Dec 15.

Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg C., Denmark.

Background And Aims: Micronutrient deficiency in cereals is a problem of global significance, severely reducing grain yield and quality in marginal soils. Ancient landraces represent, through hundreds of years of local adaptation to adverse soil conditions, a unique reservoir of genes and unexplored traits for enhancing yield and abiotic stress tolerance. Here we explored and compared the genetic variation in a population of Northern European barley landraces and modern elite varieties, and their tolerance to manganese (Mn) limitation. Read More

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http://dx.doi.org/10.1093/aob/mcy215DOI Listing
December 2018

Construction of the REACHES climate database based on historical documents of China.

Sci Data 2018 Dec 18;5:180288. Epub 2018 Dec 18.

School of Big Data Management, Soochow University, 70 Linhsi Road, Shihlin, Taipei City 111, Taiwan.

This paper describes the methodology of an ongoing project of constructing an East Asian climate database REACHES based on Chinese historical documents. The record source is Compendium of Meteorological Records of China in the Last 3000 Years which collects meteorology and climate related records from mainly official and local chronicles along with a small number of other documents. We report the digitization of the records covering the period 1644-1795. Read More

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http://dx.doi.org/10.1038/sdata.2018.288DOI Listing
December 2018

How and when investigating and treating Helicobacter pylori infection in children.

Acta Biomed 2018 Dec 17;89(8-S):65-71. Epub 2018 Dec 17.

Azienda USL of Reggio Emilia-IRCCS, Maternal and Child Department, Pediatric Unit, Sant'Anna Hospital, Castelnovo ne' Monti, Reggio Emilia, Italy.

For thousands of years humans have lived in symbiosis with Helicobacter pylori. This infection is acquired mainly during childhood and, despite it represents one of the most common infections in humans, only a minority of infected people may develop health issues and life-threatening diseases. For diagnosing Helicobacter pylori infection in children we can use, at first, non-invasive diagnostic tests, if clinical pattern and/or history are of suspicion. Read More

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December 2018

Bronchus-associated lymphoid tissue-resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection.

J Clin Invest 2018 Dec 18. Epub 2018 Dec 18.

Department of Surgery.

Antibody-mediated rejection (AMR) is a principal cause of acute and chronic failure of lung allografts. However, mechanisms mediating this oftentimes fatal complication are poorly understood. Here, we show that Foxp3+ T cells formed aggregates in rejection-free human lung grafts and accumulated within induced bronchus-associated lymphoid tissue (BALT) of tolerant mouse lungs. Read More

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http://dx.doi.org/10.1172/JCI122083DOI Listing
December 2018

TomoTherapy treatments of multiple brain lesions: an in-phantom accuracy evaluation.

Phys Med Biol 2018 Dec 18. Epub 2018 Dec 18.

Experimental and Clinical Biomedical Sciences "Mario Serio", Universita di Firenze, Largo Brambilla, 3, Florence, 50134, ITALY.

Purpose: Aim of the present study was to evaluate the accuracy which can be obtained with Helical TomoTherapy ® (HT, Accuray) systems in the case of multiple intracranial targets treatments. Materials and methods: Set-up accuracy was measured, for different registration options and MegaVoltage CT (MVCT) slice thickness, by applying known misalignments to an ad-hoc developed phantom. End-to-End (E2E) tests were performed to assess the delivery accuracy in phantoms containing multiple targets by using radiochromic films: measured dose distribution centroids were compared with physical and calculated target positions on axial and coronal planes. Read More

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http://dx.doi.org/10.1088/1361-6560/aaf977DOI Listing
December 2018

ℓ₀-Motivated Low-Rank Sparse Subspace Clustering.

IEEE Trans Cybern 2018 Dec 11. Epub 2018 Dec 11.

In many applications, high-dimensional data points can be well represented by low-dimensional subspaces. To identify the subspaces, it is important to capture a global and local structure of the data which is achieved by imposing low-rank and sparseness constraints on the data representation matrix. In low-rank sparse subspace clustering (LRSSC), nuclear and ℓ₁-norms are used to measure rank and sparsity. Read More

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http://dx.doi.org/10.1109/TCYB.2018.2883566DOI Listing
December 2018

Optimal Decentralized Output-Feedback LQG Control With Random Communication Delay.

IEEE Trans Cybern 2018 Dec 11. Epub 2018 Dec 11.

This paper is concerned with the optimal decentralized output-feedback control of the large-scale systems. A random information pattern is considered, where the information is transmitted among the subsystems with random communication delays. For the random information pattern, the optimal LQG problems for both global estimation case and local estimation case are studied. Read More

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http://dx.doi.org/10.1109/TCYB.2018.2868968DOI Listing
December 2018

Aromatic Pathways in Porphycene Derivatives Based on Current-Density Calculations.

J Phys Chem A 2018 Dec 18. Epub 2018 Dec 18.

Magnetically induced current densities have been calculated for porphycenes at the density functional theory (DFT) level of theory using gauge-including atomic orbitals to ensure gauge-origin independence and a fast basis-set convergence of the current densities. The current densities have been analyzed by using the gauge-including magnetically induced current (GIMIC) method. The porphycenes are aromatic sustaining strong diatropic ring currents. Read More

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http://dx.doi.org/10.1021/acs.jpca.8b10818DOI Listing
December 2018

Tortuosity Effects in Garnet-Type LiLaZrO Solid Electrolytes.

ACS Appl Mater Interfaces 2018 Dec 18. Epub 2018 Dec 18.

Intrinsic material properties such as pores or void spaces, grains, and defects can affect local lithium ion concentration profiles and transport properties in solid ion conductors. The formation of lithium deficient or excess regions can accelerate degradation phenomena such as dendrite formation, lithium plating, and electrode│electrolyte delamination. This paper evaluates the effects pores or void spaces have on the tortuosity of a garnet-type LiLaZrO solid electrolyte. Read More

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http://dx.doi.org/10.1021/acsami.8b16536DOI Listing
December 2018

Energy Band Gap Modulation in Nd-doped BiFeO/SrRuO Heteroepitaxial for Visible Light Photoelectrochemical Activity.

ACS Appl Mater Interfaces 2018 Dec 18. Epub 2018 Dec 18.

The ability of band offsets at multiferroic/metal and multiferroic/electrolyte interfaces in controlling charge transfer, and thus alters the photoactivity performance has sparked significant attention in solar energy conversion applications. Here, we demonstrate that the band offsets of the two interfaces play the key role in determining charge transport direction in a downward self-polarized BFO film. Electrons tend to move to BFO/electrolyte interface for water reduction. Read More

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http://dx.doi.org/10.1021/acsami.8b17758DOI Listing
December 2018

Effects of anthropogenic disturbance on primate density at the landscape scale.

Conserv Biol 2018 Dec 18. Epub 2018 Dec 18.

Tropical Biodiversity Section, MUSE - Museo delle Scienze, Corso del Lavoro e della Scienza 3, 38122, Trento, Italy.

With biodiversity facing global unparalleled loss, accurate estimations of the abundance of threatened animal populations are required to assess status and vulnerability, and provide conservation recommendations. However, density estimation is usually difficult and resource demanding, hence studies are often performed at the scale of local sites or habitat patches. Yet, anthropogenic pressures most often impact at the landscape level, for example through habitat loss and fragmentation. Read More

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http://dx.doi.org/10.1111/cobi.13269DOI Listing
December 2018

Plasma asymmetric dimethylarginine concentrations are not related to differences in maximal oxygen uptake in endurance trained and untrained men.

Exp Physiol 2018 Nov 22. Epub 2018 Nov 22.

University of Lille, University of Artois, University of Littoral Côte, d'Opale, EA 7369 - URePSSS, Pluridisciplinary Research Unit, "Sport, Health and Society", F-59000, Lille, France.

New Findings: What is the central question of this study? Is there an association of plasma concentration of asymmetric dimethylarginine, which is related to exercise capacity in patients with cardiovascular diseases, with oxygen delivery and subsequently exercise capacity in healthy subjects in the absence of the potentially confounding influence of inflammation and oxidative stress? What is the main finding and its importance? Plasma asymmetric dimethylarginine concentrations are not related to exercise capacity in healthy subjects, while O delivery in the working skeletal muscle during the maximal graded-exercise test is not associated with any of the l-arginine analogues. ADMA alone does not play a crucial role in local muscle perfusion and in maintaining exercise capacity.

Abstract: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis that could limit oxygen (O ) delivery in the working skeletal muscles by altering endothelium-dependent vasodilatation. Read More

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http://dx.doi.org/10.1113/EP087398DOI Listing
November 2018

Subclinical Hypothyroidism During Pregnancy: The Melbourne Public Hospitals Consensus.

Intern Med J 2018 Dec 18. Epub 2018 Dec 18.

Department of Endocrinology & Diabetes, Northern Health, 185 Cooper Street Epping, 3076.

Background: Interest in potential adverse outcomes associated with maternal subclinical hypothyroidism (normal Free T4, elevated TSH) has increased significantly over recent years. In turn, the frequency of maternal thyroid function testing has risen, despite universal thyroid function screening not being recommended, leading to a marked increase in referrals to obstetric endocrinology clinics. In 2017 the American Thyroid Association (ATA) revised their diagnostic and management guidelines. Read More

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http://dx.doi.org/10.1111/imj.14210DOI Listing
December 2018

Recrystallisation behaviour of a fully austenitic Nb-stabilised stainless steel.

J Microsc 2018 Dec 17. Epub 2018 Dec 17.

Materials Performance Centre, School of Materials, The University of Manchester, Manchester, UK.

We have performed an in-depth characterisation of the microstructure evolution of 20Cr-25Ni Nb-stabilised austenitic stainless steel during 1 h isochronal annealing up to 1100°C using scanning electron microscopy. This steel grade is used as cladding material in Advanced Gas-cooled fission reactors, due to its resistance to thermal creep and oxidation. The initial deformed microstructure undergoes recrystallisation via a strain-induced boundary migration mechanism, attaining a fully recrystallised microstructure at 850°C. Read More

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http://dx.doi.org/10.1111/jmi.12776DOI Listing
December 2018

Percutaneous ethanol ablation of intrahepatic arterial pseudoaneurysm: A case report.

J Clin Ultrasound 2018 Dec 18. Epub 2018 Dec 18.

Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.

Hepatic arterial pseudoaneurysm is a rare but potentially fatal condition that requires prompt management. We report a case of hepatic arterial pseudoaneurysm developed after radiofrequency ablation of a hepatocellular carcinoma. The patient was successfully treated with percutaneous absolute ethanol injection under ultrasound guidance. Read More

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http://dx.doi.org/10.1002/jcu.22678DOI Listing
December 2018

Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep.

Nat Commun 2018 Dec 18;9(1):5364. Epub 2018 Dec 18.

Sorbonne Université, CNRS, INSERM, Institut de Biologie Paris Seine-Neuroscience, 9 quai Saint-Bernard, 75005, Paris, France.

Rapid eye movement sleep (REMS) is a peculiar brain state combining the behavioral components of sleep and the electrophysiological profiles of wake. After decades of research our understanding of REMS still is precluded by the difficulty to observe its spontaneous dynamics and the lack of multimodal recording approaches to build comprehensive datasets. We used functional ultrasound (fUS) imaging concurrently with extracellular recordings of local field potentials (LFP) to reveal brain-wide spatiotemporal hemodynamics of single REMS episodes. Read More

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http://dx.doi.org/10.1038/s41467-018-07752-3DOI Listing
December 2018

PhoglyStruct: Prediction of phosphoglycerylated lysine residues using structural properties of amino acids.

Sci Rep 2018 Dec 18;8(1):17923. Epub 2018 Dec 18.

Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan.

The biological process known as post-translational modification (PTM) contributes to diversifying the proteome hence affecting many aspects of normal cell biology and pathogenesis. There have been many recently reported PTMs, but lysine phosphoglycerylation has emerged as the most recent subject of interest. Despite a large number of proteins being sequenced, the experimental method for detection of phosphoglycerylated residues remains an expensive, time-consuming and inefficient endeavor in the post-genomic era. Read More

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http://dx.doi.org/10.1038/s41598-018-36203-8DOI Listing
December 2018

YKL-40 is a local marker for inflammation in patients with pseudoexfoliation syndrome.

Eye (Lond) 2018 Dec 18. Epub 2018 Dec 18.

Bahcesehir University, School of Medicine, Department of Medical Ethics and History of Medicine, Istanbul, Turkey.

Purpose: To investigate the YKL-40, as a marker of inflammation, in aqueous humor and serum of cataract patients with and without pseudoexfoliation syndrome (PEX).

Methods: Aqueous humor and serum samples were obtained from 44 patients who underwent phacoemulsification surgery. All patients were divided into two groups: PEX (n = 24) and control (n = 20). Read More

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http://dx.doi.org/10.1038/s41433-018-0308-8DOI Listing
December 2018

Fast oxygen dynamics as a potential biomarker for epilepsy.

Sci Rep 2018 Dec 18;8(1):17935. Epub 2018 Dec 18.

Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.

Changes in brain activity can entrain cerebrovascular dynamics, though this has not been extensively investigated in pathophysiology. We assessed whether pathological network activation (i.e. Read More

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http://dx.doi.org/10.1038/s41598-018-36287-2DOI Listing
December 2018
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